CN108498762A - A kind of Chinese medicine compound prescription for improving light moderate depressive patients with insomnia - Google Patents
A kind of Chinese medicine compound prescription for improving light moderate depressive patients with insomnia Download PDFInfo
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- CN108498762A CN108498762A CN201810716661.2A CN201810716661A CN108498762A CN 108498762 A CN108498762 A CN 108498762A CN 201810716661 A CN201810716661 A CN 201810716661A CN 108498762 A CN108498762 A CN 108498762A
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- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 1
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- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 description 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 description 1
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- QZZGJDVWLFXDLK-UHFFFAOYSA-N tetracosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(O)=O QZZGJDVWLFXDLK-UHFFFAOYSA-N 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
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Abstract
The invention discloses a kind of Chinese medicine compound prescriptions for improving light moderate depressive patients with insomnia, including:7 11 parts of radix bupleuri, 48 parts of peppermint, 8 12 parts of armeniaca mume, 10 14 parts of rose, 13 17 parts of Radix Curcumae, 18 22 parts of Flos Albiziae, 18 22 parts of Fructus Forsythiae, 28 32 parts of mother-of-pearl, 28 32 parts of silkworm excrement, 8 12 parts of chrysanthemum, 28 32 parts of Polygonum multiflower knotweed, 13 17 parts of RADIX POLYGALAE PREPARATA, 13 17 parts of wilsonii, 18 22 parts of grass-leaved sweetflag, 13 17 parts of cassia seed;It is parts by weight.Clinical application effect shows that Chinese medicine compound prescription of the present invention can be used for assisting alprazolam treatment of insomnia patients, significant effect.Therefore, Chinese medicine compound prescription of the present invention can be used for preparing the drug for improving light moderate depressive patients with insomnia, can such as make the pack of handy and safe.
Description
Technical field
The invention belongs to field of medicaments, are related to a kind of Chinese medicine compound prescription for improving light moderate depressive patients with insomnia.
Background technology
Melancholia is caused by emotional discomfort, depression and stagnation of QI, and to feel depressed, irritable emotion, chest are completely bored, side of body rib is swollen
Bitterly or irritability is easily cried, or if any a kind of disease that the diseases such as foreign matter infraction are main clinical manifestation in pharynx.Often with insomnia, table
Be now evening difficulty falling asleep, night dream mostly easily wakes up, is difficult to fall asleep again after morning early awakening, except some patientss due to body illness or
Outside drug-induced insomnia, also most of patient is since nervous, excessively concern sleep cause insomnia, patient is easy from night
Wake up be developing progressively for sit up whole night in addition it is for years sit up, seriously affect life.
Depression exists《Interior warp》There is the strongly fragrant discussion of five gas,《Synopsis Golden Chamber》Describe the hysteria and globus hysteriocus for belonging to melancholia
Two kinds of diseases,《Danxi's experiential therapy》Propose that gas, blood, fire, food, wet, phlegm six is strongly fragrant says, the Ming Dynasty《Medicine main story》Melancholia is used first
This nomenclature of diseases.Traditional Chinese medicine thinks that melancholia is since depression and stagnation of QI causes liver dysfunction, the dysfunction of the spleen in transport, the heart to be become homeless foster, internal organs
Yin and yang qi and blood disorder discusses the principle controlled using differentiation of symptoms and signs for classification of syndrome according to the different type of melancholia, and traditional Chinese medicine in treating insomnia also has needle in addition
Pierce therapy, acupoint application therapy etc..Western medical treatment depression and insomnia mainly use Western medicine, the former generally comprises selective 5- hydroxyls color
(SSRI represents agents fluoxetine, Paxil, Sertraline, Fluvoxamine, Citalopram and Ai Sixi to amine reuptaking inhibitor
Phthalein Pulan), serotonin and norepinephrine reuptake inhibitors (SNRI represents drug Venlafaxine and Duloxetine),
Norepinephrine and specific serotonin energy antidepressants (NaSSA represents drug Mirtazapine), tricyclic antidepressants, Fourth Ring class resist
Depressant drug and monoamine oxidase inhibitors;The latter generally comprises Benzodiazepines, phenobarbital class, antianxiety class and other are novel
Drug.It can also adopt psychotherapy with insomniac to the light moderate depressive patients of primary.Chinese medicine, doctor trained in Western medicine and psychotherapy can
Alleviate light modest depression to a certain extent in the symptom with insomniac, these therapies need patient periodically to go to hospital, or open
Have prescription, or seek the therapist of profession, antipsychotics Time of Administration is unsuitable long in addition, therefore there are drawbacks.
Aromatotherapy is with the special nature with aromatic odor drug, to improve human circulation and endocrine side
Method, handy and safe.Material molecule particle with aromatic odor is minimum, can be by way of room temperature or high-temperature heating, from people
Skin, respiratory tract of body etc. are rapidly introduced into the blood circulation of human body, so as to improve the skin of human body, blood circulation, endocrine
Deng allowing human body to generate different feelings.The study found that a variety of aromatics Chinese medicines have calmness, Xie Yu, tranquilizing the mind, function for assisting sleep.
Invention content
Present invention aims at a kind of Chinese medicine compound prescription for improving light moderate depressive patients with insomnia is provided, medicine can be made
Packet is placed in bedside sleeping.
The above-mentioned purpose of the present invention is achieved by following technical solution:
A kind of Chinese medicine compound prescription for improving light moderate depressive patients with insomnia, including:7-11 parts of radix bupleuri, 4-8 parts of peppermint are green
8-12 parts of calyx plum, 10-14 parts of rose, 13-17 parts of Radix Curcumae, 18-22 parts of Flos Albiziae, 18-22 parts of Fructus Forsythiae, 28-32 parts of mother-of-pearl,
28-32 parts of silkworm excrement, 8-12 parts of chrysanthemum, 28-32 parts of Polygonum multiflower knotweed, 13-17 parts of RADIX POLYGALAE PREPARATA, 13-17 parts of wilsonii, grass-leaved sweetflag 18-22
Part, 13-17 parts of cassia seed;It is parts by weight.
Preferably, the Chinese medicine compound prescription includes:9 parts of radix bupleuri, 6 parts of peppermint, 10 parts of armeniaca mume, 12 parts of rose, Radix Curcumae 15
Part, 20 parts of Flos Albiziae, 20 parts of Fructus Forsythiae, 30 parts of mother-of-pearl, 30 parts of silkworm excrement, 10 parts of chrysanthemum, 30 parts of Polygonum multiflower knotweed, 15 parts of RADIX POLYGALAE PREPARATA, thorn
15 parts of slender acanthopanax, 20 parts of grass-leaved sweetflag, 15 parts of cassia seed;It is parts by weight.
A kind of resolving stagnation for tranquilization pack, above-mentioned Chinese medicine compound prescription is placed in ventilative container.
Application of the above-mentioned Chinese medicine compound prescription in preparing the drug for improving light moderate depressive patients companion insomnia.
Each raw material is essential in Chinese medicine compound prescription of the present invention, and lacking any of which, medicine is all to lead to drop significant in efficacy simply
It is low, wherein:Radix bupleuri, it is pungent, bitter, it is slightly cold, Return liver, courage, lung channel;Soothing liver-qi stagnation, yang invigorating;For distending pain in the chest and hypochondrium;Containing volatile oil,
Bupleurumol, oleic acid, leukotrienes, palmitic acid, stearic acid, carnaubic acid, glucose, saponin (Markets Drug, saikoside member F,
E, G, longispinogenin) etc..Peppermint:Peppermint, pungent, cool, return lung, Liver Channel;Dispelling wind and heat from the body, head clearing, soothing the liver promoting the circulation of qi;Containing peppermint
Alcohol, menthones, menthyl acetate, amphene, limonene, isomenthone, firpene, piperitenone, resin, tannin, Rosmarinic acid.It is green
Calyx plum:Armeniaca mume, it is slightly sour, puckery, it puts down, Return liver, stomach, lung channel;Suppressing the hyperactive liver and easing the stomach, harmonizing the functional activities of vital QI;For distending pain in the chest and hypochondrium, neurasthenia;
Containing benzaldehyde, isoeugenol, the volatile oil such as benzoic acid.Rose:Rose, sweet, slight bitter, temperature, Return liver, the spleen channel;Qi-regulating solution
It is strongly fragrant;Containing volatile oil (citronellol, Geraniol, nerol, Eugenol, benzyl carbinol), nonyl alcohol, benzyl alcohol, linalool, acetic acid benzene
Ethyl ester, quercitrin, tannin etc..Radix Curcumae:Radix Curcumae, it is pungent, bitter, it trembles with fear, Return liver, the heart, lung channel;Regulating qi to disperse stagnation, heart fire-clearing upset-relieving;For pyreticosis
Coma, epilepsy are gone mad;Containing volatile oil (amphene, camphor, sesquiterpene, master are curcumene, sesquiterpene alcohols etc.), curcumin takes off
Methoxyl group curcumin, bisdemethoxycurcumin, turmerone, aryl turmerone, phellandrene etc..Flos Albiziae:Flos Albiziae, sweet and neutral,
Converge to heart and liver channels;Resolving stagnation for tranquilization;Containing saponin(e, flavone compound, tannin, a variety of lignanoids, glucosides, pyridinol derivative
Glucosides etc..Fructus Forsythiae:Fructus Forsythiae, it is bitter, pungent, it is slightly cold, return lung, the heart, small intestinl channel;It is clearing heat and detoxicating;Containing forsythol, sterol compound, saponin
(no hemolytic), Flavonoids, horse tongue resinol glucoside, oleanolic acid etc..Mother-of-pearl:Mother-of-pearl, it is salty, it trembles with fear, Return liver, the heart channel of Hang-Shaoyin;
Calm the nerves and calms the frightened, calming the liver, heat-clearing improving eyesight;Calcium carbonate, magnesium, iron, silicate, sulfate, phosphate and chloride etc..Silkworm
Sand:Silkworm excrement, sweet, acrid, warm, Return liver, spleen, stomach;Pungent and sweet flavors can be used for dispersing, stomach dampness elimination;Contain chlorophyll, pohytol, cupreol, courage
Sterol, ergosterol, Lupeol etc..Chrysanthemum:Chrysanthemum, it is pungent, sweet, bitter, it is slightly cold, return lung, Liver Channel;Dispelling wind and heat from the body, suppressing liver-YANG,
It clears liver and improve vision, there is sedation;Contain volatile oil (borneol, camphor, chrysanthenone etc.), chrysanthemum glycosides, flavones, stachydrine, robinin
Deng.Polygonum multiflower knotweed:The vine of multiflower knotweed, sweet and neutral, converge to heart and liver channels;Nourishing blood and tranquilization has sedative-hypnotic effect, extends sleeping time;Containing anthraquinone
Class compound (rheum emodin, Chrysophanol, Physcion), cupreol.Radix Polygalae:Radix Polygalae, bitter, acrid in flavour and warm in nature, the thoughts of returning home, kidney, lung channel;
Tranquilize the mind and promote the intelligence, Xie Yu;Containing saponin (presenegenin A, B, Roots of Polygala tenuifolia element), polygalytol, N-acetylglucosamine, alkaloid
Tenuidine, fat oil, resin etc..Wilsonii:Wilsonii, pungent, slight bitter, temperature, returns spleen, kidney, the heart channel of Hang-Shaoyin;Benefiting qi for tranquillization;Contain
Daucosterol, Syringin, Eleutheroside B 1, C, D, E, sinapyladehyde glycoside, coniferyl aldehyde glycoside, coniferin, Liriodendron
Glucoside, amygdalin etc..Grass-leaved sweetflag:Grass-leaved sweetflag, pungent, bitter, temperature, the thoughts of returning home, stomach;Have one's ideas straightened out slit phlegm, inducing resuscitation intelligence development;It is thin containing volatile oil beta-
Octyl ether, asarone, carypohyllene, α-Humuleno, γ-asarone, δ-δ-cadinene, myristic acid, Thymol, sekishone, ammonia
Base acid, organic acid, carbohydrate etc..Cassia seed:Cassia seed, it is sweet, bitter, salty, it is slightly cold, Return liver, large intestine channel;Removing heat from the liver improving eyesight, except wind dissipates
Heat;Contain the anthraquinones such as Rhein, rheum emodin, aloe-emodin, cassia seed element, aurantio-obtusin, obtusin, Cassia
The naphthazoles letones such as glycosides, Cassia ketone, toralactone, sterol, aliphatic acid etc..
Compound of the present invention can be used for assisting Western medicine to improve light moderate depressive patients with insomnia, significant effect.
Specific implementation mode
Essentiality content of the present invention is specifically introduced with reference to embodiment, but does not limit the protection model of the present invention with this
It encloses.
One, clinical data
1, general information
It collects medical to 06 month 2018 in January, 2018 in have a sleepless night depressed special outpatient clinic of Zhejiang Provincial Tongde Hospital
The light moderate depressive patients of 213 primary are randomly divided into seminar 109 with insomniac, control group 104, two groups of patients'
Gender, age equal no difference of science of statistics (equal P > 0.05).
2, it is included in and exclusion criteria
Inclusion criteria:(1) patient HAMD scores>20 points, with difficulty falling asleep, sleeping time is few, poor sleeping quality, long-term nothing
The symptoms such as method sleep;(2) informed consent form is signed.Exclusion criteria:(1) depression caused by other organic diseases and mistake
It sleeps;(2) it is the gestational period or women breast-feeding their children and Alcoholic Dependent Patients.
Two, therapy
Sertraline is given by seminar, and 100mg, daily once the treatment of joint alprazolam, 0.4mg take one every night
It is secondary;Coordinate resolving stagnation for tranquilization pack to treat simultaneously, radix bupleuri 9g, peppermint 6g, armeniaca mume 10g, rose 12g, Radix Curcumae are contained in pack
15g, Flos Albiziae 20g, Fructus Forsythiae 20g, mother-of-pearl 30g, silkworm excrement 30g, chrysanthemum 10g, Polygonum multiflower knotweed 30g, RADIX POLYGALAE PREPARATA 15g, wilsonii
The pack is placed in pillow side by 15g, grass-leaved sweetflag 20g, cassia seed 15g;
Control group is given only Sertraline 100mg, and daily once joint alprazolam treats 0.4mg, takes one every night
It is secondary;
Curative effect is observed after treating 4 weeks.
Observation index and evaluation method:(1) Hamilton depressive scale:Hamilton Depression Scale (Hamilton
Depression Scale, HAMD) it is worked out in nineteen sixty by Hamilton, it is to apply the most when clinically evaluating depressive state
Universal scale, assessment method is easy, and reliability and validity are higher, can evaluate the severity and therapeutic effect of the state of an illness.By
Trained 2 assessment officers carry out joint inspection:The Cut-off score of JM;<8 points, for no depressive symptom;>20 points, for it is light or in
Isocratic depression;Total score>35 points, be major depression.(2) Pittsburgh Sleep Quality Index (PSQI) is that Buysse DJ are equal to
1989 establishment Sleep Quality Index scale, reliability and validity are higher, with Polysomnography test result have compared with
High correlation, it has also become the common scale of research both at home and abroad and psychiatric department evaluation.Before being treated to each patient by medical practitioner
It gives a mark with the sleeping time after treatment, time for falling asleep:Sleeping time>0 point is counted within 7 hours, counts 1 point within 6~7 hours, 5~6 is small
When count 2 points,<Count 3 points within 5 hours;Time for falling asleep≤15 point count 0 point, and 16~30 points are counted 1 point, and 31~60 2 points of meters, >=60 points are counted 3
Point.
Statistical method:Statistical disposition is carried out to data using 22.0 softwares of SPSS, all data are inputted into computer,
Establish database, detection data classified variable χ2It examines, is examined using t between numerical variable, P<0.05 has statistics for difference
Meaning.
Three, result
1-2 is the results are shown in Table, compared with the control group, each index of seminar significantly improves, the statistically significant (P of difference<
0.05)。
The pretherapy and post-treatment PSQI Measuring scale assessings result of 1 each group patient of table
Note:a:Compared with before same group for the treatment of, P<0.05;b:Compared with after control group treatment, P<0.05.
The pretherapy and post-treatment HAMD Measuring scale assessings result of 2 each group patient of table
Note:a:Compared with before same group for the treatment of, P<0.05;b:Compared with after control group treatment, P<0.05.
Further study show that compound composition of the present invention can slightly be adjusted in following range, i.e.,:7-11 parts of radix bupleuri is thin
4-8 parts of lotus, 8-12 parts of armeniaca mume, 10-14 parts of rose, 13-17 parts of Radix Curcumae, 18-22 parts of Flos Albiziae, 18-22 parts of Fructus Forsythiae, pearl
It is 28-32 parts female, 28-32 parts of silkworm excrement, 8-12 parts of chrysanthemum, 28-32 parts of Polygonum multiflower knotweed, 13-17 parts of RADIX POLYGALAE PREPARATA, 13-17 parts of wilsonii, stone
18-22 parts of calamus, 13-17 parts of cassia seed, is parts by weight.Using effect and the using effect of above-mentioned composition are almost the same,
PSQI Measuring scale assessings result, HAMD Measuring scale assessing results are almost the same, no significant difference (P > 0.05).
Above-mentioned clinical effectiveness shows that compound of the present invention can be used for assisting Sertraline joint alprazolam to treat light moderate suppression
Strongly fragrant disease is with insomnia, significant effect.Therefore, Chinese medicine compound prescription of the present invention can be used for preparing the medicine for improving light moderate depressive patients with insomnia
Object can make the pack of handy and safe.
The effect of above-described embodiment is specifically to introduce the essentiality content of the present invention, but those skilled in the art should know
Protection scope of the present invention should not be confined to the specific embodiment by road.
Claims (4)
1. a kind of Chinese medicine compound prescription for improving light moderate depressive patients with insomnia, which is characterized in that including:7-11 parts of radix bupleuri is thin
4-8 parts of lotus, 8-12 parts of armeniaca mume, 10-14 parts of rose, 13-17 parts of Radix Curcumae, 18-22 parts of Flos Albiziae, 18-22 parts of Fructus Forsythiae, pearl
It is 28-32 parts female, 28-32 parts of silkworm excrement, 8-12 parts of chrysanthemum, 28-32 parts of Polygonum multiflower knotweed, 13-17 parts of RADIX POLYGALAE PREPARATA, 13-17 parts of wilsonii, stone
18-22 parts of calamus, 13-17 parts of cassia seed;It is parts by weight.
2. the Chinese medicine compound prescription according to claim 1 for improving light moderate depressive patients with insomnia, which is characterized in that packet
It includes:9 parts of radix bupleuri, 6 parts of peppermint, 10 parts of armeniaca mume, 12 parts of rose, 15 parts of Radix Curcumae, 20 parts of Flos Albiziae, 20 parts of Fructus Forsythiae, mother-of-pearl
30 parts, 30 parts of silkworm excrement, 10 parts of chrysanthemum, 30 parts of Polygonum multiflower knotweed, 15 parts of RADIX POLYGALAE PREPARATA, 15 parts of wilsonii, 20 parts of grass-leaved sweetflag, cassia seed 15
Part;It is parts by weight.
3. a kind of resolving stagnation for tranquilization pack, it is characterised in that:Chinese medicine compound prescription described in claims 1 or 2 is placed in gas-permeable container to be made.
4. application of the Chinese medicine compound prescription as claimed in claim 1 or 2 in preparing the drug for improving light moderate depressive patients companion insomnia.
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Citations (3)
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CN105615443A (en) * | 2015-12-31 | 2016-06-01 | 孔繁紫 | Medicine pillow improving sleep |
CN106421467A (en) * | 2016-10-31 | 2017-02-22 | 杨永久 | Pharmaceutical composition for treating insomnia and depression |
CN108096445A (en) * | 2018-03-01 | 2018-06-01 | 广西中医药大学第附属医院 | A kind of Chinese medicine package for treating insomnia and preparation method thereof |
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2018
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CN105615443A (en) * | 2015-12-31 | 2016-06-01 | 孔繁紫 | Medicine pillow improving sleep |
CN106421467A (en) * | 2016-10-31 | 2017-02-22 | 杨永久 | Pharmaceutical composition for treating insomnia and depression |
CN108096445A (en) * | 2018-03-01 | 2018-06-01 | 广西中医药大学第附属医院 | A kind of Chinese medicine package for treating insomnia and preparation method thereof |
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