CN109172749A - 一种治疗痛风的药酒及其制备方法 - Google Patents

一种治疗痛风的药酒及其制备方法 Download PDF

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CN109172749A
CN109172749A CN201811146987.2A CN201811146987A CN109172749A CN 109172749 A CN109172749 A CN 109172749A CN 201811146987 A CN201811146987 A CN 201811146987A CN 109172749 A CN109172749 A CN 109172749A
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liquid medicine
treatment
gout
filtrate
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温锦书
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Abstract

本发明公开了一种治疗痛风的药酒，包括如下组分：党参、海龙、梅花鹿筋、海星、海螺、川芎、骨碎补、陈皮丝、小木瓜、五加皮、锁阳、红花、白芍、金樱子、天麻、巴吉、枸杞、一口钟、红枣、槟榔、穿破石、还魂草、茯苓、黄芪、栀子、鸡血藤、田七、穿山龙、威灵仙和黄连。本发明还提供一种治疗痛风的药酒的制备方法。本发明的药酒能够用于预防和治疗痛风，疗效显著，能够有效避免复发，且毒副作用小。

Description

一种治疗痛风的药酒及其制备方法
技术领域
本发明涉及一种药酒，尤其涉及一种治疗痛风的药酒及其制备方法。
背景技术
痛风是长期的嘌呤代谢紊乱或尿酸排泄减少所导致的血中尿酸增高引起的一组疾病，临床以高尿酸血症，特征性急性关节炎反复发作，痛风石沉积，痛风石性慢性关节炎和关节畸形，部分患者后期可累及肾脏引起的慢性间质性肾炎和尿酸性肾结石形成为主要特征，目前治疗痛风的西药以应用抗炎、抑制尿酸合成、促进尿酸排泄等药物为主，但其耐受性差且副作用较大，而对于中药古方，药效慢、疗程长，增加了患者的绝望和痛苦。
发明内容
为了克服现有技术的不足，本发明的目的之一在于提供一种治疗痛风的药酒，该药酒能够用于预防和治疗痛风，疗效显著，能够有效避免复发，且毒副作用小。
本发明的第二个目的是为了提供一种治疗痛风的药酒的制备方法，该制备方法突破了常规技术中药材的药效成分大部分无法释放的缺陷，将动物原料和植物原料分别进行处理，使得各自的药效得以充分发挥。
本发明的目的之一采用如下技术方案实现：
一种治疗痛风的药酒，包括如下组分：
党参、海龙、梅花鹿筋、海星、海螺、川芎、骨碎补、陈皮丝、小木瓜、五加皮、锁阳、红花、白芍、金樱子、天麻、巴吉、枸杞、一口钟、红枣、槟榔、穿破石、还魂草、茯苓、黄芪、栀子、鸡血藤、田七、穿山龙、威灵仙和黄连。
进一步地，以重量份计，各组分的配比如下：党参15-20份，海龙5-8份，梅花鹿筋50-80份，海星15-20份，海螺5-8份，川芎30-40份，骨碎补50-60份，陈皮丝50-60份，小木瓜100-150份，五加皮80-100份，锁阳20-30份，红花60-70份，白芍40-60份，金樱子45-50份，天麻100-120份，巴吉20-30份，枸杞50-60份，一口钟20-30份，红枣40-50份，槟榔10-15份，穿破石100-150份，还魂草30-40份，茯苓50-60份，黄芪45-60份，栀子30-40份，鸡血藤80-90份，田七100-120份，穿山龙200-250份，威灵仙100-120份，黄连50-60份。
实现本发明的第二个目的可以通过采取如下技术方案达到：
一种治疗痛风的药酒的制备方法，包括，
预处理步骤：取海龙、梅花鹿筋、海星和海螺洗净后冷冻贮藏，取出绞碎、干燥，然后微波膨化处理，得到药材粉末，将药材粉末加入碱性溶液后过滤，得到一次滤液，然后向一次滤液中进入蛋白酶溶液，酶解后灭活蛋白酶，过滤，得到二次滤液，向二次滤液中加入乙醇静置，过滤取上清液，得到第一滤液；
破壁步骤：将党参、川芎、骨碎补、陈皮丝、小木瓜、五加皮、锁阳、红花、白芍、金樱子、天麻、巴吉、枸杞、一口钟、红枣、槟榔、穿破石、还魂草、茯苓、黄芪、栀子、鸡血藤、田七、穿山龙、威灵仙和黄连以喷雾湿润，放入破壁机中，加压、升温，维持温度不变，然后瞬间减压，干燥后得到破壁药材；
浸泡步骤：将破壁药材放入热水中浸泡后，过滤去渣，得到第二滤液；
混合步骤：将一次滤液和二次滤液混合，浓缩、静置、过滤，得到治疗痛风的药酒。
进一步地，预处理步骤中，微波膨化处理的压强为0.5-1.0MPa，时间为4-6min。
进一步地，预处理步骤中，碱性溶液的pH为11-12，药材粉末与碱性溶液的重量体积比为1g：(2.2-3.0)mL。
进一步地，预处理步骤中，蛋白酶溶液与一次滤液的体积比为1：(3-4.5)；乙醇与二次滤液的体积比为1：(5-6)。
进一步地，破壁步骤中，加压至1.2-3MPa，升温至80-90℃。
进一步地，破壁步骤中，维持温度不变5-10s，减压至常压。
进一步地，浸泡步骤中，热水的温度为150-200℃，浸泡1-1.5h。
进一步地，混合步骤中，浓缩至原体积的1/6-1/4。
本发明的有益效果在于：
1、本发明治疗痛风的药酒，该药酒能够用于预防和治疗痛风，疗效显著，能够有效避免复发，且毒副作用小，并且服用方便，品质纯正，具有清热解毒、祛风除湿、活血通经的功效；
2、本发明治疗痛风的药酒的制备方法，该制备方法突破了常规技术中药材的药效成分大部分无法释放的缺陷，将动物原料和植物原料分别进行处理，使得各自的药效得以充分发挥，对于痛风具有良好的疗效。
具体实施方式
下面，结合具体实施方式，对本发明做进一步描述，需要说明的是，在不相冲突的前提下，以下描述的各实施例之间或各技术特征之间可以任意组合形成新的实施例。
一种治疗痛风的药酒，包括如下组分：
党参、海龙、梅花鹿筋、海星、海螺、川芎、骨碎补、陈皮丝、小木瓜、五加皮、锁阳、红花、白芍、金樱子、天麻、巴吉、枸杞、一口钟、红枣、槟榔、穿破石、还魂草、茯苓、黄芪、栀子、鸡血藤、田七、穿山龙、威灵仙和黄连。
作为进一步地实施方式，以重量份计，各组分的配比如下：党参15-20份，海龙5-8份，梅花鹿筋50-80份，海星15-20份，海螺5-8份，川芎30-40份，骨碎补50-60份，陈皮丝50-60份，小木瓜100-150份，五加皮80-100份，锁阳20-30份，红花60-70份，白芍40-60份，金樱子45-50份，天麻100-120份，巴吉20-30份，枸杞50-60份，一口钟20-30份，红枣40-50份，槟榔10-15份，穿破石100-150份，还魂草30-40份，茯苓50-60份，黄芪45-60份，栀子30-40份，鸡血藤80-90份，田七100-120份，穿山龙200-250份，威灵仙100-120份，黄连50-60份。
一种治疗痛风的药酒的制备方法，包括，
预处理步骤：取海龙、梅花鹿筋、海星和海螺洗净后冷冻贮藏，取出绞碎、干燥，然后微波膨化处理，得到药材粉末，将药材粉末加入碱性溶液后过滤，得到一次滤液，然后向一次滤液中进入蛋白酶溶液，酶解后灭活蛋白酶，过滤，得到二次滤液，向二次滤液中加入乙醇静置，过滤取上清液，得到第一滤液；
破壁步骤：将党参、川芎、骨碎补、陈皮丝、小木瓜、五加皮、锁阳、红花、白芍、金樱子、天麻、巴吉、枸杞、一口钟、红枣、槟榔、穿破石、还魂草、茯苓、黄芪、栀子、鸡血藤、田七、穿山龙、威灵仙和黄连以喷雾湿润，放入破壁机中，加压、升温，维持温度不变，然后瞬间减压，干燥后得到破壁药材；
浸泡步骤：将破壁药材放入热水中浸泡后，过滤去渣，得到第二滤液；
混合步骤：将一次滤液和二次滤液混合，浓缩、静置、过滤，得到治疗痛风的药酒。
作为进一步地实施方式，预处理步骤中，微波膨化处理的压强为0.5-1.0MPa，时间为4-6min。
作为进一步地实施方式，预处理步骤中，碱性溶液的pH为11-12，药材粉末与碱性溶液的重量体积比为1g：(2.2-3.0)mL。
作为进一步地实施方式，预处理步骤中，蛋白酶溶液与一次滤液的体积比为1：(3-4.5)；乙醇与二次滤液的体积比为1：(5-6)。
作为进一步地实施方式，破壁步骤中，加压至1.2-3MPa，升温至80-90℃。
作为进一步地实施方式，破壁步骤中，维持温度不变5-10s，减压至常压。
作为进一步地实施方式，浸泡步骤中，热水的温度为150-200℃，浸泡1-1.5h。
作为进一步地实施方式，混合步骤中，浓缩至原体积的1/6-1/4。
对动物原料进行处理，根据动物药材的物性和功效成分的特点，在现有工艺的基础上，将处理过程细化，不仅提高了提取效率，而且处理过程中有效成分的破坏幅度明显减小，对活性成分进行了有效的保护。
对植物原料进行破壁处理，原理是通过压力的变化使细胞内水分急速沸腾并汽化以致使植物细胞内部压力迅速升高，植物细胞壁因无法承受如此巨大压力变化而破碎，该方法为植物细胞破壁率高、破壁完全，并且不改变药材的物理形状，并且避免了传统工艺长时间煎煮的效果，节省了能耗和时间。
以下是本发明具体的实施例，在下述实施例中所采用的原材料、设备等除特殊限定外均可以通过购买方式获得。
实施例1-5：
以重量份计，实施例1-5的组分和配比如下表所示。
表1 实施例1-5的组分和配比
实施例1-5的治疗痛风的药酒的制备方法均按下列步骤进行，包括，
预处理步骤：取海龙、梅花鹿筋、海星和海螺洗净后冷冻贮藏，取出绞碎、干燥，然后微波膨化处理，微波膨化处理的压强为0.5-1.0MPa，时间为4-6min，得到药材粉末，将药材粉末加入pH为11-12的碱性溶液后过滤，药材粉末与碱性溶液的重量体积比为1g：(2.2-3.0)mL，得到一次滤液，然后向一次滤液中进入蛋白酶溶液，蛋白酶溶液与一次滤液的体积比为1：(3-4.5)，酶解后灭活蛋白酶，过滤，得到二次滤液，向二次滤液中加入乙醇静置，乙醇与二次滤液的体积比为1：(5-6)，过滤取上清液，得到第一滤液；
破壁步骤：将党参、川芎、骨碎补、陈皮丝、小木瓜、五加皮、锁阳、红花、白芍、金樱子、天麻、巴吉、枸杞、一口钟、红枣、槟榔、穿破石、还魂草、茯苓、黄芪、栀子、鸡血藤、田七、穿山龙、威灵仙和黄连以喷雾湿润，放入破壁机中，加压至1.2-3MPa，升温至80-90℃，维持温度不变5-10s，然后瞬间减压至常压，干燥后得到破壁药材；
浸泡步骤：将破壁药材放入150-200℃的热水中浸泡1-1.5h后，过滤去渣，得到第二滤液；
混合步骤：将一次滤液和二次滤液混合，浓缩、静置、过滤，浓缩至原体积的1/6-1/4，得到治疗痛风的药酒。
对比例1：
对比例1与实施例1不同之处在于，预处理步骤为：取海龙、梅花鹿筋、海星和海螺洗净后放入白酒中，浸泡40-50天，过滤去渣，得到第一滤液。
对比例2：
对比例2与实施例1不同之处在于，破壁和浸泡步骤为：将党参、川芎、骨碎补、陈皮丝、小木瓜、五加皮、锁阳、红花、白芍、金樱子、天麻、巴吉、枸杞、一口钟、红枣、槟榔、穿破石、还魂草、茯苓、黄芪、栀子、鸡血藤、田七、穿山龙、威灵仙和黄连加5-10倍的水煎煮1-2小时，过滤去渣，得到第二滤液。
效果评价及性能检测
一、动物实验
高尿酸血症是痛风病的发病基础，体内尿酸的主要来源有两个方面，一部分是由食物中的嘌呤经酶分解代谢而来，另一部分由体内细胞分解代谢的核算和其他嘌呤类化合物分解而来。
1.1 高尿酸血症小鼠血尿酸测定实验方法
90只小鼠，体重18-22g，雌雄各半，随机分为实验一组、实验二组、实验三组、实验四组、实验五组、对比一组、对比二组、对照组和模型组，分别灌服实验一至五组的小鼠实施例1-5的药酒，对比一至二组的小鼠对比例1-2的药酒，对照组灌服生理盐水，每日一次，给药10天，末次给药30min后，将实验一至五组、对比一至二组和模型组动物腹腔注射次黄嘌呤1mg/kg造成小鼠高血尿酸，模型组在最后一次给药前一小时注射黄嘌呤1mg/kg，对照组注射等体积空白对照液。注射30min后，各组动物眼球采血，将采血以2500r/min离心15min，取血清侧血尿酸值。
1.2 高尿酸血症小鼠尿尿酸测定实验方法
90只小鼠，体重18-22g，雌雄各半，随机分为实验一组、实验二组、实验三组、实验四组、实验五组、对比一组、对比二组、对照组和模型组，分别灌服实验一至五组的小鼠实施例1-5的药酒，对比一至二组的小鼠对比例1-2的药酒，对照组灌服生理盐水，每日一次，给药10天，末次给药30min后，将实验一至五组、对比一至二组和模型组动物腹腔注射次黄嘌呤1mg/kg造成小鼠高血尿酸，对照组注射等体积空白对照液。注射次黄嘌呤的同时，小鼠灌胃1mL生理盐水，1h后收集各组动物的尿液，测定尿酸值。
实验结果利用统计学结果如表2-3所示。
表2 高尿酸血症小鼠血尿酸的影响结果
表3 高尿酸血症小鼠尿尿酸的影响结果
组别 只数 剂量(g/kg) 血尿酸值(μmol/L)
模型组 10 - 6025±1029
实验一组 10 20 5921±1012
实验二组 10 20 6189±1401
实验三组 10 20 6295±1029
实验四组 10 20 6021±1201
实验五组 10 20 6582±1034
对比一组 10 20 8125±1205
对比二组 10 20 8203±1009
对照组 10 等体积 110±31
由表2-3可见，本发明实施例1-5的药酒能明显降低血尿酸水平，对尿尿酸的作用也与模型组对比无明显差别，可见本发明的药酒有促进血液循环，调节嘌呤正常代谢，抑制尿酸的生成，促进尿酸的排泄，溶解痛风性解释的作用，但是对比例1-2的效果均差于实施例1-5，这说明本发明的制备方法对动物原料和对植物原料分别处理，均能够砳明显提高药酒的功效。
二、临床试验
案例一：张某，36岁，公务员，右足红肿、疼痛反复发作3年，在医院检验血尿酸高，右足关节肿胀呈暗红色，触痛明显。使用本药酒，涂抹至患处，10天后，不用拐杖已能行走自如，一年未见复发。
案例二：王某，59岁，个体户，第一砳趾关节双侧肿痛。每日一次服用本药酒10mL，半个月后痊愈。
案例三：成某，38岁，个体户，踝关节单侧肿痛。将患处皮肤消毒，用止血钳夹住皮试针头，露出针头约2mm，轻轻点扎患处皮肤，至皮肤稍有渗血点，待血点凝固后擦去，用砷药酒涂抹，用塑料片拍打5-10min，反复三次，每天2-3次，1h后止痛，两次即痊愈。
案例四：王某，42岁，教师，第一砳趾关节单侧肿痛。使用本药酒，涂抹至患处，5天后痊愈。
综上所述，由动物实验和临床试验结果可见，本发明的药酒能够用于预防和治疗痛风，疗效显著，能够有效避免复发，且毒副作用小。
上述实施方式仅为本发明的优选实施方式，不能以此来限定本发明保护的范围，本领域的技术人员在本发明的基础上所做的任何非实质性的变化及替换均属于本发明所要求保护的范围。

Claims (10)

1.一种治疗痛风的药酒，其特征在于，包括如下组分：
党参、海龙、梅花鹿筋、海星、海螺、川芎、骨碎补、陈皮丝、小木瓜、五加皮、锁阳、红花、白芍、金樱子、天麻、巴吉、枸杞、一口钟、红枣、槟榔、穿破石、还魂草、茯苓、黄芪、栀子、鸡血藤、田七、穿山龙、威灵仙和黄连。
2.如权利要求1所述的治疗痛风的药酒，其特征在于，以重量份计，各组分的配比如下：党参15-20份，海龙5-8份，梅花鹿筋50-80份，海星15-20份，海螺5-8份，川芎30-40份，骨碎补50-60份，陈皮丝50-60份，小木瓜100-150份，五加皮80-100份，锁阳20-30份，红花60-70份，白芍40-60份，金樱子45-50份，天麻100-120份，巴吉20-30份，枸杞50-60份，一口钟20-30份，红枣40-50份，槟榔10-15份，穿破石100-150份，还魂草30-40份，茯苓50-60份，黄芪45-60份，栀子30-40份，鸡血藤80-90份，田七100-120份，穿山龙200-250份，威灵仙100-120份，黄连50-60份。
3.一种如权利要求2所述的治疗痛风的药酒的制备方法，其特征在于包括，
预处理步骤：取海龙、梅花鹿筋、海星和海螺洗净后冷冻贮藏，取出绞碎、干燥，然后微波膨化处理，得到药材粉末，将药材粉末加入碱性溶液后过滤，得到一次滤液，然后向一次滤液中进入蛋白酶溶液，酶解后灭活蛋白酶，过滤，得到二次滤液，向二次滤液中加入乙醇静置，过滤取上清液，得到第一滤液；
破壁步骤：将党参、川芎、骨碎补、陈皮丝、小木瓜、五加皮、锁阳、红花、白芍、金樱子、天麻、巴吉、枸杞、一口钟、红枣、槟榔、穿破石、还魂草、茯苓、黄芪、栀子、鸡血藤、田七、穿山龙、威灵仙和黄连以喷雾湿润，放入破壁机中，加压、升温，维持温度不变，然后瞬间减压，干燥后得到破壁药材；
浸泡步骤：将破壁药材放入热水中浸泡后，过滤去渣，得到第二滤液；
混合步骤：将一次滤液和二次滤液混合，浓缩、静置、过滤，得到治疗痛风的药酒。
4.如权利要求3所述的治疗痛风的药酒的制备方法，其特征在于，预处理步骤中，微波膨化处理的压强为0.5-1.0MPa，时间为4-6min。
5.如权利要求3所述的治疗痛风的药酒的制备方法，其特征在于，预处理步骤中，碱性溶液的pH为11-12，药材粉末与碱性溶液的重量体积比为1g：(2.2-3.0)mL。
6.如权利要求3所述的治疗痛风的药酒的制备方法，其特征在于，预处理步骤中，蛋白酶溶液与一次滤液的体积比为1：(3-4.5)；乙醇与二次滤液的体积比为1：(5-6)。
7.如权利要求3所述的治疗痛风的药酒的制备方法，其特征在于，破壁步骤中，加压至1.2-3MPa，升温至80-90℃。
8.如权利要求3所述的治疗痛风的药酒的制备方法，其特征在于，破壁步骤中，维持温度不变5-10s，减压至常压。
9.如权利要求3所述的治疗痛风的药酒的制备方法，其特征在于，浸泡步骤中，热水的温度为150-200℃，浸泡1-1.5h。
10.如权利要求3所述的治疗痛风的药酒的制备方法，其特征在于，混合步骤中，浓缩至原体积的1/6-1/4。
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