CN109006845B - Emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide and preparation method thereof - Google Patents
Emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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Abstract
The invention discloses an emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide and a preparation method thereof. The pesticide with high photolysis resistance and good slow-release capability is prepared by respectively dissolving and emulsifying emamectin benzoate and lignosulfonate and then mixing the solutions, adding a granulation auxiliary agent and a thickening agent into the mixed solution, and carrying out emulsification and dispersion by combining low-temperature ultrasound. The emamectin benzoate nanoparticle pesticide has the decomposition rate of about 30 percent after being irradiated by sunlight for 75 hours, and has excellent photolysis resistance.
Description
Technical Field
The invention relates to the technical field of pesticides, and particularly relates to an emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide and a preparation method thereof.
Background
With the development of agricultural production in China, the problem of pesticide residue is more and more serious due to the increase of the usage amount of pesticide, and great influence is brought to the environmental ecology and the health of people. Besides accelerating the research and development of novel high-efficiency and low-toxicity pesticide products, the dosage of the pesticide is reduced and the pesticide effect of the existing pesticide is fully exerted by improving the dosage form and the formula of the existing pesticide, which is another effective way for the sustainable development of modern agriculture and environmental protection.
The emamectin benzoate is a novel high-efficiency semi-synthetic antibiotic insecticide and has the characteristics of high efficiency, low toxicity, low residue, no public nuisance and other biological pesticides. At present, the pesticide composition is widely applied to prevention and control of various pests on crops such as vegetables, fruit trees, cotton, rice, soybeans, tobacco and the like. Because emamectin benzoate is slightly soluble in water, its use in agricultural fields is generally applied by making it into emulsifiable concentrates. However, since emamectin benzoate is easily decomposed by light, the storage stability is enhanced by adding a certain amount of a stabilizer to the preparation of emulsifiable concentrates, but the photolysis resistance is not effectively improved due to the dilution of the preparation after application. In the agricultural production process, the method can only compensate by increasing the application amount and repeatedly applying, and the consequence of the method is that the use cost in the agricultural production process is increased due to the excessive use of the pesticide, and meanwhile, a large amount of pesticide molecules are randomly discharged into the surrounding environment, so that the environmental ecology is damaged and influenced.
The nano-particle pesticide appearing in recent years is a novel pesticide preparation with development prospect, on one hand, the nano-particle pesticide has the function of slowing down the release of the pesticide, and prolongs the release time of the pesticide with the same dosage, thereby reducing the dosage and application frequency of the pesticide and reducing the pollution to the environment ecology; on the other hand, by wrapping the pesticide active molecules, the decomposition and the loss of the pesticide can be reduced, and the stability of the pesticide is improved.
The invention patent CN 101830760A describes an emamectin benzoate-algae slow-release type microcapsule pesticide and a preparation method thereof, and the obtained preparation has a slow-release function, prolongs the use duration of the emamectin benzoate, but does not solve the photolysis problem of the emamectin benzoate after application; the invention patent CN 103168773A discloses a method for preparing pesticide water-suspended nano-capsules based on a microemulsion template, which can be used for preparing efficient cyhalothrin microemulsion and also does not solve the problem of photolysis of emamectin benzoate after application; the invention patent CN106417269A discloses a water-based nanoparticle water dispersion preparation of a fat-soluble pesticide and a preparation method thereof, the method can be applied to pesticide avermectin, but the pesticide prepared by the method has low drug-loading rate and poor stability. In addition, there are reports of nanoparticle slow-release pesticides in literature, and Dongsheng Yang et al report a solidified nanoemulsion method for directly preparing emamectin benzoate nanoparticle formulations (Dongsheng Yang, et al, Journal of Nanomaterials, Volume 2017, Article ID 6560780); yonghong Deng et al prepared a nitrogen-containing lignin vacuum colloidal particle, and utilized it to wrap avermectin, so that the anti-photolysis ability of avermectin was greatly improved (Yonghong Deng, et al, Industrial Crops & Products,2016,87, 191-doped 197). The document is to structurally modify lignin by diazotization, introduce anilino group on the benzene ring of lignin, and then polymerize to form a capsule to wrap avermectin, but because of the introduction of anilino group, the original natural degradation of lignin, no pollution to the environment, and poor stability were lost.
However, the currently disclosed emamectin benzoate nanoparticle preparation has the defects of low drug loading, poor stability, complex preparation process, high cost, weak photolysis resistance and the like. Therefore, it is necessary to research and develop a emamectin benzoate nanoparticle pesticide product which has the advantages of simple preparation method, high drug loading amount, low cost, degradability, no pollution and good photolysis resistance and slow release performance. .
Disclosure of Invention
Aiming at the problems in the prior art, the preparation method of the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide is provided, the method is high in drug loading, the preparation process is simple and feasible, and the obtained emamectin benzoate nanoparticle has good photolysis resistance and slow-release performance.
The technical scheme of the invention is as follows:
an emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide comprises the following raw materials in parts by weight: 1-40 parts of emamectin benzoate, 1-40 parts of solid granulating agent, 1-6 parts of surfactant and 0.5-0.8 part of thickening agent.
As a further improvement of the technical scheme, the emamectin benzoate nanoparticle anti-photolysis slow-release pesticide is characterized in that the solid granulating agent is lignosulfonate.
As a further improvement of the technical scheme, the above-mentioned emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide, the surfactant may be one or more of tween, lecithin, alkylphenol polyoxyethylene ether, high-carbon fatty alcohol polyoxyethylene ether, fatty acid polyoxyethylene ester, sorbitan ester, sucrose ester, alkylolamide and styrylphenol polyoxyethylene ether.
As a further improvement of the technical scheme, the above-mentioned emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide has the thickener which is one or more of sodium alginate, chitin, gum arabic, xanthan gum, methyl cellulose, hydroxyethyl cellulose, various modified starches, gelatin, soybean protein glue, agar, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide and polyacrylate copolymer emulsion.
The preparation method of the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide comprises the following steps of weighing raw materials in parts by weight:
(1) dissolving the solid granulating agent in water to obtain a solid granulating agent solution after complete dissolution, and standing for later use;
(2) adding a surfactant into the solid granulating agent solution, and then stirring and emulsifying for 10-60 minutes to obtain a solid granulating agent emulsion;
(3) dissolving emamectin benzoate in an organic solvent, stirring for dissolving, adding the residual surfactant, and performing ultrasonic treatment for 10-60 minutes to obtain an emamectin benzoate emulsion;
(4) gradually adding the emamectin benzoate emulsion into the solid granulating agent emulsion under high-speed stirring, and continuously stirring for 5-120 minutes to obtain a mixture 1;
(5) carrying out low-temperature ultrasonic treatment on the mixture 1 for 5-120 minutes, and then continuously stirring for 5-120 minutes to obtain a mixture 2;
(6) and adding a thickening agent into the mixture 2, and then continuing stirring for 1-10 hours to finally obtain the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide.
Further, the ultrasonic frequency in the step (3) is 30000-40000 Hz.
Further, the low-temperature ultrasound in the step (5) is performed at an ultrasound frequency of 25000 and 35000Hz at an ambient temperature of 0-10 ℃.
The application of the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide is an application in the field of sustained-release pesticides.
The invention has the following beneficial effects:
1. the invention utilizes the combination of positively charged emamectin benzoate cations and negatively charged sodium lignosulfonate sulfonate anions in a self-assembly form to form the emamectin benzoate nano-particles by double emulsification dispersion and then mixing, and then adds a granulation auxiliary agent and a thickening agent to ensure that the preparation is stably prepared into the anti-photolysis slow-release pesticide of the emamectin benzoate nano-particles. The preparation method of the emamectin benzoate nanoparticle pesticide provided by the invention has the advantages of high drug loading, controllability and simple preparation process.
2. Because the solid granulating agent of the preparation is lignosulfonate, the main component of the preparation is a polyphenol compound, and the preparation has good oxidation resistance and photolysis resistance. Therefore, the emamectin benzoate nanoparticle pesticide disclosed by the invention has good photolysis resistance.
3. Because the emamectin benzoate positive ions and the lignosulfonate negative ions in the emamectin benzoate nano-particle pesticide form nano-pesticide particles in an ion adsorption and accumulation mode, didecyl phosphate diester salts in the granulating auxiliary agent have lower surface tension, good wettability and emulsibility, and have the functions of capacity increasing and antistatic to a solution; the anionic polyacrylamide and the sodium carboxymethyl cellulose have better functions of adhesion, thickening and anti-coagulation. Due to the addition of the auxiliary agent, the prepared nano particles are more compact, and more excellent photolysis resistance is obtained.
4. The invention has the more obvious advantages that the main matrix material is lignosulfonate, which is a byproduct in the papermaking process, the resource is rich, and the cost is low. The sulfonated lignin can be biologically degraded and does not pollute the environment. Meanwhile, the preparation of the invention adopts water as the main solvent and has low price.
5. The emamectin benzoate nanoparticle photolysis-resistant controlled-release pesticide taking lignosulfonate as a matrix material also has the advantages of simple preparation method, small equipment investment and no generation of three wastes in the production process.
Drawings
Figure 1 is a release curve of emamectin benzoate nanoparticle pesticide components.
FIG. 2 is a decomposition curve of emamectin benzoate nanoparticle pesticide against ultraviolet light.
FIG. 3 is a decomposition curve of emamectin benzoate nanoparticle pesticide against sunlight.
Detailed Description
The following claims are presented to further illustrate the invention in conjunction with the detailed description, and any limited number of modifications that can be made within the scope of the claims are intended to be within the scope of the invention.
EXAMPLE 1 preparation of 1% Emamectin benzoate nanoparticle photolytic resistant controlled release pesticide
The preparation method of the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide comprises the following steps:
(1) weighing 6Kg of sodium lignosulfonate to be dissolved in 200L of distilled water, stirring at room temperature for 10h to obtain a sodium lignosulfonate solution, and standing for later use.
(2) Taking 100L of the sodium lignosulphonate solution obtained in the step (1), adding tween-802 Kg, and stirring for 10min to obtain an emulsion;
(3) weighing 2.6Kg of emamectin benzoate, dissolving the emamectin benzoate in 30L of ethyl acetate, stirring and dissolving, and then carrying out ultrasonic treatment in an ice-water bath for 10 minutes to obtain an emulsion containing the emamectin benzoate;
(4) gradually adding the emulsion containing emamectin benzoate in the step (3) into the emulsion in the step (2) under high-speed stirring, and stirring for 10min to obtain a coffee mixture 1;
(5) performing ultrasonic treatment on the mixture 1 obtained in the step (4) in an ice bath (2 ℃) for 5min, and then continuing stirring for 5min to obtain a mixture 2;
(6) and (3) adding 15Kg of 3% sodium alginate solution into the mixture 2 obtained in the step (5), and continuing stirring for 1h to finally obtain the 1% emamectin benzoate nanoparticle photolysis-resistant controlled-release pesticide.
Example 2 preparation of 3% Emamectin benzoate nanoparticle photolytic resistant controlled release pesticide
(1) Weighing 12Kg of sodium lignosulfonate to be dissolved in 300L of distilled water, stirring at room temperature for 10h to obtain a sodium lignosulfonate solution, and standing for later use.
(2) Taking 100L of the sodium lignosulphonate solution in the step (1), adding 2Kg of styryl phenol polyoxyethylene ether, and stirring at a high speed for 20min to obtain a light brown emulsion;
(3) weighing 7.6Kg of emamectin benzoate, dissolving in 40L of ethyl acetate, stirring for dissolving, and performing ultrasonic treatment in ice bath for 25 minutes to obtain an emulsion containing emamectin benzoate;
(4) slowly adding the emulsion containing emamectin benzoate in the step (3) into the emulsion in the step (2), and stirring for 40min to obtain a mixture 1;
(5) performing ultrasonic treatment on the mixture 1 in the step (4) in an ice bath for 40min, and then continuing stirring for 40min to obtain a mixture 2;
(6) and (3) adding 20Kg of 4% sodium alginate solution into the mixture 2 obtained in the step (5), and continuously stirring for 3 hours to obtain the 5% emamectin benzoate nanoparticle photolysis-resistant controlled-release pesticide.
Example 3 preparation of 5% Emamectin benzoate nanoparticle photolytic resistant controlled release pesticide
(1) Weighing 15Kg of sodium lignosulfonate to dissolve in 300L of distilled water, stirring at room temperature for 10h to dissolve to obtain sodium lignosulfonate solution, and standing for later use.
(2) Taking 150L of the sodium lignosulphonate solution in the step (1), adding 3Kg of alkylphenol polyoxyethylene, and stirring at a high speed for 30min to obtain a light brown emulsion;
(3) weighing 22.6Kg of emamectin benzoate, dissolving in 75L of ethyl acetate, stirring for dissolving, and performing ultrasonic treatment in ice bath for 30 minutes to obtain an emulsion containing emamectin benzoate;
(4) gradually adding the emulsion containing emamectin benzoate in the step (3) into the emulsion obtained in the step (2) under high-speed stirring, and stirring for 20min to obtain a coffee mixture 1;
(5) performing ultrasonic treatment on the mixture 1 in the step (4) in an ice bath for 80min, and then continuing stirring for 80min to obtain a mixture 2;
(6) and (3) adding 28.3Kg of 4% sodium alginate solution into the mixture 2 obtained in the step (5), and continuously stirring for 6 hours to obtain the 5% emamectin benzoate nanoparticle photolysis-resistant controlled-release pesticide.
Example 4 preparation of 10% Emamectin benzoate nanoparticle photolytic resistant controlled release pesticide
(1) Weighing 20Kg of sodium lignosulfonate, dissolving in 300L of distilled water, stirring at room temperature for 10h to obtain sodium lignosulfonate solution, and standing for later use;
(2) taking 100L of the sodium lignosulfonate solution in the step (1), adding 2Kg of high-carbon fatty alcohol polyoxyethylene ether, and stirring at a high speed for 30min to obtain a light brown emulsion;
(3) weighing 24.1Kg of emamectin benzoate, dissolving in 50L of ethyl acetate, stirring for dissolving, and performing ultrasonic treatment in ice bath for 35 minutes to obtain an emulsion containing emamectin benzoate;
(4) gradually adding the emulsion containing emamectin benzoate in the step (3) into the emulsion in the step (2) under high-speed stirring, and stirring for 30min to obtain a coffee mixture 1;
(5) performing ultrasonic treatment on the mixture 1 in the step (4) in an ice bath for 100min, and then continuing stirring for 100min to obtain a mixture 2;
(6) and (3) adding 19Kg of 3% xanthan gum solution into the mixture 2 obtained in the step (5), and continuing stirring for 9 hours to obtain the 10% emamectin benzoate nanoparticle photolysis-resistant controlled-release pesticide.
Example 5 preparation of 15% Emamectin benzoate nanoparticle photolytic resistant controlled release pesticide
(1) Weighing 30Kg of sodium lignosulfonate, dissolving in 300L of distilled water, stirring at room temperature for 10h to obtain a sodium lignosulfonate solution, and standing for later use;
(2) taking 100L of the sodium lignosulphonate solution in the step (1), adding tween-802 Kg, and stirring at a high speed for 30min to obtain a light brown emulsion;
(3) weighing 46Kg of emamectin benzoate, dissolving in 70L of ethyl acetate, stirring for dissolving, and carrying out ultrasonic treatment in ice bath for 40 minutes to obtain an emulsion containing the emamectin benzoate;
(4) gradually adding the emamectin benzoate emulsion obtained in the step (3) into the emulsion obtained in the step (2) under high-speed stirring, and stirring for 20min to obtain a coffee mixture 1;
(5) performing ultrasonic treatment on the mixture obtained in the step (4) in an ice bath for 120min, and then continuing stirring for 120min to obtain a mixture 2;
(6) and (4) adding 18Kg of 5% sodium alginate solution into the mixture 2 obtained in the step (5), and continuously stirring for 10 hours to obtain the 15% emamectin benzoate nanoparticle photolysis-resistant controlled-release pesticide.
Divinylon-acetate nanoparticle pesticide ingredient release test
2g of the 3% emamectin benzoate nanoparticle pesticide photolysis-resistant controlled-release granules prepared in example 2 and 60mg of emamectin benzoate raw drug are weighed respectively, placed in dialysis bags respectively, then placed in 1000mL of 30% ethanol solution, and naturally diffused and separated at 25 ℃. At certain time intervals, 5mL of the solution was sampled and simultaneously 5mL of 30% ethanol was added, the concentration of emamectin benzoate in the solution was analyzed by HPLC, the cumulative release rate was calculated, and a release kinetics curve of the cumulative release rate of emamectin benzoate versus time was prepared therefrom, as shown in FIG. 1.
As can be seen from fig. 1, after 60 hours of release, the release rate of the original emamectin benzoate of the control sample is greater than 80%, while the release rate of the emamectin benzoate nanoparticle pesticide of the invention is lower than 30%, which indicates that the emamectin benzoate nanoparticle pesticide of the invention has good slow release performance.
Photodecomposition test of tretinoin salt nanoparticle pesticide
Photolysis test 1
The decomposition test of the emamectin benzoate nanoparticle pesticide against ultraviolet light comprises the following steps:
weighing 2g of the 1% emamectin benzoate nanoparticle pesticide in example 1, and placing the weighed pesticide in a 24-hole plate; 20m of emamectin benzoate is weighed and dissolved in 2mL of methanol to serve as a control, and a transparent film is covered. Then respectively irradiating under an ultraviolet lamp (38W, wavelength 254 nm). At certain time intervals, samples are respectively taken and analyzed for the content of the emamectin benzoate by high pressure liquid chromatography, the decomposition rate of the emamectin benzoate at different time nodes is calculated, and a kinetic curve of the decomposition rate of the emamectin benzoate and time is made according to the calculation result, as shown in figure 2.
As can be seen from fig. 2, under ultraviolet irradiation for 70 hours, the decomposition rate of the original emamectin benzoate of the control sample is 80%, while the decomposition rate of the emamectin benzoate nanoparticle pesticide of the present invention is about 45%, which indicates that the emamectin benzoate nanoparticle pesticide of the present invention has significant ultraviolet photolysis resistance.
Photolysis test 2
The test of sunlight irradiation decomposition resistance of the emamectin benzoate nanoparticle pesticide:
1g of 5% emamectin benzoate nanoparticle pesticide of example 3 was weighed out in a 24-well plate and then air dried, and 50mg of emamectin benzoate bulk drug powder was weighed out as a control and then placed under sunlight. The time period of solar irradiation was selected from 9 am to 4 pm, and the sample was wrapped with black paper during the period of no solar irradiation. At certain time intervals, samples are respectively taken and analyzed for the content of the emamectin benzoate by ultraviolet-visible spectrum, the decomposition rate of the emamectin benzoate at different time nodes is calculated, and a kinetic curve of the decomposition rate of the emamectin benzoate and time is made according to the calculation result, as shown in figure 3. (Note: test time is 8-10 months.)
As can be seen from fig. 3, when the control sample is irradiated by sunlight for 75 hours, the decomposition rate of the original emamectin benzoate is 75%, and the decomposition rate of the emamectin benzoate nanoparticle pesticide of the present invention is about 30%, which indicates that the emamectin benzoate nanoparticle pesticide of the present invention has a significant resistance to photolysis by sunlight.
Claims (5)
1. The emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide is characterized by comprising the following raw materials in parts by weight: 1-40 parts of emamectin benzoate, 1-40 parts of solid granulating agent, 1-6 parts of surfactant and 0.5-0.8 part of thickening agent; the solid granulating agent is lignosulfonate; the surfactant is one or more of tween, lecithin, alkylphenol polyoxyethylene ether, high-carbon fatty alcohol polyoxyethylene ether, fatty acid polyoxyethylene ester, sorbitan ester, sucrose ester, alkylolamide and styrylphenol polyoxyethylene ether;
the preparation method of the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide comprises the following steps of weighing raw materials in parts by weight:
(1) dissolving the solid granulating agent in water to obtain a solid granulating agent solution after complete dissolution, and standing for later use;
(2) adding a surfactant into the solid granulating agent solution, and then stirring and emulsifying for 10-60 minutes to obtain a solid granulating agent emulsion;
(3) dissolving emamectin benzoate in an organic solvent, stirring for dissolving, adding the residual surfactant, and performing ultrasonic treatment for 10-60 minutes to obtain an emamectin benzoate emulsion;
(4) gradually adding the emamectin benzoate emulsion into the solid granulating agent emulsion under high-speed stirring, and continuously stirring for 5-120 minutes to obtain a mixture 1;
(5) carrying out low-temperature ultrasonic treatment on the mixture 1 for 5-120 minutes, and then continuously stirring for 5-120 minutes to obtain a mixture 2;
(6) and adding a thickening agent into the mixture 2, and then continuing stirring for 1-10 hours to finally obtain the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide.
2. The emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide as claimed in claim 1, wherein the thickener is one or more of sodium alginate, chitin, gum arabic, xanthan gum, methyl cellulose, hydroxyethyl cellulose, modified starch, gelatin, soybean protein glue, agar, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide and polyacrylate copolymer emulsion.
3. The preparation method of the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide as claimed in claim 1 or 2, which is characterized in that the raw materials are weighed according to parts by weight and then prepared according to the following steps:
(1) dissolving the solid granulating agent in water to obtain a solid granulating agent solution after complete dissolution, and standing for later use;
(2) adding a surfactant into the solid granulating agent solution, and then stirring and emulsifying for 10-60 minutes to obtain a solid granulating agent emulsion;
(3) dissolving emamectin benzoate in an organic solvent, stirring for dissolving, adding the residual surfactant, and performing ultrasonic treatment for 10-60 minutes to obtain an emamectin benzoate emulsion;
(4) gradually adding the emamectin benzoate emulsion into the solid granulating agent emulsion under high-speed stirring, and continuously stirring for 5-120 minutes to obtain a mixture 1;
(5) carrying out low-temperature ultrasonic treatment on the mixture 1 for 5-120 minutes, and then continuously stirring for 5-120 minutes to obtain a mixture 2;
(6) and adding a thickening agent into the mixture 2, and then continuing stirring for 1-10 hours to finally obtain the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide.
4. The method for preparing the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide as claimed in claim 3, wherein the ultrasonic frequency in the step (3) is 30000-40000 Hz.
5. The method for preparing the emamectin benzoate nanoparticle photolysis-resistant slow-release pesticide as claimed in claim 3, wherein the low-temperature ultrasound in the step (5) is performed at an ultrasonic frequency of 25000 and 35000Hz under the condition that the environmental temperature is 0-10 ℃.
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| CN110946133B (en) * | 2020-02-17 | 2022-03-25 | 广西田园生化股份有限公司 | Nano photolysis-resistant controlled-release pesticide with lignin as coating matrix and preparation method thereof |
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| CN114262449A (en) * | 2021-12-27 | 2022-04-01 | 南宁师范大学 | Lignin-emamectin benzoate conjugate, preparation method, pesticide and application thereof |
| CN114885953A (en) * | 2022-05-27 | 2022-08-12 | 广西田园生化股份有限公司 | Emamectin benzoate-sodium alginate nanoparticle slow-release pesticide and preparation method thereof |
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