CN109157742B - 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法 - Google Patents

用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法 Download PDF

Info

Publication number
CN109157742B
CN109157742B CN201810714885.XA CN201810714885A CN109157742B CN 109157742 B CN109157742 B CN 109157742B CN 201810714885 A CN201810714885 A CN 201810714885A CN 109157742 B CN109157742 B CN 109157742B
Authority
CN
China
Prior art keywords
capsule
intestinal tract
cells
electrodes
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201810714885.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN109157742A (zh
Inventor
米尔·伊姆兰
米尔·哈什姆
艾米丽·安斯多夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incube Laboratories LLC
Original Assignee
Incube Laboratories LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incube Laboratories LLC filed Critical Incube Laboratories LLC
Publication of CN109157742A publication Critical patent/CN109157742A/zh
Application granted granted Critical
Publication of CN109157742B publication Critical patent/CN109157742B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A61N1/0509—Stomach and intestinal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
CN201810714885.XA 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法 Active CN109157742B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US27338909P 2009-08-03 2009-08-03
US61/273,389 2009-08-03
PCT/US2010/044265 WO2011017335A1 (en) 2009-08-03 2010-08-03 Swallowable capsule and method for stimulating incretin production within the intestinal tract
CN201080034437.7A CN102770151B (zh) 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201080034437.7A Division CN102770151B (zh) 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法

Publications (2)

Publication Number Publication Date
CN109157742A CN109157742A (zh) 2019-01-08
CN109157742B true CN109157742B (zh) 2022-04-05

Family

ID=43544631

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201810714885.XA Active CN109157742B (zh) 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法
CN201080034437.7A Expired - Fee Related CN102770151B (zh) 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201080034437.7A Expired - Fee Related CN102770151B (zh) 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法

Country Status (6)

Country Link
US (10) US8682440B2 (cg-RX-API-DMAC7.html)
EP (2) EP2461818B1 (cg-RX-API-DMAC7.html)
JP (8) JP5854513B2 (cg-RX-API-DMAC7.html)
CN (2) CN109157742B (cg-RX-API-DMAC7.html)
AU (2) AU2010279575B2 (cg-RX-API-DMAC7.html)
WO (1) WO2011017335A1 (cg-RX-API-DMAC7.html)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8682440B2 (en) 2009-08-03 2014-03-25 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US8721620B2 (en) 2009-12-24 2014-05-13 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
CN105168174B (zh) * 2010-03-10 2019-01-08 拉尼医疗有限公司 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
WO2013143603A1 (en) * 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
US20140051924A1 (en) * 2012-08-16 2014-02-20 Capso Vision, Inc In Vivo Capsule Device with Electrodes
WO2015042558A1 (en) * 2013-09-23 2015-03-26 Board Of Regents, The University Of Texas System Wireless tissue stimulation devices
US10689460B2 (en) 2014-05-15 2020-06-23 Incube Labs, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
WO2015176031A2 (en) 2014-05-15 2015-11-19 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
US9919152B2 (en) * 2014-11-05 2018-03-20 Enterastim, Inc. Conditional gastrointestinal stimulation for improved motility
US20160183878A1 (en) * 2014-12-27 2016-06-30 John C. Weast Technologies for managing device functions of an ingestible computing device
US10500127B2 (en) * 2016-04-18 2019-12-10 Ankon Medical Technologies (Shanghai) Co., Ltd. Vivo device and method of using the same
WO2018026720A1 (en) * 2016-07-31 2018-02-08 Hans Gregersen Autoexpandable devices for obtaining impedance, pressure, and other measurements in the gastrointestinal tract and other organs
EP3296727B1 (en) * 2016-09-19 2019-04-17 Murata Integrated Passive Solutions Electrical stimulation and monitoring device
IL250090B (en) 2017-01-12 2018-10-31 Melcap Systems Ltd A capsule is intended for ingestion by a subject and a system is intended for the digestive system
US11207272B2 (en) 2017-05-17 2021-12-28 Massachusetts Institute Of Technology Tissue anchoring articles
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
CN108742590A (zh) * 2018-04-08 2018-11-06 南京宽诚科技有限公司 一种胃肠电信号的采集方法、装置、采集设备及存储介质
US11202903B2 (en) 2018-05-17 2021-12-21 Massachusetts Institute Of Technology Systems for electrical stimulation
WO2019227150A1 (en) * 2018-05-31 2019-12-05 Neuroscience Research Australia (Neura) Systems, devices and methods for the treatment of oral and pharyngeal disorders
CN109498989A (zh) * 2018-12-20 2019-03-22 宁波贝思转化医学研究中心有限公司 一种用于判断胃肠电刺激是否有效的装置及其使用方法
JP2020108458A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2020108456A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2020108454A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2020108457A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection
MX2021010450A (es) 2019-03-01 2021-12-10 Rani Therapeutics Llc Dispositivos, sistemas y métodos para administrar agentes terapéuticos en la pared de un estómago.
US20230317230A1 (en) * 2019-05-02 2023-10-05 Closed Loop Medicine Ltd. Method for treating obesity
JP7291896B2 (ja) * 2019-09-24 2023-06-16 パナソニックIpマネジメント株式会社 レシピ出力方法、レシピ出力システム
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
KR102608853B1 (ko) * 2021-11-15 2023-12-01 재단법인 아산사회복지재단 대사질환 개선용 생체발광 캡슐
US20240415429A1 (en) * 2023-06-14 2024-12-19 University Of Maryland, College Park Real-time ingestible sensing capsule

Family Cites Families (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788322A (en) 1972-12-27 1974-01-29 Alza Corp Drug delivery device with means for maintaining device in environment of use
US4249531A (en) 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
DE2928477C3 (de) 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
JPS60129057A (ja) 1983-12-14 1985-07-10 住友化学工業株式会社 針状固形製剤投与針
US4596819A (en) 1984-01-23 1986-06-24 Warner-Lambert Company Modified tripeptides
US4663308A (en) 1984-07-18 1987-05-05 Medical College Of Ohio Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract
FR2597351B1 (fr) 1986-04-16 1994-03-25 Celsa Composants Electriques Capsule distributrice de drogue implantable et procede et dispositif facilitant son utilisation.
US5137669A (en) 1988-03-02 1992-08-11 Endocon, Inc. Manufacture of partially fused peptide pellet
JP2691937B2 (ja) 1988-07-05 1997-12-17 カンテニース,ジョゼ 胃内バルーン
US5271945A (en) 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
US5474785A (en) 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5217449A (en) 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
PT100944B (pt) 1991-10-10 2000-02-29 Alza Corp Dispositivo para o fornecimento osmotico de farmacos com paredes de materiais hidrofobicos
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
DK42093D0 (da) 1993-04-07 1993-04-07 Bukh Meditec Administrationsmetode
US5437291A (en) 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
US5652216A (en) 1994-05-26 1997-07-29 Novo Nordisk A/S Pharmaceutical preparation
US5849327A (en) 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
US5904935A (en) 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5750926A (en) 1995-08-16 1998-05-12 Alfred E. Mann Foundation For Scientific Research Hermetically sealed electrical feedthrough for use with implantable electronic devices
US5620476A (en) 1995-11-13 1997-04-15 Pacesetter, Inc. Implantable medical device having shielded and filtered feedthrough assembly and methods for making such assembly
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5987358A (en) 1998-02-17 1999-11-16 Intermedics, Inc. Semiconductor device packaging and method of fabrication
IT1299266B1 (it) 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US6395273B1 (en) 1998-06-10 2002-05-28 Promega Corporation Prevention and treatment of inflammatory bowel disease
US8700161B2 (en) * 1999-03-05 2014-04-15 Metacure Limited Blood glucose level control
AU2937600A (en) * 1999-03-05 2000-09-28 Impulse Dynamics N.V. Blood glucose level control
WO2004112563A2 (en) * 2003-06-20 2004-12-29 Metacure N.V., Gastrointestinal methods and apparatus for use in treating disorders
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6832114B1 (en) * 2000-11-21 2004-12-14 Advanced Bionics Corporation Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes
US6638246B1 (en) 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
EP1345968A2 (en) 2000-12-28 2003-09-24 Altus Biologics Inc. Crystals of whole antibodies and fragments thereof and methods for making and using them
US7069081B2 (en) 2001-02-08 2006-06-27 Wilson Greatbatch Ltd. One piece header assembly for an implantable medical device
EP1386155A4 (en) 2001-04-10 2006-05-10 Univ Leland Stanford Junior THERAPEUTIC AND DIAGNOSTIC USE OF ANTIBODY SPECIFICITY PROFILES
US7787958B2 (en) 2001-04-13 2010-08-31 Greatbatch Ltd. RFID detection and identification system for implantable medical lead systems
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
US7083578B2 (en) 2001-07-12 2006-08-01 Given Imaging Ltd. Device and method for examining a body lumen
US20070162085A1 (en) * 2001-07-23 2007-07-12 Dilorenzo Biomedical, Llc Method, apparatus, surgical technique, and stimulation parameters for autonomic neuromodulation for the treatment of obesity
US20030226155A1 (en) 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
JP4643089B2 (ja) 2001-09-27 2011-03-02 オリンパス株式会社 カプセル型医療装置
JP2002186672A (ja) 2001-09-28 2002-07-02 Olympus Optical Co Ltd 医療用カプセル装置
WO2003028653A2 (en) 2001-10-03 2003-04-10 Glaxo Group Limited Sustained release pharmaceutical compositions
US6656155B2 (en) 2001-12-17 2003-12-02 Scimed Life Systems, Inc. Catheter for endoluminal delivery of therapeutic agents that minimizes loss of therapeutic
FR2835730B1 (fr) 2002-02-11 2004-12-10 C T M Ct De Transfert Des Micr Dispositif pour la delivrance de substances et le prelevement intracorporel
US20030186892A1 (en) 2002-03-28 2003-10-02 Rajneesh Taneja Enhancement of endogenous gonadotropin production
AU2003275311A1 (en) 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
AU2002951739A0 (en) 2002-09-30 2002-10-17 Cochlear Limited Feedthrough with multiple conductive pathways extending therethrough
US20040106904A1 (en) 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
US20040093039A1 (en) * 2002-10-25 2004-05-13 Raphael Schumert Gastrointestinal pacemaker
ATE547976T1 (de) 2002-12-26 2012-03-15 Given Imaging Ltd Immobilisierbare in-vivo messvorrichtung
US20040143221A1 (en) 2002-12-27 2004-07-22 Shadduck John H. Biomedical implant for sustained agent release
CA2514392A1 (en) 2003-01-29 2004-08-12 E-Pill Pharma Ltd. Active drug delivery in the gastrointestinal tract
US20050058701A1 (en) 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20040267240A1 (en) 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
JP2005021677A (ja) 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベース、及び注射針
JP2007525472A (ja) 2003-07-04 2007-09-06 ニコメド ダンマーク エイピーエス 経口使用のための副甲状腺ホルモン(pth)含有医薬組成物
US20070060971A1 (en) * 2003-07-21 2007-03-15 Ofer Glasberg Hepatic device for treatment or glucose detection
SG145712A1 (en) 2003-08-01 2008-09-29 Amgen Inc Crystalline tumor necrosis factor receptor 2 polypeptides
US20050038415A1 (en) 2003-08-06 2005-02-17 Rohr William L. Method and apparatus for the treatment of obesity
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
AU2004277419B2 (en) 2003-09-30 2007-10-11 Brown University Research Foundation Nanoparticulate therapeutic biologically active agents
US20050124875A1 (en) 2003-10-01 2005-06-09 Olympus Corporation Vivo observation device
JP4733918B2 (ja) 2003-10-01 2011-07-27 オリンパス株式会社 カプセル投薬システム
JP2007526022A (ja) 2003-10-24 2007-09-13 メドトロニック・インコーポレーテッド 炎症誘発性媒介物質の産生を減弱することによって神経性障害を処置する技法
US7918786B2 (en) * 2003-11-11 2011-04-05 Olympus Corporation Capsule type medical device system, and capsule type medical device
JP2005143560A (ja) * 2003-11-11 2005-06-09 Olympus Corp カプセル型医療装置
JP4094543B2 (ja) * 2003-12-26 2008-06-04 オリンパス株式会社 カプセル型医療装置システム
US20050158356A1 (en) 2003-11-20 2005-07-21 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US8585771B2 (en) 2004-02-26 2013-11-19 Endosphere, Inc. Methods and devices to curb appetite and/or to reduce food intake
MY162179A (en) 2004-04-01 2017-05-31 Elan Pharm Inc Steroid sparing agents and methods of using same
US7857767B2 (en) 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
DE102004026615A1 (de) 2004-06-01 2005-12-29 Siemens Ag Vorrichtung und Verfahren zur Freisetzung eines in das Körperinnere eines Patienten geführten therapeutischen Mittels
JP2006000307A (ja) 2004-06-16 2006-01-05 Pentax Corp 酸素発生装置を有するカプセル型医療用具
US20060153894A1 (en) 2004-06-30 2006-07-13 Ragae Ghabrial Multi-compartment delivery system
CN105708787A (zh) 2004-07-12 2016-06-29 爱密斯菲尔科技公司 用于递送肽yy和pyy激动剂的组合物
EP1796529B1 (en) 2004-09-08 2016-02-03 Olympus Corporation Capsule type medical device
US20060063719A1 (en) 2004-09-21 2006-03-23 Point Therapeutics, Inc. Methods for treating diabetes
WO2006035446A2 (en) 2004-09-30 2006-04-06 Duocure, Inc. Device and method for treating weight disorders
EP1827387A2 (en) 2004-12-14 2007-09-05 E-Pill Pharma Ltd. Prolonged transit time of permeability-enhancing drug eluting pill
WO2006074051A2 (en) 2004-12-30 2006-07-13 Diakine Therapeutics, Inc. PHARMACEUTICAL COMPOSITIONS AND METHODS FOR RESTORING β-CELL MASS AND FUNCTION
US7556826B2 (en) 2005-01-04 2009-07-07 Gp Medical, Inc. Nanoparticles for protein drug delivery
CN101107038A (zh) 2005-01-18 2008-01-16 皇家飞利浦电子股份有限公司 电控胶囊
US7785291B2 (en) 2005-03-01 2010-08-31 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
CN2860501Y (zh) 2005-03-10 2007-01-24 李华 一次性注射器
EP1885437A2 (en) * 2005-05-19 2008-02-13 E-Pill Pharma Ltd. Ingestible device for nitric oxide production in tissue
CN101184523B (zh) 2005-05-27 2011-04-13 奥林巴斯株式会社 被检体内导入装置
US20070016262A1 (en) * 2005-07-13 2007-01-18 Betastim, Ltd. Gi and pancreatic device for treating obesity and diabetes
EP1906830B1 (en) 2005-07-26 2013-09-04 Ram Weiss Extending intrabody capsule
US8021384B2 (en) 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
PL2347762T3 (pl) 2005-08-19 2019-09-30 Amylin Pharmaceuticals, Llc Eksendyna do leczenia cukrzycy i zmniejszania masy ciała
AU2006292293B2 (en) 2005-09-19 2012-09-13 Isis Pharmaceuticals, Inc. Modulation of glucocorticoid receptor expression
US7957796B2 (en) * 2005-10-28 2011-06-07 Cyberonics, Inc. Using physiological sensor data with an implantable medical device
JP4402648B2 (ja) 2005-12-16 2010-01-20 オリンパス株式会社 被検体内導入装置
GB0603252D0 (en) 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
HUE047230T2 (hu) 2006-02-28 2020-04-28 Biogen Ma Inc Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei
US20060229529A1 (en) 2006-03-30 2006-10-12 Wright Robert C System, apparatus, and method for marking orientation of a tissue sample
US7818876B2 (en) 2006-04-25 2010-10-26 Gregg Jorgen Suaning Method for fabrication of hermetic electrical conductor feedthroughs
WO2007136735A2 (en) 2006-05-18 2007-11-29 Tulip Medical Ltd. Bioerodible self-deployable intragastric and non-gastric implants
US20070288033A1 (en) 2006-06-09 2007-12-13 Allergan, Inc. Intragastric balloon retrieval mechanisms
EP2684895A1 (en) 2006-10-27 2014-01-15 AbbVie Biotechnology Ltd Crystalline anti-hTNFalpha antibodies
EP2101643B1 (en) 2006-10-31 2013-04-24 Medimetrics Personalized Drug Delivery B.V. Design of swallowable multi-nozzle, dosing device for releasing medicines in the gastrointestinal tract
US20080214919A1 (en) 2006-12-26 2008-09-04 Lifescan, Inc. System and method for implementation of glycemic control protocols
WO2008100974A2 (en) 2007-02-13 2008-08-21 Sharma Virender K Method and apparatus for electrical stimulation of the pancreatico-biliary system
US8160708B2 (en) 2007-04-11 2012-04-17 Pacesetter, Inc. Capacitor-integrated feedthrough assembly with improved grounding for an implantable medical device
US20080260820A1 (en) 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
EP2157967B1 (en) 2007-04-23 2013-01-16 Intarcia Therapeutics, Inc Suspension formulations of insulinotropic peptides and uses thereof
US9364666B2 (en) 2007-05-07 2016-06-14 Transtimulation Research, Inc. Method of using a gastrointestinal stimulator device for digestive and eating disorders
US7925351B2 (en) * 2007-06-13 2011-04-12 Betastim, Ltd. Gastrointestinal device for treating obesity and diabetes
US20090030743A1 (en) 2007-07-24 2009-01-29 Las Vegas Central Reservation Corp. Intelligent Hotel Reservation System and Method
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US7930033B2 (en) 2007-08-17 2011-04-19 Jianfeng Chen Appendicular and rectal stimulator device for digestive and eating disorders
CN101808567B (zh) 2007-09-26 2012-09-05 奥林巴斯医疗株式会社 被检体内导入系统
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
US8215013B2 (en) 2008-04-11 2012-07-10 Bal Seal Engineering, Inc. Method for making a free standing axially compressed connector stack
WO2009129465A2 (en) 2008-04-17 2009-10-22 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of xbp-1 gene
CA2723434C (en) 2008-05-05 2018-01-23 Oramed Ltd. Methods and compositions for oral administration of exenatide
ATE505128T1 (de) 2008-06-04 2011-04-15 Olympus Medical Systems Corp Kapselförmige medizinische vorrichtung
US20090317372A1 (en) 2008-06-20 2009-12-24 Zoltan Kiss Small molecules for the reduction of high blood glucose level
US8287902B2 (en) 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
BRPI0917925A2 (pt) 2008-08-26 2015-11-10 Centocor Ortho Biotech Inc estimulação da liberação de hormônio da saciedade
US8948870B2 (en) 2008-09-09 2015-02-03 Incube Labs, Llc Energy harvesting mechanism
EP2344459B1 (en) 2008-09-25 2013-12-25 F. Hoffmann-La Roche AG 2,3-substituted indazole or 4,5,6,7-tetrahydro-indazoles as fxr modulators against dyslipidemia and related diseases
US8535260B2 (en) 2008-10-15 2013-09-17 Dtherapeutics, Llc Devices, systems, and methods for localized drug delivery
US9072583B2 (en) 2008-10-16 2015-07-07 Obalon Therapeutics, Inc. Intragastric volume-occupying device and method for fabricating same
WO2010045656A2 (en) 2008-10-17 2010-04-22 Nectid, Inc. Novel sglt2 inhibitor dosage forms
EP2351511B1 (en) 2008-11-13 2014-04-02 Olympus Medical Systems Corp. Capsule medical apparatus
US20100131043A1 (en) 2008-11-26 2010-05-27 Casas Jesus W Endoluminal Implants For Bioactive Material Delivery
WO2010093834A2 (en) 2009-02-12 2010-08-19 Incube Labs, Llc Skin penetrating device and method for subcutaneous solid drug delivery
EP2440210A4 (en) 2009-06-12 2014-01-29 Meritage Pharma Inc METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES
US8682440B2 (en) 2009-08-03 2014-03-25 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US8721620B2 (en) 2009-12-24 2014-05-13 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
CN102905753B (zh) 2009-12-24 2016-06-29 因卡伯实验室有限责任公司 可吞咽式药剂递送装置和药剂递送方法
CN105168174B (zh) 2010-03-10 2019-01-08 拉尼医疗有限公司 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂
US20110295178A1 (en) 2010-05-26 2011-12-01 Albrecht Thomas E Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods
US8876761B2 (en) 2010-05-26 2014-11-04 Ethicon Endo-Surgery, Inc. Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods
US8603023B2 (en) 2010-05-26 2013-12-10 Ethicon Endo-Surgery, Inc. Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods
US20110295337A1 (en) 2010-05-26 2011-12-01 Albrecht Thomas E Systems and Methods For Regulating Metabolic Hormone Producing Tissue
WO2012035559A2 (en) 2010-09-17 2012-03-22 Panacea Biotec Ltd Sustained release pharmaceutical compositions comprising pregabalin
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN103987422B (zh) 2011-06-29 2017-02-15 拉尼医疗有限公司 用于治疗化合物的口服递送的装置、系统和方法
ES2773115T3 (es) 2011-06-29 2020-07-09 Rani Therapeutics Llc Preparados de agentes terapéuticos para la administración hacia el interior de una luz del tubo intestinal utilizando un dispositivo tragable para la administración de fármacos
WO2013143599A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders.
WO2013143609A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
US9750660B2 (en) 2012-03-30 2017-09-05 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
WO2013143603A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
WO2013143600A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders.
WO2013165964A1 (en) 2012-04-30 2013-11-07 Carnegie Mellon University An ingestible, electrical device for stimulating tissues in a gastrointestinal tract of an organism
US8755888B2 (en) 2012-10-17 2014-06-17 Melcap Systems Ltd. Gastrointestinal system
US9168000B2 (en) 2013-03-13 2015-10-27 Ethicon Endo-Surgery, Inc. Meal detection devices and methods
EP3964190A1 (en) 2013-03-15 2022-03-09 Rani Therapeutics, LLC Device for oral delivery of therapeutic compounds
WO2017002104A1 (en) 2015-06-28 2017-01-05 Yaron Ilan Devices for gastrointestinal stimulation and uses thereof
WO2017004623A1 (en) 2015-07-02 2017-01-05 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN105997466B (zh) 2016-06-16 2018-01-26 中南民族大学 智能型振动电子胶囊
WO2018026720A1 (en) 2016-07-31 2018-02-08 Hans Gregersen Autoexpandable devices for obtaining impedance, pressure, and other measurements in the gastrointestinal tract and other organs
IL250090B (en) 2017-01-12 2018-10-31 Melcap Systems Ltd A capsule is intended for ingestion by a subject and a system is intended for the digestive system
WO2018146675A1 (en) 2017-02-07 2018-08-16 Yaron Ilan Closed loop organ stimulation
US11202903B2 (en) 2018-05-17 2021-12-21 Massachusetts Institute Of Technology Systems for electrical stimulation
US20230284929A1 (en) 2022-03-14 2023-09-14 Massachusetts Institute Of Technology Vibrating Ingestible Capsule

Also Published As

Publication number Publication date
JP7788058B2 (ja) 2025-12-18
EP2461818A4 (en) 2013-07-24
US12403308B2 (en) 2025-09-02
US20220379113A1 (en) 2022-12-01
US20170028195A1 (en) 2017-02-02
JP2017121487A (ja) 2017-07-13
EP3466438A1 (en) 2019-04-10
AU2016203077A1 (en) 2016-06-02
EP2461818A1 (en) 2012-06-13
CN102770151B (zh) 2018-07-31
US20140163637A1 (en) 2014-06-12
US9403002B2 (en) 2016-08-02
JP2020032236A (ja) 2020-03-05
JP7341297B2 (ja) 2023-09-08
AU2016203077B2 (en) 2017-12-07
US20150174400A1 (en) 2015-06-25
JP5854513B2 (ja) 2016-02-09
AU2010279575B2 (en) 2016-05-05
US20140243921A1 (en) 2014-08-28
US11872396B2 (en) 2024-01-16
US20260199673A1 (en) 2026-07-16
JP2022166189A (ja) 2022-11-01
WO2011017335A1 (en) 2011-02-10
EP2461818B1 (en) 2018-10-17
AU2010279575A1 (en) 2012-03-01
JP2025061805A (ja) 2025-04-11
US9643005B2 (en) 2017-05-09
JP2015042285A (ja) 2015-03-05
US20170216589A1 (en) 2017-08-03
CN109157742A (zh) 2019-01-08
US8781591B2 (en) 2014-07-15
CN102770151A (zh) 2012-11-07
US8958879B2 (en) 2015-02-17
US20110208270A1 (en) 2011-08-25
JP2013501060A (ja) 2013-01-10
US9987487B2 (en) 2018-06-05
US8682440B2 (en) 2014-03-25
JP7143539B2 (ja) 2022-09-28
US20190388682A1 (en) 2019-12-26
US20240100331A1 (en) 2024-03-28
JP2023154029A (ja) 2023-10-18
JP2022058814A (ja) 2022-04-12
US11439817B2 (en) 2022-09-13

Similar Documents

Publication Publication Date Title
JP7788058B2 (ja) 腸管内でインクレチン生産を刺激するための嚥下可能カプセルおよび方法
US8934975B2 (en) Gastrointestinal electrical therapy
EP1868679B1 (en) Non-immediate effects of therapy
JP2013501060A5 (cg-RX-API-DMAC7.html)
EP1735047A2 (en) Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar
WO2006087717A2 (en) Non-immediate effects of therapy

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant