KR20150051131A - Method and apparatus for excitation pulse scanning in photoacoustic tomography - Google Patents
Method and apparatus for excitation pulse scanning in photoacoustic tomography Download PDFInfo
- Publication number
- KR20150051131A KR20150051131A KR1020140087337A KR20140087337A KR20150051131A KR 20150051131 A KR20150051131 A KR 20150051131A KR 1020140087337 A KR1020140087337 A KR 1020140087337A KR 20140087337 A KR20140087337 A KR 20140087337A KR 20150051131 A KR20150051131 A KR 20150051131A
- Authority
- KR
- South Korea
- Prior art keywords
- laser beam
- excitation
- laser
- optical fiber
- photoacoustic
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
Abstract
According to an aspect of the present invention, there is provided an optical pickup apparatus, comprising: a rotating reflector that receives an excitation laser beam generated from a laser beam generator and reflects the excitation laser beam at a predetermined angle and reflects the reflected excitation laser beam by rotation; A plurality of optical coupling lenses disposed on a circumferential surface having a predetermined radius from the rotational reflecting mirror and centered on the rotational reflecting mirror, the optical coupling lenses being sequentially reflected by the rotation of the rotational reflecting mirror, And a plurality of optical fiber strands connected to the plurality of optical coupling lenses, respectively, for guiding the laser beams incident on the optical coupling lens to the photoacoustic probes, respectively; The excitation light scanning device for a photoacoustic image is provided.
Description
The present invention relates to an excitation light scanning method and apparatus for photoacoustic imaging to obtain photoacoustic tomography of a living tissue.
The present invention discloses a method for scanning an excitation light for a photoacoustic image. The present invention relates to a technique for irradiating light of a short pulse to a living tissue target and collecting ultrasound generated in response to the irradiated light to obtain tomographic images inside the living tissue .
For this purpose, a laser light source with pulse widths of several nanoseconds and pulse energies of several mJs is used to detect the ultrasound signals generated by the subject, and ultrasonic sensors are used to detect the signals. Can be imaged.
To obtain a photoacoustic tomographic image, a short-pulse excitation laser light source technique having a high pulse energy is required. By irradiating such a light source to a biological tissue object to be imaged, an ultrasound signal can be detected in the irradiated area .
Therefore, short pulse excitation laser source technology with high pulse energy is required to obtain photoacoustic tomographic images, and these lasers are large in price and size.
In the prior art document 1, a multi-ultrasound measuring device (transducer) is configured to be coupled to the surface of a living tissue in order to derive a biological image including a light wave absorption characteristic in a living tissue, A photoacoustic breast scanner technique is disclosed that facilitates obtaining images.
Also, in the prior art document 2, there is a scanner technology in which an optical fiber is firmly fixed to a conductor loop in a longitudinal direction of the optical fiber, and a distal end portion of the optical fiber acts as a cantilever and can move. The scanner includes an optical fiber scanner (Prior Art 2, Optical fiber lateral scanner for (a), which is composed of a permanent magnet and a conductor loop functioning as an electromagnet, and controls the movement of the end of the optical fiber by modulating the current applied to the conductor loop miniature optical fiber probe) technology has been disclosed.
In the prior art, a Fabry-Perot interference film sensor head having a parylene C polymer as a spatial layer is contacted with an object to be imaged to detect the generated ultrasonic signal, and a nano-second pulse The ultrasonic waves generated in the object can modulate the spatial layer of the sensor head and detect the ultrasonic waves in the interfering film sensor head. The Fabry-Perot interference film is used to optically detect the displacement of the spatial layer over time, i.e., ultrasound. By focusing the probe laser with the wavelength-modulated transmission slope of the interference film on the Fabry-Perot interfering film sensor head and scanning it, the modulation of the reflected light with time is measured to obtain the distribution and tomographic image of the ultrasonic wave giving modulation of the spatial layer (3) technique is disclosed in which the " three-dimensional noninvasive imaging of the vasculature in the mouse brain using a high resolution photoacoustic scanner "
Conventional techniques have been able to detect ultrasound signals by broadly illuminating a subject of a living tissue to illuminate the light source. The light source thus used must have a very high light pulse energy. In addition, the conventional technique detects an ultrasonic signal by dividing a light source into a plurality of strands, and irradiating predetermined divided regions of the light source, which are respectively split, to a living tissue target.
In order to obtain a photoacoustic tomographic image, a conventional technique uses a high light pulse energy capable of irradiating a wide region or uses a light source by dividing the light source into a plurality of light sources. In order to distribute the light source to a plurality of light sources, There is a need for a high-energy excitation laser light source technology having a plurality of light outputs to satisfy the light output of the ship. These high energy laser pulsers are large in size and require large equipment costs.
In addition, if the energy per pulse is increased, the repetition rate may be lowered, and the speed (fps, frame rate) of the photoacoustic tomographic image may be low, so real-time image acquisition may be difficult.
It is an object of the present invention to provide an efficient excitation light scanning device by sequentially irradiating pulsed laser light generated by a laser generator in succession to a target area to be measured with a plurality of sequentially delayed laser beams in a state in which the output is not divided .
The present invention relates to an apparatus and a method for measuring a laser beam having a relatively low pulse energy to irradiate excitation laser light with laser light pulses having a time delay to a plurality of predetermined measurement areas by a rotating reflector and collecting ultrasound signals in response thereto, The present invention also provides an excitation light scanning method and apparatus thereof capable of performing high-speed scanning with an apparatus.
According to an aspect of the present invention, there is provided a light source device comprising: a rotating reflector that receives an excitation laser beam generated from a laser beam generator and refracts the light beam at a predetermined angle and reflects the refracted excitation laser beam in a radial direction by rotation; A plurality of optical coupling lenses disposed on a circumferential surface having a certain radius from the rotating reflector and having a predetermined radius around the rotating reflector, the excitation laser beam being incident on the reflected laser beam with successive time intervals by the rotating reflector; And a plurality of optical fiber strands connected to the plurality of optical coupling lenses, respectively, for guiding the laser beams incident on the optical coupling lens to the photoacoustic probes, respectively; The excitation light scanning device for a photoacoustic image is provided.
Also, the photoacoustic probe may include at least two optical fiber matrix connection modules connected with the plurality of optical fiber strands connected to each other; A laser output surface having a plurality of laser output ports connected to the plurality of optical fiber strands connected through the optical fiber matrix connection module on a cross section toward a target tissue to output the laser light; And an ultrasonic sensor matrix module disposed adjacent to the laser output surface and receiving ultrasonic waves generated in the target tissue by the laser beam irradiated to the target tissue through the laser output port; .
The rotating reflector is coupled to a driving device that rotates at a high speed. As the rotating reflector is rotated, the excitation laser beam is sequentially reflected at a time interval and input through each of the plurality of optical coupling lenses in a radial direction .
Further, the rotating reflector is characterized by refracting the excitation laser beam at 90 degrees with an angle of 45 degrees or 135 degrees with the excitation laser beam.
The rotation phase of the rotating mirror is controlled so that the pulse of the laser beam is incident on the center of the optical coupling lens to which the laser beam is incident.
The ultrasonic sensor matrix is formed between the excitation laser output planes formed at both ends of the photoacoustic probe, and the optical fiber matrix connection module includes a photoacoustic sensor And is formed on both side end sides of one side of the probe.
The ultrasonic sensor matrix module may further include an ultrasonic absorber structure for preventing reflected waves of the inputted ultrasonic signals from being returned.
The ultrasonic sensor matrix module includes an ultrasonic focusing acoustic lens for efficiently detecting ultrasonic waves at a predetermined depth of the target tissue. The excitation light scanning module for a photoacoustic image
According to still another aspect of the present invention, there is provided a method of manufacturing a semiconductor laser, comprising: generating an excitation laser beam from a laser beam generator; Reflecting the generated excitation laser beam at a predetermined angle by a rotating reflector, and delivering the laser beam pulses reflected by the excitation laser beam at a sequential time interval by rotation; The laser light pulse being incident on a plurality of optical coupling lenses arranged in a circular shape with a predetermined radius and spaced apart from the rotating reflector about the rotational reflecting mirror; Guiding a laser light pulse incident on each of the plurality of optical coupling lenses to a photoacoustic probe by a plurality of optical fiber strands respectively connected to the plurality of optical coupling lenses; Irradiating laser light guided through the photoacoustic probe to a target tissue via a plurality of laser output ports; And an ultrasonic sensor matrix of the photoacoustic probe receiving ultrasound generated in the target tissue by the irradiated laser light; The method of scanning an excitation light for a photoacoustic image is provided.
According to an embodiment of the present invention, the high energy pulse laser beam generated by the laser generator is irradiated to a target area of the measurement target with a plurality of sequential time delayed laser beams in a state in which the output is not divided, And an excitation light scanning device capable of scanning at a high speed can be provided.
In addition, when the excitation laser beam irradiation position is taken into account in acquiring the photoacoustic tomographic image of the subject of the living tissue, the beam can be easily formed around the position in the direction of the ultrasonic sensor matrix in a relatively short time.
Also, it is possible to provide an excitation light scanning method and apparatus which can be manufactured at low cost by focusing and scanning a laser beam irradiated by a laser beam rotated at a high speed by a mechanical structure according to an embodiment of the present invention.
Also, according to an embodiment of the present invention, a photoacoustic signal can be acquired and imaged with a relatively low pulse energy.
In addition, according to an embodiment of the present invention, real-time photoacoustic tomographic images can be obtained by enabling high-speed scanning.
Further, the present invention is applicable to a photoacoustic tomographic image.
1 illustrates a structure of an integrated photoacoustic probe for receiving laser light excitation and ultrasonic waves for a photoacoustic image according to an embodiment of the present invention.
2 shows a structure of a laser delivery device for outputting an excitation laser beam according to an embodiment of the present invention.
3 is a view for explaining the traveling structure of the laser beam reflected by the rotating
FIG. 4 illustrates waveforms of a plurality of laser light pulses output from the laser scanning apparatus according to an exemplary embodiment of the present invention.
BRIEF DESCRIPTION OF THE DRAWINGS The present invention is capable of various modifications and various embodiments, and specific embodiments are illustrated in the drawings and described in detail in the detailed description. It should be understood, however, that the invention is not intended to be limited to the particular embodiments, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the present invention will be described with reference to the accompanying drawings.
The terms first, second, etc. may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another.
Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.
The present invention discloses a method and apparatus for enabling a pulse of relatively high light intensity to be used as an excitation light and enabling high-speed scanning thereof.
1 illustrates a structure of an integrated photoacoustic probe for receiving laser light excitation and ultrasonic waves for a photoacoustic image according to an embodiment of the present invention.
The
1, the optical fiber
According to an embodiment of the present invention, the
The output laser light is output to the
In addition, the optical fiber
In addition, the optical fiber
The excitation
In addition, the excitation
According to an embodiment of the present invention, an excitation
The
The
The ultrasonic focusing acoustic lens may be formed of a material such as silicone rubber having an acoustic impedance close to that of the subject. Further, the ultrasonic focusing acoustic lens can be converged at the center in a convex shape.
A plurality of ultrasonic sensors are disposed in the
The ultrasonic
The ultrasonic absorber structure may be made of an attenuating material having a low acoustic impedance.
The collected ultrasound detection signals are output as an electrical signal through the
Each detection signal can be electrically amplified and used, can be beam-formed around any position in the direction of the
According to an embodiment of the present invention, one end face of a plurality of optical fibers is used as an exit port of an excitation laser beam for a photoacoustic image, and the other end face is used for incidence and scanning of excitation light.
When a sequential laser beam pulse is irradiated to the skin, a specific ultrasonic wave is generated in a process of expanding and contracting internal tissues such as blood vessels due to the pulse of the laser beam at a predetermined depth of skin. When the specific ultrasonic signal matrix is imaged, Dimensional image showing the characteristic structure of the two-dimensional image.
That is, an ultrasound signal generated in response to a laser beam emitted from one optical fiber is an A scan signal obtained in a depth direction at a point of a biological object, and in the case of a B scan image obtained by sequentially combining the positions of an A scan ultrasonic wave, It is a two-dimensional image that can recognize the characteristic structure (different tissues and other inflammatory site cancer formation sites).
According to an embodiment of the present invention, the other cross section for the incidence and scanning of the excitation light is arranged along a circle which is an arrangement structure of the optical coupling lens.
2 shows a structure of a laser delivery device for outputting an excitation laser beam according to an embodiment of the present invention.
The
The
3 is a view for explaining a traveling path of the laser beam reflected by the
According to an exemplary embodiment of the present invention, the
However, the angle is for describing an embodiment, and in actual manufacture, the
The
The
Each of the plurality of
A plurality of
According to an embodiment of the present invention, the
FIG. 4 illustrates a plurality of laser light pulses input to or output from the laser delivery device according to an embodiment of the present invention.
The rotation of the
4, the pulse width w1 of the laser beam incident on the
The
One or more laser light pulses input through the
Each laser light input through the
A method of scanning an excitation light for a photoacoustic image according to an exemplary embodiment of the present invention includes: generating an excitation laser beam from a laser beam generator; Separating and reflecting the generated excitation laser beam in a radial direction by a rotating reflector; Sequentially irradiating laser light reflected by the rotating reflector onto a plurality of optical coupling lenses arranged in a circular shape with a predetermined radius with respect to the rotating reflecting mirror with the rotating reflecting mirror as a center; Guiding the laser light incident on the plurality of optical coupling lenses to a photoacoustic probe by a plurality of optical fiber strands connected to the plurality of optical coupling lenses; Irradiating the object through the laser output port of the waveguided laser light in the photoacoustic probe; And an ultrasonic sensor matrix of the photoacoustic probe receiving ultrasound generated in the target tissue by the irradiated laser light; And a control unit.
According to one embodiment of the present invention, the rotational phase of the
Or by rotating the entire position of the
According to an embodiment of the present invention, the excitation
According to an embodiment of the present invention, excitation laser light pulses are successively irradiated through the excitation
Generally, in order to irradiate a laser beam output from one laser generator to a wide region sequentially in the type of n, the output generated from one laser beam must be divided into n portions. In this case, The output generated by the laser generator is reduced to 1 / n. As a result, the output of the laser is required to be n times as large as that required in the laser output.
According to an embodiment of the present invention, when a laser beam output from one laser generator is sequentially distributed through an optical fiber and distributed through an optical fiber, the output generated from the laser beam is divided into output The laser beam can be transmitted to the laser output surface of the photoacoustic probe without irradiating the laser beam. Therefore, the laser beam can be irradiated to a wide area with a relatively small output as compared with the conventional laser beam generator.
That is, in the prior art in which the output of the excitation laser beam is divided into a plurality of laser beam paths for irradiating a wide area, an output that is twice as many as a divided number is required. On the other hand, The laser scanning apparatus is economical since laser light having a peak value output equal to the peak value of the excitation laser beam generated in the excitation laser beam generator can be uniformly irradiated over a wide range.
Considering the excitation laser beam irradiation position in the acquisition of the photoacoustic tomographic image of the subject of the living tissue, the laser generation output and the rotation speed are controlled to be easily centered at any position in the direction of the
According to an embodiment of the present invention, the laser
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but variations and modifications may be made by those skilled in the art without departing from the scope and spirit of the invention. Do.
100: photoacoustic probe
101: Ultrasonic sensor matrix
102: Ultrasonic sensor matrix module
103: ultrasonic detection signal line
111: fiber optic strand
112: Fiber-optic matrix connection module
113: laser light output face
114: laser light input stage
200: Laser scanning transmission device
201: excitation laser beam
202: rotating reflector
212: Optical coupling lens
Claims (12)
A plurality of optical coupling lenses disposed on a circumferential surface having a predetermined radius with respect to the rotating reflector, the plurality of optical connecting lenses being arranged such that the transmitted laser beams are sequentially incident on the rotating reflecting mirror; And
A plurality of optical fibers connected to the plurality of optical coupling lenses, respectively, for guiding the laser beams incident on the optical coupling lens to the optical acoustic probes;
A laser delivery device; And an excitation light scanning device for photoacoustic imaging
Wherein the photoacoustic probe comprises:
At least two optical fiber matrix connection modules to which the plurality of optical fiber strands are connected and connected;
An excitation laser output surface having a plurality of laser output ports connected to the plurality of optical fiber strands connected through the optical fiber matrix connection module on a cross section toward a target tissue to output the laser light; And
An ultrasonic sensor matrix module disposed adjacent to the laser output surface and receiving ultrasonic waves generated in the target tissue by the laser beam irradiated to the target tissue through the laser output port; The excitation light scanning device for a photoacoustic image according to claim 1,
The rotating reflector is coupled to a driving device rotating at high speed,
Characterized in that the excitation laser beam is successively separated and input through each of the plurality of optical coupling lenses as the rotating reflector is rotated.
Wherein the rotating reflector reflects the excitation laser beam at an angle of 90 degrees with an angle of 45 or 135 degrees with the excitation laser beam.
And the rotation phase of the laser beam is controlled so that a pulse of the laser beam is incident upon the rotation of the rotary reflector when the excitation laser beam comes to the center of the optical coupling lens to be incident.
Wherein the excitation laser output planes are respectively formed at both side end portions of the photoacoustic probe on the section, the ultrasonic sensor matrix is formed between the excitation laser output planes formed at the both end portions,
Wherein the optical fiber matrix connection module is formed on both side end sides of one end of the photoacoustic probe.
Wherein the excitation laser output surface is arranged at one side of the photoacoustic probe with a linear or constant pattern,
Wherein the optical fiber matrix connection module is arranged in a linear or constant pattern on one side of the photoacoustic probe.
Wherein the ultrasonic sensor matrix module further comprises an ultrasonic absorber structure for preventing the reflected wave of the inputted ultrasonic signal from being returned to the ultrasonic sensor matrix module.
Wherein the ultrasonic sensor matrix module includes an ultrasonic focusing acoustic lens for effectively detecting ultrasonic waves at a predetermined depth of the inspected object.
Reflecting the generated excitation laser beam at a predetermined angle by a rotating reflector, and sequentially transmitting laser light by rotation;
The laser light being incident on a plurality of optical coupling lenses arranged in a circular shape with a predetermined radius and spaced apart from the rotating mirror by a predetermined distance;
Guiding the laser light incident on the plurality of optical coupling lenses to a photoacoustic probe by a plurality of optical fiber strands respectively connected to the plurality of optical coupling lenses;
Irradiating laser light guided through the photoacoustic probe to a target tissue via a plurality of laser output ports; And
The ultrasonic sensor matrix of the photoacoustic probe receiving ultrasound generated from the target tissue by the irradiated laser light; Wherein the excitation light scanning method for a photoacoustic image
Wherein a rotation phase of the laser light is controlled such that a pulse of the laser light is incident when the rotation of the rotary reflector comes to the center of the optical coupling lens to which the laser light is incident.
Wherein the rotating reflector reflects the excitation laser beam at an angle of 90 degrees with an angle of 45 degrees or 135 degrees with the excitation laser beam.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/521,321 US20150119681A1 (en) | 2013-10-29 | 2014-10-22 | Method and apparatus for scanning excitation light for a photoacoustic image |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20130129436 | 2013-10-29 | ||
| KR1020130129436 | 2013-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20150051131A true KR20150051131A (en) | 2015-05-11 |
Family
ID=53388714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020140087337A KR20150051131A (en) | 2013-10-29 | 2014-07-11 | Method and apparatus for excitation pulse scanning in photoacoustic tomography |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR20150051131A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108992041A (en) * | 2018-08-02 | 2018-12-14 | 深圳先进技术研究院 | Photoacoustic imaging system and method |
| CN115568820A (en) * | 2022-09-05 | 2023-01-06 | 暨南大学 | All-fiber photoacoustic endoscopic imaging device and system based on far-end scanning |
| CN115670385A (en) * | 2022-11-03 | 2023-02-03 | 上海交通大学 | Intravascular fiber probe lateral three-dimensional scanning device and control method |
-
2014
- 2014-07-11 KR KR1020140087337A patent/KR20150051131A/en not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108992041A (en) * | 2018-08-02 | 2018-12-14 | 深圳先进技术研究院 | Photoacoustic imaging system and method |
| CN115568820A (en) * | 2022-09-05 | 2023-01-06 | 暨南大学 | All-fiber photoacoustic endoscopic imaging device and system based on far-end scanning |
| CN115670385A (en) * | 2022-11-03 | 2023-02-03 | 上海交通大学 | Intravascular fiber probe lateral three-dimensional scanning device and control method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210333241A1 (en) | Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection | |
| JP5294998B2 (en) | Ultrasonic probe, photoacoustic / ultrasonic system including the ultrasonic probe, and specimen imaging apparatus | |
| CN103654867A (en) | Imaging probe and imaging device with same | |
| CN104188625A (en) | Multimodal microscopic imaging system | |
| CN108606777B (en) | Photoacoustic computed tomography system based on adjustable focusing type optical fiber sensor | |
| US11432798B2 (en) | Portable probe for photoacoustic tomography and real-time photo acoustic tomography device | |
| US10209226B2 (en) | Photoacoustic microscope apparatus | |
| WO2012077356A1 (en) | Probe for photoacoustic inspection, and photoacoustic inspection device | |
| US20220133273A1 (en) | Transparent ultrasound transducers for photoacoustic imaging | |
| KR20150053630A (en) | Probe and medical imaging apparatus employing the same | |
| US20150094599A1 (en) | Varifocal lens, optical scanning probe including the varifocal lens, and medical apparatus including the optical scanning probe | |
| JP5864904B2 (en) | Biological information acquisition device | |
| KR20150051131A (en) | Method and apparatus for excitation pulse scanning in photoacoustic tomography | |
| US10349835B2 (en) | Optical switching unit, optical probe including the same, and medical imaging apparatus including optical probe | |
| US11399719B2 (en) | Probe for photoacoustic measurement and photoacoustic measurement apparatus including same | |
| CN112401847A (en) | Photoacoustic microscopic imaging system and method | |
| CN110584615A (en) | Bimodal endoscopic imaging system | |
| US20150119681A1 (en) | Method and apparatus for scanning excitation light for a photoacoustic image | |
| JP2014230631A (en) | Probe for photoacoustic measurement, and probe unit and photoacoustic measurement apparatus therewith | |
| JP2018130367A (en) | Optical transmission device, optical transmission method, and subject information acquisition device | |
| US20150374239A1 (en) | Object information acquiring apparatus and control method of object information acquiring apparatus | |
| WO2016084318A1 (en) | Inspection object information acquiring apparatus | |
| KR20150115323A (en) | Probe for optical tomography and optical coherence tomographic devices using thereof | |
| CN117687188A (en) | Time delay device, lattice Lu Nisen relaxation photoacoustic imaging method and system | |
| JP6005126B2 (en) | Probe unit, photoacoustic / ultrasonic probe, and object imaging system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Withdrawal due to no request for examination |