CN109071483A - Penicilones 衍生物及其作为抗耐药菌药物的应用 - Google Patents

Penicilones 衍生物及其作为抗耐药菌药物的应用 Download PDF

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Publication number
CN109071483A
CN109071483A CN201880001533.8A CN201880001533A CN109071483A CN 109071483 A CN109071483 A CN 109071483A CN 201880001533 A CN201880001533 A CN 201880001533A CN 109071483 A CN109071483 A CN 109071483A
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compound
formulas
approach
formula
base
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CN109071483B (zh
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陈敏
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Yangzhou Blue Biomedical Technology Co ltd
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Yangzhou Blue Biomedical Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种penicilones衍生物及其作为抗耐药菌药物的应用，具体涉及一种式I化合物、其立体异构体、其互变异构体、其溶剂化物、其前药、其药学上可接受的盐或其盐的溶剂化物，其特征在于式I化合物具有如下结构：

Description

PCT国内申请，说明书已公开。

Claims (36)

  1. PCT国内申请，权利要求书已公开。
CN201880001533.8A 2017-02-04 2018-02-02 Penicilones衍生物及其作为抗耐药菌药物的应用 Active CN109071483B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710065001.8 2017-02-04
CN201710065001 2017-02-04
PCT/CN2018/075069 WO2018141263A1 (zh) 2017-02-04 2018-02-02 Penicilones衍生物及其作为抗耐药菌药物的应用

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CN109071483A true CN109071483A (zh) 2018-12-21
CN109071483B CN109071483B (zh) 2023-02-28

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CN (1) CN109071483B (zh)
WO (1) WO2018141263A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108503585A (zh) * 2017-02-28 2018-09-07 扬州蓝色生物医药科技有限公司 PeniciloneB的氨基酸衍生物及其作为抗菌药物的应用
CN114774158A (zh) * 2022-02-17 2022-07-22 贵州民族大学 芳香性聚氨基酸低温破乳剂的制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110003158B (zh) * 2019-04-12 2022-10-28 安徽农业大学 一种黄绿木霉菌的代谢产物和应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859027A (en) * 1996-02-26 1999-01-12 Chektec Corporation Antimicrobial agent
JP2005220040A (ja) * 2004-02-03 2005-08-18 Ajinomoto Co Inc 新規抗真菌物質ｆａ２００ｂ
CN103910708B (zh) * 2014-02-28 2016-04-20 中山大学 一种海洋真菌来源的Azaphilones化合物及其制备方法和应用
CN104311525A (zh) * 2014-09-13 2015-01-28 中山大学 海洋真菌来源的Azaphilone类化合物在制备抗结核药物中的应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COLUMBUS, OHIO, US: "CHEMICAL ABSTRACTS SERVICE. Retrieved from STN International，Columbus，USA. AN：111:545. 摘要", 《DATABASE REGISTRY [ONLINE]》 *
DANG NGOC QUANG等: "Cohaerins C–F, four azaphilones from the xylariaceous fungus Annulohypoxylon cohaerens", 《TETRAHEDRON》 *
LONG LIN等: "Synthesis and Antifungal Activity of Novel Sclerotiorin Analogues", 《JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108503585A (zh) * 2017-02-28 2018-09-07 扬州蓝色生物医药科技有限公司 PeniciloneB的氨基酸衍生物及其作为抗菌药物的应用
CN108503585B (zh) * 2017-02-28 2019-10-25 扬州蓝色生物医药科技有限公司 Penicilone B的氨基酸衍生物及其作为抗菌药物的应用
CN114774158A (zh) * 2022-02-17 2022-07-22 贵州民族大学 芳香性聚氨基酸低温破乳剂的制备方法
CN114774158B (zh) * 2022-02-17 2023-08-11 贵州民族大学 芳香性聚氨基酸低温破乳剂的制备方法

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WO2018141263A1 (zh) 2018-08-09
CN109071483B (zh) 2023-02-28

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