CN107551014B - Traditional Chinese medicine cataplasm for diminishing inflammation and relieving pain and preparation method thereof - Google Patents
Traditional Chinese medicine cataplasm for diminishing inflammation and relieving pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine cataplasm patch for diminishing inflammation and relieving pain and a preparation method thereof. The cataplasm patch consists of lining cloth, a paste body and an anti-sticking film, wherein the paste body comprises the following raw materials in parts by weight: 0.48-0.6 part of tartaric acid, 16-20 parts of water, 80-100 parts of a traditional Chinese medicine extract, 204-8 parts of tween, 70012-20 parts of sodium polyacrylate NP, 0.36-0.6 part of dihydroxyaluminum glycinate, 6.4-8.6 parts of azone and 40-50 parts of glycerol; the traditional Chinese medicine extract is prepared from the following medicinal materials in parts by weight: 20-30 parts of toddalia asiatica, 20-30 parts of elderberry, 30-50 parts of philippine flemingia root and 0.2-0.3 part of capsaicin. The traditional Chinese medicine cataplasm patch disclosed by the invention has a good curative effect on discomfort symptoms such as joint and muscle soreness, can be repeatedly torn off and pasted, has no pain, no residue, good moisture retention, comfortable use, no skin irritation and sensitization, is simple in manufacturing process, and has a good market prospect.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine cataplasm patch for diminishing inflammation and relieving pain and a preparation method thereof.
Background
With the development of the medical and health care industry of China, the life of people is continuously prolonged, the aging problem of the population is increasingly prominent, and accompanying osteoarthritis patients are more and more. Osteoarthritis (OA) is a chronic joint disease characterized by degenerative changes in the articular cartilage and secondary hyperosteogeny, most commonly seen in the elderly, where joint and muscle soreness is the most common symptom of OA and aggravates with the development of articular cartilage pathology. Common medicines for treating OA in western medicine are simple analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, glucosamine and the like. Although these drugs have a certain therapeutic effect on joint and muscle soreness, long-term application of these drugs can cause damage to the gastrointestinal tract digestive system, liver and kidney functions, etc. to different degrees. Therefore, it is important to select a treatment mode which is effective for a long time and has few adverse reactions.
The traditional Chinese medicine considers that joint and muscle ache is caused by invasion of exogenous pathogenic factors such as wind, cold and dampness, and the treatment focuses on dispelling wind and eliminating dampness. The traditional Chinese medicine external treatment method mainly comprises the application of external preparations such as traditional Chinese medicine liniment, powder, fumigation lotion, hot compress agent, tincture and the like. However, with the pace of social life increasing, the traditional external treatment methods have increasingly prominent problems, such as inconvenient topical application of powder; the medicines for fumigation, washing and wet dressing have good warm and hot effects, but the decocting steps are relatively complicated, and the compliance of patients is poor; scald is easy to occur when hot ironing medicine is used; the paste is easy to pollute clothes; the application time of the medicine is short, and adverse reactions such as skin allergy and the like are easy to occur. The cataplasm patch is a novel external preparation formulation, is supplemented with special traditional Chinese medicine extract, has the characteristics of easy carrying, low cost, strong moisture retention, good compatibility with skin, affinity and air permeability, is not easy to cause skin allergy, can be repeatedly used, can obviously improve the compliance of rehabilitation treatment to enhance the anti-inflammatory and analgesic effects especially for patients with chronic disease course, and has the advantage of drug slow release.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine cataplasm patch for diminishing inflammation and relieving pain and a preparation method thereof, wherein the traditional Chinese medicine cataplasm patch is a novel medicinal preparation prepared by taking Mintai medicinal materials as main raw materials and combining a modern traditional Chinese medicine cataplasm transdermal absorption technology, has the effects of warming and activating meridian, dispelling wind and removing dampness, and reducing swelling and relieving pain, and is suitable for treating symptoms such as swelling of joints and muscles, soreness and the like.
In order to achieve the purpose, the invention adopts the following technical scheme:
a Chinese medicinal cataplasma for relieving inflammation and pain comprises lining cloth (elastic cloth), ointment (containing medicinal extract, matrix and transdermal enhancer), and anti-adhesive film (isolation film on surface of ointment); the paste comprises the following raw materials in parts by weight: 0.48-0.6 part of tartaric acid, 16-20 parts of water, 80-100 parts of a traditional Chinese medicine extract, 204-8 parts of tween, 70012-20 parts of sodium polyacrylate NP, 0.36-0.6 part of dihydroxyaluminum glycinate, 6.4-8.6 parts of azone and 40-50 parts of glycerol; the traditional Chinese medicine extract is prepared from the following medicinal materials in parts by weight: 20-30 parts of toddalia asiatica, 20-30 parts of elderberry, 30-50 parts of philippine flemingia root and 0.2-0.3 part of capsaicin.
The preparation method of the traditional Chinese medicine cataplasm patch for diminishing inflammation and relieving pain comprises the following steps:
(1) weighing Toddalia asiatica, elderberry and Philippine flemingia root respectively, extracting for 2 times with 60-90 vol% ethanol solution 5-7 times the total weight of the medicinal materials, each time for 1h, filtering, combining filtrates, concentrating to remove the solvent, adding capsaicin, and stirring uniformly to obtain traditional Chinese medicine extract;
(2) adding tartaric acid and water into the Chinese medicinal extract, stirring for 15min, adding Tween 20, and stirring for 15min to obtain solution I;
(3) uniformly mixing sodium polyacrylate NP700, dihydroxyaluminum glycolate, azone and glycerol to obtain a solution II;
(4) and mixing the solution I and the solution II, uniformly stirring until the mixture is sticky, taking out the mixture in time, uniformly coating the mixture on a lining cloth, covering an anti-adhesion film, pressing and slicing to obtain the traditional Chinese medicine cataplasm for diminishing inflammation and relieving pain.
Toddalia asiatica, elderberry and Moghania philippinensis are medicinal and edible herbaceous plants with characteristics of Fujiatai. The invention utilizes three Chinese medicinal materials of asiatic toddalia root, elderberry and philippine flemingia root to prepare the cataplasm, takes the asiatic toddalia root as the monarch drug, promotes blood circulation, removes blood stasis, relieves pain, reduces swelling, dispels the wind and removes dampness; the elderberry is used as a minister, and the effects of dispelling wind and removing dampness, promoting blood circulation and relieving pain, and stimulating the menstrual flow and setting a bone are enhanced; the three medicines supplement each other to assist the philippine flemingia root, clear heat and remove toxicity, remove stasis and relieve swelling; the capsaicin with the warm and pungent natured powder has the effects of warming and activating channels, dispelling wind and removing dampness, and relieving swelling and pain.
Pharmacodynamic study:
1. analgesia experiment (mouse wriggling experiment)
1.1 grouping and intervention method
20 male Kunming mice with the weight of 18-22 g and the age of 1 month are taken, and are randomly divided into a blank control group, an inflammation diminishing and pain relieving babu patch group, a positive control group 1 (a cataplasm patch using philippine flemingia root alone), a positive control group 2 (a babble patch using philippine flemingia root and elderberry together), a positive control group 3 (a babble patch using philippine flemingia root and asiatic toddalia root together), a positive control group 4 (a babble patch using elderberry root and asiatic toddalia root together), and the mice are raised conventionally and the rejection area is 5cm2The hair on the back (after the rat hair is uniformly smeared on the back with a 10% sodium sulfide solution by a toothbrush, and is washed with clean water and wiped with gauze when the rat hair is in a yellow sticky liquid state, the experiment is carried out after 2 d).
Blank control group: no intervention is made; inflammation diminishing and pain relieving babu patch group, positive control group 1, positive control group 2, positive control group 3, positive control group 4: the area per administration was 5cm2The corresponding cataplasm patch (2.5 cm × 2.0 cm) is applied to the back skin with hair removed, and is applied for 12h each time, and the above groups are applied for 1 time every day for continuous 3d intervention.
1.2 detection index and method
The last dry prognosis is 30min, and each mouse is injected with 0.2ml of 0.6% acetic acid solution per mouse. And observing and recording the time of the mice first showing writhing reaction after the injection of the acetic acid solution and the times of the writhing reaction within 20min, counting the analgesic rates of the two groups before and after administration, and comparing the analgesic effects of the medicaments.
The analgesic rate = (average number of writhing of blank control group-average number of writhing of anti-inflammatory analgesic cataplasm patch group)/average number of writhing of blank control group x 100%.
1.3 results
After administration, compared with the blank control group and each positive control group, the times of writhing of the inflammation diminishing and pain relieving bab patch group are obviously reduced, and the difference has significant statistical significance (P < 0.05) (see table 1).
Table 1 results of the effect of anti-inflammatory analgesic traditional Chinese medicine cataplasma on glacial acetic acid induced chemical pain in mice (n =10,
±S）
2. anti-inflammatory assay (swelling of auricle assay)
2.1 grouping and intervention method
Taking 50 Kunming mice of 1 month age, male, with the weight of 18-22 g, grouping and intervening the mice according to the same method as 1.1, and removing the mice with the area of 1cm2The right ear hair (hair removal method 1.1).
Blank control group: no intervention is made; inflammation diminishing and pain relieving babu patch group, positive control group 1, positive control group 2, positive control group 3: the area per administration was 1cm2The corresponding cataplasma (1 cm × 1 cm) is applied to the skin of the right inner and outer ears without hair, each time for 12h, and the above components are respectively applied for 1 time and continuously for 6d at a fixed time every day.
2.2 detection index and method
After 30min of the last intervention, 0.05mL of xylene was applied to the two sides of the right ear of the mouse to cause inflammation, and the left ear was not applied to the control. 30min after inflammation, the mice are killed after neck removal, two ears are cut along the base line of auricles, round ear pieces of the two ears are cut by a puncher with the diameter of 8mm, the round ear pieces are immediately weighed by a ten-thousandth electronic analytical balance, the ear swelling degree and the swelling inhibition rate are calculated, and the anti-inflammatory effect of the medicaments is compared.
Swelling = weight of right ear of mice after inflammation-weight of left ear of mice after inflammation.
Swelling inhibition rate = (average degree of swelling of mouse left ear-average degree of swelling of mouse right ear)/average degree of swelling of mouse left ear × 100%.
2.3 results
(the swelling degree of auricle of mice in the cataplasma patch group with anti-inflammatory and analgesic effects is reduced after 30min of inflammation compared with the blank control group and each positive control group: (P<0.01) (see table 2).
Table 2 results of mouse ear swelling experiments (n =10,
±S）
2. clinical data:
the traditional Chinese medicine cataplasm patch disclosed by the invention is used for treating 60 cases of knee OA patients in the period from 1 month to 7 months in 2017, so that a remarkable clinical curative effect is obtained, and the clinical report is as follows:
1. general data
Of the 60 patients, 18 men and 42 women had a mean age (62.44. + -. 7.12) and a course (6.32. + -. 6.85) of years.
2. Diagnostic criteria
2.1 Western diagnostic standards
Refer to the "guidelines for diagnosis and treatment of osteoarthritis" 2007 edition of the Chinese medical society.
Firstly, knee joint pain is repeated in nearly 1 month;
the X-ray film (standing or weight bearing position) shows that the joint clearance is narrowed, subchondral bone sclerosis and/or cystic change and joint marginal osteophyte is formed;
③ the joint fluid is clear and sticky for at least 2 times, and WBC is less than 2000/ml;
fourthly, middle-aged and elderly patients (more than or equal to 40 years old);
morning stiffness is less than or equal to 30 min;
sixthly, bone rubbing sound is generated when the patient moves.
The formulation can be used for treating knee osteoarthritis.
2.2 Chinese medicine diagnostic Standard
Referring to the guiding principles of clinical research on new traditional Chinese medicines and the standard of curative effect of diagnosis of traditional Chinese medicine, the basic pathogenesis of patients with KOA is liver and kidney deficiency and wind-cold-dampness arthralgia, and the clinical manifestations are as follows:
soreness and weakness of the loins and knees, dull pain in joints, aggravated weather change, difficulty in flexion and extension of joints, preference for heat and aversion to cold, pale red tongue with thin, white or thick coating, and thready and wiry pulse.
3. Inclusion criteria
The patients who meet the diagnosis standard of the KOA and have symptoms of discomfort of joints and muscles and the like;
② the age is more than or equal to 40 years and less than or equal to 75 years;
third, the study can be understood and informed consent can be signed by the therapist, the patient himself or the legal guardian.
4. Exclusion criteria
Combining serious diseases of cardiovascular and cerebrovascular diseases, liver, lung, kidney, hemopoietic system and the like and psychopath;
② the skin is damaged seriously; patients in gestation and lactation;
and thirdly, patients who are allergic to the medicine cannot insist on treatment, add or subtract the medicine by self or receive other treatment at the same time, and influence observation and judgment of curative effect.
5. Standard of therapeutic effect
The curative effect is evaluated according to the standard of curative effect of diagnosis of traditional Chinese medicine diseases.
And (3) curing: after the medicine is taken, clinical symptoms such as swelling, aching pain and the like of the affected part basically or completely disappear;
the method has the following advantages: after the medicine is taken, the clinical symptoms of swelling, aching pain and the like of the affected part are obviously relieved;
and (4) invalidation: after a period of treatment, the symptoms are not improved;
total effective rate = (cure + effective)/total number of cases × 100%.
6. Using and using amount
After cleaning the affected part, the anti-sticking film on the surface of the medicinal cloth is uncovered, and the medicinal cloth is applied to the affected part and lightly spread and pressed by hand to enhance the bonding of the medicinal cloth and the skin.
The area and the number of the affected parts are adjusted according to the size of the affected part, and the patch is used for 12h or following the medical advice, and 7d is a treatment course.
7. Observation of therapeutic effects
After one treatment course, 20 cases are cured, 34 cases are effective, 6 cases are ineffective, the total effective rate is 90%, and no adverse reaction is caused.
Basic research and clinical practice show that the inflammation diminishing and pain relieving babu plaster can obviously relieve symptoms of swelling, aching pain and discomfort of joints and muscles of patients, has higher safety and effectiveness, is easy to carry, low in cost, strong in moisture retention, convenient and safe to use, and is suitable for popularization and application in clinical rehabilitation treatment of the aching pain of the joints and the muscles caused by OA.
Detailed Description
In order to make the present invention more comprehensible, the technical solutions of the present invention are further described below with reference to specific embodiments, but the present invention is not limited thereto.
Example 1
(1) Respectively weighing 25 parts by weight of toddalia asiatica, 25 parts by weight of elderberry and 30 parts by weight of philippine flemingia root, extracting for 2 times with a 60vol% ethanol solution 7 times the total weight of the medicinal materials for 1 hour each time, filtering, combining filtrates, concentrating to remove a solvent, adding 0.25 part by weight of capsaicin, and uniformly stirring to obtain a traditional Chinese medicine extract;
(2) weighing 0.48 part by weight of tartaric acid and 20 parts by weight of water, adding into 80 parts by weight of the traditional Chinese medicine extract, stirring for 15min, adding 4 parts by weight of tween 20, and stirring for 15min to obtain a solution I;
(3) uniformly mixing 12 parts by weight of sodium polyacrylate NP700, 0.36 part by weight of dihydroxyaluminum glycinate, 6.4 parts by weight of azone and 40 parts by weight of glycerol to obtain a solution II;
(4) and mixing the solution I and the solution II, uniformly stirring until the mixture is sticky, taking out the mixture in time, uniformly coating the mixture on a lining cloth, covering an anti-adhesion film, pressing and slicing to obtain the traditional Chinese medicine cataplasm for diminishing inflammation and relieving pain.
Example 2
(1) Respectively weighing 30 parts by weight of toddalia asiatica, 30 parts by weight of elderberry and 50 parts by weight of philippine flemingia root, extracting for 2 times with 90vol% ethanol solution 6 times of the total weight of the medicinal materials for 1 hour each time, filtering, combining filtrates, concentrating to remove a solvent, adding 0.3 part by weight of capsaicin, and stirring uniformly to obtain a traditional Chinese medicine extract;
(2) weighing 0.6 part by weight of tartaric acid and 18 parts by weight of water, adding into 100 parts by weight of the traditional Chinese medicine extract, stirring for 15min, adding 8 parts by weight of tween 20, and stirring for 15min to obtain a solution I;
(3) uniformly mixing 18 parts by weight of sodium polyacrylate NP700, 0.5 part by weight of dihydroxyaluminum glycinate, 7 parts by weight of azone and 50 parts by weight of glycerol to obtain a solution II;
(4) and mixing the solution I and the solution II, uniformly stirring until the mixture is sticky, taking out the mixture in time, uniformly coating the mixture on a lining cloth, covering an anti-adhesion film, pressing and slicing to obtain the traditional Chinese medicine cataplasm for diminishing inflammation and relieving pain.
The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.
Claims (1)
1. A traditional Chinese medicine cataplasm patch for diminishing inflammation and relieving pain comprises a lining cloth, an ointment body and an anti-sticking film, and is characterized in that: the paste comprises the following raw materials in parts by weight: 0.48-0.6 part of tartaric acid, 16-20 parts of water, 80-100 parts of a traditional Chinese medicine extract, 204-8 parts of tween, 70012-20 parts of sodium polyacrylate NP, 0.36-0.6 part of dihydroxyaluminum glycinate, 6.4-8.6 parts of azone and 40-50 parts of glycerol; the traditional Chinese medicine extract is prepared from the following medicinal materials in parts by weight: 20-30 parts of toddalia asiatica, 20-30 parts of elderberry, 30-50 parts of philippine flemingia root and 0.2-0.3 part of capsaicin;
the preparation method of the traditional Chinese medicine cataplasm patch for diminishing inflammation and relieving pain comprises the following steps:
(1) weighing Toddalia asiatica, elderberry and Philippine flemingia root respectively, extracting for 2 times with 60-90 vol% ethanol solution 5-7 times the total weight of the medicinal materials, each time for 1h, filtering, combining filtrates, concentrating to remove the solvent, adding capsaicin, and stirring uniformly to obtain traditional Chinese medicine extract;
(2) adding tartaric acid and water into the Chinese medicinal extract, stirring for 15min, adding Tween 20, and stirring for 15min to obtain solution I;
(3) uniformly mixing sodium polyacrylate NP700, dihydroxyaluminum glycolate, azone and glycerol to obtain a solution II;
(4) and mixing the solution I and the solution II, uniformly stirring until the solution I and the solution II are sticky, taking out the solution in time, uniformly coating the solution on a lining cloth, covering an anti-sticking film, pressing and slicing to obtain the traditional Chinese medicine cataplasm for diminishing inflammation and relieving pain.
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| CN108403813A (en) * | 2018-06-06 | 2018-08-17 | 海口市中医医院 | A kind of multitude's medicine preparation and preparation method thereof for treating the blood stasis type protrasion of the lumbar intervertebral disci |
| CN112043780A (en) * | 2020-10-27 | 2020-12-08 | 贵州黔草灵生物保健研发有限公司 | Anti-inflammatory analgesic golden bone patch |
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| JPH11209269A (en) * | 1998-01-16 | 1999-08-03 | Sekisui Chem Co Ltd | Cataplasm for external use |
| CN105596587A (en) * | 2015-12-31 | 2016-05-25 | 首都医科大学附属北京世纪坛医院 | Composition for relieving swelling and pain |
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