CN109044902A - A kind of lamp-dish flower acetic toothpaste and its application - Google Patents
A kind of lamp-dish flower acetic toothpaste and its application Download PDFInfo
- Publication number
- CN109044902A CN109044902A CN201810941213.2A CN201810941213A CN109044902A CN 109044902 A CN109044902 A CN 109044902A CN 201810941213 A CN201810941213 A CN 201810941213A CN 109044902 A CN109044902 A CN 109044902A
- Authority
- CN
- China
- Prior art keywords
- lamp
- dish flower
- flower acetic
- toothpaste
- stem cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of lamp-dish flower acetic toothpaste, component includes lamp-dish flower acetic, chonglou saponin I, smelly ginseng water extract, functional additive, other additives, the lamp-dish flower acetic, chonglou saponin I, the mass ratio of smelly ginseng water extract is 6:4:3, and the concentration of the smelly ginseng water extract is 0.2g/mL.Lamp-dish flower acetic is used for the treatment and prevention of periodontitis, protects the complete of parodontium, improve the living environment of periodontal ligament stem cell and promotes its survival, enhance the proliferative capacity of periodontal ligament stem cell and promote its Osteoblast Differentiation.With good effect.
Description
Technical field
The present invention relates to a kind of daily necessities, and in particular to a kind of lamp-dish flower acetic toothpaste.
Background technique
The tooth of the mankind can only secondary teeth, it is very of short duration at a distance of several years from deciduous teeth to permanent teeth.Permanent teeth will bear all one's life chewing
Burden, tooth wear caused by tooth inevitably occurs because of chewing shortens, chase occurs, crack occurs, crackle reaches dentine depths
And at dental pulp, some Tooth root fractures.Especially after the middle age, because chewing, liking to eat the originals such as acidic food, horizontal teeth brushing way be improper
Cause be easy to cause the wedge-shaped defect of tooth, the deep 1-3mm having.Above several hard tooth tissue diseases, are to cause loss of tooth function
The main reason for energy, influence daily life.
Toothpaste is developed from commonly cleaning the teeth type to health-care hospital type, such as bioactivity glass toothpaste, strontium chloride tooth paste, anti-mistake
Quick type toothpaste and all kinds of Chinese herbal toothpastes, but they all do not have the effect of repairing injury of teeth.
Breviscapinun is from medicinal plants in China compositae plant erigeron breviscapus Erigerinbreviscapus (Vant.)
Hand.-Mazz. the flavonoids mixture extracted in has the function of activating microcirculation and removing stasis medicinal, expelling cold and relieving exterior syndrome, relaxing tendons and activating collaterals and dispelling wind and eliminating dampness
Effect is clinically usually used in treating cardiovascular and cerebrovascular disease.Lamp-dish flower acetic, also known as wild scutellaria glycosides, is the main component of Breviscapinun,
It is also main pharmacodynamics ingredient.Modern pharmacological studies have shown that lamp-dish flower acetic has expansion blood vessel, increases arterial flow, reduces blood
Liquid viscosity reduces the effects of peripheral resistance, reduction platelet count and inhibition platelet aggregation, therefore is mainly used for controlling in clinic
Treat coronary heart diseases and angina pectoris, treating myocardial ischemia damage and cerebral thrombosis.Current research report, lamp-dish flower acetic can weaken H2O2 -It lures
The cytotoxicity led weakens the intracellular accumulation (ROS) and Ca of active oxygen particle2+, and reduce have the thin of neuroprotection
The reaction of born of the same parents' mechanism oil peroxidation, the loss of mitochondrial membrane potential (MMP) and DNA.In addition, lamp-dish flower acetic energy selective induction
The death of human rectum's cancer cell shows special Pycnorus cinnabarius.But due to the water solubility and rouge of lamp-dish flower acetic
Dissolubility is all poor, and the absolute bioavailability of lamp-dish flower acetic drug oral preparation is very low, and the duration is short in the circulatory system.
Currently, there is no the researchs that lamp-dish flower acetic is used for otherwise treatment to report.
Summary of the invention
The present invention provides a kind of lamp-dish flower acetic toothpaste, treatment and prevention for periodontitis and anti-inflammatory, anti-oxidant
Aspect has good effect.Specific technical solution is as follows:
A kind of lamp-dish flower acetic toothpaste, component include lamp-dish flower acetic, chonglou saponin I, smelly ginseng water extract, functional additive,
Other additives, the lamp-dish flower acetic, chonglou saponin I, the mass ratio of smelly ginseng water extract is 6:4:3, and the smelly ginseng water extracts
The concentration of object is 0.2g/mL.
It may further be preferable that the functional additive is proline 5mg/g, 3 recombinant protein of people TGF β, 2 μ g/g, dimension life
Plain c10mg/g.
It may further be preferable that other described additives are orange concentrated extract, mint extract.
A kind of application of lamp-dish flower acetic toothpaste in anti-inflammatory, anti-oxidant and periodontitis treatment and prevention, feature
It is, the mechanism of action is the complete of protection parodontium, improves the living environment of periodontal ligament stem cell and promotes its survival, enhancing
The proliferative capacity of periodontal ligament stem cell simultaneously promotes its Osteoblast Differentiation.
Lamp-dish flower acetic is used for the treatment and prevention of periodontitis by lamp-dish flower acetic toothpaste provided by the invention, protects tooth
Complete, the proliferative capacity for improving the living environment of periodontal ligament stem cell and promoting its survival, enhancing periodontal ligament stem cell of all films
And promote its Osteoblast Differentiation.With good effect.
Detailed description of the invention
Fig. 1 is antiphlogistic effects experimental result data figure；
Fig. 2 is periodontium repairing effect experimental result data figure；
Fig. 3 is periodontal ligament stem cell survival condition experimental result data figure；
Fig. 4 is to facilitate bone differentiation schematic diagram to periodontal ligament stem cell；
Fig. 5 is to facilitate bone differentiation experimental result data figure to periodontal ligament stem cell.
Specific embodiment
Embodiment 1:
A kind of lamp-dish flower acetic toothpaste, component include lamp-dish flower acetic, chonglou saponin I, smelly ginseng water extract, functional additive,
Other additives, the lamp-dish flower acetic, chonglou saponin I, the mass ratio of smelly ginseng water extract is 6:4:3, and the smelly ginseng water extracts
The concentration of object is 0.2g/mL.
It may further be preferable that the functional additive is proline 5mg/g, 3 recombinant protein of people TGF β, 2 μ g/g, dimension life
Plain c10mg/g.
It may further be preferable that other described additives are orange concentrated extract, mint extract.
A kind of application of lamp-dish flower acetic toothpaste in anti-inflammatory, anti-oxidant and periodontitis treatment and prevention, feature
It is, the mechanism of action is the complete of protection parodontium, improves the living environment of periodontal ligament stem cell and promotes its survival, enhancing
The proliferative capacity of periodontal ligament stem cell simultaneously promotes its Osteoblast Differentiation.
Toothpaste efficiency experiment detection:
SD rat prepares Periodontitis Model (porphyromonas gingivalis synodontia neck silk thread desmurgia).Mainly matched using this toothpaste
Square solution is rinsed rat oral cavity, and each 1 time of morning and evening, for 2 weeks daily.Normal group, Periodontitis Model pair are set simultaneously
According to group, following detections are carried out:
1, antiphlogistic effects:
Collect rat oral secretion, ELISA method detection inflammatory factor MMP1, TNF α, the expression of IL1 β.Experimental result is shown in
Fig. 1.
2, periodontium repairing effect.
Rat periodontium is collected, Western Blot detects BMP2 albumen (the reparation situation of reaction periodontium) expression
Experimental result is shown in Fig. 2 for situation.
3, parodontium is collected, limited clonal dilutions method detects periodontal ligament stem cell survival condition.Experimental result is shown in Fig. 3.
4, bone differentiation is facilitated to periodontal ligament stem cell:
In vitro culture Periodontal ligament stem cell, and carry out STRO1 immunofluorescence dyeing identification.Experimental result is shown in Fig. 4.
The basal medium containing the above-mentioned formula factor is added, carries out Fiber differentiation, 2 weeks hystazarin red colourings simultaneously detect cell
The expression of middle ALP observes cell Osteoblast Differentiation.Experimental result is shown in Fig. 5.
Claims (4)
1. a kind of lamp-dish flower acetic toothpaste, which is characterized in that its component includes lamp-dish flower acetic, chonglou saponin I, and smelly ginseng water mentions
Object, functional additive, other additives, the lamp-dish flower acetic, chonglou saponin I, the mass ratio of smelly ginseng water extract is 6:4:3,
The concentration of the smelly ginseng water extract is 0.2g/mL.
2. a kind of lamp-dish flower acetic toothpaste as described in claim 1, which is characterized in that the functional additive is proline
5mg/g, 3 recombinant protein of people TGF β 2 μ g/g, vitamin c 10mg/g.
3. a kind of lamp-dish flower acetic toothpaste as claimed in claim 1 or 2, it is characterised in that other described additives are that orange is dense
Contracting extract, mint extract.
4. a kind of lamp-dish flower acetic toothpaste as claimed in claim 3 is in anti-inflammatory, anti-oxidant and periodontitis treatment and prevention
On application, which is characterized in that its mechanism of action be protect parodontium it is complete, improve the living environment of periodontal ligament stem cell simultaneously
Promote its survival, enhance the proliferative capacity of periodontal ligament stem cell and promote its Osteoblast Differentiation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810941213.2A CN109044902A (en) | 2018-08-17 | 2018-08-17 | A kind of lamp-dish flower acetic toothpaste and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810941213.2A CN109044902A (en) | 2018-08-17 | 2018-08-17 | A kind of lamp-dish flower acetic toothpaste and its application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109044902A true CN109044902A (en) | 2018-12-21 |
Family
ID=64686381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810941213.2A Pending CN109044902A (en) | 2018-08-17 | 2018-08-17 | A kind of lamp-dish flower acetic toothpaste and its application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109044902A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009154396A3 (en) * | 2008-06-17 | 2010-03-25 | Pharmapex Co., Ltd. | Sustained releasing preparation comprising a crude drug extract for preventing moisturization and controlled release |
| CN101972220A (en) * | 2010-10-28 | 2011-02-16 | 深圳智慧天使投资有限公司 | Medicated toothpaste |
| KR101919616B1 (en) * | 2011-07-07 | 2018-11-16 | 주식회사 알엔에스 | skin whitening agent |
-
2018
- 2018-08-17 CN CN201810941213.2A patent/CN109044902A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009154396A3 (en) * | 2008-06-17 | 2010-03-25 | Pharmapex Co., Ltd. | Sustained releasing preparation comprising a crude drug extract for preventing moisturization and controlled release |
| CN101972220A (en) * | 2010-10-28 | 2011-02-16 | 深圳智慧天使投资有限公司 | Medicated toothpaste |
| KR101919616B1 (en) * | 2011-07-07 | 2018-11-16 | 주식회사 알엔에스 | skin whitening agent |
Non-Patent Citations (4)
| Title |
|---|
| 叶萌: "《预防和治疗心脑血管病的天赐良药》", 30 June 2007, 云南科技出版社 * |
| 张金渝: "《重楼生产加工适宜技术》", 31 March 2018, 中国医药科技出版社 * |
| 李秀: "《云南普洱药膳植物》", 31 December 2012, 云南大学出版社 * |
| 王海燕: "中草药制剂治疗正畸患者牙移动时期牙周组织重建临床效果", 《临床心身疾病杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102512344B (en) | Blumea balsamifera extract, preparation method and application thereof in oral care and clean product | |
| KR100761660B1 (en) | A composition for promoting hair growth | |
| KR101704589B1 (en) | Composition comprising extracts of Magnolia flower and Magnolia officinlis for preventing or treating periodentitis as an active ingredient | |
| TW200948391A (en) | Agents for maturing, normalizing or stabilizing blood vessels and wrinkle-preventing and improving agents | |
| KR20190000955A (en) | Composition for preventing or treating periodontal disease comprising extracts of herbal mixture | |
| KR100970126B1 (en) | Method of preparing?compositions for preventing depilation and for promoting hair-growing | |
| JP5294536B2 (en) | Gingival epithelial cell spreading inhibitor | |
| CN109044902A (en) | A kind of lamp-dish flower acetic toothpaste and its application | |
| KR20170000491A (en) | Antiinflammable composition comprising extracts of Salvia plebeia, Ulmus davidiana, Clerodendrum trichotomum and Eleutherococcus senticosus as active ingredient | |
| JP6608071B2 (en) | Pharmaceutical composition for promoting periodontal tissue growth and preventing and treating periodontitis, comprising as an active ingredient a magnolia flower extract, a fraction thereof, or a compound isolated therefrom | |
| KR20030079075A (en) | Composition promoting hair growth and use thereof | |
| KR102241282B1 (en) | Composition for hard tissue formation and, dentin or pulp regeneration containing Ixeris dentata extract and its active compound | |
| JP4921763B2 (en) | An agent for periodontal disease containing an extract of a willow plant | |
| KR20170133820A (en) | Composition for relieving menopausal symptom or osteoporosis | |
| CN110496165A (en) | A kind of Chinese medicine composition for treating periodontitis | |
| RU2618889C1 (en) | Mouthwash agent having antiinflammatory, antimicrobial, wound-healing effect | |
| KR102093826B1 (en) | Pharmaceutical composition for preventing or treating of periodontal ligament diseases comprising spirulina extract as an active ingredient | |
| CN107375439A (en) | A kind of spray for treating canker sore and preparation method thereof | |
| CN102552780A (en) | Spray for treating simple gingivitis | |
| KR102129409B1 (en) | Composition for treating hair loss and promoting hair growth | |
| CN114712415B (en) | Radix scutellariae, honeysuckle and pseudo-ginseng composition with functions of repairing dental ulcer and stopping bleeding | |
| KR101768271B1 (en) | Composition for the prevention or treatment of periodontal disease comprising extract of Siegesbeckiae herbs | |
| KR102240841B1 (en) | Composition for inhibiting osteoclast proliferation comprising abalone hydrolysates | |
| JP2006282562A (en) | Agent for periodontosis compounded with aesculus hippocastanum l. extract component | |
| CN106619346A (en) | Gingiva-protecting toothpaste |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181221 |
|
| RJ01 | Rejection of invention patent application after publication |