CN109071483A - Penicilones 衍生物及其作为抗耐药菌药物的应用 - Google Patents
Penicilones 衍生物及其作为抗耐药菌药物的应用 Download PDFInfo
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- CN109071483A CN109071483A CN201880001533.8A CN201880001533A CN109071483A CN 109071483 A CN109071483 A CN 109071483A CN 201880001533 A CN201880001533 A CN 201880001533A CN 109071483 A CN109071483 A CN 109071483A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Communicable Diseases (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及一种penicilones衍生物及其作为抗耐药菌药物的应用,具体涉及一种式I化合物、其立体异构体、其互变异构体、其溶剂化物、其前药、其药学上可接受的盐或其盐的溶剂化物,其特征在于式I化合物具有如下结构:
Description
PCT国内申请,说明书已公开。
Claims (36)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710065001 | 2017-02-04 | ||
CN201710065001.8 | 2017-02-04 | ||
PCT/CN2018/075069 WO2018141263A1 (zh) | 2017-02-04 | 2018-02-02 | Penicilones衍生物及其作为抗耐药菌药物的应用 |
Publications (2)
Publication Number | Publication Date |
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CN109071483A true CN109071483A (zh) | 2018-12-21 |
CN109071483B CN109071483B (zh) | 2023-02-28 |
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ID=63040270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201880001533.8A Active CN109071483B (zh) | 2017-02-04 | 2018-02-02 | Penicilones衍生物及其作为抗耐药菌药物的应用 |
Country Status (2)
Country | Link |
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CN (1) | CN109071483B (zh) |
WO (1) | WO2018141263A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108503585A (zh) * | 2017-02-28 | 2018-09-07 | 扬州蓝色生物医药科技有限公司 | PeniciloneB的氨基酸衍生物及其作为抗菌药物的应用 |
CN114774158A (zh) * | 2022-02-17 | 2022-07-22 | 贵州民族大学 | 芳香性聚氨基酸低温破乳剂的制备方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110003158B (zh) * | 2019-04-12 | 2022-10-28 | 安徽农业大学 | 一种黄绿木霉菌的代谢产物和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859027A (en) * | 1996-02-26 | 1999-01-12 | Chektec Corporation | Antimicrobial agent |
JP2005220040A (ja) * | 2004-02-03 | 2005-08-18 | Ajinomoto Co Inc | 新規抗真菌物質fa200b |
CN103910708B (zh) * | 2014-02-28 | 2016-04-20 | 中山大学 | 一种海洋真菌来源的Azaphilones化合物及其制备方法和应用 |
CN104311525A (zh) * | 2014-09-13 | 2015-01-28 | 中山大学 | 海洋真菌来源的Azaphilone类化合物在制备抗结核药物中的应用 |
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2018
- 2018-02-02 WO PCT/CN2018/075069 patent/WO2018141263A1/zh active Application Filing
- 2018-02-02 CN CN201880001533.8A patent/CN109071483B/zh active Active
Non-Patent Citations (3)
Title |
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COLUMBUS, OHIO, US: "CHEMICAL ABSTRACTS SERVICE. Retrieved from STN International,Columbus,USA. AN:111:545. 摘要", 《DATABASE REGISTRY [ONLINE]》 * |
DANG NGOC QUANG等: "Cohaerins C–F, four azaphilones from the xylariaceous fungus Annulohypoxylon cohaerens", 《TETRAHEDRON》 * |
LONG LIN等: "Synthesis and Antifungal Activity of Novel Sclerotiorin Analogues", 《JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108503585A (zh) * | 2017-02-28 | 2018-09-07 | 扬州蓝色生物医药科技有限公司 | PeniciloneB的氨基酸衍生物及其作为抗菌药物的应用 |
CN108503585B (zh) * | 2017-02-28 | 2019-10-25 | 扬州蓝色生物医药科技有限公司 | Penicilone B的氨基酸衍生物及其作为抗菌药物的应用 |
CN114774158A (zh) * | 2022-02-17 | 2022-07-22 | 贵州民族大学 | 芳香性聚氨基酸低温破乳剂的制备方法 |
CN114774158B (zh) * | 2022-02-17 | 2023-08-11 | 贵州民族大学 | 芳香性聚氨基酸低温破乳剂的制备方法 |
Also Published As
Publication number | Publication date |
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CN109071483B (zh) | 2023-02-28 |
WO2018141263A1 (zh) | 2018-08-09 |
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