CN109124809A - A kind of Neonatal Mouse heart infarction model puncture outfit - Google Patents
A kind of Neonatal Mouse heart infarction model puncture outfit Download PDFInfo
- Publication number
- CN109124809A CN109124809A CN201811094409.9A CN201811094409A CN109124809A CN 109124809 A CN109124809 A CN 109124809A CN 201811094409 A CN201811094409 A CN 201811094409A CN 109124809 A CN109124809 A CN 109124809A
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- Prior art keywords
- spring
- release
- connecting rod
- steel wire
- puncture
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention provides a kind of Neonatal Mouse heart infarction model puncture outfit and its sting device and application methods, further provide a kind of horse shoe clamp of special shape, one end of its handle that Neonatal Mouse heart infarction model puncture outfit is set, since other special shapes are bonded completely with myocardium curved surfaces, heart formation is outflanked, the possibility of heart double swerve, avoids and injures cardiac muscle when solving puncture；Further, puncture needle is passed through predetermined heart tissue using elastic potential energy by the spring in puncture outfit, can quickly complete puncturing operation, and the time is short, high-efficient, is accelerated the process of experiment, is shortened experimental period, improves operation survival rate.
Description
Technical field
The present invention relates to a kind of Neonatal Mouse heart infarction model puncture outfit more particularly to a kind of puncture dresses with puncture outfit
It sets, and a step includes the horse shoe clamp with special shape, belongs to medical instruments field.
Background technique
In medical research, for Neonatal Mouse since heart rate is fast, heart size is small, studies at present its heart infarction model less.?
It in the production of heart infarction model, is completed at present by manual operation, presently, there are two large problems: on the one hand, due to suckling mouse heart rate
Fastly, frequency per minute reaches 500-600 times, and quickly contraction, diastole dynamical state is presented, this makes experimenter in modelling,
It is easy to shake, causes puncture position to be not fixed, influence the ligation site of heart infarction model, cause the inaccuracy of experimental data.It is another
Aspect, due to suckling mouse heart rate it is fast, puncture Venipuncture time it is longer, extend operating time, increase the experimental subjects death rate.
Summary of the invention
The technical problem to be solved in the present invention is that having overcome the deficiencies of the prior art and provide a kind of Neonatal Mouse heart infarction mould
Type needle-threader.
In order to solve the above technical problems, the present invention adopts the following technical scheme:
A kind of puncture outfit of Neonatal Mouse heart infarction model, the puncture outfit include that middle part sets reeded component, left part
Emission system equipped with puncture needle, right part are equipped with the reception system of puncture needle；The inner surface of the groove is outer with suckling mouse heart
Surface fits.
Further, the emission system includes transmitting spring, push pin connecting rod and storage needle cavity, emits one end of spring and pushes away
One end of needle connecting rod is close to, and the other end for connecting rod of pushing pin protrudes into storage needle cavity, and after release emits spring, connecting rod of pushing pin, which will push, stores up needle
Intracavitary puncture needle projects outward.
Further, the reception system includes receiving cavity, upper reception connecting rod, lower reception connecting rod, upper spring, lower spring,
One end of upper spring is close to upper one end for receiving connecting rod, and the upper other end for receiving connecting rod is placed in receiving cavity, and the one of lower spring
It holds and is close to lower one end for receiving connecting rod, the lower other end for receiving connecting rod is placed in receiving cavity, discharges upper spring and lower spring point
Not Tui Dong on receive connecting rod and lower reception link motion, and then clamp the puncture needle projected in storage needle cavity.
Further, including liftable operating stick, release transmitting spring steel wire, pulling back emits spring steel wire, release transmitting bullet
Spring handle, pulling back emits snapholder, and release reception spring steel wire, pulling back receives spring steel wire, and release receives snapholder, reception of pulling back
Snapholder；Wherein one end of the release transmitting spring steel wire passes through liftable operating stick and connect with transmitting spring, the release
The other end for emitting spring steel wire is connect with release transmitting snapholder, and described one end for emitting spring steel wire of pulling back is across liftable
Operating stick is connect with transmitting spring, and described pull back emits the other end of spring steel wire and emit snapholder and connect with pulling back.
Further, one end that the release receives spring steel wire passes through liftable operating stick and upper spring and lower spring connects
It connects, the release receives the other end of spring steel wire and release receives snapholder and connect, and described pull back receives the one of spring steel wire
End is connect across liftable operating stick with upper spring and lower spring, and described pull back receives the other end of spring steel wire and reception of pulling back
Snapholder connection.
Further, including ligature and line room is deposited, the ligature, which is placed in, to be deposited in line room, and one end is connect with puncture needle.
Another aspect of the present invention provides a kind of sting device including above-mentioned puncture outfit, further comprises having handle,
Liftable operating stick is set to the point of intersection of the handle；
Horse shoe clamp is made of left horse shoe clamp and right horse shoe clamp, is respectively arranged at one end of handle, is wrapped for being formed to heart
It copies.
Further, left horse shoe clamp is identical with right ungulate clamping structure, is made of similar ellipse and similar trapezoidal steel wire,
It is characterized in that, the entire loop-drive of similar ellipse is in a shape, the length of the similar trapezoidal middle line and the similar ellipse
Axis is vertical and passes through the central point of similar ellipse；The similar trapezoidal upper bottom is left a blank, both ends respectively with like ellipse with
Arc transition mode connect；The similar trapezoidal bottom is left a blank, and is connected respectively with the both ends of other devices；It is described similar
The trapezoidal spill that faces down is at a cambered surface.
Further, left horse shoe clamp and right horse shoe clamp have steel wire to be made.
Further, the cambered surface be arc length caused by using 60 ° of central angles, radius 1.4cm as standard for 1.466cm arc
Face.
Further, the long axis of the similar ellipse is about 1cm, and short axle is about 0.8cm；The similar trapezoidal upper bottom is about
For 0.4cm, bottom is about 0.8cm, and height is about 1.2cm.
Another aspect of the present invention provides the application method of above-mentioned sting device, includes the following steps: operation handle,
Make to enter from oblique cutting at left and right sides of heart respectively from left horse shoe clamp and the right side are ungulate, heart formation be outflanked, heart when solving puncture
The possibility of double swerve.
Further, liftable operating stick is reduced, is close to the inner surface of the groove of puncture outfit with the outside of heart, ensure that
The possibility that heart fluctuates up and down.
Further, lifting release transmitting snapholder, transmitting elastic potential energy of the spring release, moment push pin connecting rod, push pin
Kinetic energy is transferred to puncture needle by connecting rod, and puncture needle, which obtains after kinetic energy passes through predetermined heart tissue, enters receiving cavity.
Further, lifting release receives snapholder, upper spring and lower spring abrupt release, push receive connecting rod and
Lower reception link motion, and then clamp the puncture needle projected in storage needle cavity.
Further, liftable operating stick is risen, pulls back and receives snapholder, takes out the puncture needle with ligature, is carried out next
Step ligation.
Beneficial effects of the present invention:
A kind of horse shoe clamp of special shape of the present invention, is arranged in the one of the handle of Neonatal Mouse heart infarction model puncture outfit
End is outflanked heart formation, heart is left when solving puncture since other special shapes are bonded completely with myocardium curved surfaces
The possibility of right shaking, avoids and injures cardiac muscle, it is ensured that the puncture position of every suckling mouse is fixed, and ensure that the one of data
Cause property, accuracy；Further, puncture needle is passed through predetermined heart tissue using elastic potential energy by the spring in puncture outfit, can be quick
Puncturing operation is completed on ground, and for entire puncture process less than 2 seconds, the time was short, high-efficient, is accelerated the process of experiment, is shortened experiment
Time improves operation survival rate.
Detailed description of the invention
Fig. 1 is the total schematic diagram of sting device of the invention；
Fig. 2 is the structural schematic diagram of puncture outfit of the invention；
Fig. 3 is the structural schematic diagram of horse shoe clamp of the invention.
Fig. 4 is the structural schematic diagram of the reception system of puncture needle of the invention.
Fig. 5 is the structural schematic diagram of the emission system of puncture needle of the invention.
Fig. 6 is the structural schematic diagram of liftable operating stick of the invention.
Specific embodiment
Below in conjunction with attached drawing, the present invention is described in detail.It should be noted that these attached drawings and verbal description are not
The conception range for being intended to limit the invention in any way, but be by referring to specific embodiments those skilled in the art's explanation
Idea of the invention.
In conjunction with attached drawing 1-6, in the present invention, a kind of puncture outfit 1 of Neonatal Mouse heart infarction model, the puncture outfit packet are provided
The component 2 that middle part is equipped with groove 2-1 is included, left part is equipped with the emission system 3 of puncture needle 6, and right part is equipped with the reception system of puncture needle
System 4；The outer surface of the inner surface and suckling mouse heart 5 of the groove 2-1 fits.
In conjunction with Fig. 5, the emission system 3 includes transmitting spring 3-1, push pin connecting rod 3-2 and storage needle cavity 3-3, emits bullet
One end of spring 3-1 is close to the one end for the connecting rod 3-2 that pushes pin, and the other end for the connecting rod 3-2 that pushes pin protrudes into storage needle cavity 3-3, release transmitting
After spring 3-1, connecting rod of pushing pin will push the puncture needle 6 in storage needle cavity 3-3 to project outward.There is release spring card in emission system 3
3-4 a pair is detained, the nearly needle end two sides of transmitting spring 3-1, end Connection Release spring steel wire are stuck in；It buckles 3-4 and leans on short round
Spring side is connected with triangular supports 3-5, and Return spring buckles 3-6 and is connected with spring steel wire is received；.
In conjunction with Fig. 4, the reception system 4 includes receiving cavity 4-1, upper reception connecting rod 4-2, lower reception connecting rod 4-3, upper bullet
Spring 4-4, lower spring 4-5, one end of upper spring 4-4 is close to upper one end for receiving connecting rod 4-2, upper to receive the another of connecting rod 4-2
End is placed in receiving cavity 4-1, and one end of lower spring 4-5 is close to lower one end for receiving connecting rod 4-3, lower to receive the another of connecting rod 4-3
One end is placed in receiving cavity 4-1, and release upper spring 4-4 and lower spring 4-5 is pushed respectively receives connecting rod 4-2 and lower reception connecting rod
4-3 movement, and then clamp the puncture needle 6 projected in storage needle cavity.There is release spring buckle 4-9 two right in reception system 4,
Return spring buckles 4-8；Furthermore pull back discharge steel wire in each turning point the steering-effecting by several fixed pulley 4-7
Further, in conjunction with Fig. 1-5, including liftable operating stick 7, release transmitting spring steel wire 7-1, pulling back emits spring steel
Silk 7-2, release transmitting snapholder 7-3, pulling back emits snapholder 7-4, and release reception spring steel wire 7-5, pulling back receives spring steel
Silk 7-6, release reception snapholder 7-7, pulling back receives snapholder 7-8；Wherein one end of the release transmitting spring steel wire 7-1 is worn
It crosses liftable operating stick 7 to connect with transmitting spring, the other end and release transmitting snapholder 7-3 of the release transmitting spring steel wire
Connection, it is described pull back emit spring steel wire 7-2 one end pass through liftable operating stick 7 with emit spring 3-1 connect, it is described to pull back
Emit the other end of spring steel wire 7-2 and emits snapholder 7-4 and connect with pulling back.
Further, in conjunction with Fig. 1-5, one end that the release receives spring steel wire 7-5 passes through liftable operating stick 7 and upper bullet
Spring 4-4 is connected with lower spring 4-5, and the release receives the other end of spring steel wire 7-5 and release receives snapholder 7-7 and connect,
It is described pull back receive spring steel wire 7-6 one end pass through liftable operating stick 7 connect with upper spring 4-4 and lower spring 4-5, it is described
It pulls back and receives the other end of spring steel wire 7-6 and receive snapholder 7-8 and connect with pulling back.
In conjunction with Fig. 6, liftable operating stick 7 passes perpendicularly through the axis 8-1 of operation handle 8, and liftable operating stick 7 has in side
0.2 × 0.4mm fixation hole 8-2, vertical arrangement are inserted into for L-type Caton one end connecting rod 8-3, are gone up and down to liftable operating stick 7
It is fixed.The long handle side of L-type Caton connecting rod passes through fixing axle, has among bottom surface and is connected with the spring 8-5 being fixed on axis,
It can play the role of Caton connecting rod 8-3 and be close to axis 8-1.There is lifting buckle 8-4 mono- in the side of liftable operating stick 7, just
In its lifting.
In conjunction with Fig. 1-5, including ligature 3-4 and line room 3-5 is deposited, the ligature 3-4, which is placed in, to be deposited in the 3-5 of line room, one
End is connect with puncture needle 6.
In conjunction with Fig. 1-5, another aspect of the present invention provides a kind of sting device Z including above-mentioned puncture outfit, further
It include handle 8, liftable operating stick 7 is set to the point of intersection of the handle 8；
Horse shoe clamp is made of left horse shoe clamp 8-1 and right horse shoe clamp 8-2, is respectively arranged at one end of handle, for heart
Formation is outflanked.
In conjunction with attached drawing 3, left horse shoe clamp 8-1 is identical with right horse shoe clamp 8-2 structure, by similar ellipse and similar to trapezoidal
Steel wire composition, which is characterized in that the entire loop-drive of similar ellipse in a shape, the similar trapezoidal middle line with it is described similar ellipse
Circular long axis is vertical and passes through the central point of similar ellipse；The similar trapezoidal upper bottom is left a blank, and both ends are respectively and seemingly
Ellipse by arc transition in a manner of connect；The similar trapezoidal bottom is left a blank, and is connected respectively with the both ends of other devices；
The similar trapezoidal spill that faces down has steel wire or special material to be made at the left horse shoe clamp of a cambered surface and right horse shoe clamp,
Such as high molecular material, other inorganic material etc..
In conjunction with attached drawing 3, the cambered surface is arc length caused by using 60 ° of central angle a, radius r 1.4cm as standard for 1.466cm
Cambered surface.
In conjunction with attached drawing 3, the major axis A of the similar ellipse is about 1cm, and short axle B is about 0.8cm；It is described similar trapezoidal
Upper bottom C is about 0.4cm, and bottom D is about 0.8cm, and high H is about 1.2cm.
Another aspect of the present invention provides the application method of above-mentioned sting device Z in conjunction with Fig. 1-6, including walks as follows
Rapid: operation handle 8 makes to enter from 5 left and right sides oblique cutting of heart respectively from left horse shoe clamp 8-1 and right ungulate 8-2, to the formation of heart 5
It outflanks, the possibility of 5 double swerve of heart when solving puncture.Liftable operating stick 7 is reduced, makes that the groove 2-1's of puncture outfit 1 is interior
Surface is close to the outside of heart, ensure that the possibility that about 5 heart fluctuates.Lifting release transmitting snapholder 7-3, emits spring
The release of 3-1 elastic potential energy, moment push pin connecting rod 3-2, and kinetic energy is transferred to puncture needle 6 by the connecting rod 3-2 that pushes pin, and puncture needle 6 obtains
It obtains after kinetic energy passes through predetermined heart 5 tissue and enters receiving cavity.
Lifting release receives snapholder 7-7, upper spring 4-4 and lower spring 4-5 abrupt release, receives connecting rod 4-2 in promotion
It is moved with lower reception connecting rod 4-3, and then clamps the puncture needle 6 projected in storage needle cavity 3-3.
Liftable operating stick 7 is risen, pulls back and receives snapholder, takes out the puncture needle 6 with ligature, carries out next step knot
It pricks.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to restrict the invention, it is all in spirit of the invention and
In principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (12)
1. a kind of puncture outfit of Neonatal Mouse heart infarction model, which is characterized in that the puncture outfit includes that middle part sets reeded structure
Part, left part are equipped with the emission system of puncture needle, and right part is equipped with the reception system of puncture needle；The inner surface of the groove and suckling mouse
The outer surface of heart fits.
2. puncture outfit according to claim 1, which is characterized in that the emission system includes transmitting spring, the company of pushing pin
Bar and storage needle cavity, the one end for emitting spring are close to the one end for connecting rod of pushing pin, and the other end for connecting rod of pushing pin protrudes into storage needle cavity, release
After emitting spring, connecting rod of pushing pin will push the puncture needle in storage needle cavity to project outward.
3. puncture outfit according to claim 1 or 2, which is characterized in that the reception system includes receiving cavity, upper reception
Connecting rod, lower reception connecting rod, upper spring, lower spring, one end of upper spring are close to upper one end for receiving connecting rod, upper reception connecting rod
The other end is placed in receiving cavity, and one end of lower spring is close to lower one end for receiving connecting rod, and the lower other end for receiving connecting rod is placed in
In receiving cavity, discharges upper spring and lower spring pushes receive connecting rod and lower reception link motion respectively, and then clamp from storage
The puncture needle projected in needle cavity.
4. puncture outfit according to claim 1, which is characterized in that the puncture outfit still further comprises liftable operation
Bar, release transmitting spring steel wire, pulling back emits spring steel wire, and release transmitting snapholder, pulling back emits snapholder, and release receives bullet
Spring steel wire, pulling back receives spring steel wire, and release reception snapholder, pulling back receives snapholder；Wherein the release emits spring steel
One end of silk passes through liftable operating stick and connect with transmitting spring, and the other end of the release transmitting spring steel wire and release emit
Snapholder connection, it is described pull back emit spring steel wire one end pass through liftable operating stick with emit spring connect, it is described to pull back
Emit the other end of spring steel wire and emits snapholder and connect with pulling back.
5. puncture outfit according to claim 4, which is characterized in that one end that the release receives spring steel wire passes through and can rise
Drop operating stick is connect with upper spring and lower spring, and the release receives the other end of spring steel wire and release receives snapholder and connects
Connect, it is described pull back receive spring steel wire one end pass through liftable operating stick connect with upper spring and lower spring, described pull back connects
It receives the other end of spring steel wire and receives snapholder and connect with pulling back.
6. puncture outfit described according to claim 1 or 2 or 4 or 5, which is characterized in that the puncture outfit still further comprises knot
Binding and line room is deposited, the ligature, which is placed in, to be deposited in line room, and one end is connect with puncture needle.
7. a kind of sting device comprising just like puncture outfit described in claim 1-6, which is characterized in that further include having:
Handle, liftable operating stick are set to the point of intersection of the handle；
Horse shoe clamp is made of left horse shoe clamp and right horse shoe clamp, is respectively arranged at one end of handle, for outflanking heart formation.
8. sting device according to claim 7, which is characterized in that left horse shoe clamp is identical with right ungulate clamping structure, by
Similar ellipse and similar trapezoidal steel wire form, which is characterized in that the entire loop-drive of similar ellipse is described similar in a shape
Trapezoidal middle line is vertical with the long axis of the similar ellipse and passes through the central point of similar ellipse；It is described similar trapezoidal upper
Bottom is left a blank, both ends respectively with like ellipse by arc transition in a manner of connect；The similar trapezoidal bottom is left a blank, respectively
Connect with the both ends of other devices；The similar trapezoidal spill that faces down is at a cambered surface.
9. sting device according to claim 8, which is characterized in that left horse shoe clamp and right horse shoe clamp have steel wire to be made.
10. sting device according to claim 9, which is characterized in that the cambered surface is with 60 ° of central angles, radius 1.4cm
The cambered surface for being 1.466cm for arc length caused by standard.
11. according to the described in any item sting devices of claim 8-10, which is characterized in that the long axis of the similar ellipse is about
For 1cm, short axle is about 0.8cm；The similar trapezoidal upper bottom is about 0.4cm, and bottom is about 0.8cm, and height is about 1.2cm.
12. a kind of application method of the sting device as described in claim 7-11, which is characterized in that this method comprises:
A, operation handle makes to enter from oblique cutting at left and right sides of heart respectively from left horse shoe clamp and the right side are ungulate, outflanks heart formation, solve
Determined puncture when heart double swerve possibility；
B, liftable operating stick is reduced, is close to the inner surface of the groove of puncture outfit with the outside of heart, ensure that heart or more
The possibility of fluctuation；
C, lifting release transmitting snapholder, transmitting elastic potential energy of the spring release, moment push pin connecting rod, and connecting rod of pushing pin is by kinetic energy
It is transferred to puncture needle, puncture needle, which obtains after kinetic energy passes through predetermined heart tissue, enters receiving cavity；
D, lifting release receives snapholder, upper spring and lower spring abrupt release, and connecting rod is received in promotion promotion and lower reception connects
Bar movement, and then clamp the puncture needle projected in storage needle cavity；
E, liftable operating stick is risen, pulls back and receives snapholder, takes out the puncture needle with ligature, carries out next step ligation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811094409.9A CN109124809B (en) | 2018-09-19 | 2018-09-19 | Neonatal suckling mouse myocardial infarction model puncture outfit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811094409.9A CN109124809B (en) | 2018-09-19 | 2018-09-19 | Neonatal suckling mouse myocardial infarction model puncture outfit |
Publications (2)
| Publication Number | Publication Date |
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| CN109124809A true CN109124809A (en) | 2019-01-04 |
| CN109124809B CN109124809B (en) | 2023-09-01 |
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ID=64815182
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| CN201811094409.9A Active CN109124809B (en) | 2018-09-19 | 2018-09-19 | Neonatal suckling mouse myocardial infarction model puncture outfit |
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| CN205913421U (en) * | 2016-06-01 | 2017-02-01 | 中国人民解放军第二军医大学 | Blood suit is got to heart |
| CN106806035A (en) * | 2016-08-25 | 2017-06-09 | 张国刚 | A kind of method for setting up myocardial infarction model |
| CN207613841U (en) * | 2017-05-11 | 2018-07-17 | 贵州医科大学附属医院 | A kind of laparoscope puncture outfit |
| CN108158692A (en) * | 2017-12-29 | 2018-06-15 | 卢乐 | Three-hand type ox abomasal displacement restorer |
| CN108420566A (en) * | 2018-03-09 | 2018-08-21 | 重庆医药高等专科学校 | Blood-taking device for experimental mouse |
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| CN109124809B (en) | 2023-09-01 |
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