CN109106464B - Device and fixing mechanism for preparing spinal cord injury experimental model - Google Patents

Abstract

The invention provides a device and a fixing mechanism for preparing a spinal cord injury experimental model, including a damage mechanism and a fixation mechanism. The fixation mechanism is located below the damage mechanism. The fixation mechanism and the damage mechanism are independent of each other and their relative positions are adjustable; The damage mechanism includes an adjustment base, and a damage clamping head is installed on the adjustment base; wherein, the bottom of the first clamping piece is provided with a limiting protrusion, and the bottom of the second clamping piece is provided with a limiting block. When the limiting protrusion contacts the limiting block, the distance between the first clamping pin and the second clamping pin is equal. Through the cooperation of the damage mechanism and the clamping mechanism, the device of the present invention can increase the stability and accuracy in the preparation process of the spinal cord injury experimental model, can prepare a standardized and unified spinal cord injury experimental model, and can perform subsequent pathological assessment of spinal cord injury. A good foundation can improve the accuracy and consistency of experimental results.

Description

A device and fixation mechanism for preparing experimental models of spinal cord injury

Technical field

The invention belongs to the field of experimental instruments, relates to spinal cord injury experiments, and specifically relates to a device and a fixing mechanism for preparing a spinal cord injury experimental model.

Background technique

Injuries to the spine and spinal cord often occur in industrial, mining, and traffic accidents, and can occur in batches during wartime and natural disasters. The injuries were serious and complex, with multiple injuries, compound injuries, and complications. Spinal cord injury is most common among young adults aged 16-30, which not only brings a catastrophic physical and psychological impact to individuals, but also places a heavy burden on their families and society. Effective treatment of spinal cord injury has become a key area that urgently needs breakthroughs. In the past few decades, a large amount of research has focused on finding strategies to help functional recovery after spinal cord injury. However, there is still a lack of very effective treatment measures, partly because of the The pathological mechanisms following injury are insufficiently understood. In order to study the pathological mechanism of spinal cord injury, it is usually necessary to first use animal models (spinal cord injury in rats and mice) for research. The basis of the experiment is to have a spinal cord injury experimental model that is consistent, easy to operate, and easy to repeat. In the prior art, experimental models are currently prepared by manually injuring the spinal cords of rats and mice with sharp instruments. However, this purely manual operation results in pathological damage to the experimental models each time due to factors such as different operators and varying intensity. The degree is different, and it is difficult to repeat experiments. It is difficult to compare parallel experiments due to different experimental models.

Contents of the invention

In view of the shortcomings of the existing technology, the purpose of the present invention is to provide a device and a fixing mechanism, a clamping head and a fixing mechanism for preparing a spinal cord injury experimental model, so as to solve the problem of preparing a spinal cord injury experiment through manual clamping in the prior art. model, resulting in technical problems such as inconsistent experimental models and difficulty in comparing experimental results.

In order to solve the above technical problems, the present invention adopts the following technical solutions to achieve:

A device for preparing an experimental model of spinal cord injury, including a damage mechanism and a fixation mechanism, the fixation mechanism is located below the damage mechanism, the fixation mechanism and the damage mechanism are independent of each other and their relative positions are adjustable;

The damage mechanism includes an adjustment base, and a damage clamping head is installed on the adjustment base. The damage clamping head includes a first clamping piece and a second clamping piece, and the top end of the first clamping piece and the third clamping piece. The top ends of the two clamping pieces are fixed together, the first clamping piece and the second clamping piece are arranged in an involute shape from top to bottom, and the first clamping needle is fixed at the bottom end of the first clamping piece. , the bottom end of the second clamping piece is fixed with a second clamping pin;

The bottom of the first clamping piece is provided with a limiting protrusion, and the bottom of the second clamping piece is provided with a limiting block. Each time the limiting protrusion contacts the limiting block, there is a gap between the first clamping pin and the second clamping pin. distances are equal;

The fixing mechanism includes a bottom plate. A pair of upright columns are fixed on the bottom plate. A pair of parallel first sleeves are fixed on the top of the upright columns. The first sleeves are arranged parallel to the bottom plate. Each first sleeve has a horizontal bar passing through it. One end of the rod is fixed with a second sleeve, the second sleeve is arranged parallel to the bottom plate and perpendicular to the crossbar, and a pair of second sleeves are arranged coaxially;

Each second sleeve is equipped with a fixed threaded barrel. The inner end of the fixed threaded barrel is fixed with an outer end plate. One side of the outer end plate is fixed with a fixed tooth plate that is vertical to the outer end plate. The fixed tooth plate is hinged with One side of the inner end plate and the other side of the inner end plate are fixed with a movable tooth plate that is vertical to the inner end plate. The combination of the fixed tooth plate and the movable tooth plate is used to clamp the spine;

A screw rod is installed in the fixed threaded barrel. The inner end of the screw rod extends out of the fixed threaded barrel. The inner end of the fixed threaded barrel passes through the outer end plate and is rotatably connected to the inner end plate. The outer end of the screw rod extends out of the outer end of the fixed threaded barrel and ends A bolt head is provided, and the angle between the movable teeth and the fixed teeth can be adjusted by turning the screw;

The first sleeve is provided with a first fastening bolt, and the second sleeve is provided with a second fastening bolt.

The invention also has the following technical features:

The adjustment base includes a counterweight base, a detachable longitudinal rail is installed on the counterweight base, a longitudinal slider is installed on the longitudinal rail, and the longitudinal slider is equipped with a fourth fastening bolt;

A rotating base is installed on the longitudinal slide block. The rotating base can rotate around the vertical axis. The rotating base is provided with a first locking handle. A swinging base is installed on the rotating base. The swinging base can swing relative to the rotating base. The swinging base is provided with a second locking handle;

A vertical track is fixed on the swing seat, a vertical slider is installed on the vertical track, and a vertical lifting bolt is installed on the vertical slider. The vertical lifting bolt is used to control the vertical slider to rise and fall on the vertical track. ;

A transverse fixed rail is fixed on the vertical slider, a transverse moving rail is installed on the transverse fixed rail, a transverse movement bolt is installed on the transverse fixed rail, and the transverse movement bolt is used to control the movement of the transverse moving rail on the transverse fixed rail;

A transverse fixed block is installed at the end of the transverse moving rail, and a fixed seat is installed on the transverse fixed block. The fixed seat is used to clamp and fix the damaged clamping head, and the fixed seat is equipped with a fifth fastening bolt.

The counterweight base is provided with a plurality of installation holes, and the bottom of the longitudinal track is provided with a pair of installation columns. The installation columns are inserted into the installation holes, and the installation holes are equipped with third fastening bolts for locking installation. column.

The vertical rail and the vertical slider, the transverse fixed rail and the transverse moving rail are all driven by gears and racks, and the vertical lifting bolts and transverse movement bolts are connected to the gears.

The longitudinal slide block, rotating seat, swing seat, vertical track and transverse moving track are all provided with scale bars.

The first clamping needle and the second clamping needle are both in the shape of a quadrangular pyramid.

The limiting block is detachably installed on the second clamping piece.

A plurality of through holes are processed on both the first clamping piece and the second clamping piece.

The invention also protects a fixing mechanism, which includes a bottom plate. A pair of upright columns are fixed on the bottom plate. A pair of parallel first sleeves are fixed on the top of the upright columns. The first sleeves are arranged parallel to the bottom plate. Each first sleeve has a A crossbar, one end of which is fixed with a second sleeve, the second sleeve is arranged parallel to the bottom plate and perpendicular to the crossbar, and a pair of second sleeves are arranged coaxially;

Each second sleeve is equipped with a fixed threaded barrel. The inner end of the fixed threaded barrel is fixed with an outer end plate. One side of the outer end plate is fixed with a fixed tooth plate that is vertical to the outer end plate. The fixed tooth plate is hinged with One side of the inner end plate and the other side of the inner end plate are fixed with a movable tooth plate that is vertical to the inner end plate. The combination of the fixed tooth plate and the movable tooth plate is used to clamp the spine;

A screw rod is installed in the fixed threaded barrel. The inner end of the screw rod extends out of the fixed threaded barrel. The inner end of the fixed threaded barrel passes through the outer end plate and is rotatably connected to the inner end plate. The outer end of the screw rod extends out of the outer end of the fixed threaded barrel and ends A bolt head is provided, and the angle between the movable teeth and the fixed teeth can be adjusted by turning the screw;

The first sleeve is provided with a first fastening bolt, and the second sleeve is provided with a second fastening bolt.

Compared with the existing technology, the present invention has the following technical effects:

(Ⅰ) The device of the present invention can increase the stability and accuracy in the preparation process of spinal cord injury experimental models through the cooperation of the damage mechanism and the clamping mechanism, and can prepare a standardized and unified spinal cord injury experimental model. For subsequent spinal cord injuries, A good foundation for pathological assessment can improve the accuracy and consistency of experimental results. The device of the invention is easy to operate, has low cost and is convenient for industrial promotion.

(II) The fixing mechanism of the present invention can clamp the spine very stably, making it convenient for experimental operators to operate during the preparation of spinal cord injury experimental models. The fixing mechanism has a large adjustable range and is widely applicable. The clamping degree is adjusted through the screw rod. The structure is simple and easy to use.

Description of the drawings

Figure 1 is a schematic diagram of the overall structure of the present invention.

Figure 2 is a schematic structural diagram of the fixing mechanism of the present invention.

Figure 3 is a structural schematic diagram of the damage mechanism of the present invention from one perspective.

Figure 4 is a schematic structural diagram of the damage mechanism of the present invention from another perspective.

Figure 5 is a schematic structural diagram of the damaged clamping head.

The meaning of each number in the figure is: 1-damage mechanism, 2-fixing mechanism, 3-adjustment base, 4-damage clamping head, 5-scale bar;

201-bottom plate, 202-column, 203-first sleeve, 204-cross bar, 205-second sleeve, 206-fixed threaded barrel, 207-outer end plate, 208-fixed tooth plate, 209-inner end plate , 210-movable tooth plate, 211-screw, 212-bolt head, 213-first fastening bolt, 214-second fastening bolt;

301-Counterweight base, 302-Longitudinal track, 303-Longitudinal slider, 304-Mounting hole, 305-Mounting column, 306-Third fastening bolt, 307-Fourth fastening bolt, 308-Swivel base, 309- First locking handle, 310-swing seat, 311-second locking handle, 312-vertical track, 313-vertical slider, 314-vertical lifting bolt, 315-lateral fixed track, 316-lateral moving track, 317 -Transverse movement bolt, 318-lateral fixed block, 319-fixed seat, 320-fifth fastening bolt;

401-first clamping piece, 402-second clamping piece, 403-first clamping pin, 404-second clamping pin, 405-limiting protrusion, 406-limiting block, 407-through hole.

The specific content of the present invention will be further explained in detail below with reference to the examples.

Detailed ways

Specific embodiments of the present invention are given below. It should be noted that the present invention is not limited to the following specific embodiments. All equivalent transformations based on the technical solution of this application fall within the protection scope of the present invention.

Example 1:

Following the above technical solution, as shown in Figure 2, this embodiment provides a fixing mechanism, which includes a base plate 201. A pair of upright columns 202 are fixed on the base plate 201. A pair of parallel first sleeves 203 are fixed on the top of the upright columns 202. The first The sleeves 203 are arranged in parallel with the bottom plate 201. Each first sleeve 203 has a cross bar 204 passed through it. One end of the cross bar 204 is fixed with a second sleeve 205. The second sleeve 205 is arranged in parallel with the bottom plate 201 and is connected with the bottom plate 201. The crossbar 204 is arranged vertically, and a pair of second sleeves 205 are arranged coaxially;

Each second sleeve 205 is equipped with a fixed threaded barrel 206. The inner end of the fixed threaded barrel 206 is fixed with an outer end plate 207. One side of the outer end plate 207 is fixed with a fixed tooth plate 208 perpendicular to the outer end plate 207. , one side of the fixed tooth plate 208 is hinged with the inner end plate 209, and the other side of the inner end plate 209 is fixed with a movable tooth plate 210 perpendicular to the inner end plate 209. The cooperation between the fixed tooth plate 208 and the movable tooth plate 210 To hold the spine;

A screw rod 211 is installed in the fixed threaded barrel 206. The inner end of the screw rod 211 extends out. The inner end of the fixed threaded barrel 206 passes through the outer end plate 207 and is rotatably connected to the inner end plate 209. The outer end of the screw rod 211 extends out of the fixed thread. The outer end of the barrel 206 is provided with a bolt head 212, and the angle between the movable tooth plate 210 and the fixed tooth plate 208 can be adjusted by turning the screw 211;

The first sleeve 203 is provided with a first fastening bolt 213 , and the second sleeve 205 is provided with a second fastening bolt 214 .

Example 2:

Following the above technical solution, as shown in Figures 1 to 5, this embodiment provides a device for preparing an experimental model of spinal cord injury, which is characterized in that it includes an injury mechanism 1 and a fixation mechanism 2. The fixation mechanism 2 Located below the damage mechanism 1, the fixation mechanism 2 and the damage mechanism 1 are independent of each other and their relative positions are adjustable;

The damage mechanism 1 includes an adjustment base 3, and a damage clamping head 4 is installed on the adjustment base 3. The damage clamping head 4 includes a first clamping piece 401 and a second clamping piece 402. The top end of the clamping piece 401 and the top end of the second clamping piece 402 are fixed together. The first clamping piece 401 and the second clamping piece 402 are arranged in an involute shape from top to bottom. The bottom end of 401 is fixed with a first clamping needle 403, and the bottom end of the second clamping piece 402 is fixed with a second clamping needle 404;

The bottom of the first clamping piece 401 is provided with a limiting protrusion 405, and the bottom of the second clamping piece 402 is provided with a limiting block 406. Each time the limiting protrusion 405 and the limiting block 406 contact, the first clamping pin 403 and The distance between the second clamping pins 404 is equal;

The fixing mechanism 2 adopts the fixing mechanism described in the embodiment.

As a preferred solution of this embodiment, both the first clamping needle 403 and the second clamping needle 404 are in the shape of a quadrangular pyramid, which facilitates clamping damage.

As a preferred solution of this embodiment, the limiting block 406 is detachably installed on the second clamping piece 402 . The limiting block 406 can be replaced with different thicknesses according to different damage requirements, and the distance between the first clamping needle 403 and the second clamping needle 404 can be adjusted.

As a preferred solution of this embodiment, a plurality of through holes 407 are processed on both the first clamping piece 401 and the second clamping piece 402 to reduce the friction between the first clamping piece 401 and the second clamping piece 402. The stiffness brought by the material itself facilitates clamping, while also reducing weight and saving materials.

As a specific solution of this embodiment, the adjustment base 3 includes a counterweight base 301. A detachable longitudinal rail 302 is installed on the counterweight base 301. A longitudinal slider 303 is installed on the longitudinal rail 302. The longitudinal slider 303 is It is equipped with the fourth fastening bolt 307;

A rotating base 308 is installed on the longitudinal slider 303. The rotating base 308 can rotate around the vertical axis. The rotating base 308 is provided with a first locking handle 309. A swinging base 310 is installed on the rotating base 308. The swinging base 310 can rotate relatively. The base 308 swings, and the swing base 310 is provided with a second locking handle 311;

A vertical rail 312 is fixed on the swing seat 310. A vertical slider 313 is installed on the vertical rail 312. A vertical lifting bolt 314 is installed on the vertical slider 313. The vertical lifting bolt 314 is used to control the vertical slide. The block 313 is raised and lowered on the vertical track 312;

A transverse fixed rail 315 is fixed on the vertical slider 313. A transverse moving rail 316 is installed on the transverse fixed rail 315. A transverse movement bolt 317 is installed on the transverse fixed rail 315. The transverse movement bolt 317 is used to control the movement of the transverse movement rail 316. Move on the transverse fixed track 315;

A transverse fixing block 318 is installed at the end of the transverse moving rail 316. A fixing base 319 is installed on the transverse fixing block 318. The fixing base 319 is used to clamp and fix the damaged clamping head 4. The fixing base 319 is equipped with a fifth fastening bolt. 320.

As a preferred solution of this embodiment, the counterweight base 301 is provided with a plurality of mounting holes 304. The bottom of the longitudinal track 302 is provided with a pair of mounting posts 305. The mounting posts 305 are inserted into the mounting holes 304. The mounting holes 304 is equipped with a third fastening bolt 306 for locking the mounting column 305.

As a preferred solution of this embodiment, the vertical rail 312 and the vertical slider 313, and the horizontal fixed rail 315 and the horizontal moving rail 316 are all driven by gears and racks, and the vertical lifting bolts 314 and the horizontal The moving bolts 317 are all connected with the gears. Easy to adjust.

As a preferred solution of this embodiment, scale bars 5 are provided on the longitudinal slider 303, the rotating base 308, the swinging base 310, the vertical track 312 and the transverse moving track 316 to facilitate position adjustment.

When the device of this embodiment is used, the spine of the rat or mouse is first fixed through the fixing mechanism 2. The two ends of the spine are respectively clamped between the movable tooth plate 210 and the fixed tooth plate 208. By rotating the screw 211, the movable tooth plate can be driven By opening and closing 210, each connecting structure in the fixing mechanism 2 can be adjusted and stretched to adjust and clamp different vertebrae.

After fixing the spine, the fixation mechanism 2 is placed on the counterweight base 301 directly below the injury clamping head 4, and the specific lateral, longitudinal and vertical positions of the injury clamping head 4 are adjusted by adjusting each movable joint on the base 3. The first clamping needle 403 and the second clamping needle 404 of the damaged clamping head 4 are driven by the operator pinching the first clamping piece 401 and the second clamping piece 402. The first clamping needle 403 and the second clamping needle 404 causes damage to the spinal cord to form an injury model. Every time the first clamping piece 401 and the second clamping piece 402 are pinched, no matter how big or small the force is, due to the limiting effect of the limiting protrusion 405 and the limiting block 406, the distance is constant every time, ensuring the stability of the experiment. sex.

Claims (5)

1. A device for preparing an experimental model of spinal cord injury, characterized in that it includes an injury mechanism (1) and a fixation mechanism (2). The fixation mechanism (2) is located below the injury mechanism (1). The fixation mechanism (2) Independent of each other and the damage mechanism (1) and the relative position is adjustable; The damage mechanism (1) includes an adjustment base (3), and a damage clamping head (4) is installed on the adjustment base (3). The damage clamping head (4) includes a first clamping piece ( 401) and the second clamping piece (402), the top end of the first clamping piece (401) and the top end of the second clamping piece (402) are fixed together, the first clamping piece (401) and the second clamping piece (402) are fixed together. The holding pieces (402) are arranged in an involute shape from top to bottom. The bottom end of the first holding piece (401) is fixed with a first holding needle (403), and the bottom end of the second holding piece (402) is fixed with a first holding needle (403). The end is fixed with a second clamping pin (404); The bottom of the first clamping piece (401) is provided with a limiting protrusion (405), and the bottom of the second clamping piece (402) is provided with a limiting block (406). Each time the limiting protrusion (405) and the limiting block (406) When in contact, the distance between the first clamping pin (403) and the second clamping pin (404) is equal; The fixing mechanism (2) includes a bottom plate (201). A pair of upright columns (202) are fixed on the bottom plate (201). A pair of parallel first sleeves (203) are fixed on the top of the upright columns (202). The first sleeves (203) are fixed on the bottom plate (201). 203) is arranged parallel to the bottom plate (201). Each first sleeve (203) has a cross bar (204) inserted inside. One end of the cross bar (204) is fixed with a second sleeve (205). The second sleeve The barrel (205) is arranged parallel to the bottom plate (201) and perpendicular to the crossbar (204), and a pair of second sleeves (205) are arranged coaxially; Each second sleeve (205) is equipped with a fixed threaded barrel (206), an outer end plate (207) is fixed at the inner end of the fixed threaded barrel (206), and one side of the outer end plate (207) is fixed with Fixed tooth plate (208) of the vertical outer end plate (207). One side of the fixed tooth plate (208) is hinged with the inner end plate (209), and the other side of the inner end plate (209) is fixed with a vertical inner end. The cooperation of the movable tooth plate (210) of the plate (209), the fixed tooth plate (208) and the movable tooth plate (210) is used to clamp the spine; A screw rod (211) is installed in the fixed threaded barrel (206). The inner end of the screw rod (211) extends out of the fixed threaded barrel (206) and passes through the outer end plate (207) and is rotatable with the inner end plate (209). The outer end of the screw rod (211) extends out of the outer end of the fixed thread barrel (206) and is provided with a bolt head (212) at the end. The movable tooth plate (210) and the fixed tooth plate can be adjusted by turning the screw rod (211). (208) the angle between; The first sleeve (203) is provided with a first fastening bolt (213), and the second sleeve (205) is provided with a second fastening bolt (214); The adjustment base (3) includes a counterweight base (301), a removable longitudinal track (302) is installed on the counterweight base (301), and a longitudinal slider (303) is installed on the longitudinal track (302). The longitudinal slider (303) is equipped with a fourth fastening bolt (307); A rotating base (308) is installed on the longitudinal slider (303). The rotating base (308) can rotate around the vertical axis. A first locking handle (309) is provided on the rotating base (308); A swing base (310) is installed, the swing base (310) can swing relative to the rotating base (308), and a second locking handle (311) is provided on the swing base (310); A vertical track (312) is fixed on the swing seat (310), a vertical slider (313) is installed on the vertical track (312), and a vertical lifting bolt (314) is installed on the vertical slider (313). , the vertical lifting bolt (314) is used to control the vertical slider (313) to rise and fall on the vertical track (312); A transverse fixed rail (315) is fixed on the vertical slider (313), a transverse moving rail (316) is installed on the transverse fixed rail (315), and a transverse moving bolt (317) is installed on the transverse fixed rail (315). The transverse movement bolt (317) is used to control the movement of the transverse movement rail (316) on the transverse fixed rail (315); A transverse fixed block (318) is installed at the end of the transverse moving rail (316), and a fixed base (319) is installed on the transverse fixed block (318). The fixed base (319) is used to clamp and fix the damaged clamping head (4) , the fixed base (319) is equipped with a fifth fastening bolt (320); The counterweight base (301) is provided with a plurality of mounting holes (304), and the bottom of the longitudinal track (302) is provided with a pair of mounting posts (305). The mounting posts (305) are inserted into the mounting holes (304). ), the mounting hole (304) is equipped with a third fastening bolt (306) for locking the mounting column (305); The vertical rail (312) and the vertical slider (313), and the transverse fixed rail (315) and the transverse moving rail (316) are all driven by gears and racks, and the vertical lifting bolts (314) ) and the transverse movement bolt (317) are both connected to the gear. 2. The device for preparing an experimental model of spinal cord injury according to claim 1, characterized in that the longitudinal slider (303), the rotating seat (308), the swinging seat (310), the vertical track (312) ) and the transverse moving track (316) are provided with scale bars (5). 3. The device for preparing an experimental model of spinal cord injury according to claim 1, characterized in that the first clamping needle (403) and the second clamping needle (404) are both in the shape of a quadrangular pyramid. 4. The device for preparing an experimental model of spinal cord injury according to claim 1, characterized in that the limiting block (406) is detachably installed on the second clamping piece (402). 5. The device for preparing an experimental model of spinal cord injury according to claim 1, characterized in that, the first clamping piece (401) and the second clamping piece (402) are both processed with a plurality of through-holes. hole(407).