CN108992568A - A kind of Chinese medicine for treating lung cancer - Google Patents
A kind of Chinese medicine for treating lung cancer Download PDFInfo
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- CN108992568A CN108992568A CN201811248141.XA CN201811248141A CN108992568A CN 108992568 A CN108992568 A CN 108992568A CN 201811248141 A CN201811248141 A CN 201811248141A CN 108992568 A CN108992568 A CN 108992568A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to the Chinese medicines for the treatment of lung cancer, it is ineffective clinical treatment lung cancer can effectively to be solved, life cycle is short, the high problem of the death rate, by poidometer: Radix Ophiopogonis 12-15 part, 9-12 parts of beggar-ticks, 3-6 parts of spina gleditsiae, 3-6 parts and Ramulus euonymi 6-9 parts of bush are made, by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of bulking values are added, 85% ethyl alcohol of mass concentration impregnates 7 days, it is primary every 12h concussion, each 5-10min is mixed, filtering, it is condensed into the concentrated medicament of 50 DEG C of relative density 1.2-1.4, concentrated medicament is dried in vacuo, it was ground into the fine powder that 120 mesh or more sieve, as finished product.Abundant raw material of the present invention, prescription is scientific and reasonable, at low cost, curative for effect, and effect is good, and pure Chinese medicinal preparation takes safe and convenient, meets traditional Chinese medicine prescription theory, is the innovation treated on lung-cancer medicament, there is huge economic and social benefit.
Description
Technical field
The present invention relates to field of medicaments, especially a kind of Chinese medicine for treating lung cancer.
Background technique
Lung cancer is one of most common malignant tumour in the whole world, in China, as commercial speeds are accelerated, environmental pollution adds
The cancer burden of weight, aging of population aggravation, lung cancer increasingly aggravates.Currently, the control of lung cancer has become whole world extensive concern
The problem of.In China, first of all cancers, annual new cases are 65.10 ten thousand people for lung cancer morbidity rate and the death rate.It treats more
It is to use operation, Radiotherapy chemotherapy, or Chinese medicine is used alone, play synergy, attenuation, improve life quality, extend life cycle etc..Into
Chemicals are carcinogenic, inhibit growth of tumour cell, promote apoptosis of tumor cells, mention the study found that part Chinese medicine can be prevented and treated for one step
High immunity of organisms etc..According to lung cancer clinical performance when belonging to the scopes such as traditional Chinese medicine " lung product " " breath is beautifully adorned ", traditional Chinese medicine treatment to be distinguished
Card treatment, lacks the new Chinese medicine for being exclusively used in treatment lung cancer, and therefore, booster injection develops the traditional Chinese medicine research of lung cancer, and raising is faced
Bed prevention and treatment is horizontal and ability, extension life span reduce the patients with lung cancer death rate and be of great significance.
Summary of the invention
For above situation, for the defect for overcoming existing drug, the purpose of the present invention is just to provide a kind of lung cancer for the treatment of
Chinese medicine, can effectively solve that clinical treatment lung cancer is ineffective, and life cycle is short, the high problem of the death rate.
The technical solution that the present invention solves is: a kind of Chinese medicine for treating lung cancer, the Chinese medicine is by poidometer: Radix Ophiopogonis 12-15
Part, 9-12 parts of beggar-ticks, 3-6 parts of spina gleditsiae, 3-6 parts of bush and 6-9 parts of Ramulus euonymi are made, by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush,
10 times of bulking values, the immersion of 85% ethyl alcohol of mass concentration 7 days is added in Ramulus euonymi, and primary every 12h concussion, each 5-10min is mixed
Even, filtering is condensed into the concentrated medicament of 50 DEG C of relative density 1.2-1.4, concentrated medicament is dried in vacuo, was ground into 120 mesh
The fine powder sieved above, as finished product.
The bulking value refers to solid in terms of g, and liquid is in terms of mL.
Abundant raw material of the present invention, prescription is scientific and reasonable, at low cost, curative for effect, and effect is good, pure Chinese medicinal preparation, takes peace
It is complete convenient, meet traditional Chinese medicine prescription theory, is the innovation treated on lung-cancer medicament, there is huge economic and social benefit.
Detailed description of the invention
Fig. 1 is inhibiting effect dose-effect relationship (%) figure that Chinese medicine of the present invention grows lung cancer A549 cell.
Specific embodiment
It elaborates below in conjunction with concrete condition and embodiment to a specific embodiment of the invention.
Embodiment 1
In specific implementation, a kind of Chinese medicine for treating lung cancer, the Chinese medicine is by poidometer by the present invention: 12 parts of Radix Ophiopogonis, beggar-ticks 9
Part, 3 parts of spina gleditsiae, 3 parts of bush and 6 parts of Ramulus euonymi are made, and by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of weight are added
Volume, 85% ethyl alcohol of mass concentration impregnate 7 days, and primary every 12h concussion, each 5min is mixed, and filtering is dense with Rotary Evaporators
The concentrated medicament for shortening 50 DEG C of relative density 1.2-1.4 into, concentrated medicament is put into vacuum oven and was dried, crushed into 120
The fine powder more than mesh sieved, as finished product.
Embodiment 2
In specific implementation, a kind of Chinese medicine for treating lung cancer, the Chinese medicine is by poidometer by the present invention: 13 parts of Radix Ophiopogonis, beggar-ticks 10
Part, 4 parts of spina gleditsiae, 4 parts of bush, 7 parts of Ramulus euonymi be made, by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of weight are added
Volume, 85% ethyl alcohol of mass concentration impregnate 7 days, and primary every 12h concussion, each 7min is mixed, and filtering is dense with Rotary Evaporators
The concentrated medicament for shortening 50 DEG C of relative density 1.2-1.4 into, concentrated medicament is put into vacuum oven and was dried, crushed into 120
The fine powder more than mesh sieved, as finished product.
Embodiment 3
In specific implementation, a kind of Chinese medicine for treating lung cancer, the Chinese medicine is by poidometer by the present invention: 14 parts of Radix Ophiopogonis, beggar-ticks 11
Part, 5 parts of spina gleditsiae, 5 parts of bush, 8 parts of Ramulus euonymi be made, by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of weight are added
Volume, 85% ethyl alcohol of mass concentration impregnate 7 days, and primary every 12h concussion, each 8min is mixed, and filtering is dense with Rotary Evaporators
The concentrated medicament for shortening 50 DEG C of relative density 1.2-1.4 into, concentrated medicament is put into vacuum oven and was dried, crushed into 120
The fine powder more than mesh sieved, as finished product.
Embodiment 4
In specific implementation, a kind of Chinese medicine for treating lung cancer, the Chinese medicine is by poidometer by the present invention: 15 parts of Radix Ophiopogonis, beggar-ticks 12
Part, 6 parts of spina gleditsiae, 6 parts of bush, 9 parts of Ramulus euonymi be made, by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of weight are added
Volume, 85% ethyl alcohol of mass concentration impregnate 7 days, and primary every 12h concussion, each 9min is mixed, and filtering is dense with Rotary Evaporators
The concentrated medicament for shortening 50 DEG C of relative density 1.2-1.4 into, concentrated medicament is put into vacuum oven and was dried, crushed into 120
The fine powder more than mesh sieved, as finished product.
Chinese medicine thinks that " void, the stasis of blood, poison " is the important pathogenesis of tumor development, and knot is that lung cancer is normal in asthenia of pulmonosplenic qi, ecchymosis
See disease.Lung cancer is a systemic disease, and tumour is the topical manifestations of systemic disease.Whole body belongs to empty, and part is true.
" empty, poison, the stasis of blood " runs through lung cancer each period, and morbidity is that healthy tendency is first empty, and cult poison is taken advantage of a weak point interference, and lungs lose normal physiological
Function, lung qi Fen is strongly fragrant, a surname's drop mistake department, functional activity of QI being not smooth, and the blood stasis by the stagnation of the circulation of vital energy blocks channels, and the defeated cloth of body fluid is unfavorable, and harmony becomes phlegm,
Phlegm wet and ecchymosis, which are handed over, to be hindered, with the passing of time formation lung cancer, this is the sthenia symptoms caused by asthenia because void is fallen ill；Void is disease sheet, actually the mark of disease；Void is
It is systemic, actually locality.It " is treatinged deficiency with tonification, attack it actually " principle according to Chinese medicine, it is lung cancer that poison is attacked in QI invigorating righting, dissipating bind
Main therapeutic rule.Then around the therapy, according to traditional Chinese medical theory, drug screening and prescription have been carried out.
The present invention links closely the interpretation of the cause, onset and process of an illness of lung cancer, dissipates the stasis of blood with heat clearing and blood circulation promoting to treat big method, Radix Ophiopogonis is sweet in flavor in Chinese medicine compound prescription, micro-
Hardship, it is slightly cold, there is the effect of nourishing Yin and promoting production of body fluid, moistening lung to arrest cough.Radix Ophiopogonis is classified as the top grade of Yin nourishing and lung moistening, Yan Qi by Shennong's Herbal
" long term usage is made light of one's life by commiting suicide, not old not hungry "；" herbal lease making " claim Radix Ophiopogonis " sweet, slight bitter, it is slightly cold, have moistening lung and clearing away the heart-fire, purge heat promote the production of body fluid, resolving sputum
Preventing or arresting vomiting controls row water of coughing ".Beggar-ticks is that folks of china often uses herbal medicine, and warm-natured, bitter is nontoxic, has clearing heat and detoxicating, eliminating stasis to subdue swelling
The effect of." Fujian traditional herbal medicine ": blood-stasis-dissipating blood-circulation-promoting, the carbuncle that disappears removing toxic substances；" Quanzhou book on Chinese herbal medicine ": metal-inflicted wound is held back in dispersing blood stasis, analgesia.Spina gleditsiae acrid flavour,
It is warm-natured, there is the effect of detumescence toxin expelling, apocenosis, desinsection, " the high original of book on Chinese herbal medicine " claims it: dispelling pathogenic wind and eliminating phlegm, Toxin-Vanquishing attack poison.Bush is mild-natured,
It is sweet in flavor, salty, promoting circulation of blood dissolving stasis, swelling and pain relieving, " book on Chinese herbal medicine ask former ": " control all waist abdomen hypochondriac pains, numbness pain, turgor vomiting due to sepsis
Person treats puerperal hematoma bruise, and postpartum asthma face is black to be intended to dead, consumptive disease blood Bleach." " medicine justice is shrewd ": " all sluggish blood for staying knot of dispelling."
Ramulus euonymi is bitter；It is pungent；It is cold, there is promoting blood circulation blood promoting menstruation, the efficacy of removing toxicity for detumescence effect, above five medicine is harmonious, and gathers moistening lung to arrest cough, heat-clearing solution altogether
Malicious, activating microcirculation and removing stasis medicinal and tumor suppression growth function.
Chinese medicine compound prescription of the present invention is to treat lung cancer Empirical formula and laboratory at all times arranging and screening based on the lung cancer carcinoma interpretation of the cause, onset and process of an illness
It is researched and developed on Research foundation, has the function of moistening lung to arrest cough, clearing heat and detoxicating, activating microcirculation and removing stasis medicinal and tumor suppression growth.The major functions: lung cancer,
Chinese medical discrimination is the stasis of blood, poison card etc., and Chinese medicine compound prescription experiment in vitro of the present invention has good effect of anti-lung cancer, and small toxicity, related
Data is as follows:
One, anti-lung cancer Chinese medicine inhibits tumour growth experiment
1. material
1.1 drug
Herbal mixture of the present invention.
Cell strain: human lung carcinoma cell line A549 cell is purchased from Chinese Academy of Sciences Shanghai cell bank.
Main agents: RPMI1640 culture medium, fetal calf serum (gemini, lot number A80E00G), MTT(solarbio, batch
Number: 6041051), and DMSO(Amresco, lot number: 302A0334), trypsase-EDTA digestive juice (solarbio, lot number:
20160713).
Key instrument equipment: Heraeus cell incubator (German Kendro)；Inverted microscope (ZESS), ultraviolet point
Light photometer (BioMate), SG-603 Biohazard Safety Equipment (Bake), ELx800 type microplate reader (BIO-TEK).
Method:
2.1 experimental drug
Herbal mixture of the present invention is set -20 DEG C of refrigerators and is saved.
Cell culture: being grown in the 1640 culture medium containing 10% fetal calf serum, is placed in 37 DEG C, 5%CO2 incubator, and every
Replace a subculture every 48h, when test, cell with digestive juice (disodium EDTA containing w=0.02% (EDTA) and
The trypsase of w=0.25% is prepared with 1: 1 ratio) digested, and be inoculated in 96 orifice plates or 100 culture dish of Φ in.
Method measures cell growth inhibition dose-effect relationship:
With 1 × 104Cells/well is inoculated with 96 hole plane culture plates, in 37 DEG C, 5%CO2, the CO of saturated humidity2Incubator culture 24 is small
When.If control group, Chinese medicine group, every group of 6 multiple holes, drug dose is 25 μ g/ml, 50 μ g/ml, 100 μ g/ml, 200 μ g/ml.
Continue culture 48 hours, remove culture supernatant, 100 ml of MTT of 0.5mg/ml is added in every hole, continues culture 4 hours, careful to inhale
Remove supernatant, and 100 μ l DMSO dissolution purple precipitating be added, in wavelength be 570nm(/ 630nm with microplate reader), measure OD value.It presses
Formula:
Inhibiting rate (%)=(1- experimental port be averaged A570/630 value/control wells be averaged A570/630 value) × 100%
2.5 statistical procedures
Continuous data application software spss13.0 carries out one-way analysis of variance, and the progress correlation analysis of the application software and song
Line fitting.
Experimental result
Influence of 3.1 Chinese medicine compound prescriptions to lung cancer A549 cell strain growth and form
Microscopically observation, cellular control unit adherent growth, cell boundary understand that mitosis figures are obvious；Chinese medicine compound prescription group cell
Clearly, cytoplasm is extremely coarse for profile, interior to be full of volume particulate material.
The influence that Chinese medicine compound prescription grows A549 cell
Chinese medicine can inhibit the growth of human lung carcinoma cell line A549 cell, and with the increase of drug concentration, to cell growth inhibition
It presents docs-effect dependence (being shown in Table 1, Fig. 1).
The inhibiting effect that 1 Chinese medicine compound prescription of table grows A549 cell
4. conclusion
4.1 Chinese medicine compound prescription experiment in vitro have good anti-lung cancer effect;
4.2 Chinese medicine compound prescription effect of anti-lung cancer are in dose dependent.
Two, clinical test
On the basis of drug test ensures safety, very good through clinical trial result, relevant information is as follows:
Through carrying out drug therapy of the present invention to the advanced pulmonary adenocarcinoma made a definite diagnosis 56, wherein the age is 50 years old minimum, 70 years old maximum, male
Female is fifty-fifty, and the course of disease is most 1 month short, longest 3 months, takes Chinese medicine 3 times of the present invention, each 1.5-2g, in the morning, afternoon and evening each 1 time daily, and 6
A month as a treatment course, and after treating, lung cancer foci disappearance, diminution, stabilization or slowly development are effectively reduced symptom, improve life
It bioplasm amount and extension life cycle, is statistically analyzed, the result is as follows:
1, life cycle after treating
| Life cycle | 3-6 months | - 1 year 6 months or more | - 1.5 years 1 year or more | - 2 years 1.5 years or more | 2 years or more |
| Number | 2 people | 5 people | 17 people | 26 people | 6 people |
2, quality of life improves situation: using Karnofsky standards of grading
| Classification | 100 | 90 | 80 | 70 | 60 | 50 | 40 |
| Number | 0 people | 2 people | 5 people | 12 people | 25 people | 8 people | 4 people |
3, lesion objective indicator improves situation
It should be apparent that survival rate can be improved to adenocarcinoma of lung in the present invention, symptom part alleviates up to 57% or more by above,
Getting well for its effect is unanticipated, is the big innovation treated on lung-cancer medicament, economic and social benefit is huge.
Claims (5)
1. a kind of Chinese medicine for treating lung cancer, which is characterized in that by poidometer: Radix Ophiopogonis 12-15 part, 9-12 parts of beggar-ticks, spina gleditsiae
3-6 parts, 3-6 parts of bush and 6-9 parts of Ramulus euonymi are made, and by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of weight are added
Volume, 85% ethyl alcohol of mass concentration impregnate 7 days, and primary every 12h concussion, each 5-10min is mixed, and filtering is condensed into 50 DEG C of phases
To the concentrated medicament of density 1.2-1.4, concentrated medicament is dried in vacuo, was ground into the fine powder that 120 mesh or more sieve.
2. the Chinese medicine for the treatment of lung cancer according to claim 1, which is characterized in that by poidometer: 12 parts of Radix Ophiopogonis, beggar-ticks
9 parts, 3 parts of spina gleditsiae, 3 parts of bush and 6 parts of Ramulus euonymi are made, and by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of weights are added
Volume, the immersion of 85% ethyl alcohol of mass concentration 7 days is measured, primary every 12h concussion, each 5min is mixed, and Rotary Evaporators are used in filtering
It is condensed into the concentrated medicament of 50 DEG C of relative density 1.2-1.4, concentrated medicament is put into vacuum oven and was dried, crushed into
The fine powder more than 120 mesh sieved.
3. the Chinese medicine for the treatment of lung cancer according to claim 1, which is characterized in that by poidometer: 13 parts of Radix Ophiopogonis, beggar-ticks
10 parts, 4 parts of spina gleditsiae, 4 parts of bush, 7 parts of Ramulus euonymi be made, by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of weights are added
Volume, the immersion of 85% ethyl alcohol of mass concentration 7 days is measured, primary every 12h concussion, each 7min is mixed, and Rotary Evaporators are used in filtering
It is condensed into the concentrated medicament of 50 DEG C of relative density 1.2-1.4, concentrated medicament is put into vacuum oven and was dried, crushed into
The fine powder more than 120 mesh sieved.
4. the Chinese medicine for the treatment of lung cancer according to claim 1, which is characterized in that by poidometer: 14 parts of Radix Ophiopogonis, beggar-ticks
11 parts, 5 parts of spina gleditsiae, 5 parts of bush, 8 parts of Ramulus euonymi be made, by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of weights are added
Volume, the immersion of 85% ethyl alcohol of mass concentration 7 days is measured, primary every 12h concussion, each 8min is mixed, and Rotary Evaporators are used in filtering
It is condensed into the concentrated medicament of 50 DEG C of relative density 1.2-1.4, concentrated medicament is put into vacuum oven and was dried, crushed into
The fine powder more than 120 mesh sieved.
5. the Chinese medicine for the treatment of lung cancer according to claim 1, which is characterized in that by poidometer: 15 parts of Radix Ophiopogonis, beggar-ticks
12 parts, 6 parts of spina gleditsiae, 6 parts of bush, 9 parts of Ramulus euonymi be made, by Radix Ophiopogonis, beggar-ticks, spina gleditsiae, bush, Ramulus euonymi, 10 times of weights are added
Volume, the immersion of 85% ethyl alcohol of mass concentration 7 days is measured, primary every 12h concussion, each 9min is mixed, and Rotary Evaporators are used in filtering
It is condensed into the concentrated medicament of 50 DEG C of relative density 1.2-1.4, concentrated medicament is put into vacuum oven and was dried, crushed into
The fine powder more than 120 mesh sieved.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117462620A (en) * | 2023-06-28 | 2024-01-30 | 河南中医药大学 | Traditional Chinese medicine formula for treating lung cancer and preparation method and application thereof |
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| CN102614354A (en) * | 2012-03-14 | 2012-08-01 | 高美 | Anticancer oral liquid and preparation method thereof |
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2018
- 2018-10-25 CN CN201811248141.XA patent/CN108992568A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614354A (en) * | 2012-03-14 | 2012-08-01 | 高美 | Anticancer oral liquid and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 史东升!300051: "中药宁肺片治疗肺癌34例临床观察", 《天津中医》 * |
| 张娟: "肺积方治疗肺癌体会", 《山东中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117462620A (en) * | 2023-06-28 | 2024-01-30 | 河南中医药大学 | Traditional Chinese medicine formula for treating lung cancer and preparation method and application thereof |
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Application publication date: 20181214 |
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