CN109045094A - A kind of preparation method of dandelion extract - Google Patents
A kind of preparation method of dandelion extract Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention relates to a kind of preparation methods of dandelion extract, it is the following steps are included: (1), preparation raw material dandelion, impurity elimination, cleaning, dissection are crushed to 40-60 mesh, obtain dandelion powder after drying；(2), dandelion powder is weighed, it is 70%-80% ethanol solution that the 8-10 times of volume fraction measured is added into dandelion powder, and microwave power 500-600w is arranged in Microwave Extraction Apparatus, is extracted with extraction time 50-60 second, extracting solution is obtained, extracting solution is concentrated under reduced pressure into no alcohol taste and obtains concentrate；(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:(0.5-4), centrifugation obtains supernatant；(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract；This method is able to maintain the globality of dandelion substance group, keeps the consistency of drug effect.
Description
Technical field
The invention belongs to technical field of extraction of Chinese traditional medicine, and in particular to a kind of preparation method of dandelion extract.
Background technique
Dandelion is compositae plant dandelion (Taraxacum mongolicum Hand-Mazz), alkali ground dandelion
(Taraxacum borealisinese Kitam) or the drying herb for belonging to several plants.Sweet in flavor, slight bitter, it is cold in nature, it is nontoxic,
For treating pyogenic infections from tumour or sore, acute mastitis, pharyngalgia, damp and hot yellow subcutaneous ulcer, puckery pain of heat gonorrhea.Dandelion contains protein, fat, carbohydrate simultaneously
Deng having nutritive value abundant, be the Chinese medicine of dietotherapeutic.Dandelion is clinically usually used in treating acute tracheitis, urine
Road feel dye, has antitumor, Hepatoprotective cholagogue, hypoglycemic, blood fat.Due to minerals rich in, dandelion also conduct
Health care product application, for preventing anemia caused by iron deficiency；Dandelion energy skin whitening simultaneously, can be to free radical resisting to human body
Injury, strengthen immunity play the role of anti-aging.
Zhao keep instruction et al. (the dandelion chemical component such as Zhao Shouxun and pharmacological action Chinese Wild plant resources .20 (3):
1) carried out a large amount of to chemical component contained by dandelion the study found that containing taraxasterol alcohol, dandelion in radix tarxaci
Match alcohol, synanthrin, caffeic acid, palm fibre put acid, linoleic acid, linolenic acid, bitter principle B, fructose and a small amount of volatile oil and semen armeniacae amarae enzyme at
Point.In its leaf contain luteolin -7- glycoside and amino acid, spend in have taraxanthin, hair not flavine, chrysanthemum flavine, palm fibre
Eleostearic acid, linoleic acid.Meng Zhi cloud et al. (the dandelion progress People's Army medicine and pharmacology monograph .1997 such as Meng Zhiyun, 13 (2):
84) to dandelion herb the study found that its main component has: flavonoids, three mushroom classes, plant polyol class, Sesquiterpene lactones,
Coumarins, phenolic acid class, fatty acid etc..
Primary pharmacological activity ingredient includes luteolin, Quercetin, chlorogenic acid and caffeic acid etc. in dandelion.
Luteolin is a kind of natural kaempferol compound, is widely present in vegetables and fruit, as celery, west are blue
Flower, chrysanthemum, carrot, pepper, cabbage, apple skin and leaf of onion etc..In celery, green pepper, Perilla and camomile, wood
Rhinoceros grass usually exists with glycoforms.Luteolin have a variety of pharmacological activity, the plant rich in luteolin usually by with
Make Chinese medicine treatment disease.As that studies luteolin gos deep into, it is found that it has and inhibit tumor cell proliferation, induction tumour is thin
The antitumor actions such as born of the same parents' apoptosis and enhanced sensitivity anticancer drug activity, but also have anti-inflammatory, anti-oxidant and to nervous system
The effects of protection.
Dandelion is bloodroot, and modern pharmacological research finds raw containing Chelerythrine and sanguinarine etc. in dandelion
Alkaloids have following primary efficacy: 1, reducing swelling, detoxify, the function of desinsection, being used for serious case of furuncle abscess, malignant sore ulcer, scald, stubborn dermatitis etc.；
2, sanguinarine and Chelerythrine contained by dandelion extract can inhibit gram-positive bacteria to grow in vitro, to the double balls of pneumonia
Bacterium, staphylococcus aureus, hay bacillus are more sensitive, and bacteriostasis is strong compared with berberine；3 and have anti-nematode and hook end
Conveyor screw effect, can inhibit and delay the raised effect of body temperature caused by Diplococcus pneumopniae, have antibacterial solution heat function.
Quercetin is a kind of polyhydroxy flavone compound, and the entitled 3,3',4',5,7-pentahydoroxyflavone of chemistry has more
Kind biological activity and very high medical value.Quercetin is widely present in the flower, leaf, fruit of plant, it is known to more than 100 kinds
Contain Quercetin in Chinese herbal medicine, as the sophora bud, sophora flower, the root bark of tree peony, chrysanthemum, hypericum japonicum, semen plantaginis, herba taxilli, hairyvein agrimony, polygonum perfoliatum,
Gynostemma pentaphylla, hawthorn, hypericum perforatum, Semen Cuscutae, ginkgo leaf, wilsonii, oldenlandia diffusa, cockscomb, cordate houttuynia, emblic, three
White grass, Guava Leaf, matsumura leafflower herb, viola mandshurica, stringy stonecrop etc..Quercetin is not only widely distributed in nature, and pharmacology is made
With also very extensively, it has the function of anti-oxidant and removes free radical, also there is anticancer, anti-inflammatory, antibacterial, antiviral, hypoglycemic drop
Pressure, immunological regulation and cardiovascular protective effect etc..
Chlorogenic acid is the product of plant aerobic respiration metabolism, be in many Chinese medicines and fruit and vegetable it is main effectively
Ingredient has multiple biological activities, such as: cardiovascular protective effect, antioxidation, uvioresistant and radiation resistance, anti-mutagenesis
And the effect of antitumaous effect, antibacterial action, antivirus action, blood lipid-reducing blood sugar-decreasing, immunoregulation effect etc..In medicine, chemical industry and food
Equal fields all have a wide range of applications.Therefore the research and utilization of chlorogenic acid are increasingly valued by people.
Main active is luteolin, Quercetin, chlorogenic acid etc. in dandelion extract.It is therefore desirable to develop one
The preparation method of kind dandelion extract, may be implemented the high efficiency extraction of dandelion, and be easy to industrial method.
Summary of the invention
The present invention is directed to the shortcomings of the prior art, provides a kind of preparation method of dandelion extract, should
Method is able to maintain the globality of dandelion substance group, keeps the consistency of drug effect, and process conditions are simple, is easy to industry
Change, the quality of production is easy to control, and low in cost, using effect is good.
The object of the present invention is achieved in the following manner:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 40-60 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, it is 70%-80% ethanol solution that the 8-10 times of volume fraction measured is added into dandelion powder,
Microwave power 500-600w is set in Microwave Extraction Apparatus, is extracted with extraction time 50-60 second, obtains extracting solution, will extract
Liquid is concentrated under reduced pressure into no alcohol taste and obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:(0.5-4), centrifugation obtains
Clear liquid；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
According to the preparation method of above-mentioned dandelion extract, in step (2), 8 times of amounts are added into dandelion powder
Volume fraction is 75% ethanol solution, and microwave power 550w is arranged in Microwave Extraction Apparatus, was extracted, is obtained with extraction time 60 seconds
Extracting solution is obtained, extracting solution is concentrated under reduced pressure into no alcohol taste and obtains concentrate.
According to the preparation method of above-mentioned dandelion extract, in step (3), in the concentrate that step (2) obtains plus
Enter water, the mass ratio of concentrate and water is 1:2, and centrifugation obtains supernatant.
According to the preparation method of above-mentioned dandelion extract, micro-filtration filter membrane is 19 channel microfiltration membranes, internal diameter in step (4)
8mm, outer diameter 12mm, pipe range 1000mm, 0.2 μm of film average pore size, membrane material Al2O3, membrane area 0.4m2, operation pressure difference, which controls, to exist
0.01-0.2MPa。
Compared with prior art, beneficial effects of the present invention:
Operation of the present invention is easy, and the active constituent yield of extraction is high, retains the effective component of dandelion, and recovery rate is high, and moisture contains
It measures low, can make full use of raw material resources, be very suitable to industrialized production.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without creative efforts belongs to the model that the present invention protects
It encloses.
Embodiment 1:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 40 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, the volume fraction that 8 times of amounts are added into dandelion powder is 75% ethanol solution, microwave extraction
Setting microwave power 550w in instrument is taken, was extracted with extraction time 60 seconds, extracting solution is obtained, extracting solution is concentrated under reduced pressure into nothing
Alcohol taste obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:2, and centrifugation obtains supernatant；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract, micro-filtration filter membrane is 19
Channel microfiltration membranes, internal diameter 8mm, outer diameter 12mm, pipe range 1000mm, 0.2 μm of film average pore size, membrane material Al2O3, membrane area
0.4m2, operation pressure difference control is in 0.01-0.2MPa.
Embodiment 2:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 60 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, the volume fraction that 8 times of amounts are added into dandelion powder is 80% ethanol solution, microwave extraction
Setting microwave power 500w in instrument is taken, was extracted with extraction time 60 seconds, extracting solution is obtained, extracting solution is concentrated under reduced pressure into nothing
Alcohol taste obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:3, and centrifugation obtains supernatant；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
Embodiment 3:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 60 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, the volume fraction that 10 times of amounts are added into dandelion powder is 70%-80% ethanol solution, micro-
Microwave power 600w is set in wave abstraction instrument, was extracted with extraction time 50 seconds, obtains extracting solution, extracting solution is concentrated under reduced pressure
Concentrate is obtained to no alcohol taste；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:0.5, and centrifugation obtains supernatant
Liquid；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
Embodiment 4:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 40 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, the volume fraction that 8 times of amounts are added into dandelion powder is 70% ethanol solution, microwave extraction
Setting microwave power 600w in instrument is taken, was extracted with extraction time 50 seconds, extracting solution is obtained, extracting solution is concentrated under reduced pressure into nothing
Alcohol taste obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:1, and centrifugation obtains supernatant；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
Embodiment 5:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 40 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, the volume fraction that 8 times of amounts are added into dandelion powder is 80% ethanol solution, microwave extraction
Setting microwave power 500w in instrument is taken, was extracted with extraction time 50 seconds, extracting solution is obtained, extracting solution is concentrated under reduced pressure into nothing
Alcohol taste obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:3, and centrifugation obtains supernatant；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
Embodiment 6:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 40 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, the volume fraction that 8 times of amounts are added into dandelion powder is 70% ethanol solution, microwave extraction
Setting microwave power 500w in instrument is taken, was extracted with extraction time 50 seconds, extracting solution is obtained, extracting solution is concentrated under reduced pressure into nothing
Alcohol taste obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:4, and centrifugation obtains supernatant；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
Embodiment 7:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 60 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, the volume fraction that 10 times of amounts are added into dandelion powder is 70% ethanol solution, microwave extraction
Setting microwave power 600w in instrument is taken, was extracted with extraction time 50 seconds, extracting solution is obtained, extracting solution is concentrated under reduced pressure into nothing
Alcohol taste obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:2.5, and centrifugation obtains supernatant
Liquid；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
Embodiment 8:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 40 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, the volume fraction that 8 times of amounts are added into dandelion powder is 70% ethanol solution, microwave extraction
Setting microwave power 600w in instrument is taken, was extracted with extraction time 56 seconds, extracting solution is obtained, extracting solution is concentrated under reduced pressure into nothing
Alcohol taste obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:2, and centrifugation obtains supernatant；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
Embodiment 9:
The present invention provides a kind of preparation method of dandelion extract, it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 60 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, the volume fraction that 8 times of amounts are added into dandelion powder is 70% ethanol solution, microwave extraction
Setting microwave power 580w in instrument is taken, was extracted with extraction time 53 seconds, extracting solution is obtained, extracting solution is concentrated under reduced pressure into nothing
Alcohol taste obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:3.5, and centrifugation obtains supernatant
Liquid；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
What has been described above is only a preferred embodiment of the present invention, it is noted that for those skilled in the art,
Without depart from that overall concept of the invention, several changes and improvements can also be made, while the product is from dairy products angle
Belong to modulation cream series, is the one kind for modulating newborn milk powder, these also should be considered as protection scope of the present invention.
Claims (4)
1. a kind of preparation method of dandelion extract, it is characterised in that it the following steps are included:
(1), prepare raw material dandelion, impurity elimination is cleaned, and dissection is crushed to 40-60 mesh, obtains dandelion powder after drying；
(2), dandelion powder is weighed, it is 70%-80% ethanol solution that the 8-10 times of volume fraction measured is added into dandelion powder,
Microwave power 500-600w is set in Microwave Extraction Apparatus, is extracted with extraction time 50-60 second, obtains extracting solution, will extract
Liquid is concentrated under reduced pressure into no alcohol taste and obtains concentrate；
(3), it is added water in the concentrate that step (2) obtains, the mass ratio of concentrate and water is 1:(0.5-4), centrifugation obtains
Clear liquid；
(4), the supernatant that step (3) obtains is entered into progress micro-filtration in microfiltration membranes and obtains dandelion extract.
2. the preparation method of dandelion extract according to claim 1, it is characterised in that in step (2), to dandelion
The volume fraction that 8 times of amounts are added in powder is 75% ethanol solution, microwave power 550w is arranged in Microwave Extraction Apparatus, when extracting
Between extract within 60 seconds, obtain extracting solution, extracting solution is concentrated under reduced pressure into no alcohol taste and obtains concentrate.
3. the preparation method of dandelion extract according to claim 1, it is characterised in that in step (3), in step (2)
It is added water in obtained concentrate, the mass ratio of concentrate and water is 1:2, and centrifugation obtains supernatant.
4. the preparation method of dandelion extract according to claim 1, it is characterised in that: micro-filtration filter membrane in step (4)
For 19 channel microfiltration membranes, internal diameter 8mm, outer diameter 12mm, pipe range 1000mm, 0.2 μm of film average pore size, membrane material Al2O3, membrane area
0.4m2, operation pressure difference control is in 0.01-0.2MPa.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112471509A (en) * | 2020-11-25 | 2021-03-12 | 梧州学院 | Loranthus parasiticus syrup with high quercetin content and preparation method thereof |
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|---|---|---|---|---|
| EP2444098A1 (en) * | 2009-06-16 | 2012-04-25 | Livzon Pharmaceutical Group Inc. | Traditional chinese medicine composition for treating swine influenza, preparation method and use thereof |
| CN106109526A (en) * | 2016-06-27 | 2016-11-16 | 赣州华汉生物科技有限公司 | A kind of Herba Taraxaci extract and preparation method and application |
| CN107998166A (en) * | 2017-12-26 | 2018-05-08 | 湖南知达医药科技有限公司 | The preparation method of dandelion extract |
-
2018
- 2018-08-27 CN CN201810981385.2A patent/CN109045094A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2444098A1 (en) * | 2009-06-16 | 2012-04-25 | Livzon Pharmaceutical Group Inc. | Traditional chinese medicine composition for treating swine influenza, preparation method and use thereof |
| CN106109526A (en) * | 2016-06-27 | 2016-11-16 | 赣州华汉生物科技有限公司 | A kind of Herba Taraxaci extract and preparation method and application |
| CN107998166A (en) * | 2017-12-26 | 2018-05-08 | 湖南知达医药科技有限公司 | The preparation method of dandelion extract |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112471509A (en) * | 2020-11-25 | 2021-03-12 | 梧州学院 | Loranthus parasiticus syrup with high quercetin content and preparation method thereof |
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Application publication date: 20181221 |