CN108969546A - A kind of preparation method of sundew plastics - Google Patents
A kind of preparation method of sundew plastics Download PDFInfo
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- CN108969546A CN108969546A CN201811159060.2A CN201811159060A CN108969546A CN 108969546 A CN108969546 A CN 108969546A CN 201811159060 A CN201811159060 A CN 201811159060A CN 108969546 A CN108969546 A CN 108969546A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention particularly discloses a kind of preparation methods of sundew plastics; it is by sundew extract 200g; borneol 30g, menthol 20g, dibutyl phthalate 30g; polyvinyl formal acetal 12.5g; acetone 100g and surplus are settled to 1000g by the ethyl alcohol of 75%v/v and are made, and external application plastics produced by the present invention, the used time is applied to affected part; film is formed after solvent volatilization to protect lesion face, while gradually release contained drug plays therapeutic effect.Preparation process is fairly simple, without material of mounting, and it is easy to use, plastics are applied to affected part, after plastics coating is dry, there is certain tear resistance in the film that affected part is formed, contained drug equilibrium can be made to absorb and generate curative effect.
Description
Technical field
The invention belongs to external drug preparation fields, and in particular to a kind of preparation method of sundew plastics.
Background technique
Eczema, neurodermatitis are more multiple skin diseases, due to epidermis part itch, bring pain to patient
It is bitter.It is often next difficult to treatment zone since the lesion of neurodermatitis is epidermis, it is extremely difficult to the effect of systemic therapy healing,
Some courses of disease severely impact the physical and mental health of patient for the several years.At present to cutaneous lesions such as neurodermatitis, eczemas,
External preparation is mostly used to carry out local treatment greatly, common preparation has tincture, aqua, ointment, paste, the various external applications such as lotion
Preparation is allowed to therapeutic effect and there is very big gap, some patients treat repeatedly through diversity, no since the medicament of use is different
The course of disease is only delayed, also increases the mental suffering of patient, returns patient and add financial burden.Research and develop a kind of good effect,
Short treating period and the preparation painful without treatment are purpose of the present invention places.According to national Chinese herbal medicine collect 1975 September the 1st edition,
The method introduced using sundew treatment eczema and neurodermatitis of page 513, this method is to take 100 grams of sundew powder, is dipped in
75% 1000 milliliters of alcohol.It filters after a week spare, smears affected part outside, it is 1-2 times daily.The applicant is using this method to eczema 10
Example, neurodermatitis 6 are treated, and effect is dissatisfied, and patient's its bad grasp of medical fluid dosage when smearing, medical fluid
It overflows, easily soaks the skin done harm to, the medical fluid residence time is short, has large effect to therapeutic effect.
Summary of the invention
In view of the above shortcomings, the present invention provides a kind of preparation methods of sundew plastics.
In order to realize the present invention, following technical method is specifically used:
A kind of preparation method of sundew plastics, which is characterized in that it is by sundew extract 200g, borneol 30g, peppermint
The ethyl alcohol that brain 20g, dibutyl phthalate 30g, polyvinyl formal acetal 12.5g, acetone 100g and surplus are 75%v/v
It is settled to 1000g to be made, the specific steps are as follows: take sundew coarse powder 100g, be placed in percolator, be 92%- with 5 times of amount concentration
After 95%v/v ethyl alcohol soaks 48h, by 0.8mlmin-1Speed diacolation, collect percolate 100g place it is spare, separately continue to collect
The percolate for continuing to collect is merged with pressed liquor through squeezing and is concentrated into 100g by percolate 100g, slag of filtering, and picks and places the infiltration purchased
Liquid of filtering merges with concentrate, obtains sundew extract 200g, borneol, menthol are added sequentially in sundew extract, stirred
Mix to molten, then be separately added into dibutyl phthalate and polyvinyl formal acetal be uniformly mixed it is spare；Separately by acetone
It mixes, is added in uniformly mixed reserve liquid with the 75%v/v ethyl alcohol of equivalent, then add 75%v/v ethyl alcohol and be settled to
1000g is stirred evenly, quantitative separating in vial to obtain the final product.
A kind of purposes of plastics of the invention as treatment neurodermatitis and eczema.
Medicinal material sundew in the present invention, alias: ground pepper, catchfly, shichongcao, pearl, flooring pearl, a gold
Pellet, fly net, lindera glauca grass etc..For Droseraceae drosera sundew Drosera peltata Smith
Var.Lunata(Buch.-Ham.) clarke [D.Lunata Ham.], with all herbal medicine.Nature,taste and action sweet, warm.It is toxic.It dispels
Wind is active, promoting blood circulation and stopping pain.Cure mainly traumatic injury, lumbar muscle strain, rheumatic arthritis, scrofula, eczema, neurodermatitis
Deng.Pharmacological action；Research has shown that the extract of sundew includes at least two kinds of naphthoquinone derivatives, has powerful spasmolysis.
Its chemical component: herb hydroxyl naphthoquinones (hydroxynaphthoqinone, C10H6O3), droserone (droserone,
C11H8O4), hydrogen cyanide etc..Trichome exudates contain the protein decomposition enzyme of similar pancreatin, and (national Chinese herbal medicine writes a group master
It compiles, " national Chinese herbal medicine compilation ", the first volume, September the 1st edition in 1975, page 513.).
Menthol, this product are a kind of cyclic alcohol of saturation obtained in peppermint oil dementholized.It is crystallized for colourless needles or prism-shaped
Or white crystalline powder, there is the characteristic perfume of peppermint.It is used as fragrant agent outside.This product have minimal irritation, nice and cool effect and
Local analgesia, itching-relieving action.
Borneol is colorless and transparent or white translucent the crisp crystallization of sheet；Gas faint scent, acrid flavour are cool.This product is in a medicament
As transdermal enhancer, the transmitance of cutaneous penetration drug can increase.
Beneficial effects of the present invention
External application plastics made from a kind of preparation method of plastics of the present invention, used time are applied to affected part, are formed after solvent volatilization thin
Film is to protect lesion face, while gradually release contained drug plays therapeutic effect.Preparation process is fairly simple, without material of mounting,
And it is easy to use, plastics are applied to affected part, after plastics coating is dry, there is certain tear-proof in the film that affected part is formed
Property, contained drug equilibrium can be made to absorb and generate curative effect.The present invention overcomes the solution after the contained soak medicine with ethyl alcohol of document
The deficiency of agent, the solvent of alcohol steep, mobility is big, and drug mobility is strong, and seepage area is easy greatly on the skin being seeped into, and
Clothing easy to pollute is made troubles to patient's use, since alcohol extracting solution part dose is small volatile, cannot keep lasting absorption
It utilizes, thus it is undesirable to the effect after using, and cure rate is low, cannot play normal effect of its contained drug well.Benefit
With plastics prepared by the present invention, the deficiencies in the prior art are not only overcome, while being presented in treatment eczema, neurodermatitis
Preferable application effect.It observes by clinic application, treats eczema 12 using plastics of the present invention, neurodermatitis 9, control
Treatment method is that medical fluid is applied to affected part, and being coated 1-2 times after medical fluid volatilization is dry makes into a tunic.It is 3-4 times daily.Average eczema
Medication 20 days, neurodermatitis medication 28 days, as a result eczema cured 9, improved 2, and invalid 1, total effective rate 91.6%；
Neurodermatitis cures 5, and 3 improvements, 1 invalid, total effective rate 88.8%.The plastics of the present invention from clinical application
Easy to use, dosage is small, and obtains preferable clinical therapeutic efficacy, and since plastics of the present invention are easy to use, patient is universal
Gladly receive, and cost is relatively low for drug price, alleviates the financial burden of patient, can show that plastics of the present invention have very well
Application prospect.
Shortcoming of the invention is that the main ingredient in its formula is that sundew, curative effect can't completely expire simply
Meaning, the present inventor further investigate it constantly, further find out more reasonable, more effective compatibility of drugs, constantly enhance
The effect of product, further develops the product of more preferable function times curative effect, benefits the skin disease of vast eczema and neurodermatitis
Patient.
Specific embodiment
Embodiment 1
Sundew extract 200g is weighed, borneol 30g is added, menthol 20g is stirred to dissolution, then is separately added into phthalic acid
Dibutyl ester 20g and polyvinyl formal acetal 12.5g is uniformly mixed spare；Acetone 100g is separately added to the 75%v/ of equivalent
The mixing of v ethyl alcohol, is added in uniformly mixed reserve liquid, and then adding 75%v/v ethyl alcohol makes into full dose to 1000g, sufficiently mixes
It closes uniformly, is sub-packed in the vial of 25ml, spiral cover seals to obtain the final product；The 200g sundew extract is by following methods system
: sundew powder 100g is weighed, is placed in percolator, after the alcohol dipping 48h that concentration is 92%v/v is measured with 5 times, is pressed
0.8ml·min-1Speed diacolation, collect percolate 100g place it is spare；Separately continue collect percolate 100g, slag of filtering through squeezing,
The percolate for continuing to collect is merged with pressed liquor and is concentrated into 100g, the percolate purchased is picked and placed and merges with concentrate, obtain thatch
Cream dish extract 200g.
Embodiment 2
Sundew extract 200g is weighed, borneol 30g is added, menthol 20g is stirred to dissolution, then is separately added into phthalic acid
Dibutyl ester 20g and polyvinyl formal acetal 12.5g is uniformly mixed spare；Acetone 100g is separately added to the 75%v/ of equivalent
The mixing of v ethyl alcohol, is added in uniformly mixed reserve liquid, and then adding 75%v/v ethyl alcohol makes into full dose to 1000g, sufficiently mixes
It closes uniformly, is sub-packed in the vial of 25ml, spiral cover seals to obtain the final product；The 200g sundew extract is by following methods system
: sundew powder 100g is weighed, is placed in percolator, after the alcohol dipping 48h that concentration is 93%v/v is measured with 5 times, is pressed
0.8ml·min-1Speed diacolation, collect percolate 100g place it is spare；Separately continue collect percolate 100g, slag of filtering through squeezing,
The percolate for continuing to collect is merged with pressed liquor and is concentrated into 100g, the percolate purchased is picked and placed and merges with concentrate, obtain thatch
Cream dish extract 200g.
Embodiment 3
Sundew extract 200g is weighed, borneol 30g is added, menthol 20g is stirred to dissolution, then is separately added into phthalic acid
Dibutyl ester 20g and polyvinyl formal acetal 12.5g is uniformly mixed spare；Acetone 100g is separately added to the 75%v/ of equivalent
The mixing of v ethyl alcohol, is added in uniformly mixed reserve liquid, and then adding 75%v/v ethyl alcohol makes into full dose to 1000g, sufficiently mixes
It closes uniformly, is sub-packed in the vial of 25ml, spiral cover seals to obtain the final product；The 200g sundew extract is by following methods system
: sundew powder 100g is weighed, is placed in percolator, after the alcohol dipping 48h that concentration is 95%v/v is measured with 5 times, is pressed
0.8ml·min-1Speed diacolation, collect percolate 100g place it is spare；Separately continue collect percolate 100g, slag of filtering through squeezing,
The percolate for continuing to collect is merged with pressed liquor and is concentrated into 100g, the percolate purchased is picked and placed and merges with concentrate, obtain thatch
Cream dish extract 200g.
Claims (2)
1. a kind of preparation method of sundew plastics, which is characterized in that it is the borneol 30g by sundew extract 200g, thin
The second that lotus brain 20g, dibutyl phthalate 30g, polyvinyl formal acetal 12.5g, acetone 100g and surplus are 75%v/v
Alcohol is settled to 1000g and is made, the specific steps are as follows: takes sundew coarse powder 100g, is placed in percolator, is with 5 times of amount concentration
After 92%-95%v/v ethyl alcohol soaks 48h, by 0.8mlmin-1Speed diacolation, collect percolate 100g place it is spare, it is another to continue
Percolate 100g is collected, the percolate for continuing to collect is merged with pressed liquor through squeezing and be concentrated into 100g by slag of filtering, and picks and places use of purchasing
Percolate merge with concentrate, obtain sundew extract 200g, borneol, menthol be added sequentially to sundew extract
In, stirring to molten, then be separately added into dibutyl phthalate and polyvinyl formal acetal be uniformly mixed it is spare；Separately will
Acetone is mixed with the 75%v/v ethyl alcohol of equivalent, is added in uniformly mixed reserve liquid, and 75%v/v ethyl alcohol constant volume is then added
To 1000g, stir evenly, quantitative separating in vial to obtain the final product.
2. purposes of a kind of sundew plastics as treatment neurodermatitis and eczema according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811159060.2A CN108969546A (en) | 2018-09-30 | 2018-09-30 | A kind of preparation method of sundew plastics |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811159060.2A CN108969546A (en) | 2018-09-30 | 2018-09-30 | A kind of preparation method of sundew plastics |
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| Publication Number | Publication Date |
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| CN108969546A true CN108969546A (en) | 2018-12-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811159060.2A Withdrawn CN108969546A (en) | 2018-09-30 | 2018-09-30 | A kind of preparation method of sundew plastics |
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- 2018-09-30 CN CN201811159060.2A patent/CN108969546A/en not_active Withdrawn
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Application publication date: 20181211 |
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