CN1089853A - Quick-acting antidiarrhea oral liquor for infant and preparation method - Google Patents
Quick-acting antidiarrhea oral liquor for infant and preparation method Download PDFInfo
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Abstract
The invention belongs to Chinese herbal and crude drugs preparations, relate to the quantitative approach of a kind of quick-acting antidiarrhea oral liquor for infant of new formulation and trace element (electrolyte) and improve the active and stable treatment technology of disaccharidase etc.Medicinal herb components of the present invention has: Polyporus, Rhizoma Atractylodis, Herba Pogostemonis, the Rhizoma Pinelliae, Fructus Hordei Germinatus, Borneolum Syntheticum, Fructus Rosae Laevigatae; Can add compositions such as Radix Paeoniae Rubra, Radix Bupleuri, Semen Plantaginis and Fructus Jujubae.The present invention extracts electrolyte and disaccharidase etc. to medicinal herb components.The present invention is the pure natural Chinese herbal and crude drugs preparations, has advantages such as onset is rapid, effect is comprehensive, with low cost, taking convenience.The present invention of clinical research proof can treat infantile rotavirus enteritis, promotes the body digestive and absorptive functions, and cure rate reaches 97.2%, and total effective rate reaches 100%.
Description
The invention belongs to Chinese herbal and crude drugs preparations (oral liquid), relate to the quantitative approach of a kind of novel quick-acting antidiarrhea oral liquor for infant and trace element (electrolyte) and improve the disaccharidase activity and journey treatment technology etc. qualitatively.
Do not find the oral liquid novel form of treatment children's diarrhae (rotavirus) at present as yet, nearest like product: in November, 92, new " children's is rushed down speed and the stopped " electuary of going into operation of Shiquan pharmaceutical factory was economized in effluent south, failed to solve and suffered from diarrhoea and problems such as the dehydration seen, electrolyte disturbance, disaccharidase deficiency; Children's is rushed down speed and is stopped electuary and prove through zoopery, enterokinesia there is obvious inhibitory action, and infect (rotavirus) property diarrhoea mainly be since this virion invades that epithelial cell-intestinal villi shortenings-epithelial cell mitochondrial swelling-endoplasmic reticulum of upper part of small intestine expands and the proper mucous membrane monokaryon soak into-make intestinal secretion water (electrolyte) ↑ → cause suffering from diarrhoea, little with the dynamic (dynamical) change relation of intestinal, so costive does not have obvious therapeutic action.
The novel infantile diarrhea treatment oral liquid that the present invention proposes, it can improve the activity of disaccharidase, reduces the enteral osmotic pressure, eliminate the intestinal epithelial cell mitochondrial swelling, reduce power and water and separate the matter secretory volume, thereby correct dehydration and electrolyte disturbance are treated watery diarrhea effectively.
The present invention's " electuary " that sugar content is higher changes the oral liquid of sugar-free (few sugar) into.
The present invention removes and take new medicinal herb components in the selection of composition, on oral liquid preparation technology's in the past basis, has adopted the quantitative approach of trace element (electrolyte) and has improved the disaccharidase activity and journey is handled new technique qualitatively.
Medicinal herb components of the present invention is selected to go up by traditional astringent therapy diarrhea-stopping exercise (it is main promptly suppressing the enterokinesia medicine), improves to be " diuretic diarrhea-stopping exercise " (promptly regulate the water liquid metabolic function of kidney, it is main reducing enteric cavity osmotic pressure medicine).
Medicinal herb components of the present invention has: Polyporus, Rhizoma Atractylodis, Herba Pogostemonis, the Rhizoma Pinelliae, Fructus Hordei Germinatus, Dens Draconis, Fructus Rosae Laevigatae, can add compositions such as Radix Paeoniae Rubra, Radix Bupleuri, Herba Plantaginis and Fructus Jujubae; Wherein: with the Polyporus promoting diuresis to eliminate damp pathogen, Rhizoma Atractylodis are drying damp and strengthening spleen, and the Herba Pogostemonis removing dampness to restore normal function of the stomach is main; The Fructus Hordei Germinatus dyspepsia and intestinal stasis relieving, Fructus Rosae Laevigatae is transferred the kidney QI invigorating, and behavior is assisted under the clear dampness removing of Herba Plantaginis, and Radix Bupleuri is evacuated and is brought down a fever the pain relieving of Radix Paeoniae Rubra yin fluid astringing, Dens Draconis is calmed the nerves relieving convulsion for helping, and for making, all medicines share with flavoring for Fructus Jujubae spleen reinforcing stomach reinforcing and all medicines, gather removing dampness antidiarrheal altogether, clearing away heat and resolving stagnation of food, reason spleen stomach function regulating, the merit of supplementing QI and nourishing YIN.
In the medicinal herb components of the present invention: the also available Poria of Polyporus replaces, Rhizoma Atractylodis can use Cortex Magnoliae Officinalis, Herba Pogostemonis to use Herba Eupatorii, Dens Draconis Os Draconis, the Rhizoma Pinelliae with Succus Bambusae, Radix Paeoniae Rubra with the Radix Paeoniae Alba, the Radix Aucklandiae, Radix Bupleuri with Radix Puerariae, Herba Portulacae, Herba Patriniae, Fructus Hordei Germinatus with Fructus Setariae Germinatus, Fructus Crataegi, Semen Plantaginis with Herba Plantaginis, Rhizoma Imperatae, Rhizoma Alismatis, Fructus Rosae Laevigatae with replacements such as Fructus Mume, catechu, Fructus Corni, Semen Lablab Album, Semen Euryales, Herba Euphorbiae Humifusae, Cortex Ziziphi spinosae Radicis, sour pomegranate skins.
Electrolytical extraction and quantitative approach:
To contain trace element (potassium, sodium, chlorine, calcium etc.) Chinese medicine, i.e. Dens Draconis (or Os Draconis) and Semen Plantaginis (or Herba Plantaginis) in the herb ingredients in the present invention, be solvent with water earlier, extract its effective ingredient, reuse ethanol makes content reach 50～60% and 70～80% respectively, successively remove destarching, impurity such as protein, again concentration of alcohol was transferred to 80～90% o'clock, can be settled out inorganic salts (electrolyte), carry out quantitative analysis with ultraviolet spectra or thin layer chromatography then, make potassium, sodium, chlorine, it is conformance with standard that calcium ion content is equivalent to 1/3～1/2 " ORS " (oral guarantor's liquid salt).
The extraction and the stability that transform carbohydrase (disaccharidase) are handled:
Use " saltouing-dialyse-freeze-drying ", promptly utilize different proteins in the saline solution of high concentration, dissolubility reduces and precipitates, thus with other component separating, remove inorganic salts a large amount of in the enzyme of being saltoutd through dialysis, again after lyophilization and the method for extracting.
Its select for use Fructus Hordei Germinatus among the present invention (or Fructus Setariae Germinatus, Fructus Crataegi) with water as solvent, consumption is 1～5 times of raw material weight.
Raw material: neutral salt, as ammonium sulfate, sodium sulfate, magnesium sulfate, sodium chloride etc.
Concentration: reach fractional precipitation in order to make range protein, the concentration of salt can increase progressively gradually, a certain protein behind salt precipitation, the salt that mother solution adds debita spissitudo again makes another kind of protein redeposition, can make range protein (enzyme) separate (general 50% → 60% → 70% → 80% → 90% → 100% one by one at last ...).
PH value: should grasp in the stability range of enzyme in principle, and should be away from the isoelectric point, IP (general PH7～7.4) of enzyme.
Temperature: 4 ℃ ± 0.5 ℃
Time: 5～30 minutes
Also can select for use sieve method (glucose gel Filtration) to extract disaccharidase (method is omitted, and sees national high medical college teaching material " pharmacy of Chinese materia medica " 1 edition P77～78 in 86 year November on probation for details) in addition.
Quick-acting antidiarrhea oral liquor for infant of the present invention is the pure natural Chinese herbal and crude drugs preparations, and it is rapid to have an onset, and effect is comprehensively, and is with low cost, advantages such as taking convenience, and clinical research proves: this product can be treated infantile rotavirus enteritis, promotes the body digestive and absorptive functions.Zoopery shows: 1, can strengthen intestinal mucosa cell disaccharidase activity, reduce the enteral osmotic pressure; 2, can promote gastric secretion intestinal mucosa is shunk and reduce secretes; 3, relieving spasm to stop pain, preventing or arresting vomiting, diuresis are arranged; 4, can suppress multiple diarrhea inducing virus and pathogen.See to wipe 389 examples through following up a case by regular visits to, cure 378 examples, account for 97.2%, 12 hours cure rates 71.5% wherein, total effective rate 100%.
The embodiment of the invention:
Composition: Polyporus (peeling) 600g, Rhizoma Atractylodis (stir-fry) 500g, Herba Pogostemonis 500g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 300g, Radix Paeoniae Rubra (stir-fry) 500g, Semen Plantaginis (salt is processed) 500g, Dens Draconis (fire section) 500g, Radix Bupleuri 500g, Fructus Rosae Laevigatae 500g, Fructus Hordei Germinatus 1000g, sodium benzoate 2.5g.
Method for making: (1) earlier with Dens Draconis decocting secondary, 3h first, and secondary 1.5h merges twice decocting liquid and filters, and filtrate is stored; Semen Plantaginis is wrapped the decocting secondary in addition, 2h first, secondary 1.5h filters after merging twice decocting liquid, and the filtrate of filtrate and Dens Draconis (or Os Draconis) merges the back effective component extracting: Semen Plantaginis alkali, Semen Plantaginis bmap acid; It is 50～60%, 70～80% that reuse ethanol transfers to concentration, removes impurity such as destarching, phlegmatic temperament, protein, again concentration is transferred to 80%～90%, precipitation inorganic salts, KCl, CaCl
2, NaCl, Ca
2CO
3Deng, through reclaim ethanol, decompression, concentrate, after the drying, using ultraviolet spectrometer carries out quantitative analysis, make potassium, sodium, chlorine, calcium ion content suitable 1/3～1/2 " ORS " standard in addition device store.
(2) with twice of Fructus Hordei Germinatus (or Fructus Setariae Germinatus, Fructus Crataegi) decocting, be respectively 2h, 1.5h, mix after-filtration, (concentration is by 50% → 60% → 70% → 80% for the refining NaCl powder of increment adding gradually ...) conversion carbohydrase, amylase, protease fractional precipitation in the Fructus Hordei Germinatus are got off, remove the inorganic salts of volume in the enzyme liquid of being saltoutd through " dialysis " again, behind concentrating under reduced pressure, cool-drying and extract and transform carbohydrase (disaccharidase), amylase, protease, adorn seal up for safekeeping in No. 5 hard capsules standby.
(3) with Polyporus, Radix Paeoniae Rubra, Fructus Rosae Laevigatae decocting twice, 2h first, secondary 1.5h, mix decocting liquid after-filtration twice, effective component extracting: Polyporus polysaccharide 1, Radix Paeoniae or, tannic acid etc., the residual liquid dress reservoir after the extraction leaves standstill.With Rhizoma Atractylodis, the Rhizoma Pinelliae, Herba Pogostemonis, Radix Bupleuri steam distillation, extract volatile oil device storage in addition again.Residue decocts with water filtration behind the 2h, filtrate to be mixed with the residual liquid of Polyporus, Radix Paeoniae Rubra, Fructus Rosae Laevigatae, Dens Draconis, Semen Plantaginis, Fructus Hordei Germinatus when being concentrated into the 1NL medicinal liquid and being equivalent to crude drug in whole 2g, put cold, triple 95% ethanol of adding medicinal liquid, stir evenly, static 24h, filter, add volatile oil, electrolyte, sodium benzoate, add an amount of distilled water again and transfer to 10000NL, cold preservation, filtration, be packaged in the ampoule of 10NL, 100 ℃ of sterilization 30min promptly.
The present invention can be used for: removing dampness, reason spleen, antidiarrheal; Transfer kidney, yin fluid astringing, pain relieving; Heat clearing away, stomach function regulating, preventing or arresting vomiting are used for the treatment of infantile diarrhea, abdominal distention, stomachache, vomiting, poor appetite, oliguria, correct dehydration and electrolyte disturbance etc.
To pour into the microcapsule (disaccharidase) that oral liquid is equipped with when it uses and stir evenly the back clothes in the medicinal liquid down.
Claims (11)
1, a kind of quick-acting antidiarrhea oral liquor for infant, feature is: its medicinal herb components that contains has: Polyporus, Rhizoma Atractylodis, Herba Pogostemonis, the Rhizoma Pinelliae, Fructus Hordei Germinatus, Dens Draconis, Fructus Rosae Laevigatae.
2, quick-acting antidiarrhea oral liquor for infant according to claim 1 is characterized in that: can add medicinal herb componentses such as Radix Paeoniae Rubra, Radix Bupleuri, Semen Plantaginis and Fructus Jujubae.
3, a kind of preparation method of quick-acting antidiarrhea oral liquor for infant, feature is:
A, be the solvent effective component extracting with water earlier to the Dens Draconis in the medicinal herb components of the present invention, Semen Plantaginis, add ethanol again and remove impurity such as destarching, protein, and be settled out inorganic salts-electrolyte, carry out quantitative analysis with ultraviolet spectra or thin layer chromatography, make potassium, sodium, chlorine, calcium ion content be equivalent to 1/3～1/2 " ORS ".
B, to the Fructus Hordei Germinatus in the medicinal herb components of the present invention, with water as solvent, add neutral salt, make range protein fractional precipitation, separation, remove the inorganic salts of volume in the enzyme liquid of saltouing through " dialysis " again, after extract conversion carbohydrase-disaccharidase, amylase, protease behind the concentrating under reduced pressure, lyophilization.
C, Polyporus, Radix Paeoniae Rubra, Fructus Rosae Laevigatae decocting are filtered effective component extracting, Rhizoma Atractylodis, the Rhizoma Pinelliae, Herba Pogostemonis, Radix Bupleuri water, steam distillation are extracted volatile oil, its filtrate mixed with the residual liquid of Polyporus, Radix Paeoniae Rubra, Fructus Rosae Laevigatae, Dens Draconis, Semen Plantaginis, Fructus Hordei Germinatus add volatile oil, electrolyte, sodium benzoate after concentrate adding ethanol, static certain hour, add an amount of distilled water again and arrange, through cold preservation, filter, be packaged in high temperature sterilize in the ampoule.
4, quick-acting antidiarrhea oral liquor for infant according to claim 1 and 2 and preparation method is characterized in that: can replace Polyporus by Poria in the medicinal herb components.
5, wean quick acting epidemic disease Ling oral liquid according to claim 1 and 2 and preparation method is characterized in that: can Cortex Magnoliae Officinalis replace Rhizoma Atractylodis in the medicinal herb components.
6, quick-acting antidiarrhea oral liquor for infant according to claim 1 and 2 and preparation method is characterized in that: can replace Herba Pogostemonis by Herba Eupatorii in the medicinal herb components.
7, quick-acting antidiarrhea oral liquor for infant according to claim 1 and 2 and preparation method is characterized in that: can replace Dens Draconis by Os Draconis in the medicinal herb components.
8, quick-acting antidiarrhea oral liquor for infant according to claim 1 and 2 and preparation method is characterized in that: can replace the Rhizoma Pinelliae by Succus Bambusae in the medicinal herb components.
9, quick-acting antidiarrhea oral liquor for infant according to claim 1 and 2 and preparation method is characterized in that: can Fructus Setariae Germinatus in the medicinal herb components, Fructus Crataegi replaces Fructus Hordei Germinatus.
10, quick-acting antidiarrhea oral liquor for infant according to claim 1 and 2 and preparation method is characterized in that: the Fructus Rosae Laevigatae in the medicinal herb components can Fructus Mume, catechu, Fructus Corni, Semen Lablab Album, Semen Euryales, Herba Euphorbiae Humifusae, Cortex Ziziphi spinosae Radicis, Fructus punicae granati skin replace.
11, according to described quick-acting antidiarrhea oral liquor for infant of claim 1-10 and preparation method, it is characterized in that: will go in the medicinal liquid with clothes with the disaccharidase microcapsule example that oral liquid is equipped with.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93101066A CN1057447C (en) | 1993-01-22 | 1993-01-22 | Quick-acting antidiarrhea oral liquor for infant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93101066A CN1057447C (en) | 1993-01-22 | 1993-01-22 | Quick-acting antidiarrhea oral liquor for infant and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1089853A true CN1089853A (en) | 1994-07-27 |
| CN1057447C CN1057447C (en) | 2000-10-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93101066A Expired - Fee Related CN1057447C (en) | 1993-01-22 | 1993-01-22 | Quick-acting antidiarrhea oral liquor for infant and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376255C (en) * | 2001-02-27 | 2008-03-26 | 韩国生命工学研究院 | Agastache rugosa extract and composition containing tilianin isolated and purified from said extract having anti-inflammatary activity and anti-atherogenic activity |
| CN102698127A (en) * | 2012-05-03 | 2012-10-03 | 谢京选 | Traditional Chinese medicine for treating infantile diarrhea |
| CN103110919A (en) * | 2013-02-26 | 2013-05-22 | 杨银兰 | Medicine for treating infantile diarrhea |
| CN105267492A (en) * | 2015-10-29 | 2016-01-27 | 赵卫国 | Anti-diarrhea traditional Chinese medicine decoction and preparation method thereof |
| CN111529658A (en) * | 2020-06-29 | 2020-08-14 | 山东中医药大学附属医院 | Ointment for treating rotavirus enteritis and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0246683A3 (en) * | 1986-05-13 | 1988-01-27 | Shell Internationale Researchmaatschappij B.V. | Process for the preparation of polymers |
-
1993
- 1993-01-22 CN CN93101066A patent/CN1057447C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376255C (en) * | 2001-02-27 | 2008-03-26 | 韩国生命工学研究院 | Agastache rugosa extract and composition containing tilianin isolated and purified from said extract having anti-inflammatary activity and anti-atherogenic activity |
| CN102698127A (en) * | 2012-05-03 | 2012-10-03 | 谢京选 | Traditional Chinese medicine for treating infantile diarrhea |
| CN103110919A (en) * | 2013-02-26 | 2013-05-22 | 杨银兰 | Medicine for treating infantile diarrhea |
| CN105267492A (en) * | 2015-10-29 | 2016-01-27 | 赵卫国 | Anti-diarrhea traditional Chinese medicine decoction and preparation method thereof |
| CN111529658A (en) * | 2020-06-29 | 2020-08-14 | 山东中医药大学附属医院 | Ointment for treating rotavirus enteritis and preparation method thereof |
| CN111529658B (en) * | 2020-06-29 | 2021-08-27 | 山东中医药大学附属医院 | Ointment for treating rotavirus enteritis and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1057447C (en) | 2000-10-18 |
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