CN109030847A - Sampler and detection analysis instrument with the device - Google Patents

Sampler and detection analysis instrument with the device Download PDF

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Publication number
CN109030847A
CN109030847A CN201810796719.9A CN201810796719A CN109030847A CN 109030847 A CN109030847 A CN 109030847A CN 201810796719 A CN201810796719 A CN 201810796719A CN 109030847 A CN109030847 A CN 109030847A
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CN
China
Prior art keywords
sampling
fixed
specimen needle
sampler
sampling mechanism
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810796719.9A
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Chinese (zh)
Inventor
邹继华
朱磊
徐磊
陈宇迪
徐勇
冯喆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangxi Wei Shui Biotechnology Co Ltd
Original Assignee
Jiangxi Wei Shui Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangxi Wei Shui Biotechnology Co Ltd filed Critical Jiangxi Wei Shui Biotechnology Co Ltd
Priority to CN201810796719.9A priority Critical patent/CN109030847A/en
Publication of CN109030847A publication Critical patent/CN109030847A/en
Pending legal-status Critical Current

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011Control of the position or alignment of the transfer device

Abstract

The present invention provides a kind of samplers, it includes sampling mechanism, is connected and fixed mechanism, driving mechanism, and sampling mechanism, which is slidably connected to, is connected and fixed mechanism, and driving mechanism can drive sampling mechanism to slide on being connected and fixed mechanism;It further include that sampling positioning component is used to sampling mechanism being positioned at desired location;Wherein sampling positioning component is set to the other positions for being connected and fixed in mechanism and/or being set to detection analysis instrument.The present invention also provides the detection analysis instruments with above-mentioned sampler.Sampler of the invention makes sampling mechanism smooth sliding in being connected and fixed mechanism by driving mechanism, further controls sampling mechanism position to control the depth for entering sample, to realize puncture and sampled functions by sampling positioning component;Sampler through the invention samples accurate positioning, can go deep into sample bottom, be particularly suitable for needing sample liquid all taking out the testing and analysis system analyzed.

Description

Sampler and detection analysis instrument with the device
Technical field
The present invention relates to technical field of medical equipment, and in particular to a kind of inspection detection device, more particularly, to one kind point Analyse detection sampler.
Background technique
The detection of piarhemia parting is for the cholesterol level for measuring all kinds of lipoprotein, compared with the surveyed project of biochemical analysis more Specifically, in detail, it is possible to more accurately analysis sample ingredient situation.Such as it is different according to the density of lipoprotein, it can be by rouge Albumen is divided into chylomicron (CM), very low density lipoprotein (VLDL), intermediated-density lipoprotein (IDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL).Clinically conventional determining not only has total cholesterol (T-CH) at present, there are also LDL-C, HDL-C.Wherein the too high levels of LDL-C are easy to cause atherosclerosis, and HDL-C there is certain protection to make blood vessel With.But it has recently been demonstrated that either LDL-C or HDL-C all have heterogeneity, clinical meaning is also not exactly the same. As LDL-C is segmented into many subfractions, sdLDL-C (sdLDL-C), since its structure more causes It is close, it is more easier to cause atherosclerosis, also referred to as Type B, and big and light low density lipoprotein cholesterol (LLDL-C) then phase The ability of atharosclerosis is weaker than under, also known as A type.In HDL-C, it can also at least be divided into two kinds of main subgroups Point, such as big and light HDL2 particle and small and dense HDL3 particle, some research evidences have shown that the subgroup of measurement HDL The risk of cardiovascular disease can preferably be reacted than only measurement HDL by dividing.And due to for example each lipoprotein/subspecies of each ingredient Class density is different, naturally will form layering when being present in external as liquid bio sample, therefore for liquid bio sample It is very necessary completely to understand sample ingredient situation to carry out layered weighting analysis.It samples and mostly uses in existing detection and analysis instrument Hold the mode of imbibition, the fixed sampling probe of box-like specimen holder indentation is realized sampling by mechanical arm by sampler, can not to point The liquid sample sample of layer is completely tested and analyzed.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of sampler that can be punctured, sample to sample, can fit For being rounded the detection and analysis instrument of the stratified liquid of pipe.
The technical solution of the present invention is to provide a kind of sampler, including sampling mechanism, it is connected and fixed mechanism, driving machine Structure, sampling mechanism, which is slidably connected to, is connected and fixed mechanism, and driving mechanism can drive sampling mechanism sliding on being connected and fixed mechanism It is dynamic;It further include that sampling positioning component is used to sampling mechanism being positioned at desired location;Wherein sampling positioning component is set to connection On fixed mechanism and/or it is set to the other positions of detection analysis instrument.
Further, sampling mechanism is fixed on driving mechanism by link block, and sampling mechanism has at least one specimen needle, It is preferred that the setting direction of specimen needle is vertical direction, specimen needle is that detachable setting is conveniently replaceable;
Further, more specimen needle settings are capable of forming specimen needle group, and preferably four specimen needles form specimen needle group, On the one hand it can satisfy normal sampling demand, can guarantee in primary sample after on the other hand integrating specimen needle and sample channel environment Factor is as consistent as possible, reduces systematic error, improves accuracy, the reliability of detection and analysis.
Further, sampling mechanism includes specimen needle support, and specimen needle is removably mounted to specimen needle support, and specimen needle is hung down Directly in the mounting plane of specimen needle support;It further include pinboard, specimen needle support is installed on pinboard, and link block is fixed on switching Plate, pinboard plane and the mounting plane (plane that mounting plane refers to installation specimen needle) of specimen needle support are parallel to each other, and are used for Guarantee specimen needle for vertical direction setting.
Further, sampling mechanism includes sliding block, is correspondingly connected with fixed mechanism equipped with guide rail, is cooperated by sliding block and guide rail Slide sampling mechanism can on being connected and fixed structure.
Further, pinboard bottom is provided with ribs to increase pinboard intensity.
Further, being connected and fixed mechanism includes symmetrically arranged two track bases, and each track base is provided with guide rail;It takes Sample positioning component is at least one group, is set to the side of track base.
Further, sampling positioning component includes signalling means and trigger, and wherein signalling means is included at least along sampling mechanism The reset signal device and termination signal device of glide direction setting, the trigger to match therewith are set to sampling mechanism.
Further, being connected and fixed mechanism further includes fixed plate, and track base is set to fixed plate one side, and fixed plate is another Side is provided with for the linking arm fixed with detection analysis instrument.
Further, driving mechanism includes stepper motor, and ball-screw (is connected by shaft coupling) between the two, ball wire Thick stick is fixedly connected with sampling mechanism, and the pinboard of ball-screw and sampling mechanism can be connected by link block.
The advantages of the present invention: making sampling mechanism smooth sliding in being connected and fixed mechanism by driving mechanism, Sampling mechanism position is further controlled to control the depth for entering sample, to realize puncture and sampling by sampling positioning component Function;Sampler through the invention samples accurate positioning, can go deep into sample bottom, be particularly suitable for needing sample Liquid all takes out the testing and analysis system analyzed.
Detailed description of the invention
Fig. 1 is the positive structure diagram of inventive sampling device.
Fig. 2 is the side structure schematic view of inventive sampling device.
Fig. 3 is the overlooking structure diagram of inventive sampling device.
Fig. 4 is the inside partial structural diagram of inventive sampling device.
Appended drawing reference: 1- is connected and fixed mechanism, 11- linking arm, 12- fixed plate, 13- track base, 14- guide rail, 2- driving Mechanism, 21- stepper motor, 22- shaft coupling, 23- ball-screw, 3- link block, 4- specimen needle, 5- sliding block, 6- pinboard, 61- Ribs, 62- connecting column, 7- sample positioning component, 71- reset signal device, 72- termination signal device, 73- trigger, 8- sample Needle support
Specific embodiment
Present invention will be further explained below with reference to the attached drawings and specific embodiments.
The sampler of analysis and detecting instrument is mostly that specimen needle is fixed, by mechanical arm will be placed with the sample rack of sample to Sample needle movement is so that sample rack is pressed into specimen needle to complete to sample.To meet the position that specimen needle is accurately positioned and gos deep into sample Demand, and complete the purpose that sample is all removed, set movable for specimen needle.
The present invention provides a kind of sampler, as shown in Figures 1 to 3, including sampling mechanism, is connected and fixed mechanism 1, driving machine Structure 2, sampling mechanism, which is slidably connected to, is connected and fixed mechanism 1, and driving mechanism 2 can drive sampling mechanism being connected and fixed mechanism 1 Upper sliding;It further include that sampling positioning component 7 is used to sampling mechanism being positioned at desired location;Wherein sampling positioning component 7 is arranged In the other positions for being connected and fixed in mechanism 1 and/or being set to detection analysis instrument, such as sampling positioning component 7 includes phase interworking The signalling means and trigger of conjunction, signalling means be set to be connected and fixed mechanism 1 desired location (be set as sample position and reset position Set) on, trigger is set on sampling mechanism, and when sampling mechanism slides on being connected and fixed mechanism 1, trigger moves therewith And in desired location trigger signal device, signalling means, which issues to instruct therewith, makes sampling mechanism stop motion, after specific action to be done Host computer (issuing the mechanism of operational order, be not shown in the figure) order-driven mechanism 2 of sampling mechanism drives sampling mechanism again Movement.
In further improved embodiment, the signalling means of sampling positioning component 7 includes setting along sampling mechanism glide direction It is placed in the reset signal device 71 for being connected and fixed 1 one side of mechanism, termination signal device 72, and the triggering being set on sampling mechanism Device 73, wherein signalling means can be optocoupler, optoelectronic switch etc., and reset signal device 71, termination signal device 72 are specific in the present embodiment To reset optocoupler and terminating optocoupler, the trigger 73 on the sampling mechanism to match therewith is chopper blade.It should be noted that signal Device can be set multiple, suspend the needs of completing expected movement in more multistation to meet sampling mechanism, the present embodiment and attached Be in figure briefly illustrate, and be connected and fixed mechanism 1 one side setting reset signal device and termination signal device can usually expire Foot actual use needs.
In further improved embodiment, as shown in figure 4, sampling mechanism is fixed on driving mechanism 2 by link block 3; Sampling mechanism has at least one specimen needle 4, and the preferably setting direction of specimen needle 4 is sliding of the vertical direction i.e. with sampling mechanism Direction is consistent, and specimen needle 4 is that detachable setting is conveniently replaceable;
In further improved embodiment, more specimen needles 4 of setting are capable of forming specimen needle group, more 4 rows of specimen needle It is corresponded to each other at specific array, and with the arrangement for sampling this;Preferably four specimen needles 4 form specimen needle group, such as Fig. 3 institute Show;On the one hand forming specimen needle group can be improved sampling efficiency, when can guarantee sampling start-stop after on the other hand integrating specimen needle Between it is identical with position, to guarantee respectively to sample channel environment factor in primary sample as consistent as possible, reduce systematic error, improve Accuracy, the reliability of detection and analysis.
In further improved embodiment, sampling mechanism includes specimen needle support 8, and specimen needle 4 is removably mounted to sample This needle support 8, mounting means are preferably the reliability being threadedly coupled to guarantee to puncture, and specimen needle 4 is perpendicular to specimen needle support 8 Mounting plane (mounting plane that mounting plane refers to specimen needle);Sampling mechanism further includes pinboard 6, and specimen needle support 8 is installed In pinboard 6, and specimen needle support 8 can be it is detachable, 8 Whole-dismountable of specimen needle support facilitates integral replacing specimen needle, Link block 3 is fixed on pinboard 6, and the plane of pinboard 6 and the mounting plane of specimen needle support 8 are parallel to each other, for guaranteeing sample This needle is vertical direction setting.
In further improved embodiment, connected between specimen needle support 8 and pinboard 6 by more connecting columns 62, It is two connecting columns 62 in the present embodiment, and is illustrated in figure 2 relative misalignment setting, provides the premise of enough support forces meeting Under in the form of meeting specimen needle group arrangement mode arrange.
In further improved embodiment, sampling mechanism further includes sliding block 5, is correspondingly connected with fixed mechanism 1 equipped with guide rail 14, sampling mechanism is slided can on being connected and fixed structure 1 by sliding block 5 and the cooperation of guide rail 14, is sampler in the present embodiment Structure is linear slide, therefore guide rail 14 is linear guide, it should be pointed out that be that a variety of fortune can be set in difference according to actual needs Dynamic path, such as circular motion or multi-dimensional movement etc..
In further improved embodiment, 6 bottom surface of pinboard is provided with ribs to increase the intensity of pinboard 6, Enough supports are provided in 4 puncture process of specimen needle for specimen needle 4;6 side of pinboard also has a vertical plate, makes 6 shape of pinboard At inverted L-shaped, link block 3 is fixed on vertical plate.
In further improved embodiment, being connected and fixed mechanism 1 includes symmetrically arranged two track bases 13, each Track base 13 is provided with guide rail 14;It samples positioning component 7 and is at least one group (one group is two signalling means and a trigger), It is set to the lateral surface of track base 13.
In further improved embodiment, being connected and fixed mechanism 1 further includes fixed plate 12, and track base 13 is set to fixation The one side of plate 12,12 another side of fixed plate are provided with for the linking arm 11 fixed with detection analysis instrument.
In further improved embodiment, driving mechanism 2 includes stepper motor 21, ball-screw 23, preferably stepping Between motor 21 and ball-screw 23 by yielding coupling 22 couple to drive ball-screw 23 rotate, ball-screw 23 and Sampling mechanism is fixedly connected, and the pinboard 6 of ball-screw 23 and sampling mechanism is connected specifically by link block 3, therefore when rolling Ballscrew 23 will drive sampling probe 4 for linear motion when rotating, and can reach sample position and positioning resolution is higher, it is quasi- to position Really, and using yielding coupling 22 positioning accuracy can be made more controllable accurate, and by ball-screw 23 by stepper motor 21 Rotation be converted into linear motion, load is big, is easy to implement puncture function.
The present invention also provides a kind of detection analysis instrument with above-mentioned sampler, sampler is installed by linking arm 11 In in detection analysis instrument.
Detection analysis instrument with above-mentioned sampler, wherein the signalling means in sampling positioning component 7 is installed on detection point The other positions of sampler are removed in analyzer.
Above-mentioned detection analysis instrument of the invention is piarhemia parting detector, and the cholesterol for measuring all kinds of lipoprotein contains Amount.
The course of work of inventive sampling device is as follows:
When standby mode, sampling mechanism is in reset position, i.e., position as shown in Figure 2 resets optocoupler at this time and (resets letter Number device 71) it is triggered by chopper blade (trigger 73) and is in triggering state, assigning instruction when host computer makes 21 turns of stepper motor Dynamic, then stepper motor 21 drives the rotation of ball-screw 23 to be accurate to specimen needle 4 to drive sampling mechanism to move along guide rail 14 Up to sample position, optocoupler (termination signal device 72) is terminated at this time and is triggered by chopper blade (trigger 73) and is in triggering state, Sampling mechanism stop motion, and specimen needle 4 gos deep into sample bottom at this time, it is ensured that all sample liquids are flowed by specimen needle 4 Detection analysis instrument;After the completion of to be sampled, sampler resets, and sampling mechanism returns to reset position and enters standby mode, under waiting One actuation cycle.
The present embodiments relate to the material arrived, reagent and experimental facilities, are to meet inspection detection unless otherwise instructed The commercial product in field.
The above is merely a preferred embodiment of the present invention, it is noted that for those skilled in the art For, under the premise of not departing from core of the invention technology, improvements and modifications can also be made, these improvements and modifications are also answered Belong to scope of patent protection of the invention.With any change in the comparable meaning and scope of claims of the present invention, all It is considered as being included within the scope of the claims.

Claims (13)

1. sampler, which is characterized in that including sampling mechanism, be connected and fixed mechanism, driving mechanism, sampling mechanism is slidably connected In being connected and fixed mechanism, driving mechanism can drive sampling mechanism to slide on being connected and fixed mechanism;It further include sampling positioning group Part is used to sampling mechanism being positioned at desired location;Wherein sampling positioning component, which is set to, is connected and fixed in mechanism and/or detects The other positions of analyzer.
2. sampler according to claim 1, which is characterized in that the sampling mechanism is fixed on described by link block Driving mechanism, the sampling mechanism have at least one specimen needle.
3. sampler according to claim 1, which is characterized in that more arrangements of the specimen needle form specimen needle group.
4. sampler according to claim 2, which is characterized in that the sampling mechanism includes specimen needle support, described Specimen needle is removably mounted to the specimen needle support, mounting plane of the specimen needle perpendicular to the specimen needle support;Institute Stating sampling mechanism further includes pinboard, and the specimen needle support is fixedly mounted or is removably mounted to the pinboard, the company It connects block and is fixed on the pinboard, the pinboard plane and the mounting plane of specimen needle support are parallel to each other.
5. sampler according to claim 1, which is characterized in that the sampling mechanism includes sliding block, corresponding described Mechanism is connected and fixed equipped with guide rail.
6. sampler according to claim 1, which is characterized in that the mechanism that is connected and fixed includes symmetrically arranged two A track base, each track base are provided with guide rail;The sampling positioning component is at least one group, and is set to the guide rail The side of seat.
7. sampler according to claim 1, which is characterized in that the sampling positioning component includes mutually matched letter Number device and trigger, the signalling means, which includes at least reset signal device be arranged along the sampling mechanism glide direction and terminates, to be believed Number device;The set-up mode of the sampling positioning component is to be connected and fixed mechanism, the trigger described in the signalling means is set to It is set to the sampling mechanism or the signalling means is set to the other positions of detection analysis instrument, the trigger is set to The sampling mechanism.
8. sampler according to claim 1, which is characterized in that the driving mechanism includes stepper motor, ball wire Thick stick, the ball-screw are fixedly connected with the sampling mechanism;Pass through yielding coupling between the stepper motor, ball-screw Connection.
9. sampler according to claim 4, which is characterized in that the pinboard bottom is provided with ribs.
10. sampler according to claim 6, which is characterized in that the mechanism that is connected and fixed further includes fixed plate, institute It states track base and is set to the fixed plate one side, the fixed plate another side is provided with for fixed with detection analysis instrument Linking arm.
11. detection analysis instrument, which is characterized in that have the described in any item samplers of claim 1~10.
12. detection analysis instrument according to claim 11, which is characterized in that the sampler passes through solid in the connection The linking arm for determining to be arranged in mechanism is installed on detection analysis instrument.
13. detection analysis instrument according to claim 11, which is characterized in that it is piarhemia parting detector, it is each for measuring The cholesterol level of class lipoprotein.
CN201810796719.9A 2018-07-19 2018-07-19 Sampler and detection analysis instrument with the device Pending CN109030847A (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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Publications (1)

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CN109030847A true CN109030847A (en) 2018-12-18

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