CN109045159A - It is a kind of to improve near-sighted blueberry lutein ester composition and application - Google Patents
It is a kind of to improve near-sighted blueberry lutein ester composition and application Download PDFInfo
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- CN109045159A CN109045159A CN201811234169.8A CN201811234169A CN109045159A CN 109045159 A CN109045159 A CN 109045159A CN 201811234169 A CN201811234169 A CN 201811234169A CN 109045159 A CN109045159 A CN 109045159A
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- myopia
- lutein ester
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- 208000001491 myopia Diseases 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 title claims abstract description 40
- 235000003095 Vaccinium corymbosum Nutrition 0.000 title claims abstract description 39
- 235000017537 Vaccinium myrtillus Nutrition 0.000 title claims abstract description 39
- 235000021014 blueberries Nutrition 0.000 title claims abstract description 39
- 240000000851 Vaccinium corymbosum Species 0.000 title claims abstract description 38
- 230000004379 myopia Effects 0.000 claims abstract description 59
- 239000000843 powder Substances 0.000 claims abstract description 36
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 210000002969 egg yolk Anatomy 0.000 claims abstract description 15
- 230000007062 hydrolysis Effects 0.000 claims abstract description 12
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 12
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims abstract description 11
- 235000013734 beta-carotene Nutrition 0.000 claims abstract description 11
- 239000011648 beta-carotene Substances 0.000 claims abstract description 11
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims abstract description 11
- 229960002747 betacarotene Drugs 0.000 claims abstract description 11
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims abstract description 11
- 229940087603 grape seed extract Drugs 0.000 claims abstract description 10
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 10
- 235000012054 meals Nutrition 0.000 claims abstract description 10
- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract description 10
- 239000006187 pill Substances 0.000 claims description 10
- 230000036541 health Effects 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 235000013402 health food Nutrition 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 239000006188 syrup Substances 0.000 claims description 5
- 235000020357 syrup Nutrition 0.000 claims description 5
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 2
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 244000283207 Indigofera tinctoria Species 0.000 claims 1
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 235000021028 berry Nutrition 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 11
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 238000009776 industrial production Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 7
- 238000007796 conventional method Methods 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000004438 eyesight Effects 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000002775 capsule Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 238000001694 spray drying Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000005180 public health Effects 0.000 description 3
- 208000006550 Mydriasis Diseases 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 229940038487 grape extract Drugs 0.000 description 2
- 230000004402 high myopia Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000001747 pupil Anatomy 0.000 description 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- 235000005881 Calendula officinalis Nutrition 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 240000000785 Tagetes erecta Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000077233 Vaccinium uliginosum Species 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 125000001409 beta-carotene group Chemical group 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- -1 is sized mixing Substances 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L15/00—Egg products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/20—Malt products
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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- A61K35/56—Materials from animals other than mammals
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Abstract
It is to be grouped as by weight by following groups the invention discloses a kind of blueberry lutein ester composition for improving myopia and application, its composition: 15~30 parts of grape seed extract, 15~30 parts of blueberry powder, 10~20 parts of Fructus lycii P.E, 1~10 part of lutein ester, hydrolysis 1~10 part of yolk powder, 5~15 parts of wheat-germ meal, 5~15 parts of apple powder, 1~10 part of beta carotene.It is proved by human experimentation, each raw material has synergistic effect in composition of the invention, can effectively improve myopia.Preparation method of composition of the invention is simple, stable process conditions, is suitble to scale industrial production.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and applications, more particularly to a kind of blueberry lutein ester group for improving myopia
Close object and application.
Background technique
Myopia is listed in one of big disease in the world three, national myopia number unexpectedly nearly 400,000,000, and wherein teenager is about
2.7 hundred million.Myopia key lab of Ministry of Public Health director, Fudan University's ophthalmology professor Chu Renyuan tell " life Times " reporter, closely
Nian Lai, Chinese myopia rate have the tendency that sharply increasing.China human mortality Shortsightedness prevalence is 33%, is world average level 22%
1.5 times, disease incidence is only second to Japan, accounts for second place of the world, and newly-increased myopia is about 6% every year.
Wherein, myopia of student disease incidence in China's occupies the second in the world, and number occupies first of the world, near-sighted disease incidence be up to 50% to
60%.Investigation display, China pupil poor sight recall rate is 28%, junior school student 60%, high school student 85%, Er Qieyou
The trend constantly risen.In 8~12 years old pupil in China, there are about 47 children just a myopia, and near-sighted disease incidence is about
It is 23%, middle school student are about 55%, and university student is about 76%.
Myopia is needed from diet, movement, living habit various aspects are comprehensive is nursed.Juvenile shortsightedness
Crack cause it is considerably complicated, overview is got up not outer congenital heredity reason and acquired environment factor.The former accounts for 20%, Hou Zhezhan
80%, if it is high myopia that parent both sides, which have a side, children's heritability is 56%, if both sides are high myopia, heritability is
100%.And environmental factor is can well to be reinforced with eye habit by improving eye-using environment and paying attention to forming to the pre- of myopia
It is anti-.Avoiding the main means of myopia has: reducing child's burden, forms well with eye habit, increases outdoor sport and pay attention to eyes
The five major class modes such as health care, the food for taking sight protectio.Many pre- myopia preventions, the product of improvement myopia currently on the market is big
Majority is all medical instrument, is used for a long time first is that inconvenient, cannot be from solving the problems, such as at all second is that only play relaxation effect.
Oral prevention and the product for improving myopia are also multifarious, and majority is all the extra-nutrition agent of vitamins, because of the invention one kind
Pure plant product, effectively can prevent and improve myopia becomes a major issue for needing to solve at this stage.
Summary of the invention
The first purpose of this invention is to overcome the deficiencies of the prior art and provide a kind of blueberry lutein for improving myopia
Ester composition.
A second object of the present invention is to provide a kind of blueberry lutein ester compositions for improving myopia to improve closely in preparation
Depending on the application in health care product or health food.
Third object of the present invention is to provide the oral systems comprising a kind of blueberry lutein ester composition for improving myopia
Agent.
Fourth object of the present invention is to provide the oral system comprising a kind of blueberry lutein ester composition for improving myopia
Agent improves the application in shortsightedness health care product or health food in preparation.
Technical solution of the present invention is summarized as follows:
A kind of blueberry lutein ester composition improving myopia, is grouped as by following groups: grape seed extract 15 by weight
~30 parts, 15~30 parts of blueberry powder, 10~20 parts of Fructus lycii P.E, 1~10 part of lutein ester, hydrolysis 1~10 part of yolk powder,
5~15 parts of wheat-germ meal, 5~15 parts of apple powder, 1~10 part of beta carotene.
Preferably, 18 parts of grape seed extract, 25 parts of blueberry powder, 18 parts of Fructus lycii P.E, 3 parts of lutein ester, hydrolysis
5 parts of yolk powder, 10 parts of wheat-germ meal, 10 parts of apple powder, 5 parts of beta carotene.
Above-mentioned composition improves the application in shortsightedness health care product or health food in preparation.
Oral preparation comprising above-mentioned composition.
The dosage form of above-mentioned oral preparation is preferably tablet, pulvis, granule, capsule, water-bindered pill agent, pill or syrup
Agent.
Above-mentioned oral preparation improves the application in shortsightedness health care product or health food in preparation.
Advantages of the present invention:
It was proved that having synergistic effect in composition of the invention between raw material, it can effectively improve myopia.This
The preparation method of composition of invention is simple, stable process conditions, is suitble to scale industrial production.
Specific embodiment
The disclosure in the source of each raw material below, be in order to enable those skilled in the art to more fully understand the present invention,
But the present invention is not imposed any restrictions.
Extract source:
(1) grape seed extract made of separating grape seed extract: is extracted through water using grape pip as raw material；Execution standard
For SW/T 1-2015；
(2) it blueberry powder: using blueberry as raw material, is process through techniques such as water extraction, concentration, spray drying；Product specification
For 10:1.Execution standard is GB/T 29602；
(3) it Fructus lycii P.E: using fructus lycii as raw material, is process through techniques such as drying, crushing, sieving, packagings；It holds
Rower is quasi- are as follows: " Chinese Pharmacopoeia " 2015 version one；
(4) it lutein ester: using marigold flower as raw material, is crushed by dehydration, ethyl alcohol extracts, low-molecular-weight alcohol purifies and true
Sky concentration and etc. produce.Lutein ester is the Ministry of Public Health's " public affairs about 7 kinds of new resource foods such as approval lactobacillus acidophilus
Accuse " new resource food of (2008 No. 12) approval.
(5) yolk powder is hydrolyzed: using egg yolk as raw material, through Protease Treatment, heating, centrifuge separation, spray drying etc.
Step produces.Hydrolysis yolk powder is Ministry of Public Health's " bulletin about approval hydrolysis yolk powder as new resource food " (2008
Year No. 20) new resource food of approval.
(6) it wheat-germ meal: using wheat gluten flour as raw material, is sized mixing, protease hydrolyzed, separation, filtering, spray drying etc.
Technique is made.Execution standard is LS/T 3210；
(7) it apple powder: using apple as raw material, is process through techniques such as water extraction, concentration, spray drying；Product specification
For 10:1.Execution standard is GB/T 29602；
(8) beta carotene: using retinyl acetate as starting material, with food additives β-made from chemical synthesis
Carrotene.Execution standard is GB 8821.
The present invention is further illustrated combined with specific embodiments below.
Embodiment 1
A kind of blueberry lutein ester composition improving myopia, is grouped as: grape seed extract 18g, blueberry by following groups
Powder 25g, Fructus lycii P.E 18g, lutein ester 3g, hydrolysis yolk powder 5g, wheat-germ meal 10g, apple powder 10g, beta carotene
5g。
Embodiment 2
A kind of blueberry lutein ester composition improving myopia, is grouped as: grape seed extract 15g, blueberry by following groups
Powder 30g, Fructus lycii P.E 10g, lutein ester 10g, hydrolysis yolk powder 1g, wheat-germ meal 15g, apple powder 5g, beta carotene
10g。
Embodiment 3
A kind of blueberry lutein ester composition improving myopia, is grouped as: grape seed extract 30g, blueberry by following groups
Powder 15g, Fructus lycii P.E 20g, lutein ester 1g, hydrolysis yolk powder 10g, wheat-germ meal 5g, apple powder 15g, beta carotene
1g。
Embodiment 4
A kind of blueberry lutein ester composition preparation improving myopia:
Each raw material is crushed, 80 meshes is crossed, weighs raw material by the component of each embodiment respectively, is uniformly mixed.
Embodiment 5
A kind of tablet of the blueberry lutein ester composition of improvement myopia comprising embodiment 1 is the group that will improve myopia
It closes object and adds pharmaceutically acceptable auxiliary material, particle is made according to a conventional method, tablet is made in tabletting.
The composition of embodiment 2 or a kind of improvement myopia of embodiment 3 is substituted to the composition of the present embodiment, it is other with this
Corresponding tablet is made in embodiment.
Embodiment 6
A kind of capsule of the blueberry lutein ester composition of improvement myopia comprising embodiment 1, will improve myopia
Composition adds pharmaceutically acceptable auxiliary material, and particle is made according to a conventional method, particle is packed into capsule.
The blueberry lutein ester composition of embodiment 2 or a kind of improvement myopia of embodiment 3 is substituted to the group of the present embodiment
Object is closed, corresponding capsule is made in other same the present embodiment.
Embodiment 7
A kind of granule of the blueberry lutein ester composition of improvement myopia comprising embodiment 1, will improve myopia
Composition adds pharmaceutically acceptable auxiliary material, and granule is made according to a conventional method, which can be used as solid beverage, convenient
It uses.
The blueberry lutein ester composition of embodiment 2 or a kind of improvement myopia of embodiment 3 is substituted to the group of the present embodiment
Object is closed, corresponding granule is made in other same the present embodiment.
Embodiment 8
A kind of pill of the blueberry lutein ester composition of improvement myopia comprising embodiment 1 is the group that will improve myopia
It closes object and adds pharmaceutically acceptable auxiliary material, water-bindered pill agent is made according to a conventional method.
The blueberry lutein ester composition of embodiment 2 or a kind of improvement myopia of embodiment 3 is substituted to the group of the present embodiment
Object is closed, corresponding water-bindered pill agent is made in other same the present embodiment.
Embodiment 9
A kind of pill of the blueberry lutein ester composition of improvement myopia comprising embodiment 1, will improve myopia
Composition adds pharmaceutically acceptable auxiliary material, and pill is made in drop according to a conventional method.
The blueberry lutein ester composition of embodiment 2 or a kind of improvement myopia of embodiment 3 is substituted to the group of the present embodiment
Object is closed, corresponding pill is made in other same the present embodiment.
Embodiment 10
A kind of syrup of the blueberry lutein ester composition of improvement myopia comprising embodiment 1, will improve myopia
Composition adds pharmaceutically acceptable auxiliary material, and syrup is made according to a conventional method.
The blueberry lutein ester composition of embodiment 2 or a kind of improvement myopia of embodiment 3 is substituted to the group of the present embodiment
Object is closed, corresponding syrup is made in other same the present embodiment.
Embodiment 11
Take effect observation:
It is taken with composition of the invention to myopia student, successive administration 30 days, observes composition of the invention to close
Influence optionally.
1, experiment purpose
Observe a kind of influence for improving near-sighted blueberry lutein ester composition to myopia.
2, experimental material
2.1. test specimen
2.2.1 test medicine
A kind of title: blueberry lutein ester composition (embodiment 1, embodiment 2 and embodiment 3) improving myopia
Usage and dosage: once a day, each taking 4g
2.1.2 positive drug
2.1.2.1
Title: grape seed extract
Usage and dosage: once a day, each taking 1.2g
2.1.2.2
Title: Fructus lycii P.E
Usage and dosage: once a day, each taking 1.2g
2.1.2.3
Title: blueberry powder
Usage and dosage: once a day, each taking 4g
2.1.2.4
Title: beta carotene
Usage and dosage: once a day, each taking 0.4g
2.1.2.5
Title: lutein ester
Usage and dosage: once a day, each taking 0.4g
2.1.2.6
Title: hydrolysis yolk powder
Usage and dosage: once a day, each taking 1g
2.2 clinical trial data
2.2.1 diagnostic criteria:
Western medicine diagnostic criteria: it is formulated according to " the modern ophthalmology handbook " that People's Health Publisher publishes for 1993:
A. near vision is normal, and distant vision is poor；
B. Mydriasis Test & Optometry inspection is myope.
Tcm diagnosis standard: according to China Traditional Chinese Medicine Publishing House's publication higher medical institution teaching material " TCM Ophthalmology " in 2002
It formulates；
A. understand depending on nearly object, it is fuzzy depending on remote object；
B. Mydriasis Test & Optometry inspection is myope.
2.2.2 being included in case standard
1. meeting above-mentioned near-sighted diagnostic criteria；
2. overall health of patients is good, can adhere to daily；
3. age >=8 year old ,≤16 years old person.
2.2.3 general information meets the patient of above-mentioned diagnostic criteria, and being randomly divided into according to medical sequence is 9 groups, every group 10
Example, average age 13 years old, course of disease half a year was to 3 years.Ordinary circumstance is shown in Table 1.
Table 1
2.2.4 criterion of therapeutical effect is using common logarithm visual chart as standard.
Restore: naked eyesight is increased to >=1.0 after 1 course for the treatment of；
Effective: naked eyesight improves the above person of three rows after 1 course for the treatment of；
Effective: naked eyesight improves the above person of two rows after 1 course for the treatment of；
Invalid: naked eyesight is unchanged after 1 course for the treatment of or upper next line person.
Above method observes therapeutic effect after 1 course for the treatment of with 30 days for a course for the treatment of.
3. treatment results:
1,2,3 group of embodiment (is shown in Table 2) compared with positive drug control group.
Table 2 takes effect statistical form
| Grouping | Take number | Restore | Recovery from illness | Effectively | In vain | Total effective rate % |
| Example 1 group | 10 | 1 | 4 | 4 | 1 | 90 |
| 2 groups of embodiment | 10 | 1 | 3 | 4 | 2 | 80 |
| 3 groups of embodiment | 10 | 1 | 3 | 4 | 2 | 80 |
| Grape extract group | 10 | 0 | 4 | 1 | 5 | 50 |
| Fructus lycii P.E group | 10 | 0 | 1 | 3 | 6 | 40 |
| Blueberry powder group | 10 | 0 | 3 | 3 | 4 | 60 |
| Lutein ester group | 10 | 0 | 3 | 3 | 4 | 60 |
| Beta carotene group | 10 | 0 | 1 | 4 | 5 | 50 |
| Hydrolyze yolk powder group | 10 | 0 | 1 | 5 | 4 | 60 |
4, conclusion:
The experimental results showed that the embodiment of the present invention 1, embodiment 2, embodiment 3 and positive contrast's drug grape extract
Object, Fructus lycii P.E, blueberry powder, lutein ester, beta carotene, (data shows hydrolysis yolk powder: apple powder, wheat-germ meal
Do not improve myopia effect) improvement that can be different degrees of myopia, composition of the invention respectively with positive contrast's drug ratio
There is significant difference, illustrates embodiment 1, embodiment 2, embodiment 3 better than positive controls.
It is proved through above-mentioned test, the above medicinal material compounding is synergistic, has the near-sighted effect of good improvement.
Claims (6)
1. a kind of blueberry lutein ester composition for improving myopia, it is characterized in that being grouped as by weight by following groups: grape pip is mentioned
Take 15~30 parts of object, 15~30 parts of blueberry powder, 10~20 parts of Fructus lycii P.E, 1~10 part of lutein ester, hydrolysis yolk powder 1
~10 parts, 5~15 parts of wheat-germ meal, 5~15 parts of apple powder, 1~10 part of beta carotene.
2. a kind of composition for improving myopia according to claim 1, it is characterized in that 18 parts of the grape seed extract, indigo plant
25 parts of certain kind of berries powder, 18 parts of Fructus lycii P.E, 3 parts of lutein ester, hydrolysis 5 parts of yolk powder, 10 parts of wheat-germ meal, 10 parts of apple powder,
5 parts of beta carotene.
3. the composition of claims 1 or 2 improves the application in shortsightedness health care product or health food in preparation.
4. the oral preparation of the composition comprising claims 1 or 2.
5. oral preparation according to claim 4, it is characterized in that the dosage form of the preparation is tablet, pulvis, granule, glue
Wafer, water-bindered pill agent, pill or syrup.
6. the oral preparation of claim 4 or 5 improves the application in shortsightedness health care product or health food in preparation.
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| CN110169484A (en) * | 2019-04-23 | 2019-08-27 | 广东润源中天生物科技有限公司 | A kind of blueberry lutein ester pressed candy and preparation method thereof |
| CN113796534A (en) * | 2021-09-15 | 2021-12-17 | 沃德绿世界(溧水)生物科技有限公司 | Blueberry lutein ester tablet, production process and equipment thereof |
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| CN106889617A (en) * | 2016-08-29 | 2017-06-27 | 上海根植企业管理咨询有限公司 | A kind of eye health-care edible, its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110169484A (en) * | 2019-04-23 | 2019-08-27 | 广东润源中天生物科技有限公司 | A kind of blueberry lutein ester pressed candy and preparation method thereof |
| CN113796534A (en) * | 2021-09-15 | 2021-12-17 | 沃德绿世界(溧水)生物科技有限公司 | Blueberry lutein ester tablet, production process and equipment thereof |
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