CN109142769A - A kind of reaction tray component, analysis instrument and its analysis method - Google Patents
A kind of reaction tray component, analysis instrument and its analysis method Download PDFInfo
- Publication number
- CN109142769A CN109142769A CN201811110299.0A CN201811110299A CN109142769A CN 109142769 A CN109142769 A CN 109142769A CN 201811110299 A CN201811110299 A CN 201811110299A CN 109142769 A CN109142769 A CN 109142769A
- Authority
- CN
- China
- Prior art keywords
- container
- sample
- several
- containers
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
Abstract
The invention discloses a kind of reaction tray component, analysis instrument and its analysis method, the reaction tray component includes: to be incubated for disk and several tray samples；Several the first containers for carrying determinand, the rounded distribution of several the first containers, wherein several second containers being arranged in each tray sample are arc-shaped distribution are provided on the incubation disk；It is round where several described second containers that there are several first common points with circle where several described the first containers, sampling apparatus is provided in each tray sample, the sampling apparatus rotates centered on the central axis of circle where described several second containers, and by the second container sample or reagent fill into the first container on corresponding first common point.It due to several tray samples of fixed setting, is only filled by rotating each sampling apparatus, reduces movement mechanism, increase the reliability of reaction tray component, and reduce the cost of reaction tray component.
Description
Technical field
The present invention relates to medical instrument field more particularly to a kind of reaction tray components, analysis instrument and its analysis side
Method.
Background technique
In the prior art, reaction tray component includes: to be incubated for disk and sample/reagent disc in Biochemical Analyzer, using sample
Sheet/reagent disc is turntable structure, and sample adding system is located at sample/reagent disc and is incubated for the outside of disk, to reliability and cost requirement
What is played a decisive role essentially consists in the quantity of movement mechanism.When carrying out entry analysis, sample/reagent disc contain it is a set of can
For driving sample/reagent rotation rotating mechanism to lead to internal sky simultaneously because including rotating mechanism in sample/reagent disc
Between it is occupied, probe can be only positioned at sample/reagent disc outside, and probe also includes rotating mechanism, and such situation undoubtedly both reduces
Global reliability, and increase cost.
Therefore, the existing technology needs to be improved and developed.
Summary of the invention
The technical problem to be solved in the present invention is that in view of the above drawbacks of the prior art, provide a kind of reaction tray component,
Analysis instrument and its analysis method, it is intended to solve the problems, such as that the global reliability of reaction tray component in the prior art is low, at high cost.
The technical proposal for solving the technical problem of the invention is as follows:
A kind of reaction tray component, comprising: be incubated for disk and several tray samples；It is provided on the incubation disk to be measured for carrying
Several the first containers of object, the rounded distribution of several the first containers, which is characterized in that set in each tray sample
Several second containers for carrying sample or reagent are equipped with, several described second containers are arc-shaped distribution；If described
It is round where dry second container that there is several first common points, each sample with circle where several described the first containers
Sampling apparatus is provided on disk, the sampling apparatus is rotated centered on the central axis of circle where several described second containers,
And by the second container sample or reagent fill into the first container on corresponding first common point；It is described several
At least one described second container is used to carry sample in a tray sample and at least one described second container is for carrying
Reagent.
The reaction tray component, wherein the sampling apparatus include: the first rotating shaft being arranged in the tray sample,
First probe and first connecting rod for connecting the first rotating shaft and first probe；The first rotating shaft is located at institute
State the center of circle where several second containers, first probe is used to draw sample in the second container or reagent simultaneously
Filling is into the first container.
The reaction tray component, wherein the sampling apparatus further include: second turn be set in outside the first rotating shaft
Axis, the second probe and the second connecting rod for connecting second shaft and second probe.
The reaction tray component, wherein be provided in the tray sample for carry sample or reagent several
Three containers；Several described third containers are arc-shaped distribution, the circle where several described third containers and it is described several
Circle where second container is concentric, round where described several the first containers to have the with circle where several described third containers
Two common points；Second probe be used for by the third container sample or reagent fill to corresponding second common point
In the first container.
The reaction tray component, wherein the tray sample upper surface is provided with refrigeration warehouse, and lower surface is provided with refrigeration dress
It sets；The refrigerating plant include: with the Peltier of the tray sample following table face contact, be arranged in the first of the Peltier surrounding
Heat-preservation cotton, the cooling fin that the Peltier bottom is set and the fan that the cooling fin side is set.
The reaction tray component, wherein it is described to be incubated for the thermostat being provided on disk for loading the first container,
It is provided with heating tape on the outside of the thermostat, is provided with the second heat-preservation cotton on the outside of the heating tape.
A kind of analysis instrument, wherein include: rack, the reaction as described in above-mentioned any one is provided in the rack
Disk component is arranged in the rack and is located at the evenly mixing device and cleaning device for being incubated for disc side；The mixing
Device is used to mix the determinand in the first container, and the cleaning device is for cleaning the first container.
The analysis instrument, wherein the evenly mixing device includes: the third shaft being arranged in the rack, stirring
Paddle and third connecting rod for connecting the third shaft and the agitating paddle；The agitating paddle is for stirring described first
Determinand in container, the third shaft is between the incubation disk and the sampling apparatus.
The analysis instrument, wherein the cleaning device includes: the mounting base and setting being arranged in the rack
Cleaning needle in the mounting base.
A kind of analysis method based on analysis instrument described in above-mentioned any one, wherein itself the following steps are included:
Cleaning device carries out the first container to react preceding cleaning；
Sampling apparatus is drawn the reagent in second container and is filled into the first container；
After the predetermined time, sampling apparatus, which is drawn the sample in second container and filled to first on the first common point, to be held
In device；
Evenly mixing device mixes determinand；
Cleaning device cleans after reacting the first container.
The utility model has the advantages that each tray sample fixed setting does not need since analyzer provided by the invention has several tray samples
Sample and reagent can be added in the first container being incubated on disk and be incubated for only by each sampling apparatus of rotation by rotation,
Reduce movement mechanism, increase the reliability of analyzer, and reduces the cost of analyzer.
Detailed description of the invention
Fig. 1 is the first structure diagram of reaction tray component in the present invention.
Fig. 2 is the second structural schematic diagram of reaction tray component in the present invention.
Fig. 3 is the third structural schematic diagram of reaction tray component in the present invention.
Fig. 4 is the 4th structural schematic diagram of reaction tray component in the present invention.
Fig. 5 is analysis instrument structural schematic diagram in the present invention.
Fig. 6 is the structural schematic diagram of tray sample and sampling apparatus in the present invention.
Fig. 7 is the structural schematic diagram that disk and the first rotating device are incubated in the present invention.
Fig. 8 is the explosive view of refrigerating plant in the present invention.
Fig. 9 is the structural schematic diagram of the second rotating device and third rotating device in the present invention.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer and more explicit, right as follows in conjunction with drawings and embodiments
The present invention is further described.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and do not have to
It is of the invention in limiting.
Please refer to Fig. 1-Fig. 9, the present invention provides described in a kind of some embodiments of reaction tray component.The application
Term " sample " used, any sample such as the body fluid analyzed in sample container and blood, type packet can be placed in by referring to
Include but be not limited to: material (including collecting biomaterial on swab such as throat, vagina, in cartilage, rectum, urethra, nose or nose
Throat swab), fluid, urine, blood, saliva, serum, blood plasma, fecal material, air-breathing, washing lotion, tissue homogenate and treatment fluid etc.；
Term " reagent " used herein refers to the object needed for being directed to sample and test item for reacting with sample
Matter, feature are not limited to: ingredient, form, composition, content etc..
As shown in Figure 1 and Figure 5, the present invention provides a kind of reaction tray components, comprising: is incubated for disk 1 and several samples
Disk 2；Several the first containers 11, several described rounded distributions of the first container 11, Mei Gesuo are provided on the incubation disk 1
Several second containers being provided in tray sample 2 for carrying sample or reagent are stated, the quantity of second container can be according to need
It is arranged.
Several second containers (being denoted as sample container 22) of carrying sample are arranged together, carry reagent several the
Two containers (being denoted as reagent container 21) are also arranged together, and to distinguish, sample container 22 and reagent container 21 can be using not
Similar shape, further progress are distinguished.Can sample container 22(be only set in tray sample 2 and is denoted as sample disk), can also only it be arranged
Reagent container 21(is denoted as reagent disc), can also sample container 22 be not only set but also setting reagent container 21(is denoted as sample/reagent
Disk).
Several described second containers are arc-shaped distribution, and specifically, arc-shaped can be major arc shape, or minor arc
Shape, certainly, sample container 22 and reagent container 21 are located on the same circle, i.e., circle where sample container 22 and reagent container 21 is same
One circle (is denoted as the second circle).Circle where several described the first containers 11 (being denoted as the first circle) and several described second container institutes
There is the first common point in circle, i.e., the first circle and the second circle are tangent or intersect, the first circle and second it is round tangent when with one the
One common point, tool is there are two the first common point when intersection, when the first circle and the second circle tool are there are two when the first common point, sampling cartridge
Sample or reagent can be filled into the first container on wherein one or two first common point by setting.Certain circular arc, which has, to be lacked
Mouthful, the first circle is opposite with the notch of circular arc.
Sampling apparatus 3 is provided in each tray sample 2, the sampling apparatus 3 is with several described second container institutes
Rotated centered on round central axis, and by the second container sample or reagent fill to first common point
In the first container 11.Sampling apparatus 3 is located in the second circle, can only be realized described in absorption by the rotation of sampling apparatus 3
Reagent or sample in second container, while sampling apparatus 3 can also turn to the first common point, and sample or reagent are filled
To in the first container 11 of the first common point.
There are several tray samples 2 in the reaction tray component, that is, there are several the second circles, each second circle is round with first
Have the first common point, and between each second circle mutually from.Corresponding sampling apparatus 3 is provided in each tray sample 2, for filling each sample
The reagent or sample in second container on disk 2.Certainly, being incubated for disk 1 can also be fixedly installed, and do not rotate, be provided with enough
Tray sample 2 when, only place the first container 11 at first round the first common point with each second circle, at this time the first common point base
Originally it is covered with the first circle, is incubated for disk 1 without rotating, movement mechanism can be further reduced, increase the reliability of reaction tray component, and drop
The cost of low reaction disk component.Certainly, being incubated for disk 1 may be set to be rotation, and being incubated for disk 1 by rotation can hold to each first
Device 11 is filled, and in addition to the first container 11 is arranged in the first common point, the first container 11 is also can be set in not common point, by turning
The dynamic disk 1 that is incubated for fills all the first containers 11.
When tray sample 2 only has one, it was both provided with sample container 22 and reagent container 21 in tray sample 2, tray sample 2 is set
It sets when being incubated for the side of disk 1, can be any position all around.When tray sample 2 has multiple (>=2), Ke Yifen
For sample disk and reagent disc.When the side for being incubated for disk 1 is arranged in multiple tray samples 2, any position all around can be.It is excellent
Selection of land, when tray sample 2 is 2,2 tray samples 2 are adjacent or opposite, and 2 tray samples 2 are adjacent to refer to that 2 tray samples 2 are mutually leaned on
Hold together, the opposite center for referring to 2 tray samples 2 of 2 tray samples 2 is located on the same line with the center for being incubated for disk 1.Work as tray sample
2 be 3 when, wherein 2 tray samples 2 are adjacent, the center of another 1 tray sample 2 is located at the axis of symmetry of 2 adjacent tray samples 2
On.
In several described tray samples 2 at least one described second container for carry sample and at least one described in
Second container is for carrying reagent.The reaction tray component is used to after mixing reagent and sample be incubated for, therefore is at least arranged
There are a sample container 22 and at least one reagent container 21.If the tray sample 2 is sample only with 1 tray sample 2
Sheet/reagent disc；If being respectively sample disk, reagent disc using 2 tray samples, 2,2 tray samples 2；If using 3 and 3
The above tray sample 2, then 1 tray sample 2 is sample disk, remaining tray sample 2 is reagent disc.
It is worth noting that reaction tray component provided by the invention has several tray samples 2, each tray sample 2 is fixedly installed,
It does not need to rotate, only by rotating each sampling apparatus 3, sample and reagent can be added to the first container 11 being incubated on disk 1
In be incubated for, reduce movement mechanism, increase the reliability of reaction tray component, and reduce the cost of reaction tray component.
In a preferred embodiment of the present invention, as shown in figure 5, the sampling apparatus 3 includes: to be arranged in the sample
First rotating shaft 31, the first probe 32 on disk 2 and first for connecting the first rotating shaft 31 and first probe 32
Connecting rod 33；The center of circle, first probe 32 are used for where the first rotating shaft 31 is located at several described second containers
It draws the sample or reagent in the second container and fills into the first container 11, the first probe 32 is located on second container
Side.Sampling apparatus 3 can stretch in vertical direction and (go up and down), and specifically, can be the first probe 32 or first rotating shaft 31 has
Telescopic, it is preferable that be set as being easier to realize with Telescopic by first rotating shaft 31.In 3 telescopic process of sampling apparatus
In, the first probe 32 can be protruded into second container and be retracted after drawing reagent, it is of course also possible to which protruding into the first container 11 will
The reagent of absorption is filled into the first container 11.
In another preferred embodiment of the present invention, sampling apparatus 3 further include: be set in outside the first rotating shaft 31
Two shaft 34(are as shown in Figure 9), the second probe (not shown) and for connecting second shaft 34 and described second
Second connecting rod (not shown) of probe.
Second probe can be arranged using following three kinds of modes, one is: have two when the first circle intersects with the second circle
A first common point is respectively as follows: the first filling point 12 and the second filling point 13, and first probe 32 is in first filling point
12 filling, second probe are filled in second filling point 13.Two the first common points can be filled simultaneously, are improved and are added
Infuse speed.
The second is: several third container (not shown)s for carrying sample or reagent are provided in tray sample 2,
Several third containers are arc-shaped distribution, circle (being denoted as third circle) and several second containers where several third containers
The circle at place is concentric circles, and circle where several described the first containers 11 has second with circle where several described third containers
Common point；Third circle can be used in the second inner round side or outside, second probe by the sample or reagent in third container
It fills into the first container 11 on corresponding second common point.Filling speed is not only accelerated, but also there are two rows of appearances in tray sample 2
Device, second container and third container are a row, and third container is a row, increase the capacity that tray sample 2 accommodates reagent or sample.
The third is: the sample container that second container has the reagent container 21 for being only used for carrying reagent and is only used for carrying sample
22, the first probe 32 is used to fill the reagent in second container, then the first probe 32 is reagent probe, and the second probe is for filling
Sample in second container, then the second probe is sample probe.When filling identical reagent or identical sample, it may not be necessary to right
Probe is cleaned, and can accelerate to fill speed.
In one particular embodiment of the present invention, as shown in fig. 7, the reaction tray component further include: incubated with described
Disk 1 is educated to connect and for rotating first rotating device for being incubated for disk 1.First rotating device includes: driven shaft 17,
One motor 14, the first driving wheel 15 being connect with the first motor 14 and engaged with first driving wheel 15 first from
Driving wheel 16, described 17 one end of driven shaft are connect with the incubation disk 1, and the other end is connect with first driven wheel 16.Pass through
The rotation of one motor 14, driving are incubated for disk 1 and rotate.First motor 14 uses stepper motor, convenient for stopping the first container 11 accurately
In predetermined position, convenient for operations such as filling, cleaning, detections.
In one particular embodiment of the present invention, please referring also to 5, Fig. 6 and Fig. 9 are provided in the tray sample 2
Two rotating devices and third rotating device, second rotating device connect with the first rotating shaft 31 and for rotating described the
One shaft 31, the third rotating device connect with second shaft 34 and for rotating second shaft 34.
The second driving wheel 36 that second rotating device includes: the second motor 35, is connect with second motor 35；Institute
The bottom end for stating first rotating shaft 31 protrudes from second shaft 34, and be provided with engaged with second driving wheel 36 second from
Driving wheel 37；The third driving wheel 39 that the third rotating device includes: third motor 38, is connect with the third motor 38；Institute
The bottom end for stating the second shaft 34 is provided with the third driven wheel 40 engaged with the third driving wheel 39.
In one particular embodiment of the present invention, as shown in figure 8,2 upper surface of the tray sample is provided with refrigeration warehouse 23.
Due to the particularity of reagent and sample, reaction tray component, which stores it, requires cold storage environment.Refrigeration warehouse 23 includes: the first side wall
231, second sidewall 232 and the connection wall 233 of connection the first side wall 231 and second sidewall 232.The first side wall 231, second side
Wall 232 is arc-shaped, and second container is between the first side wall 231 and second sidewall 232.The first side wall 231, second sidewall
232 bottom ends are connect with tray sample 2.Third heat-preservation cotton (not shown), specifically, the first side wall are provided on the outside of refrigeration warehouse 23
231, second sidewall 232, be provided with third heat-preservation cotton on the outside of connection wall 233.
2 lower surface of tray sample is provided with refrigerating plant 24, and specifically, there are two refrigerating plants 24, is symmetricly set on
2 lower surface of tray sample.The refrigerating plant 24 includes: the Peltier 241 that 2 lower surface of tray sample is arranged in, is arranged in institute
The first heat-preservation cotton 242 of 241 surrounding of Peltier is stated, the cooling fin 243 of 241 bottom of Peltier is set and is arranged in institute
State the fan 244 of 243 side of cooling fin.First heat-preservation cotton 242 is provided with the first through hole being adapted to Peltier 241, Paar
Patch 241 is arranged in the first through hole, so that the first heat-preservation cotton 242 is arranged around Peltier 241.241 upper surface of Peltier with
2 following table face contact of tray sample, 241 lower surface of Peltier are contacted with cooling fin 243, and for rapid cooling, fan 244, which will be arranged, to be dissipated
The heat transfer of backing 243 is gone out.
Further, refrigerating plant 24 further include: screw 245 and the spring being set on screw 245 (do not show in figure
Out), the second through-hole (not shown) passed through for screw 245 is provided on cooling fin 243,2 lower surface of tray sample is provided with
The screw hole (not shown) cooperated with screw 245, spring one end are contacted with cooling fin 243, control bullet by tightening screw 245
The compressive state of spring is adjacent to 2 lower surface of tray sample to change Peltier 241 with changing spring to the pressure of cooling fin 243
Degree not only guarantees there is preferable heat dissipation effect, but also Peltier 241 is avoided to be subject to crushing.
Further, 2 lower surface of tray sample is additionally provided with shell 25, has in shell 25 and accommodates refrigerating plant 24
Cavity, be provided with air intake vent (not shown) and air outlet 251 on shell 25, form the channel of ventilation, the air outlet 251
It is opposite with fan 244.
In one particular embodiment of the present invention, as shown in fig. 7, being provided on the incubation disk 1 described for loading
The thermostat 18 of the first container 11 is provided with heating tape 19 on the outside of the thermostat 18, is provided on the outside of the heating tape 19
Two heat-preservation cottons 20.Since the temperature of reagent and sample in refrigeration warehouse 23 is lower, and the optimum temperature environment of biochemical reaction is substantially
It is consistent with human body temperature, after the lower reagent of temperature is added in reaction cup, it can react immediately with sample, it can not be short
Reach optimum response environment in time, consequently leads to the mutation of reflection curve or results abnormity, song can only be passed through in such cases
Line correction is repaired to solve, and there are certain risk and drawbacks.
By the way that thermostat 18 is arranged, the first container 11 is placed in thermostat 18, thermostat 18 includes: that setting is being incubated for disk
Annular bottom wall (not shown) on 1 is arranged in the third side wall 181 of inside bottom wall and the 4th side of bottom wall outer is arranged in
Wall 182, between third side wall 181 and the 4th side wall 182, heating tape 19 and the second heat-preservation cotton 20 are successively set the first container 11
It sets in 182 outside of the 4th side wall.The first heat-preservation cotton 242, the second heat-preservation cotton 20 and third heat-preservation cotton can use in the present invention
XPE heat-preservation cotton.
The present invention also provides a kind of preferred embodiments of analysis instrument:
As shown in figure 5, the present invention provides a kind of analysis instruments, comprising: rack is provided with as above-mentioned any one in the rack
Reaction tray component described in is arranged in the rack and is located at the evenly mixing device 4 for being incubated for disc side and cleaning
Device 5；The evenly mixing device 4 is used to mix the determinand in the first container 11, and the cleaning device 5 is described for cleaning
The first container 11.The evenly mixing device 4 includes: third shaft 41, agitating paddle 43 and for connecting 41 and of third shaft
The third connecting rod 42 of the agitating paddle 43；The agitating paddle 43 is used to stir the determinand in the first container 11.
Specifically, evenly mixing device 4 can stretch in vertical direction and (go up and down), specifically, can be agitating paddle 43 or third
Shaft 41 has Telescopic.In 4 telescopic process of evenly mixing device, agitating paddle 43 can protrude into the first container 11 to determinand into
Row stirring.Certainly, rotation third shaft 41 can make agitating paddle 43 be located at 11 top of the first container, it is also possible that agitating paddle
43 are located at except the first container 11, namely are located at and are incubated for except disk 1.It is operated convenient for the filling of sampling apparatus 3.
In one particular embodiment of the present invention, as shown in figure 5, the third shaft 41 be located at the incubations disk 1 and
Between the sampling apparatus 3.Evenly mixing device 4 is located at the indentation, there of circular arc, preferably, third shaft 41 is located at and is incubated for disk 1 and adopts
Between sampling device 3, prevent from interfering between evenly mixing device 4 and sampling apparatus 3.
In one particular embodiment of the present invention, as shown in figure 5, the cleaning device 5 includes: mounting base 51 and sets
Set the cleaning needle 52 in the mounting base 51.Cleaning needle 52 is used for the first container 11 is cleaned before sample-adding or after reaction,
The blank of the first container 11 can also be tested to judge the state (dirty cup alarm) of the first container 11.Cleaning needle 52 has several,
Several the first containers 11 are respectively corresponded, cleaning needle 52 typically at least there are 2.
The analysis instrument further include: the liquid channel system in fixing seat 61 is arranged in fixing seat 61, and liquid channel system includes
Liquid storage tank 62, cleaning agent box 64, service sink 63 and waste liquid pool (not shown), liquid channel system and the first probe 32 and second are visited
Needle connection, for control the imbibition of the first probe 32 and the second probe/spit liquid measure, specifically, liquid storage tank 62 passes through pipeline and the
One probe 32 is connected with the second probe；Liquid channel system is connect with cleaning needle 52, for cleaning to the first container 11, specifically
Ground, liquid storage tank 62 are connect by pipeline with cleaning needle 52；Service sink 63 is used for the first probe 32, the second probe and agitating paddle
43 are cleaned, and waste liquid pool is for storing waste liquid.There are two service sinks 63, and two service sinks 63 are symmetricly set on indentation, there, often
There are two openings for a tool of service sink 63, are inserted into respectively for the first probe 32 and stirring rod, if being provided with the second probe certainly,
There are three openings for each tool of service sink 63.Cleaning agent need to be added to the first time cleaning of the first container 11, cleaning agent is contained in clearly
In lotion box 64.
The analysis instrument further include: be located at the 1 side photoelectric detection system 7 of incubations disk, be used for determinand into
Row absorbance detection is incubated for disk 1 and often rotates a circle, and each the first container 11 acquires an absorbance value.
The present invention also provides a kind of the preferable of analysis method based on analysis instrument described in above-mentioned any one embodiment
Embodiment:
A kind of analysis method based on analysis instrument described in above-mentioned any one embodiment described in the embodiment of the present invention, including it is following
Step:
Step S100, cleaning device 5 carries out the first container to react preceding cleaning.
Specifically, the quantity of cleaning needle 52 be X(X >=2) root, preferably, the quantity of cleaning needle 52 be 4, then can carry out 4
Rank cleaning.
Step S200, sampling apparatus 3 is drawn the reagent in second container and is filled into the first container.
Specifically, starting sampling apparatus 3 carries out reagent filling operation, and when original state, the first probe 32 is located at service sink
In 63, lifting the first probe 32 makes the first probe 32 be detached from service sink 63, and rotating first rotating shaft 31 is displaced the first probe 32
To the first predetermined position, first predetermined position is opposite with the second container of reagent to be drawn；Falling the first probe 32 makes first
Probe 32 protrudes into second container, and draws the reagent of the first predetermined amount；After having drawn, lifting the first probe 32 makes the first spy
Needle 32 takes off second container, and rotating first rotating shaft 31 makes the first probe 32 be moved to the first common point；Falling the first probe 32 makes
First probe 32 protrudes into the first container, and fills the reagent of the first predetermined amount；After having filled, lifting the first probe 32 makes
One probe 32 takes off the first container, and rotating first rotating shaft 31 makes the first probe 32 be moved to service sink 63, falls the first probe 32
It protrudes into the first probe 32 in service sink 63, completes reagent filling operation.
Step S300, after the predetermined time, sampling apparatus 3 is drawn the sample in second container and is filled to the first public affairs
In the first container on concurrent.
Specifically, when incubation disk 1 is set as not rotating, after the predetermined time, sampling apparatus 3 is drawn in second container
Sample and fill into the first container on the first common point, the predetermined time be specially react before pre-temperature time.
When incubation disk 1 is set as rotation, after the predetermined time, sampling apparatus 3 draws the sample in second container simultaneously
Filling is into the first container on the first common point, and the predetermined time here can be set as needed, and the time is specially anti-
The time of pre-temperature before answering.
Specifically, after the predetermined time, the first container for filling reagent before is moved to the first common point again, opens
Dynamic sampling apparatus 3 carries out sample filling operation, and when original state, the first probe 32 is located in service sink 63, lifts the first probe
32 make the first probe 32 be detached from service sink 63, and rotating first rotating shaft 31 makes the first probe 32 be moved to the second predetermined position, should
Second predetermined position is opposite with the second container of sample to be drawn；Falling the first probe 32 makes the first probe 32 protrude into second container
In, and draw the sample of the second predetermined amount；After having drawn, lifting the first probe 32 makes the first probe 32 take off second container, and
Rotation first rotating shaft 31 makes the first probe 32 be moved to the first common point；Falling the first probe 32 makes the first probe 32 protrude into first
In container, and fill the sample of the second predetermined amount；After having filled, lifting the first probe 32 holds the first probe 32 de- first
Device, and rotating first rotating shaft 31 makes the first probe 32 be moved to service sink 63, falling the first probe 32 protrudes into the first probe 32
In service sink 63, sample filling operation is completed.
It further include that step S400, evenly mixing device 4 mix determinand after step S300.
Specifically, determinand here includes the reagent and sample of filling.Starting evenly mixing device 4 mixes determinand
Operation, when original state, agitating paddle 43 is located in service sink 63, and lifting agitating paddle 43 makes the disengaging service sink 63 of agitating paddle 43, and
Rotating the second shaft 34 makes agitating paddle 43 be moved to the first common point；Falling agitating paddle 43 makes agitating paddle 43 protrude into the first container
In, and determinand is stirred；After having stirred, lifting agitating paddle 43 makes agitating paddle 43 take off the first container, and rotates second turn
Axis 34 makes agitating paddle 43 be moved to service sink 63, and falling agitating paddle 43 protrudes into agitating paddle 43 in service sink 63, completes stirring behaviour
Make.
Step S400 specifically further includes that step S410, sampling apparatus 3 are drawn another reagent in another second container and added
Note is mixed into the first container, and through evenly mixing device 4.
Specifically, it usually needs there are many reagents of addition, needed after carrying out step S200 and having filled a kind of reagent plus
Other reagents are infused, reagent filling operation can be carried out again by sampling apparatus 3, referring in particular to step S200, then by mixed
Even device 4 is mixed, referring in particular to step S400.
It further include that step S500, cleaning device 5 clean after reacting the first container after step S400.
Each reagent adds, and after having reacted, carries out corresponding Photoelectric Detection.After the completion of corresponding Photoelectric Detection, to first
Container is cleaned, referring in particular to step S100.
In conclusion a kind of reaction tray component, analysis instrument and its analysis method provided by the present invention, the reaction
Disk component includes: to be incubated for disk and several tray samples；Be provided on the incubation disk for carry determinand several
One container, the rounded distribution of several the first containers, wherein several second containers being arranged in each tray sample
It is arc-shaped distribution；It is round public with first with circle where several described the first containers where several described second containers
Point, is provided with sampling apparatus in each tray sample, and the sampling apparatus is with where several described second containers in circle
Rotated centered on mandrel, and by the second container sample or reagent fill to described first on corresponding first common point
In container.Due to several tray samples of fixed setting, is only filled by rotating each sampling apparatus, reduce fitness machine
Structure, increases the reliability of reaction tray component, and reduces the cost of reaction tray component, and is suitable for more Reagent Projects.
It should be understood that the application of the present invention is not limited to the above for those of ordinary skills can
With improvement or transformation based on the above description, all these modifications and variations all should belong to the guarantor of appended claims of the present invention
Protect range.
Claims (10)
1. a kind of reaction tray component, comprising: be incubated for disk and several tray samples；Be provided on the incubation disk for carry to
Survey several the first containers of object, the rounded distribution of several the first containers, which is characterized in that in each tray sample
Several second containers for carrying sample or reagent are provided with, several described second containers are arc-shaped distribution；It is described
It is round where several second containers that there is several first common points, each examination with circle where several described the first containers
Sampling apparatus is provided in sample dish, the sampling apparatus is turned centered on the central axis of circle where several described second containers
It is dynamic, and by the second container sample or reagent fill into the first container on corresponding first common point；It is described
At least one described second container is used to carry sample in several tray samples and at least one described second container is used for
Carry reagent.
2. reaction tray component according to claim 1, which is characterized in that the sampling apparatus includes: to be arranged in the examination
First rotating shaft, the first probe in sample dish and the first connecting rod for connecting the first rotating shaft and first probe；
The center of circle where the first rotating shaft is located at several described second containers, first probe hold for drawing described second
Sample or reagent and filling in device is into the first container.
3. reaction tray component according to claim 2, which is characterized in that the sampling apparatus further include: be set in described
The second shaft, the second probe outside first rotating shaft and the second connection for connecting second shaft and second probe
Bar.
4. reaction tray component according to claim 3, which is characterized in that be provided in the tray sample for carrying sample
Or several third containers of reagent；Several described third containers are arc-shaped distribution, several described third containers places
Circle and the circle where several described second containers it is concentric, it is round with several described thirds where described several the first containers
Circle has the second common point where container；Second probe be used for by the third container sample or reagent fill to right
It answers in the first container on the second common point.
5. reaction tray component according to claim 1, which is characterized in that the tray sample upper surface is provided with refrigeration warehouse,
Lower surface is provided with refrigerating plant；The refrigerating plant includes: with the Peltier of the tray sample following table face contact, setting in institute
The first heat-preservation cotton of Peltier surrounding is stated, the cooling fin of the Peltier bottom is set and is arranged in the cooling fin side
Fan.
6. reaction tray component according to claim 1, which is characterized in that be provided on the incubation disk described for loading
The thermostat of the first container, the thermostat outside are provided with heating tape, are provided with the second heat-preservation cotton on the outside of the heating tape.
7. a kind of analysis instrument characterized by comprising rack is arranged just like claim 1-6 any one in the rack
The reaction tray component, be arranged in it is in the rack and be located at it is described be incubated for the evenly mixing device of disc side, cleaning device with
And photoelectric detection system；The evenly mixing device is used to mix the determinand in the first container, and the cleaning device is for clear
The first container is washed, the photoelectric detection system is used to carry out absorbance detection to determinand.
8. analysis instrument according to claim 7, which is characterized in that the evenly mixing device includes: to be arranged in the rack
On third shaft, agitating paddle and the third connecting rod for connecting the third shaft and the agitating paddle；The stirring
Paddle is used to stir determinand in the first container, the third shaft be located at the incubation disk and the sampling apparatus it
Between.
9. analysis instrument according to claim 7, which is characterized in that the cleaning device includes: to be arranged in the rack
On mounting base and the cleaning needle that is arranged in the mounting base.
10. a kind of analysis method based on analysis instrument described in claim 7-9 any one, which is characterized in that it includes
Following steps:
Cleaning device carries out the first container to react preceding cleaning；
Sampling apparatus is drawn the reagent in second container and is filled into the first container；
After the predetermined time, sampling apparatus, which is drawn the sample in second container and filled to first on the first common point, to be held
In device；
Evenly mixing device mixes determinand；
Cleaning device cleans after reacting the first container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811110299.0A CN109142769A (en) | 2018-09-21 | 2018-09-21 | A kind of reaction tray component, analysis instrument and its analysis method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811110299.0A CN109142769A (en) | 2018-09-21 | 2018-09-21 | A kind of reaction tray component, analysis instrument and its analysis method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109142769A true CN109142769A (en) | 2019-01-04 |
Family
ID=64823569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811110299.0A Pending CN109142769A (en) | 2018-09-21 | 2018-09-21 | A kind of reaction tray component, analysis instrument and its analysis method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109142769A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6365370A (en) * | 1986-09-05 | 1988-03-23 | Nippon Tectron Co Ltd | Sample pipetting device |
| US5183638A (en) * | 1989-12-04 | 1993-02-02 | Kabushiki Kaisha Nittec | Automatic immunity analysis apparatus with magnetic particle separation |
| CN102192993A (en) * | 2010-03-12 | 2011-09-21 | 希森美康株式会社 | Sample analyzer |
| CN103499701A (en) * | 2013-09-04 | 2014-01-08 | 深圳市锦瑞电子有限公司 | Specific protein analyzer and analysis method thereof |
| CN104062448A (en) * | 2014-06-23 | 2014-09-24 | 珠海森龙生物科技有限公司 | Miniature biochemical analyzer |
| CN106133499A (en) * | 2014-04-22 | 2016-11-16 | 株式会社岛津制作所 | Heat homoiothermic specimen holder and use the specimen temperature adjusting means of this heating homoiothermic specimen holder |
| CN108169500A (en) * | 2017-11-24 | 2018-06-15 | 深圳市新产业生物医学工程股份有限公司 | Temperature control method and system |
-
2018
- 2018-09-21 CN CN201811110299.0A patent/CN109142769A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6365370A (en) * | 1986-09-05 | 1988-03-23 | Nippon Tectron Co Ltd | Sample pipetting device |
| US5183638A (en) * | 1989-12-04 | 1993-02-02 | Kabushiki Kaisha Nittec | Automatic immunity analysis apparatus with magnetic particle separation |
| CN102192993A (en) * | 2010-03-12 | 2011-09-21 | 希森美康株式会社 | Sample analyzer |
| CN103499701A (en) * | 2013-09-04 | 2014-01-08 | 深圳市锦瑞电子有限公司 | Specific protein analyzer and analysis method thereof |
| CN106133499A (en) * | 2014-04-22 | 2016-11-16 | 株式会社岛津制作所 | Heat homoiothermic specimen holder and use the specimen temperature adjusting means of this heating homoiothermic specimen holder |
| CN104062448A (en) * | 2014-06-23 | 2014-09-24 | 珠海森龙生物科技有限公司 | Miniature biochemical analyzer |
| CN108169500A (en) * | 2017-11-24 | 2018-06-15 | 深圳市新产业生物医学工程股份有限公司 | Temperature control method and system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3572815B1 (en) | Automatic analysis device and sample analysis method | |
| EP1007972B1 (en) | Automatic chemistry analyzer | |
| US5434083A (en) | Method and apparatus for automatically analyzing a plurality of test items | |
| CN106918715B (en) | A kind of chemiluminescence diagnostic device and its system | |
| CN111551758A (en) | Automatic analyzer | |
| JP2004521739A (en) | Method and apparatus for mixing liquid samples using vortex action | |
| US7364698B2 (en) | Automatic analyzer | |
| CN104597266B (en) | Centrifugal-type detection platform and operating process thereof | |
| JP2007524081A (en) | A method to improve the performance of automated clinical analyzers by using modular reagent delivery means | |
| CN109142769A (en) | A kind of reaction tray component, analysis instrument and its analysis method | |
| CN202710385U (en) | Novel system device suitable for a few blood samples to automatically blend evenly | |
| JP3661605B2 (en) | Immunoassay apparatus and immunoassay method | |
| US5271899A (en) | Chemistry analyzer | |
| EP4060349A1 (en) | Automatic analysis device | |
| CN212236887U (en) | Animal remedy production is with joining in marriage liquid device | |
| CN203069606U (en) | Full-automatic stool occult blood analyzer | |
| CN107121558A (en) | It is a kind of to extend the biochemical analyser of the corkage reagent term of validity | |
| CN109507438A (en) | A kind of linear incubation slot and its automatic clinical chemistry analyzer | |
| JP2004251797A (en) | Automatic analyzer | |
| JP3162171B2 (en) | Stirrer for automatic chemical analyzer | |
| CN208780540U (en) | The multiple pathogen liquid-phase chip detection kit of alimentary canal | |
| CN209264738U (en) | A kind of clinical laboratory's sample storage reaction device | |
| CN101031656A (en) | Methods and kits for the detection of biotoxis and antibiotic residues | |
| CN108624490A (en) | A kind of active cooperation detection device and method thereof of thioredoxin reductase | |
| WO1997011375A1 (en) | Means and method for washing reaction vessels |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190104 |
|
| RJ01 | Rejection of invention patent application after publication |