CN109043136A - A kind of compound Echinacea extraction pulvis improving animal disease resistant power - Google Patents
A kind of compound Echinacea extraction pulvis improving animal disease resistant power Download PDFInfo
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- CN109043136A CN109043136A CN201810806105.4A CN201810806105A CN109043136A CN 109043136 A CN109043136 A CN 109043136A CN 201810806105 A CN201810806105 A CN 201810806105A CN 109043136 A CN109043136 A CN 109043136A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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Abstract
The present invention relates to a kind of compound Echinaceas for improving animal disease resistant power to extract pulvis, it is grouped as by the group of following parts by weight: 60-75 parts of Echinacea Purpurea Herb P.E, 5-15 parts of lipase, 5-15 parts of glucose oxidase, 5-15 parts of bacillus subtilis, the compound Echinacea extracts pulvis being capable of antiviral, enhancing animal immunizing power, the illness probability of animal is substantially reduced, while component is simple, preparation is convenient, and many animals can be suitable for, there is very extensive applicability.
Description
Technical field
The invention belongs to animal feed additive fields, and in particular to it is a kind of improve animal disease resistant power compound Echinacea mention
Take pulvis.
Background technique
During modern livestock and poultry cultivation, in order to prevent and treat Animal diseases, antibiotic etc. is often added in animal feed
To reduce the diseases such as the Expectancy of animal, such as diarrhea, flu, pneumonia, nephrosis.But the use of excessive antibiotic can destroy
After the taste of animal meat product causes antibiotics of animal drug resistance to enhance, and meat products is eaten by human body, people can be seriously affected
The treatment of class disease, is detrimental to health.Therefore, as food safety requirements are higher and higher, use is safe, noresidue, efficiently
Feed addictive come improve animal immunity become new technical need.
Meanwhile existing animal feed additive the problem of there is also restricted applications, such as chicken, duck are effectively added
Add agent, it is then general to the effect of other animals, therefore, it is also desirable to research and develop a kind of wider feed addition of the animal scope of application
Agent.
Summary of the invention
It is an object of the invention to new technical need, provide a kind of raising animal in view of the above shortcomings of the prior art
The compound Echinacea of premunition extracts pulvis, the compound Echinacea extract pulvis can antiviral, enhancing animal immunizing power, greatly
The big illness probability for reducing animal, while component is simple, preparation is convenient, and can be suitable for many animals such as pig, chicken, duck,
With very extensive applicability.
The technical scheme of the present invention is realized as follows: a kind of compound Echinacea for improving animal disease resistant power extracts pulvis,
It is grouped as by the group of following parts by weight: 60-75 parts of Echinacea Purpurea Herb P.E, 5-15 parts of lipase, 5-15 parts of glucose oxidase, withered
Careless bacillus 5-15 parts.
As a preferred solution of the present invention, the compound Echinacea extracts pulvis and is grouped as by the group of following parts by weight: purple
70 parts of chrysanthemum extract, 10 parts of lipase, 10 parts of glucose oxidase, 10 parts of bacillus subtilis of cone.
As a preferred solution of the present invention, the compound Echinacea extract pulvis the preparation method comprises the following steps: Echinacea is crushed,
With 50%~70% hydrous ethanol through ultrasonic wave extraction twice, 1~2 hour every time, filtrate was concentrated to give medicinal extract, it is dry after powder
It is broken, obtain Echinacea Purpurea Herb P.E.
As a preferred solution of the present invention, the compound Echinacea extracts the viable bacteria content of the bacillus subtilis in pulvis
>=200 hundred million cfu/g.
As a preferred solution of the present invention, the compound Echinacea extracts glucose oxidase >=100,000 U/g in pulvis.
As a preferred solution of the present invention, the compound Echinacea extract pulvis the preparation method is as follows:
(1) Echinacea extracts pulvis and sieves with 100 mesh sieve, other raw materials cross 80 meshes；
(2) glucose oxidase and the bacillus subtilis of full dose are taken, is uniformly mixed, the lipase that full dose is then added is mixed
It closes uniform；
(3) Echinacea Purpurea Herb P.E of 1/2 amount is added, is uniformly mixed, the Echinacea Purpurea Herb P.E mixing for being eventually adding surplus is equal
It is even to get.
Compound Echinacea of the present invention extracts pulvis and applies in the feed addictive that preparation improves animal immunizing power.
Beneficial effects of the present invention are as follows:
In the present invention, in Echinacea Purpurea Herb P.E main component Cichoric acid be caffeic acid derivative, have enhancing immune function,
It is movable can to stimulate immune system cell, and can inhibit hyaluronidase for anti-inflammatory effect, protects collagen III from that can lead
The influence of the free radical of degradation is caused, while Cichoric acid also has antiviral activity.
The digestive utilization ratio of grease can be improved in feeding lipase, meets the needs of animal is to high-energy diet, supplements cub
Because digestive function it is not yet physically well developed caused by endogenous digestive enzyme activity and secretory volume deficiency, reduce animal because high-fat
Indigestion and caused by trophism diarrhea, reduce the additive amount of grease, reduce feed cost, improve food conversion ratio.
Glucose oxidase (GOD) can effectively improve breeding performonce fo animals: 1) generating hydrogen peroxide, kill, inhibit cause of disease
Bacterium；2) gluconic acid, glucolactone are generated, enteron aisle acidity is reduced, beneficial bacterium is proliferated, ferments through enterobacteriaceae, gluconic acid
Through enteron aisle microflora fermentation, short chain fatty acids are generated, further decrease enteron aisle acidity, and energize for enterocyte；3) degrading microorganism
Toxin, such as aflatoxins are removed in vivo, especially virulence factor in enteron aisle, optimize intestinal environment, improve appetite, and increase is adopted
Appetite, substitute antibiotics and probiotic protect immune system, enhance liver function, reduce medicament residue in animal body, improve poultry
Product quality.
Bacillus subtillis can not only treat the diarrhoeal diseases of animal, and cure rate is high compared with Enrofloxacin and mequindox,
The diarrhoeal diseases of animal can be treated with substitute antibiotics, meanwhile, bacillus subtilis is added in animal diets, it can be significant
The gaining effect of young animal is improved, feed conversion rate is improved, improves the disease resistance of young animal, significantly reduces young animal
Diarrhea rate.
The present invention is acted on by the coordination with the synthesis of above-mentioned raw materials component, can
(1) the intracorporal gastrointestinal tract environment of animal is adjusted, the digestion and absorption of nutriment in animal body are improved, balances animal
Bacterial community in gastrointestinal tract body improves efficiency of feed utilization；
(2) interior free yl is removed, it is anti-oxidant, the immune level of animal body is improved, promotes animal development, significantly improves
Premunition；
(3) component is simple, significant in efficacy, and is suitable for a variety of livestock and poultry animals, and use scope is wide, and application is strong.
Specific embodiment
Form by the following examples is extracted pulvis and preparation method thereof to compound Echinacea of the present invention and is made into one
The detailed description of step, but the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below, it is all to be based on this hair
The technology that bright above content is realized all belongs to the scope of the present invention.
Comparative example 1
60 parts of Echinacea Purpurea Herb P.E, 10 parts of bacillus subtilis, 10 parts of antibacterial peptide, 10 parts of enterococcus faecium, 10 parts of yeast selenium,
Wherein Echinacea Purpurea Herb P.E is the preparation method is as follows: Echinacea is crushed, with 60% hydrous ethanol through ultrasonic wave extraction twice, often
Secondary 1 hour, filtrate was concentrated to give medicinal extract, and crushed after being dried obtains Echinacea Purpurea Herb P.E.Wherein bacillus subtilis viable bacteria content is
20000000000 cfu/g.
Above-mentioned each raw material component be uniformly mixed to get.
Comparative example 2
12 parts of lipase, 15 parts of glucose oxidase, 20 parts of wormwood powder, 20 parts of Herba portulacae powder, 20 parts of Eucommia Leaf Powder, yeast
13 parts of selenium, wherein wormwood powder, purslane powder and Eucommia Leaf Powder are the preparation method comprises the following steps: respectively crushed wormwood, purslane, folium cortex eucommiae
80 meshes to get.Wherein glucose oxidase is 100,000 U/g
Above-mentioned each raw material component be uniformly mixed to get.
Comparative example 3
60 parts of Echinacea Purpurea Herb P.E, 10 parts of lipase, 5 parts of glucose oxidase, 10 parts of yeast selenium, 10 parts of wormwood powder, horse
10 parts of bitterroot powder, wherein Echinacea Purpurea Herb P.E preparation method is prepared according to 1 the method for comparative example, wormwood powder and purslane
Powder is prepared according to 2 the method for comparative example.Glucose oxidase is 100,000 U/g.
Above-mentioned each raw material component be uniformly mixed to get.
Comparative example 4
60 parts of Echinacea Purpurea Herb P.E, 5 parts of bacillus subtilis, 10 parts of glucose oxidase, 5 parts of yeast cell wall, dung intestines
10 parts of coccus, 10 parts of ginsenoside, wherein Echinacea Purpurea Herb P.E preparation method is prepared according to 1 the method for comparative example, Portugal
Grape carbohydrate oxidase is 100,000 U/g, and bacillus subtilis viable bacteria content is 20,000,000,000 cfu/g.
Above-mentioned each raw material component be uniformly mixed to get.
Embodiment 1
60 parts of Echinacea Purpurea Herb P.E, 15 parts of lipase, 5 parts of glucose oxidase, 15 parts of bacillus subtilis, wherein purple cone
Chrysanthemum method for preparing extractive is as follows: Echinacea is crushed, with 50% hydrous ethanol through ultrasonic wave extraction twice, 2 hours every time,
Filtrate is concentrated to give medicinal extract, and crushed after being dried obtains Echinacea Purpurea Herb P.E, and wherein bacillus subtilis viable bacteria content is 10,000,000,000
Cfu/g, glucose oxidase are 50,000 U/g.
The preparation method comprises the following steps:
(1) all raw materials cross 80 meshes；
(2) glucose oxidase and the bacillus subtilis of full dose are taken, is uniformly mixed, the lipase that full dose is then added is mixed
It closes uniform；
(3) be added full dose Echinacea Purpurea Herb P.E, be uniformly mixed to get.
Embodiment 2
75 parts of Echinacea Purpurea Herb P.E, 5 parts of lipase, 15 parts of glucose oxidase, 5 parts of bacillus subtilis, wherein purple cone
Chrysanthemum method for preparing extractive is as follows: Echinacea is crushed, with 60% hydrous ethanol through ultrasonic wave extraction twice, 1.5 is small every time
When, filtrate is concentrated to give medicinal extract, and crushed after being dried obtains Echinacea Purpurea Herb P.E, and wherein bacillus subtilis viable bacteria content is 10,000,000,000
Cfu/g, glucose oxidase are 50,000 U/g.
The preparation method comprises the following steps:
(1) all raw materials cross 80 meshes；
(2) glucose oxidase and the bacillus subtilis of full dose are taken, is uniformly mixed, the lipase that full dose is then added is mixed
It closes uniform；
(3) Echinacea Purpurea Herb P.E of 1/4 amount is added, is uniformly mixed, then adds the Echinacea Purpurea Herb P.E of 3/4 amount, mixes
Close uniformly to get.
Embodiment 3
70 parts of Echinacea Purpurea Herb P.E, 10 parts of lipase, 10 parts of glucose oxidase, 10 parts of bacillus subtilis, wherein purple
Cone chrysanthemum method for preparing extractive it is as follows: Echinacea is crushed, with 70% hydrous ethanol through ultrasonic wave extraction twice, 1 is small every time
When, filtrate is concentrated to give medicinal extract, and crushed after being dried obtains Echinacea Purpurea Herb P.E, and wherein bacillus subtilis viable bacteria content is 20,000,000,000
Cfu/g, glucose oxidase are 100,000 U/g.
The preparation method comprises the following steps:
(1) Echinacea extracts pulvis and sieves with 100 mesh sieve, other raw materials cross 80 meshes；
(2) glucose oxidase and the bacillus subtilis of full dose are taken, is uniformly mixed, the lipase that full dose is then added is mixed
It closes uniform；
(3) Echinacea Purpurea Herb P.E of 1/2 amount is added, is uniformly mixed, the Echinacea Purpurea Herb P.E mixing for being eventually adding surplus is equal
It is even to get.
Embodiment 4
70 parts of Echinacea Purpurea Herb P.E, 10 parts of lipase, 10 parts of glucose oxidase, 10 parts of bacillus subtilis, wherein purple
Cone chrysanthemum method for preparing extractive it is as follows: Echinacea is crushed, with 70% hydrous ethanol through ultrasonic wave extraction twice, 1 is small every time
When, filtrate is concentrated to give medicinal extract, and crushed after being dried obtains Echinacea Purpurea Herb P.E, and wherein bacillus subtilis viable bacteria content is 30,000,000,000
Cfu/g, glucose oxidase are 200,000 U/g.
The preparation method comprises the following steps:
(4) Echinacea extracts pulvis and sieves with 100 mesh sieve, other raw materials cross 80 meshes；
(5) glucose oxidase and the bacillus subtilis of full dose are taken, is uniformly mixed, the lipase that full dose is then added is mixed
It closes uniform；
(6) Echinacea Purpurea Herb P.E of 1/2 amount is added, is uniformly mixed, the Echinacea Purpurea Herb P.E mixing for being eventually adding surplus is equal
It is even to get.
Using effect experiment
Comparative example 1~4 and Examples 1 to 4 feed addictive test the using effect of sucking pig.
Healthy sucking pig 160 is selected, 8 groups is divided into, gives above-mentioned feed respectively during normal feeding for every group and add
Add agent (1T complete feed adds 200g feed addictive), feeding 30 days, records the diarrhea rate of each group sucking pig, as a result see the table below.
| Grouping | Diarrhea rate |
| Comparative example 1 | 12.5% |
| Comparative example 2 | 15% |
| Comparative example 3 | 18.75% |
| Comparative example 4 | 16.25% |
| Embodiment 1 | 3.75% |
| Embodiment 2 | 3.75% |
| Embodiment 3 | 2.5% |
| Embodiment 4 | 0% |
Comparative example 1~4 and Examples 1 to 4 feed addictive test the using effect of chick.
The Broiler chicks for selecting 400 1 ages in days of health, are equally divided into 8 groups, give above-mentioned feed addictive (1T full price respectively
Feed addition 200g feed addictive), it feeding 60 days, then takes a blood sample, measurement bursal index, index and spleen index and thymus index,
As a result it see the table below.
| Grouping | Bursal index | Index and spleen index | Thymus index |
| Comparative example 1 | 0.057±0.002 | 0.143±0.002 | 0.329±0.008 |
| Comparative example 2 | 0.064±0.002 | 0.114±0.008 | 0.358±0.006 |
| Comparative example 3 | 0.075±0.003 | 0.158±0.002 | 0.302±0.005 |
| Comparative example 4 | 0.042±0.002 | 0.123±0.006 | 0.381±0.002 |
| Embodiment 1 | 0.107±0.002 | 0.221±0.003 | 0.504±0.004 |
| Embodiment 2 | 0.133±0.003 | 0.196±0.005 | 0.511±0.002 |
| Embodiment 3 | 0.124±0.002 | 0.243±0.002 | 0.527±0.002 |
| Embodiment 4 | 0.152±0.002 | 0.266±0.003 | 0.568±0.002 |
As a result as it can be seen that the effect that the feed addictive of Examples 1 to 4 improves premunition is much better than comparative example 1~4,
The diarrhea rate of sucking pig significantly reduces, and the immune organ index of Broiler chicks is more excellent.
In addition, feed addictive of the invention is tested also directed to many animals such as duck, sheep, oxen, premunition is improved
Effect clearly, it was demonstrated that use scope of the invention is very wide, have extremely strong applicability.
Claims (7)
1. a kind of compound Echinacea for improving animal disease resistant power extracts pulvis, which is characterized in that be grouped by the group of following parts by weight
At: 60-75 parts of Echinacea Purpurea Herb P.E, 5-15 parts of lipase, 5-15 parts of glucose oxidase, 5-15 parts of bacillus subtilis.
2. the compound Echinacea according to claim 1 for improving animal disease resistant power extracts pulvis, it is characterised in that described multiple
Square Echinacea extracts pulvis and is grouped as by the group of following parts by weight: 70 parts of Echinacea Purpurea Herb P.E, 10 parts of lipase, grape is glycoxidative
10 parts of enzyme, 10 parts of bacillus subtilis.
3. the compound Echinacea according to claims 1 and 2 for improving animal disease resistant power extracts pulvis, it is characterised in that described
Echinacea Purpurea Herb P.E the preparation method is as follows: Echinacea is crushed, with 50%~70% hydrous ethanol through ultrasonic wave extraction two
Secondary, 1~2 hour every time, filtrate was concentrated to give medicinal extract, and crushed after being dried obtains Echinacea Purpurea Herb P.E.
4. the compound Echinacea according to claims 1 and 2 for improving animal disease resistant power extracts pulvis, it is characterised in that described
The viable bacteria content of bacillus subtilis >=20,000,000,000 cfu/g.
5. the compound Echinacea according to claims 1 and 2 for improving animal disease resistant power extracts pulvis, it is characterised in that described
Glucose oxidase >=100,000 U/g.
6. the compound Echinacea according to claims 1 and 2 for improving animal disease resistant power extracts pulvis, it is characterised in that described
Compound Echinacea extract pulvis the preparation method is as follows:
(1) Echinacea extracts pulvis and sieves with 100 mesh sieve, other raw materials cross 80 meshes；
(2) glucose oxidase and the bacillus subtilis of full dose are taken, is uniformly mixed, the lipase mixing that full dose is then added is equal
It is even；
(3) Echinacea Purpurea Herb P.E of 1/2 amount is added, is uniformly mixed, the Echinacea Purpurea Herb P.E for being eventually adding surplus is uniformly mixed, i.e.,
?.
7. the compound Echinacea according to claims 1 and 2 for improving animal disease resistant power extracts pulvis, it is characterised in that described
Compound Echinacea extracts application of the pulvis in the feed addictive that preparation improves animal immunizing power.
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| CN201810806105.4A CN109043136A (en) | 2018-07-20 | 2018-07-20 | A kind of compound Echinacea extraction pulvis improving animal disease resistant power |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110122698A (en) * | 2019-05-28 | 2019-08-16 | 常熟市金牧药业有限公司 | Chicken compound premix |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716164A (en) * | 2012-06-28 | 2012-10-10 | 齐鲁动物保健品有限公司 | Echinacea extract and preparation method of echinacea extract |
| CN102813064A (en) * | 2012-09-16 | 2012-12-12 | 北京翰赛柯生物科技有限公司 | Plant extract feed additive for piglets |
| CN104323043A (en) * | 2014-11-20 | 2015-02-04 | 湖北威艾彼农牧科技有限公司 | Preparation method of feed additive with functions of improving weight gain and immunity of broiler chickens |
-
2018
- 2018-07-20 CN CN201810806105.4A patent/CN109043136A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716164A (en) * | 2012-06-28 | 2012-10-10 | 齐鲁动物保健品有限公司 | Echinacea extract and preparation method of echinacea extract |
| CN102813064A (en) * | 2012-09-16 | 2012-12-12 | 北京翰赛柯生物科技有限公司 | Plant extract feed additive for piglets |
| CN104323043A (en) * | 2014-11-20 | 2015-02-04 | 湖北威艾彼农牧科技有限公司 | Preparation method of feed additive with functions of improving weight gain and immunity of broiler chickens |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110122698A (en) * | 2019-05-28 | 2019-08-16 | 常熟市金牧药业有限公司 | Chicken compound premix |
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Application publication date: 20181221 |