CN109106464A

CN109106464A - A kind of device and fixed mechanism being used to prepare spinal cord injury experimental model

Info

Publication number: CN109106464A
Application number: CN201810921062.4A
Authority: CN
Inventors: 樊洪; 鞠躬
Original assignee: Fourth Military Medical University FMMU
Current assignee: Air Force Medical University
Priority date: 2018-08-14
Filing date: 2018-08-14
Publication date: 2019-01-01
Anticipated expiration: 2038-08-14
Also published as: CN109106464B

Abstract

The invention provides a device and a fixing mechanism for preparing an experimental model of spinal cord injury, including an injury mechanism and a fixing mechanism, the fixing mechanism is located below the injury mechanism, and the fixing mechanism and the injury mechanism are independent of each other and their relative positions can be adjusted; The damage mechanism includes an adjustment base on which a damage clamping head is installed; wherein, the bottom of the first holding piece is provided with a limit protrusion, and the bottom of the second holding piece is provided with a limit block, and each time limit The distance between the first clamping needle and the second clamping needle is equal when the protrusion and the limit block are in contact. Through the cooperation of the injury mechanism and the clamping mechanism, the device of the present invention can increase the stability and accuracy in the preparation process of the spinal cord injury experimental model, and can prepare a standardized and unified spinal cord injury experimental model, which can be used for the subsequent pathological evaluation of spinal cord injury. A good foundation can improve the accuracy and consistency of experimental results.

Description

A kind of device and fixed mechanism being used to prepare spinal cord injury experimental model

Technical field

The invention belongs to test instrument field, it is related to spinal cord injury experiment, and in particular to one kind is used to prepare spinal cord injury The device and fixed mechanism of experimental model.

Background technique

Backbone, spinal cord injury can occur in batch when often betiding industrial and mineral, traffic accident, wartime and natural calamity.The condition of the injury is tight Repetition is miscellaneous, and multiple injury, combined injury are more, and complication is more.Spinal cord injury is high-incidence in 16-30 years old Young crowd, not only to individual Physiology and the strike of bringing on a disaster property of psychology, while heavy burden is brought to its family and society.The effective treatment of spinal cord injury is As the major fields for being badly in need of breaking through, in the past few decades, numerous studies, which concentrate on searching, facilitates functional rehabilitation after spinal cord injury Strategy process, but still lack highly effective remedy measures at present, be partly because to pathomechanism after spinal cord injury Understanding is not enough.In order to study the pathomechanism of spinal cord injury, it usually needs first using animal model (rats and mice spinal cord damage Wound) studied, and test basis be consistency to be had it is good, it is easy to operate, be easy to duplicate spinal cord injury experimental model.It is existing It is all manually to cause damage to prepare experimental model in rats and mice spinal cord by sharp weapon at present in technology, but it is this pure artificial Operation leads to pathology damage journey caused by each experimental model since each operator is different and the not first-class influence factor of dynamics It spends all different, it is difficult to repeat to test, be difficult have contrastive due to the difference of experimental model between parallel experiment.

Summary of the invention

In view of the deficiencies of the prior art, the present invention intends to provide one kind and be used to prepare spinal cord injury experiment Device and fixed mechanism, the clamping head and fixed mechanism of model solve in the prior art through manually clamping preparation spinal cord injury Experimental model causes experimental model disunity, is difficult to the technical issues of comparing between experimental result.

In order to solve the above-mentioned technical problem, the present invention is realised by adopting the following technical scheme:

A kind of device being used to prepare spinal cord injury experimental model, including injury mechanism and fixed mechanism, the fixation Mechanism is located at the lower section of injury mechanism, and fixed mechanism is mutually indepedent with injury mechanism and relative position is adjustable；

The injury mechanism includes adjusting pedestal, adjusts installation on pedestal and has damage clamping head, the damage clamping Head includes the first clamping piece and the second clamping piece, and the top of the top of the first clamping piece and the second clamping piece is consolidated, the From the top to the bottom in shape setting is gradually opened between one clamping piece and the second clamping piece, the bottom end of the first clamping piece is consolidated with the first folder Needle is held, the bottom end of the second clamping piece is consolidated with the second clamping needle；

The bottom of first aid piece is provided with retention bead, and the bottom of the second aid piece is provided with limited block, limits every time The distance between the first clamping needle and the second clamping needle are equal when protrusion and limited block contact；

The fixed mechanism includes bottom plate, is fixed with a column on bottom plate, is fixed at the top of column a pair of parallel First sleeve, first sleeve are arranged in parallel with bottom plate, and a cross bar is installed in each sleeve, and one end of cross bar is consolidated with second set Cylinder, second sleeve are arranged in parallel with bottom plate and are vertically arranged with cross bar, and a pair of of second sleeve is coaxially arranged；

A fixed thread cylinder is set in each second sleeve, the inner end of fixed thread cylinder is fixed with outer end plate, outer end The side of plate is consolidated with the fixed tooth plate of vertical outer end plate, is hinged with the side of inner end plate on fixed tooth plate, inner end plate it is another Side is consolidated with the swing tooth plate of vertical inner end plate, and the cooperation of fixed tooth plate and swing tooth plate is for clamping vertebra；

Screw rod is installed in fixed thread cylinder, the inner end that fixed thread cylinder is stretched out in the inner end of screw rod pass through outer end plate and with it is interior End plate is turnably connected, and the outer end of thread barrel is stretched out in the outer end of screw rod and end is provided with bolt head, rotation screw rod, that is, adjustable Save the angle between movable teeth and fixed tooth；

It is provided with the first fastening bolt in first sleeve, the second fastening bolt is provided in second sleeve.

The present invention also has following technical characteristic:

The adjusting pedestal includes counter weight base, and dismountable long rails, long rails are equipped on counter weight base On longitudinal sliding block is installed, the 4th fastening bolt is configured on longitudinal sliding block；

Rotation seat is installed, rotation seat can be rotated around vertical axis, and the first lock is provided on rotation seat on longitudinal sliding block Determine handle；Swinging seat is installed, swinging seat is relatively rotatable to each other seat swing, is provided with the second locking hand on swinging seat on rotation seat Handle；

It is consolidated with vertical track on swinging seat, vertical sliding block is installed on vertical track, is equipped on vertical sliding block vertical Lifting bolt, vertical lifting bolt are gone up and down on vertical track for controlling vertical sliding block；

It is consolidated with lateral trapped orbit on vertical sliding block, transverse shifting track is installed on lateral trapped orbit, it is laterally solid Transverse movement bolt is installed, transverse movement bolt is transported on lateral trapped orbit for controlling transverse shifting track on orbit determination road It is dynamic；

The end of transverse movement track is equipped with lateral fixed block, and fixing seat is equipped on lateral fixed block, and fixing seat is used In gripping damage clamping head, the 5th fastening bolt is configured in fixing seat.

Multiple mounting holes are provided on the counter weight base, the bottom of the long rails is provided with a pair of of installation Column, mounting post are inserted in mounting hole, third fastening bolt are configured on mounting hole, for locking mounting post.

Pass through gear between the vertical track and vertical sliding block, between lateral trapped orbit and transverse movement track Cooperate with rack gear and be driven, vertical lifting bolt and transverse movement bolt are connected with gear.

Scale strip is provided on the longitudinal sliding block, rotation seat, swinging seat, vertical track and transverse shifting track.

The first clamping needle and the second clamping needle is in tetrapyamid shape.

The limited block is removably mounted on the second clamping piece.

Multiple through-holes are machined on first clamping piece and the second clamping piece.

The present invention also protects a kind of fixed mechanism, including bottom plate, and a column is fixed on bottom plate, is fixed at the top of column A pair of parallel first sleeve, first sleeve are arranged in parallel with bottom plate, and a cross bar is installed in each sleeve, and one end of cross bar is solid Second sleeve is had, second sleeve is arranged in parallel with bottom plate and is vertically arranged with cross bar, and a pair of of second sleeve is coaxially arranged；

Compared with prior art, the present invention having the following technical effect that

(I) the device of the invention passes through the cooperation of injury mechanism and clamping device, can increase spinal cord injury experimental model Stability and accuracy in preparation process can prepare standardized unified spinal cord injury experimental model, for subsequent Spinal cord injury pathology assessment carry out basis, so as to improve the accuracy and consistency of experimental result.The device of the invention Easy to operate, cost is relatively low, is convenient for industrialization promotion.

(II) fixed mechanism of the invention can steadily clamp vertebra very much, in spinal cord injury experimental model preparation process Experiment operator is facilitated to operate, the adjustable range of fixed mechanism is larger, and it is widely applicable, clamping degree is adjusted by screw rod, Structure is simple, easy to use.

Detailed description of the invention

Fig. 1 is overall structure diagram of the invention.

Fig. 2 is the structural schematic diagram of fixed mechanism of the invention.

Fig. 3 is the structural schematic diagram at a visual angle of injury mechanism of the invention.

Fig. 4 is the structural schematic diagram at another visual angle of injury mechanism of the invention.

Fig. 5 is the structural schematic diagram for damaging clamping head.

The meaning of each label in figure are as follows: 1- injury mechanism, 2- fixed mechanism, 3- adjust pedestal, and 4- damages clamping head, 5- Scale strip；

201- bottom plate, 202- column, 203- first sleeve, 204- cross bar, 205- second sleeve, 206- fixed thread cylinder, 207- outer end plate, 208- fixed tooth plate, 209- inner end plate, 210- swing tooth plate, 211- screw rod, 212- bolt head, 213- first Fastening bolt, the second fastening bolt of 214-；

301- counter weight base, 302- long rails, 303- longitudinal sliding block, 304- mounting hole, 305- mounting post, 306- third Fastening bolt, the 4th fastening bolt of 307-, 308- rotation seat, the first lock handle of 309-, 310- swinging seat, 311- second are locked Handle, the vertical track of 312-, the vertical sliding block of 313-, 314- vertical lifting bolt, 315- transverse direction trapped orbit, 316- transverse shifting Track, 317- transverse movement bolt, 318- transverse direction fixed block, 319- fixing seat, the 5th fastening bolt of 320-；

The first clamping piece of 401-, the second clamping piece of 402-, 403- first clamp needle, and 404- second clamps needle, 405- limit Protrusion, 406- limited block, 407- through-hole.

Explanation is further explained in detail to particular content of the invention with reference to embodiments.

Specific embodiment

Specific embodiments of the present invention are given below, it should be noted that the invention is not limited to implement in detail below Example, all equivalent transformations made on the basis of the technical solutions of the present application each fall within protection scope of the present invention.

Embodiment 1:

In compliance with the above technical solution, as shown in Fig. 2, the present embodiment provides a kind of fixed mechanism, including bottom plate 201, bottom plate It is fixed with a column 202 on 201, a pair of parallel first sleeve 203, first sleeve 203 and bottom are fixed at the top of column 202 Plate 201 is arranged in parallel, and a cross bar 204 is installed in each sleeve 203, and one end of cross bar 204 is consolidated with second sleeve 205, the Two sleeves 205 are arranged in parallel with bottom plate 201 and are vertically arranged with cross bar 204, and a pair of of second sleeve 205 is coaxially arranged；

A fixed thread cylinder 206 is set in each second sleeve 205, the inner end of fixed thread cylinder 206 is fixed with outer End plate 207, the side of outer end plate 207 are consolidated with the fixed tooth plate 208 of vertical outer end plate 207, are hinged on fixed tooth plate 208 interior The side of end plate 209, the other side of inner end plate 209 are consolidated with the swing tooth plate 210 of vertical inner end plate 209,208 He of fixed tooth plate The cooperation of swing tooth plate 210 is for clamping vertebra；

Screw rod 211 is installed, the inner end that fixed thread cylinder 206 is stretched out in the inner end of screw rod 211 passes through in fixed thread cylinder 206 Outer end plate 207 and turnably it is connected with inner end plate 209, the outer end of thread barrel 206 is stretched out in the outer end of screw rod 211 and end is arranged There is bolt head 212, rotation screw rod 211 is the angle between adjustable swing tooth plate 210 and fixed tooth plate 208；

It is provided with the first fastening bolt 213 in first sleeve 203, is provided with the second fastening bolt in second sleeve 205 214。

Embodiment 2:

In compliance with the above technical solution, as shown in Figures 1 to 5, the present embodiment provides one kind and is used to prepare spinal cord injury experiment The device of model, which is characterized in that including injury mechanism 1 and fixed mechanism 2, the fixed mechanism 2 is located at injury mechanism 1 Lower section, fixed mechanism 2 and injury mechanism 1 are mutually indepedent and relative position is adjustable；

The injury mechanism 1 includes adjusting pedestal 3, adjusts installation on pedestal 3 and has damage clamping head 4, the damage Clamping head 4 includes the first clamping piece 401 and the second clamping piece 402, the top of the first clamping piece 401 and the second clamping piece 402 Top is consolidated, and is from the top to the bottom in gradually to open shape setting between the first clamping piece 401 and the second clamping piece 402, and first The bottom end of clamping piece 401 is consolidated with the first clamping needle 403, and the bottom end of the second clamping piece 402 is consolidated with the second clamping needle 404；

The bottom of first aid piece 401 is provided with retention bead 405, and the bottom of the second aid piece 402 is provided with limited block 406, the distance between the first clamping needle 403 and the second clamping needle 404 phase when each retention bead 405 and limited block 406 contact Deng；

The fixed mechanism 2 uses fixed mechanism as described in the examples.

As a kind of preferred embodiment of the present embodiment, the first clamping needle 403 and the second clamping needle 404 are in tetrapyamid shape, Convenient for Clamping damage.

As a kind of preferred embodiment of the present embodiment, limited block 406 is removably mounted on the second clamping piece 402.Limit Position block 406 can require to replace different thickness, and then adjustable first clamping needle 403 and the second folder according to different damages Hold the distance between needle 404.

As a kind of preferred embodiment of the present embodiment, it is machined on the first clamping piece 401 and the second clamping piece 402 multiple Through-hole 407, for reducing the first clamping piece 401 and the second clamping piece 402 due to material bring rigidity itself, convenient for clamping, Also mitigate weight simultaneously, saves material.

As a kind of concrete scheme of the present embodiment, adjusting pedestal 3 includes counter weight base 301, is installed on counter weight base 301 There are dismountable long rails 302, longitudinal sliding block 303 is installed on long rails 302, is configured with the 4th on longitudinal sliding block 303 Fastening bolt 307；

Rotation seat 308 is installed, rotation seat 308 can be rotated around vertical axis, on rotation seat 308 on longitudinal sliding block 303 It is provided with the first lock handle 309；Swinging seat 310 is installed, swinging seat 310 is relatively rotatable to each other the pendulum of seat 308 on rotation seat 308 It is dynamic, the second lock handle 311 is provided on swinging seat 310；

It is consolidated with vertical track 312 on swinging seat 311, vertical sliding block 313, vertical sliding block are installed on vertical track 312 Vertical lifting bolt 314 is installed, vertical lifting bolt 314 is for controlling vertical sliding block 313 in vertical track 312 on 313 Lifting；

It is consolidated with lateral trapped orbit 315 on vertical sliding block 313, transverse shifting rail is installed on lateral trapped orbit 315 Road 316 is equipped with transverse movement bolt 317 on lateral trapped orbit 315, and transverse movement bolt 317 is for controlling transverse shifting Track 316 moves on lateral trapped orbit 315；

The end of transverse movement track 316 is equipped with lateral fixed block 318, is equipped with fixing seat on lateral fixed block 318 319, fixing seat 319 is configured with the 5th fastening bolt 320 in fixing seat 319 for gripping damage clamping head 4.

As a kind of preferred embodiment of the present embodiment, multiple mounting holes 304 are provided on counter weight base 301, described is vertical The bottom of track 302 is provided with a pair of of mounting post 305, mounting post 305 is inserted in mounting hole 304, mating on mounting hole 304 There is third fastening bolt 306, for locking mounting post 305.

As a kind of preferred embodiment of the present embodiment, between vertical track 312 and vertical sliding block 313, lateral trapped orbit It is driven by gear and rack gear cooperation between 315 and transverse movement track 316, vertical lifting bolt 314 and transverse movement spiral shell Bolt 317 is connected with gear.Facilitate adjustment.

As a kind of preferred embodiment of the present embodiment, longitudinal sliding block 303, rotation seat 308, swinging seat 311, vertical track 312 and transverse shifting track 316 on be provided with scale strip 5, facilitate adjusting position.

The device of the present embodiment when in use, first passes through the vertebra of 2 fixed size mouse of fixed mechanism, the both ends difference of vertebra It is clamped between swing tooth plate 210 and fixed red slope 208, by rotary screw 211, the folding of swing tooth plate 210 can be driven, Each connection structure is adjustable flexible in fixed mechanism 2, clamps different vertebras for adjusting.

Fixed mechanism 2 is placed on the counter weight base 301 immediately below damage clamping head 4 after fixing vertebra, by adjusting base Lateral, longitudinal and vertical specific location of each turning joint adjustment damage clamping head 4 on seat 3.Damage the of clamping head 4 One clamping needle 403 and the second clamping needle 404 are driven by operator's the first clamping piece 401 of kneading and the second clamping piece 402, the One clamping needle 403 and the second clamping needle 404 cause to damage on spinal cord, form damage model.The first clamping piece 401 is mediated every time When with the second clamping piece 402, no matter firmly size, due to the restriction effect of retention bead 405 and limited block 406, it is each away from From be all it is certain, guarantee experiment stability.

Claims

1. a device for preparing an experimental model of spinal cord injury, is characterized in that, comprises damage mechanism (1) and fixation mechanism (2), described fixation mechanism (2) is located below damage mechanism (1), fixation mechanism (2) The damage mechanism (1) is independent of each other and the relative position can be adjusted;

The damage mechanism (1) includes an adjustment base (3), and a damage clamping head (4) is installed on the adjustment base (3), and the damage clamping head (4) includes a first clamping piece ( 401) and the second clamping piece (402), the top end of the first clamping piece (401) and the top end of the second clamping piece (402) are fixed together, the first clamping piece (401) and the second clamping piece (401) The holding pieces (402) are arranged in an involute shape from the top to the bottom, the bottom end of the first holding piece (401) is fixed with a first holding needle (403), and the bottom of the second holding piece (402) is fixed with a first holding pin (403). The end is fixed with a second clamping needle (404);

The bottom of the first holding piece (401) is provided with a limiting protrusion (405), and the bottom of the second holding piece (402) is provided with a limiting block (406), each time the limiting protrusion (405) and the limiting block (406) ) the distance between the first clamping needle (403) and the second clamping needle (404) is equal when they are in contact;

The fixing mechanism (2) comprises a bottom plate (201), a pair of uprights (202) are fixed on the bottom plate (201), and a pair of parallel first sleeves (203) are fixed on the top of the uprights (202), and the first sleeves ( 203) is arranged in parallel with the bottom plate (201), a cross bar (204) is pierced through each sleeve (203), and one end of the cross bar (204) is fixed with a second sleeve (205), the second sleeve ( 205) is arranged parallel to the bottom plate (201) and perpendicular to the cross bar (204), and a pair of second sleeves (205) are arranged coaxially;

Each second sleeve (205) is sleeved with a fixed threaded barrel (206), the inner end of the fixed threaded barrel (206) is fixed with an outer end plate (207), and one side of the outer end plate (207) is fixed with a A fixed tooth plate (208) of the vertical outer end plate (207), one side of the inner end plate (209) is hinged on the fixed tooth plate (208), and the other side of the inner end plate (209) is fixed with a vertical inner end The movable tooth plate (210) of the plate (209), the cooperation of the fixed tooth plate (208) and the movable tooth plate (210) is used for clamping the spine;

A screw (211) is installed in the fixed threaded barrel (206), and the inner end of the screw (211) protrudes from the inner end of the fixed threaded barrel (206) and passes through the outer end plate (207) and is rotatable with the inner end plate (209). The outer end of the screw (211) protrudes from the outer end of the threaded barrel (206) and the end is provided with a bolt head (212). The movable tooth plate (210) and the fixed tooth plate (210) can be adjusted by rotating the screw (211). 208) the angle between;

The first sleeve (203) is provided with a first fastening bolt (213), and the second sleeve (205) is provided with a second fastening bolt (214).

2. The device for preparing an experimental model of spinal cord injury as claimed in claim 1, wherein the adjustment base (3) comprises a counterweight base (301), and a counterweight base (301) is provided with an adjustable base. The disassembled longitudinal rail (302), the longitudinal sliding block (303) is installed on the longitudinal rail (302), and the longitudinal sliding block (303) is matched with a fourth fastening bolt (307);

A rotating seat (308) is installed on the longitudinal sliding block (303), the rotating seat (308) can rotate around a vertical axis, and a first locking handle (309) is arranged on the rotating seat (308); A swing seat (310) is installed, the swing seat (310) can swing relative to the rotation seat (308), and the swing seat (310) is provided with a second locking handle (311);

A vertical rail (312) is fixed on the swing seat (311), a vertical sliding block (313) is installed on the vertical rail (312), and a vertical lifting bolt (314) is installed on the vertical sliding block (313) , the vertical lifting bolt (314) is used to control the vertical sliding block (313) to rise and fall on the vertical rail (312);

A horizontal fixed rail (315) is fixed on the vertical sliding block (313), a horizontal moving rail (316) is installed on the horizontal fixed rail (315), and a horizontal moving bolt (317) is installed on the horizontal fixed rail (315), The lateral movement bolt (317) is used to control the lateral movement rail (316) to move on the lateral fixed rail (315);

A lateral fixing block (318) is installed at the end of the lateral motion track (316), and a fixing seat (319) is installed on the lateral fixing block (318), and the fixing seat (319) is used for clamping and fixing the damage clamping head (4) , the fixing seat (319) is matched with a fifth fastening bolt (320).

3. The device for preparing an experimental model of spinal cord injury according to claim 2, wherein the counterweight base (301) is provided with a plurality of mounting holes (304), the longitudinal rail (302) ) is provided with a pair of mounting posts (305) at the bottom, the mounting posts (305) are inserted into the mounting holes (304), and the mounting holes (304) are provided with third fastening bolts (306) for locking the mounting posts (305). ).

4. The device for preparing an experimental model of spinal cord injury as claimed in claim 2, wherein between the vertical rail (312) and the vertical slider (313), the lateral fixed rail (315) and The lateral movement rails (316) are all driven by gears and racks, and both the vertical lifting bolts (314) and the lateral movement bolts (317) are connected to the gears.

5. The device for preparing a spinal cord injury experimental model according to claim 2, wherein the longitudinal slider (303), the rotating seat (308), the rocking seat (311), the vertical rail (312) ) and the lateral movement track (316) are provided with scale bars (5).

6 . The device for preparing an experimental model of spinal cord injury according to claim 1 , wherein the first clamping needle ( 403 ) and the second clamping needle ( 404 ) are both in the shape of a quadrangular pyramid. 7 .

7 . The device for preparing an experimental model of spinal cord injury according to claim 1 , wherein the limiting block ( 406 ) is detachably mounted on the second clamping piece ( 402 ). 8 .

8. The device for preparing an experimental model of spinal cord injury as claimed in claim 1, wherein the first clamping piece (401) and the second clamping piece (402) are both processed with a plurality of through holes. hole (407).

9. A fixing mechanism, characterized in that it comprises a bottom plate (201), a pair of uprights (202) are fixed on the bottom plate (201), and a pair of parallel first sleeves (203) are fixed on the top of the uprights (202). The sleeves (203) are arranged in parallel with the bottom plate (201), and each sleeve (203) is pierced with a cross bar (204), one end of the cross bar (204) is fixed with a second sleeve (205), the second sleeve (205) is The sleeve (205) is arranged parallel to the bottom plate (201) and perpendicular to the cross bar (204), and a pair of second sleeves (205) are arranged coaxially;