CN109078120A - 一种中药组合物及应用 - Google Patents

一种中药组合物及应用 Download PDF

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Publication number
CN109078120A
CN109078120A CN201811340972.XA CN201811340972A CN109078120A CN 109078120 A CN109078120 A CN 109078120A CN 201811340972 A CN201811340972 A CN 201811340972A CN 109078120 A CN109078120 A CN 109078120A
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parts
radix
rhizoma
kidney
chinese medicine
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杨多旗
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Individual
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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Abstract

本发明提供一种中药组合物及应用，材料包括巴戟天、淫羊藿、锁阳、熟地、黄精、龟板、制首乌、山茱萸、白参、枸杞子、杜仲、补骨脂、菟丝子、当归、红花、茯苓、白术、菖蒲、远志、泽泻、麦冬、五味子、石斛、丹参、鹿角片、牛膝、金狗脊、牡丹皮、生地及延胡索；其中巴戟天、淫羊藿、锁阳、杜仲及菟丝子的质量占所有组合物质量百分比为15%~35%；熟地及龟板的质量占所有组合物质量百分比为10%~35%。本发明的有益效果在于以补肝肾为主，阴阳双调，以达到健身强腰，抵抗疲劳的功效，尤其是对于寒性体质的腰痛酸软、腰肌劳损和腰间盘突出的效果尤佳。

Description

一种中药组合物及应用
技术领域
本发明涉及中医药领域，具体涉及一种补肝肾、治疗腰椎疼痛的中药组合物及应用。
背景技术
腰椎间盘突出症当属中医“腰痛”、“腰痛连膝”、“肾亏”、 “痹证”等病症范畴， 肝肾亏虚 ,外感六淫 ,跌仆损伤 ,用力不当 ,皆可致气血瘀滞 ,经脉闭塞 ,阻滞不通 ,而发为本病。 由于肝肾亏虚而偏于阳虚 ,不能温养筋骨故临床以冷痛为主 ;肾主骨生髓 ,肾虚不能控制约束骨的正常结构与形态 ,使骨质变化 ,关节面软骨钙化 ,边缘唇样增生,形成不稳定关节;肝虚血不充 ,经筋失养而弛缓 ,弹性减小 ,甚则变性增厚 ,连络关节,约束骨骼功能失常 ,使椎体容易发生位移。这样在外力不当的情况下 ,很容易使椎间盘突出 ,压迫神经 ,产生腰腿痛， “腰者肾之府 ,转摇不能 ,肾将惫矣。”
在现有的补肾中药药物中，很少有针对腰间盘突出这一症状研发的配方。
发明内容
为解决上述技术问题，本发明提供一种中药组合物及应用。
具体技术方案如下：
一种中药组合物，其不同之处在于，原材料包括巴戟天、淫羊藿根、锁阳、熟地、黄精、龟板、制首乌、山茱萸、白参、枸杞子、杜仲、补骨脂、菟丝子、当归、红花、茯苓、白术、菖蒲、远志、泽泻、麦冬、五味子、石斛、丹参、鹿角片、牛膝、金狗脊、牡丹皮、生地及延胡索；其中巴戟天、淫羊藿根、锁阳、杜仲及菟丝子的质量占所有组合物质量百分比为15%~35%；熟地及龟板的质量占所有组合物质量百分比为10%~35%。
上述技术方案中，所述原材料还包括白术。
上述技术方案中，所述原材料的重量组分为：
巴戟天：2份~6份，淫羊藿根：2份~6份，锁阳：2份~6份，熟地：4份~10份，黄精：0.5份~3份，龟板：6份~15份，制首乌：0.5份~3份，山茱萸：1份~5份，白参：0.5份~3份，枸杞子：5份~10份，杜仲：3份~6份，补骨脂：0.5份~3份，菟丝子：2份~5份，当归：0.5份~4份，红花：0.5份~4份，茯苓：0.5份~3份，白术：0.5份~3.5份，菖蒲：0.5份~3.5份，远志：0.2份~3份，泽泻：0.2份~2份，麦冬：0.5份~3.5份，五味子：0.5份~2.5份，石斛：0.5份~3份，丹参：0.5份~4份，鹿角片：0.5份~4份，牛膝：0.5份~2.5份，金狗脊：0.5份~2.5份，牡丹皮：0.5份~3份，生地：0.5份~3份及延胡索：0.5份~3份。
上述技术方案中，所述原材料的重量组分为：
巴戟天：4.5份，淫羊藿根：4.5份，锁阳：4.5份，熟地：7份，黄精：1份，龟板：2份，制首乌：1份，山茱萸：3份，白参：2份，枸杞子：6份，杜仲： 5份，补骨脂：2份，菟丝子：4.5份，当归：1份，红花：1份，茯苓：1.5份，白术：0.8份，菖蒲：1.5份，远志：1份，泽泻：1份，麦冬：1份，五味子：1.2份，石斛：2份，丹参：2.5份，鹿角片：2份，牛膝：1份，金狗脊：1份，牡丹皮：1份，生地：2.5份及延胡索：2份。
上述中药组合物在制备药物制剂中的应用。
上述技术方案中，所述药物制剂的功效为补肝肾、强筋骨、治疗腰痛、治疗腰肌劳损或治疗腰间盘突出。
上述技术方案中，所述药物制剂为药酒。
与现有技术相比，本发明的有益效果在于以补肝肾为主，阴阳双调，以达到健身强腰，抵抗疲劳的功效，尤其是对于寒性体质的腰痛酸软、腰肌劳损和腰间盘突出的效果尤佳。
具体实施方式
下面结合实施例对本发明技术方案做详细说明。
巴戟天：味甘、辛，性微温，具有补肾阳，强筋骨，祛风湿之功效，常用于用于阳痿遗精，宫冷不孕，月经不调，少腹冷痛，风湿痹痛，筋骨痿软。
淫羊藿根：味辛、甘，性温，具有补肾助阳，祛风除湿之功效。常用于肾虚阳痿，小便淋沥，喘咳，风湿痹痛。
锁阳：味甘；性温，具有补肾阳，益精血，润肠通便之功效。常用于肾阳不足，精血亏虚，腰膝痿软，阳痿滑精，肠燥便秘。
杜仲：甘微辛，性温，功能主治为：补肝肾，强筋骨，安胎。治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，胎漏欲堕，胎动不安，高血压。①《本经》：主腰脊痛，补中益精气，坚筋骨，强志，除阴下痒湿，小便余沥。②《别录》：主脚中酸痛，不欲践地。③《药性论》：治肾冷臀腰痛，腰病人虚而身强直，风也。腰不利加而用之。④《日华子本草》：治肾劳，腰脊挛。入药炙用。⑤王好古：润肝燥，补肝经风虚。⑥《本草正》：止小水梦遗，暖子宫，安胎气。⑦《玉楸药解》：益肝肾，养筋骨，去关节湿淫。治腰膝酸痛，腿足拘挛。⑧《本草再新》：充筋力，强阳道。
菟丝子：味辛、甘，性平，具有补益肝肾，固精缩尿，安胎，明目，止泻之功效，外用具有消风祛斑之功效。常用于肝肾不足，腰膝酸软，阳痿遗精，遗尿尿频，肾虚胎漏，胎动不安，目昏耳鸣，脾肾虚泻；外治白癜风。
人参：性味味甘，微苦，性微温。归经为归肺，脾经。适于元气虚脱。补脾益肺：可治脾，肺气虚。用于津伤口渴，消渴。神增智：主治气血不足引起的心神不安，失眠健忘，常配养心安神药。此外，还可用治血虚，阳痿及正虚邪盛，均取本品气旺生血，气旺阳自强及扶正祛邪之功。
补骨脂：味苦辛、性温，用于补肾壮阳，固精缩尿，肾虚腰痛，小便频数，小儿遗尿，肾漏，温脾止泻，纳气平喘。
鹿角片：味咸气温，具有补肾阳、益精血、强筋骨、行血消肿等功效，主治肾虚腰脊冷痛、阳痿遗精、崩漏、白带、尿频尿多、阴疽疮疡、乳痈肿痛、跌打瘀肿、筋骨疼痛等症状。
熟地：甘，微温。具有补血滋阴功效，可用于血虚萎黄，眩晕，心悸失眠，月经不调，崩漏等症，亦可用于肾阴不足的潮热骨蒸、盗汗、遗精、消渴等症。
黄精：味甘，性平，用于脾胃气虚，体倦乏力，胃阴不足，口干食少，肺虚燥咳，劳嗽咳血，精血不足，腰膝酸软，须发早白，内热消渴。
龟板：味咸甘，性平，治肾阴不足，骨蒸劳热，吐血，衄血，久咳，遗精，崩漏，带下，腰痛，骨痿， 阴虚风动，久痢，久疟，痔疮，小儿囟门不合。
制首乌：气微，味微甘而苦涩，补肝肾，益精血，乌须发，强筋骨，化浊降脂。用于血虚萎黄，眩晕耳呜，须发早白，腰膝酸软，肢体麻木，崩漏带下，高脂血症。
山茱萸：味酸、涩，性微温，具有补益肝肾，收涩固脱之功效。常用于眩晕耳鸣，腰膝酸痛，阳痿遗精，遗尿尿频，崩漏带下，大汗虚脱，内热消渴。
枸杞子：味甘性平，功能主治为：滋肾，润肺，补肝，明目。治肝肾阴亏，腰膝酸软，头晕，目眩，目昏多泪，虚劳咳嗽，消渴，遗精。
当归：味甘、辛，性温，具有补血活血，调经止痛，润肠通便之功效。常用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，风湿痹痛，跌扑损伤，痈疽疮疡，肠燥便秘。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。
红花：味辛，性温，具有活血通经，散瘀止痛之功效。用于经闭，痛经，恶露不行，症瘕痞块，胸痹心痛，瘀滞腹痛，胸胁刺痛，跌扑损伤，疮疡肿痛。
茯苓：味甘、淡，性平，用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
白术：味苦，甘，性温，健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。土白术健脾，和胃，安胎。用于脾虚食少，泄泻便溏，胎动不安。
菖蒲：味苦、辛，性温。化痰，开窍，健脾，利湿。用于癫痫，惊悸健忘，神志不清，湿滞痞胀，泄泻痢疾，风湿疼痛，痈肿疥疮。
远志：味苦、辛、性温，具有安神益智、祛痰、消肿的功能，用于心肾不交引起的失眠多梦、健忘惊悸，神志恍惚，咳痰不爽，疮疡肿毒，乳房肿痛。
泽泻：味甘，性寒，主治肾炎水肿、肾盂肾炎、肠炎泄泻、小便不利等症。
麦冬: 味甘，微苦，微寒。归心、肺、胃经。养阴生津，润肺止咳：用于肺胃阴虚之津少口渴、干咳咯血；心阴不足之心悸易惊及热病后期热伤津液等证。配沙参、川贝可治肺阴虚干咳。
五味子：味酸、甘，性温。归肺、心、肾经。用于久嗽虚喘，梦遗滑精，遗尿尿频，久泻不止，自汗盗汗，津伤口渴，内热消渴，心悸失眠。
石斛：味甘，性微寒。归胃、肾经。具有益胃生津，滋阴清热之功效。常用于热病津伤，口干烦渴，胃阴不足，食少干呕，病后虚热不退，阴虚火旺，骨蒸劳热，目暗不明，筋骨痿软。
丹参：味苦，微寒。归心、肝经。具有活血祛瘀，通经止痛，清心除烦，凉血消痈之功效。用于胸痹心痛，脘腹胁痛，瘕瘕积聚，热痹疼痛，心烦不眠，月经不调，痛经经闭，疮疡肿痛。
牛膝：味苦、甘、酸，性平。归肝、肾经。用于经闭，痛经，腰膝酸痛，筋骨无力，淋证，水肿，头痛，眩晕，牙痛，日疮，吐血，衄血。
金狗脊：为苦、甘，性温。归肝、肾经。祛风湿，补肝肾，强腰膝。风湿痹痛，腰膝酸软，下肢无力，尿频，遗尿，白带过多。外敷金疮止血。腰背强，关机缓急，周痹寒湿膝痛，颇利老人。男子女人毒风软脚，肾气虚弱，续筋骨，补益男子。强肝肾，健骨，治风虚。
牡丹皮：味苦、辛，性微寒。归心、肝、肾经。热入营血，温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，跌扑伤痛，痈肿疮毒。
生地：味甘，性寒。归心，肝，肾经。清热凉血，养阴，生津。用于热病舌绛烦渴，阴虚内热，骨蒸劳热，内热消渴，吐血，衄血，发斑发疹。
延胡索：味辛、苦，性温。归肝、脾经。具有活血，行气，止痛的功效。用于胸胁、脘腹疼痛，胸痹心痛，经闭痛经，产后瘀阻，跌扑肿痛。
方解：本发明以巴戟天、淫羊藿、锁阳、杜仲、菟丝子补阳重用为君，人参、补骨脂、鹿角片助阳为臣，熟地、龟板滋阴重用为君，黄精、制首乌、山茱萸助阴为臣，枸杞子阴阳双补为臣，佐以五味子、石斛及麦冬育阴培阳，菖蒲、远志、泽泻、茯苓及丹皮化浊开窍，泄为补用，丹参、红花、当归、延胡索、生地黄及丹皮用以活血、凉血、止痛，金狗脊及牛膝用以补肝肾，加之白术健脾。本方以补肝肾为主，阴阳双调，恢复自身功能，以达健身强腰，常用可抗疲劳。
实施例一
补肾健腰酒的制备
将原料按一定的重量份数进行配置后泡入酒中，具体原料及份数如下：
巴戟天：4.5份，淫羊藿：4.5份，锁阳：4.5份，熟地：7份，黄精：1份，龟板：10份，制首乌：1份，山茱萸：3份，人参：2份，枸杞子：6份，杜仲： 5份，补骨脂：2份，菟丝子：4.5份，当归：1份，红花：1份，茯苓：1.5份，白术：0.8份，菖蒲：1.5份，远志：1份，泽泻：1份，麦冬：1份，五味子：1.2份，石斛：2份，丹参：2.5份，鹿角片：2份，牛膝：1份，金狗脊：1份，牡丹皮：1份，生地：2.5份及延胡索：2份。
应用例：
胡某，40岁，凉菜师傅，性别女，L3~L4、L4~L5腰间盘突出，腰痛直不起腰，服用药酒三个疗程后，三个疗程后，病痛减轻至消失，后期服用加强疗效直至完全康复。
实施例2
将原料按一定的重量份数进行配置后进行熬制，以现代工艺制成冲服颗粒。
巴戟天：5份，淫羊藿：5份，锁阳：5份，熟地：8份，黄精：1.5份，龟板：9份，制首乌：2份，山茱萸：2份，人参：1.5份，枸杞子：7份，杜仲：3份，补骨脂：2份，菟丝子：4份，当归：2份，红花：1份，茯苓：0.5份，白术：1份，菖蒲：0.8份，远志：1份，泽泻：0.5份，麦冬：1.2份，五味子：1.2份，石斛：2份，丹参：2份，鹿角片：2.5份，牛膝：1份，金狗脊：1.2份，牡丹皮：1份，生地：2份及延胡索1.5份。
应用例：
李某，男，70岁，农民，因腰间盘突出腰痛久治不愈，服药5个疗程后疼痛明显减轻，身体好转。
必须说明的是，以上所述实施例只是本发明的一些实施方式。对于本领域的技术人员来说，在不脱离本发明创造构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。

Claims (7)

1.一种中药组合物，其特征在于，原材料包括巴戟天、淫羊藿、锁阳、熟地、黄精、龟板、制首乌、山茱萸、白参、枸杞子、杜仲、补骨脂、菟丝子、当归、红花、茯苓、白术、菖蒲、远志、泽泻、麦冬、五味子、石斛、丹参、鹿角片、牛膝、金狗脊、牡丹皮、生地及延胡索；其中巴戟天、淫羊藿、锁阳、杜仲及菟丝子的质量占所有组合物质量百分比为15%~35%；熟地及龟板的质量占所有组合物质量百分比为10%~35%。
2.根据权利要求1所述一种中药组合物，其特征在于，所述原材料还包括白术。
3.根据权利要求2所述一种中药组合物，其特征在于，所述原材料的重量组分为：
巴戟天：2份~6份，淫羊藿：2份~6份，锁阳：2份~6份，熟地：4份~10份，黄精：0.5份~3份，龟板：6份~15份，制首乌：0.5份~3份，山茱萸：1份~5份，白参：0.5份~3份，枸杞子：5份~10份，杜仲：3份~6份，补骨脂：0.5份~3份，菟丝子：2份~5份，当归：0.5份~4份，红花：0.5份~4份，茯苓：0.5份~3份，白术：0.5份~3.5份，菖蒲：0.5份~3.5份，远志：0.2份~3份，泽泻：0.2份~2份，麦冬：0.5份~3.5份，五味子：0.5份~2.5份，石斛：0.5份~3份，丹参：0.5份~4份，鹿角片：0.5份~4份，牛膝：0.5份~2.5份，金狗脊：0.5份~2.5份，牡丹皮：0.5份~3份，生地：0.5份~3份及延胡索：0.5份~3份。
4.根据权利要求2所述一种中药组合物，其特征在于，所述原材料的重量组分为：
巴戟天：4.5份，淫羊藿：4.5份，锁阳：4.5份，熟地：7份，黄精：1份，龟板：10份，制首乌：1份，山茱萸：3份，白参：2份，枸杞子：6份，杜仲： 5份，补骨脂：2份，菟丝子：4.5份，当归：1份，红花：1份，茯苓：1.5份，白术：0.8份，菖蒲：1.5份，远志：1份，泽泻：1份，麦冬：1份，五味子：1.2份，石斛：2份，丹参：2.5份，鹿角片：2份，牛膝：1份，金狗脊：1份，牡丹皮：1份，生地：2.5份及延胡索：2份。
5.权利要求1~4任一项所述中药组合物在制备药物制剂中的应用。
6.根据权利要求5所述的应用，所述药物制剂的功效为补肝肾、强筋骨、治疗腰痛、治疗腰肌劳损或治疗腰间盘突出。
7.根据权利要求5所述的应用，所述药物制剂为药酒。
CN201811340972.XA 2018-11-12 2018-11-12 一种中药组合物及应用 Pending CN109078120A (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116889613A (zh) * 2023-07-27 2023-10-17 中天洞庭生物制药有限公司 一种具有改善身体素质功能的组合物及其制备方法
CN117771334A (zh) * 2024-02-26 2024-03-29 天津源盛医疗科技有限公司 调节自噬并抗乳腺肿瘤和结节的中药组合物及其制备方法和应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116889613A (zh) * 2023-07-27 2023-10-17 中天洞庭生物制药有限公司 一种具有改善身体素质功能的组合物及其制备方法
CN117771334A (zh) * 2024-02-26 2024-03-29 天津源盛医疗科技有限公司 调节自噬并抗乳腺肿瘤和结节的中药组合物及其制备方法和应用
CN117771334B (zh) * 2024-02-26 2024-05-07 天津源盛医疗科技有限公司 调节自噬并抗乳腺肿瘤和结节的中药组合物及其制备方法和应用

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