CN109010478A

CN109010478A - A kind of drug and preparation method thereof for treating hemorrhoid

Info

Publication number: CN109010478A
Application number: CN201810995933.7A
Authority: CN
Inventors: 曾川贵; 左敏
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-08-29
Filing date: 2018-08-29
Publication date: 2018-12-18

Abstract

The invention belongs to medicament preparations, more particularly to the drug and preparation method thereof for the treatment of hemorrhoid, which is made of 5~30 parts of Zanthoxylum essential oil, 10~50 parts of gardenia, 5~45 parts of sesame oil, 10~50 parts of borneol, 10~25 parts of mother of vinegar grass, 5~15 parts of catechu and 10~20 parts of Radix Notoginseng.The preparation method comprises the following steps: S1. is crushed: borneol, mother of vinegar grass, gardenia, catechu and Radix Notoginseng being respectively dried, then crushed respectively, obtains borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder and Radix Notoginseng powder, for use；S2. impregnate: borneol powder, mother of vinegar grass meal, catechu powder, Radix Notoginseng powder, cape jasmine pollen, Zanthoxylum essential oil and sesame oil are uniformly mixed, be soaked for a period of time to get.The present invention treats the drug of hemorrhoid, and various bulk pharmaceutical chemicals all medicines shares have convergence, hemostasis, antibacterial, activating microcirculation and removing stasis medicinal, anti-inflammatory, swelling and pain relieving, clearing heat and detoxicating, cooling blood and relieving pain, the effect of broken stasis of blood detumescence, to achieve the effect that treat hemorrhoid.

Description

A kind of drug and preparation method thereof for treating hemorrhoid

Technical field

The present invention relates to pharmaceutical products, it particularly relates to a kind of drug and preparation method thereof for treating hemorrhoid.

Background technique

Hemorrhoid are a kind of common diseases positioned at anus area, and any age can all fall ill, but with advancing age, hair Sick rate gradually increases.In China, hemorrhoid are common anorectal diseases, and there are mainly two types of sayings for pathogenic factor: being vein first Varicose theory, it is believed that hemorrhoid are that veniplex extravasated blood, expansion and the buckling under distal rectal mucous membrane and under anal canal skin are formed by Venous mass；However well accepted theory is anal cushions down theory at present, it is believed that hemorrhoid are originally that anal canal position is normally dissected Structure, i.e. blood vessel pad are dentate line and the cyclic annular cavernous transformation taeniae telarum of the above 1.5cm.There are many risk factor of hemorrhoid, wherein just It is main inducing that secret, long-term alcohol, a large amount of irritable foods of feed and sitting are stood long, by the difference of happening part be divided into internal piles, External piles, mixed hemorrhoid.The main clinical manifestation of symptom has: hematochezia, and property is mainly painless, intermittent, blood after an action of the bowels, just when drip Band blood, constipation are drunk or are aggravated after feeding irritable food on blood or toilet paper；The only falling inflation sense of pure internal piles without pain, can go out Blood is developed to prolapsus, pain just occurs when merging thrombosis, incarceration, infection；Pain is uncomfortable, itch, wherein itch often due to Toughness secretion flows out when hemorrhoid are deviate from；External piles occurs can have swelling, pain when thrombus and inflammation usually without characteristic symptom.Mesh Preceding doctor trained in Western medicine can only be taken to have an operation and be treated, and have some patientss that can also recur after operation, can not fully and completely cure, market It is upper treatment hemorrhoid Chinese medicine also can only reduction of patient slight illness, treatment cycle is long, and is difficult to thoroughly eradicate hemorrhoid.

Summary of the invention

In view of this, the object of the present invention is to provide a kind of drug and preparation method thereof for treating hemorrhoid, it is existing to solve The medication effect for treating hemorrhoid is not good enough and.

The present invention solves above-mentioned technical problem by the following technical programs:

A kind of drug for treating hemorrhoid, in parts by weight, by 5~30 parts of Zanthoxylum essential oil, 5~45 parts of sesame oil, 10~50 parts of borneol, 10~25 parts of mother of vinegar grass, 10~50 parts of gardenia, 5~15 parts of catechu and 10~20 parts of Radix Notoginseng are made.

Further, the drug of the treatment hemorrhoid is by 8~24 parts of Zanthoxylum essential oil, 10~30 parts of sesame oil, borneol 15~45 Part, 12~20 parts of mother of vinegar grass, 15~45 parts of gardenia, 7~13 parts of catechu and 12~18 parts of Radix Notoginseng are made.

Further, the drug of the treatment hemorrhoid is by 16 parts of Zanthoxylum essential oil, 20 parts of sesame oil, 25 parts of borneol, mother of vinegar grass 17 parts, 30 parts of gardenia, 10 parts of catechu and 15 parts of Radix Notoginseng are made.

The borneol, mother of vinegar grass, gardenia, catechu and the parts by weight of Radix Notoginseng are the weight of the material dry weight.

It is described treatment hemorrhoid drug the preparation method comprises the following steps:

S1. it crushes: borneol, mother of vinegar grass, gardenia, catechu and Radix Notoginseng being respectively dried, then crushed respectively, acquisition borneol powder, Mother of vinegar grass meal, cape jasmine pollen, catechu powder and Radix Notoginseng powder, for use；

S2. it impregnates: borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder, Radix Notoginseng powder, Zanthoxylum essential oil and sesame oil is uniformly mixed, Be soaked for a period of time to get.

In the step S1, the temperature that borneol, mother of vinegar grass, gardenia, catechu and Radix Notoginseng are respectively adopted 80~100 DEG C is dried Doing to moisture content is 4~6%, and being then crushed to partial size respectively is 60~100 μm of fine powder, obtain borneol powder, mother of vinegar grass meal, Cape jasmine pollen, catechu powder and Radix Notoginseng powder.

In the step S2, by borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder, Radix Notoginseng powder, Zanthoxylum essential oil and sesame oil Mix in proportion, under room temperature impregnate 1~20d to get.

The Zanthoxylum essential oil is one is being in fragrant, product of the taste compound in edible vegetable oil from extracting in Chinese prickly ash, mainly Ingredient is carboxylic acid and carboxylate, and content accounts for the 66.45% of total content, and wherein amide substance content is 3.84%.Chinese prickly ash acrid flavour, property Heat, returns spleen, stomach meridian；There is the effect of fragrant stomach invigorating, warming spleen and stomach for dispelling cold, damp dispelling and pain relieving, desinsection removing toxic substances, antipruritic solution raw meat；Primary treatment is vomitted It spits, wind-cold-dampness arthralgia, the diseases such as dentalgia.

The sesame oil is extract from sesame, has special fragrance, therefore referred to as sesame oil.Rich in dimension life in sesame oil Plain E and linolenic acid, wherein vitamin E has antioxidation, can maintain the integrality and normal function of cell membrane, has and promotees Into cell division, softening blood vessel and the effect for keeping blood vessel elasticity, thus it is beneficial to protection cardiovascular and cerebrovascular.And the Asia in sesame oil The unsaturated fatty acids such as oleic acid, palmitinic acid are easy to be absorbed by the body, and help to eliminate the deposit on arterial wall, equally have The effect of protecting blood vessel.

The borneol is also known as borneol, kapur, brain, borneol, piece brain, borneol brain, plum blossom brain, natural borneol, old Borneolum And Borneolum.Borneol is the crystallization obtained from the resin and volatile oil of kapur, is almost pure d-Bomeol.Kapur Containing there are many ter penoids in resin and volatile oil.In addition to borneol, still containing sequiterpenes such as Humuleno, beta-elemene, carypohyllenes, together The triterpenoids such as pier tartaric acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, erythrodiol.Borneol tool There is preferable antibacterial and anti-inflammatory effect.

The medicinal part of the Radix Notoginseng is the dry root of plant, sweet in flavor, slight bitter, temperature.Cure mainly dissipating stasis and stanching bleeding, detumescence ding-tong, For spitting blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, chest and abdomen shouting pain, tumbling and swelling.

The mother of vinegar grass is oxalic nickname, all herbal medicine, the antipyretic diuresis of energy, eliminating stagnated blood to disperse swelling.

The gardenia also known as cape jasmine, Yellow Fructus Gardeniae, Gentianales Rubiaceae.Cape jasmine contains gardenoside, geniposide, Paederia scandens Secondary glucoside methyl esters and a small amount of shanzhiside have reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body, jaundice, blood strangury pain puckery, the red and swollen pain of mesh, fire toxin sore, blood pressure lowering And other effects.The present invention is with the fruit medicine of gardenia.

The catechu is the plant of pulse family Acacia, and the minimum inhibitory concentration (MIC) of catechu is to staphylococcus aureus For 2.8lmg/ml, staphylococcus albus 5.63mg/ml, beta hemolytic streptococcus 5.63mg/ml, candida albicans For 5.63mg/ml, also once reported catechu to Pseudomonas aeruginosa, corynebacterium diphtheriae, proteus.Shigella dysenteriae, typhoid bacillus etc. have suppression Production is used.Its contained d- cachou extract and epicatechin have a significant hepatoprotective effect, it is nonantigenic in the presence of d- cachou extract do not influence it is white Cell migration, but in vitro test inhibits the migration of the normal human leukocytes to protein derivatives (PPD) antigen sensitive of purifying, and To once infection hepatitis B and it is stronger to the inhibiting effect of leukoplania to the sensitive patient of hepatitis B surface antigen, shows that it can put Immune response that maxicell mediates and promote the removing of hepatitis B antigen.

The beneficial effects of the present invention are: the present invention treats the drug of hemorrhoid, and various bulk pharmaceutical chemicals all medicines shares have and receive It holds back, stop blooding, is antibacterial, activating microcirculation and removing stasis medicinal, anti-inflammatory, swelling and pain relieving, clearing heat and detoxicating, cooling blood and relieving pain, the effect of broken stasis of blood detumescence, to reach The effect for treating hemorrhoid.The drug that the present invention treats hemorrhoid can thoroughly eradicate hemorrhoid, have high excellent of short treating period, cure rate Point, 6 days courses for the treatment of, 1~3 course for the treatment of can cure, and cure rate is up to 96.2% or more, effective percentage up to 100%.

Specific embodiment

In order to facilitate the understanding of those skilled in the art, below in conjunction with embodiment, the present invention will be further described. Embodiment is only to the invention for example, not being limitation of the invention, the step of not illustrating in embodiment It is prior art, is not described in detail herein.

Embodiment 1

Raw material:

Zanthoxylum essential oil 5kg, sesame oil 5kg, borneol 10kg, gardenia 10kg, mother of vinegar grass 10kg, catechu 5kg and Radix Notoginseng 10kg.

Preparation method:

S1. crush: the temperature that borneol, mother of vinegar grass, gardenia, catechu and Radix Notoginseng are respectively adopted 80 DEG C, which is dried to moisture content, is 4%, it is then crushed to the fine powder that partial size is 60 μm respectively, obtains borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder and Radix Notoginseng Powder, for use；

S2. it impregnates: borneol powder, mother of vinegar grass meal, catechu powder, cape jasmine pollen, Radix Notoginseng powder, Zanthoxylum essential oil and sesame oil is mixed in proportion Uniformly, under room temperature impregnate 1d to get.

Embodiment 2

Raw material:

Zanthoxylum essential oil 30kg, sesame oil 45kg, borneol 50kg, gardenia 50kg, mother of vinegar grass 25kg, catechu 15kg and Radix Notoginseng 20kg.

Preparation method:

S1. it crushes: the temperature that borneol, mother of vinegar grass, gardenia, catechu and Radix Notoginseng are respectively adopted 100 DEG C is dried to moisture content It is 6%, is then crushed to the fine powder that partial size is 100 μm respectively, obtains borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder and three Seven powder, for use；

S2. it impregnates: borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder, Radix Notoginseng powder, Zanthoxylum essential oil and sesame oil is mixed in proportion Uniformly, under room temperature impregnate 20d to get.

Embodiment 3

Raw material:

Zanthoxylum essential oil 8kg, sesame oil 10kg, borneol 15kg, gardenia 15kg, mother of vinegar grass 12kg, catechu 7kg and Radix Notoginseng 12kg.

Preparation method:

S1. crush: the temperature that borneol, mother of vinegar grass, gardenia, catechu and Radix Notoginseng are respectively adopted 85 DEG C, which is dried to moisture content, is 4%, it is then crushed to the fine powder that partial size is 70 μm respectively, obtains borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder and Radix Notoginseng Powder, for use；

S2. it impregnates: borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder, Radix Notoginseng powder, Zanthoxylum essential oil and sesame oil is mixed in proportion Uniformly, under room temperature impregnate 3d to get.

Embodiment 4

Raw material:

Zanthoxylum essential oil 24kg, sesame oil 30kg, borneol 45kg, gardenia 45kg, mother of vinegar grass 20kg, catechu 13kg and Radix Notoginseng 18kg.

Preparation method:

S1. crush: the temperature that borneol, mother of vinegar grass, gardenia, catechu and Radix Notoginseng are respectively adopted 95 DEG C, which is dried to moisture content, is 6%, it is then crushed to the fine powder that partial size is 90 μm respectively, obtains borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder and Radix Notoginseng Powder, for use；

S2. it impregnates: borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder, Radix Notoginseng powder, Zanthoxylum essential oil and sesame oil is mixed in proportion Uniformly, under room temperature impregnate 18d to get.

Embodiment 5

Raw material:

Zanthoxylum essential oil 16kg, sesame oil 20kg, gardenia 30kg, borneol 25kg, mother of vinegar grass 17kg, catechu 10kg and Radix Notoginseng 15kg.

Preparation method:

S1. crush: the temperature that borneol, mother of vinegar grass, gardenia, catechu and Radix Notoginseng are respectively adopted 90 DEG C, which is dried to moisture content, is 5%, it is then crushed to the fine powder that partial size is 80 μm respectively, obtains borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder and Radix Notoginseng Powder, for use；

S2. it impregnates: borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder, Radix Notoginseng powder, Zanthoxylum essential oil and sesame oil is mixed in proportion Uniformly, under room temperature impregnate 10d to get.

Toxicity test:

Drug prepared by above-described embodiment one to embodiment five carries out malicious test, and drug prepared by embodiment 1 to 5 is applied to The wound of mouse, test result: not significant pathological change and death.

Hemorrhoid patients points for attention:

1, it should suitably be massaged using when this liquid, can promote to absorb.

2, fasting drinks and the irritable foods such as pungent, fried.

3, veterinary antibiotics are eaten more, form the habit of daily short time defecation.

4, regular living habit is formed, avoids staying up late.

5, daily sooner or later and after defecation with warm water hip bath, the hip bath time is unsuitable too long, and about ten to 15 minutes.

6, it avoids being always maintained at same posture, to remove extravasated blood, a little slight movements should be done once in a while, the people of sedentary working is every It preferably walks about three four minutes every a hour.

7, the drug of present invention treatment hemorrhoid is external application, is avoided oral.

Application method: 6 days are 1 course for the treatment of, cleans affected part with warm saline using preceding, and after being dried affected part with paper, use Drug prepared by the present invention is applied to affected part by cotton swab, is smeared 3~5 times daily.

Curative effect of the present invention is rapid, and 1 course for the treatment of of hemorrhoid patient with slight symptoms can cure, and 2~3 courses for the treatment of of patient with severe symptoms can be controlled More, in treatment case 239: curing and do not recur 230, cure but recurrence has 3,6 are felt that symptom mitigates, control More rate 96.2%, effective percentage up to 100%.

Typical case:

1, week certain, male, 69 years old, Guizhou Province people from Kweiyang suffered from mixed hemorrhoid and continues more than 20 years, attempted a variety of drugs and do not cure, Take a large amount of blood when bowel movement out of, it is in great pain.Drug prepared by the present invention is introduced and bought through friend when certain 58 years old week, uses this After one course for the treatment of of drug for inventing preparation, the state of an illness is clearly better, and after continuing to use two courses for the treatment of, hemorrhoid symptom is completely disappeared, until It does not recur within 11 years until the present.

2, Huang, female, 41 years old, Guizhou Province people from Kweiyang suffered from hemorrhoid and continues 12 years, and anus director has 6 internal piles, attempted excessive Kind of drug is not cured, and when bowel movement takes a large amount of blood out of, using after one course for the treatment of of drug prepared by the present invention at 36 years old, the state of an illness It is clearly better, after continuing to use a course for the treatment of, hemorrhoid symptom is completely disappeared, and is not recurred within 5 years up to now.

3, Wu, female, 31 years old, Guizhou Province people from Kweiyang suffered from hemorrhoid 2 years, and the thing for being able to eat fire during this period will defecate band Blood, and the pain that can all itch daily, have wiped many medicines without effect, two years ago is introduced and bought through friend and used prepared by the present invention After one course for the treatment of of drug, hemorrhoid symptom is completely disappeared, and does not recur up to now.

Claims

1. a kind of drug for treating hemorrhoid, it is characterised in that: in parts by weight, by 5~30 parts of Zanthoxylum essential oil, 5~45 parts of sesame oil, 10~50 parts of borneol, 10~50 parts of gardenia, 10~25 parts of mother of vinegar grass, 5~15 parts of catechu and 10~20 parts of Radix Notoginseng are made.

2. the drug for the treatment of hemorrhoid as described in claim 1, it is characterised in that: the drug of the treatment hemorrhoid is by Zanthoxylum essential oil 8 ~24 parts, 10~30 parts of sesame oil, 15~45 parts of gardenia, 15~45 parts of borneol, 12~20 parts of mother of vinegar grass, 7~13 parts of catechu It is made with 12~18 parts of Radix Notoginseng.

3. the drug for the treatment of hemorrhoid as described in claim 1, it is characterised in that: the drug of the treatment hemorrhoid is by Zanthoxylum essential oil 16 Part, 20 parts of sesame oil, 30 parts of gardenia, 25 parts of borneol, 17 parts of mother of vinegar grass, 10 parts of catechu and 15 parts of Radix Notoginseng are made.

4. the preparation method of the drug of the treatment hemorrhoid as described in claims 1 to 3 any one, it is characterised in that including following Step:

S2. it impregnates: borneol powder, mother of vinegar grass meal, catechu powder, Radix Notoginseng powder, cape jasmine pollen, Zanthoxylum essential oil and sesame oil is uniformly mixed, Be soaked for a period of time to get.

5. the preparation method of the drug for the treatment of hemorrhoid as claimed in claim 4, it is characterised in that: in the step S1, by ice It is 4%~6% that the temperature that piece, mother of vinegar grass, gardenia, catechu and Radix Notoginseng are respectively adopted 80 DEG C~100 DEG C, which is dried to moisture content, so It is crushed to the fine powder that partial size is 60~100 μm respectively afterwards, obtains borneol powder, mother of vinegar grass meal, cape jasmine pollen, catechu powder and Radix Notoginseng Powder.

6. the preparation method of the drug for the treatment of hemorrhoid as claimed in claim 4, it is characterised in that: in the step S2, by ice Piece powder, cape jasmine pollen, mother of vinegar grass meal, catechu powder, Radix Notoginseng powder, Zanthoxylum essential oil and sesame oil mix in proportion, and impregnate 1 under room temperature ~20d to get.