CN109172702A - It is a kind of to alleviate the swollen eyedrops and preparation method thereof of eye acid - Google Patents
It is a kind of to alleviate the swollen eyedrops and preparation method thereof of eye acid Download PDFInfo
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- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of eyedrops that alleviation eye acid is swollen, are related to a kind of drug, it is swollen to be mainly used for the acid of eye caused by solving the problems, such as a variety of causes；The eyedrops includes the following raw material according to parts by weight: 7-11 parts of hydroxypropyl methyl cellulose, 4-9 parts of lutein ester .5-2.7 parts of retinol1,0.7-1.8 parts of vitamin E, 3-8 parts of Chinese milk vetch, 5-10 parts of dandelion, 1-4 parts of grape pip, 0.5-1.1 parts of viscosity promoting agent.The effect of eyedrops of the present invention is made by the way of Integrated TCM using modern advanced medical pharmaceutical technology, under the synergistic effect of each component, has clearing heat-fire, and spasmolysis goes screen, nourishes the liver to improve visual acuity, it is swollen effectively to alleviate eye acid, significant in efficacy.
Description
Technical field
It is specifically a kind of to alleviate the swollen eyedrops and preparation method thereof of eye acid the present invention relates to a kind of drug.
Background technique
Eyes are one of most important organs of human body, adapt to social life for people and provide guarantee.With modern artificial
Make the substantially change of property, working environment and recreation kenel, inevitably become normality using eyes for a long time,
Just because of this, modern eyes maintenance and eye disease occur and aging prevention also at getting more and more attention the problem of
One of.
Asthenopia is also known as visual fatigue, is a kind of ophthalmology common disease, and the eye caused by it is dry, eye is puckery, eye is sour swollen, blurred vision
Or even visual impairment directly affects the work and life of people.Asthenopia mainly due to people usually concentrate to see TV,
When the electronic products screen such as computer or mobile phone, eyes number of winks is reduced, and causes tears Secretion that should reduce, while flashing fluorescent screen
Caused by intense stimulus eyes.Asthenopia can also cause and aggravate various eye disease.And rely solely on rest often can not be quick
Effective alleviation eyes acid is swollen, therefore needs a kind of eyedrops, and people's rapid recovery eye acid can be helped swollen.
Summary of the invention
The purpose of the present invention is to provide a kind of eyedrops and preparation method thereof that alleviation eye acid is swollen, to solve above-mentioned back
The problem of being proposed in scape technology.
To achieve the above object, the invention provides the following technical scheme:
It is a kind of to alleviate the swollen eyedrops of eye acid, including below according to the raw material of parts by weight: hydroxypropyl methyl cellulose 7-
11 parts, 4-9 parts of lutein ester .5-2.7 parts of retinol1,0.7-1.8 parts of vitamin E, 3-8 parts of Chinese milk vetch, dandelion 5-10
Part, 1-4 parts of grape pip, 0.5-1.1 parts of viscosity promoting agent.
As a further solution of the present invention: including below according to the raw material of parts by weight: hydroxypropyl methyl cellulose 8-10
Part, 5-8 parts of lutein ester .9-2.3 parts of retinol1 .1-1.4 parts of vitamin e1,4-7 parts of Chinese milk vetch, 7-9 parts of dandelion, Portugal
2-3 parts of grape seed, 0.7-0.9 parts of viscosity promoting agent.
As further scheme of the invention: including below according to the raw material of parts by weight: hydroxypropyl methyl cellulose 9
Part, 6.5 parts of lutein ester .1 parts of dehydroretinol .3 parts of vitamin e1,5.5 parts of Chinese milk vetch, 8.5 parts of dandelion, grape pip 2.5
Part, 0.8 part of viscosity promoting agent.
As the present invention further scheme: the viscosity enhancing agent be sanlose, methylcellulose,
One of polyvinyl nafoxidine ketone or polyvinyl alcohol.
The preparation method for alleviating the swollen eyedrops of eye acid, comprising the following steps:
1) Chinese milk vetch, dandelion and grape pip are weighed, is crushed, 7-12 times of quality times of dehydrated alcohol extraction two is then added
Secondary, first time extraction temperature is that 57-69 DEG C, time 2-4h, second extraction temperature is 77-90 DEG C, merges extracting solution twice,
Then it is concentrated into the 40-55% of original volume, obtains concentrate；
2) lutein ester is dissolved in 12-17 times of quality times of distilled water, obtained solution A；
3) vitamin A and vitamin E are crushed, is added in solution A, is uniformly mixing to obtain solution B；
4) hydroxypropyl methyl cellulose is dissolved in 5-8 times of distilled water, obtained solution C；
5) solution B is heated to 72-85 DEG C, solution C is added drop-wise to solution B with 10 drops speed per minute using dropper
In, while quickly stirring, solution D is obtained after cooling；
6) merge concentrate and solution D, while viscosity enhancing agent be added, stir evenly to get.
As further scheme of the invention: the temperature of the distilled water in the step 4) is lower than 15 DEG C.
As further scheme of the invention: the rate quickly stirred in the step 5) is 800-1000rpm.
The application for alleviating the swollen eyedrops of eye acid in preparation treatment asthenopia drug.
Compared with prior art, the beneficial effects of the present invention are:
Eyedrops of the present invention is made, each by the way of Integrated TCM using modern advanced medical pharmaceutical technology
Under the synergistic effect of component, there is clearing heat-fire, the effect of spasmolysis goes screen, nourishes the liver to improve visual acuity, it is swollen effectively to alleviate eye acid,
It is significant in efficacy.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
Embodiment 1
It is a kind of to alleviate the swollen eyedrops of eye acid, including below according to the raw material of parts by weight: hydroxypropyl methyl cellulose 7
Part, 4 parts of lutein ester .5 parts of retinol1,0.7 part of vitamin E, 3 parts of Chinese milk vetch, 5 parts of dandelion, 1 part of grape pip, viscosity increase
Into 0.5 part of agent.
Wherein the viscosity enhancing agent is sanlose.
The preparation method for the eyedrops that the acid of alleviation eye described in the present embodiment is swollen, comprising the following steps:
1) Chinese milk vetch, dandelion and grape pip are weighed, is crushed, the dehydrated alcohol that 7 times of quality times is then added extracts twice,
First time extraction temperature is that 57 DEG C, time 2h, second extraction temperatures are 77 DEG C, merges extracting solution twice, is then concentrated into
The 405% of original volume, obtains concentrate；
2) lutein ester is dissolved in the distilled water of 12 times of quality times, obtained solution A；
3) vitamin A and vitamin E are crushed, is added in solution A, is uniformly mixing to obtain solution B；
4) hydroxypropyl methyl cellulose is dissolved in 5-8 times of distilled water, obtained solution C；
5) solution B is heated to 72 DEG C, is added drop-wise to solution C in solution B with 10 drops speed per minute using dropper, together
When quickly stir, obtain solution D after cooling；
6) merge concentrate and solution D, while viscosity enhancing agent be added, stir evenly to get.
The temperature of distilled water in the step 4) is lower than 15 DEG C.
The rate quickly stirred in the step 5) is 800rpm.
Embodiment 2
It is a kind of to alleviate the swollen eyedrops of eye acid, including below according to the raw material of parts by weight: hydroxypropyl methyl cellulose 8
Part, 5 parts of lutein ester .9 parts of retinol1 .1 parts of vitamin e1,4 parts of Chinese milk vetch, 7 parts of dandelion, 2 parts of grape pip, viscosity increase
Into 0.7 part of agent.
Wherein the viscosity enhancing agent is methylcellulose.
The preparation method for the eyedrops that the acid of alleviation eye described in the present embodiment is swollen, comprising the following steps:
1) Chinese milk vetch, dandelion and grape pip are weighed, is crushed, the dehydrated alcohol that 9 times of quality times is then added extracts twice,
First time extraction temperature is that 62 DEG C, time 3h, second extraction temperatures are 84 DEG C, merges extracting solution twice, is then concentrated into
The 50% of original volume, obtains concentrate；
2) lutein ester is dissolved in the distilled water of 14 times of quality times, obtained solution A；
3) vitamin A and vitamin E are crushed, is added in solution A, is uniformly mixing to obtain solution B；
4) hydroxypropyl methyl cellulose is dissolved in 6 times of distilled water, obtained solution C；
5) solution B is heated to 78 DEG C, is added drop-wise to solution C in solution B with 10 drops speed per minute using dropper, together
When quickly stir, obtain solution D after cooling；
6) merge concentrate and solution D, while viscosity enhancing agent be added, stir evenly to get.
The temperature of distilled water in the step 4) is lower than 15 DEG C.
The rate quickly stirred in the step 5) is 900rpm.
Embodiment 3
It is a kind of to alleviate the swollen eyedrops of eye acid, including below according to the raw material of parts by weight: hydroxypropyl methyl cellulose 9
Part, 6.5 parts of lutein ester .1 parts of dehydroretinol .3 parts of vitamin e1,5.5 parts of Chinese milk vetch, 8.5 parts of dandelion, grape pip 2.5
Part, 0.8 part of viscosity promoting agent.
Wherein the viscosity enhancing agent is polyvinyl nafoxidine ketone.
The preparation method for the eyedrops that the acid of alleviation eye described in the present embodiment is swollen, comprising the following steps:
1) Chinese milk vetch, dandelion and grape pip are weighed, is crushed, the dehydrated alcohol extraction two of 10 times of quality times is then added
Secondary, first time extraction temperature is that 68 DEG C, time 2.5h, second extraction temperatures are 85 DEG C, merges extracting solution twice, then dense
It is reduced to the 45% of original volume, obtains concentrate；
2) lutein ester is dissolved in the distilled water of 14 times of quality times, obtained solution A；
3) vitamin A and vitamin E are crushed, is added in solution A, is uniformly mixing to obtain solution B；
4) hydroxypropyl methyl cellulose is dissolved in 6 times of distilled water, obtained solution C；
5) solution B is heated to 79 DEG C, is added drop-wise to solution C in solution B with 10 drops speed per minute using dropper, together
When quickly stir, obtain solution D after cooling；
6) merge concentrate and solution D, while viscosity enhancing agent be added, stir evenly to get.
The temperature of distilled water in the step 4) is lower than 15 DEG C.
The rate quickly stirred in the step 5) is 950rpm.
Embodiment 4
It is a kind of to alleviate the swollen eyedrops of eye acid, including below according to the raw material of parts by weight: hydroxypropyl methyl cellulose 10
Part, 8 parts of lutein ester .3 parts of dehydroretinol .4 parts of vitamin e1,7 parts of Chinese milk vetch, 9 parts of dandelion, 3 parts of grape pip, viscosity increase
Into 0.9 part of agent.
Wherein the viscosity enhancing agent is polyvinyl alcohol.
The preparation method for the eyedrops that the acid of alleviation eye described in the present embodiment is swollen, comprising the following steps:
1) Chinese milk vetch, dandelion and grape pip are weighed, is crushed, the dehydrated alcohol extraction two of 11 times of quality times is then added
Secondary, first time extraction temperature is that 66 DEG C, time 3.5h, second extraction temperatures are 86 DEG C, merges extracting solution twice, then dense
It is reduced to the 50% of original volume, obtains concentrate；
2) lutein ester is dissolved in the distilled water of 16 times of quality times, obtained solution A；
3) vitamin A and vitamin E are crushed, is added in solution A, is uniformly mixing to obtain solution B；
4) hydroxypropyl methyl cellulose is dissolved in 7 times of distilled water, obtained solution C；
5) solution B is heated to 80 DEG C, is added drop-wise to solution C in solution B with 10 drops speed per minute using dropper, together
When quickly stir, obtain solution D after cooling；
6) merge concentrate and solution D, while viscosity enhancing agent be added, stir evenly to get.
The temperature of distilled water in the step 4) is lower than 15 DEG C.
The rate quickly stirred in the step 5) is 900rpm.
Embodiment 5
It is a kind of to alleviate the swollen eyedrops of eye acid, including below according to the raw material of parts by weight: hydroxypropyl methyl cellulose 11
Part, 9 parts of lutein ester .7 parts of dehydroretinol .8 parts of vitamin e1,8 parts of Chinese milk vetch, 10 parts of dandelion, 4 parts of grape pip, viscosity
1.1 parts of promoting agent.
Wherein the viscosity enhancing agent is polyvinyl nafoxidine ketone.
The preparation method for the eyedrops that the acid of alleviation eye described in the present embodiment is swollen, comprising the following steps:
1) Chinese milk vetch, dandelion and grape pip are weighed, is crushed, the dehydrated alcohol extraction two of 12 times of quality times is then added
Secondary, first time extraction temperature is that 69 DEG C, time 4h, second extraction temperatures are 90 DEG C, merges extracting solution twice, is then concentrated
To the 55% of original volume, concentrate is obtained；
2) lutein ester is dissolved in the distilled water of 17 times of quality times, obtained solution A；
3) vitamin A and vitamin E are crushed, is added in solution A, is uniformly mixing to obtain solution B；
4) hydroxypropyl methyl cellulose is dissolved in 8 times of distilled water, obtained solution C；
5) solution B is heated to 85 DEG C, is added drop-wise to solution C in solution B with 10 drops speed per minute using dropper, together
When quickly stir, obtain solution D after cooling；
6) merge concentrate and solution D, while viscosity enhancing agent be added, stir evenly to get.
The temperature of distilled water in the step 4) is lower than 15 DEG C.
The rate quickly stirred in the step 5) is 1000rpm.
Comparative example 1
Compared with Example 3, lutein ester is free of, other are same as Example 3.
Comparative example 2
Compared with Example 3, Chinese milk vetch is free of, other are same as Example 3.
Comparative example 3
Compared with Example 3, lutein ester and Chinese milk vetch are free of, other are same as Example 3.
Clinical test
1, case selection: patient 160 with the swollen symptom of eye acid of selection, the age 10-55 years old, wherein 80 people of male,
80 people of women is randomly divided into 8 groups, every group of 20 people, respectively using eyedrops corresponding to embodiment 1-6 and comparative example 1-3.
2, application method: 3-5 times on the one, a 2-3 drop.
3, curative effect judging standard
Effective: eye visual restores completely, and acid is swollen, and symptom is cured；
Effective: eye acid is swollen to be alleviated；
Invalid: illness is unchanged.
4, statistical result see the table below
5, conclusion
As can be seen from the above table, the curative effect of embodiment 1-6 is substantially better than comparative example 1-3, illustrates that the present invention is in each component
Synergistic effect is lower to play effect, can be seen that building component lutein in combination with the data of comparative example 1-2 and comparative example 3
Ester and Chinese milk vetch play particularly important effect in the present invention.
Typical case
One, poplar, male, 18 years old, student often found out because study is nervous to the late into the night, caused eye congested while adjoint
The swollen phenomenon of acid, using the eyedrops of the embodiment of the present invention 3, can rapid recovery eye acid it is swollen, adhere to using after 1 month, eye
Portion's swollen phenomenon of acid fades away.
Two, Lee, female, 36 years old, advanced white collar was often worked extra shifts or extra hours, too long in face of machine time, caused eye regular
Acid it is swollen, after the eyedrops using the embodiment of the present invention 5, can rapid recovery eye acid it is swollen, adhere to using after 2 months, eye
Acid is swollen, and phenomenon fades away.
Three, Guo, male, 48 years old, night market booth retailer worked under dim light environment throughout the year, causes eye regular
Acid it is swollen, while eyesight is decreased obviously, after the eyedrops using the embodiment of the present invention 2, can rapid recovery eye acid it is swollen, adhere to
After 1 month, eye acid is swollen, and phenomenon fades away, while eyesight is restored.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (8)
1. a kind of alleviate the swollen eyedrops of eye acid, which is characterized in that including below according to the raw material of parts by weight: hydroxypropyl methyl
7-11 parts of cellulose, 4-9 parts of lutein ester .5-2.7 parts of retinol1,0.7-1.8 parts of vitamin E, 3-8 parts of Chinese milk vetch, Pu Gong
5-10 parts of English, 1-4 parts of grape pip, 0.5-1.1 parts of viscosity promoting agent.
2. according to claim 1 alleviate the swollen eyedrops of eye acid, which is characterized in that including below according to parts by weight
Raw material: 8-10 parts of hydroxypropyl methyl cellulose, 5-8 parts of lutein ester .9-2.3 parts of retinol1 .1-1.4 parts of vitamin e1,
4-7 parts of Chinese milk vetch, 7-9 parts of dandelion, 2-3 parts of grape pip, 0.7-0.9 parts of viscosity promoting agent.
3. according to claim 1 alleviate the swollen eyedrops of eye acid, which is characterized in that including below according to parts by weight
Raw material: 9 parts of hydroxypropyl methyl cellulose, 6.5 parts of lutein ester .1 parts of dehydroretinol .3 parts of vitamin e1,5.5 parts of Chinese milk vetch,
8.5 parts of dandelion, 2.5 parts of grape pip, 0.8 part of viscosity promoting agent.
4. according to claim 1 alleviate the swollen eyedrops of eye acid, which is characterized in that the viscosity enhancing agent is carboxylic first
One of base cellulose sodium salt, methylcellulose, polyvinyl nafoxidine ketone or polyvinyl alcohol.
5. a kind of preparation method for alleviating the swollen eyedrops of eye acid as described in claim 1-4 is any, which is characterized in that packet
Include following steps:
1) Chinese milk vetch, dandelion and grape pip are weighed, is crushed, 7-12 times of quality times of dehydrated alcohol is then added and extracts twice,
First time extraction temperature is that 57-69 DEG C, time 2-4h, second extraction temperature is 77-90 DEG C, merges extracting solution twice, so
It is concentrated into the 40-55% of original volume afterwards, obtains concentrate；
2) lutein ester is dissolved in 12-17 times of quality times of distilled water, obtained solution A；
3) vitamin A and vitamin E are crushed, is added in solution A, is uniformly mixing to obtain solution B；
4) hydroxypropyl methyl cellulose is dissolved in 5-8 times of distilled water, obtained solution C；
5) solution B is heated to 72-85 DEG C, is added drop-wise to solution C in solution B with 10 drops speed per minute using dropper, together
When quickly stir, obtain solution D after cooling；
6) merge concentrate and solution D, while viscosity enhancing agent be added, stir evenly to get.
6. the preparation method according to claim 5 for alleviating the swollen eyedrops of eye acid, which is characterized in that the step 4)
In distilled water temperature be lower than 15 DEG C.
7. the preparation method according to claim 5 for alleviating the swollen eyedrops of eye acid, which is characterized in that the step 5)
In the rate that quickly stirs be 800-1000rpm.
8. the sour swollen eyedrops of alleviation eye the answering in preparation treatment asthenopia drug as described in claim 1-4 is any
With.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811259491.6A CN109172702A (en) | 2018-10-26 | 2018-10-26 | It is a kind of to alleviate the swollen eyedrops and preparation method thereof of eye acid |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811259491.6A CN109172702A (en) | 2018-10-26 | 2018-10-26 | It is a kind of to alleviate the swollen eyedrops and preparation method thereof of eye acid |
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| Publication Number | Publication Date |
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| CN109172702A true CN109172702A (en) | 2019-01-11 |
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| CN201811259491.6A Withdrawn CN109172702A (en) | 2018-10-26 | 2018-10-26 | It is a kind of to alleviate the swollen eyedrops and preparation method thereof of eye acid |
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| CN (1) | CN109172702A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111803537A (en) * | 2020-07-30 | 2020-10-23 | 重庆康视美科技有限公司 | Medical and health care double-effect eye health nutrient solution and preparation method thereof |
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| US20020055471A1 (en) * | 2000-08-31 | 2002-05-09 | Bailey David T. | Efficient method for producing compositions enriched in anthocyanins |
| CN104887781A (en) * | 2015-06-18 | 2015-09-09 | 中南大学 | Eye-drops for relieving xerophthalmia and preparation method of eye-drops |
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| US20020055471A1 (en) * | 2000-08-31 | 2002-05-09 | Bailey David T. | Efficient method for producing compositions enriched in anthocyanins |
| CN104887781A (en) * | 2015-06-18 | 2015-09-09 | 中南大学 | Eye-drops for relieving xerophthalmia and preparation method of eye-drops |
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| CN111803537A (en) * | 2020-07-30 | 2020-10-23 | 重庆康视美科技有限公司 | Medical and health care double-effect eye health nutrient solution and preparation method thereof |
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Application publication date: 20190111 |