CN109078174A - 一种防治牙龈癌的生物组合物 - Google Patents

一种防治牙龈癌的生物组合物 Download PDF

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CN109078174A
CN109078174A CN201811244941.4A CN201811244941A CN109078174A CN 109078174 A CN109078174 A CN 109078174A CN 201811244941 A CN201811244941 A CN 201811244941A CN 109078174 A CN109078174 A CN 109078174A
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曾严超
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Changsha Xiehaoji Biological Engineering Co Ltd
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Abstract

本发明涉及一种防治牙龈癌的生物组合物，其特征在于由以下重量份的原料制成：刺五加提取物6～8份、硫酸软骨素钠1～3份、沙苑子提取液7～9份、西兰花提取物8～10份、干酪乳杆菌2～5份、黑加仑油1～3份、金黄丝子提取物5～8份、黄芪提取物9～11份、岩白菜提取物9～11份、革兰氏阳性球菌3～6份、芹菜籽油3～6份、甜瓜蒂5～7份、余甘子提取物5～7份、茄子提取物1～3份、利莫那班1～3份、胶原多肽6～8份、蛇床子7～9份、土荆皮7～9份、木槿皮5～7份、放线菌5～7份。本发明使用经过严格筛选的动植物提取物粉末，接入菌种和离子水，进行厌氧发酵。发酵后保证了有益菌的活性，提高了药效、改变药性，使药效持久、疗效稳定。

Description

一种防治牙龈癌的生物组合物
技术领域
本发明属于生物医药技术领域，具体涉及一种防治牙龈癌的生物组合物。
背景技术
牙龈癌口腔颌面部恶性肿瘤牙龈溃疡,拔牙后伤口不愈,肿块,牙松动,疼痛口腔颌面部的恶性肿瘤以癌最常见，在癌瘤中又以鳞状细胞癌为最多见，在我国，口腔颌面部鳞癌多发生于40－60岁之间，男性多于女性，以牙龈癌、舌癌、颊癌、腭癌以及上颌窦癌常见，口腔癌在我国长江以北，占全身恶性肿瘤的1．45－5．6%，长江以南为1．75－5．18%。在印度其在全身恶性肿瘤中高达40%以上，牙龈癌在我国发生率较高，据上海交大医学院的统计资料，其在恶性肿瘤构成比中居首位，多为分化较高的鳞状细胞癌。
发明内容
本发明所要解决的技术问题在于针对上述现有技术中的不足，提供一种防治牙龈癌的生物组合物，该组合物利用了天然微生物发酵技术，使用经过严格筛选的动植物提取物粉末，接入菌种和离子水，进行厌氧发酵。发酵后保证了有益菌的活性，提高了药效、改变药性，使药效持久、疗效稳定。
所述的一种防治牙龈癌的生物组合物，其特征在于由以下重量份的原料制成：刺五加提取物6～8份、硫酸软骨素钠1～3份、沙苑子提取液7～9份、西兰花提取物8～10份、干酪乳杆菌2～5份、黑加仑油1～3份、金黄丝子提取物5～8份、黄芪提取物9～11份、岩白菜提取物9～11份、革兰氏阳性球菌3～6份、芹菜籽油3～6份、甜瓜蒂5～7份、余甘子提取物5～7份、茄子提取物 1～3份、利莫那班1～3份、胶原多肽6～8份、蛇床子7～9份、土荆皮7～9份、木槿皮5～7份、放线菌5～7份。
作为本发明的一种优选方案，其特征在于由以下重量份的原料制成：刺五加提取物6份、硫酸软骨素钠2份、沙苑子提取液9份、西兰花提取物8份、干酪乳杆菌4份、黑加仑油3份、金黄丝子提取物6份、黄芪提取物10份、岩白菜提取物11份、革兰氏阳性球菌4份、芹菜籽油5份、甜瓜蒂7份、余甘子提取物5份、茄子提取物2份、利莫那班3份、胶原多肽6份、蛇床子8份、土荆皮9份、木槿皮5份、放线菌6份。
上述的一种防治牙龈癌的生物组合物的制备方法为：按所述的重量份称取各原料，按重量份称取原料，放入搅拌发酵容器内，再按比例1:0.3加入离子水，均质搅拌均匀，使原料含水量在30%-40%，再将容器恒温在33°C～38°C，发酵100小时后烘干压片，即得防治牙龈癌的生物组合物。
上述一种防治牙龈癌的生物组合物的原料功效解析：
刺五加提取物：益气健脾，补肾安神，用于脾肾阳虚，体虚乏力，食欲不振，腰膝酸痛，失眠多梦，对中枢神经系统、抗疲劳、抗癌、增加机体的非特异性抵抗力、调节病理过程、抗衰老、对心血管系统、抗菌消炎、对内分泌系统、免疫增强作用。
硫酸软骨素钠：调节血脂、抗动脉硬化。
沙苑子提取液：补肝，益肾，明目，固精，治肝肾不足，腰膝酸痛，目昏，遗精早泄，小便频数，遗尿，尿血，白带。
西兰花提取物：具有抗癌、清除肺部细菌、防治痛风的功效，同时因为西兰花中各种其他营养成分，同时可以清除体内自由基、预防衰老、抗氧化的作用。
黑加仑油：预防和治疗动脉硬化、降低高血压、增进皮肤健康、促进女性荷尔蒙的自然生长，可协助糖尿病患者控制一些并发症。延缓衰老、增强皮肤弹性、调节人体生理机能、增强免疫力。
金黄丝子提取物：具有调节内分泌、调节心率和降血压的作用，延缓白内障形成。
黄芪提取物：黄芪提取物的抗肿瘤作用与增强机体免疫功能的作用有关，可改善机体肿瘤而致的免疫功能低下。
岩白菜提取物：具有止咳，抗炎症，对气管及肺组织呼吸影响。
芹菜籽油：散气、消肿、利尿、开通阻滞。
甜瓜蒂：具有保肝；抗癌；增强细胞免疫功能；抗炎和避孕；致吐。
余甘子提取物：余甘子所有的保健功能都与其清除自由基和抗氧化作用有关，是其药理和保健作用的基础，这一独特性质使其具有较高的食疗保健价值，防癌、抗衰老作用显著。
茄子提取物：清热凉血，消肿解毒，主治肠风下血，热毒疮痈，皮肤疮疡等病症。
利莫那班：能降血压、降胆固醇和降血糖。
胶原多肽：胶原多肽可与血小板反应后生产血纤维，再长大成血块，堵住伤口而止血，可使活化的细胞发挥功能，活化机能，提高人体免疫力，降血压和除血栓。
蛇床子：抗心律失常；抑制心脏；降血压；性激素样作用；抗真菌，杀虫、滴虫及杀精；祛痰和平喘；局部麻醉；抗变态反应，抗诱变作用；延缓衰老；影响血浆前列腺胞素和内环核苷酸的代谢；抑制平滑肌收缩；防治骨质疏松；有镇静催眠等作用。
土荆皮：具有抗真菌，抗生育，止血，对癌细胞活性有影响。
木槿皮：具有抑制肿瘤细胞生长作用。
有益效果：具有抗疲劳、抗癌、增加机体的非特异性抵抗力、堵住伤口而止血，可使活化的细胞发挥功能，活化机能，提高人体免疫力，抗菌消炎、对内分泌系统、增强免疫、提高抗癌药效，有镇静、镇惊、解热、降压，促进红血球新生等作用。
具体实施方式：
实施例一:
所述的一种防治牙龈癌的生物组合物，其特征在于由以下重量份的原料制成：刺五加提取物6份、硫酸软骨素钠1份、沙苑子提取液7份、西兰花提取物8份、干酪乳杆菌3份、黑加仑油1份、金黄丝子提取物6份、黄芪提取物9份、岩白菜提取物9份、革兰氏阳性球菌4份、芹菜籽油4份、甜瓜蒂5份、余甘子提取物5份、茄子提取物1份、利莫那班1份、胶原多肽6份、蛇床子7份、土荆皮7份、木槿皮5份、放线菌5份。
实施例二:
所述的一种防治牙龈癌的生物组合物，其特征在于由以下重量份的原料制成：刺五加提取物7份、硫酸软骨素钠2份、沙苑子提取液8份、西兰花提取物9份、干酪乳杆菌4份、黑加仑油2份、金黄丝子提取物7份、黄芪提取物10份、岩白菜提取物10份、革兰氏阳性球菌5份、芹菜籽油5份、甜瓜蒂6份、余甘子提取物6份、茄子提取物2份、利莫那班2份、胶原多肽7份、蛇床子8份、土荆皮8份、木槿皮6份、放线菌6份。
实施例三:
所述的一种防治牙龈癌的生物组合物，其特征在于由以下重量份的原料制成：刺五加提取物8份、硫酸软骨素钠3份、沙苑子提取液9份、西兰花提取物10份、干酪乳杆菌5份、黑加仑油3份、金黄丝子提取物8份、黄芪提取物11份、岩白菜提取物11份、革兰氏阳性球菌6份、芹菜籽油6份、甜瓜蒂7份、余甘子提取物7份、茄子提取物3份、利莫那班3份、胶原多肽8份、蛇床子9份、土荆皮9份、木槿皮7份、放线菌7份。
上述的一种防治牙龈癌的生物组合物的制备方法为：按所述的重量份称取各原料，按重量份称取原料，放入搅拌发酵容器内，再按比例1:0.3加入离子水，均质搅拌均匀，使原料含水量在30%-40%，再将容器恒温在33°C～38°C，发酵100小时后烘干压片，即得防治牙龈癌的生物组合物。
临床应用实例:
选取人群：2016年2月-2017年1月，依据就诊病历，在六所医院筛选牙龈癌患者140例，年龄32-76岁，平均年龄约为53岁，病程0.6-2.5年内，所有受试者均经X线双重对比造影、B超检查、癌胚抗原检测，诊断为牙龈癌。试验前，将患者随机分为两组，实验组70例和对照组70例，两组在年龄、病程、病情等方面无显著差异。实验组服用本发明实例一所得的一种防治牙龈癌的生物组合物，1天3次，每次15-20g，温热水吞服，45天为一个疗程；对照组使用其他常规药物。服药期间对两组患者进行连续观察，记录两组患者肿块大小、数量、位置、质地、活动度和有无压痛的变化情况；停药后持续观察半年，记录复发情况。
疗效判定标准：参照文献疗效标准，(1)显效：肿瘤病变全部消除，症状及体征消失，能维持六周以上；(2)有效：肿瘤病变基本消除，症状及体征明显改善，无新病情出现，能维持六周以上；(3)无效：症状及体征无改善，或出现新病情。
临床结果如下表：
总病例数 显效 有效 无效 有效率
实验组 70 34 31 5 92%
对照组 70 16 18 36 48%
从上表可以说明本发明所得产品疗效显著，可有效缓解病症，且服用本药物组合物均未出现任何毒副反应。

Claims (1)

1.一种防治牙龈癌的生物组合物，其特征在于由以下重量份的原料制成：刺五加提取物6～8份、硫酸软骨素钠1～3份、沙苑子提取液7～9份、西兰花提取物8～10份、干酪乳杆菌2～5份、黑加仑油1～3份、金黄丝子提取物5～8份、黄芪提取物9～11份、岩白菜提取物9～11份、革兰氏阳性球菌3～6份、芹菜籽油3～6份、甜瓜蒂5～7份、余甘子提取物5～7份、茄子提取物 1～3份、利莫那班1～3份、胶原多肽6～8份、蛇床子7～9份、土荆皮7～9份、木槿皮5～7份、放线菌5～7份。
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