CN109045251A - A kind of external application improves composition and its application of microcirculation - Google Patents
A kind of external application improves composition and its application of microcirculation Download PDFInfo
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- CN109045251A CN109045251A CN201810854697.7A CN201810854697A CN109045251A CN 109045251 A CN109045251 A CN 109045251A CN 201810854697 A CN201810854697 A CN 201810854697A CN 109045251 A CN109045251 A CN 109045251A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61F7/02—Compresses or poultices for effecting heating or cooling
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
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- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
- A61F2007/0263—Compresses or poultices for effecting heating or cooling medicated made of a substance with therapeutic action, e.g. copper or silver
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Abstract
The invention discloses compositions and reason application that a kind of external application improves microcirculation, and the composition that the external application improves microcirculation composition includes nanoscale Tourmaline powder, piperine, capsaicine, vanillyl alcohol butyl ether, oil of ginger, garlic oil, menthol, Japan pepper essential oil.Clinical trial shows, there are apparent Microcirculation of Nailfold obstacles by subject before being applied using reason, items integral increases, and integrating after using microcirculation reason application reduces, and performance outlet pipe loop number increases, pipe loop length increases, branch thickening is inputted, color reddens, and flow velocity is accelerated, lopsided pipe loop number reduction etc., can significantly improve the Microcirculation of Nailfold of subject.Microcirculation of Nailfold is detected as microcirculation reason application, and effect is dialectical provides the index of objective quantitative, and has preferable improvement, and further relating to microcirculation reason application has effects that improve blood circulation of human body to relieve pain.
Description
Technical field
The invention belongs to Traditional Chinese health technical fields, and in particular to a kind of external application improves the composition of microcirculation and reason is applied
Patch.
Background technique
Hot compress paste, also known as heating paste, reaction principle are to be sent out under the action of skin microstimulation using exothermic material
Thermal response is to generate heat.The lasting heat release of hot compress paste can promote microcirculation in human body to enter benign recurrent state, restore just
Normal physiological function treats disease to eliminate pain.
Currently, hot compress paste in the market has the following problems: being not easily controlled temperature when use, skin is be easy to cause to scald
Wound, and the heat production time is shorter, cannot generate lasting heating effect, so that preferable health-care effect be not achieved.In addition, existing
Hot compress paste there are drug effects poor, narrow application range, slow effect, the problems such as short time can only improving symptom.
Summary of the invention
Improve the composition of microcirculation the purpose of the present invention is to provide a kind external application and the especially reason that is prepared is applied
Patch
The technical solution used in the present invention is:
A kind of external application improves the composition of microcirculation, and composition includes nano-scale far infrared ceramic powder, nanoscale Tourmaline powder, Hu
Green pepper alkali, capsaicine, vanillyl alcohol butyl ether, oil of ginger, garlic oil, menthol, Japan pepper essential oil.
Preferably, the composition that the external application improves microcirculation composition includes nano-scale far infrared ceramic powder 20-
30 parts, 10-20 parts of nanoscale Tourmaline powder, 5-10 parts of piperine, 10-15 parts of capsaicine, 5-10 parts of vanillyl alcohol butyl ether, oil of ginger
10-20 parts, 10-20 parts of garlic oil, 5-10 parts of menthol, 10-20 parts of Japan pepper essential oil, by weight.
A kind of external application improves the reason application of microcirculation comprising hypothallus, heating layer and surface covering, on the heating layer
The external application stated improves microcirculation composition and is made.
Preferably, the preparation of the hypothallus includes the following steps:
(1) by weight, silica gel 25-40 parts of selection, it is 10-30 parts of rubber, 1-10 parts of latex, 0.8-1.5 parts of hexadecanol, stearic
Sour zinc 0.3-1 parts, 25-55 parts of polyvinyl chloride, the heating of colloidal sol pot is added and is mixed and stirred for uniformly；
(2) raw material after mixing evenly is continued to be heated to 120-140 DEG C in colloidal sol pot；
(3) organic sulfurizing agent is added in the mixture in step (2) and high saturation naphthenic base plasticizer mixes, make silicon rubber point
Son crosslinks sulfurization and plasticization at high temperature；
(4) composition in step (3) is poured into mold.
Preferably, the preparation of the heating layer includes the following steps:
(1) composition for choosing external application improvement microcirculation of any of claims 1 or 2 is uniformly mixed；
(2) mixture of step (1) is sufficiently mixed with hypothallus at 110-130 DEG C；
(3) it suppresses and is cooled and shaped in a mold to the composition in step (2), form silicone rubber plate.
Preferably, the production method of the surface covering are as follows: by the hydrosol and hot melt adhesive even application in silicon rubber
On piece is attached with self-adhesive paper.
The beneficial effects of the present invention are:
Managing application the present invention is based on microcirculation improves the observation analysis that Nail Fold Microcirculation ring status carries out test group and control group, as a result
Show test group case 180, is effectively improved 140 (20 sleep improvements, 120 different degrees of pain improve), always has
Efficiency 77.77%；Control group effective percentage is 10%.Experimental group total mark value take front and back from 2.392 ± 0.934 to 0.823 ±
0.438, and there is significant difference (P < 0. 01) through statistical analysis.There are apparent nail folds by subject before being applied using reason
Microcirculation disorder, items integral increase, and integrating after using microcirculation reason application reduces, and performance outlet pipe loop number increases
Add, pipe loop length increases, and inputs branch thickening, and color reddens, and flow velocity is accelerated, and lopsided pipe loop number is reduced etc., can significantly improve by
The Microcirculation of Nailfold of examination person.Microcirculation of Nailfold is detected as that microcirculation reason application effect is dialectical to provide the index of objective quantitative, and
There is preferable improvement, further relating to microcirculation reason application has effects that improve blood circulation of human body to relieve pain.
Specific embodiment
Medicinal material used in following embodiment can be commercially available from China Medicament Group Corp., meet People's Republic of China's medicine
2005 editions standards of allusion quotation.Other raw materials can be obtained by commercially available purchase.
Embodiment 1
A kind of external application improvement microcirculation composition, composition include 25 parts of nano-scale far infrared ceramic powder, nanoscale Tourmaline powder
15 parts, 5 parts of piperine, 15 parts of capsaicine, 5 parts of vanillyl alcohol butyl ether, 15 parts of oil of ginger, 20 parts of garlic oil, 5 parts of menthol, pepper essence
15 parts of oil, by weight.
A kind of external application improves the preparation method for managing application of microcirculation, includes the following steps:
1, hypothallus makes
(1) 25 parts of environment-friendly silica gel of selection, 20 parts of environment-friendly rubber, 5 parts of environmentally friendly latex, 1 part of hexadecanol, 0.5 part of zinc stearate, polychlorostyrene
48.5 parts of ethylene, the heating of colloidal sol pot is added and is mixed and stirred for uniformly；
(2) raw material after mixing evenly is continued to be heated to 120-140 DEG C in colloidal sol pot；
(3) organic sulfurizing agent is added in the mixture in step (2) and high saturation naphthenic base plasticizer mixes, make silicon rubber point
Son crosslinks sulfurization and plasticization at high temperature, improves the physical properties such as the intensity, elasticity, plasticity of hypothallus,
Reduce its hardness；
(4) composition in step (3) is poured into mold.
2, heating layer makes
(1) above-mentioned external application improvement microcirculation composition is uniformly mixed；
(2) hypothallus temperature is controlled to about 120 DEG C, the mixture of step (1) is sufficiently fused in hypothallus；
(3) it suppresses and is cooled and shaped in a mold to the composition in step (2), form silicone rubber plate.
3, surface covering makes: by the hydrosol and hot melt adhesive even application on silicone rubber plate, being attached with self-adhesive paper.
Embodiment 2
A kind of external application improvement microcirculation composition, composition include 20 parts of nano-scale far infrared ceramic powder, nanoscale Tourmaline powder
10 parts, 10 parts of piperine, 10 parts of capsaicine, 10 parts of vanillyl alcohol butyl ether, 20 parts of oil of ginger, 10 parts of garlic oil, 10 parts of menthol, Chinese prickly ash
10 parts of essential oil, by weight.
Above-mentioned external application improvement microcirculation composition is prepared into reason application, steps are as follows:
1, hypothallus makes
(1) 40 parts of environment-friendly silica gel of selection, 15 parts of environment-friendly rubber, 10 parts of environmentally friendly latex, 1.5 parts of hexadecanol, 1.0 parts of zinc stearate,
32.5 parts of polyvinyl chloride, the heating of colloidal sol pot is added and is mixed and stirred for uniformly；
(2) raw material after mixing evenly is continued to be heated to 120-140 DEG C in colloidal sol pot；
(3) organic sulfurizing agent is added in the mixture in step (2) and high saturation naphthenic base plasticizer mixes, make silicon rubber point
Son crosslinks sulfurization and plasticization at high temperature, improves the physical properties such as the intensity, elasticity, plasticity of hypothallus,
Reduce its hardness；
(4) composition in step (3) is poured into mold.
2, heating layer makes
(1) above-mentioned external application improvement microcirculation composition is uniformly mixed；
(2) hypothallus temperature is controlled to about 120 DEG C, the mixture of step (1) is sufficiently fused in hypothallus；
(3) it suppresses and is cooled and shaped in a mold to the composition in step (2), form silicone rubber plate.
3, surface covering makes: by the hydrosol and hot melt adhesive even application on silicone rubber plate, being attached with self-adhesive paper.
Embodiment 3
A kind of external application improvement microcirculation composition, composition include 30 parts of nano-scale far infrared ceramic powder, nanoscale Tourmaline powder
20 parts, 5 parts of piperine, 10 parts of capsaicine, 5 parts of vanillyl alcohol butyl ether, 10 parts of oil of ginger, 15 parts of garlic oil, 10 parts of menthol, pepper essence
20 parts of oil, by weight.
Above-mentioned external application improvement microcirculation composition is prepared into reason application, step is as described in Example 1.
4 clinical trial of embodiment
The external application that testing example 1 is prepared improves improvement of the reason application to volunteer's Microcirculation of Nailfold of microcirculation.
1 test apparatus: microcirculation tester, model are produced using view optical valley optical instrument Co., Ltd deeply of Shenzhen
SGO-XW8000。
2 subjects
Experience subject 200, women, the oldest person are 45 years old, reckling 16 years old, average out to 30.5 years old.Due to physiology
Primary mild or moderate pain 200 caused by phase.And divide level Four with pain degree staging (VRS method)；0 grade (n=3, normal):
Without pain, I grades (n=80, slight) can endure, and life is normal, sleeps noiseless, II grades of (n=100, moderate) pain are obvious, cannot
It endures, it is desirable that take analgesic, sleep interference；III level (n=17, severe) sharp ache, cannot recognize, need to take analgesia
Drug, sleep can be with autonomic nervous dysfunction or passive positions by severe jamming.
3 methods
By Microcirculation of Nailfold clinical routine, the distal end first row capillary conduct of subject's left hand third finger nail fold is observed
Sighting tube loop form (clarity, pipe loop number, inlet branch diameter, output branch caliber, loop diameter diameter, pipe loop length, cross pipe loop number,
Lopsided pipe loop number), fluidised form (flow velocity, vasomotor, erythrocyte aggregation, leukocyte count, Bai Weishuan, color), loop week state (
Veniplex, nipple, sudoriferous duct under exudation, bleeding, nipple) etc. 20 indexs.With field ox Microcirculation of Nailfold weighted and integral method
It carries out comprehensive score and calculates score value.
4 statistical procedures
Measurement data uses mean, and standard deviation indicates, analyzes using SPSS11.5 statistical software and EXCEL software, P < 0. 01
There is significant for statistical difference.
5 results
5.1 Microcirculation of Nailfold testing results
It is detected in 200 subjects through Microcirculation of Nailfold, wherein Indexes Abnormality person accounts for the 19% of total detection number of cases, each product between 4 groups
Score value compares 0. 05-0. 01 of P <, and difference has significant.Subject's statistic analysis result is shown in Table 1.
1 200 Microcirculation of Nailfold of table are taken preceding by inspection result overall distribution
5. 2 microcirculations reason application product subject screening
Using weighted integral as reference in 200 subjects, it is divided into test group and control group, wherein test group random screening goes out
I grades and II grades subject 180, and timing 2 times/d, 30min/ times, is affixed on sea of blood cave and uterus using microcirculation reason application
Cave, total 90d.Subject needs quiet rest 15-30 min before being examined using this product, does not feed, non-smoking etc., mental relaxation,
Left hand is put naturally under the microscope, be coated at nail fold fold cedar oil observation microcirculation overall picture, selection marker blood vessel into
Row observation in detail, while carrying out result record.Just, using detection 1 time before microcirculation reason application, every 10d was 1 period in use
Detection 1 time, until use terminates.For the microcirculation dynamic change for being best understood from statistics patient, the testing time is fixed on same
Time, and scored with field Niu Shi weighted and integral method.Using microcirculation tester by with 7d be 1 period measuring subject
Microcirculation of Nailfold indices, and data sample library is established, show that microcirculation reason application improves Microcirculation of Nailfold by data analysis
State, to infer that microcirculation reason application can improve the blood circulation in affected part.In addition control 20 people's total mark value of group selection is greater than
1.5 as a control group, it is desirable that guarantees work and rest rule, cooking is emotionally stable, carries out appropriate physical training and forbid heat
It applies, other physical therapies such as acupuncture.By observation subject using microcirculation reason application product, promote the form of Microcirculation of Nailfold
Index, fluidised form index, loop Zhou Zhibiao with the presence or absence of changing to a certain degree, so that Microcirculation of Nailfold is detected as microcirculation reason application function
It imitates and dialectical provides the index of objective quantitative.
5. the tested front and back interpretation of result of 3 test groups
3. 5. the comparison of 1 integrated value tested front and back and significance are as can be seen from Table 2, total mark value take front and back from
2.392 ± 0.934 to 0.823 ± 0.438, comprehensive descision also therefrom in mild pain to normal range (NR), illustrates that affected part blood is micro-
It is fairly obvious that circulation improves situation.Find that in addition to microcirculation comprehensive descision is obviously improved except this affected part, subject is in body through investigation
Conditioning and respiratory system improve also more obviously, wherein improving 20 people of sleep, different degrees of pain improves 120 people, all tested
In person, dysmenorrhea improves 137 people, and skin improves 3 people.It is tested to paired samples by table 3 using SPASS from the point of view of analyzing result,
Statistically there is significant difference (P < 0. 01).
3. 5. 2 microcirculation cycle detection variation tendencies
As subject is using the extension of microcirculation reason application total time, Morphology score and total mark value are in be decreased obviously trend,
Fluidised form and loop Zhou Jifen variation are unobvious.As it can be seen that microcirculation reason application can improve vascular morphology very well, reduce lopsided blood vessel,
The measured value for outputting and inputting branch tube diameter improves, and reaches in range of normal value.
5. 4 two groups of Microcirculation of Nailfold improvement are compared
By analyze above it is found that before test group subject be mostly mild or moderate exception, be mainly shown as input and output branch tube diameter survey
Magnitude is small, and loop top diameter is small, and pipe loop is short, and flow component is in grain stream, and with the presence of some lopsided pipe loops.Microcirculation reason is used to apply
90d is mostly normal after patch, and it is preferable to show that Microcirculation of Nailfold improves situation.Test group applies front and back wherein shape using microcirculation reason
State integral improve it is the most obvious, integrated integral improvement also be it is significant, be statistically analyzed, with significant difference, P < 0. 01.
Control group personnel have different degrees of improvement under the premise of keeping certain diet, work and rest and physical training.Two groups of nail folds are micro-
Circulation improves comparative situation and is shown in Table 4 and table 5.
5.5 two groups of pain (VRS scoring), which improve, compares
It is shown by Microcirculation of Nailfold experimental result, subject's microcirculation periodically improves.Simultaneously by the following table 6 analyze it is found that by
For examination person using microcirculation reason application front and back, the change of pain scores classification is as follows.Subject is managed using microcirculation and is applied as the result is shown
After patch, the primary dysmenorrhea of light moderate is effectively improved.After statistical procedures, there is significant difference, P < 0. 01.
6 conclusions
The above test results show that test group case 180, being effectively improved 140, (20 sleep improvements, 120 are in various degree
Pain improve), total effective rate 77.77%；Control group effective percentage is 10%.Experimental group total mark value is before and after use from 2.392
± 0.934 to 0.823 ± 0.438, and there is significant difference (P < 0. 01) through statistical analysis.Using tested before reason application
There are apparent Microcirculation of Nailfold obstacle, items integrals to increase by person, and integrating after using microcirculation reason application reduces, equal table
Reveal the increase of pipe loop number, pipe loop length increases, and inputs branch thickening, and color reddens, and flow velocity is accelerated, and lopsided pipe loop number is reduced
Deng the Microcirculation of Nailfold of subject can be significantly improved.
The reason that the external application that inventor further tests embodiment 2, embodiment 3 is prepared improves microcirculation is applied to will
The improvement of hope person's Microcirculation of Nailfold.
2 test group case of embodiment 180 is effectively improved 120 (18 sleep improvements, 102 different degrees of pain
Improve), total effective rate 66.67%；Control group effective percentage is 12%, has significant difference (P < 0. 01) through statistical analysis.
3 test group case of embodiment 180 is effectively improved 112 (15 sleep improvements, 97 different degrees of pain
Improve), total effective rate 62.22%；Control group effective percentage is 10%, has significant difference (P < 0. 01) through statistical analysis.
Microcirculation of Nailfold is detected as microcirculation reason application, and effect is dialectical provides the index of objective quantitative, and has preferable improvement
Effect, further relating to microcirculation reason application of the invention has effects that improve blood circulation of human body to relieve pain.
Claims (7)
1. a kind of external application improves the composition of microcirculation, forming includes nano-scale far infrared ceramic powder, nanoscale Tourmaline powder,
Piperine, capsaicine, vanillyl alcohol butyl ether, oil of ginger, garlic oil, menthol, Japan pepper essential oil.
2. the composition that external application according to claim 1 improves microcirculation, which is characterized in that it includes that nanoscale is remote that it, which is formed,
20-30 parts of infrared ceramic powder, 10-20 parts of nanoscale Tourmaline powder, 5-10 parts of piperine, 10-15 parts of capsaicine, vanillyl alcohol butyl ether
5-10 parts, 10-20 parts of oil of ginger, 10-20 parts of garlic oil, 5-10 parts of menthol, 10-20 parts of Japan pepper essential oil, by weight.
3. the reason application that a kind of external application improves microcirculation comprising hypothallus, heating layer and surface covering, which is characterized in that institute
Heating layer is stated to be made of the external application improvement microcirculation composition of claims 1 or 2.
4. the reason application that external application according to claim 3 improves microcirculation, which is characterized in that the preparation packet of the hypothallus
Include following steps:
(1) silica gel is chosen, rubber, latex, hexadecanol, zinc stearate, polyvinyl chloride, addition colloidal sol pot heating is mixed and stirred for equal
It is even；
(2) raw material after mixing evenly is continued to be heated to 120-140 DEG C in colloidal sol pot；
(3) organic sulfurizing agent is added in the mixture in step (2) and high saturation naphthenic base plasticizer mixes, make silicon rubber point
Son crosslinks sulfurization and plasticization at high temperature；
(4) composition in step (3) is poured into mold.
5. the reason application that external application according to claim 4 improves microcirculation, which is characterized in that the weight of step (1) each component
Amount ratio are as follows: 25-40 parts of silica gel, 10-30 parts of rubber, 1-10 parts of latex, 0.8-1.5 parts of hexadecanol, 0.3-1 parts of zinc stearate,
25-55 parts of polyvinyl chloride.
6. the reason application that external application according to claim 3 improves microcirculation, which is characterized in that the preparation packet of the heating layer
Include following steps:
(1) composition for choosing external application improvement microcirculation of any of claims 1 or 2 is uniformly mixed；
(2) mixture of step (1) is sufficiently mixed with hypothallus at 110-130 DEG C；
(3) it suppresses and is cooled and shaped in a mold to the composition in step (2), form silicone rubber plate.
7. the reason application that external application according to claim 5 improves microcirculation, which is characterized in that the production of the surface covering
Method are as follows: by the hydrosol and hot melt adhesive even application on silicone rubber plate, attached with self-adhesive paper.
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| CN201810854697.7A CN109045251A (en) | 2018-07-30 | 2018-07-30 | A kind of external application improves composition and its application of microcirculation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110051934A (en) * | 2019-04-09 | 2019-07-26 | 马南行 | A kind of wave band containing far infrared improves the preparation method for managing application of microcirculation in human body |
| CN111359103A (en) * | 2020-03-18 | 2020-07-03 | 大连迪麦医疗科技有限公司 | Fragrant dressing plaster containing far infrared energy variable temperature, preparation method thereof and tabletting mold |
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| CN1315200A (en) * | 2000-03-31 | 2001-10-03 | 朱大岩 | Exterior-applied medicine for treating lumbar intervertebral disk protrusion |
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| CN110051934A (en) * | 2019-04-09 | 2019-07-26 | 马南行 | A kind of wave band containing far infrared improves the preparation method for managing application of microcirculation in human body |
| CN111359103A (en) * | 2020-03-18 | 2020-07-03 | 大连迪麦医疗科技有限公司 | Fragrant dressing plaster containing far infrared energy variable temperature, preparation method thereof and tabletting mold |
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Application publication date: 20181221 |