CN109010381A - Compound jinei jin tablet and preparation method thereof - Google Patents
Compound jinei jin tablet and preparation method thereof Download PDFInfo
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- CN109010381A CN109010381A CN201811181542.8A CN201811181542A CN109010381A CN 109010381 A CN109010381 A CN 109010381A CN 201811181542 A CN201811181542 A CN 201811181542A CN 109010381 A CN109010381 A CN 109010381A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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Abstract
The invention belongs to contain the pharmaceutical product technical field from birds material, and in particular to a kind of compound jinei jin tablet.The compound jinei jin tablet, including following components: endothelium corneum gigeriae galli, Medicated Leaven, sucrose, adhesive, magnesium stearate and coating material.The content of microorganisms of this method compound jinei jin tablet is low.
Description
Technical field
The invention belongs to contain the pharmaceutical product technical field from birds material, and in particular in a kind of compound chicken
Gold plaque and preparation method thereof.
Background technique
Endothelium corneum gigeriae galli also known as chicken yellow skin, chicken feed skin, chicken crop, chicken cavity skin, chicken needle skin, chicken intestines shell, chicken gastrodermis etc. derive from ridge
The drying inner wall of sandbag of the rope animal door rigid Phasianidae animal chicken of bird, the i.e. interior stomach film of chicken.Endothelium corneum gigeriae galli sugariness is puckery, flat, nontoxic, enters
Spleen, stomach, small intestine, bladder four pass through, and are good at disperse accumulation food, strengthening the spleen and stomach, puckery glutinous only lose, change the hard long-pending calculus that disappears.Endothelium corneum gigeriae galli is mainly by albumen
Matter composition, main component is gastric hormone, keratin like protein, pepsin, and contains vitamin, glutamic acid and asparatate etc.
17 kinds of amino acid, main component determines that endothelium corneum gigeriae galli has and increases gastric secretion, gastro-intestinal digestion performance, accelerates the emptying of stomach
Rate and other effects (" the modern study characteristic analysis of endothelium corneum gigeriae galli ", Zheng Yan etc., Chinese and Western journal, the 12nd phase of volume 30 in 2015, the
1796-1797 pages, publication date on December 31st, 2015).
Currently, the endothelium corneum gigeriae galli preparation of domestic listing is mainly compound jinei jin tablet.However, in the market in existing compound chicken
The content of microorganisms of gold plaque is high.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of compound jinei jin tablet, the microorganism of the compound jinei jin tablet
Content is low.
Unless otherwise indicated, proportion of the present invention is mass ratio.
To achieve the above object, the technical solution of the present invention is as follows:
Compound jinei jin tablet, including following components: endothelium corneum gigeriae galli, Medicated Leaven, sucrose, adhesive, magnesium stearate and coating material
Material.
Inventor has found in the course of the research, including endothelium corneum gigeriae galli, Medicated Leaven, sucrose, adhesive, magnesium stearate and coating material
The content of microorganisms of the compound jinei jin tablet of material is low.
Further, described adhesive is prepared by cornstarch, gelatin and purified water.
Further, described adhesive the preparation method comprises the following steps: purified water is heated to boiling, gelatin is added, is added after dissolving
The slurrying cornstarch of wetting, stirring are boiled 2 minutes, and heating is stopped, cooling.
Further, it is 0.8-1.3:95-100 that the dosage of the gelatin, which is with the mass ratio of purified water,.
Further, the mass ratio of purified water and cornstarch is 18-21:0.8- in the slurrying cornstarch soaked
1.1。
Further, the dosage of the slurrying cornstarch soaked be in slurrying cornstarch the cornstarch that contains with
The mass ratio 8-12:0.9-1.2 of gelatin.
Further, the coating material is made of sucrose, talcum powder, insect wax, lemon yellow and gelatin.
Further, the coating material is by sucrose, talcum powder, insect wax, lemon yellow and gelatin according to 210-270:220-
260:1-1.5:0.1-0.2:2-2.5 mass ratio composition.
Further, in terms of mass parts, proportion relation is 100-105 parts of endothelium corneum gigeriae galli, 195-200 parts of Medicated Leaven, sucrose 150-
200 parts, 40-45 parts of adhesive (mass fraction of cornstarch and gelatin is 10:1 in 10% starch slurry gelatin solution), tristearin
Sour magnesium 2-5 parts and coating material 500-505 parts.
The present invention also aims to protect the preparation method of the compound jinei jin tablet, comprising the following steps: endothelium corneum gigeriae galli,
Medicated Leaven and sucrose pulverize and sieve and mix, and adhesive granulation, dry, whole grain are then added, then stearic acid is added into particle
Magnesium is uniformly mixed, tabletting, coating, polishing, and cool.
Further, temperature≤80 DEG C of the drying, time are 60-80 minutes.
The beneficial effects of the present invention are:
Compound jinei jin tablet content of microorganisms made from method of the invention is low.
Compound jinei jin tablet uniformity of weight made from method of the invention is good.
Specific embodiment
Illustrated embodiment is to preferably be illustrated to the contents of the present invention, but is not that the contents of the present invention only limit
In illustrated embodiment.So those skilled in the art carry out nonessential change to embodiment according to foregoing invention content
Into and adjustment, still fall within protection scope of the present invention.
Embodiment 1
Compound jinei jin tablet is prepared in terms of recipe quantity 2,400,000 using following raw material and process:
A. the preparation of adhesive: purified water 31.6kg being added in jacketed pan and is heated to boiling, and 0.4kg gelatin is added, dissolves
The 4.0kg cornstarch for having used 8kg purified water to soak is added afterwards, stirring is boiled 2 minutes, and adhesive is made, and stops heating, to cold
But it is poured into clean rustless steel container afterwards.
B. mix: installation mesh number be 100 mesh sieve and collection flour bag, after opening sky machine normal operation, by 102kg endothelium corneum gigeriae galli,
198kg Medicated Leaven and 180kg sucrose are added to be switched in hopper and crush, and charging should be uniformly appropriate, after having crushed, by endothelium corneum gigeriae galli powder,
Mixing 10 minutes in mixing machine are packed into after Medicated Leaven powder and cane sugar powder mixing, the adhesive made is uniformly added into, continuess to mix 10
Minute.
C. pelletize, is dry: starting granulator (16 mesh nylon mesh of installation) starts to pelletize, and checks whether boiling drier cleans
Afterwards, filter bag is installed, opens after sky machine works well, blank wet granular negative pressure is sucked in boiling drier, temperature setting≤80
DEG C, start drying, observes particle boiling situation, air blast situation at any time, prevent the particle-bonded ceramic the bottom of a pan, cause particle coking or paste
Change, drying time is 70 minutes.
D. whole grain, mixing, tabletting: carrying out whole grain with the sieve of 16 mesh for the particle after drying, by 3.0kg magnesium stearate with
It is mixed in particle sucking double-cone mixer after whole grain, mixes 40 minutes, select suitable punch die, be correctly installed on tablet press machine,
Open sky machine trial operation it is errorless after, particle is set in loading hopper, according to technology person formulate weight differential range adjust slice weight, open
The a small amount of tablet of vehicle pressure testing, by the tabletting that can formally drive after regulation inspection appearance, weight differential qualification.Every 30 in tableting processes
Minute take 20 to survey average slice weights are primary, and every 2 hours primary by live QA measurement weight differential, weight differential control ±
Within 6.0%.
E. sugar coating:
The preparation of E1 simple syrup: taking purified water, is added in interlayer enamel pan after being heated to boiling, and the sugarcane of coating prescription is added
Sugar is stirred to dissolve, and fishes for foam suspension object, is boiled 5 minutes, and heating is stopped, and becomes 65% simple syrup, crosses 80 meshes.
It is poured into clean rustless steel container after syrup is cooling.
E2 glycocoll slurry is prepared: being taken 2.4kg purified water, is added in clean stainless steel barrel, 2.4kg gelatin is added, stirring makes molten
Swollen, heating makes to dissolve, and is stirred until homogeneous 28.8kg simple syrup is added in the gelatin solution after sieving, crosses 80 meshes, as glycocoll
It starches (separation layer liquid), prepared glycocoll slurry is poured into clean rustless steel container.
The preparation of E3 sugar colour slurry: after 0.16kg lemon yellow is uniformly dispersed with 0.48kg purified water, 20.8kg monosaccharide is added
Slurry makes it dissolve, and is configured to sugar colour slurry, spare.
E4 packet separation layer: the tablet obtained after pressing tablet is one pot according to 60 ± 5kg, is poured into coating pan, and coating is opened
Pot, starts packet separation layer, and first glycocoll slurry stainless steel spoon is added in coating pan, after coating tablet in pot sufficiently soaks, is sprinkled into
Talcum powder opens dust exhaust apparatus, turns to coating tablet average rate in coating pan after coating tablet uniformly wraps coating material, opens
Heating device carries out heated-air drying to coating tablet in pot, after coating tablet in pot is sufficiently dry, repeats aforesaid operations 4-6 times, with
Tablet package is foundation without black surround edge.
E5 packet sub-coat: starting coating pan starts packet sub-coat, and simple syrup stainless steel spoon is added in coating pan, is made
Coating tablet average rate in coating pan turns to after coating tablet uniformly wraps syrup, is then sprinkled into talcum powder, slowly blows at low temperature
Dry, repetitive operation 8-12 times until corner angle disappear.
E6 sugar coating layer: according to sub-coat coating procedure, simple syrup is added in coating pan, (puts on glue with hand when necessary
Leather glove) auxiliary stirring, turn to coating tablet average rate in coating pan after coating tablet uniformly wraps syrup, at low temperature slowly
Drying repeats aforesaid operations 8-12 times, until surface is smooth, smooth, solid.Simple syrup dosage uses first thick rear dilute principle, by
Secondary reduction dosage, makes up the deficiency of sub-coat, and by unilateral filling-in, latter two layers dilute, evens up drawing-down for unilateral.
E7 packet color sugarcoating layer: after completing sugar-coat layer operation, there is fine and smooth bloom in coat tablets, meet unilateral when vapor
There is gloss, sugar colour clothing layer operation can be carried out at this time.Sugar colour is starched and is added in coating pan, coating tablet average rate in coating pan is made
It turns to coating tablet and uniformly wraps sugar colour slurry, until drying at room temperature, repeat aforesaid operations 4-6 times；It is dry to get.
C8 polishing, cool: insect wax be crushed into 80 meshes, start coating pan, be sprinkled into 1.2kg insect wax powder, make sugar-coat
Piece surface-brightening is beautiful, and the sugar coated tablet after coating must reach smooth in appearance, uniform color, inviolateness.By sugar coated tablet from coating
It is transferred to cool room in pot, cool thickness is advisable with 2-3cm, and cool time is 8 hours or more, and cool in the process should be check at any time
Dehumidifier operation conditions.
Performance detection
Detect the aerobic bacterium number of compound jinei jin tablet made from embodiment 1, yeast and mold sum, escherichia coli
Number, bile tolerance Grain-negative bacterium number, sramana's bacterium number, appearance, weight differential, disintegration time limited, the results are shown in Table 1；
Wherein, aerobic bacterium number, the detection method of yeast and mold sum are as follows:
(1) test sample 10g is taken, adds pancreas junket soybean broth that 1:10 test liquid is made to 100ml.10 times are carried out again to pass
Increase dilution and 1:100,1:1000 test liquid is made, aerobic bacteria takes test liquid (1:10,1:100,1:1000) each 1ml to diameter respectively
In the sterilizing plates of 90mm, each dilution grade prepares 2 plates respectively；Yeast and mold takes test liquid (1:10,1:100) each
In the sterilizing plates of 1ml to diameter 90mm, each dilution grade prepares 2 plates respectively.
(2) negative control experiments: after infusing ware to dilutions at different levels, test diluent is drawn with 1 1ml suction pipe
(pancreas junket soybean broth) each 1ml, is injected separately into 4 plates.Wherein make aerobic bacterium number negative control for 2；Another 2 works
Mould, yeast count negative control.
(3) culture medium is poured into: by the pancreas junket soya peptone agar medium of preparatory prepared Aerobic Count；Mould,
The Sabouraud glucose agar of saccharomycete counting when being cooled to about 45 DEG C, pours into above-mentioned each plate about 15~20ml, with
Direction quickly rotates plate clockwise or counterclockwise, mixes test liquid or dilution and culture medium, lets cool.When rotating plate
It is sure not to splash culture medium in ware side and ware lid.
(4) cultivate: unless otherwise specified, Aerobic Count plate is inverted in 30-35 DEG C of incubator and cultivates 3 days.Mould,
Saccharomycete counting plate, which is inverted in 23-28 DEG C of incubator, to be cultivated 5 days, extends to 7 days when necessary.Day by day observation bacterium colony grows feelings
Condition, point meter clump count.
The detection method of escherichia coli number are as follows:
Escherichia coli (Escheriacoli)
(1) test liquid preparation and Zengjing Granule: test sample is taken, according to " non-sterile product limit test of microbe: microorganism
1:10 test liquid is made in counting method (2015 editions general rules 1105 of Chinese Pharmacopoeia).The test liquid for being equivalent to 1g or 1ml test sample is taken, is connect
Kind mixes, 30-35 DEG C of culture 18- to the pancreas junket soya peptone fluid nutrient medium of appropriate volume (verify and determine through method applicability)
24 hours.
(2) it selects and is separately cultured: taking above-mentioned culture 1ml to be seeded in 100ml Mai Kangkai fluid nutrient medium, 42-44
DEG C culture 24-48 hours.Take the streak inoculation of Mai Kangkai liquid culture on maconkey agar culture medium flat plate, 30-35 DEG C is trained
It supports 18-72 hours.
(3) result judges: if there is bacterium colony growth on maconkey agar culture medium flat plate, should be separated, be purified and be suitable for
Discrimination test, confirmation whether be escherichia coli；If sterile length of being born on maconkey agar culture medium flat plate, though or there is a bacterium colony
It grows but qualification result is feminine gender, sentence test sample and escherichia coli is not detected.
The detection method of bile tolerance Grain-negative bacterium number is；
Bile tolerance Gram-negative bacteria (Bile-TolerantGram-NegativeBacteria)
(1) test liquid preparation and Zengjing Granule: test sample is taken, pancreas junket soya peptone fluid nutrient medium is used to shine as diluent
1:10 test liquid is made in " non-sterile product limit test of microbe: microorganism count method (general rule 1105) ".It mixes, 20-25 DEG C
Culture 18-24 hours, incubation time should be such that the bacterium in test sample is thus capable of sufficiently recovering but not be proliferated (about 2 hours).
(2) qualitative test: unless otherwise specified, the above-mentioned pre-culture for being equivalent to 1g or 1ml test sample is taken to be seeded to suitable
The enterobacteriaceae enrichment liquid body culture medium of suitable volume (verify and determine through method applicability), 30-35 DEG C after culture 24-48 hours, stroke
Line is inoculated on purplish red cholate glucose agar medium plate, 30-35 DEG C culture 18-24 hours.If without bacterium colony on plate
Growth, sentences test sample and bile tolerance Gram-negative bacteria is not detected.
(3) quantitative test
A. it selects and is separately cultured: taking and be equivalent to 0.1g, 0.01g and 0.001g (or 0.1ml, 0.01ml, 0.001ml) confession
The pre-culture of test product is seeded to the enterobacteriaceae enrichment liquid body culture medium of appropriate volume (verify and determine through method applicability), 30-
35 DEG C culture 24-48 hours.Above-mentioned each culture streak inoculation is on purplish red cholate glucose agar medium plate, 30-
35 DEG C culture 18-24 hours.
If b. result judges there is bacterium colony growth on purplish red cholate glucose agar medium plate, corresponding to culture tube is sun
Property, it is otherwise feminine gender.According to each culture tube inspection result, bile tolerance gram is contained from 2 difference 1g or 1ml test sample of pharmacopeia table
The possibility bacterium number of negative bacterium.
4, result judges: if having bacterium colony growth on purplish red cholate glucose agar medium plate, corresponding culture tube is
Otherwise the positive is feminine gender.It is blue containing bile tolerance leather from 2 difference 1g or 1ml test sample of pharmacopeia table according to each culture tube inspection result
The possibility bacterium number of family name's negative bacterium.
The detection method of sramana's bacterium number are as follows:
Detection of Salmonella (Salmonella)
1, appropriate volume (classical prescription test sample preparation and Zengjing Granule: is seeded to after taking 10g or 10ml test sample directly to handle
Method applicability verifying determine) pancreas junket soya peptone fluid nutrient medium in, mix, 30-35 DEG C culture 18-24 hours.
2, it selects and is separately cultured: taking above-mentioned culture 0.1ml to be seeded in 10mlRV detection of Salmonella fluid nutrient medium, 30-
35 DEG C culture 18-24 hours.Take a small amount of RV detection of Salmonella liquid culture streak inoculation in xylose-lysine-desoxycholate agar
On culture medium flat plate, 30-35 DEG C culture 18-48 hours.Detection of Salmonella is in xylose-lysine-desoxycholate agar medium plate
Upper well-grown, bacterium colony are pale red or colourless, transparent or semitransparent, center with or without black.Doubtful bacterium is selected with transfer needle
Fall on xylose-lysine-desoxycholate agar medium plate, 30-35 DEG C culture 18-24 hours, or using other be suitable for
Method is further identified.
3, result judges: if having doubtful bacterium colony to grow on xylose-lysine-desoxycholate agar medium plate, and three
The inclined-plane of sugared iron agar medium is red, bottom is yellow or inclined-plane yellow, bottom yellow or black, answers further progress
Suitable qualification test, whether confirmation is detection of Salmonella.If there is no bacterium colony growth on plate, or there must be bacterium colony to grow but identify knot
Fruit is that negative or triple sugar-iron-agar medium inclined-plane has no red, bottom has no yellow；Or inclined-plane yellow, bottom have no yellow
Color or black sentence test sample and detection of Salmonella are not detected.
The detection method of appearance are as follows: visually observation；
The detection method of weight differential are as follows: every 2 hours primary to weighing tablets made from the batch with balance, the equal piece of criticize flat
Weight=(X1+X2+X3+……Xn)/n；
In formula: Xn indicates the average slice weight of n-th monitoring；N indicates monitoring number；
The detection method of disintegration time limited are as follows: hanging basket is hung on metallic support by the stainless steel shaft of upper end, is immersed
In 1000ml beaker, and the sieve that adjusts hanging basket position when making its decline, away from beaker bottom 25mm, filling temperature in beaker is 37 DEG C
± 1 DEG C of water, sieve is at the 15mm of underwater when adjusting height of water level rises hanging basket.Test sample 6 are taken, sets above-mentioned hang respectively
In the glass tube of basket, starting disintegration tester is checked.It is first checked 2 hours in hydrochloric acid solution (9 → 1000), every must not have
Crack, disintegration or ruckbildung；It is taken out after by hanging basket, after being washed with a small amount, every pipe is added 1 piece of baffle, then according to the above method
It is checked in phosphate buffer.
1 the performance test results of table
As shown in Table 1, the aerobic bacterium number of compound jinei jin tablet made from embodiment 1 is 480cfu/g, yeast and mold
Sum is 37cfu/g, and escherichia coli and detection of Salmonella are not detected, and bile tolerance Grain-negative bacterium number is 61cfu/g；Appearance has light
Pool, no wax spot, no piebald, color uniformity, weight differential are -3.4%~3.9%；In hydrochloric acid solution in 2 hours not
Disintegration, is all disintegrated in phosphate buffer 30 minutes.Thus it proves, compound endothelium corneum gigeriae galli made from method of the invention
The content of microorganisms of piece is low, and uniformity of weight is good.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (8)
1. compound jinei jin tablet, which is characterized in that including following components: endothelium corneum gigeriae galli, Medicated Leaven, sucrose, adhesive, magnesium stearate
And coating material.
2. compound jinei jin tablet according to claim 1, which is characterized in that described adhesive is by cornstarch, gelatin and pure
Change water to be prepared.
3. compound jinei jin tablet according to claim 2, which is characterized in that described adhesive the preparation method comprises the following steps: purified water
It is heated to boiling, gelatin is added, the slurrying cornstarch soaked is added after dissolving, stirring is boiled 2 minutes, and heating is stopped, cold
But.
4. according to claim 1, the 2 or 3 compound jinei jin tablet, which is characterized in that the coating material is by sucrose, talcum
Powder, insect wax, lemon yellow and gelatin composition.
5. compound jinei jin tablet according to claim 4, which is characterized in that the coating material is white by sucrose, talcum powder, worm
Wax, lemon yellow and gelatin are formed according to the mass ratio of 210-270:220-260:1-1.5:0.1-0.2:2-2.5.
6. according to claim 1, the compound jinei jin tablet of 2,3,4 or 5, which is characterized in that in terms of mass parts, proportion relation
For 100-105 parts of endothelium corneum gigeriae galli, 195-200 parts of Medicated Leaven, 150-200 parts of sucrose, 40-45 parts of adhesive, 2-5 parts of magnesium stearate
With 500-505 parts of coating material.
7. the preparation method of any one of the claim 1-6 compound jinei jin tablet, which comprises the following steps: chicken
Interior gold, Medicated Leaven and sucrose pulverize and sieve and mix, and adhesive granulation, dry, whole grain are then added, then addition is hard into particle
Fatty acid magnesium is uniformly mixed, tabletting, coating, polishing, and cool.
8. preparation method according to claim 7, which is characterized in that temperature≤80 DEG C of the drying, time 60-80
Minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811181542.8A CN109010381A (en) | 2018-10-11 | 2018-10-11 | Compound jinei jin tablet and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811181542.8A CN109010381A (en) | 2018-10-11 | 2018-10-11 | Compound jinei jin tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN109010381A true CN109010381A (en) | 2018-12-18 |
Family
ID=64616133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201811181542.8A Pending CN109010381A (en) | 2018-10-11 | 2018-10-11 | Compound jinei jin tablet and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742842A (en) * | 2005-10-08 | 2006-03-08 | 山东仙河药业有限公司 | External-use plaster for treating mumps |
| CN101940602A (en) * | 2009-07-08 | 2011-01-12 | 江西施美制药有限公司 | Pediatric compound chicken's gizzard-membrane chewable tablets and preparation method thereof |
-
2018
- 2018-10-11 CN CN201811181542.8A patent/CN109010381A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742842A (en) * | 2005-10-08 | 2006-03-08 | 山东仙河药业有限公司 | External-use plaster for treating mumps |
| CN101940602A (en) * | 2009-07-08 | 2011-01-12 | 江西施美制药有限公司 | Pediatric compound chicken's gizzard-membrane chewable tablets and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 傅超美等: "《中药药剂学》", 31 August 2014, 中国医药科技出版社 * |
| 孟胜男等: "《药剂学实验指导》", 28 February 2016, 中国医药科技出版社 * |
| 柏正平: "《中成药家庭使用全解》", 31 January 2013, 人民军医出版社 * |
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Application publication date: 20181218 |