CN115154546A - A Chinese medicinal composition and its preparation method - Google Patents
A Chinese medicinal composition and its preparation method Download PDFInfo
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- CN115154546A CN115154546A CN202210780155.6A CN202210780155A CN115154546A CN 115154546 A CN115154546 A CN 115154546A CN 202210780155 A CN202210780155 A CN 202210780155A CN 115154546 A CN115154546 A CN 115154546A
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses a traditional Chinese medicine composition, which comprises the following components in parts by weight: 8-18 parts of melastoma dodecandrum, 20-35 parts of rhodomyrtus tomentosa root, 25-45 parts of caulis spatholobi, 20-35 parts of radix cynanchi bungei, 10-20 parts of double-petal smelly jasmine, 2-12 parts of saururus chinensis, 15-35 parts of oldenlandia diffusa, 15-35 parts of houttuynia cordata, 15-35 parts of plantain herb, 10-20 parts of radix ophiopogonis, 10-20 parts of glossy privet fruit, 12-22 parts of semen cuscutae and 140-260 parts of lean meat. The invention also discloses a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the effects of tonifying primordial qi, regulating qi and blood, reinforcing kidney, nourishing yin, moistening dryness, promoting diuresis and expelling toxin, and can achieve the effect of treating both symptoms and root causes for treating diabetes and complications thereof.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a preparation method thereof.
Background
Diabetes mellitus is a metabolic disease basically characterized by long-term increase of blood glucose level caused by interaction of genetic and environmental factors, and the death rate of diabetes mellitus is second to cardiovascular and cerebrovascular diseases and various tumors, which is called the third-leading death.
At present, western medicines are mainly used for treating diabetes, the western medicines are highly dependent on the western medicines and even lifelong, and the western medicines are more contraindicated, so that the western medicines are easy to cause drug dependence and toxic and side effects after long-term administration, and the aging of insulin cells is extremely easy to accelerate to induce various complications. In the current diabetes treatment process, the prevention of the occurrence and development of diabetes complications becomes a key and difficult point for treating diabetes.
The treatment of diabetes should be comprehensive, with diet therapy as the main and physical exercise as the auxiliary. At present, along with the improvement of living standard of people, the consciousness of people on health care is gradually enhanced, the traditional Chinese medicine composition with the effect of treating diabetes is provided, and the traditional Chinese medicine composition has very important significance and meets the market demand of improving the life quality of diabetic patients.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a traditional Chinese medicine composition which has the effects of invigorating primordial qi, regulating qi and blood, reinforcing kidney and nourishing yin, nourishing yin and moistening dryness, and promoting diuresis and expelling toxin, and can achieve the effect of treating both symptoms and root causes for treating diabetes and complications thereof.
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition which comprises the following components in parts by weight: 8-18 parts of melastoma dodecandrum, 20-35 parts of rhodomyrtus tomentosa root, 25-45 parts of caulis spatholobi, 20-35 parts of radix cynanchi bungei, 10-20 parts of double-petal smelly jasmine, 2-12 parts of saururus chinensis, 15-35 parts of oldenlandia diffusa, 15-35 parts of houttuynia cordata, 15-35 parts of plantain herb, 10-20 parts of radix ophiopogonis, 10-20 parts of glossy privet fruit, 12-22 parts of semen cuscutae and 140-260 parts of lean meat.
As an improvement of the scheme, the paint comprises the following components in parts by weight: comprises the following components in parts by weight: 10-16 parts of melastoma dodecandrum, 20-30 parts of rhodomyrtus tomentosa root, 28-42 parts of caulis spatholobi, 20-30 parts of radix cynanchi wilfordii, 12-18 parts of stinkweed jasmine, 3-10 parts of saururus chinensis, 15-30 parts of oldenlandia diffusa, 15-30 parts of houttuynia cordata, 15-30 parts of plantain herb, 12-18 parts of radix ophiopogonis, 12-18 parts of glossy privet fruit, 15-20 parts of semen cuscutae and 150-250 parts of lean meat.
As an improvement of the scheme, the paint comprises the following components in parts by weight: 10-15 parts of melastoma dodecandrum, 25-30 parts of rhodomyrtus tomentosa root, 30-40 parts of caulis spatholobi, 25-30 parts of radix cynanchi wilfordii, 12-18 parts of stinkweed jasmine, 3-10 parts of saururus chinensis, 20-30 parts of oldenlandia diffusa, 20-30 parts of houttuynia cordata, 20-30 parts of plantain herb, 12-18 parts of radix ophiopogonis, 12-18 parts of glossy privet fruit, 15-20 parts of semen cuscutae and 150-250 parts of lean meat.
As an improvement of the scheme, the paint comprises the following components in parts by weight: 12 parts of melastoma dodecandrum, 28 parts of rhodomyrtus tomentosa root, 35 parts of caulis sinomenii, 28 parts of radix cynanchi atrati, 15 parts of odorous jasmine, 5 parts of saururus chinensis, 25 parts of spreading hedyotis herb, 25 parts of heartleaf houttuynia herb, 25 parts of plantain herb, 16 parts of dwarf lilyturf tuber, 15 parts of glossy privet fruit, 18g of south dodder seed and 200g of lean meat.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the steps of uniformly mixing the raw materials, decocting, removing residues, taking filtrate, concentrating, adding auxiliary materials and preparing the granules.
As an improvement of the scheme, the decoction comprises two times of decoction, and the filtrates after the two times of decoction are combined, and each time of decoction lasts for 2-4 hours.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the steps of steaming the lean meat, then crushing the steamed lean meat and other raw materials, uniformly mixing, adding auxiliary materials, and obtaining pills.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the steps of uniformly mixing the raw materials, decocting, removing residues, taking filtrate, concentrating, extracting with alcohol, concentrating again, and adding auxiliary materials to obtain the oral liquid.
As an improvement of the scheme, the decoction comprises three times of decoction, filtrate obtained after the three times of decoction is combined, the time of the first decoction is 2-3 hours, and the water addition amount is 10-15 times of that of each raw material; the time for the second decoction is 1.5 to 2.5 hours, and the water addition amount is 5 to 8 times of that of the raw materials; the time for the third decoction is 0.5 to 1.5 hours, and the water addition amount is 2 to 3 times of that of the raw materials.
As an improvement of the scheme, the traditional Chinese medicine composition is applied to the preparation of the medicine for treating diabetes.
The compositions are proportioned by weight, and can be increased or reduced according to corresponding proportions during production, for example, the weight can be increased or reduced in units of kilogram in large-scale production or tons in large-scale production, and the weight can be increased or reduced in units of milligram in small-scale production, but the proportion of the weight proportion of the raw materials among the compositions is unchanged.
The unit Chinese medicine composed above can also be replaced by appropriate Chinese medicine with the same drug property, and the medicinal effect of the replaced Chinese medicine preparation is unchanged.
The proportion of the weight proportion is obtained by scientific screening, and for special patients, such as severe or mild patients, obese patients or lean patients, the proportion of the components can be correspondingly adjusted, the increase or decrease is not more than 100 percent, and the drug effect is not changed.
The traditional Chinese medicine composition is prepared by extracting or processing traditional Chinese medicine raw materials consisting of the formula in other modes to prepare a medicine active substance, and then taking the substance as the raw material, adding a pharmaceutically acceptable carrier if necessary, and preparing according to a pharmacy conventional technology. The active substance can be obtained by respectively extracting the traditional Chinese medicine raw materials, or by jointly extracting the traditional Chinese medicine raw materials, or by other methods, such as: the active substances can be obtained by crushing, squeezing, calcining, grinding, sieving, percolating, extracting, water extracting, alcohol extracting, ester extracting, ketone extracting, chromatography and other methods, can be substances in an extract form, can be dry extracts or fluid extracts, and can be prepared into different concentrations according to different requirements of preparations.
The weight percentage of the active pharmaceutical ingredients in the traditional Chinese medicine composition in the preparation can be 0.1-99.9%, and the balance is pharmaceutically acceptable carriers.
The Chinese medicinal preparation can be any medicinal oral dosage form, and the dosage forms comprise: decoction, pill, powder, capsule, granule, tablet, unguent, medicated liquor, granule, syrup, liniment, etc. The preparation of the invention is preferably oral liquid, pills and granules.
The pharmacological effects of the traditional Chinese medicine raw materials are as follows:
1. melastoma dodecandrum lour: it is sweet, astringent and neutral in nature, and enters lung, spleen and liver meridians; has effects in promoting blood circulation, stopping bleeding, relieving swelling, dispelling blood stasis, and clearing away heat and toxic materials; can be used for treating hyperpyrexia, swelling and pain, sore throat, toothache, dysentery with red and white blood, jaundice, edema, dysmenorrhea, metrorrhagia, leukorrhagia, puerperal abdominal pain, carbuncle, swelling, sore, hemorrhoid, and snake bite.
2. Radix rhodomyrti: it has sweet and astringent taste and mild property, and has effects of nourishing blood, dredging collaterals, stopping bleeding and relieving pain. Can be used for treating chronic hepatitis, hernia, metrorrhagia, rheumatalgia, and lumbar muscle strain.
3. Xuefeng Teng, sweet in flavor and warm in nature, enters lung and spleen meridians. Has effects in promoting blood circulation, invigorating qi and blood, strengthening tendons and bones, and dredging channels and collaterals. Can be used for treating deficiency of both qi and blood, menoxenia, blood deficiency, amenorrhea, puerperal abdominal pain, various hemorrhage, rheumatalgia, traumatic injury, lumbar muscle strain, etc.
4. White back root: it is slightly bitter and astringent in taste and mild in nature; entering liver and spleen meridians; has effects of nourishing liver, promoting blood circulation, invigorating spleen, eliminating dampness, astringing, and relieving depletion. Can be used for treating chronic hepatitis, splenomegaly, enteritis, diarrhea, proctoptosis, metroptosis, leucorrhea, edema during pregnancy, etc.
5. Double-petal smelly jasmine: it is slightly bitter in taste and mild in nature. Has the effects of dispelling pathogenic wind, promoting diuresis, eliminating phlegm, relieving cough, promoting blood circulation, and relieving swelling. Can be used for treating rheumatic arthralgia, tinea pedis, edema, sprain, swelling and pain due to blood stasis, hemorrhoid, and proctoptosis.
6. Saururus chinensis: it is sweet, pungent and cold in nature; entering lung, spleen, stomach and bladder meridians; has effects in clearing away heat and toxic materials, promoting urination, relieving swelling, treating sore, and eliminating food stagnation; can be used for treating dysuresia, jaundice, dysentery, loempe, dribbling, odynuria, leucorrhea, urinary tract infection, and inflammatory edema; it can be used for treating pyocutaneous disease, pyogenic infection, and eczema by external application.
7. And (3) spreading hedyotis herb: it is also called Longtouzhu and Zhuzai Cao, and it is sweet in flavor and cold in nature and mainly enters liver, kidney and small intestine meridians. Has effects of relieving fever, removing toxic substance, promoting diuresis and treating stranguria, and can be used for treating carbuncle, suppurative sore, sore throat, venomous snake bite, stranguria with heat, and pain.
8. Heartleaf houttuynia herb: it is bitter in taste and slightly cold in nature, and enters lung, bladder and large intestine meridians. Has effects of clearing away heat and toxic materials, expelling pus, resolving carbuncle, promoting urination, and treating stranguria. It can be used for treating pyretic stranguria, pulmonary abscess, purulent vomiting, phlegm-heat cough and asthma, laryngopathy, dysentery, carbuncle, and sore. Compendium: carbuncle and swelling due to heat-clearing toxin, hemorrhoid and proctoptosis, wind-broken, 30145disease and sal ammoniac toxin elimination. The title of Mediterranean treaty: move water, attack hardness, remove miasma and relieve summer-heat. Treating snake venom, treating beriberi, ulcer and deep-rooted carbuncle, and removing blood stasis.
9. Plantain herb: it is sweet in taste and cold in nature, enters liver, kidney and bladder channels, and has the effects of clearing heat, promoting urination, eliminating phlegm, cooling blood and removing toxic substances. It can be used for treating stranguria due to heat-evil, pain in urination, edema, summer-heat, dampness, diarrhea, phlegm heat, cough, hematemesis, epistaxis, carbuncle, sore, and toxic swelling.
10. Radix ophiopogonis: it is sweet and slightly bitter in taste, slightly cold in nature, and enters heart, lung and stomach meridians. Has the effects of nourishing yin, promoting the production of body fluid, moistening lung and clearing away heart-fire. Can be used for treating dry cough due to lung noise, consumptive cough due to yin deficiency, pharyngitis, pharyngalgia, thirst due to body fluid consumption, internal heat, diabetes, vexation, insomnia, and constipation due to intestinal noise.
11. Glossy privet fruit: it is sweet, slightly bitter and cool in nature, and enters liver and kidney meridians. Has effects of nourishing yin, liver and kidney, improving eyesight, and blackening hair. Can be used for treating hepatic and renal yin deficiency, vertigo, tinnitus, soreness of waist and knees, gray hair, dim eyesight, diabetes, and hectic fever.
12. And (3) semen cuscutae: it is sweet, neutral and pungent in flavor, and enters liver, kidney and spleen meridians. Has the effects of tonifying liver and kidney, securing essence, reducing urination, preventing miscarriage, improving eyesight and stopping diarrhea. Can be used for treating deficiency of liver and kidney, soreness of waist and knees, sexual impotence, spermatorrhea, enuresis, frequent micturition, kidney essence deficiency, habitual abortion, fetal irritability, blurred vision, tinnitus, and diarrhea due to deficiency of spleen and kidney.
13. Lean meat: it is sweet in flavor and mild in nature. Has effects in promoting growth and development, tonifying blood, moistening intestine and stomach, promoting salivation, invigorating kidney qi, and removing toxic heat. It can be used for treating febrile disease, impairment of body fluid, diabetes, asthenia due to kidney deficiency, puerperal blood deficiency, dry cough, constipation, tonifying blood, nourishing yin, moistening dryness, nourishing liver and kidney, moistening skin, promoting urination, and quenching thirst.
The implementation of the invention has the following beneficial effects:
1. has obvious curative effect by combining multiple aspects. Yin deficiency is the primary and dryness-heat is the primary syndrome of the present invention. The caulis ventilaginis, the rhodomyrtus tomentosa root and the lean meat of the invention can tonify qi and blood, and have the efficacy of tonifying deficiency and strengthening body; white back root has the effects of nourishing liver, softening liver, invigorating spleen and eliminating dampness; flos Jasmini sambac and herba Melastomatis Dodecandri have effects of promoting blood circulation, dredging collaterals, and strengthening body constitution and tendons; mixing fructus Ligustri Lucidi, radix Ophiopogonis, and semen Cuscutae with lean meat for nourishing yin, promoting fluid production, and invigorating kidney qi; the heartleaf houttuynia herb and the dwarf lilyturf tuber clear heat, moisten lung, promote the secretion of saliva or body fluid and remove damp-heat in large intestine; herba Hedyotidis Diffusae, herba plantaginis, and rhizoma Saururi have effects of clearing away heat and toxic materials, inducing diuresis and relieving swelling. The invention has the functions of invigorating primordial qi, regulating qi and blood, reinforcing kidney, nourishing yin, moistening noise, promoting diuresis, expelling toxin, nourishing channels, balancing qi and yin and removing complications.
The traditional Chinese medicine composition can be used for treating diabetes, and has the effects of reducing blood sugar and reducing the dependence of a diabetic on medical insulin or other hypoglycemic drugs; and can be used for treating diabetic complications, such as renal failure, edema, and gangrene of lower limbs.
2. Has various dosage forms and convenient preparation. The Chinese medicinal composition can be prepared into various dosage forms, can be prepared into proper dosage forms according to different parts, different diseases and different crowds, and is convenient to use.
3. Safe use and high cure rate. Clinical practice proves that the invention has high comprehensive cure rate for treating diabetes.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail with reference to specific embodiments.
While the invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not to be limited to the disclosed embodiment, but on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims.
Example 1: oral liquid
The formula is as follows: 8 parts of melastoma dodecandrum lour, 20 parts of rhodomyrtus tomentosa root, 25 parts of caulis spatholobi, 20 parts of radix cynanchi bungei, 10 parts of double-petal osbeckia chinensis, 2 parts of saururus chinensis, 15 parts of oldenlandia diffusa, 15 parts of houttuynia cordata, 15 parts of plantain herb, 10 parts of radix ophiopogonis, 10 parts of glossy privet fruit, 12 parts of semen cuscutae and 140 parts of lean meat.
The preparation method comprises the following steps:
mixing the raw materials uniformly, adding water for decocting for three times, wherein the time for the first decoction is 2.5 hours, the water addition amount is 13 times of that of the raw materials, the time for the second decoction is 2 hours, the water addition amount is 6 times of that of the raw materials, the time for the third decoction is 1 hour, and the water addition amount is 2 times of that of the raw materials, combining decoction solutions, filtering, concentrating the filtrate to the relative density of 1.1-1.15 at 60 ℃, adding ethanol to the ethanol content of 60-65%, stirring uniformly, standing for 24 hours, filtering, recovering the ethanol from the filtrate to the relative density of 1.03-1.06 at 65 ℃, adding 0.8 part of sorbic acid, mixing uniformly, filtering, adding water to prepare 1000ml, filling and sealing, and sterilizing to obtain the traditional Chinese medicine.
Example 2: oral liquid
The formula is as follows: 18 parts of melastoma dodecandrum, 35 parts of rhodomyrtus tomentosa root, 45 parts of caulis sinomenii, 35 parts of radix cynanchi bungei, 20 parts of odorous jasmine, 12 parts of saururus chinensis, 35 parts of spreading hedyotis herb, 35 parts of houttuynia cordata, 35 parts of plantain herb, 20 parts of radix ophiopogonis, 20 parts of glossy privet fruit, 22 parts of semen cuscutae and 260 parts of lean meat.
The preparation method comprises the following steps:
mixing the raw materials uniformly, adding water for decocting for three times, wherein the time for the first decoction is 3 hours, the water addition amount is 14 times of that of the raw materials, the time for the second decoction is 2.5 hours, the water addition amount is 7 times of that of the raw materials, the time for the third decoction is 1 hour, and the water addition amount is 2 times of that of the raw materials, combining the decoctions, filtering, concentrating the filtrate to the relative density of 1.1-1.15 at 60 ℃, adding ethanol to the ethanol content of 60-65%, stirring uniformly, standing for 24 hours, filtering, recovering the ethanol from the filtrate to the relative density of 1.03-1.06 at 65 ℃, adding 1 part of sorbic acid, mixing uniformly, filtering, adding water to prepare 1000ml, filling and sealing, and sterilizing to obtain the traditional Chinese medicine.
Example 3: oral liquid
The formula is as follows: 10 parts of melastoma dodecandrum lour, 20 parts of rhodomyrtus tomentosa root, 28 parts of caulis spatholobi, 20 parts of radix cynanchi bungei, 12 parts of odorous jasmine, 3 parts of saururus chinensis, 15 parts of spreading hedyotis herb, 15 parts of heartleaf houttuynia herb, 15 parts of plantain herb, 12 parts of dwarf lilyturf tuber, 12 parts of glossy privet fruit, 15 parts of south dodder seed and 150 parts of lean meat.
The preparation method comprises the following steps:
mixing the raw materials uniformly, adding water for decocting for three times, wherein the time for the first decoction is 2.5 hours, the water addition amount is 13 times of that of the raw materials, the time for the second decoction is 2 hours, the water addition amount is 6 times of that of the raw materials, the time for the third decoction is 1 hour, and the water addition amount is 2 times of that of the raw materials, combining decoction solutions, filtering, concentrating the filtrate to the relative density of 1.1-1.15 at 60 ℃, adding ethanol to the ethanol content of 60-65%, stirring uniformly, standing for 24 hours, filtering, recovering the ethanol from the filtrate to the relative density of 1.03-1.06 at 65 ℃, adding 0.8 part of sorbic acid, mixing uniformly, filtering, adding water to prepare 1000ml, filling and sealing, and sterilizing to obtain the traditional Chinese medicine.
Example 4: oral liquid
The formula is as follows: 15 parts of melastoma dodecandrum, 30 parts of rhodomyrtus tomentosa root, 40 parts of caulis sinomenii, 30 parts of radix cynanchi bungei, 18 parts of odorous jasmine, 10 parts of saururus chinensis, 30 parts of spreading hedyotis herb, 30 parts of heartleaf houttuynia herb, 30 parts of plantain herb, 18 parts of dwarf lilyturf tuber, 18 parts of glossy privet fruit, 20 parts of south dodder seed and 250 parts of lean meat.
The preparation method comprises the following steps:
mixing the raw materials uniformly, adding water for decocting for three times, wherein the time for the first decoction is 3 hours, the water addition amount is 14 times of that of the raw materials, the time for the second decoction is 2.5 hours, the water addition amount is 7 times of that of the raw materials, the time for the third decoction is 1 hour, and the water addition amount is 2 times of that of the raw materials, combining the decoctions, filtering, concentrating the filtrate to the relative density of 1.1-1.15 at 60 ℃, adding ethanol to the ethanol content of 60-65%, stirring uniformly, standing for 24 hours, filtering, recovering the ethanol from the filtrate to the relative density of 1.03-1.06 at 65 ℃, adding 1 part of sorbic acid, mixing uniformly, filtering, adding water to prepare 1000ml, filling and sealing, and sterilizing to obtain the traditional Chinese medicine.
Example 5: oral liquid
The formula is as follows: 12 parts of melastoma dodecandrum, 28 parts of rhodomyrtus tomentosa root, 35 parts of caulis sinomenii, 28 parts of radix cynanchi atrati, 15 parts of odorous jasmine, 5 parts of saururus chinensis, 25 parts of spreading hedyotis herb, 25 parts of heartleaf houttuynia herb, 25 parts of plantain herb, 16 parts of dwarf lilyturf tuber, 15 parts of glossy privet fruit, 18 parts of south dodder seed and 200 parts of lean meat.
The preparation method comprises the following steps:
mixing the raw materials uniformly, adding water for decocting for three times, wherein the time for the first decoction is 2.5 hours, the water addition amount is 13 times of that of the raw materials, the time for the second decoction is 2 hours, the water addition amount is 6 times of that of the raw materials, the time for the third decoction is 1 hour, and the water addition amount is 2 times of that of the raw materials, combining decoction liquids, filtering, concentrating the filtrate to the relative density of 1.1-1.15 at 60 ℃, adding ethanol until the alcohol content is 60% -65%, stirring uniformly, standing for 24 hours, filtering, recovering the ethanol from the filtrate to the relative density of 1.03-1.06 at 65 ℃, adding 0.8 part of sorbic acid, mixing uniformly, filtering, adding water to prepare 1000ml, encapsulating, and sterilizing to obtain the traditional Chinese medicine.
Example 6: pill preparation
The formula is as follows: 8 parts of melastoma dodecandrum, 20 parts of rhodomyrtus tomentosa root, 25 parts of caulis sinomenii, 20 parts of radix cynanchi bungei, 10 parts of odorous jasmine, 2 parts of saururus chinensis, 15 parts of spreading hedyotis herb, 15 parts of heartleaf houttuynia herb, 15 parts of plantain herb, 10 parts of dwarf lilyturf tuber, 10 parts of glossy privet fruit, 12 parts of south dodder seed and 140 parts of lean meat.
The preparation method comprises the following steps:
steaming the lean meat, grinding the steamed lean meat and other raw materials into powder, sieving and mixing uniformly. Adding 100-120 parts of refined honey into every 100 parts of powder to obtain the product.
Example 7: pill preparation
The formula is as follows: 18 parts of melastoma dodecandrum, 35 parts of rhodomyrtus tomentosa root, 45 parts of caulis sinomenii, 35 parts of radix cynanchi bungei, 20 parts of odorous jasmine, 12 parts of saururus chinensis, 35 parts of spreading hedyotis herb, 35 parts of houttuynia cordata, 35 parts of plantain herb, 20 parts of radix ophiopogonis, 20 parts of glossy privet fruit, 22 parts of semen cuscutae and 260 parts of lean meat.
The preparation method comprises the following steps:
steaming the lean meat, grinding the steamed lean meat and the rest raw materials into powder, sieving and uniformly mixing. Adding 100-120 parts of refined honey into every 100 parts of powder to obtain the product.
Example 8: pill preparation
The formula is as follows: 10 parts of melastoma dodecandrum, 20 parts of rhodomyrtus tomentosa root, 28 parts of caulis sinomenii, 20 parts of radix cynanchi bungei, 12 parts of odorous jasmine, 3 parts of saururus chinensis, 15 parts of spreading hedyotis herb, 15 parts of heartleaf houttuynia herb, 15 parts of plantain herb, 12 parts of dwarf lilyturf tuber, 12 parts of glossy privet fruit, 15 parts of south dodder seed and 150 parts of lean meat.
The preparation method comprises the following steps:
steaming the lean meat, grinding the steamed lean meat and other raw materials into powder, sieving and mixing uniformly. Adding 100-120 parts of refined honey into every 100 parts of powder to obtain the product.
Example 9: pill preparation
The formula is as follows: 15 parts of melastoma dodecandrum lour, 30 parts of rhodomyrtus tomentosa lour root, 40 parts of caulis spatholobi, 30 parts of radix cynanchi bungei, 18 parts of double-petal osbeckia chinensis, 10 parts of saururus chinensis, 30 parts of oldenlandia diffusa, 30 parts of houttuynia cordata, 30 parts of plantain herb, 18 parts of radix ophiopogonis, 18 parts of glossy privet fruit, 20 parts of semen cuscutae and 250 parts of lean meat.
The preparation method comprises the following steps:
steaming the lean meat, grinding the steamed lean meat and the rest raw materials into powder, sieving and uniformly mixing. Adding 100-120 parts of refined honey into every 100 parts of powder to obtain the product.
Example 10: pill preparation
The formula is as follows: 12 parts of melastoma dodecandrum, 28 parts of rhodomyrtus tomentosa root, 35 parts of caulis sinomenii, 28 parts of radix cynanchi atrati, 15 parts of odorous jasmine, 5 parts of saururus chinensis, 25 parts of spreading hedyotis herb, 25 parts of heartleaf houttuynia herb, 25 parts of plantain herb, 16 parts of dwarf lilyturf tuber, 15 parts of glossy privet fruit, 18 parts of south dodder seed and 200 parts of lean meat.
The preparation method comprises the following steps:
steaming the lean meat, grinding the steamed lean meat and the rest raw materials into powder, sieving and uniformly mixing. Adding 100-120 parts of refined honey into every 100 parts of powder to obtain the product.
Example 11: granule electuary
The formula is as follows: 8 parts of melastoma dodecandrum, 20 parts of rhodomyrtus tomentosa root, 25 parts of caulis sinomenii, 20 parts of radix cynanchi bungei, 10 parts of odorous jasmine, 2 parts of saururus chinensis, 15 parts of spreading hedyotis herb, 15 parts of heartleaf houttuynia herb, 15 parts of plantain herb, 10 parts of dwarf lilyturf tuber, 10 parts of glossy privet fruit, 12 parts of south dodder seed and 140 parts of lean meat.
The preparation method comprises the following steps:
decocting the raw materials in water twice, each time for 2.5 hours, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of about 1.18-1.22 at 50 ℃, adding 40 parts of dextrin, uniformly mixing, granulating, drying, and subpackaging into 100g per bag to obtain the traditional Chinese medicine composition.
Example 12: granule electuary
The formula is as follows: 18 parts of melastoma dodecandrum lour, 35 parts of rhodomyrtus tomentosa lour root, 45 parts of caulis spatholobi, 35 parts of radix cynanchi bungei, 20 parts of double-petal osbeckia chinensis, 12 parts of saururus chinensis, 35 parts of oldenlandia diffusa, 35 parts of houttuynia cordata, 35 parts of plantain herb, 20 parts of radix ophiopogonis, 20 parts of glossy privet fruit, 22 parts of semen cuscutae and 260 parts of lean meat.
The preparation method comprises the following steps:
decocting the raw materials in water twice, each time for 3 hours, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of about 1.18-1.22 at 50 ℃, adding 50 parts of dextrin, uniformly mixing, granulating, drying, and subpackaging into 100g per bag to obtain the traditional Chinese medicine composition.
Example 13: granule
The formula is as follows: 10 parts of melastoma dodecandrum, 20 parts of rhodomyrtus tomentosa root, 28 parts of caulis sinomenii, 20 parts of radix cynanchi bungei, 12 parts of odorous jasmine, 3 parts of saururus chinensis, 15 parts of spreading hedyotis herb, 15 parts of heartleaf houttuynia herb, 15 parts of plantain herb, 12 parts of dwarf lilyturf tuber, 12 parts of glossy privet fruit, 15 parts of south dodder seed and 150 parts of lean meat.
The preparation method comprises the following steps:
decocting the raw materials in water twice, each time for 2.5 hours, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of about 1.18-1.22 at 50 ℃, adding 40 parts of dextrin, uniformly mixing, granulating, drying, and subpackaging into 100g per bag to obtain the traditional Chinese medicine composition.
Example 14: granule
The formula is as follows: 15 parts of melastoma dodecandrum, 30 parts of rhodomyrtus tomentosa root, 40 parts of caulis sinomenii, 30 parts of radix cynanchi bungei, 18 parts of odorous jasmine, 10 parts of saururus chinensis, 30 parts of spreading hedyotis herb, 30 parts of heartleaf houttuynia herb, 30 parts of plantain herb, 18 parts of dwarf lilyturf tuber, 18 parts of glossy privet fruit, 20 parts of south dodder seed and 250 parts of lean meat.
The preparation method comprises the following steps:
decocting the raw materials in water twice, each time for 3 hours, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.18-1.22 at 50 ℃, adding 45 parts of dextrin, uniformly mixing, preparing into granules, drying, and subpackaging into 100g per bag to obtain the traditional Chinese medicine.
Example 15: granule
The formula is as follows: 12 parts of melastoma dodecandrum lour, 28 parts of rhodomyrtus tomentosa lour root, 35 parts of caulis spatholobi, 28 parts of radix cynanchi atrati, 15 parts of odorous jasminum grandiflorum, 5 parts of saururus chinensis, 25 parts of spreading hedyotis herb, 25 parts of heartleaf houttuynia herb, 25 parts of plantain herb, 16 parts of dwarf lilyturf tuber, 15 parts of glossy privet fruit, 18 parts of south dodder seed and 200 parts of lean meat.
The preparation method comprises the following steps:
decocting the raw materials in water twice, each time for 2.5 hours, merging decoction, filtering, concentrating filtrate into clear paste with the relative density of 1.18-1.22 at 50 ℃, adding 42 parts of dextrin, uniformly mixing, preparing granules, drying, and subpackaging into 100g per bag to obtain the traditional Chinese medicine.
It should be noted that the lean meat used in the embodiment of the present invention is pork lean meat.
In order to show the treatment effect of the traditional Chinese medicine composition on diabetes, the inventor carries out relevant animal tests and clinical effect comparison research on the medicine.
Animal experiments: selecting SPF-grade mice 18-22 g, except mice of a blank control group, carrying out abdominal cavity injection on Alloxan (AXN) 150mg/kg after fasting for 24 hours, and selecting mice with blood sugar more than 11.1mmol/L as model mice after the seventh day.
The model mice were divided into 5 groups: the test is divided into 6 groups of 10 patients by a model control group, a diabetes drug group, 3 experimental groups with different dosages and a blank control group. The oral liquid 10mL/kg, 20mL/kg and 30mL/kg of the traditional Chinese medicine preparation of the embodiment 5 are respectively used for gastric lavage administration for 3 different dose groups, and the administration is carried out once a day for 7 days; the same dosage of normal saline is used for intragastric administration once a day for 7 days in the blank control group and the model control group; the diabetes drug group uses metformin 10mL/kg for intragastric administration once a day for 7 days. 1 hour after the last administration, blood was collected from the orbit of the mouse, and the blood glucose concentration was measured to observe the effect on the blood glucose level of the mouse. The test data are shown in the following table:
| group(s) | Blood glucose level 1 hour after last administration (mmol/L) |
| Blank control group | 5.5 |
| Model control group | 17.5 |
| Metformin hydrochloride | 7.5 |
| 10mL/kg example 5 | 7.2 |
| 20mL/kg example 5 | 6.8 |
| 30mL/kg example 5 | 6.7 |
The result proves that the traditional Chinese medicine composition has obvious effect of reducing hyperglycemia mouse epinephrine hyperglycemia of a alloxan model and has certain repairing effect on pancreatic tissue damage caused by alloxan.
Observation of clinical curative effect
The prescription of the invention is prepared by selecting traditional Chinese medicines, has high safety and no toxic or side effect. In clinical practice, the inventor does not find that the traditional Chinese medicine composition has adverse reaction and related side effect on patients by clinical treatment and observation on the patients. The invention has obvious curative effect on diabetes and high comprehensive effective rate.
The invention is used for observing the clinical curative effect of diabetes
According to the new diagnosis standard 1999WHO of diabetes, the disease of the symptoms listed in the guidance principle of clinical research of new Chinese medicine in 2002, the main detection index and the curative effect judgment standard, and the symptoms listed in the classification scale of diabetes symptoms, the diagnosis of I and II type diabetes is met by the judgment of clinical data, and the summary is as follows:
the evaluation standard of curative effect is as follows:
the effect is shown: after treatment, the symptoms basically disappear, fasting blood sugar is less than 7.2mmol/L (130 mg/dL), blood sugar is less than 8.3mmol/L (150 mg/dL) after 2 hours of meal, the total amount of urine sugar is less than 10.0g after 24 hours, or the total amount of blood sugar and urine sugar after 24 hours is reduced by more than 30 percent compared with the total amount before treatment.
The method has the following advantages: the symptoms are obviously improved after treatment, fasting blood sugar is less than 8.3mmol/L (150 mg/dL), blood sugar is less than 10.0mmol/L (180 mg/dL) after 2 hours of meal, the total urine sugar amount at 24 hours is less than 25.0g, or the total urine sugar amount at 24 hours is reduced by more than 10 percent compared with the total urine sugar amount before treatment.
And (4) invalidation: the symptoms are not obviously improved after treatment, and the blood sugar and urine sugar are reduced without meeting the standards.
The dosage and the usage are as follows: (1) oral liquid: the preparation is administered 2 times a day, 20ml each time, and after breakfast and supper; (2) pill preparation: 2 times a day, 4-6 granules each time, and is taken after breakfast and supper; (3) granule: it is administered 2 times a day, one packet each time, and after breakfast and supper.
The treatment time is as follows: 11 weeks is a course of treatment.
The principle of medication and treatment: for the diabetes patients who use medical insulin or other hypoglycemic drugs, the taking of the medical insulin or other hypoglycemic drugs cannot be stopped immediately when the traditional Chinese medicine composition is taken, because the body and the course of disease have a buffering receiving process for new drugs and must be replaced sequentially according to the disease condition until the traditional Chinese medicine composition takes effect, controls the course of disease and can stop taking other drugs. For patients with diabetes II and diabetes mellitus-like hyperglycemia, the traditional Chinese medicine composition can be directly taken. The Chinese medicinal composition can also be used for preventing diabetes.
Typical cases are:
1. the patients: li Sheng, sex: male, age: age 43
The diabetic patients are born half year ago and suffer from diabetes, and the detection is as follows: 8.30mmol/L of fasting blood sugar and urine protein + +, and western medicines are not taken before diagnosis. Clinical symptoms are as follows: occasionally, dizziness, restlessness, irritability, dry mouth and tongue, polyphagia, hunger, emaciation, yellow urine, frequent micturition and hypodynamia occur. The wiry and thready pulse, and a yellowish tongue coating. Diabetes is caused by yin deficiency with internal heat and kidney essence deficiency.
After taking the oral liquid of the embodiment 5 for 6 weeks, the fasting blood sugar value is detected to be reduced to 5.3mmol/L. Keeping the conventional dosage, stopping taking after a treatment course, detecting the blood sugar value to be 5.1mmol/L, and keeping all other indexes normal. After three years of return visit, all the test indexes are normal.
2. The patients: yellow birth, sex: male, age: age 47 years old
The diabetes patient suffers from diabetes in the yellow birth and two years ago, and the detection shows that: fasting blood glucose of 9.0mmol/L and urine protein +++, the blood glucose value is still high when the local people take 2 tablets per day of metformin for medical treatment before the diagnosis. Clinical symptoms are as follows: dizziness, vexation and irritability, emotional depression, dry mouth and tongue, yellow urine, constipation in stool, less obvious symptoms, weak body and frequent sense of weakness often appear. A wiry and thready pulse, a reddish tongue with a yellowish tongue center and a dull and lusterless complexion. Diabetes is manifested by yin deficiency with internal heat, liver qi stagnation, kidney essence deficiency and long-term accumulation.
After taking the oral liquid of the embodiment 5 for 4 weeks, the fasting blood sugar value is detected to be reduced to 5.8mmol/L. The patient was instructed to take the hypoglycemic agent metformin 1 tablet/day, while continuing to take the oral liquid of example 5 for 2 weeks, and the fasting blood glucose value was determined to be 5.5mmol/L. Continuously keeping the conventional dosage, stopping taking metformin which is a hypoglycemic agent, stopping taking the metformin after a treatment course, and detecting that the blood sugar value is 5.3mmol/L and all other indexes are normal. After two years of return visit, all the test indexes are normal, and the fasting blood glucose value is within 6.0 mmol/L.
3. The patients: lady plum, gender: female, age: age 62 years old
Patients have asked medical attention at many places in Guangdong province, the medical effect is repeated, the blood sugar value is unstable, the diagnosis is carried out before 2016 years, facial edema, light pressure on finger prints of both lower limbs, dry mouth, not much drinking, frequent micturition at night, tarnish face, dizziness, tinnitus, dry eyes, hypodynamia, soreness and weakness of waist and knees, loose stool, dim tongue quality, dark purple spots of veins, white and greasy tongue coating, deep, weak, thready and unsmooth pulse. Fasting blood glucose value 11.3mmol/L, urine protein + + + + +, haematurin ammonia 25mg/dl, creatinine 0.8mg/dl, blood pressure 170/92mm/Hg. The diagnosis refers to spleen-kidney yang deficiency, water-dampness retention, blood stasis, diabetes and renal hypofunction.
After taking the granule of this example 13 for 2 weeks, the fasting blood glucose level was found to decrease to 9.1mmol/L, and the symptoms were relieved. After the medicine is taken for 2 weeks, the fasting blood sugar value is reduced to 6.2mmol/L. The patient is prescribed to reduce the Western medicine for lowering blood sugar, and after the medicine is continuously taken for 7 weeks, edema and other symptoms disappear, the renal function is obviously improved, and the disease condition is stable. The detection shows that urine protein, blood sugar value and the like are recovered to be normal, and the number of the hypoglycemic drugs is reduced to 3 from that of 6 metformin which is originally taken every day. Continuously keeping the conventional dosage for one treatment course, and stopping taking the hypoglycemic agent. The disease condition is not repeated after the return visit in 2019, and the self-feeling is good.
4. The patients: liu Sheng, sex: male, age: age 65
Patient 7/month 5 visit 2017, self-reported: diabetes mellitus has suffered for 12 years, and has the disadvantages of self-conscious dizziness, blurred vision, palpitation, asthma, temporary aggravation, and poor sleep quality. The diagnosis in remote Hospital is that diabetes complicated with cardiovascular and cerebrovascular sclerosis and retinitis is hospitalized, and the hospital is discharged after relaxation, and the period is repeated repeatedly, bp8.5/4KPa, ECG shows insufficient blood supply for heart, fasting blood sugar 14.5mmol/L, and urine protein + + +. The patient routinely uses 18 units of insulin injection for maintenance therapy in the morning and evening.
After taking the pill of the embodiment 10 for 5 weeks, the prodrug is reduced until the symptoms such as light headedness disappear after only taking the pill of the embodiment 10 for one treatment course, the double pulse is thready, mild and powerful, and the vision is obviously improved. However, the daily insulin injection still needs 12 units in the morning and evening, the blood sugar is controlled to be between 6.0 and 7.1mmol/L, and the urine protein is reduced to be normal. The patient is prescribed a course of consolidation therapy. After two courses of treatment, the vision is obviously improved, the dizziness and other uncomfortable symptoms disappear, the dependence of all injections can not be reduced, 3 units of daily insulin injection is still needed for maintaining treatment in the morning and 6 units of daily insulin injection in the evening, but various complications are relieved. The patients were advised to continue taking the pill of this example 10, and were visited back in 2019 in 6 months without the occurrence of the above symptoms. Patients still need 3 units of maintenance treatment in the morning and evening by using insulin injection, and then are recommended to take 2 tablets/day of metformin instead of insulin injection. The patient can not take western medicines constantly, which is the reason that the patient has long illness time and the physical function can not be repaired.
The embodiments described above are intended to facilitate a person of ordinary skill in the art in understanding and using the invention. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.
Claims (10)
1. A traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 8-18 parts of melastoma dodecandrum lour, 20-35 parts of downy rosemyrtle root, 25-45 parts of caulis spatholobi, 20-35 parts of radix cynanchi bungei, 10-20 parts of double-petal osbeckia chinensis, 2-12 parts of saururus chinensis, 15-35 parts of oldenlandia diffusa, 15-35 parts of houttuynia cordata, 15-35 parts of plantain herb, 10-20 parts of radix ophiopogonis, 10-20 parts of glossy privet fruit, 12-22 parts of semen cuscutae and 140-260 parts of lean meat.
2. The traditional Chinese medicine composition of claim 1, which comprises the following components in parts by weight: 10-16 parts of melastoma dodecandrum, 20-30 parts of rhodomyrtus tomentosa root, 28-42 parts of caulis spatholobi, 20-30 parts of radix cynanchi wilfordii, 12-18 parts of stinkweed jasmine, 3-10 parts of saururus chinensis, 15-30 parts of oldenlandia diffusa, 15-30 parts of houttuynia cordata, 15-30 parts of plantain herb, 12-18 parts of radix ophiopogonis, 12-18 parts of glossy privet fruit, 15-20 parts of semen cuscutae and 150-250 parts of lean meat.
3. The traditional Chinese medicine composition of claim 1, which comprises the following components in parts by weight: 10-15 parts of melastoma dodecandrum, 25-30 parts of rhodomyrtus tomentosa root, 30-40 parts of caulis spatholobi, 25-30 parts of radix cynanchi wilfordii, 12-18 parts of stinkweed jasmine, 3-10 parts of saururus chinensis, 20-30 parts of oldenlandia diffusa, 20-30 parts of houttuynia cordata, 20-30 parts of plantain herb, 12-18 parts of radix ophiopogonis, 12-18 parts of glossy privet fruit, 15-20 parts of semen cuscutae and 150-250 parts of lean meat.
4. The traditional Chinese medicine composition of claim 1, which comprises the following components in parts by weight: 12 parts of melastoma dodecandrum, 28 parts of rhodomyrtus tomentosa root, 35 parts of caulis sinomenii, 28 parts of radix cynanchi atrati, 15 parts of odorous jasmine, 5 parts of saururus chinensis, 25 parts of spreading hedyotis herb, 25 parts of heartleaf houttuynia herb, 25 parts of plantain herb, 16 parts of dwarf lilyturf tuber, 15 parts of glossy privet fruit, 18g of south dodder seed and 200g of lean meat.
5. A process for preparing a Chinese medicinal composition as claimed in any one of claims 1 to 4, wherein the said raw materials are mixed, decocted, deslagged, filtered, concentrated, added with excipients and made into granules.
6. The preparation method of the traditional Chinese medicine composition according to claim 5, wherein the decoction is carried out twice, and filtrates obtained after twice decoction are combined, and each decoction is carried out for 2-4 h.
7. A method for preparing a Chinese medicinal composition as claimed in any one of claims 1-4, wherein the lean meat is steamed, and then pulverized with the rest materials, mixed well, and added with adjuvants to obtain pill.
8. A process for preparing a Chinese medicinal composition as claimed in any one of claims 1 to 4, wherein the oral liquid is prepared by mixing the said raw materials, decocting, removing the residue, collecting the filtrate, concentrating, extracting with ethanol, concentrating again, and adding adjuvants.
9. The preparation method of the traditional Chinese medicine composition according to claim 8, wherein the decoction is carried out for three times, the filtrates after the three times of decoction are combined, the time for the first decoction is 2-3 h, and the water addition amount is 10-15 times of that of the raw materials; the time for the second decoction is 1.5 to 2.5 hours, and the water addition amount is 5 to 8 times of that of the raw materials; the time for the third decoction is 0.5 to 1.5 hours, and the water addition amount is 2 to 3 times of that of the raw materials.
10. The use of the Chinese medicinal composition according to any one of claims 1 to 4 for the preparation of a medicament for the treatment of diabetes.
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| CN103656467A (en) * | 2012-09-05 | 2014-03-26 | 王海华 | Auxiliary treatment medicine for diabetes |
| CN105456660A (en) * | 2014-08-26 | 2016-04-06 | 陈刚 | Traditional Chinese medicine for treatment of diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656467A (en) * | 2012-09-05 | 2014-03-26 | 王海华 | Auxiliary treatment medicine for diabetes |
| CN105456660A (en) * | 2014-08-26 | 2016-04-06 | 陈刚 | Traditional Chinese medicine for treatment of diabetes |
Non-Patent Citations (1)
| Title |
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| 张建华等: "中西医结合治疗Ⅱ型糖尿病56例" * |
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