CN106070203A - A kind of preparation method of Fluoxastrobin microcapsule - Google Patents
A kind of preparation method of Fluoxastrobin microcapsule Download PDFInfo
- Publication number
- CN106070203A CN106070203A CN201610412334.9A CN201610412334A CN106070203A CN 106070203 A CN106070203 A CN 106070203A CN 201610412334 A CN201610412334 A CN 201610412334A CN 106070203 A CN106070203 A CN 106070203A
- Authority
- CN
- China
- Prior art keywords
- gelatin
- fluoxastrobin
- weight portion
- distilled water
- microcapsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
The preparation method of a kind of Fluoxastrobin microcapsule, comprises the following steps: weigh gelatin and arabic gum, and after dissolving wiring solution-forming with distilled water, then medicine former with Fluoxastrobin is configured to Emulsion, then adjusts pH with acetic acid, until gelatin produces cohesion, then carries out the cured of microcapsule.The present invention selects Biodegradable material gelatin and arabic gum as the carrier material of Fluoxastrobin, and not only covered effect is good, and its catabolite is also that environment is not resulted in pollution；Under conditions of Isodose, the time using the Fluoxastrobin holding drug effect of microencapsulation is longer.
Description
Technical field
The present invention relates to formulations of pesticide manufacture field, be specifically related to the preparation method of a kind of Fluoxastrobin microcapsule.
Background technology
Fluoxastrobin is a kind of beta-methoxy acrylic ester natural bactericidal agent separated from mushroom, is a kind of global sales
Maximum antibacterial, the sales volume of 2014 breaks through 1,500,000,000 dollars, and demand is with the amplification sustainable growth of about 15%.Phonetic bacterium
The former medicine of ester and complex preparation have crossed patent life the most, and domestic existing a large amount of producers produce.At present, domestic former drug prods about 6000
Ton, wherein 88% exportation abroad.2016, the whole world former drug prods of Fluoxastrobin was expected to break through 10,000 tons, so the synthesis of Fluoxastrobin shows
Obtain particularly important.
Based on to the protection of ecological environment and the raising of human health consciousness, the formulations of pesticide are just towards efficient, low toxicity, low residual
The direction stayed is developed.Under current novel agrochemical compound develops the situation of more difficult, by advanced formulation method
Improve the serviceability of pesticide, give full play to biological activity and the usefulness of effective ingredient, have become as raising pesticide control effect,
Reduce residual contamination, the important channel of saving dispenser cost.And in recent years, the medicine cladding microcapsule with natural polymer as carrier
Chemical conversion is the focus of slow-releasing drug research.It is that microencapsulation pesticide prepared by carrier material has based on Biodegradable high-molecular
Higher drug accumulation burst size, and discharge by the control of medicine carrying material degradation rate being realized the control of medicine,
Thus overcome decomposition that traditional formulations of pesticide exist in use, the prominent serious problems such as release, improve effective utilization of pesticide
Rate, extends the lasting period, decreases the pollution to environment.
Summary of the invention
For problems of the prior art, the present invention provides the preparation method of a kind of Fluoxastrobin microcapsule.
The present invention can be achieved through the following technical solutions:
The preparation method of a kind of Fluoxastrobin microcapsule, comprises the following steps:
(1) weigh gelatin and the arabic gum of 1 weight portion under room temperature respectively, in gelatin, add a small amount of distilled water make it
Soak swelling, be subsequently added into 30 weight portion distilled water, be heated to 60-80 DEG C and make Gelatin complete, standby in 50 DEG C of insulations；Again
After arabic gum is heated to 80 DEG C, it is gently mixed and makes it dissolve, add 30 weight portion distilled water, obtain Arabic peptization
Liquid；
(2) weigh Fluoxastrobin former medicine 0.5 weight portion to be placed in blender with the gumwater in step 1, control to stir
The speed mixed is 60-100r/min, stirs 5min, obtains Emulsion, then mixed with the gelatin solution in step 1 by Emulsion, slowly
After stirring, being placed in the water-bath of 50-55 DEG C, mixing speed is 20-30r/min, and dripping concentration in system is 10%
Acetum carries out the regulation of pH, until pH value is 3.8-4.0, is stirred continuously and makes gelatin produce cohesion；
(3) after gelatin cohesion completely in step 2, it is slowly added to distilled water 80 weight portion of 30-40 DEG C, keeps 20-
The mixing speed of 30r/min is stirred, and after system is uniformly dispersed, closes heating in water bath and carries out natural cooling, treat that temperature is
When 32-35 DEG C, transferring in ice-water bath, stirring makes system temperature be down to less than 10 DEG C, then drips the formaldehyde that concentration is 37%
Solution, continues stirring 20min, then with after the sodium hydroxide solution regulation pH value of solution that concentration is 20% to 8-9, is formed after stirring 1h
Solidification capsule.
The invention have the benefit that 1) present invention selects Biodegradable material gelatin and arabic gum as pyrazoles ether
The carrier material of bacterium ester, not only covered effect is good, and its catabolite is also that environment is not resulted in pollution；2) at Isodose
Under the conditions of, the time using the Fluoxastrobin holding drug effect of microencapsulation is longer.
Detailed description of the invention:
By embodiment, the detailed description of the invention of the present invention is made an explanation below.
Embodiment
The preparation method of a kind of Fluoxastrobin microcapsule, comprises the following steps: weigh the gelatin of 1 weight portion under (1) room temperature respectively
And arabic gum, adding a small amount of distilled water in gelatin, to make it soak swelling, is subsequently added into 30 weight portion distilled water, is heated to
70 DEG C make Gelatin complete, standby in 50 DEG C of insulations；After again arabic gum being heated to 80 DEG C, it is gently mixed and makes it dissolve,
Add 30 weight portion distilled water, obtain gumwater；(2) Fluoxastrobin former medicine 0.5 weight portion and the Ah in step 1 are weighed
Drawing primary sol solution to be placed in blender, the speed controlling stirring is 100r/min, stirs 5min, obtains Emulsion, then by Emulsion with
Gelatin solution mixing in step 1, after being slowly stirred uniformly, is placed in the water-bath of 50 DEG C, and mixing speed is 30r/min, Xiang Ti
Drip the acetum that concentration is 10% in system and carry out the regulation of pH, until pH value is 4.0, is stirred continuously and makes gelatin generation solidifying
Poly-；(3) after gelatin cohesion completely in step 2, it is slowly added to distilled water 80 weight portion of 35 DEG C, keeps the stirring of 25r/min
Speed is stirred, and after system is uniformly dispersed, closes heating in water bath and carries out natural cooling, when temperature is 35 DEG C, retransfer
To ice-water bath, stirring makes system temperature be down to 5 DEG C, then drips the formalin that concentration is 37%, continues stirring 20min, then
After the sodium hydroxide solution regulation pH value of solution that concentration is 20% to 9, after stirring 1h, form solidification capsule.
The present embodiment obtains the envelop rate 95% of Fluoxastrobin microcapsule, dispersibility 90%.With rice blast for preventing and treating
Object, contrasts the Fluoxastrobin of the microencapsulation in embodiment 1 with common Fluoxastrobin, is using the situation that effective dose is identical
Under, compare both prevention effects.Found that: after medicine 20 days, the prevention effect of the Fluoxastrobin microcapsule of the present invention almost without
Reduce, and the drug effect of common Fluoxastrobin near original 1/3rd, the preventive effect of this explanation Fluoxastrobin microcapsule is higher than common
Fluoxastrobin.
The foregoing is only highly preferred embodiment of the present invention, not in order to limit the present invention, all essences in the present invention
Any amendment, equivalent and the improvement etc. made within god and principle, should be included within the scope of the present invention.
Claims (1)
1. the preparation method of a Fluoxastrobin microcapsule, it is characterised in that comprise the following steps:
(1) weigh gelatin and the arabic gum of 1 weight portion under room temperature respectively, in gelatin, add a small amount of distilled water make it soak
Swelling, it is subsequently added into 30 weight portion distilled water, is heated to 60-80 DEG C and makes Gelatin complete, standby in 50 DEG C of insulations；Again by Ah
After drawing primary glue to be heated to 80 DEG C, it is gently mixed and makes it dissolve, add 30 weight portion distilled water, obtain gumwater；
(2) weigh Fluoxastrobin former medicine 0.5 weight portion to be placed in blender with the gumwater in step 1, control stirring
Speed is 60-100r/min, stirs 5min, obtains Emulsion, then mixed with the gelatin solution in step 1 by Emulsion, be slowly stirred
After Jun Yun, being placed in the water-bath of 50-55 DEG C, mixing speed is 20-30r/min, and dripping concentration in system is the acetic acid of 10%
Solution carries out the regulation of pH, until pH value is 3.8-4.0, is stirred continuously and makes gelatin produce cohesion；
(3) after gelatin cohesion completely in step 2, it is slowly added to distilled water 80 weight portion of 30-40 DEG C, keeps 20-30r/min
Mixing speed be stirred, after system is uniformly dispersed, close heating in water bath carry out natural cooling, treat that temperature is 32-35 DEG C
Time, transfer in ice-water bath, stirring makes system temperature be down to less than 10 DEG C, then drips the formalin that concentration is 37%, continues
Continuous stirring 20min, then with after the sodium hydroxide solution regulation pH value of solution that concentration is 20% to 8-9, after stirring 1h, form solidification capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610412334.9A CN106070203A (en) | 2016-06-03 | 2016-06-03 | A kind of preparation method of Fluoxastrobin microcapsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610412334.9A CN106070203A (en) | 2016-06-03 | 2016-06-03 | A kind of preparation method of Fluoxastrobin microcapsule |
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| Publication Number | Publication Date |
|---|---|
| CN106070203A true CN106070203A (en) | 2016-11-09 |
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ID=57845930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610412334.9A Pending CN106070203A (en) | 2016-06-03 | 2016-06-03 | A kind of preparation method of Fluoxastrobin microcapsule |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108849881A (en) * | 2018-06-19 | 2018-11-23 | 江苏邦盛生物科技有限责任公司 | A kind of Fluoxastrobin microcapsule suspending agent and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102599165A (en) * | 2012-02-21 | 2012-07-25 | 广东中迅农科股份有限公司 | Azoxystrobin microcapsule suspending agent and preparation method thereof |
| CN105076145A (en) * | 2015-08-20 | 2015-11-25 | 广东中迅农科股份有限公司 | Microcapsule suspending agent containing azoxystrobin and preparation method thereof |
| CN105284871A (en) * | 2014-07-18 | 2016-02-03 | 青岛瀚生生物科技股份有限公司 | Microcapsule suspending agent compounded by pyraclostrobin and chlorpyrifos and preparation method thereof |
-
2016
- 2016-06-03 CN CN201610412334.9A patent/CN106070203A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102599165A (en) * | 2012-02-21 | 2012-07-25 | 广东中迅农科股份有限公司 | Azoxystrobin microcapsule suspending agent and preparation method thereof |
| CN105284871A (en) * | 2014-07-18 | 2016-02-03 | 青岛瀚生生物科技股份有限公司 | Microcapsule suspending agent compounded by pyraclostrobin and chlorpyrifos and preparation method thereof |
| CN105076145A (en) * | 2015-08-20 | 2015-11-25 | 广东中迅农科股份有限公司 | Microcapsule suspending agent containing azoxystrobin and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《安徽农业科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108849881A (en) * | 2018-06-19 | 2018-11-23 | 江苏邦盛生物科技有限责任公司 | A kind of Fluoxastrobin microcapsule suspending agent and preparation method thereof |
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Application publication date: 20161109 |