CN109105684A - A kind of glycosylated composition of reduction collagen peptide - Google Patents
A kind of glycosylated composition of reduction collagen peptide Download PDFInfo
- Publication number
- CN109105684A CN109105684A CN201810658478.1A CN201810658478A CN109105684A CN 109105684 A CN109105684 A CN 109105684A CN 201810658478 A CN201810658478 A CN 201810658478A CN 109105684 A CN109105684 A CN 109105684A
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- CN
- China
- Prior art keywords
- parts
- composition
- inspissated juice
- collagen peptide
- collagen
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- Granted
Links
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- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 230000009467 reduction Effects 0.000 title claims abstract description 22
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- 229910021645 metal ion Inorganic materials 0.000 description 1
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- 238000002203 pretreatment Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
The present invention discloses a kind of glycosylated composition of reduction collagen peptide.The component of the composition includes: collagen peptide, haematococcus pluvialis, cherry inspissated juice and pomegranate inspissated juice, there is collaboration to reduce the glycosylated effect of collagen peptide for haematococcus pluvialis, cherry inspissated juice and pomegranate inspissated juice in the composition, so that the utilization rate for improving collagen reaches enhancing delay skin aging effect.It is highly-safe the present invention also provides food and health care product comprising the composition, it is suitble to human body to take for a long time.
Description
Technical field
The present invention relates to food and health product technology field.It is glycosylated more particularly, to a kind of reduction collagen peptide
Composition and its application.
Background technique
Skin is human body largest organ, all can be by the puzzlement of aging as other organs of body.Skin aging point
For exogenous and two kinds of reasons of endogenous.Environmental pollution, undesirable living habit for example indulge in excessive drinking and smoke and sunlight in it is purple
Outside line main extrinsic factor, especially light aging caused by ultraviolet light when irradiating.Skin aging endogenous factor is mainly
Because human body is with advancing age, cell activity decline, cell metabolism is slack-off, and repair ability is deteriorated, immunocompetence decline, from
And the normal physiology cyclic balance of skin is caused to be broken, the collagen in skin is constantly reduced, and moisturizing factor is constantly lost,
Skin pigment increases and the ability decline that is anti-oxidant, removing free radical of skin.This series of aging action of skin can make
Skin loses soft, elasticity and gloss, and skin is made a series of aging phenomena such as wrinkle occur.
Product is generally increased for the demand for improving skin aging by replenishing collagen peptide matters with playing on the market
Add the effect of skin elasticity.But glycosylation (beauty can among human body environments occur when digesting and assimilating in vivo for collagen peptide
Maillard reaction) etc. a series of biochemical reaction, cause the loss of collagen peptide, reduce the effective use of collagen peptide.
Currently, not being reduced the glycosylated effective ways of collagen in the prior art.
Summary of the invention
It is an object of the present invention to provide a kind of glycosylated composition of reduction collagen peptide, the composition can have
Effect reduces the Maillard reaction of collagen peptide, increases the effective use of collagen peptide.
Second object of the present invention is to provide a kind of food or health care product containing above-mentioned composition, safety
Height, it is in good taste, the effect of improving skin aging is had both, is suitble to human body daily health caring edible.
In order to achieve the above objectives, the present invention adopts the following technical solutions:
In a first aspect, the present invention provides a kind of reduction collagen peptide glycosylated composition comprising following components: glue
Former protein peptides, haematococcus pluvialis, cherry inspissated juice and pomegranate inspissated juice.
Optionally, in the composition each component amount are as follows: 3000-18000 parts of collagen peptide, haematococcus pluvialis 5-50
Part, 100-1000 parts of cherry inspissated juice and 100-1000 parts of pomegranate inspissated juice.
Optionally, in the composition each component amount are as follows: 5000-15000 parts of collagen peptide, haematococcus pluvialis 5-30
Part, 100-800 parts of cherry inspissated juice and 100-800 parts of pomegranate inspissated juice.
Optionally, in the composition each component amount are as follows: 6000-12000 parts of collagen peptide, haematococcus pluvialis 5-20
Part, 200-700 parts of cherry inspissated juice and 200-700 parts of pomegranate inspissated juice.
Second aspect, the present invention provide a kind of food or health care product, and it includes above-mentioned reduction collagen peptide is glycosylated
Composition.
Optionally, by mass percentage, in the food containing 50% or more the composition；In the health care product
Contain 50% or more the composition.
Beneficial effects of the present invention are as follows:
A kind of glycosylated composition of reduction collagen peptide provided by the invention, the raw red ball of rain contained in the composition
Algae, cherry inspissated juice and pomegranate inspissated juice not only can individually play its respective function, additionally it is possible to it cooperates each other,
Play the role of reducing collagen peptide Maillard reaction, promotes the absorption and effective use of collagen, to improve collagen
The utilization rate of albumen reaches enhancing delay skin aging effect, and highly-safe, is suitble to people, the daily health caring food of special women
With.
Detailed description of the invention
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment
Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings other
Attached drawing.
Fig. 1 shows the Glycine Levels comparison diagram that each group measures in test example 1.
Fig. 2 shows the proline content comparison diagrams that each group in test example 1 measures.
Specific embodiment
Have the invention discloses one kind and reduces the glycosylated food of collagen peptide.Those skilled in the art can use for reference
Present disclosure is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to this field skill
It is it will be apparent that they are considered as being included in the present invention for art personnel.Method and product of the invention by compared with
Good embodiment is described, related personnel obviously can not depart from the content of present invention, in spirit and scope to as described herein
Method is modified or appropriate changes and combinations, carrys out implementation and application the technology of the present invention.
For a further understanding of the present invention, below in conjunction with the embodiment of the present invention, to the technical side in the embodiment of the present invention
Case is clearly and completely described, it is clear that and described embodiments are only a part of the embodiments of the present invention, rather than all
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art institute without making creative work
The every other embodiment obtained, shall fall within the protection scope of the present invention.
Unless otherwise specified, reagent involved in the embodiment of the present invention is commercial product, can pass through business canal
Road purchase obtains.
For example, cherry inspissated juice (being originated from sweet cherry, acerola concentrate etc., general 3-5 times is concentrated, Brix >=70)；Pomegranate
Inspissated juice (general 6-8 times is concentrated, Brix >=70).
On the one hand, the embodiment of the present invention provides a kind of reduction collagen peptide glycosylated composition, the composition
Component includes: that 3000-18000 parts of collagen peptide, 5-50 parts of haematococcus pluvialis, 100-1000 parts of cherry inspissated juice and pomegranate are dense
100-1000 parts of contracting juice.
It should be noted that in the present composition amount of each component be it is adjustable, in listed range, this hair
It is bright usage ratio each component to be limited, for example, cherry inspissated juice can be when 50 parts of haematococcus pluvialis
500 parts, it is also possible to 700 parts, is counted according to experimental data, significant difference is not present in the test effect of this adjusting.
According to a specific embodiment, in the composition, collagen peptide is 5000-15000 parts, optionally,
6000-12000 parts, can also be such as 7000 parts, 8000 parts, 9000 parts, 10000 parts, 11000 parts etc., or in any of these parts
Any range between number.
According to a specific embodiment, in the composition, haematococcus pluvialis is 5-30 parts, optionally, 5-20 parts,
Can also be such as 6 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts etc., or any range between any of these numbers.
According to a specific embodiment, in the composition, cherry inspissated juice is 100-800 parts, optionally, 200-
700 parts, can also be such as 300 parts, 400 parts, 500 parts, 600 parts etc., or any range between any of these numbers.
According to a specific embodiment, in the composition, pomegranate inspissated juice is 100-800 parts, optionally, 200-
700 parts, can also be such as 300 parts, 400 parts, 500 parts, 600 parts etc., or any range between any of these numbers.
In the present compositions, collagen is the native protein of a kind of unique structure, be distributed widely in cartilage,
In the tissue such as bone, skin, hair, tendon forceps, blood vessel, play a part of protecting body, support organ.Collagen is animal sources egg
Content protein the most abundant, accounts for the 25-30% of total protein in white matter.Glycine Levels highest in collagen accounts for all
27% or so of amino acid.The content of proline and hydroxyproline is also especially high, accounts for 14% or so respectively, and wherein hydroxyproline is
The distinctive amino acid of collagen.Collagen can provide the nutrient of needs for skin regeneration, promote skin repair, can be corium
Layer provides strong support, to make skin keep solid and have elasticity.
Haematococcus pluvialis is the monoplast green alga in a kind of fresh water, can produce a large amount of carotenoids under given conditions
Element, wherein most are astaxanthin.The molecular structure of astaxanthin makes it with stronger inoxidizability.Stronger free radical is clear
Removing solid capacity makes astaxanthin play an important role the health of the mankind, can be effectively prevented each histoorgan of human body, thin
Born of the same parents, DNA etc. are aoxidized and caused damage, aging etc. and injure by oxygen radicals.
Cherry is rose department cherry genus plant, has long medicinal history in China.It is rich in anthocyanin in cherry juice, bears
The natural ingredient with health care function such as non-alcohol, gallic acid, Quercetin, perilla alcohol and melatonin.The pattern of cherry juice
Glycosides is the general name of a kind of water-soluble natural edible pigment, and multinomial research shows that cherry anthocyanin has stronger inoxidizability.
Pomegranate has more than 2000 years cultivation histories in China, and fruit is tasty, the big thin skin of fruit, and sweet juice is more.Stone
Antioxidant rich in pomegranate juice, such as polyphenol, tannin, ellagic acid, flavones and anthocyanidin.There is research clinical research hair
After now continuous 15 days daily intake 0.5L juice of my pomegranate, the glutathione for playing antioxidation in blood is significantly increased.
Protein glycosylation, i.e. Maillard reaction (Maillard Reaction), refer to amino-compound and carbonyl compound
A kind of chemical reaction between object, such reaction is normally present in food processing, tobacco development, Chinese medicine preparation, disease physiology waited
Cheng Zhong.Maillard reaction is influenced because being known as saccharide compound, amino-compound, temperature, moisture content, pH, oxidant etc..Work as temperature
When degree is greater than 30 DEG C, Mei Lade brown stain fast speed, and improved with temperature, reaction speed improves faster.In 10-15% moisture
Under conditions of content, Maillard reaction can occur.When the pH of reaction system is within the scope of 3-9, as pH rises, Mei Lade is anti-
Answer speed that can rise rapidly.Metal ion and oxygen can promote Maillard reaction.Maillard reaction can promote protein and ammonia
A large amount of losses of base acid, the black eutectic substance of the class ultimately generated cannot be absorbed by the body utilization, cause the waste of nutriment.
Collagen peptide amino acid rich in, and contain a large amount of glucides such as glucose in human body, it is these two types of
Substance is the basic role substance of Maillard reaction.The conditions such as temperature, moisture in human body, which meet, occurs wanting for Maillard reaction
It asks.Therefore after collagen peptide is taken by human body, Maillard reaction can occur with glucide in vivo, to make collagen
Peptide all effectively cannot be absorbed and be utilized by human body, reduce the physiological action of collagen peptide.
Haematococcus pluvialis contained in composition of the invention, cherry inspissated juice and pomegranate inspissated juice can not only play it
Respectively function in vivo, inventor also found that they can cooperate, consumption oxygen and reduction pH value, and prevention or buffering beauty
Intermediate reaction in Maillard reaction plays the role of reducing collagen peptide Maillard reaction, to promote the absorption of collagen
And effective use, so that the utilization rate for improving collagen reaches enhancing delay skin aging effect.And it is each through the invention
The adjusting of amounts of components, ensure that the maximization of collagen peptide dosage, and the minimum of other amounts of components, guarantee product function
While energy, reasonable control cost.
On the other hand, the embodiment of the invention also provides food or health care product comprising above-mentioned composition.
By mass percentage, in food containing 50% or more the present composition；Contain 50% or more in health care product
The present composition.
It should be noted that when preparing food or health care product using composition of the invention, in food or health care product also
Other function ingredient, such as Elastin peptide, tremella polysaccharides, chitosan oligosaccharide, yeast powder, juice or natural goods can be added
Extract of matter etc..
It, can be by existing preparation process, with acceptable carrier, diluent or corrigent for the ease of consumer's use
Deng combination, the health care product of oral preparation is made, optionally, the preparation type can be pulvis, pill, tablet, granule, glue
Wafer or liquid preparation.
For example, when the oral preparation be tablet when, preparation method include according to formula rate ingredient, mixed material,
Sieving and tabletting.
When the oral preparation is capsule, preparation method includes according to formula rate ingredient, mixing, encapsulated.
When the oral preparation is pulvis or granule, preparation method includes according to the mixing of formula rate ingredient, mistake
Sieve and packaging.
Further, for the ease of consumer's use, the food can be beverage or soft sweets.Those skilled in the art
Other food types comprising the composition can also be fabricated to, it is not further herein to be limited.
According to a specific embodiment, when for soft sweets, the preparation of the soft sweets include pre-treatment, sugar cook, mixing allotment,
Molding；When the oral preparation is beverage, the preparation method of the beverage includes according to formula rate ingredient, allotment, homogeneous, goes out
Bacterium, filling and pasteurization.
Embodiment 1
The present embodiment provides a kind of glycosylated beverage of reduction collagen peptide, the formula of the beverage is as shown in table 1.
A kind of 1 glycosylated drink formula of reduction collagen peptide of table
The beverage the preparation method is as follows:
According to formula rate shown in table 1, by collagen peptide, haematococcus pluvialis, cherry inspissated juice and pomegranate inspissated juice
After mixing homogeneous, be added other appropriate ingredients, for example, Elastin peptide, tremella polysaccharides, chitosan oligosaccharide, yeast powder, acidity regulator,
Sweetener and purified water, it is filling after mixing, then carry out high-temperature sterilization and can obtain finished product.
Embodiment 2
The present embodiment provides a kind of glycosylated beverage of reduction collagen peptide, the formula of the beverage is as shown in table 2.
A kind of 2 glycosylated drink formula of reduction collagen peptide of table
| Collagen peptide | 10000g |
| Haematococcus pluvialis | 10g |
| Cherry inspissated juice | 300g |
| Pomegranate inspissated juice | 700g |
The preparation method and embodiment 1 of the beverage are consistent.
Embodiment 3
The present embodiment provides a kind of glycosylated beverage of reduction collagen peptide, the formula of the beverage is as shown in the table.
A kind of 3 glycosylated drink formula of reduction collagen peptide of table
| Collagen peptide | 10000g |
| Haematococcus pluvialis | 15g |
| Cherry inspissated juice | 700g |
| Pomegranate inspissated juice | 300g |
The preparation method and embodiment 1 of the beverage are consistent.
Reference examples
The formula of a kind of beverage, the beverage is as shown in the table.
A kind of drink formula of table 4
The preparation method and embodiment 1 of the beverage are consistent.Comparative example 1
The formula of a kind of beverage, the beverage is as shown in the table.
A kind of drink formula of table 5
| Collagen peptide | 10000g |
| Haematococcus pluvialis | 50g |
The preparation method and embodiment 1 of the beverage are consistent.Comparative example 2
The formula of a kind of beverage, the beverage is as shown in the table.
A kind of drink formula of table 6
| Collagen peptide | 10000g |
| Haematococcus pluvialis | 500g |
The preparation method and embodiment 1 of the beverage are consistent.Comparative example 3
The formula of a kind of beverage, the beverage is as shown in the table.
A kind of drink formula of table 7
| Collagen peptide | 10000g |
| Cherry inspissated juice | 1000g |
The preparation method and embodiment 1 of the beverage are consistent.Comparative example 4
The formula of a kind of beverage, the beverage is as shown in the table.
A kind of drink formula of table 8
| Collagen peptide | 10000g |
| Cherry inspissated juice | 2000g |
The preparation method and embodiment 1 of the beverage are consistent.
Comparative example 5
The formula of a kind of beverage, the beverage is as shown in the table.
A kind of drink formula of table 9
| Collagen peptide | 10000g |
| Pomegranate inspissated juice | 1000g |
The preparation method and embodiment 1 of the beverage are consistent.
Comparative example 6
The formula of a kind of beverage, the beverage is as shown in the table.
A kind of drink formula of table 10
| Collagen peptide | 10000g |
| Pomegranate inspissated juice | 2000g |
The preparation method and embodiment 1 of the beverage are consistent.
Test example 1
The glycosylated effect of collagen peptide is reduced to verify the collaboration of the present composition, this test example has carried out as follows
Test:
This test be arranged reference examples group, example 1 group, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example, 2 groups of comparative example,
3 groups of comparative example, 4 groups of comparative example, 5 groups of comparative example, 6 groups of comparative example, totally 10 groups.
Reaction in analogue body:
In the phosphate buffer solution of the pH7.0 of 5000mL, the glucose of 6mmol/L is added, then solution is averaged
It is divided into 10 groups.Every group be separately added into reference examples, embodiment 1, embodiment 2, embodiment 3, comparative example 1, comparative example 2, comparative example 3,
Comparative example 4, comparative example 5, each 1mL of comparative example 6.Each solution is placed in 37 DEG C of water-baths and reacts 90min.It sets immediately after reaction
It is cooling in ice bath.5 secondary responses are carried out altogether makees Duplicate Samples.
Index determining:
The highest amino acid of content is glycine and proline in collagen peptide.Use sulfonic acid cation resin chromatography
The amino-acid analyzer of column measures glycine and proline content in sample respectively, and Detection wavelength is 570nm and 440nm.
It prepares kilnitamin standard working solution (100nmol/mL), is then infused respectively with same volume with each sample solution
Enter amino-acid analyzer, amino acid concentration in calculated by peak area sample solution is passed through with external standard method.
Data processing:
It is analyzed with SPSS19.0 statistical software, comparison among groups are examined using t, and P < 0.05 is that difference has statistics meaning
Justice.
It can be seen from Fig. 1 and Fig. 2 data compared with reference examples, embodiment 1, embodiment 2, embodiment 3 and each comparative example
Glycine and proline content it is significant higher (P < 0.01).Illustrate the raw Rhodococcus sp of rain, cherry inspissated juice and pomegranate inspissated juice
It can play the role of reducing collagen Maillard reaction.
Comparative example 1, without significant difference (P > 0.05), illustrates to improve the raw Rhodococcus sp usage amount of rain to glue compared with comparative example 2
The no remarkable effect of reduction of former protein peptides Maillard reaction.
Comparative example 3, without significant difference (P > 0.05), illustrates to improve cherry inspissated juice usage amount to glue compared with comparative example 4
The no remarkable effect of reduction of former protein peptides Maillard reaction.
There were significant differences compared with comparative example 5 for comparative example 6 (P < 0.05), illustrates that improving pomegranate inspissated juice usage amount can add
The reduction of collagen peptide Maillard reaction is acted on by force.Comparative example 6 and comparative example 1, comparative example 2, comparative example 3,4 phase of comparative example
Than there were significant differences (P < 0.05), illustrate that the pomegranate inspissated juice of high usage amount Rhodococcus sp more raw than rain and cherry inspissated juice have more
The significant effect for reducing collagen Maillard reaction.
Embodiment 1 compares no significant difference (P > 0.05) with embodiment 2 with embodiment 3.It is embodiment group and comparative example 1, right
Ratio 2, comparative example 3, comparative example 4 and comparative example 5 compare there were significant differences (P < 0.05), without significance difference compared with comparative example 6
Different (P > 0.05) illustrates that the proportion of embodiment group can reduce the raw Rhodococcus sp of rain, cherry inspissated juice and pomegranate inspissated juice usage amount
In the case where play the role of similar reducing collagen Maillard reaction with the pomegranate inspissated juice of high usage amount.Therefore implement
The proportion of example group is more excellent, more cost-effective compared to the pomegranate inspissated juice comparative example of high usage amount, and increases natural antioxygen in product
Compound source makes composition have more delay skin aging feature.
Test example 2
The effect of the delay skin agings such as the improvement moisture of skin for the verifying present composition, the present invention make following dynamic
Object test:
Experimental animal used in this test is SPF grades of rats, and 12 is more than the monthly age, and 180~220g of weight is purchased from Guangdong Province's medicine
Experimental Animal Center.
Blank control group, model control group, example 1 group, 2 groups of embodiment, 3 groups of embodiment, totally 5 groups is arranged in this test,
Each group given the test agent ingredient and dosage are as shown in the table.
11 given the test agent component list of table
Peroxidating animal model:
In addition to blank control group, remaining is organized other animal and is subcutaneously infused with D- galactolipin 40mg-1.2g/kg BW the nape of the neck
Modeling is penetrated or is injected intraperitoneally, injection volume 0.1mL/10g, one time a day, continuous modeling 6 weeks take blood to survey MDA, by MDA level point
Group is randomly divided into 1 model control group and 3 embodiment groups.
Administration:
The sample of 3 embodiment groups is concentrated into the same volume of suitable stomach-filling.Model control group gives same volume distillation
Water.4 groups in addition to blank group are continued to give same dose D- galactolipin the nape of the neck subcutaneously or abdominal cavity are infused while giving sample
It penetrates.
Index determining:
Experiment terminates to put to death animal；Measure moisture content of skin；Using hyaluronic acid ELISA kit, measure in skin thoroughly
Bright matter acid content.It is analyzed with SPSS19.0 statistical software, comparison among groups are examined using t, and P < 0.05 is that difference has statistics
Meaning.
12 each group skin water content of table and hyaluronic acid contents compare
Note: compared with blank control group, ★ P < 0.05；Compared with model group, ▲ P < 0.05
It can be seen from upper table data compared with blank control group, model control group rat skin water content and hyalomitome
Acid content significantly reduces (P < 0.05), illustrates that animal model is successful.
Compared with model control group, the rat skin water content and hyaluronic acid contents of 3 embodiments significantly increase (P <
0.05).This shows that the substance in embodiment group has a certain upgrade the effects of moisture content of skin and hyaluronic acid contents to rat.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention may be used also on the basis of the above description for those of ordinary skill in the art
To make other variations or changes in different ways, all embodiments can not be exhaustive here, it is all to belong to this hair
The obvious changes or variations that bright technical solution is extended out are still in the scope of protection of the present invention.
Claims (8)
1. a kind of glycosylated composition of reduction collagen peptide, which is characterized in that including following components: collagen peptide, rain
Raw haematococcus, cherry inspissated juice and pomegranate inspissated juice.
2. composition according to claim 1, which is characterized in that the amount of each component in the composition are as follows: collagen
3000-18000 parts of peptide, 5-50 parts of haematococcus pluvialis, 100-1000 parts of cherry inspissated juice and 100-1000 parts of pomegranate inspissated juice.
3. composition according to claim 2, which is characterized in that the amount of each component in the composition are as follows: collagen
5000-15000 parts of peptide, 5-30 parts of haematococcus pluvialis, 100-800 parts of cherry inspissated juice and 100-800 parts of pomegranate inspissated juice.
4. composition according to claim 2, which is characterized in that the amount of each component in the composition are as follows: collagen
6000-12000 parts of peptide, 5-20 parts of haematococcus pluvialis, 200-700 parts of cherry inspissated juice and 200-700 parts of pomegranate inspissated juice.
5. a kind of food, which is characterized in that include any glycosylated combination of reduction collagen peptide of claim 1-4
Object.
6. food according to claim 5, which is characterized in that by mass percentage, contain in the food or health care product
There is 50% or more the composition.
7. a kind of health care product, which is characterized in that any described glycosylated group of reduction collagen peptide comprising claim 1-4
Close object.
8. health care product according to claim 7, which is characterized in that by mass percentage, in the food or health care product
Contain 50% or more the composition.
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| IT202000032396A1 (en) * | 2020-12-24 | 2022-06-24 | Innobio S R L | COMBINATION COMPOSITION CONTAINING AN ACTIVE INGREDIENT DERIVED FROM ALGAE AND ITS USES IN THE MEDICAL AND NUTRITIONAL FIELDS |
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