CN102210301B - Sustained control release preparation of nano porous active carbon-carrying agricultural antibiotic and preparation method thereof - Google Patents
Sustained control release preparation of nano porous active carbon-carrying agricultural antibiotic and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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Abstract
The invention discloses a sustained control release preparation of a nano porous active carbon-carrying agricultural antibiotic and a preparation method thereof. The sustained control release preparation consists of the following components in percentage by weight: 15 to 40 percent of nano porous carbon, 50 to 80 percent of agricultural antibiotic, 0.25 to 1.0 percent of emulsifying agent, 0.5 to 1.0 percent of thickening agent, 0.25 to 1.0 percent of dispersing agent, 0.25 to 1.0 percent of quickly penetrating agent and the balance of filler. The preparation method comprises the following steps of: after the agricultural antibiotic is dissolved, absorbing the agricultural antibiotic by using the nano porous active carbon; recrystallizing; adding the components according to the ratio; mixing completely and uniformly; and grinding and crushing the mixture to obtain the sustained control release preparation. The sustained control release preparation can effectively avoid illumination and degradation of microorganisms and can greatly increase the utilization ratio of the agricultural antibiotic.
Description
Technical field
The present invention relates to the Pesticide formulation field, say further, relate to a kind of sustained-release preparation and preparation method of nano porous active carbon-carrying farm antibiotics.
Background technology
China is a large agricultural country, and agricultural chemicals is the essential thing in the agricultural production, is widely used in crop disease control, for improving crop yield, keeps social stability, and it is significant to promote economic development.The chemical pesticide no doubt lethality to insect is very large, but has has meanwhile also killed and wounded the natural enemy biology, has destroyed the ecological balance, causes insect regeneration rampant, makes minor pests rise to primary pest.In addition, because long-term a large amount of use of chemical pesticide, so that the pesticide resistance of insect significantly improves, pesticide residue in agricultural products increases simultaneously, causes serious environment pollution, jeopardizes human health and life.
Farm antibiotics is to grow up gradually on the basis of the medical antibiotic research forties in 20th century, one class is produced by microbial fermentation, have the agricultural chemicals function, be used for the control agricultural pest, or the microbial secondary metabolite of regulating crop growth growth.Compare with chemical pesticide, farm antibiotics has that raw materials for production are extensive, selectivity is strong, pollution-free, be difficult for developing immunity to drugs and do not destroy the characteristics such as ecotope, therefore have broad application prospects.
At present, the research of farm antibiotics is in the ascendant, and the states such as the U.S., Russia, Japan and West Europe all classify the research of farm antibiotics as the state key scientific research planning.Farm antibiotics mostly is fat-soluble organic macromolecule simultaneously, and is water-soluble relatively poor, needs to add a large amount of toluene, acetone and other organic solvent in the production and application process, may cause certain environmental pollution; Also be subject to easily simultaneously illumination and microbial action and degrade and lose activity, existence and stability is relatively poor, and condition of storage is harsh, the defective that control efficiency is undesirable.
Nanometer technology is a kind of emerging technology of being born in the eighties in 20th century and developing rapidly, and it has been penetrated into the every field such as life science, medicine, material, chemical industry, agricultural, brings positive far-reaching influence for human life.As an emerging subject, since the nineties in last century, China has dropped into a large amount of manpower and materials in the nanometer field, in succession implemented " nano science route card " and " national Development of Nano-technology outline (2001～2010) ", obtain great achievement in the function nano investigation of materials, caused international concern.Nano material is the material that has at least one dimension to be in the nanoscale scope or to be made of as elementary cell them in the three dimensions.Nano-porous materials has the characteristics such as specific surface area is large, pore-size distribution is narrow, pore passage structure is regular, becomes gradually in recent years study hotspot.The characteristics such as nano-porous materials is a kind of sorbing material that enriches pore structure and huge specific surface area that has, and it has high adsorption capacity, and chemical stability is good are widely used in the fields such as industry, agricultural, national defence, traffic, medical and health, environmental protection.Nanometer technology has obtained great successes at field of medicaments, yet compare with pharmaceutical preparation, nanometer technology is used in the research of the formulations of pesticide, then seem and relatively lag behind, although the formulations of pesticide and pharmaceutical dosage form are made a world of difference at manufacturing process, using method and application target, but all refer in essence have the pharmaceutical dispersions form of various specific physical and chemical performances, such as pulvis, granula, effervescent agent, microemulsion, suspending agent etc.Therefore, nanometer technology obtained achievement in pharmaceutical preparation also can obtain using for reference and development at pesticide field.Although the application of nanometer technology on agricultural can not show a candle to the progress in fields such as medicine, material and industry, but nanometer technology provides advanced thinking and means for the research of pesticides new formulation, overcome the deficiency of conventional dosage forms, make the formulations of pesticide more and more near the needs of agricultural sustainable development.
Pesticide pollution has become one of significant problem that hinders agricultural sustainable development, and Development of Novel high-efficiency agriculture farm antibiotics is the great demand of China's Sustainable Development of Modern Agriculture and ecological environmental protection.The application of nanosecond science and technology in agriculture field will be opened the New Times of agriculture field research.
Therefore, develop the slow controlled release farm antibiotics preparation that a kind of nano-porous materials supports, can effectively reduce organic solvent and use, the control rate of release, prolong action time, avoid degraded in use, the Effective Raise availability is one of farm antibiotics future development important directions.
At present, sustained-release preparation about farm antibiotics, the paper of bibliographical information has: surface modification of silica and to Avermectin absorption and sustained release performance (Lin Chunmei etc.), nanometer SiO2 surface modification and on the impact (Liu Qi) of Avermectin absorption property, the performance study (Sun Changjiao) of mesoporous activated carbon Avermectin drug-loading system and the preparation and property of Novel Abamectin nano controlled release agent research (Li Zhuzhu), that has applied for patent of invention has a nano-microcapsule suspending agent (Chinese patent: X03121410), a kind of agriculturally useful compositions and preparation method thereof (Chinese patent application number: 200410043313.1), long-acting slow-releasing and controlled-releasing wetting powder (Chinese patent application number: 200510125988.5), long-acting slow-release oil suspending agent (Chinese patent application number: 200510125989.X) and have an avermectin nanometer medicine-carried system (Chinese patent application number 200710165258.7) of slow-releasing and controlled-releasing action.More than each patent all exist load capacity low, the problem that slow-release time is short.
Patent of invention for the water-soluble farm antibiotics with slow releasing function of porous activated carbon research and development there is not yet report at home and abroad.
Summary of the invention
For solving the farm antibiotics less stable that exists in the prior art, condition of storage is harsh, the problems such as control efficiency is undesirable, the invention provides a kind of sustained-release preparation and preparation method of nano porous active carbon-carrying farm antibiotics, can effectively avoid the degradation of illumination and microorganism, greatly improve the availability of farm antibiotics.
One of purpose of the present invention provides a kind of sustained-release preparation of nano porous active carbon-carrying farm antibiotics.
Composed of the following components:
Nano porous active carbon 15～40wt%,
Emulsifier 0.25～1.0wt%,
Thickener 0.5～1.0wt%,
Dispersant 0.25～1.0wt%,
Bleeding agent 0.25～1.0wt%,
All the other are filler, and each weight percentages of components sum is 100%,
Wherein said nano porous active carbon be the aperture at the cellular solid of 100nm～500nm, have the characteristics such as specific surface area is large, pore-size distribution is narrow, pore passage structure is regular;
Described farm antibiotics is the antibiotic that usually adopts in this area, preferred jinggangmeisu, Wuyiencin, pleocidin, methyl Avermectin, pyrethrin, one or more in the Avermectin;
Described emulsifier, thickener, dispersant, bleeding agent and additive are the material that usually adopts in this area, all are suitable for the present invention, and be concrete:
Emulsifier is neopelex, styryl phenol formaldehyde resin, Tween-80, polyoxyethylene polyoxypropylene block type polyethers, polyoxyethylene alkylphenol ether, OPEO, polyoxyethylene nonylphenol ether, aliphatic alcohol polyethenoxy, sulfonic acid esters preferably, amide-type, in silicone based one or more, more preferably neopelex and/or polyoxyethylene alkylphenol ether;
But the thickener preferred starch, methylcellulose, carboxymethyl cellulose, ethyl cellulose, cyclodextrin, polymethyl methacrylate, microcrystalline cellulose, sodium alginate, Sodium Polyacrylate, poly lactic-co-glycolic acid, PLA, pectin, agar, gelatin, gum Arabic, polysaccharide derivates, polyethylene glycol oxide, polyvinylpyrrolidone, polyvinyl alcohol, in the polyvinyl lactam one or more, more preferably one or more in starch, cyclodextrin, microcrystalline cellulose, sodium alginate, pectin, the gelatin;
Dispersant preferably in modified sodium lignosulfonate salt, MODIFIED LIGNOSULPHONATE salt, dimethyl sebacate, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate, borate, the sodium polyphosphate one or more, more preferably modified sodium lignosulfonate salt and/or MODIFIED LIGNOSULPHONATE salt;
Bleeding agent is one or more in aerosol-OT salt, alkylphenol polyoxyethylene, the dimethyl sulfoxide (DMSO) preferably;
Filler is urea and/or sodium bicarbonate.
Described preparation is tablet, granula, pulvis or aqueous suspension agent.
Two of purpose of the present invention provides a kind of preparation method of sustained-release preparation of nanoporous activated carbon loaded farm antibiotics.
Comprise following steps:
After the farm antibiotics dissolving, fully adsorb farm antibiotics with nano porous active carbon, then recrystallization adds described component in described ratio, and fully mixed grinding after evenly makes pulvis;
Perhaps described pulvis is made tablet or granula after compressing tablet or granulation;
Perhaps described pulvis is made aqueous suspension agent behind emulsification pretreatment.
Concrete operations are as follows:
After first farm antibiotics fully being dissolved, fully adsorb farm antibiotics with nano porous active carbon, process through recrystallization, obtain the slow controlled release granule of farm antibiotics-active carbon.Then add in proportion other various components, fully grind behind the mixing, can obtain pulvis.Take out pulvis, place tablet press machine or comminutor, by certain specification, be pressed into sheet or granular, can obtain tablet or the granula of nano porous active carbon load farm antibiotics; Pulvis is placed the high-speed shearing emulsion machine emulsification pretreatment, namely obtain the aqueous suspension agent of nano porous active carbon-carrying farm antibiotics after homogenizing.
By utilizing the adsorptivity of nano porous active carbon, the farm antibiotics sustained-release preparation of preparation nano porous active carbon load can effectively improve the solubility property of farm antibiotics on the one hand, reduce organic solvent use and to the pollution of ecotope; Simultaneously, because farm antibiotics enters in the porous material space, can effectively avoid the degradation of illumination and microorganism, greatly improve the availability of farm antibiotics.
Recrystallization is a kind of basic chemical operation method, and recrystallization (recrystallization) is after crystal is dissolved in solvent or melting, again the process of crystallization from solution or melt.Claim again recrystallization.Recrystallization can make unpurified material obtain purifying, or makes the salt that mixes separated from one another.The present invention is (this moment, most of farm antibiotics still was dissolved in the solvent) after fully adsorbing farm antibiotics with nano porous active carbon, introduce the recrystallization operation, by vacuum evaporation, with the solvent slow evaporation in the solvent, make farm antibiotics slowly crystallization in the hole of nano porous active carbon.The present invention is by utilizing recrystallization technology, significantly improved porous activated carbon to the availability of the medicine carrying amount of Avermectin, pyrethrins, jinggangmeisu and Wuyiencin, sustained release performance, farm antibiotics, effectively reduces the pollution to environment.And what the present invention adopted is the porous activated carbon of 100nm-500nm, and its specific surface area is larger, and load effect is better.
Description of drawings
The slow controlled release properties resolution chart of the Avermectin tablet of Fig. 1 embodiment 1 preparation
The slow controlled release properties end view of the Avermectin particle of Fig. 2 Comparative Examples 1 preparation
Embodiment
Below in conjunction with embodiment, further specify the present invention.
Raw materials used source is as follows among the embodiment:
This example is the preparation that the preparation nano porous active carbon-carrying contains 50% Avermectin
The former medicine 1.0kg of Avermectin is joined in the blending tank, add 100L acetone, fully add 0.8kg porous activated carbon [aperture is between 100nm-500nm] after the dissolving, fully adsorb to shift behind the 24h and put in the Rotary Evaporators.50 ℃, under the 0.02MPa, evaporation acetone makes the abamectin solution recrystallization.After recrystallization finishes, obtain the slow controlled release granule of Avermectin-active carbon.Then add the 0.01kg microcrystalline cellulose, 0.01kg sodium alginate, 0.02kg neopelex, 0.01kg sodium polyphosphate, 0.01kg dimethyl sulfoxide (DMSO), 0.01kg aerosol-OT salt, 0.13kg urea after mixing, places grinding in ball grinder 3h, mixture is taken out, can obtain the pulvis that nano porous active carbon-carrying contains 50% Avermectin.Take out pulvis, place tablet press machine or comminutor, by certain specification, be pressed into sheet or granular, can obtain tablet or granula that nano porous active carbon-carrying contains 50% Avermectin; Pulvis is placed the high-speed shearing emulsion machine emulsification pretreatment, namely obtain the aqueous suspension agent that nano porous active carbon-carrying contains 50% Avermectin after homogenizing.
Comparative example 1
Accurately the Avermectin ethanol stock solution of preparation 10mg/mL is preserved under 4 ℃ of lucifuge conditions.Get the 100mL band plug triangular flask of 10 dryings, add respectively 50mL Avermectin storing solution, 0.5g mesoporous activated carbon [aperture is between 5nm-50nm], mixing is placed on the constant temperature oscillator, adsorbs 48h under 100r/min, 30 ℃ of conditions, obtains the slow controlled release granule of Avermectin.The medicine carrying amount is 22.06%.
Comparative example 2
According to Chinese patent (application number: 200710165258.7) described method preparation:
Take by weighing Avermectin 120.0g, 80g has the nano silicon of loose structure, by forming avermectin nanometer medicine-carried particle after the physical adsorption.Avermectin nanometer medicine-carried particle (the effective load-carry duty 60% of Avermectin), sodium lignin sulfonate 100.0g with 20.0g, naphthalenesulfonate formaldehyde condensation compound 20.0g, polymethylacrylic acid carboxylate graft copolymer 20.0g, sodium carboxymethylcellulose 5.0g, ammonium sulfate 150.0g, supply 1000g with diatomite, under agravic condition, mixed 10 minutes, pulverize; Namely get 20% avermectin nanometer medicine-carried system.
Comparative example 3
According to Chinese patent (application number: 200710165258.7) described method preparation
Get avermectin nanometer medicine-carried particle (the effective load-carry duty 60% of Avermectin), the sodium lignin sulfonate 100.0g of 3.5g, naphthalenesulfonate formaldehyde condensation compound 20.0g, soluble starch 5.0g, ammonium sulfate 90.0g, with the black 1000g that supplies on daytime, under agravic condition, mixed 10 minutes, pulverize; Namely get 3.5% avermectin nanometer medicine-carried system.
Data by embodiment 1 and Comparative Examples can be found out, by adopting the aperture at nano porous active carbon and the recrystallization technology of 100nm-500nm, have significantly improved the medicine carrying amount of Avermectin controlled release agent by the present invention.
This experiment is that the preparation porous activated carbon supports the preparation that contains 60% pyrethrins
The former medicine 1.2kg of pyrethrins is joined in the blending tank, add 100L acetone, fully add 0.6kg nano porous active carbon [aperture is between 100nm-500nm] after the dissolving, fully adsorb to shift behind the 24h and put in the Rotary Evaporators.50 ℃, under the 0.02MPa, evaporation acetone makes the abamectin solution recrystallization.After recrystallization finishes, obtain the slow controlled release granule of pyrethrins-active carbon.And then adding 0.01kg microcrystalline cellulose, 0.01kg sodium alginate, 0.02kg neopelex, 0.01kg sodium polyphosphate, 0.01kg dimethyl sulfoxide (DMSO), 0.01kg aerosol-OT salt, 0.13kg urea after mixing, places grinding in ball grinder 3h, mixture is taken out, can obtain the pulvis that nano porous active carbon-carrying contains 60% pyrethrins.Take out pulvis, place tablet press machine or comminutor, by certain specification, be pressed into sheet or granular, can obtain tablet or granula that nano porous active carbon-carrying contains 60% pyrethrins; Pulvis is placed the high-speed shearing emulsion machine emulsification pretreatment, namely obtain the aqueous suspension agent that nano porous active carbon-carrying contains 60% pyrethrins after homogenizing.
This example is that preparation porous nano porous activated carbon supports the preparation that contains 80% jinggangmeisu
Jinggangmeisu 1.6kg is dissolved in the 5L water, adds 0.3kg nano porous active carbon [aperture is between 100nm-500nm] after fully adding fully dissolving after the dissolving, fully adsorb to shift behind the 24h and put in the Rotary Evaporators.50 ℃, under the 0.02MPa, evaporation acetone makes the abamectin solution recrystallization.After recrystallization finishes, obtain the slow controlled release granule of jinggangmeisu-active carbon.And then adding 0.005kg starch, 0.005kg sodium alginate, 0.005kg neopelex, 0.005kg sodium polyphosphate, 0.005kg dimethyl sulfoxide (DMSO), 0.005kg aerosol-OT salt, 0.07kg urea after mixing, places grinding in ball grinder 3h, mixture is taken out, can obtain the pulvis that nano porous active carbon-carrying contains 80% jinggangmeisu.Take out pulvis, place tablet press machine or comminutor, by certain specification, be pressed into sheet or granular, can obtain tablet or granula that nano porous active carbon-carrying contains 80% jinggangmeisu.
This example is that preparation porous nano porous activated carbon supports the preparation that contains 75% Wuyiencin
Wuyiencin 1.5kg is dissolved in the 5L water, fully adds 0.3kg nano porous active carbon [aperture is between 100nm-500nm] after the dissolving, fully adsorb to shift behind the 24h and put in the Rotary Evaporators.50 ℃, under the 0.02MPa, evaporation acetone makes the abamectin solution recrystallization.After recrystallization finishes, obtain the slow controlled release granule of Wuyiencin-active carbon.And then adding 0.005kg cyclodextrin; 0.005kg sodium alginate; 0.005kg neopelex; 0.005kg polyoxyethylene alkylphenol ether; 0.005kg sodium polyphosphate, 0.005kg MODIFIED LIGNOSULPHONATE salt, 0.005kg dimethyl sulfoxide (DMSO); 0.165kg urea; after mixing, place grinding in ball grinder 3h, mixture is taken out; can obtain the pulvis that nano porous active carbon-carrying contains 75% Wuyiencin; take out pulvis, place tablet press machine or comminutor, by certain specification; be pressed into sheet or granular, can obtain tablet or granula that nano porous active carbon-carrying contains 75% Wuyiencin.
The sustained release performance test
A: take by weighing the nano porous active carbon-carrying 50% Avermectin preparation tablet of 14g embodiment 1 preparation, be dissolved in the 100ml absolute ethyl alcohol, every other day get supernatant and measure once.Test result as shown in Figure 1.
As seen from Figure 1, in 9 days, the linear stripping of Avermectin, dissolution rate is 83.4%; After 10 days, dissolution rate begins to descend, and reaches dissolution equilibrium after 13 days.
The mesoporous activated carbon that takes by weighing 1 preparation of 14g Comparative Examples supports 22.4% Avermectin particle, is dissolved in the 100ml absolute ethyl alcohol, every other day gets supernatant and measures once.Test result as shown in Figure 2.
As can be seen from Figure 2: within 4 days, the drug-loading system rate of releasing drug is relatively very fast; After 5 days, curve is comparatively mild, reaches dissolution equilibrium.
This shows that the present invention adopts porous activated carbon and recrystallization technology, significantly improved the sustained release performance of nano porous active carbon-Avermectin controlled release agent.
B: take by weighing the nano porous active carbon-carrying 50% Avermectin tablet of 7g embodiment 1 preparation, be dissolved in the 1L water, every other day measure Avermectin content (unit: gram) in preparation.(1. represent aqueous dispersions in the colourless transparent glass bottle, 2. represent aqueous dispersions and be contained in the Brown Glass Brown glass bottles and jars only) Avermectin rate of decay is measured, and test result is as shown in table 1.
The nano silicon that takes by weighing 2 preparations of 100g Comparative Examples supports 3.5% Avermectin particle, be dissolved in the 1L water, measure every other day that Avermectin content (1. represents aqueous dispersions in the colourless transparent glass bottle in preparation, 2. representing aqueous dispersions is contained in the Brown Glass Brown glass bottles and jars only) Avermectin rate of decay mensuration, test result sees Table 2.
Can find out that from the Data Comparison of table 1 and table 2 the present invention has significantly improved the sustained release performance of Avermectin controlled release agent by adopting porous activated carbon and recrystallization technology.
Claims (7)
1. the sustained-release preparation of a nano porous active carbon-carrying farm antibiotics, composed of the following components:
All the other are filler, and each weight percentages of components sum is 100%,
Described nano porous active carbon pore diameter range is between 100nm～500nm.
2. the sustained-release preparation of nano porous active carbon-carrying farm antibiotics as claimed in claim 1 is characterized in that:
Described farm antibiotics is selected from one or more in jinggangmeisu, Wuyiencin, pleocidin, methyl Avermectin, pyrethrins, the Avermectin;
Described emulsifier is selected from neopelex, styryl phenol formaldehyde resin, Tween-80, polyoxyethylene polyoxypropylene block type polyethers, polyoxyethylene alkylphenol ether, OPEO, polyoxyethylene nonylphenol ether, aliphatic alcohol polyethenoxy, sulfonic acid esters, amide-type, one or more in silicone based;
Described thickener is selected from starch, methylcellulose, carboxymethyl cellulose, ethyl cellulose, cyclodextrin, one or more in polymethyl methacrylate, microcrystalline cellulose, sodium alginate, Sodium Polyacrylate, poly lactic-co-glycolic acid, PLA, pectin, agar, gelatin, gum Arabic, polysaccharide derivates, polyethylene glycol oxide, polyvinylpyrrolidone, polyvinyl alcohol, the polyvinyl lactam;
Described dispersant is to be selected from modified sodium lignosulfonate salt, MODIFIED LIGNOSULPHONATE salt, dimethyl sebacate, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate, borate, one or more in the sodium polyphosphate;
Described bleeding agent is one or more in aerosol-OT salt, alkylphenol polyoxyethylene, the dimethyl sulfoxide (DMSO);
Described filler is urea and/or sodium bicarbonate.
3. the sustained-release preparation of nano porous active carbon-carrying farm antibiotics as claimed in claim 2 is characterized in that:
Described emulsifier is neopelex and/or polyoxyethylene alkylphenol ether.
4. the sustained-release preparation of nano porous active carbon-carrying farm antibiotics as claimed in claim 2 is characterized in that:
Described thickener is selected from one or more in starch, cyclodextrin, microcrystalline cellulose, sodium alginate, pectin, the gelatin.
5. the sustained-release preparation of nano porous active carbon-carrying farm antibiotics as claimed in claim 2 is characterized in that:
Described dispersant is modified sodium lignosulfonate salt and/or MODIFIED LIGNOSULPHONATE salt.
6. such as the sustained-release preparation of the described nano porous active carbon-carrying farm antibiotics of one of claim 1～5, it is characterized in that:
Described preparation is tablet, granula or pulvis.
7. such as the preparation method of the sustained-release preparation of the described a kind of nano porous active carbon-carrying farm antibiotics of one of claim 1～6, comprise following steps:
After the farm antibiotics dissolving, fully adsorb with nano porous active carbon, then recrystallization adds described component in described ratio, grind the pulvis that makes described sustained-release preparation after fully mixing evenly, perhaps described pulvis is made tablet or granula after compressing tablet or granulation.
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