CN109142763A - A kind of POCT detection device having auto-scaling and its implementation - Google Patents
A kind of POCT detection device having auto-scaling and its implementation Download PDFInfo
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- CN109142763A CN109142763A CN201810991583.7A CN201810991583A CN109142763A CN 109142763 A CN109142763 A CN 109142763A CN 201810991583 A CN201810991583 A CN 201810991583A CN 109142763 A CN109142763 A CN 109142763A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00693—Calibration
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Abstract
The invention discloses a kind of POCT detection devices for having auto-scaling, the POCT detection device includes detection system, standard calibration plate and reagent card to be checked, the detection system is located at the top of standard calibration plate, reagent card to be checked, and the standard calibration plate is located at the two sides of the reagent card to be checked；Additionally provide a kind of POCT detection device implementation method for having auto-scaling, comprising the following steps: prepare standard calibration plate；The equipment of detection system is calibrated；Obtain reagent card batch calibration curve；Reading reagent card batch calibration curve；Obtain final testing result.The accuracy of POCT equipment detection can be improved in a kind of POCT detection device having auto-scaling provided by the invention and its implementation.
Description
Technical field
The present invention relates to POCT detection device technical field, especially a kind of POCT detection for having auto-scaling is set
Standby and its implementation.
Background technique
In-vitro diagnosis detection device is that the medical institutions such as hospital are commonly used to that patient's sample is detected and tied
The tool of fruit interpretation；Its test item range includes multiple and different field such as biochemical, immune, blood coagulation, hematology, molecular diagnosis
And scope；POCT detection device, that is, real-time test has, have the characteristics that it is easy to carry, easy to operate, quick and convenient, increasingly by
More medical institutions use, especially medium and small medical institutions.
But compared with full-automatic testing equipment, POCT detection device is since the daily specimen amount of the medical institutions at place is small, sets
The standby reasons such as the ability of maintenance is relatively low, transportation cost is high, cause often to be difficult to regularly be set according to the requirement of laboratory room managing
The work such as standby charge and calibration, have that accuracy is uncontrolled so as to cause testing result.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of POCT detection devices for having auto-scaling.
The technical solution of the present invention is as follows: a kind of POCT detection device for having auto-scaling, the POCT detection device
Including detection system, standard calibration plate and reagent card to be checked, the detection system be located at standard calibration plate, reagent card to be checked it is upper
Side, the standard calibration plate are located at the two sides of the reagent card to be checked.
Preferably, the detection system includes LED light and CMOS camera.
Preferably, the standard calibration plate includes gray scale block graphics and standard color block figure.
Preferably, the grey blocks figure includes black color lump and white color lump, and the black color lump and white color lump divide
Not Wei Yu the standard color block figure two sides.
Preferably, the reagent card to be checked is equipped with reagent card two dimensional code.
A kind of POCT detection device implementation method having auto-scaling, includes the following steps,
S1: it prepares standard calibration plate: the pattern image of standard calibration plate is demarcated；
S2: the equipment calibration of detection system: detection system equipment is led to by reading the pattern image in standard calibration plate
It crosses the original difference read between data and the target value of each pattern image of computing system and forms equipment calibration curve, equipment calibration curve
It is loaded into detection system, to complete the equipment calibration of detection system；
S3: reagent card batch calibration curve is obtained: the same equipment completed for being calibrated reagent card in the factory
Same equipment calibration is carried out, the reagent card of each batch is demarcated using the equipment in factory by calibration, to obtain
Obtain reagent card batch calibration curve；
S4: reading reagent card batch calibration curve: reagent card be used to be reagent card to be checked, detection system when Samples detection
System reading reagent card batch calibration curve；
S5: final testing result: detection system loading equipemtn calibration simultaneously when treating check reagent card and being detected is obtained
Curve and reagent card batch calibration curve to successively complete equipment calibration and the calibration of test card batch, therefore can obtain
Final testing result.
Preferably, in the step S1 using Jing Guo measurement certification reflectivity, color analysis instrument is to standard calibration plate
It is demarcated, i.e., the target value of gray scale therein, color character figure is demarcated.
Preferably, reagent card is completed by using the calibration product with traceability and clear target value in the step S3
Calibration.
Compared with prior art, the invention has the following beneficial effects: provided by the invention a kind of with auto-scaling function
The POCT equipment and its implementation of energy；The equipment includes detection system, standard calibration plate and reagent card to be checked；Wherein, it detects
System carries out information collection to standard calibration plate and reagent card to be checked by the modes such as scanning, taking pictures, and is joined by using calibration
Number is calibrated and is calculated to obtain corresponding testing result and exported；Standard calibration plate is built in equipment, detection
System carries out detection to standard calibration plate and carries out auto-scaling according to detection data, will test by the setting of scaling parameter and is
The detection performance of system is calibrated to standard state when factory；Reagent card to be checked is the examination that sample is added according to reagent card test request
Agent card, reagent card to be checked have corresponding product difference between batch scaling parameter, this scaling parameter is passed through after carrying out reagent card production
The reagent card of the detection device and this batch that are similarly in standard state is calibrated, detection system is by automatic
After calibration calibration compensation directly can be carried out using difference between batch of the difference between batch parameter of reagent card to be checked to reagent card；Pass through detection
Equipment detection performance can be calibrated to standard state first by the difference between batch parameter of system, standard calibration plate and reagent card to be checked,
Then difference between batch is compensated to obtaining accurate detection end value, and avoid the need for calibrating by standard items
Complicated processes and great number cost.
Detailed description of the invention
Fig. 1 is 1 structural schematic diagram of the embodiment of the present invention.
Fig. 2 is 1 standard calibration plate schematic diagram of the embodiment of the present invention.
Fig. 3 is 2 structural schematic diagram of the embodiment of the present invention.
Fig. 4 is 2 standard calibration plate schematic diagram of the embodiment of the present invention.
Fig. 5 is the principle of the present invention flow chart
Specific embodiment
With reference to the accompanying drawing and specific embodiment, the present invention will be further described.
Embodiment 1
As shown in Fig. 1-Fig. 2 and Fig. 5, this POCT detection device is colloid gold test paper analyzer, wherein in detection system (1)
Portion provides illumination by LED light (12), using CMOS camera (11) by carrying out information collection by the way of taking pictures.
Standard calibration plate (2) is located at reagent card to be checked (3) two sides, is built in equipment.Standard calibration plate (2) passes through printing
Mode make, inside is comprising by black color lump (211) and white color lump (212) gray scale block graphics (21) for forming, black
The corresponding gray scale target value of figure of color lump (211) and white color lump (212) is by the reflective illumination photometer measurement by calibrating and pre-
It is first stored in detection system.
Test after detection system (1) can be switched on daily automatically according to the setting of equipment or every time preceding or test every time
When equipment is calibrated.When starting calibration, detection system lightening LED lamp (1) starts CMOS camera (11) to standard calibration
Plate (2) is taken pictures, and obtains the original gray value of black color lump (211) and white color lump (212) respectively.
Detection system (1) obtain black color lump (211) and white color lump (212) original gray value after with corresponding target value
It is compared calculating and obtains equipment Alignment curve.This calibration curve is saved and to all reagent card (3) to be checked by detection system
Testing result value carry out the calibration of this curve.
Reagent production plant also uses the above method to carry out equipment calibration, examination to the equipment for obtaining reagent calibration curve
Corresponding equipment calibration curve is loaded and is used for subsequent acquisition reagent card calibration curve by plant produced equipment when agent is stuck in production
Test process.
Reagent card by equipment Alignment plant produced equipment in using the calibration product with traceability and target value as sample,
Preparation of samples is carried out according to reagent card test request, sample-adding, pre-temperature, waits the work such as reaction completion and by ready wait inspect
Agent card (3) is put into equipment.
Detection system (1) starting of plant produced equipment is treated the detection of check reagent card (3) and is obtained corresponding by setting
The equipment reading of standby calibration curve calibration；It can be obtained correspondence by the test to different gradients, i.e., the calibration product of different target value
The calibration curve of reagent card.
Using this calibration curve as the general calibration curve of this batch reagent card, this calibration curve is generated into reagent card two dimension
Code (31) is simultaneously printed on this batch others reagent card.
Reagent card (3) to be checked completes preparation of samples, sample-adding, in advance according to reagent card test request in the equipment that user uses
Temperature waits the work such as reaction completion and ready reagent card (3) to be checked is put into equipment.The detection system (1) of equipment
It lights LED etc. (12) and carries out photo, starting CMOS camera (11) treats check reagent card (3) and takes pictures；Detection system (1) is first
It first obtains in reagent card to be checked (3) reagent two dimensional code (31) and to obtain the corresponding reagent of this reagent card (3) to be checked by decoding fixed
Mark curve；Detection system (1) obtains corresponding grey by treating the calculating of C line and T line image in check reagent card (3) again
According to, then pass through comparing calculation obtain test result original reading；Detection system (1) is first fixed according to equipment to this original reading
Mark curve carries out calibration calculating, then carries out test card calibration according still further to test card calibration curve and calculates, to obtain final survey
Test result.
Embodiment 2
As shown in Fig. 3 to Fig. 4 and Fig. 5, this POCT detection device is routine urinalysis test paper analyzer, wherein detection system (1)
Inside distinguishes adjustable LED light (12) by three colors and provides illumination, using CCD camera (11) by carrying out information by the way of taking pictures
Acquisition.
Standard calibration plate (2) is located at test strips to be checked (3) two sides, is built in equipment.Standard calibration plate (2) passes through printing
Mode make, inside includes the figure that is made of completely black, Quan Bai, Quan Hong, half red, Quan Lv, half green, Quan Lan, half blue block, respectively
The corresponding color target value of color lump is measured by the reflectance spectrophotomete by calibrating and is stored in advance in the detection system.
Test after detection system (1) can be switched on daily automatically according to the setting of equipment or every time preceding or test every time
When equipment is calibrated.When starting calibration, the RGB wick of three-color LED light is first lighted simultaneously, starts CCD camera to mark
Certainly mark version is taken pictures, and obtains the color-values of black and white color money respectively；System according to obtained color-values with it is corresponding
Target value is compared calculating to obtain the equilibrium relation of three colors, and makes the light emission luminance one of three-color LED by adjusting LED light
The white light that cause, i.e. this three-color LED will issue three kinds of color balances.
It is then detected that system lights the red wick in three-color LED light (1), starting CCD camera to standard calibration plate into
Row is taken pictures, and obtains full gray value red, half red block is in the case where red wick illuminates respectively.
It is then detected that system lights the green wick in three-color LED light (1), starting CCD camera to standard calibration plate into
Row is taken pictures, and obtains full gray value of green, half green block in the case where green wick illuminates respectively.
It is then detected that system lights the blue wick in three-color LED light (1), starting CCD camera to standard calibration plate into
Row is taken pictures, and obtains full gray value blue, half blue block is in the case where blue wick illuminates respectively.
Detection system (1) obtain variant color color lump after the original gray value under corresponding color LED light illuminates with it is right
The target value answered is compared calculating and obtains equipment Alignment curve.Detection system saves this calibration curve and to all wait inspect
The testing result value of paper slip (3) carries out the calibration of this curve.
Reagent production plant also uses the above method to carry out equipment calibration, examination to the equipment for obtaining reagent calibration curve
Corresponding equipment calibration curve is loaded and is used for subsequent acquisition test strips calibration curve by paper slip plant produced equipment in production
Test process.
Test strips by equipment Alignment plant produced equipment in using the calibration product with traceability and target value as sample,
Preparation of samples is carried out according to test strips test request, sample-adding, pre-temperature, waits the work such as reaction completion and by ready wait inspect
Paper slip (3) is put into equipment.
Detection system (1) starting of plant produced equipment is treated the detection for inspecting paper slip (3) and is obtained corresponding by setting
The equipment reading of standby calibration curve calibration；It can be obtained correspondence by the test to different gradients, i.e., the calibration product of different target value
The calibration curve of test strips.
Using this calibration curve as the general calibration curve of this batch test strips, this calibration curve is generated into test strips two dimension
Code (31) is simultaneously printed onto this batch others test strips.
Test strips (3) to be checked complete preparation of samples, sample-adding, in advance according to test strips test request in the equipment that user uses
Temperature waits the work such as reaction completion and ready test strips (3) to be checked is put into equipment.The detection system (1) of equipment
It lights three-color LED etc. (12) and carries out photo, starting CCD camera (11), which is treated, to be inspected paper slip (3) and take pictures；Detection system
(1) reagent two dimensional code (31) is obtained in test strips to be checked (3) first and the corresponding examination of this test strips (3) to be checked is obtained by decoding
Agent calibration curve；Detection system (1) obtains corresponding color data by treating to inspect paper slip (3) conversion zone and take pictures again, after
And the original reading of test result is obtained by comparing calculation；Detection system (1) first calibrates this original reading bent according to equipment
Line carries out calibration calculating, then carries out test card calibration according still further to test card calibration curve and calculates, to obtain final test knot
Fruit.
The above embodiments are merely a preferred embodiment of the present invention, and cannot limit interest field of the invention with this, because
This is still within the scope of the present invention according to modification, equivalent variations, improvement etc. made by scope of the present invention patent.
Claims (8)
1. a kind of POCT detection device for having auto-scaling, it is characterised in that: the POCT detection device includes detection system
System, standard calibration plate and reagent card to be checked, the detection system are located at the top of standard calibration plate, reagent card to be checked, the mark
The certainly target two sides that are located at the reagent card to be checked.
2. a kind of POCT detection device for having auto-scaling according to claim 1, it is characterised in that: the inspection
Examining system includes LED light and CMOS camera.
3. a kind of POCT detection device for having auto-scaling according to claim 1, it is characterised in that: the mark
Certainly target includes gray scale block graphics and standard color block figure.
4. a kind of POCT detection device for having auto-scaling according to claim 3, it is characterised in that: the ash
Degree block graphics includes black color lump and white color lump, and the black color lump and white color lump are located at the standard color block figure
Two sides.
5. a kind of POCT detection device for having auto-scaling according to claim 1, it is characterised in that: it is described to
Check reagent card is equipped with reagent card two dimensional code.
6. a kind of POCT detection device implementation method according to any one of claims 1 to 5 for having auto-scaling,
It is characterized by comprising following steps,
S1: it prepares standard calibration plate: the pattern image of standard calibration plate is demarcated；
S2: the equipment calibration of detection system: detection system equipment passes through meter by reading the pattern image in standard calibration plate
The original difference read between data and the target value of each pattern image of calculation system forms equipment calibration curve, the load of equipment calibration curve
To detection system, to complete the equipment calibration of detection system；
S3: obtain reagent card batch calibration curve: the same equipment completed for being calibrated reagent card carries out in the factory
Same equipment calibration, demarcates the reagent card of each batch using the equipment in factory by calibration, to be tried
Agent card batch calibration curve；
S4: reading reagent card batch calibration curve: reagent card be used to be reagent card to be checked when Samples detection, and detection system is read
Take reagent card batch calibration curve；
S5: obtain final testing result: detection system when treating check reagent card and being detected simultaneously loading equipemtn calibration curve
With reagent card batch calibration curve, to successively complete equipment calibration and the calibration of test card batch, therefore can obtain final
Test result.
7. a kind of POCT detection device implementation method for having auto-scaling according to claim 6, feature exist
In: pair standard calibration plate is demarcated using reflectivity, the color analysis instrument Jing Guo measurement certification in the step S1, i.e.,
Gray scale therein, the target value of color character figure are demarcated.
8. a kind of POCT detection device implementation method for having auto-scaling according to claim 6, feature exist
In: the calibration of reagent card is completed in the step S3 by using the calibration product with traceability and clear target value.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111912974A (en) * | 2019-05-09 | 2020-11-10 | 深圳市帝迈生物技术有限公司 | Immune reagent calibration method |
| CN114002423A (en) * | 2021-12-31 | 2022-02-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and detection method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101598661A (en) * | 2009-07-07 | 2009-12-09 | 上海铭源数康生物芯片有限公司 | The corrector strip and the preparation method that use in a kind of Urine Analyzer based on the test reflectivity |
| CN102636627A (en) * | 2012-03-19 | 2012-08-15 | 苏州生物医学工程技术研究所 | Inter-batch quality control method for external diagnostic reagent |
| CN102707051A (en) * | 2012-06-07 | 2012-10-03 | 中国科学院上海光学精密机械研究所 | Performance correction method for gold mark immunochromatographic test strip detection system |
| CN104101704A (en) * | 2014-07-02 | 2014-10-15 | 华中科技大学 | Method for quantitative detection of immunochromatographic test card |
| CN104964973A (en) * | 2015-07-08 | 2015-10-07 | 邓双胜 | Test paper reading and analyzing method and system based on mobile terminal camera |
| CN105973885A (en) * | 2016-05-27 | 2016-09-28 | 宋秀龙 | Color-discrimination-based rapid detection system and rapid dry chemistry detection method |
| CN106546581A (en) * | 2016-11-02 | 2017-03-29 | 长沙云知检信息科技有限公司 | Detection paper card intelligent checking system and detection paper card intelligent analysis method |
| CN206400542U (en) * | 2016-08-19 | 2017-08-11 | 柳州康云互联科技有限公司 | Simple high in the clouds medical treatment transducer |
-
2018
- 2018-08-29 CN CN201810991583.7A patent/CN109142763A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101598661A (en) * | 2009-07-07 | 2009-12-09 | 上海铭源数康生物芯片有限公司 | The corrector strip and the preparation method that use in a kind of Urine Analyzer based on the test reflectivity |
| CN102636627A (en) * | 2012-03-19 | 2012-08-15 | 苏州生物医学工程技术研究所 | Inter-batch quality control method for external diagnostic reagent |
| CN102707051A (en) * | 2012-06-07 | 2012-10-03 | 中国科学院上海光学精密机械研究所 | Performance correction method for gold mark immunochromatographic test strip detection system |
| CN104101704A (en) * | 2014-07-02 | 2014-10-15 | 华中科技大学 | Method for quantitative detection of immunochromatographic test card |
| CN104964973A (en) * | 2015-07-08 | 2015-10-07 | 邓双胜 | Test paper reading and analyzing method and system based on mobile terminal camera |
| CN105973885A (en) * | 2016-05-27 | 2016-09-28 | 宋秀龙 | Color-discrimination-based rapid detection system and rapid dry chemistry detection method |
| CN206400542U (en) * | 2016-08-19 | 2017-08-11 | 柳州康云互联科技有限公司 | Simple high in the clouds medical treatment transducer |
| CN106546581A (en) * | 2016-11-02 | 2017-03-29 | 长沙云知检信息科技有限公司 | Detection paper card intelligent checking system and detection paper card intelligent analysis method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111912974A (en) * | 2019-05-09 | 2020-11-10 | 深圳市帝迈生物技术有限公司 | Immune reagent calibration method |
| CN111912974B (en) * | 2019-05-09 | 2022-02-18 | 深圳市帝迈生物技术有限公司 | Immune reagent calibration method |
| CN114002423A (en) * | 2021-12-31 | 2022-02-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and detection method thereof |
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Application publication date: 20190104 |