CN109010608A - Antitumor oral liquid and preparation method thereof - Google Patents
Antitumor oral liquid and preparation method thereof Download PDFInfo
- Publication number
- CN109010608A CN109010608A CN201811014697.2A CN201811014697A CN109010608A CN 109010608 A CN109010608 A CN 109010608A CN 201811014697 A CN201811014697 A CN 201811014697A CN 109010608 A CN109010608 A CN 109010608A
- Authority
- CN
- China
- Prior art keywords
- preparation
- oral liquid
- decoction
- juice
- concentrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 31
- 230000000259 anti-tumor effect Effects 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 25
- 235000008504 concentrate Nutrition 0.000 claims abstract description 21
- 239000012141 concentrate Substances 0.000 claims abstract description 21
- 239000000706 filtrate Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 17
- 230000008569 process Effects 0.000 claims abstract description 15
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 14
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 14
- 235000019441 ethanol Nutrition 0.000 claims abstract description 13
- 241000411851 herbal medicine Species 0.000 claims abstract description 11
- 238000001556 precipitation Methods 0.000 claims abstract description 10
- 235000012907 honey Nutrition 0.000 claims abstract description 9
- 235000019198 oils Nutrition 0.000 claims abstract description 9
- 235000020374 simple syrup Nutrition 0.000 claims abstract description 9
- 240000007185 Albizia julibrissin Species 0.000 claims description 8
- 235000011468 Albizia julibrissin Nutrition 0.000 claims description 8
- 241000031023 Amana edulis Species 0.000 claims description 8
- 241000208340 Araliaceae Species 0.000 claims description 8
- 206010004542 Bezoar Diseases 0.000 claims description 8
- 241000717739 Boswellia sacra Species 0.000 claims description 8
- 241000269420 Bufonidae Species 0.000 claims description 8
- 244000157790 Buglossoides arvense Species 0.000 claims description 8
- 235000004256 Buglossoides arvense Nutrition 0.000 claims description 8
- 244000020518 Carthamus tinctorius Species 0.000 claims description 8
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 8
- 241000258920 Chilopoda Species 0.000 claims description 8
- 241000931705 Cicada Species 0.000 claims description 8
- 240000007311 Commiphora myrrha Species 0.000 claims description 8
- 235000006965 Commiphora myrrha Nutrition 0.000 claims description 8
- 244000247747 Coptis groenlandica Species 0.000 claims description 8
- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 8
- 239000004863 Frankincense Substances 0.000 claims description 8
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 8
- 241001646826 Isodon rubescens Species 0.000 claims description 8
- 240000007049 Juglans regia Species 0.000 claims description 8
- 235000009496 Juglans regia Nutrition 0.000 claims description 8
- 240000003146 Lobelia chinensis Species 0.000 claims description 8
- 235000007265 Myrrhis odorata Nutrition 0.000 claims description 8
- 241000180649 Panax notoginseng Species 0.000 claims description 8
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 8
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 8
- 241000237636 Pheretima Species 0.000 claims description 8
- 241000522620 Scorpio Species 0.000 claims description 8
- 241001212228 Sesbania drummondii Species 0.000 claims description 8
- 235000002594 Solanum nigrum Nutrition 0.000 claims description 8
- 240000002307 Solanum ptychanthum Species 0.000 claims description 8
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims description 8
- 240000006688 Telosma cordata Species 0.000 claims description 8
- 235000017352 Telosma cordata Nutrition 0.000 claims description 8
- 206010047700 Vomiting Diseases 0.000 claims description 8
- 244000029687 Wikstroemia indica Species 0.000 claims description 8
- 235000008434 ginseng Nutrition 0.000 claims description 8
- 239000009490 scorpio Substances 0.000 claims description 8
- 239000002435 venom Substances 0.000 claims description 8
- 231100000611 venom Toxicity 0.000 claims description 8
- 210000001048 venom Anatomy 0.000 claims description 8
- 230000008673 vomiting Effects 0.000 claims description 8
- 235000020234 walnut Nutrition 0.000 claims description 8
- 241000596154 Belamcanda Species 0.000 claims description 7
- 235000014571 nuts Nutrition 0.000 claims description 7
- 244000097577 Rhus javanica Species 0.000 claims description 5
- 235000010889 Rhus javanica Nutrition 0.000 claims description 5
- 235000007154 Salvia chinensis Nutrition 0.000 claims description 5
- 244000143590 Salvia chinensis Species 0.000 claims description 5
- 230000008719 thickening Effects 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 239000002893 slag Substances 0.000 claims description 3
- 240000001949 Taraxacum officinale Species 0.000 claims 2
- 244000107975 Strychnos nux-vomica Species 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 206010028980 Neoplasm Diseases 0.000 description 17
- 201000011510 cancer Diseases 0.000 description 13
- 241000245665 Taraxacum Species 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 235000003434 Sesamum indicum Nutrition 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- 206010020718 hyperplasia Diseases 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 239000004575 stone Substances 0.000 description 3
- 244000000231 Sesamum indicum Species 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 230000004596 appetite loss Effects 0.000 description 2
- 235000021266 loss of appetite Nutrition 0.000 description 2
- 208000019017 loss of appetite Diseases 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010053159 Organ failure Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 244000040738 Sesamum orientale Species 0.000 description 1
- 241000254223 Syntexis Species 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000032677 cell aging Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000021332 multicellular organism growth Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Insects & Arthropods (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
Abstract
The invention discloses a kind of antitumor oral liquid and preparation method thereof, which includes: 1) to crush Chinese herbal medicine, is then placed in water the multiple decoction of progress and handles to obtain juice；2) ethyl alcohol progress water extract-alcohol precipitation is added into juice and staticizes processing, then filters to take filtrate, then filtrate is concentrated to obtain concentrate；3) concentrate, ganoderma lucidum spore oil, honey, simple syrup are mixed to obtain antitumor oral liquid.The antitumor oral liquid is low in cost, Small side effects and curative effect are more excellent, while the preparation method has the advantages that process is simple and convenient for operation.
Description
Technical field
The present invention relates to anticancer drugs, and in particular, to a kind of antitumor oral liquid and preparation method thereof.
Background technique
Annual cancer also has 1,000,000 people therefore to lose life cancer in lethal 7,000,000 people in the whole world, China.Cancer is also evil
Property tumour, opposite has benign tumour.Tumour refers to body under the effect of various tumorigenesis factors, and the cell of local organization increases extremely
Raw and formation local lump.Benign tumour is easy to remove completely, does not shift generally, does not recur, and only squeezes organ, tissue
And blocking action.But malignant tumour can also destroy the structure and function of tissue, organ, cause necrotic hemorrhage concurrent infection, suffer from
Person may finally be dead due to organ failure.The basic unit of cancerous lesion is cancer cell, and human body cell aging is dead
After have neonatal cell and replace it, to maintain body function.Human body overwhelming majority cell can hyperplasia, but this hyperplasia is that have
Limit, and the hyperplasia of cancer cell be then it is endless, this consumes the nutriment of patient's body largely.Meanwhile cancer is thin
Born of the same parents can also release a variety of toxin, and human body is made to generate a series of symptoms.If it find that not in time with treatment, it also can be transferred to entirely
It is impaired etc. to finally result in human body syntexis, inability, anaemia, loss of appetite, fever and organ function for body growth and breeding everywhere.Human body
Almost each position can suffer from cancer infringement.
Although most anticancer drug or being expensive or being treatment effect currently, there are anticancer drug
Fruit is bad or is that side effect is excessive, so that the healing of cancer brings greatly difficulty.
Summary of the invention
The object of the present invention is to provide a kind of antitumor oral liquid and preparation method thereof, the antitumor oral liquid is low in cost, secondary
It is more excellent to act on small and curative effect, while the preparation method has the advantages that process is simple and is convenient for operation.
To achieve the goals above, the present invention provides a kind of preparation methods of antitumor oral liquid, comprising:
1) Chinese herbal medicine is crushed, is then placed in water the multiple decoction of progress and handles to obtain juice；
2) ethyl alcohol progress water extract-alcohol precipitation is added into juice and staticizes processing, is then filtered to take filtrate, is then carried out filtrate
Concentration is to obtain concentrate；
3) concentrate, ganoderma lucidum spore oil, honey, simple syrup are mixed to obtain antitumor oral liquid；
Wherein, take juice to stay slag after each decoction processing, then the dregs of a decoction be subjected to next decoction, finally merge all decoctions with
Obtain juice；Chinese herbal medicine is by Chinese violet, Radix Notoginseng, scorpio, centipede, the dried venom of toads, Asian puccoon, vomiting nut, cow-bezoar, silk tree, indigo naturalis, Rhizoma Atractylodis Macrocephalae, stone
See wear, granatum, coptis root, toad skin, olibanum, myrrh, edible tulip, dandelion, Radix Glycyrrhizae, naze, Rabdosia rubescens, black nightshade, blackberry lily, crow gallbladder
Son, cicada slough, pheretima, lobelia chinensis, safflower, Rhizoma Chuanxiong, walnut kernel, rhizoma arisaematis, Wikstroemia indica, Radix Rehmanniae, rhizoma dioscoreae nipponicae, rattlebush, ginseng, spirit
Sesame composition.
The present invention also provides a kind of antitumor oral liquid, which is prepared by upper preparation method.
In above-mentioned technical proposal, by the present invention in that with a variety of natural Chinese medicinal herbs so that be made antitumor oral liquid include with
Lower effect: lymphocyte immunity ability is adjusted；The physiological activity for inhibiting tumour cell, prevents the regeneration and transfer of cancer cell.Subtract
Light patient is because of toxic side effect, especially leukopenia caused by Radiotherapy chemotherapy；Patient is improved to the tolerance of Radiotherapy chemotherapy；Drop
Transfer, recurrence rate after low patients surgery, Radiotherapy chemotherapy；Tumor patient is improved to the tolerance of chemicotherapy, mitigates chemicotherapy and causes
Loss of appetite, vomiting, weight loss, oligoleukocythemia, anaemia, anti-infection ability reduce etc. serious adverse reactions and liver,
The damage of kidney, heart function.
Other features and advantages of the present invention will the following detailed description will be given in the detailed implementation section.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The present invention provides a kind of preparation methods of antitumor oral liquid, comprising:
1) Chinese herbal medicine is crushed, is then placed in water the multiple decoction of progress and handles to obtain juice；
2) ethyl alcohol progress water extract-alcohol precipitation is added into juice and staticizes processing, is then filtered to take filtrate, is then carried out filtrate
Concentration is to obtain concentrate；
3) concentrate, ganoderma lucidum spore oil, honey, simple syrup are mixed to obtain antitumor oral liquid；
Wherein, take juice to stay slag after each decoction processing, then the dregs of a decoction be subjected to next decoction, finally merge all decoctions with
Obtain juice；Chinese herbal medicine is by Chinese violet, Radix Notoginseng, scorpio, centipede, the dried venom of toads, Asian puccoon, vomiting nut, cow-bezoar, silk tree, indigo naturalis, Rhizoma Atractylodis Macrocephalae, stone
See wear, granatum, coptis root, toad skin, olibanum, myrrh, edible tulip, dandelion, Radix Glycyrrhizae, naze, Rabdosia rubescens, black nightshade, blackberry lily, crow gallbladder
Son, cicada slough, pheretima, lobelia chinensis, safflower, Rhizoma Chuanxiong, walnut kernel, rhizoma arisaematis, Wikstroemia indica, Radix Rehmanniae, rhizoma dioscoreae nipponicae, rattlebush, ginseng, spirit
Sesame composition.
In the present invention, the consumption proportion of each Chinese herbal medicine can select in a wide range, but in order to further increase
Its curative effect, it is preferable that Chinese violet, Radix Notoginseng, scorpio, centipede, the dried venom of toads, Asian puccoon, vomiting nut, cow-bezoar, silk tree, indigo naturalis, Rhizoma Atractylodis Macrocephalae, stone
See wear, granatum, coptis root, toad skin, olibanum, myrrh, edible tulip, dandelion, Radix Glycyrrhizae, naze, Rabdosia rubescens, black nightshade, blackberry lily, crow gallbladder
Son, cicada slough, pheretima, lobelia chinensis, safflower, Rhizoma Chuanxiong, walnut kernel, rhizoma arisaematis, Wikstroemia indica, Radix Rehmanniae, rhizoma dioscoreae nipponicae, rattlebush, ginseng, spirit
The weight ratio of sesame is 10-15,15-20,10-20,10-20,10-20,10-15,10-20,10-15,10-20,10-20,10-
15、20-30、10-20、10-20、10-20、20-30、10-15、20-30、5-10、5-10、10-15、20-30、10-15、10-
20、10-15、20-30、15-20、20-30、10-20、10-20、15-25、20-30、20-30、10-15、10-20、10-15、
30-50、40-60。
In the present invention, the dosage of water can select in a wide range in each decoction process, but in order to further
Improve its curative effect, it is preferable that in each decoction process, solid-liquid volume ratio remains 1:3-8.
In the present invention, decocting number of processing can select in a wide range, but control to further increase it
More effect, it is preferable that decocting number of processing is 3-5 times.
In the present invention, the condition of each decoction process can select in a wide range, but in order to further increase
Its curative effect, it is preferable that each decoction process meets the following conditions: decocting temperature is 90-100 DEG C, decocting time 5-6h.
In the present invention, the dosage that water extract-alcohol precipitation staticizes ethyl alcohol in processing can select in a wide range, but in order to
Further increase its curative effect, it is preferable that water extract-alcohol precipitation staticizes in processing, juice, ethyl alcohol weight ratio be 10:5-7.
In the present invention, the condition of concentration can select in a wide range, but cure effect to further increase it
Fruit, it is preferable that concentration meets the following conditions: thickening temperature is 90-100 DEG C, and the volume for being concentrated into concentrate accounts for filtrate
The 1/8-1/10 of volume.
In step 3) of the invention, the dosage of each material can select in a wide range, but in order to further mention
Its high curative effect, it is preferable that concentrate, ganoderma lucidum spore oil, honey, simple syrup volume ratio be 100:0.8-1.2:4-6:8-
12。
In the present invention, the form of smashed Chinese herbal medicine can select in a wide range, but in order to further mention
Its high curative effect, it is preferable that smashed Chinese herbal medicine is sheet, section shape or powdered.
The present invention also provides a kind of antitumor oral liquid, which is prepared by upper preparation method.
In the present invention, the application method of antitumor oral liquid can select in a wide range, but in order to further mention
Its high curative effect, it is preferable that the single dose of antitumor oral liquid is 30-50mL, and it is 2-3 times that single, which takes number,.
The present invention will be described in detail by way of examples below.
Embodiment 1
1) by Chinese violet, Radix Notoginseng, scorpio, centipede, the dried venom of toads, Asian puccoon, vomiting nut, cow-bezoar, silk tree, indigo naturalis, Rhizoma Atractylodis Macrocephalae, salvia chinensis,
Granatum, coptis root, toad skin, olibanum, myrrh, edible tulip, dandelion, Radix Glycyrrhizae, naze, Rabdosia rubescens, black nightshade, blackberry lily, Java brucea, cicada
Slough off, pheretima, lobelia chinensis, safflower, Rhizoma Chuanxiong, walnut kernel, rhizoma arisaematis, Wikstroemia indica, Radix Rehmanniae, rhizoma dioscoreae nipponicae, rattlebush, ginseng, ganoderma lucidum by
According to 10,15,10,10,10,10,10,10,10,10,10,20,10,10,10,20,10,20,5,5,10,20,10,10,10,
20,15,20,10,10,15,20,20,10,10,10,30,40 weight ratio crushes sheet, section shape or powdered, is then placed in
Carry out decocting processing that 3 times (in each decoction process, solid-liquid volume ratio remains 1:3 in water；It is decocted in each decoction process
Boiling temperature is 90 DEG C, decocting time 6h) obtain juice；
2) into the juice add ethyl alcohol carry out water extract-alcohol precipitation staticize processing 12h (juice, ethyl alcohol weight ratio be 10:
5) filtrate, is then filtered to take, then filtrate is concentrated to (thickening temperature is 90 DEG C, and the volume for being concentrated into concentrate accounts for
The 1/8 of the volume of filtrate) to obtain concentrate；
3) concentrate, ganoderma lucidum spore oil, honey, simple syrup are mixed according to the volume ratio of 100:0.8:4:8 to obtain
To antitumor oral liquid A1.
Embodiment 2
1) by Chinese violet, Radix Notoginseng, scorpio, centipede, the dried venom of toads, Asian puccoon, vomiting nut, cow-bezoar, silk tree, indigo naturalis, Rhizoma Atractylodis Macrocephalae, salvia chinensis,
Granatum, coptis root, toad skin, olibanum, myrrh, edible tulip, dandelion, Radix Glycyrrhizae, naze, Rabdosia rubescens, black nightshade, blackberry lily, Java brucea, cicada
Slough off, pheretima, lobelia chinensis, safflower, Rhizoma Chuanxiong, walnut kernel, rhizoma arisaematis, Wikstroemia indica, Radix Rehmanniae, rhizoma dioscoreae nipponicae, rattlebush, ginseng, ganoderma lucidum by
According to 13,18,15,15,15,13,15,13,15,15,13,25,15,15,15,25,13,25,8,8,13,25,13,15,13,
25,18,25,15,15,20,25,25,13,15,13,40,50 weight ratio crushes sheet, section shape or powdered, is then placed in
Carry out decocting processing that 4 times (in each decoction process, solid-liquid volume ratio remains 1:5 in water；It is decocted in each decoction process
Boiling temperature is 95 DEG C, decocting time 5.5h) obtain juice；
2) into the juice add ethyl alcohol carry out water extract-alcohol precipitation staticize processing 18h (juice, ethyl alcohol weight ratio be 10:
6) filtrate, is then filtered to take, then filtrate is concentrated to (thickening temperature is 95 DEG C, and the volume for being concentrated into concentrate accounts for
The 1/9 of the volume of filtrate) to obtain concentrate；
3) concentrate, ganoderma lucidum spore oil, honey, simple syrup are mixed according to the volume ratio of 100:1:5:10 to obtain
Antitumor oral liquid A2.
Embodiment 3
1) by Chinese violet, Radix Notoginseng, scorpio, centipede, the dried venom of toads, Asian puccoon, vomiting nut, cow-bezoar, silk tree, indigo naturalis, Rhizoma Atractylodis Macrocephalae, salvia chinensis,
Granatum, coptis root, toad skin, olibanum, myrrh, edible tulip, dandelion, Radix Glycyrrhizae, naze, Rabdosia rubescens, black nightshade, blackberry lily, Java brucea, cicada
Slough off, pheretima, lobelia chinensis, safflower, Rhizoma Chuanxiong, walnut kernel, rhizoma arisaematis, Wikstroemia indica, Radix Rehmanniae, rhizoma dioscoreae nipponicae, rattlebush, ginseng, ganoderma lucidum by
According to 15,20,20,20,20,15,20,15,20,20,15,30,20,20,20,30,15,30,10,10,15,30,15,20,15,
30,20,30,20,20,25,30,30,15,20,15,50,60 weight ratio crushes sheet, section shape or powdered, is then placed in
Carry out decocting processing that 5 times (in each decoction process, solid-liquid volume ratio remains 1:8 in water；It is decocted in each decoction process
Boiling temperature is 100 DEG C, decocting time 5h) obtain juice；
2) into the juice add ethyl alcohol carry out water extract-alcohol precipitation staticize processing for 24 hours (juice, ethyl alcohol weight ratio be 10:
7) filtrate, is then filtered to take, then filtrate is concentrated to (thickening temperature is 100 DEG C, and the volume for being concentrated into concentrate accounts for
The 1/10 of the volume of filtrate) to obtain concentrate；
3) concentrate, ganoderma lucidum spore oil, honey, simple syrup are mixed according to the volume ratio of 100:1.2:6:12 to obtain
To antitumor oral liquid A3.
Application examples 1
It chooses 100 and takes above-mentioned antitumor oral liquid by the initial stage patient of cancer cutting operation, take daily 3 times, it is single
It is secondary to take 40mL；Then cancer return rate in 5 years is monitored, has taken in the process the side reactions such as whether occur vomitting, it is specific to tie
Fruit is shown in Table 1.
Table 1
| Cancer return rate/% | Side reaction | |
| A1 | 21 | Nothing |
| A2 | 18 | Nothing |
| A3 | 22 | Nothing |
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this
A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (10)
1. a kind of preparation method of antitumor oral liquid characterized by comprising
1) Chinese herbal medicine is crushed, is then placed in water the multiple decoction of progress and handles to obtain juice；
2) ethyl alcohol progress water extract-alcohol precipitation is added into the juice and staticizes processing, is then filtered to take filtrate, is then carried out filtrate
Concentration is to obtain concentrate；
3) concentrate, ganoderma lucidum spore oil, honey, simple syrup are mixed to obtain antitumor oral liquid；
Wherein, it takes juice to stay slag after each decoction processing, then the dregs of a decoction is subjected to next decoction, merge all decoctions finally to obtain
The juice；The Chinese herbal medicine is by Chinese violet, Radix Notoginseng, scorpio, centipede, the dried venom of toads, Asian puccoon, vomiting nut, cow-bezoar, silk tree, indigo naturalis, white
Art, granatum, coptis root, toad skin, olibanum, myrrh, edible tulip, dandelion, Radix Glycyrrhizae, naze, Rabdosia rubescens, black nightshade, is penetrated salvia chinensis
Dry, Java brucea, cicada slough, pheretima, lobelia chinensis, safflower, Rhizoma Chuanxiong, walnut kernel, rhizoma arisaematis, Wikstroemia indica, Radix Rehmanniae, rhizoma dioscoreae nipponicae, rattlebush,
Ginseng, ganoderma lucidum composition.
2. preparation method according to claim 1, wherein the Chinese violet, Radix Notoginseng, scorpio, centipede, the dried venom of toads, Asian puccoon, Strychnos nux-vomica
Son, cow-bezoar, silk tree, indigo naturalis, Rhizoma Atractylodis Macrocephalae, salvia chinensis, granatum, coptis root, toad skin, olibanum, myrrh, edible tulip, dandelion, Radix Glycyrrhizae,
Naze, Rabdosia rubescens, black nightshade, blackberry lily, Java brucea, cicada slough, pheretima, lobelia chinensis, safflower, Rhizoma Chuanxiong, walnut kernel, rhizoma arisaematis, Wikstroemia indica,
Radix Rehmanniae, rhizoma dioscoreae nipponicae, rattlebush, ginseng, ganoderma lucidum weight ratio be 10-15,15-20,10-20,10-20,10-20,10-15,10-
20、10-15、10-20、10-20、10-15、20-30、10-20、10-20、10-20、20-30、10-15、20-30、5-10、5-
10、10-15、20-30、10-15、10-20、10-15、20-30、15-20、20-30、10-20、10-20、15-25、20-30、
20-30、10-15、10-20、10-15、30-50、40-60。
3. preparation method according to claim 1, wherein in each decoction process, solid-liquid volume ratio is remained
1:3-8.
4. preparation method according to claim 1, wherein decocting number of processing is 3-5 times.
5. preparation method according to claim 1, wherein each decoction process meets the following conditions: decoction temperature is 90-
100 DEG C, decocting time 5-6h.
6. preparation method according to claim 1, wherein the water extract-alcohol precipitation staticizes in processing, the juice, ethyl alcohol
Weight ratio is 10:5-7.
7. preparation method according to claim 1, wherein the concentration meets the following conditions: thickening temperature 90-100
DEG C, and the volume for being concentrated into concentrate accounts for the 1/8-1/10 of the volume of filtrate.
8. preparation method according to claim 1, wherein the concentrate, ganoderma lucidum spore oil, honey, simple syrup body
Product is than being 100:0.8-1.2:4-6:8-12.
9. preparation method according to claim 1, wherein smashed Chinese herbal medicine is sheet, section shape or powdered.
10. a kind of antitumor oral liquid, which is characterized in that the antitumor oral liquid passes through described in any one of claim 1-9
Preparation method be prepared；
Preferably, the single dose of the antitumor oral liquid is 30-50mL, and it is 2-3 times that single, which takes number,.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811014697.2A CN109010608A (en) | 2018-08-31 | 2018-08-31 | Antitumor oral liquid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811014697.2A CN109010608A (en) | 2018-08-31 | 2018-08-31 | Antitumor oral liquid and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109010608A true CN109010608A (en) | 2018-12-18 |
Family
ID=64622743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811014697.2A Pending CN109010608A (en) | 2018-08-31 | 2018-08-31 | Antitumor oral liquid and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109010608A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456907A (en) * | 2014-08-22 | 2016-04-06 | 天津浩本圣医药科技有限公司 | Anticancer jelly |
| CN106729407A (en) * | 2016-12-27 | 2017-05-31 | 四川西奈生物科技有限公司 | The Chinese medicine composition for the treatment of cancer |
-
2018
- 2018-08-31 CN CN201811014697.2A patent/CN109010608A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456907A (en) * | 2014-08-22 | 2016-04-06 | 天津浩本圣医药科技有限公司 | Anticancer jelly |
| CN106729407A (en) * | 2016-12-27 | 2017-05-31 | 四川西奈生物科技有限公司 | The Chinese medicine composition for the treatment of cancer |
Non-Patent Citations (1)
| Title |
|---|
| 师建国，等: "《现代肿瘤康复》", 31 July 2004 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102327588B (en) | Method for preparing traditional Chinese medicine (TCM) lotion for treating anorexia bedsore | |
| CN102772678B (en) | Preparation method of traditional Chinese medicine lotion for treating heat-toxin colpitis mycotica | |
| CN102631572B (en) | Method for preparing traditional Chinese medicine (TCM) lotion for treating hemorrhagic pustule on sole | |
| CN102631532B (en) | Method for preparing traditional Chinese medicine (TCM) for treating heat toxicity type acute lymphangitis | |
| CN102641438B (en) | Preparation method for traditional Chinese medicine for treating heat-toxin ecthyma | |
| CN101829278A (en) | Quick antiphlogistic and analgesic Chinese herbal preparation | |
| CN104758524A (en) | Traditional Chinese medicinal composition for treating hepatic hemangioma with symptoms of phlegm dampness and retention | |
| CN109010608A (en) | Antitumor oral liquid and preparation method thereof | |
| CN108057107A (en) | A kind of pharmaceutical composition of rapid drop and elimination malignant tumour and preparation method thereof | |
| CN102631571A (en) | Method for preparing traditional Chinese medicine lotion for treating drinking-type furuncle on sole | |
| CN103385943B (en) | Chinese medicine of a kind of Therapeutic cancer and preparation method thereof | |
| CN102366579B (en) | Preparation method of traditional Chinese medicine lotion for treating clothes lack-type bedsore | |
| CN102813853B (en) | Preparation method of Chinese medicinal lotion treating heat-toxin type closed fractures | |
| CN104815059A (en) | Traditional Chinese medicine for treating chronic hepatitis | |
| CN104274706A (en) | Traditional Chinese medicine mixture for treating radioactive stomatitis | |
| CN104623414A (en) | Traditional Chinese medicine composition for treating nutritional obesity | |
| CN105878509A (en) | Preparation method of traditional Chinese medicine liquid for treating pruritic scrotal eczema | |
| CN102743616A (en) | Preparation method of Chinese medicine irrigation solution for treating damp-heat type chronic cervicitis | |
| CN102824561B (en) | Preparation method of traditional Chinese medicine lotion for treating alcoholic closed fracture | |
| CN102793853B (en) | Preparation method of traditional Chinese medicine lotion for treating constipation type closed fracture | |
| CN102178883B (en) | Preparation method of traditional Chinese medicine for treating hunger type frostbite | |
| CN102824537B (en) | Method of preparing traditional Chinese medicine lotion for treating stomach anorexia type closed fracture | |
| CN105687938A (en) | Traditional Chinese medicine preparation for anal fissure and preparation method thereof | |
| CN104888105A (en) | Traditional Chinese medicine for treating primary liver cancer | |
| CN104645247A (en) | Traditional Chinese medicine preparation for treating hepatolenticular degeneration and preparation method of traditional Chinese medicine preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181218 |