CN109187942A - A kind of Test paper and preparation method thereof - Google Patents
A kind of Test paper and preparation method thereof Download PDFInfo
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- CN109187942A CN109187942A CN201810876084.3A CN201810876084A CN109187942A CN 109187942 A CN109187942 A CN 109187942A CN 201810876084 A CN201810876084 A CN 201810876084A CN 109187942 A CN109187942 A CN 109187942A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
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Abstract
The present invention discloses a kind of Test paper and preparation method thereof, and Test paper includes bottom plate, the first articulamentum, blotting paper, test-strips, the second articulamentum, top plate and cover film;First articulamentum is between blotting paper and bottom plate, blotting paper includes the first side, the second side and the middle part between the first side and the second side, second articulamentum is between top plate and the second side, middle part is equipped with test-strips, test-strips are close to top plate, cover film is covered and is sticked in the first side, test-strips and top plate, the production method of Test paper includes sticking blotting paper on the first articulamentum, top plate is affixed on blotting paper and is close to the test-strips of top plate, then is cut into required width after covering cover film.The present invention can accelerate the detection of test paper, false positive can also occur and the uneven situation that develops the color to avoid testing when negative sample.
Description
Technical field
The present invention relates to vitro diagnostic techniques fields more particularly to a kind of Test paper and preparation method thereof.
Background technique
Test paper, refer to chemicals it is impregnated, can be deposited by Cucumber in its color change detecting liquid or gas
A kind of paper.
Test paper is fabricated to after test strips by certain step and is put into test fluid and can more safely and accurately examine
It surveys, such as detection blood, urine, saliva.
The production method of existing test strips is all one piece of substrate of selection mostly, the barrier paper on substrate is torn off, first in base
Blotting paper is pasted in the upper half of plate, then sticks the test paper that one end partially overlaps with blotting paper, finally sticks another with blotting paper
The blotting paper that end part is overlapped, is finally cut into the test strips for needing width.But test strips made from such method are tested
When, due to the method using chromatography, on the one hand when testing negative sample, it is easy to produce false positive, color when on the other hand testing
Block is easy up to run, and causes colour developing uneven.
Summary of the invention
It is an object of the present invention to be directed to the above-mentioned deficiency of the prior art, a kind of Test paper and preparation method thereof is proposed.
The present invention solves its technical problem, the technical solution adopted is that, it proposes a kind of novel ethyl alcohol Test paper, wraps
It includes: bottom plate, the first articulamentum, blotting paper, test-strips, the second articulamentum, top plate and cover film;First articulamentum
Between the blotting paper and bottom plate, the blotting paper is including the first side, the second side and is located at first side
With the middle part between the second side, second articulamentum is between the top plate and the second side, the middle part
Test-strips are equipped with, the test-strips are close to the top plate, and the cover film is covered and sticked in first side, test-strips
And top plate.
Preferably, the bottom plate and the length of top plate ratio are 2~2.5:1.
Preferably, the length of the test-strips is 0.5~1.5cm.
Preferably, the top plate has the extension being covered on above the test-strips, the test-strips and extension
The length ratio in portion is 3~5:1.The thickness of extension is smaller than top plate, and there are certain spaces for filling in test-strips, extends simultaneously
Portion has certain flexibility, and test-strips can be tightly fixed when cover film is covered, can be become to avoid test-strips position
Change, this ratio further aspect conveniently fills in test-strips, on the other hand avoids large area coverage test item and cause extension to survey
Strip different parts have different pressure and cause to permeate when follow-up test uneven.
Preferably, first articulamentum and the second articulamentum are waterproof double-sided adhesive, and the first articulamentum and second connects
Connect the glass microballoon that gathers inside layer.Non-water-tight double-sided adhesive can absorb sample, thus need to increase sample size, while may
Lead to the inaccuracy of result;Gather glass microballoon inside first articulamentum and the second articulamentum, on the one hand since glass microballoon does not have
There is stress high concentration phenomenon, can be to avoid the fracture phenomena of the glue surface when squeezing, and can keep stablizing in subsequent use,
The intensity of the first articulamentum and the second articulamentum can be improved in other hand, is not likely to produce deformation, and because of shape when avoiding squeezing
Become and generate discontinuity equalization generate follow-up test result inaccuracy.
Another object of the present invention is to propose a kind of production method of novel ethyl alcohol Test paper, include the following steps:
A), the bottom plate being connected with first articulamentum is taken, the diaphragm being covered on first articulamentum is torn off,
The blotting paper is sticked on first articulamentum;
B), the top plate being connected with second articulamentum is taken, the diaphragm being covered on second articulamentum is torn off,
By being connected with second side for second articulamentum, the test-strips are placed on middle part, and the test-strips are close to
Top plate;
C), the cover film is covered and is sticked on first side, test-strips and top plate, obtain test strips;
D), test strips are cut into required width with cutter machine.
Preferably, the both ends that the test-strips are parallel to blotting paper water suction direction are equipped with connection in step b)
The glutinous item of the test-strips and blotting paper.The position of preferably fixed blotting paper, prevents that position occurs when covering cover film
Variation.
Preferably, the width of the glutinous item is less than or equal to width needed for step d).Cutter machine-cut subsequent in this way
When test strips, remove the both ends containing glutinous item with regard to very convenient.
Preferably, the cover film is covered and is sticked in first side, test-strips and top plate in step c)
It is trimmed after upper.
Preferably, further including sticker in step a), the sticker includes for placing the bottom plate
Pedestal and roll shaft, the roll shaft be equipped with around paper portion, the pedestal include for the roll shaft roll the first groove and setting exist
The first groove lower section and the second groove for accommodating the bottom plate, the pedestal have the protrusion around first groove
Ring, the protruding ring are equipped with limit sliding chutes on the direction that roll shaft rolls, and the roll shaft is equipped with corresponding with the limit sliding chutes
Limited roller.Can to paste it is more smooth, uniform, will not pasting because of blotting paper so that subsequent when testing
Problem causes test result inaccurate, while this set equipment is suitable for step c), and existing promotion machine can be used to push roller
Axis, the stabilization of pressure when can guarantee to paste in this way.
Preferably, being greater than or equal to the depth of the first groove around the radius in paper portion.It can not be finished just to avoid blotting paper
The case where can not pasting.
Preferably, the bottom of the limit sliding chutes is equipped with magnet.In limited roller there is iron block etc. can produce with magnet
The substance of raw suction when producing different test strips in this way, pastes suction since meeting of use of blotting paper is so that entirely roll shaft lightens
Will appear when water paper causes follow-up test to have a certain difference because of pressure difference, can move down, be arranged while roll shaft lightens
Magnet generates stronger suction while can to move down, so that pressure can be reached by having no need to change the power acted on roll shaft
Power is balanced.
By implementing above-mentioned technical proposal, the present invention has the advantage that: the present invention is by the way that test-strips are directly arranged
On blotting paper and upper cover film is covered, on the one hand can accelerate the detection of test paper, on the other hand avoids testing negative sample
Occur false positive and colour developing uneven situation when product, due on the Liquid Penetrant to test-strips on blotting paper, rather than uses layer
The method of analysis thus is avoided that color lump up runs and causes the liquid distribution in test-strips uneven, to avoid because of color lump unevenness
The false positive of even generation and colour developing are uneven.
Detailed description of the invention
Fig. 1 is the side view of test-strips in the embodiment of the present invention 1 and embodiment 3;
Fig. 2 is the top view of blotting paper in the present invention;
Fig. 3 is the side view in the embodiment of the present invention 2 with 4 test-strips of embodiment;
Fig. 4 is the cross-sectional view of sticking device in embodiment 3;
Fig. 5 is the top view of pedestal in embodiment 3 and embodiment 4;
Fig. 6 is the cross-sectional view of sticking device in embodiment 4.
In figure, 1, bottom plate, 2, blotting paper, 3, test-strips, 4, top plate, 5, cover film, the 6, first articulamentum, 7, second
Articulamentum, the 21, first side, the 22, second side, 23, middle part, 41, extension, 8, sticking device, 81, pedestal, 82, roller
Axis, 821, around paper portion, the 811, first groove, the 812, second groove, 813, protruding ring, 8131, limit sliding chutes, 822, limit rolling
Wheel, 9, magnet.
Specific embodiment
Following is a specific embodiment of the present invention in conjunction with the accompanying drawings, technical scheme of the present invention will be further described,
However, the present invention is not limited to these examples.
Embodiment 1:
A kind of Test paper as shown in Fig. 1 to 2, including bottom plate 1, the first articulamentum 6, blotting paper 2, test-strips 3, second connect
Connect layer 7, top plate 4 and cover film 5.Test-strips select various test strips on the market.
For first articulamentum 6 between blotting paper 2 and bottom plate 1, blotting paper 2 includes the first side 21, the second side 22
And the middle part 23 between the first side 21 and the second side 22, the second articulamentum are located at top plate 4 and the second side 21
Between, middle part 23 is equipped with test-strips 3, and test-strips 3 are close to top plate 4, and cover film 5 covers and sticks in the first side 22, surveys
Strip 3 and top plate 4.By the way that test-strips to be set up directly on blotting paper to and covered cover film, on the one hand can accelerate to survey
On the other hand the detection of test paper avoids the situation for occurring false positive and colour developing unevenness when testing negative sample, due to blotting paper
On Liquid Penetrant to test-strips on, rather than use chromatography method, thus be avoided that color lump up runs and causes in test-strips
Liquid distribution it is uneven, to avoid the false positive unevenly generated by color lump and colour developing uneven.
The length ratio of bottom plate 1 and top plate 4 is 2~2.5:1.The length ratio that the present embodiment selects is 2:1
The length of test-strips 3 is 0.5~1.5cm.The length that the present embodiment selects is 1cm.
A kind of production method of Test paper, includes the following steps:
A, the bottom plate being connected with the first articulamentum 6 is taken, the diaphragm being covered on the first articulamentum is torn off, blotting paper 3 is sticked
On the first articulamentum 6;
B, the top plate 4 being connected with the second articulamentum 7 is taken, the diaphragm being covered on the second articulamentum 7 is torn off, by the second connection
Layer 7 is connected with the second side 22, and test-strips 3 are placed on middle part 23, and test-strips 3 are close to top plate 4;
C, cover film 5 is covered and is sticked on the first side 21, test-strips 3 and top plate 4, obtain test strips;
D, test strips are cut into required width with cutter machine.
Embodiment 2:
A kind of Test paper as shown in Fig. 2 to 3, including bottom plate 1, the first articulamentum 6, blotting paper 2, test-strips 3, second connect
Connect layer 7, top plate 4 and cover film 5.Test-strips select various test strips on the market.
For first articulamentum 6 between blotting paper 2 and bottom plate 1, blotting paper 2 includes the first side 21, the second side 22
And the middle part 23 between the first side 21 and the second side 22, the second articulamentum are located at top plate 4 and the second side 21
Between, middle part 23 is equipped with test-strips 3, and test-strips 3 are close to top plate 4, and cover film 5 covers and sticks in the first side 22, surveys
Strip 3 and top plate 4.
The length ratio of bottom plate 1 and top plate 4 is 2~2.5:1.The length ratio that the present embodiment selects is 2.5:1
The length of test-strips 3 is 0.5~1.5cm.The length that the present embodiment selects is 0.5cm.
Top plate 4 has an extension 41 for being covered on the top of test-strips 3, and the length ratio of test-strips 3 and extension 41 is 3~
5:1.The length ratio that the present embodiment selects is 3:1, and the thickness of extension is smaller than top plate, and there are certain spaces for filling in test
Item, while extension has certain flexibility, and test-strips can be tightly fixed when cover film is covered, it can be to avoid survey
Strip change in location, this ratio further aspect conveniently fill in test-strips, on the other hand avoid large area coverage test item and cause
Extension has different pressure to test-strips different parts and causes to permeate when follow-up test uneven.
First articulamentum and the second articulamentum are waterproof double-sided adhesive, and the glass that gathers inside the first articulamentum and the second articulamentum
Glass microballon.Non-water-tight double-sided adhesive can absorb sample, thus need to increase sample size, while may result in the inaccurate of result
Really;Gather glass microballoon inside first articulamentum and the second articulamentum, on the one hand since glass microballoon does not have stress high concentration
Phenomenon, can be to avoid the fracture phenomena of the glue surface when squeezing, and can keep stablizing in subsequent use, and other hand can mention
The intensity of high first articulamentum and the second articulamentum, is not likely to produce deformation, and avoids the stress generated when squeezing because of deformation
The unbalanced inaccuracy for generating follow-up test result.
A kind of production method of Test paper, includes the following steps:
A, the bottom plate being connected with the first articulamentum 6 is taken, the diaphragm being covered on the first articulamentum is torn off, blotting paper 3 is sticked
On the first articulamentum 6;
B, the top plate 4 being connected with the second articulamentum 7 is taken, the diaphragm being covered on the second articulamentum 7 is torn off, by the second connection
Layer 7 is connected with the second side 22, and test-strips 3 are placed on middle part 23, and test-strips 3 are close to top plate 4;In this embodiment,
Extension is filled in into the part of test-strips.
C, cover film 5 is covered and is sticked on the first side 21, test-strips 3 and top plate 4, obtain test strips;
D, test strips are cut into required width with cutter machine.
In stepb, the both ends that test-strips 3 are parallel to the water suction of blotting paper 2 direction are equipped with connecting test item 3 and blotting paper 2
Glutinous item.The position of preferably fixed blotting paper prevents the variation that position occurs when covering cover film.Glutinous item also uses waterproof
Double-sided adhesive.
The width of glutinous item is less than or equal to width needed for step d.So subsequent cutter machine-cut test strips when, remove and contain
There are the both ends of glutinous item with regard to very convenient.
In step c, cover film 5 is covered and is trimmed after sticking on the first side 21, test-strips 3 and top plate 4.
Embodiment 3:
A kind of Test paper as shown in Fig. 1,2,4,5, including bottom plate 1, the first articulamentum 6, blotting paper 2, test-strips 3,
Two articulamentums 7, top plate 4 and cover film 5.Test-strips select various test strips on the market.
For first articulamentum 6 between blotting paper 2 and bottom plate 1, blotting paper 2 includes the first side 21, the second side 22
And the middle part 23 between the first side 21 and the second side 22, the second articulamentum are located at top plate 4 and the second side 21
Between, middle part 23 is equipped with test-strips 3, and test-strips 3 are close to top plate 4, and cover film 5 covers and sticks in the first side 22, surveys
Strip 3 and top plate 4.
The length ratio of bottom plate 1 and top plate 4 is 2~2.5:1.The length ratio that the present embodiment selects is 2.25:1
The length of test-strips 3 is 0.5~1.5cm.The length that the present embodiment selects is 1.5cm.
First articulamentum and the second articulamentum are waterproof double-sided adhesive, and the glass that gathers inside the first articulamentum and the second articulamentum
Glass microballon.
A kind of production method of Test paper, includes the following steps:
A, the bottom plate being connected with the first articulamentum 6 is taken, the diaphragm being covered on the first articulamentum is torn off, blotting paper 3 is sticked
On the first articulamentum 6;
B, the top plate 4 being connected with the second articulamentum 7 is taken, the diaphragm being covered on the second articulamentum 7 is torn off, by the second connection
Layer 7 is connected with the second side 22, and test-strips 3 are placed on middle part 23, and test-strips 3 are close to top plate 4;
C, cover film 5 is covered and is sticked on the first side 21, test-strips 3 and top plate 4, obtain test strips;
D, test strips are cut into required width with cutter machine.
In stepb, the both ends that test-strips 3 are parallel to the water suction of blotting paper 2 direction are equipped with connecting test item 3 and blotting paper 2
Glutinous item.The position of preferably fixed blotting paper prevents the variation that position occurs when covering cover film.
The width of glutinous item is less than or equal to width needed for step d.So subsequent cutter machine-cut test strips when, remove and contain
There are the both ends of glutinous item with regard to very convenient.
In step c, cover film 5 is covered and is trimmed after sticking on the first side 21, test-strips 3 and top plate 4.
It further include sticker 8 in step a, sticker 8 includes the pedestal 81 and roll shaft for placing bottom plate 1
82, roll shaft 82 is equipped with around paper portion 821, and pedestal 81 includes the first groove 811 rolled for roll shaft 82 and is arranged in the first groove 811
Lower section and the second groove 812 for accommodating bottom plate 1, pedestal 81 have the protruding ring 813 around the first groove 811, protruding ring 813
Limit sliding chutes 8131 are equipped on the direction that roll shaft 82 rolls, roll shaft 82 is equipped with limited roller corresponding with limit sliding chutes 8131
822.It can to paste more smooth, uniform, so that subsequent when testing, will not cause because of the problem of pasting of blotting paper
Test result is inaccurate, while this set equipment is suitable for step c, and existing promotion machine can be used to push roll shaft, in this way may be used
The stabilization of pressure when guaranteeing to paste.
It is greater than or equal to the depth of the first groove around the radius in paper portion.Can not be finished to avoid blotting paper can not just paste
Situation.
Embodiment 4:
A kind of Test paper as shown in Fig. 2,3,5,6, including bottom plate 1, the first articulamentum 6, blotting paper 2, test-strips 3,
Two articulamentums 7, top plate 4 and cover film 5.Test-strips select various test strips on the market.
For first articulamentum 6 between blotting paper 2 and bottom plate 1, blotting paper 2 includes the first side 21, the second side 22
And the middle part 23 between the first side 21 and the second side 22, the second articulamentum are located at top plate 4 and the second side 21
Between, middle part 23 is equipped with test-strips 3, and test-strips 3 are close to top plate 4, and cover film 5 covers and sticks in the first side 22, surveys
Strip 3 and top plate 4.
The length ratio of bottom plate 1 and top plate 4 is 2~2.5:1.The length ratio that the present embodiment selects is 2.25:1
The length of test-strips 3 is 0.5~1.5cm.The length that the present embodiment selects is 1.5cm.
Top plate 4 has an extension 41 for being covered on the top of test-strips 3, and the length ratio of test-strips 3 and extension 41 is 3~
5:1.The length ratio of the present embodiment is 4:1.
First articulamentum and the second articulamentum are waterproof double-sided adhesive, and the glass that gathers inside the first articulamentum and the second articulamentum
Glass microballon.
A kind of production method of Test paper, includes the following steps:
A, the bottom plate being connected with the first articulamentum 6 is taken, the diaphragm being covered on the first articulamentum is torn off, blotting paper 3 is sticked
On the first articulamentum 6;
B, the top plate 4 being connected with the second articulamentum 7 is taken, the diaphragm being covered on the second articulamentum 7 is torn off, by the second connection
Layer 7 is connected with the second side 22, and test-strips 3 are placed on middle part 23, and test-strips 3 are close to top plate 4;In this embodiment,
Extension is filled in into the part of test-strips.
C, cover film 5 is covered and is sticked on the first side 21, test-strips 3 and top plate 4, obtain test strips;
D, test strips are cut into required width with cutter machine.
In stepb, the both ends that test-strips 3 are parallel to the water suction of blotting paper 2 direction are equipped with connecting test item 3 and blotting paper 2
Glutinous item.
The width of glutinous item is less than or equal to width needed for step d.
In step c, cover film 5 is covered and is trimmed after sticking on the first side 21, test-strips 3 and top plate 4.
It further include sticker 8 in step a, sticker 8 includes the pedestal 81 and roll shaft for placing bottom plate 1
82, roll shaft 82 is equipped with around paper portion 821, and pedestal 81 includes the first groove 811 rolled for roll shaft 82 and is arranged in the first groove 811
Lower section and the second groove 812 for accommodating bottom plate 1, pedestal 81 have the protruding ring 813 around the first groove 811, protruding ring 813
Limit sliding chutes 8131 are equipped on the direction that roll shaft 82 rolls, roll shaft 82 is equipped with limited roller corresponding with limit sliding chutes 8131
822。
It is greater than or equal to the depth of the first groove around the radius in paper portion.
The bottom of limit sliding chutes 8131 is equipped with magnet 9.In limited roller suction can be generated with magnet with iron block etc.
Substance, since the meeting of use of blotting paper is so that entire roll shaft lightens, when producing different test strips in this way, meeting when pasting blotting paper
Occur causing follow-up test to have a certain difference because of pressure difference, can be moved down while roll shaft lightens, setting magnet can be with
So that stronger suction is generated while moving down, so that pressure equilibrium can be reached by having no need to change the power acted on roll shaft.
Specific embodiment described herein is only an example for the spirit of the invention.The neck of technology belonging to the present invention
The technical staff in domain can make various modifications or additions to the described embodiments or replace by a similar method
In generation, however, it does not deviate from the spirit of the invention or beyond the scope of the appended claims.
Claims (10)
1. a kind of Test paper characterized by comprising bottom plate (1), the first articulamentum (6), blotting paper (2), test-strips
(3), the second articulamentum (7), top plate (4) and cover film (5);First articulamentum (6) be located at the blotting paper (2) and
Between bottom plate (1), the blotting paper (2) includes the first side (21), the second side (22) and is located at first side
(21) middle part (23) between the second side (22), second articulamentum are located at the top plate (4) and the second side
(21) between, the middle part (23) is equipped with test-strips (3), and the test-strips (3) are close to the top plate (4), described to cover
Epiphragma (5) is covered and is sticked in first side (22), test-strips (3) and top plate (4).
2. a kind of Test paper according to claim 1, it is characterised in that: the length of the bottom plate (1) and top plate (4)
Degree is than being 2~2.5:1.
3. a kind of Test paper according to claim 1, it is characterised in that: the length of the test-strips (3) be 0.5~
1.5cm。
4. a kind of Test paper according to claim 1 or 3, it is characterised in that: the top plate (4), which has, is covered on institute
State the extension (41) above test-strips (3), the length ratio of the test-strips (3) and extension (41) is 3~5:1.
5. a kind of production method of Test paper, which comprises the steps of:
A), the bottom plate being connected with first articulamentum (6) is taken, the diaphragm being covered on first articulamentum is torn
It goes, the blotting paper (3) is sticked on first articulamentum (6);
B), the top plate (4) being connected with second articulamentum (7) is taken, will be covered on second articulamentum (7)
Diaphragm is torn off, and by being connected with second side (22) for second articulamentum (7), the test-strips (3) are placed on centre
In portion (23), the test-strips (3) are close to top plate (4);
C), the cover film (5) are covered and is sticked on first side (21), test-strips (3) and top plate (4), obtained
Test strips;
D), test strips are cut into required width with cutter machine.
6. a kind of production method of Test paper according to claim 5, it is characterised in that: in step b), the survey
The both ends that strip (3) is parallel to the blotting paper (2) water suction direction, which are equipped with, connects sticking for the test-strips (3) and blotting paper (2)
Item.
7. a kind of production method of Test paper according to claim 6, it is characterised in that: the width of the glutinous item is less than
Or it is equal to width needed for step d).
8. a kind of production method of Test paper according to claim 5, it is characterised in that:, will be described in step c)
Cover film (5) is covered and is trimmed after sticking on first side (21), test-strips (3) and top plate (4).
9. a kind of production method of Test paper according to claim 5, it is characterised in that: in step a), further include
Sticker (8), the sticker (8) include for placing the pedestal of the bottom plate (1) (81) and roll shaft (82), it is described
Roll shaft (82) is equipped with around paper portion (821), and the pedestal (81) includes the first groove (811) rolled for the roll shaft (82) and sets
The second groove (812) of the bottom plate (1) is set below first groove (811) and accommodates, the pedestal (81) has
Around the protruding ring (813) of first groove (811), the protruding ring (813) is equipped on the direction that roll shaft (82) rolls
Limit sliding chutes (8131), the roll shaft (82) are equipped with limited roller (822) corresponding with the limit sliding chutes (8131).
10. a kind of production method of Test paper according to claim 9, it is characterised in that: the limit sliding chutes
(8131) bottom is equipped with magnet (9).
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CN201810876084.3A CN109187942B (en) | 2018-08-03 | 2018-08-03 | Detection test paper and manufacturing method thereof |
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