CN111135247A - Traditional Chinese medicine for treating stage IV diabetic nephropathy - Google Patents
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Abstract
The invention relates to a traditional Chinese medicine for treating stage IV diabetic nephropathy, which can effectively solve the problem of medication for treating stage IV diabetic nephropathy and adopts the technical scheme that the traditional Chinese medicine comprises the following components in parts by weight: 30-60g of hairyvein agrimony, 15-30g of cinnamon, 10-20g of raw bighead atractylodes rhizome, 10-20g of semen allii tuberosi, 10-20g of microcos paniculata, 10-20g of common bombax, 10-20g of saururus chinensis and 5-10g of raw liquorice, mixing the components, adding drinking water with the weight 10 times that of the mixed raw materials, soaking for 30 minutes, decocting with strong fire for boiling, decocting with slow fire for 30 minutes, and filtering to obtain a first filtrate; adding the dregs into drinking water which is 8 times of the weight of the mixed raw materials, boiling with strong fire, decocting with slow fire for 25 minutes, and filtering to obtain a second filtrate; the two filtrates are combined, and are decocted and concentrated to 500mL by medium fire, the traditional Chinese medicine composition has the advantages of rich raw materials, scientific and reasonable compatibility, easy production and preparation, convenient taking and good effect, has the effects of tonifying qi, warming yang, promoting diuresis and clearing heat, is effectively used for treating the diabetes mellitus nephropathy in the IV stage, and has huge economic and social benefits.
Description
Technical Field
The invention relates to a medicine, in particular to a traditional Chinese medicine for treating diabetic nephropathy in stage IV.
Background
Diabetic nephropathy (DKD) is a common microvascular complication of diabetes, is the leading cause of End-stage Renal Disease (ESRD), and is also one of the leading causes of death in Diabetic patients. The international diabetes consortium reports show that about 40% of end stage renal disease is developed from diabetic nephropathy. Epidemiological investigation results show that the incidence rate of diabetes of adults in China already exceeds 9.7 percent, and 20 to 25 percent of Chinese diabetic patients are complicated with diabetic nephropathy. Early stage of diabetic nephropathy is hidden, symptoms and signs are not obvious, most patients enter a stage IV characterized by continuous large amount of albuminuria when diagnosis is confirmed, the 24-hour urine albumin output is more than 300mg, edema and hypertension are often accompanied, and renal function is gradually reduced. Once the disease course enters this stage, the disease deterioration rate is increased significantly, and finally the disease progresses to end stage nephropathy. Therefore, stage IV diabetic nephropathy is a critical stage requiring effective intervention with drugs.
Diabetic nephropathy belongs to the categories of diabetes, kidney fatigue, kidney asthenia, edema, guan ge and the like in traditional Chinese medicine. Through a large amount of long-term clinical observation, the basic pathogenesis of most of IV-stage diabetic nephropathy in the traditional Chinese medicine is deficiency of spleen and kidney qi and yang deficiency and internal accumulation of damp-heat, and the traditional Chinese medicine is suitable for tonifying qi, warming yang, promoting diuresis and clearing heat. The selected medicine formula is formed by long-term repeated optimization on the basis of repeated verification of clinical curative effect, and can effectively delay, block and even reverse the progress of the state of illness of the diabetic nephropathy in the IV stage.
Currently, western medicine for treating stage IV diabetic nephropathy mainly aims at changing life style, controlling blood sugar and blood pressure, correcting lipid metabolism, resisting oxidative stress, improving microcirculation, applying Angiotensin Converting Enzyme Inhibitor (ACEI) or angiotensin II receptor Antagonist (ARB), etc., and the curative effect is not ideal. The current western medicine for treating stage IV diabetic nephropathy is still in an exploration stage, and an effective treatment method is lacked. Therefore, there is a need for effective therapeutic agents that can significantly delay, block, and even reverse the progression of disease without toxic side effects.
Disclosure of Invention
In view of the above situation, the present invention aims to provide a Chinese medicine for treating stage IV diabetic nephropathy, which can effectively solve the problem of medication for treating stage IV diabetic nephropathy.
The technical scheme of the invention is that the traditional Chinese medicine for treating stage IV diabetic nephropathy comprises the following components by weight: 30-60g of hairyvein agrimony, 15-30g of cinnamon, 10-20g of raw bighead atractylodes rhizome, 10-20g of semen allii tuberosi, 10-20g of microcos paniculata, 10-20g of common bombax, 10-20g of saururus chinensis and 5-10g of raw liquorice, mixing the components, adding drinking water with the weight 10 times that of the mixed raw materials, soaking for 30 minutes, decocting with strong fire for boiling, decocting with slow fire for 30 minutes, and filtering to obtain a first filtrate; adding the dregs into drinking water which is 8 times of the weight of the mixed raw materials, boiling with strong fire, decocting with slow fire for 25 minutes, and filtering to obtain a second filtrate; mixing the two filtrates, decocting with medium fire, and concentrating to 300-.
The invention has the advantages of rich raw materials, scientific and reasonable compatibility, easy production and preparation, convenient taking and good effect, has the efficacies of tonifying qi, warming yang, promoting diuresis and clearing heat, is effectively used for treating the diabetes mellitus nephropathy in the IV stage, develops a new approach of medicaments for treating the diabetes mellitus nephropathy in the IV stage, and has huge economic and social benefits.
Detailed Description
The following examples are provided to explain the present invention in detail.
Example 1
In specific implementation, the invention provides a traditional Chinese medicine for treating stage IV diabetic nephropathy, which is prepared from the following raw materials in parts by weight: 45g of hairyvein agrimony, 20g of cinnamon, 15g of raw bighead atractylodes rhizome, 15g of semen allii tuberosi, 15g of microcos paniculata, 15g of kapok, 15g of saururus chinensis and 5g of raw liquorice, mixing the components, adding 1450mL of drinking water, soaking for 30 minutes, decocting with strong fire for boiling, then decocting with slow fire for 30 minutes, and filtering to obtain a first filtrate; adding 1160mL of drinking water into the residue, boiling with strong fire, decocting with slow fire for 25 minutes, and filtering to obtain a second filtrate; mixing the two filtrates, decocting with medium fire, and concentrating to 400 mL.
Example 2
In specific implementation, the invention provides a traditional Chinese medicine for treating stage IV diabetic nephropathy, which is prepared from the following raw materials in parts by weight: 35g of hairyvein agrimony, 27g of cinnamon, 12g of raw bighead atractylodes rhizome, 18g of semen allii tuberosi, 12g of microcos paniculata, 18g of kapok, 12g of saururus chinensis and 8g of raw liquorice, mixing the components, adding drinking water with the weight being 10 times of that of the mixed raw materials, soaking for 30 minutes, decocting with strong fire for boiling, decocting with slow fire for 30 minutes, and filtering to obtain a first filtrate; adding the dregs into drinking water which is 8 times of the weight of the mixed raw materials, boiling with strong fire, decocting with slow fire for 25 minutes, and filtering to obtain a second filtrate; mixing the two filtrates, decocting with medium fire, and concentrating to 350 mL.
Example 3
In specific implementation, the invention provides a traditional Chinese medicine for treating stage IV diabetic nephropathy, which is prepared from the following raw materials in parts by weight: 55g of hairyvein agrimony, 17g of cinnamon, 18g of raw bighead atractylodes rhizome, 12g of semen allii tuberosi, 18g of microcos paniculata, 12g of kapok, 18g of saururus chinensis and 6g of raw liquorice, mixing the components, adding drinking water with the weight being 10 times of that of the mixed raw materials, soaking for 30 minutes, decocting with strong fire for boiling, decocting with slow fire for 30 minutes, and filtering to obtain a first filtrate; adding the dregs into drinking water which is 8 times of the weight of the mixed raw materials, boiling with strong fire, decocting with slow fire for 25 minutes, and filtering to obtain a second filtrate; mixing the two filtrates, decocting with medium fire, and concentrating to 450 mL.
In the above medicament, wherein: herba et Gemma Agrimoniae, bitter and astringent in taste, neutral in nature, heart and liver meridian entered, deficiency tonifying, toxic substance removing, astringent, hemostatic, dysentery stopping, and malaria preventing; cinnamon, pungent and sweet in flavor, large in nature and hot in nature, enters kidney, spleen, heart and liver channels, tonifies fire, strengthens yang, induces fire to enter primordial qi, dispels cold, relieves pain, and warms and dredges channels and collaterals; raw rhizoma atractylodis macrocephalae, bitter and sweet in taste, warm in nature, entering spleen and stomach channels, invigorating spleen and replenishing qi, eliminating dampness and promoting diuresis, arresting sweating and preventing miscarriage; semen allii tuberosi, pungent and sweet in flavor, warm in nature, entering liver and stomach channels, warming and nourishing liver and kidney, tonifying yang and securing essence; the microcos paniculata leaves are slightly sour in taste, cool in nature, enter spleen and stomach channels, clear heat and promote diuresis, and digest and resolve stagnation; kapok, sweet and light in flavor, cool in nature, enters large intestine channels, clears heat and promotes diuresis, and detoxifies; saururi herba, sweet and pungent in flavor, cold in nature, enters lung and bladder channels, induces diuresis to reduce edema, and clears away heat and toxic materials; raw licorice root, sweet in taste, neutral in nature, enters heart, lung, spleen and stomach channels, tonifies spleen and qi, clears heat and toxic materials, eliminates phlegm and stops cough, relieves spasm and pain, and harmonizes the medicines.
According to the compatibility principle of the traditional Chinese medicines and the reality of treating the diabetes mellitus nephropathy in the IV stage, the hairyvein agrimony tonifies qi and detoxifies, the cinnamon tonifies fire and strengthens yang, and the medicines are monarch medicines together; raw rhizoma atractylodis macrocephalae is used for tonifying qi and drying dampness, semen allii tuberosi is used for tonifying yang and securing essence, and is used as a ministerial drug; the microcos paniculata has the effects of clearing heat, promoting diuresis, removing dampness and removing toxicity, and the saururus chinensis has the effects of clearing heat, promoting diuresis and relieving swelling, and are used as adjuvant drugs; raw licorice root, radix Glycyrrhizae Praeparata, acts as a guiding drug to coordinate the effects of the other drugs in the recipe. The components support each other, so that the traditional Chinese medicine composition has the effects of tonifying qi, warming yang, promoting diuresis and clearing heat, is effectively used for treating the diabetic nephropathy in the IV stage, and obtains very good beneficial technical effects through experiments, and related data are as follows (taking example 1 as an example):
selection and diagnosis of cases
Case selection was performed according to the following criteria. The diabetes diagnosis standard refers to the standard established by the World Health Organization (WHO) in 1999 and the American Diabetes Association (ADA) in 2006, and the diabetes can be diagnosed as diabetes by meeting one of the following conditions: (1) has typical diabetes symptoms such as polydipsia, polyphagia, polyuria, unidentified weight loss and the like, and random blood sugar is more than or equal to 11.1mmol/L, or fasting blood sugar is more than or equal to 7.0mmol/L, or blood sugar is more than or equal to 11.1mmol/L after 75g of glucose is orally taken for 2 hours. (2) Without typical diabetic symptoms, repeated examinations of blood glucose to the above criteria are required on additional days. The diagnosis standard of the diabetic nephropathy in stage IV refers to the diabetic nephropathy staging standard of the "fifteen" planning teaching material "internal science of the Ministry of health: has definite diabetes history, the urine albumin output is more than 300mg in 24 hours, edema and hypertension are mostly accompanied, and the blood creatinine level is normal or increased (not more than 450 mu mol/L). The syndrome differentiation and classification of the traditional Chinese medicine belong to spleen and kidney qi deficiency and yang deficiency and damp-heat internal accumulation. One of the following conditions, although meeting the above criteria, is excluded from selection: (1) those with acute complications of diabetes; (2) those with other kidney disease or urinary system infections; (3) those with liver function abnormalities; (4) those with malignant tumors or autoimmune diseases; (5) pregnant or lactating women.
Second, treatment scheme
The control group is given with conventional western medicine treatment, wherein the conventional treatment comprises reasonable diet and proper exercise, subcutaneous injection of blood sugar reducing medicines such as insulin and/or oral glycoplax tablets and the like is carried out to control the blood sugar within a reasonable range, 1 time a day of oral atorvastatin calcium tablets is carried out, 10-20 mg of the oral atorvastatin calcium tablets are carried out each time to control blood fat, oral kallidinogenase enteric-coated tablets are carried out for 3 times a day, 120-240U of the oral atorvastatin calcium tablets are carried out each time to improve microcirculation, oral angiotensin II receptor Antagonist (ARB) irbesartan tablets are carried out for 1 time a day, 150-300 mg of the oral angiotensin II receptor Antagonist (ARB) are carried out each time to reduce the blood pressure to below 130/80mgHg so as to reduce proteinuria and protect kidney functions, if the blood pressure cannot reach the standard, calcium channel blocker, β receptor blocker and diuretic are suitably added, and the symptomatic treatment is carried out on the basis of the control group, traditional Chinese medicine decoction is taken for 2 times a day, 1 time in the morning and evening and 200mL of each time, the oral medicine decoction.
Thirdly, evaluation standard of curative effect
(1) The traditional Chinese medicine syndromes comprise lassitude and hypodynamia, food intake reduction, intolerance to cold and cold limbs, soreness and weakness of waist and knees, yellow and red urine and unsmooth stool, which are divided into four grades of no, light, medium and heavy according to the severity according to the guiding principle of clinical research of new traditional Chinese medicine, and the grades are respectively recorded in 0, 2, 4 and 6, and the integral changes of the syndromes before and after two groups of treatments are compared. (2) Urine albumin output and blood creatinine levels were measured 24 hours before and after the two groups of treatments, and changes before and after the two groups of treatments were compared. (3) Comparing the clinical comprehensive curative effects of the two groups, the effect is obvious: the traditional Chinese medicine syndrome integral is reduced by more than or equal to 50 percent, and the urinary albumin output in 24 hours is reduced by more than or equal to 50 percent; the method has the following advantages: the traditional Chinese medicine syndrome integral is reduced by 30-50%, and the urinary albumin output in 24 hours is reduced by 30-50%; and (4) invalidation: can not reach the effective standard. Total effective rate (number of effective cases + number of effective cases)/total number of cases × 100%.
Fourthly, statistical treatment
For 86 confirmed cases of stage IV diabetic nephropathy (syndrome of spleen-kidney qi deficiency and yang deficiency and damp-heat accumulation in traditional Chinese medicine), the cases were randomly divided into 43 cases of the invention group and the control group according to a simple randomization method. The invention is composed of 26 men and 17 women; age 51-67 years, mean (58.91 ± 6.25) years; the course of diabetes is 6-16 years, with the average (9.83 +/-1.31) year. 27 men and 16 women in the control group; the age is 50-66 years, and the average (59.34 +/-6.32) years; the course of diabetes is 6-17 years, with the average (9.84 + -1.29) year. The two groups of general data are compared, have no statistical difference (P is more than 0.05) and are comparable.
The experimental data is processed by SPSS 20.0 statistical software, and the counting data is x2And (5) checking, and counting data by adopting t-checking.
The traditional Chinese medicine syndrome integrals before and after two groups of treatments are compared with the syndrome integrals after the treatment of the invention group, and compared with the syndrome integrals before the treatment of the invention group and the syndrome integrals after the treatment of the contrast group, the invention group has extremely significant statistical difference (P is less than 0.01), which indicates that the invention group has better treatment effect for improving clinical syndrome, and the curative effect of the invention group is obviously better than that of the contrast group.
Table 1 two groups of the integrated comparisons of the syndrome of traditional Chinese medicine before and after treatment (score,
)
note: compared with the group of the present invention before treatment,△p is less than 0.01; compared with the control group after the treatment,△p is less than 0.01. Compared with the control group before the treatment,*P＞0.05。
comparison of urine albumin output and blood creatinine levels 24 hours before and after treatment in two groups compared with the urine albumin output and blood creatinine levels 24 hours after treatment in the group of the invention before treatment, the urine albumin output and the blood creatinine levels are both very significant statistical differences (P is less than 0.01); compared with the treatment group, the treatment group has significant statistical difference (P is less than 0.05). The invention is provided with better therapeutic action for reducing 24 hours urine albumin output and blood creatinine level, and the curative effect is obviously better than that of the control group.
TABLE 2 comparison of urine albumin output and serum creatinine levels 24 hours before and after treatment in the two groups
Note: compared with the group of the present invention before treatment,△p is less than 0.01; compared with the control group after the treatment,*p is less than 0.05. Compared with the control group before the treatment,#p is less than 0.05. Compared with the control group before the treatment,▲P＞0.05。
comparison of clinical comprehensive curative effects of two groups shows that the clinical effective rate of the invention group is very significant statistical difference (P is less than 0.01) compared with that of the control group, and the clinical comprehensive curative effect of the invention group is obviously superior to that of the control group.
TABLE 3 two groups of comparative examples of clinical comprehensive therapeutic effect (%)
Note: in comparison with the group of the present invention,△P＜0.01。
in addition to the above experiment in example 1, the clinical experiments in examples 2-3 all gave similar and comparable results, which are not listed here. No adverse reaction is found in the experiment, which shows that the medicine is safe and the curative effect is stable and reliable.
It is noted that the Chinese medicinal composition provided by the invention can be prepared into pills, powder, granules, tablets, capsules, oral liquid and the like according to actual conditions, and all belong to the protection scope of the invention.
Fifth, conclusion
The traditional Chinese medicine composition has a good treatment effect on the diabetic nephropathy in the IV stage, can obviously improve clinical symptoms, obviously reduce urine protein and blood creatinine, and has a curative effect obviously superior to that of the current western medicine therapy.
Claims (5)
1. The traditional Chinese medicine for treating stage IV diabetic nephropathy is characterized by comprising the following components in parts by weight: 30-60g of hairyvein agrimony, 15-30g of cinnamon, 10-20g of raw bighead atractylodes rhizome, 10-20g of semen allii tuberosi, 10-20g of microcos paniculata, 10-20g of common bombax, 10-20g of saururus chinensis and 5-10g of raw liquorice, mixing the components, adding drinking water with the weight 10 times that of the mixed raw materials, soaking for 30 minutes, decocting with strong fire for boiling, decocting with slow fire for 30 minutes, and filtering to obtain a first filtrate; adding the dregs into drinking water which is 8 times of the weight of the mixed raw materials, boiling with strong fire, decocting with slow fire for 25 minutes, and filtering to obtain a second filtrate; mixing the two filtrates, decocting with medium fire, and concentrating to 300-.
2. The traditional Chinese medicine for treating stage IV diabetic nephropathy according to claim 1, wherein the composition is prepared from the following raw materials by weight: 45g of hairyvein agrimony, 20g of cinnamon, 15g of raw bighead atractylodes rhizome, 15g of semen allii tuberosi, 15g of microcos paniculata, 15g of kapok, 15g of saururus chinensis and 5g of raw liquorice, mixing the components, adding 1450mL of drinking water, soaking for 30 minutes, decocting with strong fire for boiling, then decocting with slow fire for 30 minutes, and filtering to obtain a first filtrate; adding 1160mL of drinking water into the residue, boiling with strong fire, decocting with slow fire for 25 minutes, and filtering to obtain a second filtrate; mixing the two filtrates, decocting with medium fire, and concentrating to 400 mL.
3. The traditional Chinese medicine for treating stage IV diabetic nephropathy according to claim 1, wherein the composition is prepared from the following raw materials by weight: 35g of hairyvein agrimony, 27g of cinnamon, 12g of raw bighead atractylodes rhizome, 18g of semen allii tuberosi, 12g of microcos paniculata, 18g of kapok, 12g of saururus chinensis and 8g of raw liquorice, mixing the components, adding drinking water with the weight being 10 times of that of the mixed raw materials, soaking for 30 minutes, decocting with strong fire for boiling, decocting with slow fire for 30 minutes, and filtering to obtain a first filtrate; adding the dregs into drinking water which is 8 times of the weight of the mixed raw materials, boiling with strong fire, decocting with slow fire for 25 minutes, and filtering to obtain a second filtrate; mixing the two filtrates, decocting with medium fire, and concentrating to 350 mL.
4. The traditional Chinese medicine for treating stage IV diabetic nephropathy according to claim 1, wherein the composition is prepared from the following raw materials by weight: 55g of hairyvein agrimony, 17g of cinnamon, 18g of raw bighead atractylodes rhizome, 12g of semen allii tuberosi, 18g of microcos paniculata, 12g of kapok, 18g of saururus chinensis and 6g of raw liquorice, mixing the components, adding drinking water with the weight being 10 times of that of the mixed raw materials, soaking for 30 minutes, decocting with strong fire for boiling, decocting with slow fire for 30 minutes, and filtering to obtain a first filtrate; adding the dregs into drinking water which is 8 times of the weight of the mixed raw materials, boiling with strong fire, decocting with slow fire for 25 minutes, and filtering to obtain a second filtrate; mixing the two filtrates, decocting with medium fire, and concentrating to 450 mL.
5. The traditional Chinese medicine for treating stage IV diabetic nephropathy according to claim 1, wherein the traditional Chinese medicine is a pill, powder, granule, tablet, capsule or oral liquid.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111821402A (en) * | 2020-07-30 | 2020-10-27 | 海南医学院 | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof |
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| CN105497502A (en) * | 2014-09-23 | 2016-04-20 | 朱欣怡 | Traditional Chinese medicine composition for promoting diabetes rehabilitation |
| CN107412678A (en) * | 2017-08-05 | 2017-12-01 | 成都市飞龙水处理技术研究所 | A kind of new medicine composition for treating diabetes and preparation method thereof |
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| CN105497502A (en) * | 2014-09-23 | 2016-04-20 | 朱欣怡 | Traditional Chinese medicine composition for promoting diabetes rehabilitation |
| CN107412678A (en) * | 2017-08-05 | 2017-12-01 | 成都市飞龙水处理技术研究所 | A kind of new medicine composition for treating diabetes and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111821402A (en) * | 2020-07-30 | 2020-10-27 | 海南医学院 | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof |
| CN111821402B (en) * | 2020-07-30 | 2022-03-01 | 海南医学院 | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof |
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