CN109030847A - Sampler and detection analysis instrument with the device - Google Patents
Sampler and detection analysis instrument with the device Download PDFInfo
- Publication number
- CN109030847A CN109030847A CN201810796719.9A CN201810796719A CN109030847A CN 109030847 A CN109030847 A CN 109030847A CN 201810796719 A CN201810796719 A CN 201810796719A CN 109030847 A CN109030847 A CN 109030847A
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- sampling
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- specimen needle
- sampler
- sampling mechanism
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- 238000004458 analytical method Methods 0.000 title claims abstract description 29
- 238000001514 detection method Methods 0.000 title claims abstract description 28
- 230000007246 mechanism Effects 0.000 claims abstract description 111
- 238000005070 sampling Methods 0.000 claims abstract description 90
- 230000011664 signaling Effects 0.000 claims description 12
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 8
- 108090001030 Lipoproteins Proteins 0.000 claims description 6
- 102000004895 Lipoproteins Human genes 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 5
- 238000010168 coupling process Methods 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 7
- 238000012360 testing method Methods 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 34
- 230000033001 locomotion Effects 0.000 description 9
- 108010028554 LDL Cholesterol Proteins 0.000 description 5
- 108010023302 HDL Cholesterol Proteins 0.000 description 4
- 108010010234 HDL Lipoproteins Proteins 0.000 description 4
- 102000015779 HDL Lipoproteins Human genes 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 108010004103 Chylomicrons Proteins 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 108010062497 VLDL Lipoproteins Proteins 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000010152 Huntington disease-like 3 Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
Abstract
The present invention provides a kind of samplers, it includes sampling mechanism, is connected and fixed mechanism, driving mechanism, and sampling mechanism, which is slidably connected to, is connected and fixed mechanism, and driving mechanism can drive sampling mechanism to slide on being connected and fixed mechanism;It further include that sampling positioning component is used to sampling mechanism being positioned at desired location;Wherein sampling positioning component is set to the other positions for being connected and fixed in mechanism and/or being set to detection analysis instrument.The present invention also provides the detection analysis instruments with above-mentioned sampler.Sampler of the invention makes sampling mechanism smooth sliding in being connected and fixed mechanism by driving mechanism, further controls sampling mechanism position to control the depth for entering sample, to realize puncture and sampled functions by sampling positioning component;Sampler through the invention samples accurate positioning, can go deep into sample bottom, be particularly suitable for needing sample liquid all taking out the testing and analysis system analyzed.
Description
Technical field
The present invention relates to technical field of medical equipment, and in particular to a kind of inspection detection device, more particularly, to one kind point
Analyse detection sampler.
Background technique
The detection of piarhemia parting is for the cholesterol level for measuring all kinds of lipoprotein, compared with the surveyed project of biochemical analysis more
Specifically, in detail, it is possible to more accurately analysis sample ingredient situation.Such as it is different according to the density of lipoprotein, it can be by rouge
Albumen is divided into chylomicron (CM), very low density lipoprotein (VLDL), intermediated-density lipoprotein (IDL), low-density lipoprotein
(LDL) and high-density lipoprotein (HDL).Clinically conventional determining not only has total cholesterol (T-CH) at present, there are also LDL-C,
HDL-C.Wherein the too high levels of LDL-C are easy to cause atherosclerosis, and HDL-C there is certain protection to make blood vessel
With.But it has recently been demonstrated that either LDL-C or HDL-C all have heterogeneity, clinical meaning is also not exactly the same.
As LDL-C is segmented into many subfractions, sdLDL-C (sdLDL-C), since its structure more causes
It is close, it is more easier to cause atherosclerosis, also referred to as Type B, and big and light low density lipoprotein cholesterol (LLDL-C) then phase
The ability of atharosclerosis is weaker than under, also known as A type.In HDL-C, it can also at least be divided into two kinds of main subgroups
Point, such as big and light HDL2 particle and small and dense HDL3 particle, some research evidences have shown that the subgroup of measurement HDL
The risk of cardiovascular disease can preferably be reacted than only measurement HDL by dividing.And due to for example each lipoprotein/subspecies of each ingredient
Class density is different, naturally will form layering when being present in external as liquid bio sample, therefore for liquid bio sample
It is very necessary completely to understand sample ingredient situation to carry out layered weighting analysis.It samples and mostly uses in existing detection and analysis instrument
Hold the mode of imbibition, the fixed sampling probe of box-like specimen holder indentation is realized sampling by mechanical arm by sampler, can not to point
The liquid sample sample of layer is completely tested and analyzed.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of sampler that can be punctured, sample to sample, can fit
For being rounded the detection and analysis instrument of the stratified liquid of pipe.
The technical solution of the present invention is to provide a kind of sampler, including sampling mechanism, it is connected and fixed mechanism, driving machine
Structure, sampling mechanism, which is slidably connected to, is connected and fixed mechanism, and driving mechanism can drive sampling mechanism sliding on being connected and fixed mechanism
It is dynamic;It further include that sampling positioning component is used to sampling mechanism being positioned at desired location;Wherein sampling positioning component is set to connection
On fixed mechanism and/or it is set to the other positions of detection analysis instrument.
Further, sampling mechanism is fixed on driving mechanism by link block, and sampling mechanism has at least one specimen needle,
It is preferred that the setting direction of specimen needle is vertical direction, specimen needle is that detachable setting is conveniently replaceable;
Further, more specimen needle settings are capable of forming specimen needle group, and preferably four specimen needles form specimen needle group,
On the one hand it can satisfy normal sampling demand, can guarantee in primary sample after on the other hand integrating specimen needle and sample channel environment
Factor is as consistent as possible, reduces systematic error, improves accuracy, the reliability of detection and analysis.
Further, sampling mechanism includes specimen needle support, and specimen needle is removably mounted to specimen needle support, and specimen needle is hung down
Directly in the mounting plane of specimen needle support;It further include pinboard, specimen needle support is installed on pinboard, and link block is fixed on switching
Plate, pinboard plane and the mounting plane (plane that mounting plane refers to installation specimen needle) of specimen needle support are parallel to each other, and are used for
Guarantee specimen needle for vertical direction setting.
Further, sampling mechanism includes sliding block, is correspondingly connected with fixed mechanism equipped with guide rail, is cooperated by sliding block and guide rail
Slide sampling mechanism can on being connected and fixed structure.
Further, pinboard bottom is provided with ribs to increase pinboard intensity.
Further, being connected and fixed mechanism includes symmetrically arranged two track bases, and each track base is provided with guide rail;It takes
Sample positioning component is at least one group, is set to the side of track base.
Further, sampling positioning component includes signalling means and trigger, and wherein signalling means is included at least along sampling mechanism
The reset signal device and termination signal device of glide direction setting, the trigger to match therewith are set to sampling mechanism.
Further, being connected and fixed mechanism further includes fixed plate, and track base is set to fixed plate one side, and fixed plate is another
Side is provided with for the linking arm fixed with detection analysis instrument.
Further, driving mechanism includes stepper motor, and ball-screw (is connected by shaft coupling) between the two, ball wire
Thick stick is fixedly connected with sampling mechanism, and the pinboard of ball-screw and sampling mechanism can be connected by link block.
The advantages of the present invention: making sampling mechanism smooth sliding in being connected and fixed mechanism by driving mechanism,
Sampling mechanism position is further controlled to control the depth for entering sample, to realize puncture and sampling by sampling positioning component
Function;Sampler through the invention samples accurate positioning, can go deep into sample bottom, be particularly suitable for needing sample
Liquid all takes out the testing and analysis system analyzed.
Detailed description of the invention
Fig. 1 is the positive structure diagram of inventive sampling device.
Fig. 2 is the side structure schematic view of inventive sampling device.
Fig. 3 is the overlooking structure diagram of inventive sampling device.
Fig. 4 is the inside partial structural diagram of inventive sampling device.
Appended drawing reference: 1- is connected and fixed mechanism, 11- linking arm, 12- fixed plate, 13- track base, 14- guide rail, 2- driving
Mechanism, 21- stepper motor, 22- shaft coupling, 23- ball-screw, 3- link block, 4- specimen needle, 5- sliding block, 6- pinboard, 61-
Ribs, 62- connecting column, 7- sample positioning component, 71- reset signal device, 72- termination signal device, 73- trigger, 8- sample
Needle support
Specific embodiment
Present invention will be further explained below with reference to the attached drawings and specific embodiments.
The sampler of analysis and detecting instrument is mostly that specimen needle is fixed, by mechanical arm will be placed with the sample rack of sample to
Sample needle movement is so that sample rack is pressed into specimen needle to complete to sample.To meet the position that specimen needle is accurately positioned and gos deep into sample
Demand, and complete the purpose that sample is all removed, set movable for specimen needle.
The present invention provides a kind of sampler, as shown in Figures 1 to 3, including sampling mechanism, is connected and fixed mechanism 1, driving machine
Structure 2, sampling mechanism, which is slidably connected to, is connected and fixed mechanism 1, and driving mechanism 2 can drive sampling mechanism being connected and fixed mechanism 1
Upper sliding;It further include that sampling positioning component 7 is used to sampling mechanism being positioned at desired location;Wherein sampling positioning component 7 is arranged
In the other positions for being connected and fixed in mechanism 1 and/or being set to detection analysis instrument, such as sampling positioning component 7 includes phase interworking
The signalling means and trigger of conjunction, signalling means be set to be connected and fixed mechanism 1 desired location (be set as sample position and reset position
Set) on, trigger is set on sampling mechanism, and when sampling mechanism slides on being connected and fixed mechanism 1, trigger moves therewith
And in desired location trigger signal device, signalling means, which issues to instruct therewith, makes sampling mechanism stop motion, after specific action to be done
Host computer (issuing the mechanism of operational order, be not shown in the figure) order-driven mechanism 2 of sampling mechanism drives sampling mechanism again
Movement.
In further improved embodiment, the signalling means of sampling positioning component 7 includes setting along sampling mechanism glide direction
It is placed in the reset signal device 71 for being connected and fixed 1 one side of mechanism, termination signal device 72, and the triggering being set on sampling mechanism
Device 73, wherein signalling means can be optocoupler, optoelectronic switch etc., and reset signal device 71, termination signal device 72 are specific in the present embodiment
To reset optocoupler and terminating optocoupler, the trigger 73 on the sampling mechanism to match therewith is chopper blade.It should be noted that signal
Device can be set multiple, suspend the needs of completing expected movement in more multistation to meet sampling mechanism, the present embodiment and attached
Be in figure briefly illustrate, and be connected and fixed mechanism 1 one side setting reset signal device and termination signal device can usually expire
Foot actual use needs.
In further improved embodiment, as shown in figure 4, sampling mechanism is fixed on driving mechanism 2 by link block 3;
Sampling mechanism has at least one specimen needle 4, and the preferably setting direction of specimen needle 4 is sliding of the vertical direction i.e. with sampling mechanism
Direction is consistent, and specimen needle 4 is that detachable setting is conveniently replaceable;
In further improved embodiment, more specimen needles 4 of setting are capable of forming specimen needle group, more 4 rows of specimen needle
It is corresponded to each other at specific array, and with the arrangement for sampling this;Preferably four specimen needles 4 form specimen needle group, such as Fig. 3 institute
Show;On the one hand forming specimen needle group can be improved sampling efficiency, when can guarantee sampling start-stop after on the other hand integrating specimen needle
Between it is identical with position, to guarantee respectively to sample channel environment factor in primary sample as consistent as possible, reduce systematic error, improve
Accuracy, the reliability of detection and analysis.
In further improved embodiment, sampling mechanism includes specimen needle support 8, and specimen needle 4 is removably mounted to sample
This needle support 8, mounting means are preferably the reliability being threadedly coupled to guarantee to puncture, and specimen needle 4 is perpendicular to specimen needle support 8
Mounting plane (mounting plane that mounting plane refers to specimen needle);Sampling mechanism further includes pinboard 6, and specimen needle support 8 is installed
In pinboard 6, and specimen needle support 8 can be it is detachable, 8 Whole-dismountable of specimen needle support facilitates integral replacing specimen needle,
Link block 3 is fixed on pinboard 6, and the plane of pinboard 6 and the mounting plane of specimen needle support 8 are parallel to each other, for guaranteeing sample
This needle is vertical direction setting.
In further improved embodiment, connected between specimen needle support 8 and pinboard 6 by more connecting columns 62,
It is two connecting columns 62 in the present embodiment, and is illustrated in figure 2 relative misalignment setting, provides the premise of enough support forces meeting
Under in the form of meeting specimen needle group arrangement mode arrange.
In further improved embodiment, sampling mechanism further includes sliding block 5, is correspondingly connected with fixed mechanism 1 equipped with guide rail
14, sampling mechanism is slided can on being connected and fixed structure 1 by sliding block 5 and the cooperation of guide rail 14, is sampler in the present embodiment
Structure is linear slide, therefore guide rail 14 is linear guide, it should be pointed out that be that a variety of fortune can be set in difference according to actual needs
Dynamic path, such as circular motion or multi-dimensional movement etc..
In further improved embodiment, 6 bottom surface of pinboard is provided with ribs to increase the intensity of pinboard 6,
Enough supports are provided in 4 puncture process of specimen needle for specimen needle 4;6 side of pinboard also has a vertical plate, makes 6 shape of pinboard
At inverted L-shaped, link block 3 is fixed on vertical plate.
In further improved embodiment, being connected and fixed mechanism 1 includes symmetrically arranged two track bases 13, each
Track base 13 is provided with guide rail 14;It samples positioning component 7 and is at least one group (one group is two signalling means and a trigger),
It is set to the lateral surface of track base 13.
In further improved embodiment, being connected and fixed mechanism 1 further includes fixed plate 12, and track base 13 is set to fixation
The one side of plate 12,12 another side of fixed plate are provided with for the linking arm 11 fixed with detection analysis instrument.
In further improved embodiment, driving mechanism 2 includes stepper motor 21, ball-screw 23, preferably stepping
Between motor 21 and ball-screw 23 by yielding coupling 22 couple to drive ball-screw 23 rotate, ball-screw 23 and
Sampling mechanism is fixedly connected, and the pinboard 6 of ball-screw 23 and sampling mechanism is connected specifically by link block 3, therefore when rolling
Ballscrew 23 will drive sampling probe 4 for linear motion when rotating, and can reach sample position and positioning resolution is higher, it is quasi- to position
Really, and using yielding coupling 22 positioning accuracy can be made more controllable accurate, and by ball-screw 23 by stepper motor 21
Rotation be converted into linear motion, load is big, is easy to implement puncture function.
The present invention also provides a kind of detection analysis instrument with above-mentioned sampler, sampler is installed by linking arm 11
In in detection analysis instrument.
Detection analysis instrument with above-mentioned sampler, wherein the signalling means in sampling positioning component 7 is installed on detection point
The other positions of sampler are removed in analyzer.
Above-mentioned detection analysis instrument of the invention is piarhemia parting detector, and the cholesterol for measuring all kinds of lipoprotein contains
Amount.
The course of work of inventive sampling device is as follows:
When standby mode, sampling mechanism is in reset position, i.e., position as shown in Figure 2 resets optocoupler at this time and (resets letter
Number device 71) it is triggered by chopper blade (trigger 73) and is in triggering state, assigning instruction when host computer makes 21 turns of stepper motor
Dynamic, then stepper motor 21 drives the rotation of ball-screw 23 to be accurate to specimen needle 4 to drive sampling mechanism to move along guide rail 14
Up to sample position, optocoupler (termination signal device 72) is terminated at this time and is triggered by chopper blade (trigger 73) and is in triggering state,
Sampling mechanism stop motion, and specimen needle 4 gos deep into sample bottom at this time, it is ensured that all sample liquids are flowed by specimen needle 4
Detection analysis instrument;After the completion of to be sampled, sampler resets, and sampling mechanism returns to reset position and enters standby mode, under waiting
One actuation cycle.
The present embodiments relate to the material arrived, reagent and experimental facilities, are to meet inspection detection unless otherwise instructed
The commercial product in field.
The above is merely a preferred embodiment of the present invention, it is noted that for those skilled in the art
For, under the premise of not departing from core of the invention technology, improvements and modifications can also be made, these improvements and modifications are also answered
Belong to scope of patent protection of the invention.With any change in the comparable meaning and scope of claims of the present invention, all
It is considered as being included within the scope of the claims.
Claims (13)
1. sampler, which is characterized in that including sampling mechanism, be connected and fixed mechanism, driving mechanism, sampling mechanism is slidably connected
In being connected and fixed mechanism, driving mechanism can drive sampling mechanism to slide on being connected and fixed mechanism;It further include sampling positioning group
Part is used to sampling mechanism being positioned at desired location;Wherein sampling positioning component, which is set to, is connected and fixed in mechanism and/or detects
The other positions of analyzer.
2. sampler according to claim 1, which is characterized in that the sampling mechanism is fixed on described by link block
Driving mechanism, the sampling mechanism have at least one specimen needle.
3. sampler according to claim 1, which is characterized in that more arrangements of the specimen needle form specimen needle group.
4. sampler according to claim 2, which is characterized in that the sampling mechanism includes specimen needle support, described
Specimen needle is removably mounted to the specimen needle support, mounting plane of the specimen needle perpendicular to the specimen needle support;Institute
Stating sampling mechanism further includes pinboard, and the specimen needle support is fixedly mounted or is removably mounted to the pinboard, the company
It connects block and is fixed on the pinboard, the pinboard plane and the mounting plane of specimen needle support are parallel to each other.
5. sampler according to claim 1, which is characterized in that the sampling mechanism includes sliding block, corresponding described
Mechanism is connected and fixed equipped with guide rail.
6. sampler according to claim 1, which is characterized in that the mechanism that is connected and fixed includes symmetrically arranged two
A track base, each track base are provided with guide rail;The sampling positioning component is at least one group, and is set to the guide rail
The side of seat.
7. sampler according to claim 1, which is characterized in that the sampling positioning component includes mutually matched letter
Number device and trigger, the signalling means, which includes at least reset signal device be arranged along the sampling mechanism glide direction and terminates, to be believed
Number device;The set-up mode of the sampling positioning component is to be connected and fixed mechanism, the trigger described in the signalling means is set to
It is set to the sampling mechanism or the signalling means is set to the other positions of detection analysis instrument, the trigger is set to
The sampling mechanism.
8. sampler according to claim 1, which is characterized in that the driving mechanism includes stepper motor, ball wire
Thick stick, the ball-screw are fixedly connected with the sampling mechanism;Pass through yielding coupling between the stepper motor, ball-screw
Connection.
9. sampler according to claim 4, which is characterized in that the pinboard bottom is provided with ribs.
10. sampler according to claim 6, which is characterized in that the mechanism that is connected and fixed further includes fixed plate, institute
It states track base and is set to the fixed plate one side, the fixed plate another side is provided with for fixed with detection analysis instrument
Linking arm.
11. detection analysis instrument, which is characterized in that have the described in any item samplers of claim 1~10.
12. detection analysis instrument according to claim 11, which is characterized in that the sampler passes through solid in the connection
The linking arm for determining to be arranged in mechanism is installed on detection analysis instrument.
13. detection analysis instrument according to claim 11, which is characterized in that it is piarhemia parting detector, it is each for measuring
The cholesterol level of class lipoprotein.
Priority Applications (1)
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CN201810796719.9A CN109030847A (en) | 2018-07-19 | 2018-07-19 | Sampler and detection analysis instrument with the device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201810796719.9A CN109030847A (en) | 2018-07-19 | 2018-07-19 | Sampler and detection analysis instrument with the device |
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Publication Number | Publication Date |
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CN109030847A true CN109030847A (en) | 2018-12-18 |
Family
ID=64644315
Family Applications (1)
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CN201810796719.9A Pending CN109030847A (en) | 2018-07-19 | 2018-07-19 | Sampler and detection analysis instrument with the device |
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