CN108992041A - Photoacoustic imaging system and method - Google Patents
Photoacoustic imaging system and method Download PDFInfo
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- CN108992041A CN108992041A CN201810871988.7A CN201810871988A CN108992041A CN 108992041 A CN108992041 A CN 108992041A CN 201810871988 A CN201810871988 A CN 201810871988A CN 108992041 A CN108992041 A CN 108992041A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 67
- 238000000034 method Methods 0.000 title claims abstract description 14
- 239000013307 optical fiber Substances 0.000 claims abstract description 138
- 230000005540 biological transmission Effects 0.000 claims abstract description 24
- 239000000835 fiber Substances 0.000 claims abstract description 21
- 238000001514 detection method Methods 0.000 claims abstract description 19
- 238000009987 spinning Methods 0.000 claims abstract description 5
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 229920000297 Rayon Polymers 0.000 claims description 4
- 239000000853 adhesive Substances 0.000 claims description 4
- 238000004026 adhesive bonding Methods 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 239000011230 binding agent Substances 0.000 claims description 4
- 238000007747 plating Methods 0.000 claims description 4
- 210000001367 artery Anatomy 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 abstract description 4
- 230000035515 penetration Effects 0.000 abstract description 3
- 210000002307 prostate Anatomy 0.000 description 19
- 238000010586 diagram Methods 0.000 description 12
- 238000004590 computer program Methods 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 4
- 210000003708 urethra Anatomy 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
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- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Medical Informatics (AREA)
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- Surgery (AREA)
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- General Health & Medical Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
The invention discloses a kind of photoacoustic imaging system and methods, the system includes laser light source, optical fiber, detection device and controller, the light exit side mouth of optical fiber is equipped with laser reflecting device, the ontology of light exit side mouth and optical fiber is at predetermined angle, optical fiber slip ring is arranged on the ontology of optical fiber, optical fiber is used for transmission the laser of laser light source transmitting, laser reflecting device is used for the laser reflection that is emitted light exit side mouth to target area, optical fiber slip ring is used to control fiber spinning when optical fiber transmits laser, detection device is for detecting the photoacoustic signal that target area generates upon laser irradiation, controller is used to generate the image of target area according to photoacoustic signal.Laser reflecting device, the penetration depth that enhancing laser light is shone is arranged in the light exit side mouth of optical fiber in the present invention.It is thus possible to improve the laser efficiency of transmission and signal-to-noise ratio of photoacoustic imaging system.Fiber spinning is controlled using optical fiber slip ring, multi-faceted laser irradiation is realized to target target area, improves the laser irradiation area of photoacoustic imaging system.
Description
Technical field
The present invention relates to technical field of photoacoustic more particularly to a kind of photoacoustic imaging system and methods.
Background technique
This part intends to provides background or context for the embodiment of the present invention stated in claims.Description herein
Recognize it is the prior art not because not being included in this section.
Photoacoustic imaging technology is widely used in the detection and imaging of biological tissue.In photoacoustic imaging technology, pass through spy
Survey the photoacoustic signal that the target target area being irradiated with a laser generates, the light absorption figure of available target target area.For target,
The quality of photoacoustic imaging is heavily dependent on the mode of laser irradiation.If carrying out light irradiation to intracorporal body of gland in vitro,
It is easy to receive the optical attenuation of peripheral organization and cause illumination transmitted intensity insufficient.For the photoacoustic imaging of prostate, usually
Optical fiber per urethra is subjected to laser irradiation to prostate, and per urethra carries out laser irradiation to target target area, and laser can be improved
The transmitted intensity of irradiation.
But in laser transmission mode used by existing photoacoustic imaging, laser is being irradiated to target from fiber end face
When target area, due to the influence that the target district's groups around fiber end face are knitted etc., the efficiency of transmission of laser is reduced, light is thus caused
The noise of acoustic imaging is relatively low, image quality is bad.
Therefore, there is laser transmission efficiency is low, signal-to-noise ratio is lower in existing photoacoustic imaging system.
Summary of the invention
The embodiment of the present invention provides a kind of photoacoustic imaging system and method, and the laser to improve photoacoustic imaging system transmits
Efficiency and signal-to-noise ratio, the system include laser light source, optical fiber, detection device and controller；
The light exit side mouth of the optical fiber is equipped with laser reflecting device, the ontology of the light exit side mouth and the optical fiber at
Predetermined angle is arranged with optical fiber slip ring on the ontology of the optical fiber；
The optical fiber is used for transmission the laser of the laser light source transmitting, and the laser reflecting device is for going out the light
The laser reflection of port outgoing is penetrated to target target area, the optical fiber slip ring is used to control the light when the optical fiber transmits laser
Fibre rotation, the detection device is for detecting the photoacoustic signal that the target target area generates upon laser irradiation, the controller
For generating the image of the target target area according to the photoacoustic signal.
The embodiment of the present invention also provides a kind of method for carrying out photoacoustic imaging using system described in above-described embodiment, described
Method includes:
The optical fiber transmits the laser of the laser light source transmitting；
The laser reflection that the light exit side mouth is emitted by the laser reflecting device is to target target area；
The optical fiber slip ring controls the fiber spinning when the optical fiber transmits laser；
The photoacoustic signal that target target area generates upon laser irradiation described in the detection；
The controller generates the image of the target target area according to the photoacoustic signal.
In the embodiment of the present invention, laser reflecting device is set in the light exit side mouth of the optical fiber, is emitted to reflected light
The laser of port outgoing, the penetration depth that enhancing laser light is shone.Therefore, it compared with traditional laser transmission mode, can be improved
The laser efficiency of transmission of photoacoustic imaging system and the signal-to-noise ratio of photoacoustic imaging system.In addition, utilizing light in the embodiment of the present invention
Fine slip ring controls fiber spinning, multi-faceted laser irradiation can be realized to target target area, it is thus possible to improve photoacoustic imaging system
The laser irradiation area of system.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.In the accompanying drawings:
Fig. 1 is the schematic diagram of photoacoustic imaging system provided in an embodiment of the present invention；
Fig. 2 a is a schematic diagram of fiber section structure in photoacoustic imaging system provided in an embodiment of the present invention；
Fig. 2 b is another schematic diagram of fiber section structure in photoacoustic imaging system provided in an embodiment of the present invention；
Fig. 2 c is the another schematic diagram of fiber section structure in photoacoustic imaging system provided in an embodiment of the present invention；
Fig. 3 is the flow chart of acousto-optic imaging method provided in an embodiment of the present invention.
Specific embodiment
Understand in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, with reference to the accompanying drawing to this hair
Bright embodiment is described in further details.Here, the illustrative embodiments of the present invention and their descriptions are used to explain the present invention, but simultaneously
It is not as a limitation of the invention.
Fig. 1 shows the structural representation of photoacoustic imaging system provided in an embodiment of the present invention, for ease of description, illustrating only
Part related to the embodiment of the present invention, details are as follows:
As shown in Figure 1, a kind of photoacoustic imaging system 10, the photoacoustic imaging system 10 includes laser light source 100, optical fiber
200, detection device 300 and controller 400.The light exit side mouth of the optical fiber 200 is equipped with laser reflecting device.
In addition, Fig. 2 a (one schematic diagram of fiber section structure) or Fig. 2 b (another schematic diagram of fiber section structure) is please referred to,
The ontology of the light exit side mouth and the optical fiber 200 is arranged with optical fiber slip ring on the ontology of the optical fiber 200 at predetermined angle
500。
In the photoacoustic imaging system 10, the optical fiber 200 is used for transmission the laser that the laser light source 100 emits,
The laser reflecting device is used for the laser reflection that is emitted the light exit side mouth to target target area, the optical fiber slip ring 500
It is rotated for controlling the optical fiber 200 when the optical fiber 200 transmits laser.The detection device 300 is for detecting the mesh
The photoacoustic signal that target area generates upon laser irradiation, the controller 400 are used to generate the mesh according to the photoacoustic signal
The image in target area.
In embodiments of the present invention, laser reflecting device is set in the light exit side mouth of the optical fiber 200, to reflected light
The laser of exit ports outgoing, the penetration depth that enhancing laser light is shone.Therefore, compared with traditional laser transmission mode, this hair
The laser efficiency of transmission of photoacoustic imaging system 10 and the signal-to-noise ratio of photoacoustic imaging system 10 can be improved in bright embodiment.In addition,
Optical fiber 200 is controlled using optical fiber slip ring 500 in the embodiment of the present invention to rotate, and multi-faceted laser spoke can be realized to target target area
According to it is thus possible to improve the laser irradiation area of photoacoustic imaging system 10.
Setting for the predetermined angle of the ontology of the light exit side mouth and optical fiber 200 of the optical fiber 200, there may be more
Kind mode.For example, the light exit side mouth of the optical fiber 200 and the predetermined angle of the ontology of optical fiber 200 can be set to
40 degree, or it is set as 60 degree.Obviously by the predetermined angle of the light exit side mouth of the optical fiber 200 and the ontology of optical fiber 200
It is set as 40 degree or is set as 60 degree, only certain exemplary illustration, those skilled in the art can also be according to practical feelings
Condition or actual demand set other for the predetermined angle of the light exit side mouth of the optical fiber 200 and the ontology of optical fiber 200
Angle.
In a further embodiment, the predetermined angle is the unspecified angle in 40 degree to 60 degree.Further
In embodiment, the predetermined angle is 45 degree.That is the light exit side mouth of optical fiber 200 and the ontology of optical fiber 200 is at 45 degree.
Fig. 2 a shows a structural representation of fiber section in photoacoustic imaging system provided in an embodiment of the present invention, for convenient for
Description, only parts related to embodiments of the present invention are shown, and details are as follows:
In a further embodiment, described to swash in order to improve the efficiency of transmission of laser in the photoacoustic imaging system 10
Light reflecting device includes reflectance coating 600, and the plating of reflectance coating 600 is located on the light exit side mouth of the optical fiber 200.Using institute
The light exit side mouth plating for stating optical fiber 200 sets the mode of reflectance coating 600, and to improve laser efficiency of transmission, enhancing laser penetrates depth
Degree.Compared to traditional reflecting mirror, reflectance coating is set in the plating of light exit side mouth, the effect and performance of laser reflection can be improved, into
And increases the energy of propagation of intense laser beam and improve the efficiency of laser transmission.
Fig. 2 b shows another structural representation of fiber section in photoacoustic imaging system provided in an embodiment of the present invention, for just
In description, only parts related to embodiments of the present invention are shown, and details are as follows:
In a further embodiment, described to swash in order to improve the efficiency of transmission of laser in the photoacoustic imaging system 10
Light reflecting device includes right-angle prism 700, and the right-angle prism 700 is fixed on the light of the optical fiber 200 by adhesive bonding
On exit ports.By the way of being adhesively fixed right-angle prism 700 on the light exit side mouth of the optical fiber 200, Ke Yizeng
The transmission energy of light laser, improves the efficiency of transmission of laser.
Specifically, one right-angle surface of the right-angle prism 700 is adhesively fixed in the light of the optical fiber 200 by adhesive
On exit ports, when the predetermined angle is 45 degree, the laser of the light exit side mouth transmitting is perpendicular to a right angle
The mode in face is radiated on the right-angle prism 700, and the inclined-plane of the right-angle prism 700 is to being radiated at the right-angle prism 700
On laser reflected, the laser after reflection is radiated in a manner of perpendicular to another right-angle surface of the right-angle prism 700
Most of laser being radiated on the right-angle prism 700 are almost reflected in target target area.Therefore, the present invention is implemented
Laser is reflected using right-angle prism 700 in example, the efficiency of transmission of laser can be improved.
Fig. 2 c shows the another structural representation of fiber section in photoacoustic imaging system provided in an embodiment of the present invention, for just
In description, only parts related to embodiments of the present invention are shown, and details are as follows:
In embodiment, the light exit side mouth of optical fiber 200 is vertical with the ontology of optical fiber 200 at 90 degree, the right-angle prism
700 are fixed on the light exit side mouth of the optical fiber 200 by adhesive bonding.Specifically, being 90 degree in the predetermined angle
When, the laser of the light exit side mouth transmitting is radiated on the right-angle prism 700 in a manner of perpendicular to a right-angle surface,
The inclined-plane of the right-angle prism 700 reflects the laser being radiated on the right-angle prism 700, and the laser after reflection is to hang down
Directly be radiated at target target area in the mode of another right-angle surface of the right-angle prism 700, almost by it is most of be radiated at it is described straight
Laser on angle prism 700 is reflected, and realizes side polishing.Therefore, laser equally can be improved in the embodiment of the present invention
Efficiency of transmission.
In a further embodiment, described adhesive is ultraviolet viscose binder.Ultraviolet viscose binder is widely used in light
Source solidification, such as point light source, light-pulse generator etc..Utilize the fixed right-angle prism 700 of ultraviolet glue adhesive bonding and optical fiber 200
Light exit side mouth, it is not easy to make beam spot deformation.In addition, ultraviolet viscose binder compared to other adhesives, be not easy to make it is described straight
Angle prism 700 falls off from the light exit side mouth of the optical fiber 200.
In a further embodiment, the optical fiber slip ring 500 is used for when the optical fiber 200 transmits laser described in control
Optical fiber 200 rotates
The optical fiber slip ring 500 is used to control the optical fiber 200 when the optical fiber 200 transmits laser according to preset rotation speed
Rotation；Alternatively, the optical fiber slip ring 500 is used to control the optical fiber 200 when the optical fiber 200 transmits laser according to preset angle
Degree rotation；Alternatively, the optical fiber slip ring 500 is used to control the optical fiber 200 when the optical fiber 200 transmits laser according to default
Radian rotation.
The preset rotation speed is preset tachometer value, specifically, for example described optical fiber slip ring 500 controls the optical fiber
200 rotate according to 100 revs/min of revolving speed, so that the laser irradiation direction of light exit side mouth transmitting changes from current location
Become another location.
The predetermined angle is preset angle value, specifically, for example the optical fiber can be controlled with optical fiber slip ring 500
200 rotate according to 15 degree of angle, so that the laser irradiation direction of light exit side mouth transmitting is changed into separately from current location
One position.
The default radian is preset radian value, specifically, for example described optical fiber slip ring 500 controls the optical fiber
200 rotate according to the radian of π/8, so that the laser irradiation of light exit side mouth transmitting is another towards changing into from current location
Position.
In a further embodiment, the laser light source 100 is OPO (Optical Parametric
Oscillation, optical parametric oscillator) pulse laser, the pulsewidth of OPO pulse laser transmitting laser is 5 nanoseconds, again
Complex frequency is 20 hertz, and single pulse energy metric density is that 10 millijoules are every square centimeter.Meanwhile 10 millijoule list every square centimeter
20 millijoule of secure threshold that pulse energy density fully meets human body is every square centimeter.
In a further embodiment, the detection device 300 includes arrayed ultrasonic transducer.Compared to other ultrasounds
For energy converter, arrayed ultrasonic transducer can detect photoacoustic signal, therefore will not be to human body without placing in vivo through body surface
Generate additional wound.
In a further embodiment, the controller 400 includes touch-control all-in-one machine.The controller 400 further includes packet
Containing display device, such as display, computer equipment.
In a further embodiment, the photoacoustic imaging system 10 further includes fiber coupler, the fiber coupling
Device is connected between the laser light source 100 and the optical fiber 200.The fiber coupler can make laser light source 100 send out
The laser energy penetrated can further improve swashing for photoacoustic imaging system 10 to be transmitted to the optical fiber 200 to greatest extent
Light transmissioning efficiency.
Specifically, above-mentioned photoacoustic imaging system 10 can be applied to the photoacoustic imaging of prostate.For example, when the optoacoustic at
When being applied to the photoacoustic imaging of prostate as system 10, before the photoacoustic imaging system 10 work, the optical fiber 200 can be passed through
Urethra insertion prostate is crossed, makes the light exit side mouth of the optical fiber 200 towards prostate region, in the photoacoustic imaging system 10
When work, the laser light source 100 emits laser, and the optical fiber 200 transmits the laser that the laser light source 100 emits, described
To prostate region, the group of prostate region is woven in the laser reflection that laser reflecting device is used to for the light exit side mouth being emitted
Photoacoustic signal, tissue of the detection device 300 to the illuminated prostate region are generated after receiving the irradiation of laser
The photoacoustic signal of generation is detected, and the controller 400 is according to the photoacoustic signal generation that the detection device 300 detects
The photoacoustic image of illuminated prostate region.Laser reflecting device is set in the light exit side mouth of the optical fiber 200, with reflection
The laser of light exit side mouth transmitting, to enhance the transmitted intensity of laser light photograph, compared to traditional laser transmission mode,
The laser efficiency of transmission and signal-to-noise ratio of photoacoustic imaging system 10 can be improved in the embodiment of the present invention, and then improves to the prostate
The photoacoustic imaging quality in region.
In order to improve the laser irradiation area of the prostate region, the optical fiber slip ring 500 can be in the optical fiber 200
It controls the optical fiber 200 when transmitting laser to rotate, to change the irradiation direction of the light exit side mouth laser.For example, current institute
The laser for stating light exit side mouth is the first position for irradiating prostate region, before the laser irradiation in order to make the light exit side mouth
The second position in column gland region, the optical fiber slip ring 500 controls the optical fiber 200 and is rotated, so that postrotational optical fiber 200
Light exit side mouth laser towards the second position.Therefore, the optical fiber slip ring 500 is revolved by controlling the optical fiber 200
Turn, can control the direction of illumination of the light exit side mouth laser, multi-faceted laser irradiation is carried out to the prostate region,
It is thus possible to improve the laser irradiation area of the prostate region.
In addition, the photoacoustic imaging system 10 in the embodiment of the present invention can be applied not only to the urinary system comprising urethra
Photoacoustic imaging can also be applied to the photoacoustic imaging that the outer cavity of connector realizes intracorporeal organ.For example, can be by the optical fiber
200 realize that the photoacoustic imaging etc. to digestive system, the photoacoustic imaging system 10 are applied to the outer cavity of connector and realize through esophagus
When the photoacoustic imaging of intracorporeal organ, principle and the photoacoustic imaging system 10 are applied to the above-mentioned urinary system comprising prostate
Principle it is similar, specifically can refer to foregoing description, details are not described herein again.
Fig. 3 shows the implementation process of acousto-optic imaging method provided in an embodiment of the present invention, according to different requirements, the stream
The sequence of step can change in journey figure, and certain steps can be omitted, and for ease of description, illustrate only and the embodiment of the present invention
Relevant part, details are as follows:
As shown in figure 3, acousto-optic imaging method, is applied in the photoacoustic imaging system 10 described in any of the above-described embodiment, institute
Stating acousto-optic imaging method includes:
Step S101, the optical fiber 200 transmit the laser that the laser light source 100 emits.
Step S102, the laser reflection that the light exit side mouth is emitted by the laser reflecting device to target target area.
Step S103, the optical fiber slip ring 500 control the optical fiber 200 when the optical fiber 200 transmits laser and rotate.
Step S104, the detection device 300 detect the photoacoustic signal that the target target area generates upon laser irradiation.
Step S105, the controller 400 generate the image of the target target area according to the photoacoustic signal.
Specifically, the optical fiber 200 can be inserted into cavity before the photoacoustic imaging system 10 work, make the optical fiber
200 light exit side mouth is towards target target area, and in the photoacoustic imaging system 10 work, the transmitting of laser light source 100 swashs
Light, the optical fiber 200 transmit the laser that the laser light source 100 emits, and the laser reflecting device is for the light to be emitted
For the laser reflection of port outgoing to target target area, the group of target target area generates photoacoustic signal after being woven in the irradiation for receiving laser,
The photoacoustic signal that the detection device 300 generates the tissue of the illuminated target target area detects, the controller
400 generate the photoacoustic image of the illuminated target target area according to the photoacoustic signal of the detection device 300 detection.
The embodiment of the present invention is arranged laser reflecting device in the light exit side mouth of the optical fiber 200, is gone out with reflecting the light
The laser of port transmitting is penetrated, to enhance the transmitted intensity of laser light photograph, compared to traditional laser transmission mode, the present invention is real
Applying example can be improved the laser efficiency of transmission and signal-to-noise ratio of photoacoustic imaging system 10, and then improve the optoacoustic to the target target area
Image quality.It rotates, target target area can be realized in addition, controlling optical fiber 200 using optical fiber slip ring 500 in the embodiment of the present invention
Multi-faceted laser irradiation, it is thus possible to improve the laser irradiation area of photoacoustic imaging system 10.
In a further embodiment, step S103, the optical fiber slip ring 500 transmit laser time control in the optical fiber 200
Making the rotation of optical fiber 200 includes:
(1) optical fiber slip ring 500 controls the optical fiber 200 when the optical fiber 200 transmits laser according to preset rotation speed
Rotation.
The preset rotation speed is preset tachometer value, specifically, for example described optical fiber slip ring 500 controls the optical fiber
200 rotate according to 100 revs/min of revolving speed, so that the laser irradiation direction of light exit side mouth transmitting changes from current location
Become another location.
Alternatively, (2) described optical fiber slip ring 500 controls the optical fiber 200 when the optical fiber 200 transmits laser according to default
Angle rotation.
The predetermined angle is preset angle value, specifically, for example the optical fiber can be controlled with optical fiber slip ring 500
200 rotate according to 15 degree of angle, so that the laser irradiation direction of light exit side mouth transmitting is changed into separately from current location
One position.
Alternatively, (3) described optical fiber slip ring 500 controls the optical fiber 200 when the optical fiber 200 transmits laser according to default
Radian rotation.
The default radian is preset radian value, specifically, for example described optical fiber slip ring 500 controls the optical fiber
200 rotate according to the radian of π/8, so that the laser irradiation of light exit side mouth transmitting is another towards changing into from current location
Position.
In embodiments of the present invention, optical fiber 200 is controlled according to preset rotation speed using optical fiber slip ring 500, or according to default arc
Degree, or rotated according to predetermined angle, it can control the direction of illumination of the light exit side mouth laser, to the prostate region
Multi-faceted laser irradiation is carried out, the laser irradiation area of the prostate region is improved.
Specifically, above-mentioned acousto-optic imaging method can be applied to the photoacoustic imaging to prostate, connection can also be applied to
External cavity realizes the photoacoustic imaging of intracorporeal organ, can specifically retouch with reference to related embodiment in above-mentioned photoacoustic imaging system 10
It states, details are not described herein again.
It should be understood by those skilled in the art that, the embodiment of the present invention can provide as method, system or computer program
Product.Therefore, complete hardware embodiment, complete software embodiment or reality combining software and hardware aspects can be used in the present invention
Apply the form of example.Moreover, it wherein includes the computer of computer usable program code that the present invention, which can be used in one or more,
The computer program implemented in usable storage medium (including but not limited to magnetic disk storage, CD-ROM, optical memory etc.) produces
The form of product.
The present invention be referring to according to the method for the embodiment of the present invention, the process of equipment (system) and computer program product
Figure and/or block diagram describe.It should be understood that every one stream in flowchart and/or the block diagram can be realized by computer program instructions
The combination of process and/or box in journey and/or box and flowchart and/or the block diagram.It can provide these computer programs
Instruct the processor of general purpose computer, special purpose computer, Embedded Processor or other programmable data processing devices to produce
A raw machine, so that being generated by the instruction that computer or the processor of other programmable data processing devices execute for real
The device for the function of being specified in present one or more flows of the flowchart and/or one or more blocks of the block diagram.
These computer program instructions, which may also be stored in, is able to guide computer or other programmable data processing devices with spy
Determine in the computer-readable memory that mode works, so that it includes referring to that instruction stored in the computer readable memory, which generates,
Enable the manufacture of device, the command device realize in one box of one or more flows of the flowchart and/or block diagram or
The function of being specified in multiple boxes.
These computer program instructions also can be loaded onto a computer or other programmable data processing device, so that counting
Series of operation steps are executed on calculation machine or other programmable devices to generate computer implemented processing, thus in computer or
The instruction executed on other programmable devices is provided for realizing in one or more flows of the flowchart and/or block diagram one
The step of function of being specified in a box or multiple boxes.
Particular embodiments described above has carried out further in detail the purpose of the present invention, technical scheme and beneficial effects
Describe in detail it is bright, it should be understood that the above is only a specific embodiment of the present invention, the guarantor being not intended to limit the present invention
Range is protected, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should be included in this
Within the protection scope of invention.
Claims (10)
1. a kind of photoacoustic imaging system, which is characterized in that including laser light source, optical fiber, detection device and controller；
The light exit side mouth of the optical fiber is equipped with laser reflecting device, and the ontology of the light exit side mouth and the optical fiber is at default
Angle is arranged with optical fiber slip ring on the ontology of the optical fiber；
The optical fiber is used for transmission the laser of the laser light source transmitting, and the laser reflecting device is used for the light exit side
For the laser reflection of mouth outgoing to target target area, the optical fiber slip ring is used to control the optical fiber rotation when the optical fiber transmits laser
Turn, for detecting the photoacoustic signal that the target target area generates upon laser irradiation, the controller is used for the detection device
The image of the target target area is generated according to the photoacoustic signal.
2. the system as claimed in claim 1, which is characterized in that the laser reflecting device includes reflectance coating, the reflectance coating
Plating is located on the light exit side mouth of the optical fiber.
3. the system as claimed in claim 1, which is characterized in that the laser reflecting device includes right-angle prism, the right angle
Prism is fixed on the light exit side mouth of the optical fiber by adhesive bonding.
4. system as claimed in claim 3, which is characterized in that described adhesive is ultraviolet viscose binder.
5. the system as claimed in claim 1, which is characterized in that the optical fiber slip ring is further used for:
The optical fiber is controlled when the optical fiber transmits laser to rotate according to preset rotation speed；Or
The optical fiber is controlled when the optical fiber transmits laser to rotate according to predetermined angle.
6. the system as claimed in claim 1, which is characterized in that the laser light source is OPO pulse laser, the OPO arteries and veins
The pulsewidth for rushing laser transmitting laser was 5 nanoseconds, repetition rate is 20 hertz, and single pulse energy metric density is 10 every square of millijoules
Centimetre.
7. the system as claimed in claim 1, which is characterized in that the detection device includes arrayed ultrasonic transducer.
8. the system as claimed in claim 1, which is characterized in that the controller includes touch-control all-in-one machine.
9. the system as claimed in claim 1, which is characterized in that further include fiber coupler, the fiber coupler is connected to
Between the laser light source and the optical fiber.
10. a kind of method for carrying out photoacoustic imaging using the described in any item systems of claim 1-8 characterized by comprising
The optical fiber transmits the laser of the laser light source transmitting；
The laser reflection that the light exit side mouth is emitted by the laser reflecting device is to target target area；
The optical fiber slip ring controls the fiber spinning when the optical fiber transmits laser；
The photoacoustic signal that target target area generates upon laser irradiation described in the detection；
The controller generates the image of the target target area according to the photoacoustic signal.
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| CN201810871988.7A CN108992041A (en) | 2018-08-02 | 2018-08-02 | Photoacoustic imaging system and method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810871988.7A CN108992041A (en) | 2018-08-02 | 2018-08-02 | Photoacoustic imaging system and method |
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