CN102599165A - Azoxystrobin microcapsule suspending agent and preparation method thereof - Google Patents
Azoxystrobin microcapsule suspending agent and preparation method thereof Download PDFInfo
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- CN102599165A CN102599165A CN2012100394485A CN201210039448A CN102599165A CN 102599165 A CN102599165 A CN 102599165A CN 2012100394485 A CN2012100394485 A CN 2012100394485A CN 201210039448 A CN201210039448 A CN 201210039448A CN 102599165 A CN102599165 A CN 102599165A
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- fluoxastrobin
- urea
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- azoxystrobin
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- 239000003094 microcapsule Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000000375 suspending agent Substances 0.000 title abstract description 12
- 239000005730 Azoxystrobin Substances 0.000 title abstract description 9
- WFDXOXNFNRHQEC-GHRIWEEISA-N Azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 title abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 13
- 239000002270 dispersing agent Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000008367 deionised water Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 9
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- 239000000839 emulsion Substances 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 6
- 239000002775 capsule Substances 0.000 claims abstract description 5
- 239000005784 Fluoxastrobin Substances 0.000 claims description 40
- UFEODZBUAFNAEU-NLRVBDNBSA-N fluoxastrobin Chemical compound C=1C=CC=C(OC=2C(=C(OC=3C(=CC=CC=3)Cl)N=CN=2)F)C=1C(=N/OC)\C1=NOCCO1 UFEODZBUAFNAEU-NLRVBDNBSA-N 0.000 claims description 40
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 30
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 28
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 28
- 238000003756 stirring Methods 0.000 claims description 22
- 239000000725 suspension Substances 0.000 claims description 19
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 239000004202 carbamide Substances 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 14
- 206010011732 Cyst Diseases 0.000 claims description 12
- 229920001730 Moisture cure polyurethane Polymers 0.000 claims description 10
- 229920001807 Urea-formaldehyde Polymers 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 230000001105 regulatory Effects 0.000 claims description 8
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N Diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 238000005352 clarification Methods 0.000 claims description 4
- 230000000295 complement Effects 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000005755 formation reaction Methods 0.000 claims description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N o-xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 3
- JHIVVAPYMSGYDF-UHFFFAOYSA-N Cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N Dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims description 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N Diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2R)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 2
- 239000008079 hexane Substances 0.000 claims description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N n-methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N n-pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 claims description 2
- 238000006068 polycondensation reaction Methods 0.000 claims description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 2
- 238000005070 sampling Methods 0.000 claims description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 2
- 239000001632 sodium acetate Substances 0.000 claims description 2
- 235000017281 sodium acetate Nutrition 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims 1
- 239000000575 pesticide Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 4
- 239000002552 dosage form Substances 0.000 abstract description 3
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 231100000605 Toxicity Class Toxicity 0.000 abstract 1
- 239000004563 wettable powder Substances 0.000 abstract 1
- 239000003905 agrochemical Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 4
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 230000002045 lasting Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000000607 poisoning Effects 0.000 description 3
- 231100000572 poisoning Toxicity 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 240000008067 Cucumis sativus Species 0.000 description 2
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 2
- 241000221785 Erysiphales Species 0.000 description 2
- 241000936613 Peronospora farinosa Species 0.000 description 2
- 241000233647 Phytophthora nicotianae var. parasitica Species 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 230000000249 desinfective Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- LQAQMOIBXDELJX-UHFFFAOYSA-N 2-methoxyprop-2-enoic acid Chemical compound COC(=C)C(O)=O LQAQMOIBXDELJX-UHFFFAOYSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 240000005781 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000233652 Chytridiomycota Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 240000001016 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 240000008529 Triticum aestivum Species 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000009754 grape Nutrition 0.000 description 1
- 235000012333 grape Nutrition 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000000749 insecticidal Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000003449 preventive Effects 0.000 description 1
- 230000002035 prolonged Effects 0.000 description 1
- 210000000697 sensory organs Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002459 sustained Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 235000021307 wheat Nutrition 0.000 description 1
Abstract
The invention discloses an Azoxystrobin microcapsule suspending agent and a preparation method of the Azoxystrobin microcapsule suspending agent. The Azoxystrobin microcapsule suspending agent is composed of the following components in percentage by weight: 1-10% of Azoxystrobin, 3-20% of capsule core solvent, 5-20% of capsule wall material, 1-10% of emulsifying agent, 1-5% of dispersant, 0.5-7% of antifreezing agent, 0.1-10% of pH regulator and the balance of deionized water. The invention also discloses a preparation method of the Azoxystrobin microcapsule suspending agent. According to the invention, Azoxystrobin is prepared into a new dosage form, the defects of oil emulsion, wettable powder, suspending agent and other dosage forms are overcome, the use cost of the farmer is reduced, the environmental pollution, the pesticide toxicity and the product cost are also reduced, and the safety and effect of the pesticide are improved.
Description
Technical field
The present invention relates to a kind of disinfectant use in agriculture and preparation method thereof, a kind of specifically Fluoxastrobin micro-capsule suspension and preparation method thereof.
Background technology
Chemical control is the important means of human control agricultural damage by disease and insect; Chemical pesticide plays important effect to the increasing both production and income that guarantees agricultural; Yet the use of agricultural chemicals when ensureing that grain security is produced, has also brought a series of environment and social concerns such as residual, pollution.Only be because chemical pesticide itself, and be to a great extent because the formulations of pesticide are processed and application process is unreasonable causes.It is reported that the availability of conventional type agricultural chemicals has only 20%～30%, and percent of loss by all means is up to 50%～60%, this not only is a kind of waste economically, and has caused large-scale environmental pollution.Therefore, develop safety, high-efficiency environment friendly, prolongation lasting period, alleviate poisoning, reduce the novel form preparation residual, that increase the range of application of agricultural chemicals of agricultural chemicals in environment and become one of developing direction of the following formulations of pesticide.The pesticide micro capsule suspending agent is to utilize capsule-core that microencapsulation technology will contain former medicine to be encapsulated in the suspending agent of the fine particle that forms in the special cyst material, and the capsule diameter of agricultural chemicals microcapsule suspending agent is generally 1～20 μ m.The agricultural chemicals microcapsule suspending agent is compared following advantage with conventional dosage forms: prolonged the lasting period of agricultural chemicals, the stability that has improved active component, active substance be wrapped in improved in the cyst wall safety, effectively reduce former medicine composition to the stimulus to the sense organ of human body, reduce poisoning, help the composite, friendly more of agricultural chemicals environment to crop.
Fluoxastrobin is the cruel series bactericidal agent of methoxy acrylic acid; Efficiently, wide spectrum, nearly all mycota (Ascomycotina, Basidiomycotina, Mastigomycotina and Deuteromycotina) disease such as powdery mildew, rust, glume blight, net blotch, downy mildew, rice blast etc. are all had good activity.Have protection, treat, root out, infiltration, systemic activity, be mainly used in cereal paddy rice, peanut, grape, potato, fruit tree, vegetables, coffee, lawn etc.
At present; Mostly the Fluoxastrobin formulation of producing and using is suspending agent and missible oil, also has the azoxystrobin water emulsion prescription open, but existing azoxystrobin water emulsion still need use a certain amount of aromatic hydrocarbons organic solvent; And do not add suitable builder; And control efficiency is relatively poor, and is short when drug effect continues, and the Fluoxastrobin application concentration is big, the control cost is high.The Fluoxastrobin micro-capsule suspension can prolong the lasting period, overcomes pest resistance to insecticide, little to environmental pressure, economize on resources, help the sustainable development of agricultural and the protection of environment.
Summary of the invention
The purpose of this invention is to provide a kind of Fluoxastrobin micro-capsule suspension and preparation method thereof, solve the blank of present Fluoxastrobin microcapsule formulations suspending agent,, serve agricultural production for pesticide industry provides a kind of novel form and new product.
The present invention realizes through following technical scheme: a kind of Fluoxastrobin micro-capsule suspension; Form by following components in weight percentage: Fluoxastrobin 1%～10%, capsule-core solvent 3%～20%, cyst material 5%～20%, emulsifier 1%～10%; Dispersant 1%～5%; Antifreezing agent 0.5%～7%, pH regulator agent 0.1%～10%, surplus is a deionized water.
Wherein said capsule-core solvent is one or more in dimethyl formamide, ethanol, isopropyl alcohol, n-butanol, hexane, n-octyl alcohol, n-amyl alcohol, acetone, cyclohexanone, xylol, ethyl acetate, N-Methyl pyrrolidone, diethyl phthalate, acetonitrile, carrene, the dibutyl phthalate.
Described cyst material is the urea resin prepolymer aqueous solution, is to be mixed with weight ratio 1:1.5～1:2.5 by urea and formaldehyde, obtains through polycondensation reaction.
Described emulsifier is one or more in agricultural newborn 33#, 34#, 500#, 600#, 700#, NP-10, PNP-10, EL-40,1601#, 2000#, PF-690, BY-130, the tween-120.
Described dispersant is one or more in SOPA-270, dispersant NNO, sodium lignin sulfonate, the dispersant 2700.
Described antifreezing agent is one or more in ethylene glycol, propane diols, glycerine, the diethylene glycol.
Described pH regulator agent is sodium hydroxide or acetate.
The present invention is a kind of Fluoxastrobin micro-capsule suspension that adopts the situ aggregation method preparation, and its preparation method is following:
(1) urea is dissolved in the formaldehyde, the weight ratio that urea and formaldehyde mix is 1:1.5～1:2.5, and it is 8～9 that the NaOH solution of use 10% is regulated the pH value; With extremely clarification of magnetic stirrer, under 60～80 ℃ of conditions of temperature, stirring at low speed; Insulation reaction 1～1.5 hour generates the transparent Lauxite of thickness, the deionized water that adding equates with urea and formaldehyde gross weight; Stirring at low speed obtains the transparent urea resin prepolymer aqueous solution.
(2) preparation of Fluoxastrobin mixture solution: will the normal temperature state be powdery or block Fluoxastrobin be dissolved in solvent (the solvent usage amount so that the Fluoxastrobin dissolving or disperse till) in; The emulsifier of adding 1%～10% carries out fully emulsified; Under 30 ℃ temperature, after 1000～1500 rev/mins of rotating speeds stirrings it is fully disperseed.
(3) preparation of Fluoxastrobin microcapsules: the urea resin prepolymer aqueous solution joined at 1000～1500 rev/mins of rotating speeds stir in the above-mentioned Fluoxastrobin mixture solution down, stir 15 minutes stable emulsions of formation, reduce stir speed (S.S.) to 500 rev/min again; Add an amount of acetate slowly, its pH value is transferred to 5, temperature rises to 60～80 ℃; Isothermal reaction is cyst wall curing completion after 2 hours; It is 7 that the NaOH solution of use 10% is regulated the pH value with product, adds an amount of dispersant, antifreezing agent, complements to 100% with deionized water; Sheared 15 minutes with 6000 rev/mins then, promptly obtain the Fluoxastrobin micro-capsule suspension.
In the cyst wall solidify reaction process, whenever at a distance from sampling in 15 minutes 1 time, use the capsule process of each stage of reaction of microscopic examination, use the pH value of pH meter monitoring reaction course.
The present invention compared with prior art, it is few to have an equipment investment, technology is easy to control, stable reaction is suitable for suitability for industrialized production, and has advantages such as sustained release performance.Fluoxastrobin micro-capsule suspension of the present invention has not only solved Fluoxastrobin combines to influence drug effect with soil problem; Reduce consumption through slowly-releasing simultaneously, prolong the drug effect term of validity, consolidate control efficiency; Be difficult for making agricultural chemicals by atmosphere; Sunlight and rainwater destroy and run off, and effectively control reduces the influence to ecotope to phreatic pollution.
Embodiment
Essence is for a better understanding of the present invention explained technology contents of the present invention below in conjunction with specific embodiment, but content of the present invention is not limited thereto.
According to the present invention a kind of preparation method of Fluoxastrobin micro-capsule suspension is provided, can processes the Fluoxastrobin percentage by weight and be 1%～10% micro-capsule suspension.
Embodiment 1:5% Fluoxastrobin micro-capsule suspension.
Urea is dissolved in the formaldehyde, and the weight ratio that urea and formaldehyde mix is 1:2, and it is 8.5 that the NaOH solution of use 10% is regulated the pH value; With extremely clarification of magnetic stirrer, under 70 ℃ of conditions of temperature, stirring at low speed; Insulation reaction 1 hour generates the transparent Lauxite of thickness, the deionized water that adding equates with urea and formaldehyde gross weight; Stirring at low speed obtains the transparent urea resin prepolymer aqueous solution.
At normal temperatures, 5% Fluoxastrobin is dissolved in 15% xylol, adds 2% agricultural newborn 600# and carry out fully emulsifiedly, under 30 ℃ temperature, after stirring with 1000 rev/mins of rotating speeds it is fully disperseed.
An amount of urea resin prepolymer aqueous solution joined at 1000 rev/mins of rotating speeds stir in the above-mentioned Fluoxastrobin mixture solution down, stir 15 minutes stable emulsions of formation, reduce stir speed (S.S.) to 500 rev/min again; To wherein adding 0.5% an amount of acetate slowly, its pH value is transferred to 5, temperature rises to 60 ℃; Isothermal reaction is cyst wall curing completion after 2 hours; It is 7 that the NaOH solution of use 10% is regulated the pH value with product, adds dispersant 2% SOPA-270, antifreezing agent 3% ethylene glycol, complements to 100% with deionized water; Sheared 15 minutes with 6000 rev/mins then, promptly obtain 5% Fluoxastrobin micro-capsule suspension.
Embodiment 2:8% Fluoxastrobin micro-capsule suspension.
Urea is dissolved in the formaldehyde, and the weight ratio that urea and formaldehyde mix is 1:2.5, and it is 8.5 that the NaOH solution of use 10% is regulated the pH value; With extremely clarification of magnetic stirrer, under 70 ℃ of conditions of temperature, stirring at low speed; Insulation reaction 1.5 hours generates the transparent Lauxite of thickness, the deionized water that adding equates with urea and formaldehyde gross weight; Stirring at low speed obtains the transparent urea resin prepolymer aqueous solution.
At normal temperatures, 8% Fluoxastrobin is dissolved in 15% dimethyl formamide, adds 7% Nongru-700 # and carry out fully emulsifiedly, under 30 ℃ temperature, after stirring with 1500 rev/mins of rotating speeds it is fully disperseed.
An amount of urea resin prepolymer aqueous solution joined at 1500 rev/mins of rotating speeds stir in the above-mentioned Fluoxastrobin mixture solution down, stir 15 minutes stable emulsions of formation, reduce stir speed (S.S.) to 500 rev/min again; To wherein adding 0.5% an amount of acetate slowly, its pH value is transferred to 5, temperature rises to 80 ℃; Isothermal reaction is cyst wall curing completion after 2 hours; It is 7 that the NaOH solution of use 10% is regulated the pH value with product, adds 3% dispersant NNO, antifreezing agent 3% glycerine, complements to 100% with deionized water; Sheared 15 minutes with 6000 rev/mins then, promptly obtain 8% Fluoxastrobin micro-capsule suspension.
Fluoxastrobin micro-capsule suspension properties of product of the present invention are stable, are easy to produce store, and are environmentally friendly, safe in utilization.Through evidence, good preventive effect all arranged to powdery mildew of cucumber, cucumber downy mildew, rice blast, wheat glume blight etc. are multiple; Safety is good, and crops are not had poisoning, is a kind of nuisanceless disinfectant use in agriculture that is worthy of popularization.
Claims (2)
1. Fluoxastrobin micro-capsule suspension; It is characterized in that: described Fluoxastrobin micro-capsule suspension is made up of following components in weight percentage: Fluoxastrobin 1%～10%, capsule-core solvent 3%～20%, cyst material 5%～20%, emulsifier 1%～10%; Dispersant 1%～5%; Antifreezing agent 0.5%～7%, pH regulator agent 0.1%～10%, surplus is a deionized water;
Wherein said capsule-core solvent is one or more in dimethyl formamide, ethanol, isopropyl alcohol, n-butanol, hexane, n-octyl alcohol, n-amyl alcohol, acetone, cyclohexanone, xylol, ethyl acetate, N-Methyl pyrrolidone, diethyl phthalate, acetonitrile, carrene, the dibutyl phthalate;
Described cyst material is the urea resin prepolymer aqueous solution, is to be mixed with weight ratio 1:1.5～1:2.5 by urea and formaldehyde, obtains through polycondensation reaction;
Described emulsifier is one or more in agricultural newborn 33#, 34#, 500#, 600#, 700#, NP-10, PNP-10, EL-40,1601#, 2000#, PF-690, BY-130, the tween-120:
Described dispersant is one or more in SOPA-270, dispersant NNO, sodium lignin sulfonate, the dispersant 2700;
Described antifreezing agent is one or more in ethylene glycol, propane diols, glycerine, the diethylene glycol;
Described pH regulator agent is sodium hydroxide or acetate.
2. the preparation method of a Fluoxastrobin micro-capsule suspension is characterized in that:
(1) urea is dissolved in the formaldehyde, the weight ratio that urea and formaldehyde mix is 1:1.5～1:2.5, and it is 8～9 that the NaOH solution of use 10% is regulated the pH value; With extremely clarification of magnetic stirrer, under 60～80 ℃ of conditions of temperature, stirring at low speed; Insulation reaction 1～1.5 hour generates the transparent Lauxite of thickness, the deionized water that adding equates with urea and formaldehyde gross weight; Stirring at low speed obtains the transparent urea resin prepolymer aqueous solution;
(2) preparation of Fluoxastrobin mixture solution: will be powdery or block Fluoxastrobin is dissolved in the solvent at the normal temperature state; The solvent usage amount is so that till Fluoxastrobin dissolving or the dispersion; The emulsifier of adding 1%～10% carries out fully emulsified; Under 30 ℃ temperature, after 1000～1500 rev/mins of rotating speeds stirrings it is fully disperseed;
(3) preparation of Fluoxastrobin microcapsules: the urea resin prepolymer aqueous solution joined at 1000～1500 rev/mins of rotating speeds stir in the above-mentioned Fluoxastrobin mixture solution down, stir 15 minutes stable emulsions of formation, reduce stir speed (S.S.) to 500 rev/min again; Add an amount of acetate slowly, its pH value is transferred to 5, temperature rises to 60～80 ℃; Isothermal reaction is cyst wall curing completion after 2 hours; It is 7 that the NaOH solution of use 10% is regulated the pH value with product, adds an amount of dispersant, antifreezing agent, complements to 100% with deionized water; Sheared 15 minutes with 6000 rev/mins then, promptly obtain the Fluoxastrobin micro-capsule suspension;
In the cyst wall solidify reaction process, whenever at a distance from sampling in 15 minutes 1 time, use the capsule process of each stage of reaction of microscopic examination, use the pH value of pH meter monitoring reaction course.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103783039A (en) * | 2013-12-27 | 2014-05-14 | 中国农业科学院植物保护研究所 | Azoxystrobin nanocapsule with shell-core structure and preparation method thereof |
| CN105076145A (en) * | 2015-08-20 | 2015-11-25 | 广东中迅农科股份有限公司 | Microcapsule suspending agent containing azoxystrobin and preparation method thereof |
| CN106070203A (en) * | 2016-06-03 | 2016-11-09 | 安徽广信农化股份有限公司 | A kind of preparation method of Fluoxastrobin microcapsule |
| CN107318849A (en) * | 2017-08-02 | 2017-11-07 | 天津市农药研究所 | A kind of preparation and its application of 26% Fluoxastrobin cyazofamid micro-capsule suspension |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103783039A (en) * | 2013-12-27 | 2014-05-14 | 中国农业科学院植物保护研究所 | Azoxystrobin nanocapsule with shell-core structure and preparation method thereof |
| CN105076145A (en) * | 2015-08-20 | 2015-11-25 | 广东中迅农科股份有限公司 | Microcapsule suspending agent containing azoxystrobin and preparation method thereof |
| CN106070203A (en) * | 2016-06-03 | 2016-11-09 | 安徽广信农化股份有限公司 | A kind of preparation method of Fluoxastrobin microcapsule |
| CN107318849A (en) * | 2017-08-02 | 2017-11-07 | 天津市农药研究所 | A kind of preparation and its application of 26% Fluoxastrobin cyazofamid micro-capsule suspension |
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