CN108969678A - A kind of external medicine composition and preparation method thereof for treating chronic psoriasis - Google Patents
A kind of external medicine composition and preparation method thereof for treating chronic psoriasis Download PDFInfo
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Abstract
The invention belongs to field of medicaments, in particular to a kind of external medicine composition and preparation method thereof for treating chronic psoriasis, the drug composition is with radix euphorbiae lantu, the fruit of summer cypress, safflower, ox-hide, cavings are prepared, and effective component is based on volatile oil obtained by steam distillation, dosage form is preferred with cream form, the Chinese medicine composition cavings can promote the Transdermal absorption of other active ingredients from traditional Chinese medicinal, to play synergistic effect, have excellent therapy effect to psoriasis.
Description
Technical field
The invention belongs to the field of Chinese medicines, the external medicine composition of specifically a kind for the treatment of chronic psoriasis.
Background technique
Chronic psoriasis (psoriasis) is a kind of skin disease that clinic is common, disease incidence each age group and gender it
Between without significant difference.Its definite pathogenesis and the cause of disease are upper at present indefinite.It is now recognized that the cause of disease of the disease may include it is immune
Power dysfunction (such as immune imbalance, immune deficiency etc.) and systemic disease (such as endocrine system disease, dystrophia, chronic infection,
Heredity or acquired skin barrier function obstacle, environment, allergy, temperature and humidity change, at heart factor etc..
The onset of disease is erythema, inflammatory red papules, about chestnut grain beans, mung bean size, gradually expanding later or merging becomes
Brownish red patch, clear border around have inflammatory blush, and bottom infiltration is obvious, and surface covers the dry canescence of multilayer or silver
White scales, gently the scraper surface scales of skin that peel off, gradually leaks out the shinny semitransparent thin film of one layer of pale red, then strike off film, then goes out
Existing small blutpunkte, claims petechial hemorrhage phenomenon.White scales, shinny film and petechial hemorrhage are diagnosis, the weight of psoriasis (psoriasis)
Want feature, referred to as three signs.Skin lesion form puts drop-wise, and coin shape, map shape is band-like, ring-shaped, general hair, seborrhea
Sample, eczema sample, oyster is shelly-shaped, flat moss sample, chronic hypertrophic excipuliform etc..Psoriasis (psoriasis) normal recurrent exerbation, patient's self-induction
Itch, therefore often scratching causes skin injury to aggravate infection chance, increases treatment difficulty.The course of disease is generally sent to the beginning of spring and winter.
Point three phases (1) continuously emerges into shape phase new fash, and old fash constantly expands that scales of skin that peel off thickness inflammation is obvious, and gargalesthesia is significant, skin sensitivity
Property, which increases, may occur in which similar shape.(2) resting stage does not move back without new rash, old rash.(3) catagen inflammatory resolution, the scales of skin that peel off are reduced, and fash reduces
It flattens, surrounding light color occurs and swoons, and finally stays temporary hypopigmentation or calmness.
Modern medicine mainly uses oral antihistamines to the treatment of chronic psoriasis (psoriasis), and glucocorticoid resists
The local topicals glucocorticoids such as raw element, anti-infectious preparation, antipruritic, emollient etc..
Wherein antihistamine is clinically one of most common drug of allergic disease, is sent out by antagonizing histamine receptor
Anti-allergic effects are waved, inhibits blood vessel exudation, mitigates angioedema.Common antihistamine includes cetirizine, Loratadine etc..Sugar
Cortin has immunosupress, and anti-inflammatory, antiallergy multiple action is one of common psoriasis (psoriasis) therapeutic agent,
Such as dexamethasone, saccharic acid Mometasone, hydrocortisone etc. is dermatology's common drug, but due to there are drug withdrawal rebound phenomenon and
Other adverse reactions, clinic is it is not recommended that be used for a long time, therefore be limited to the application of chronic psoriasis (psoriasis).
Summary of the invention
The object of the present invention is to provide a kind of external medicine composition and its preparation sides that can effectively treat chronic psoriasis
Method.
A kind of external medicine composition for treating chronic psoriasis is at least made of following Chinese medicine of raw material；Radix euphorbiae lantu, it is red
Flower, cordyceps sinensis, the fruit of summer cypress, ox-hide, in addition, the raw material of the external medicine composition further includes paddy rice bran.
The external medicine composition is made of following traditional Chinese medicinal components counted by weight ratio: 50 ~ 300 weight of paddy rice bran
Part, 1~25 parts by weight of radix euphorbiae lantu, 3~30 parts by weight of safflower, 2~25 parts by weight of the fruit of summer cypress, 5~30 parts by weight of ox-hide.
Preferably, the external medicine composition is made of following traditional Chinese medicinal components counted by weight ratio: paddy rice bran 100
Parts by weight, 10 parts by weight of radix euphorbiae lantu, 15 parts by weight of safflower, 15 parts by weight of the fruit of summer cypress, 5 parts by weight of ox-hide.
Preferably, the external medicine composition is made of following traditional Chinese medicinal components counted by weight ratio: paddy rice bran 120
Parts by weight, 8 parts by weight of radix euphorbiae lantu, 20 parts by weight of safflower, 18 parts by weight of the fruit of summer cypress, 10 parts by weight of ox-hide.
Preferably, the external medicine composition is made of following traditional Chinese medicinal components counted by weight ratio: paddy rice bran 150
Parts by weight, 5 parts by weight of radix euphorbiae lantu, 10 parts by weight of safflower, 16 parts by weight of the fruit of summer cypress, 15 parts by weight of ox-hide.
Preferably, the external medicine composition is made of following traditional Chinese medicinal components counted by weight ratio: paddy rice bran 80
Parts by weight, 5 parts by weight of radix euphorbiae lantu, 16 parts by weight of safflower, 10 parts by weight of the fruit of summer cypress, 6 parts by weight of ox-hide.
The dosage form of the external medicine composition of above-mentioned treatment chronic psoriasis (psoriasis) is creme, emulsion, paste, powder
Agent, lotion, gelling agent, aerosol, preferably paste.
The present invention also provides a kind of preparation methods of external medicine composition for treating chronic psoriasis, including following step
It is rapid:
(1) radix euphorbiae lantu is weighed by weight ratio, safflower, cavings, the fruit of summer cypress crushes respectively, cross pharmacopeia and sieve No. 7 sieves, mixed
Medicinal material coarse powder；
It (2) is 53 in temperature after being added distilled water immersion 20 hours into medicinal material coarse powder obtained by step (1) according to solid-liquid ratio 1:10
DEG C, air pressure is that vacuum distillation 4 hours is carried out under 0.09Mpa, it is then spare with the condensed volatile oil of volatile oil extractor collection,
It is spare to retain saturated oil saturated aqueous solution；
(3) by the remaining medicinal material decocting liquid filtering removal dregs of a decoction of step (2), filtrate is centrifugated 15 minutes with 2000 revs/min, point
The medicinal extract that relative density is 1.5 is condensed into from supernatant；
(4) ox-hide is weighed by weight ratio, it is dry with burning, it is rolled into powder, pharmacopeia is crossed and sieves No. 9 sieves, it is spare to retain powder；
(5) weighing of volatile oil obtained by step (2) is taken, the beeswax of volatile oil weight 50%, the solid of volatile oil weight 50% are separately weighed
Paraffin, the glycerin monostearate of volatile oil weight 120%, the atoleine of volatile oil weight 240%, volatile oil weight 50%
Albolene, the Arlacel-80 of volatile oil weight 20% liquefy under 80 DEG C of water bath conditions, stir evenly as oily phase；
(6) weighing of medicinal extract obtained by step (3) is weighed, takes medicinal extract weight 500% from saturated oil saturated aqueous solution obtained by step (2)
Saturated oil saturated aqueous solution, separately take the Tween-80 of medicinal extract weight 10%, liquefy, stirred evenly as water under 80 DEG C of water bath conditions
Phase；
(7) while hot by step (4) resulting powder, step (5) gained oil is mutually and water phase obtained by step (6) mixes, using at a high speed
3000 revs/min of homogeneous dispersion machine emulsify 20 minutes to get cream form.
" solid-liquid ratio " described in technical solution of the present invention refers to the weight and the body of " liquid " as leaching liquor of solid " material "
Long-pending ratio, unit g:ml, as solid-liquid ratio 1:10 refers to that 10ml extracting solution is added in 1g medicinal material.Disclosed in technical solution of the present invention
Parameter area should be understood as covering wherein included any and all subranges, such as 5~25 parts by weight, it is considered that including
Minimum value 5 and 25(include endpoint) between any and all subranges.
Since Chinese medicine is several there are a medicine or even wants phenomenon of the same name more, description is made to be clear and complete, needs to refer to
Out: radix euphorbiae lantu described in technical solution of the present invention is the fresh of Isolated From Thymelaeaceae Species Chinese Stellera Root or dry root tuber.Nature and flavor with
It is channel tropism, pungent, mild-natured, toxic.Return liver, the spleen channel；Pharmacological action dissipating bind, desinsection, antibacterial, sluicing are by drink.Cure mainly oedema abdominal distension, trusted subordinate
Pain, hemorrhoid complicated by anal fistula malignant sore, scabies, hemostasis, anti-inflammatory, detumescence, the diseases such as psoriasis.Its crude drug source, processing, character identifies, physics and chemistry reflects
Not, usage and dosage is " in Pharmacopoeia of People's Republic of China (2010 editions) on the books.
Safflower described in technical solution of the present invention is the dry flower of compositae plant safflower.Summer flower from yellow to red when pick,
It dries in the shade or dries.It is nature and flavor and channel tropism acrid flavour, warm-natured.Converge to heart and liver channels.Pharmacological action blood circulation, the scattered stasis of blood relieve the pain.Cure mainly amenorrhoea,
Dysmenorrhea, stasis of blood, sore are swollen to be ached, beats the stasis of blood swell, arthralgia, paralysis due to windstroke, macular eruption being dark-purple, reducing blood pressure, eliminating inflammation
Disease promotes blood circulation, reconciles endocrine；Its crude drug source, processing, character identify, it is physical and chemical identify, usage and dosage " in
Magnificent people's republic's pharmacopeia (2010 editions) " in it is on the books.
The fruit of summer cypress described in technical solution of the present invention is the ripening fruits of chenopod summer cypress.Harvesting is planted when the fruit matures in the fall
Strain, is dried, and lays fruit, removes impurity；Nature and flavor are pungent, bitter, cold with channel tropism.Return kidney, bladder meridian；Pharmacological action clearing heat and promoting diuresis is dispelled
Wind is antipruritic；It cures mainly the puckery pain of urine, pruritus vulvae leukorrhagia, rubeola, eczema, pruitus, inducing diuresis to remove edema, the strong yin of antibacterial, strengthening the essence, antipruritic disappear
It swells, treats damp and hot skin or chill, there is different degrees of legal person's inhibiting effect to dermatophyte；Its crude drug source, processing, character
Identify, physics and chemistry identifies.Usage and dosage is at " in Pharmacopoeia of People's Republic of China (2010 editions) on the books "
Paddy rice bran described in technical solution of the present invention is cereal；Main ingredient is volatile oil, and millet decladding claims rice spermoderm；Nature and flavor with
Channel tropism is sweet, flat, nontoxic.Enter spleen, stomach；Pharmacological action is antipruritic relieve heat, anti-inflammatory clearing damp, anti-corrosive antibacterial, cutin is promoted to be formed.It is main
Subacute, the hypertrophic cutaneous damage of Zhiduo County's kind, eczema, the treatment of a variety of scytitis, edema, replenishing vitamins, supplement amino acid,
Reducing blood lipid and other effects；Its crude drug source, processing, character identifies, physics and chemistry identifies, usage and dosage is in " the People's Republic of China's medicine
Allusion quotation (2005 editions) " in it is on the books.
Ox-hide described in technical solution of the present invention is the drying skin of the animal kingdom；Nature and flavor are salty, mild-natured with channel tropism taste.Lung, bladder
Through；Pharmacological action inducing diuresis for removing edema, removing toxic substances.It cures mainly for oedema, ascites, oliguria, skin sore, malignant sore；Its crude drug source adds
Work, character identify, physics and chemistry identifies, usage and dosage is in " Nanjing University of Traditional Chinese Medicine's Chinese medicine dictionary, Shanghai science and technology (2006
Version) " in it is on the books.
Beneficial effects of the present invention: present invention utilizes safflower blood circulation, dissolving stasis to relieve the pain, diminishes inflammation；The fruit of summer cypress is clear
Hot dampness removing, dispelling wind and arresting itching, rubeola, eczema, relieving itching and eliminating swelling；Radix euphorbiae lantu resisting pathogenic microbes, immune system, anti-inflammatory, detumescence, desinsection,
Psoriasis effect；Ox-hide inducing diuresis for removing edema, removing toxic substances；Paddy rice bran (cavings oil) relieve heat is antipruritic, anti-inflammatory clearing damp, anti-corrosive antibacterial, for a variety of
Subacute, hypertrophic cutaneous damage, replenishing vitamins, amino acid, the treatment of a variety of scytitis, to chronic psoriasis (psoriasis)
Eczema has certain peculiar curative effect；Especially for the present invention during recipe improvement, discovery beyond expectation, cavings oil is to above-mentioned
Chinese medicine, which absorbs, has significant facilitation, can improve above-mentioned Chinese medicine and act on the specific treatment of chronic psoriasis (psoriasis).
Specific embodiment
The traditional Chinese medicine emulsifiable paste of chronic psoriasis (psoriasis) is treated in chronic psoriasis (psoriasis) traditional Chinese medicine emulsifiable paste and its preparation
Prescription is as follows:
| Component | Prescription 1 | 1 control group of prescription | Prescription 2 | 2 control group of prescription | Prescription 3 | 3 control group of prescription | Prescription 4 | 4 control group of prescription |
| Cavings | 200g | 0g | 300g | 0g | 250g | 0g | 150g | 0g |
| Radix euphorbiae lantu | 18g | 18g | 22g | 22g | 10g | 10g | 5g | 5g |
| Safflower | 20g | 20g | 25g | 25g | 20g | 20g | 16g | 16g |
| The fruit of summer cypress | 25g | 25g | 28g | 28g | 25g | 25g | 10g | 10g |
| Ox-hide | 20g | 20g | 30g | 30g | 15g | 15g | 6g | 6g |
The preparation method of the above prescription Traditional Chinese medicine composition paste, comprising the following steps:
(1) radix euphorbiae lantu is weighed by weight ratio, safflower, cavings, the fruit of summer cypress crushes respectively, cross pharmacopeia and sieve No. 7 sieves, mixed
Medicinal material coarse powder；
It (2) is 53 in temperature after being added distilled water immersion 20 hours into medicinal material coarse powder obtained by step (1) according to solid-liquid ratio 1:10
DEG C, air pressure is that vacuum distillation 4 hours is carried out under 0.09Mpa, it is then spare with the condensed volatile oil of volatile oil extractor collection,
It is spare to retain saturated oil saturated aqueous solution；
(3) by the remaining medicinal material decocting liquid filtering removal dregs of a decoction of step (2), filtrate is centrifugated 15 minutes with 2000 revs/min, point
The medicinal extract that relative density is 1.5 is condensed into from supernatant；
(4) ox-hide is weighed by weight ratio, it is dry with burning, it is rolled into powder, pharmacopeia is crossed and sieves No. 9 sieves, it is spare to retain powder；
(5) weighing of volatile oil obtained by step (2) is taken, the beeswax of volatile oil weight 50%, the solid of volatile oil weight 50% are separately weighed
Paraffin, the glycerin monostearate of volatile oil weight 120%, the atoleine of volatile oil weight 240%, volatile oil weight 50%
Albolene, the Arlacel-80 of volatile oil weight 20% liquefy under 80 DEG C of water bath conditions, stir evenly as oily phase；
(6) weighing of medicinal extract obtained by step (3) is weighed, takes medicinal extract weight 500% from saturated oil saturated aqueous solution obtained by step (2)
Saturated oil saturated aqueous solution, separately take the Tween-80 of medicinal extract weight 10%, liquefy, stirred evenly as water under 80 DEG C of water bath conditions
Phase；
(7) while hot by step (4) resulting powder, step (5) gained oil is mutually and water phase obtained by step (6) mixes, using at a high speed
3000 revs/min of homogeneous dispersion machine emulsify 20 minutes to get cream form.
The effect of external medicine composition of the psoriasic chronic psoriasis for the treatment of of the present invention, is verified:
Experimental group setting: blank control group: distilled water 100ml
Chinese medicine composition high dose group: preparation such as prescription 2.
Chinese medicine composition middle dose group: preparation such as prescription 1 and prescription 3.
Chinese medicine composition low dose group: preparation such as prescription 4.
Each prescription control group: 1~4 control group of prescription.
Experimental subjects:, being randomly divided into 9 groups by Kunming mouse 54, and every group 6, male and female are unlimited, level-one, and weight 18~
22g。
Experimental procedure:
1. method of drawing material: dipping the cream form of each experimental group preparation respectively with cotton swab, smear rat-tail, 2 times a day, 14 times are one
The course for the treatment of, next day puts to death mouse after last is smeared, away from cutting at the 2cm of rat-tail root.In the case where avoiding damage to as far as possible, cut
Skin,
Cartilage is removed, a rectangle skin graft is taken to be attached on filter paper, puts into fixed in 10% formalin, conventional dehydration immediately,
Cedar oil is transparent, paraffin embedding, slice, the dyeing of hematoxylin eosin staining method.
2. measuring standard: measuring flake thickness one by one to each sample under an optical microscope and observe spinous layer and particle
Layer.Specific method: eyepiece micrometer is corrected with haemocytometer disk (plate), the lmm under 20 times of object lens is made to be equivalent to 50um.Use eyepiece
Micrometer measures basal layer of epidermis portion to cuticular layer bottom, that is, epidermis thickness (tail scale).Each skin graft continuously counts 10 squamas
Piece, each scale measure the thickness of scale epidermis at 10, obtain the total 100 tail scale epidermal thicknesses of the skin graft of every mouse
Numerical value, and find out every group of mouse tail scale epidermal thickness average value.
3. statistical procedures: each group epidermal thickness data with mean ± standard deviation (± S) it indicates.Data uses Dan Yin
Plain variance analysis is tested, and P>0.05 shows that there was no significant difference, and P<0.05 shows there is significant difference, and P<0.01 shows have
Significant differences.
Mouse tail scale horny layer of epidermis keratinocyte remains with nucleus under normal circumstances, and stratum granulosum granular cell
Missing, only has a small amount of granular cell, epidermis is relatively thin at hair follicle.Rat-tail scale because the normal angling of epidermis lacks stratum granulosum, therefore
The characteristics of analog psoriasis (psoriasis) parakeratosis.Drug as can promote rat-tail scale stratum granulosum formed, illustrate its may
The angling process for changing epidermis, is restored to normal angling from parakeratosis, it is thus possible to have treatment to psoriasis (psoriasis)
Effect.
Experimental result: the results are shown in Table 1, and 1~4 Chinese medicine composition of prescription, which smears mouse tail, apparent induction
Granulosa hyperplasia, the effect for thickening epidermis, especially prescription 2, prescription 1,3, high, middle dose group is to mouse tail scale epidermis particle
The facilitation that layer is formed is significant (P < 0.05), is better than each prescription control group: Chinese medicine composition low dose group: preparation such as prescription 4,
1~4 control group of prescription, after prescription 2, prescription 1,3 Chinese medicine compositions are smeared mouse tail 14 days in this experiment, hence it is evident that mouse can be promoted
Tail scale stratum granulosum is formed, and has therapeutic effect to psoriasis (psoriasis).
The variation of 1 mouse tail scale epidermal thickness (um) of table
By being tested above it can be found that cavings oil, which absorbs above-mentioned Chinese medicine, has significant facilitation, (prescription group is better than group
Square control group) specific treatment effect of the above-mentioned Chinese medicine to chronic psoriasis (psoriasis) can be improved.
Claims (7)
1. a kind of external medicine composition for treating chronic psoriasis, which is characterized in that the external medicine composition is by following
The traditional Chinese medicinal components counted by weight ratio are made: 50 ~ 300 parts by weight of paddy rice bran, 1~25 parts by weight of radix euphorbiae lantu, 3~30 weight of safflower
Part, 2~25 parts by weight of the fruit of summer cypress, 5~30 parts by weight of ox-hide.
2. a kind of external medicine composition for treating chronic psoriasis according to claim 1, which is characterized in that described outer
It is made with Chinese medicine composition of following traditional Chinese medicinal components counted by weight ratio: 100 parts by weight of paddy rice bran, 10 parts by weight of radix euphorbiae lantu,
15 parts by weight of safflower, 15 parts by weight of the fruit of summer cypress, 5 parts by weight of ox-hide.
3. a kind of external medicine composition for treating chronic psoriasis according to claim 1, which is characterized in that described outer
Be made with Chinese medicine composition of following traditional Chinese medicinal components counted by weight ratio: 120 parts by weight of paddy rice bran, 8 parts by weight of radix euphorbiae lantu are red
Spend 20 parts by weight, 18 parts by weight of the fruit of summer cypress, 10 parts by weight of ox-hide.
4. a kind of external medicine composition for treating chronic psoriasis according to claim 1, which is characterized in that described outer
Be made with Chinese medicine composition of following traditional Chinese medicinal components counted by weight ratio: 150 parts by weight of paddy rice bran, 5 parts by weight of radix euphorbiae lantu are red
Spend 10 parts by weight, 16 parts by weight of the fruit of summer cypress, 15 parts by weight of ox-hide.
5. a kind of external medicine composition for treating chronic psoriasis according to claim 1, which is characterized in that described outer
Be made with Chinese medicine composition of following traditional Chinese medicinal components counted by weight ratio: 80 parts by weight of paddy rice bran, 5 parts by weight of radix euphorbiae lantu are red
Spend 16 parts by weight, 10 parts by weight of the fruit of summer cypress, 6 parts by weight of ox-hide.
6. a kind of described in any item external medicine compositions for treating chronic psoriasis, feature exist according to claim 1~5
In the dosage form of the external medicine composition is creme, emulsion, paste, pulvis, lotion, gelling agent, aerosol.
7. a kind of described in any item preparation methods for the external medicine composition for treating chronic psoriasis of claim 1~7,
It is characterized in that, comprising the following steps:
(1) radix euphorbiae lantu is weighed by weight ratio, safflower, cavings, the fruit of summer cypress crushes respectively, cross pharmacopeia and sieve No. 7 sieves, mixed
Medicinal material coarse powder；
It (2) is 53 in temperature after being added distilled water immersion 20 hours into medicinal material coarse powder obtained by step (1) according to solid-liquid ratio 1:10
DEG C, air pressure is that vacuum distillation 4 hours is carried out under 0.09Mpa, it is then spare with the condensed volatile oil of volatile oil extractor collection,
It is spare to retain saturated oil saturated aqueous solution；
(3) by the remaining medicinal material decocting liquid filtering removal dregs of a decoction of step (2), filtrate is centrifugated 15 minutes with 2000 revs/min, point
The medicinal extract that relative density is 1.5 is condensed into from supernatant；
(4) ox-hide is weighed by weight ratio, it is dry with burning, it is rolled into powder, pharmacopeia is crossed and sieves No. 9 sieves, it is spare to retain powder；
(5) weighing of volatile oil obtained by step (2) is taken, the beeswax of volatile oil weight 50%, the solid of volatile oil weight 50% are separately weighed
Paraffin, the glycerin monostearate of volatile oil weight 120%, the atoleine of volatile oil weight 240%, volatile oil weight 50%
Albolene, the Arlacel-80 of volatile oil weight 20% liquefy under 80 DEG C of water bath conditions, stir evenly as oily phase；
(6) weighing of medicinal extract obtained by step (3) is weighed, takes medicinal extract weight 500% from saturated oil saturated aqueous solution obtained by step (2)
Saturated oil saturated aqueous solution, separately take the Tween-80 of medicinal extract weight 10%, liquefy, stirred evenly as water under 80 DEG C of water bath conditions
Phase；
(7) while hot by step (4) resulting powder, step (5) gained oil is mutually and water phase obtained by step (6) mixes, using at a high speed
3000 revs/min of homogeneous dispersion machine emulsify 20 minutes to get cream form.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623336A (en) * | 2008-07-08 | 2010-01-13 | 吴彦勇 | External liniment for treating psoriasis |
| CN102670801A (en) * | 2012-05-30 | 2012-09-19 | 方淼 | Traditional Chinese medicine external ointment for treating athlete's foot, tinea corporis and tinea manuum |
| CN105796690A (en) * | 2016-03-24 | 2016-07-27 | 甘肃东方天润玫瑰科技发展有限公司 | Rose traditional Chinese medicine composition for treating psoriasis and preparation method and application |
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2018
- 2018-10-11 CN CN201811180482.8A patent/CN108969678A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623336A (en) * | 2008-07-08 | 2010-01-13 | 吴彦勇 | External liniment for treating psoriasis |
| CN102670801A (en) * | 2012-05-30 | 2012-09-19 | 方淼 | Traditional Chinese medicine external ointment for treating athlete's foot, tinea corporis and tinea manuum |
| CN105796690A (en) * | 2016-03-24 | 2016-07-27 | 甘肃东方天润玫瑰科技发展有限公司 | Rose traditional Chinese medicine composition for treating psoriasis and preparation method and application |
Non-Patent Citations (2)
| Title |
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| 《中国家庭养生保健书库》编委会: "《中老年自我治病奇效方》", 31 August 2015, 上海科学普及出版社 * |
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