CN108938864A - A kind of application of Chinese medicine composition in the drug of preparation treatment herpesvirus infection associated diseases - Google Patents
A kind of application of Chinese medicine composition in the drug of preparation treatment herpesvirus infection associated diseases Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Abstract
The present invention relates to a kind of application of Chinese medicine composition in the drug of preparation treatment herpesvirus infection associated diseases, the Traditional Chinese medicine composition formula is as follows: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnoliae Officinalis, 120 parts by weight of the root of Dahurain angelica, 120 parts by weight of Poria cocos, 120 parts by weight of the shell of areca nut, 80 parts by weight of dried pinellia, 0.4 parts by volume of 10 parts by weight of extract of licorice root, 0.8 parts by volume of patchouli oil and perilla leaf oil.Chinese medicine composition of the invention uses traditional Chinese medicine for raw material, and toxic side effect is small, and treatment shingles zoster effect is obvious, and can prevent and treat postherpes neuralgia PHN.Either systemic administration or local application, effect are better than bleb common medicine acyclovir.Chinese medicine composition of the invention can shorten bleb cure time, and patient is allowed to walk out disease shade as early as possible, beneficial to the physical and mental health of patient.
Description
The invention belongs to field of medicaments, and in particular to a kind of Chinese medicine composition is in preparation treatment herpesviral associated diseases
Application in drug.
Background technique
Virus infected herpes (HerpesSimplex) are one kind by the virogenetic virus dermatopathy of virus infected herpes.Point
Herpes simplex and shingles zoster, wherein shingles zoster be by varicellazoster virus (varicella zoster virus,
VZV a kind of skin disease of acute herpetic caused by).VZV is a kind of common mankind a herpesviral, and form is in brick, outside
There is capsid coating in portion, and diameter is about 150-200nm, inside there is double-stranded DNA.VZV is there are two types of main protease: archaeal dna polymerase and
Thymidine kinase.Archaeal dna polymerase is that DNA synthesis institute is required, and the latter may be related with hiding for virus.Virus has very strong
Neural invasion, and people is its unique natural reservoir (of bird flu viruses).It can cause varicella in primary infection, this when, VZV was in different devices
It is bred in official, especially skin.After varicella recovery from illness, VZV can hide the neuromere of root, autonomic ganglia after spinal nerve
Equal positions.When lower for the resistance, tired, infection or flu, virus can be activated again, assemble new virus from nerve
In section, corresponding skin epidermis is reached along the nerve fibre of surrounding, causes the vesicle of segmental.It is propagated in spite of apparent
There is the report of viremia virusemia in path in the VZV activation of limitation, in skin bleb and the relevant pain of bleb,
The blister for being mainly characterized by having gathering shape of viral DNA shingles zoster in detectable peripheral blood mononuclear cells, generally along body
Zonal distribution is presented in body unilateral side peripheral nerve, can increase with significant nerve pain and regional nodes, this nerve dysmenorrhea
It can be often chronic.In addition, virus can transport to other positions by nerve, cause meningitis, vascular lesion, cranial nerve fiber crops disease and
Herpes zoster ophthalmicus etc..
Epidemiology tune Check data shows, shingles zoster and post-herpetic neuralgia (postherpetic
Neuralgia, PHN) disease incidence show the trend gradually increased.Post-herpetic neuralgia is herpes digitalis clinical healing
Pain lasts one month or more afterwards, about 20% Patients with Herpes Zoster had pain in report in 3 months after the onset,
15% patient report after morbidity 2 years has pain.Some researches show that post-herpetic neuralgia is close with the age
Correlation, with advancing age, the probability of morbidity are higher, and especially 60 years old or more patient morbidity is higher.There are some researches prove bands
After shape bleb patient recovery from illness, there is 9-19% patient to have post herpetic neuralgia.Due to the duration of pain, severity and treatment is arranged
The insensitivity applied, PHN cause huge harm to the body and mental health of patient, it is not only interfered, and patient's is normal
Social activities, can also be from causing patient that insomnia, loss of appetite occurs, and serious person even can develop into depression, serious shadow
Ring the quality of life of Patients with Herpes Zoster.
PHN there is no effective etiological treatment method, and treatment is mainly to promote based on repairing of neural injury and function adjust, medicine
Object treatment is most basic and most common method." Chinese pain medicine magazine " 2016.22 (3) disclose " refreshing after shingles zoster
Dysmenorrhoea diagnosis and treatment China Consensus of experts " combines European neurology in 2010 can alliance (European Federation of
Neurological Societies, EFNS), American Psychiatry disease association (American Academy of in 2004
Neurology, AAN) recommendation to PHN drug therapy, International Society of Pain (International in 2015
Association for the Study of Pain, IASP) the special interest group of neurogenic pain (NeuPSIG) is right
The recommendation of neurogenic pain drug therapy and the clinical evidence of different pharmaceutical, the first-line drug that PHN is treated in recommendation include
Agents of calcium ion channel modulators (Pregabalin and Gabapentin), tricyclic antidepressant (amitriptyline) and 5% lidocaine patch
Agent, Second line Drug include opioid drug and C16H25NO2.But said medicine each have certain adverse reaction, especially
It is dizzy, drowsiness etc..Therefore, it is good to develop a kind of shingles zoster effect for the treatment of, Small side effects especially can be treated effectively band-like
The demand of the drug of the post herpetic neuralgia of bleb is very urgent.
Granted patent CN103079574B discloses a kind of polyethylene glycol composition, and wherein polyethylene glycol can be separately as
Active constituent uses, and can also be used with other active components such as combination antiviral drugs, although the patent claims polyethylene glycol group
Herpes labialis, genital herpes and shingles zoster can be treated by closing object, but only describe polyethylene glycol combination in the description
Object treats the pharmacological evaluation of herpes labialis, and the pharmacological activity of shingles zoster can be treated by not disclosing the composition, and this field is public
Know, herpes labialis and shingles zoster are belonging respectively to two distinct types of virus infection.
Granted patent CN100341532C discloses a kind of external preparation for treating bleb, uses kuh-seng, propolis, tree peony
Skin, erigeron breviscapus extract prepare external preparation, but the external preparation not on the books is to post-herpetic neuralgia
Therapeutic effect how.
Summary of the invention
Herpesviral associated diseases are treated in preparation in view of this, the purpose of the present invention is to provide a kind of Chinese medicine compositions
Drug in application, Chinese medicine composition of the invention can treat rapidly shingles zoster and post herpetic neuralgia, and improve other
Clinical symptoms and shingles zoster adversely affect patient body, spiritual bring, curative for effect, easy to use, have wide
Market application prospect.
The formula of Chinese medicine composition of the invention is as follows: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnoliae Officinalis,
120 parts by weight of the root of Dahurain angelica, 120 parts by weight of Poria cocos, 120 parts by weight of the shell of areca nut, 80 parts by weight of dried pinellia, 10 parts by weight of extract of licorice root,
0.4 parts by volume of 0.8 parts by volume of patchouli oil and perilla leaf oil.
Such as without special specified, the unit of weight of the parts by weight in the traditional chinese medicine composition of the invention formula and the volume list of parts by volume
Position is matching relationship.That is: when the unit of weight of parts by weight is Kg, the volume unit of parts by volume is L；When the weight list of parts by weight
When position is g, the volume unit of parts by volume is mL.The preferred ginger Cortex Magnoliae Officinalis of Cortex Magnoliae Officinalis mentioned by the present invention.
The preparation method of Chinese medicine composition of the invention includes the following steps: to prepare above-mentioned Chinese medicine by formula ratio, rhizoma atractylodis,
Dried orange peel, the root of Dahurain angelica, Cortex Magnoliae Officinalis add 60% ethyl alcohol to extract, filtration, and filtrate is spare；Poria cocos, the shell of areca nut add water to cook, decocting liquid filtration, filtrate
It is spare；Dried pinellia is soaked in water, and after bubble to the saturating heart, is separately added 13.5 parts by weight of rhizoma zingiberis, is added water to cook, decocting liquid filtration, and filtrate is standby
With；Extract of licorice root is smashed rear boiling and is melted, filtration, and filtrate is spare；Merge above-mentioned filtrate；It is mixed that patchouli oil, perilla leaf oil is added
It is even.
Chinese medicine composition of the invention is for can directly give in the form of a solution, can also prepare as needed when treating
Any pharmaceutically acceptable dosage form.The pharmaceutically acceptable dosage form include Chinese medicine composition of the invention and it is optional a kind of or
A variety of pharmaceutically acceptable carriers, diluent or excipient and the addition of suitable step in above-mentioned preparation process.The present invention
Used term " pharmaceutically acceptable " refers to such compound, raw material, composition and/or dosage form, they are reasonable
In the range of medical judgment, be suitable for contacted with patient tissue and without excessive toxicity, irritation, allergy or with reasonable benefit
The symmetrical other problems of benefit/Hazard ratio and complication, and effective for given application.
Pharmaceutical preparation is suitable for being administered by any suitable approach, for example, by take orally (including oral cavity or sublingual), rectum,
Nose, part (including oral cavity, sublingual or percutaneous), vagina or parenteral (including subcutaneous, intradermal, intramuscular, intra-articular, intrasynovial, chest
Bone is interior, intrathecal, intralesional, intravenous or intradermal injection or infusion) approach.It can be by any known method of art of pharmacy
This kind of preparation is prepared, such as by mixing active constituent with carrier or excipient.It is preferred that oral administration, local administration or injection
Administration.
Pharmaceutical preparation suitable for oral administration is provided by independent unit, such as the solution in aqueous or non-aqueous liquid
Or suspension；Capsule or tablet；Powder or granule；Edible foam formulations or foaming preparations etc..
For example, for oral administration in the form of a tablet or capsule, active medicine component can with can pharmaceutically connect
The oral, non-toxic inert carrier (such as ethyl alcohol, glycerol, water etc.) received mixes.By the way that compound powder is broken into suitable fine ruler
It is very little, and mix with the pharmaceutical carrier (such as the edible carbohydrate such as starch or mannitol) equally crushed to prepare powder.Also
Corrigent, preservative, dispersing agent and colorant may be present.
It by preparing pulverulent mixture as described above, and is loaded into the gelatin shell of forming, to prepare capsule.It is filling
It fills out before operation, it can be by glidant and lubricant (such as colloidal silicon dioxide, talcum powder, magnesium stearate, calcium stearate or solid-state
Polyethylene glycol) it is added in pulverulent mixture.Can also be added when taking capsule by improve drug utilizability disintegrating agent or
Solubilizer (such as agar, calcium carbonate or sodium carbonate).
When furthermore needing or is required, suitable adhesive, lubricant, disintegrating agent and colorant can also be mixed mixture
In.Suitable adhesive includes starch, gelatin, natural sugar (such as glucose or beta lactose), corn sweetener, natural and synthesis
Gummy (such as gum arabic, tragacanth or mosanom), carboxymethyl cellulose, polyethylene glycol etc..For these dosage forms
Lubricant includes enuatrol, sodium chloride etc..Disintegrating agent includes but is not limited to starch, methylcellulose, agar, bentonite, xanthan
Glue etc..For example, lubricant and disintegrating agent is added by the way that pulverulent mixture, granulation or pre- tabletting is made, and it is tabletted, to make
At tablet.By the compound suitably crushed and diluent as described above or base-material, optionally with adhesive, (such as carboxymethyl is fine
Tie up element, alginates, gelatin or polyvinylpyrrolidone), dissolve inhibitor (such as paraffin), absorbsion accelerator (quaternary salt) and/or
Absorbent (such as bentonite, kaolin or Dicalcium Phosphate) mixing, to prepare pulverulent mixture.Useful binders (such as syrup, shallow lake
Slurry, mucialga of arabic gummy or cellulosic material or polymeric material solution) wetting after pressurize sieving, pulverulent mixture is pelletized.System
One alternative of grain is can be made by pulverulent mixture by tablet press machine the result is that will form bad agglomerate and smash again
Particle.Can be by the way that stearic acid, stearate be added, talcum powder or mineral oil make particle lubrication to prevent from adhering to the punch die of tablet press machine
On.Then the mixture through lubricating is tabletted.The compound of the content of present invention can also be mixed with the inert carrier of free-flowing
It closes, it can be tabletted without passing through granulation or pre- tableting step.It can provide transparent or opaque by shellac seal coat, sugar-coat
Or the protectiveness coating material of polymeric material clothing and wax polishing clothing composition.Dyestuff can be added in these coating materials to distinguish
Different unit doses.
Oral liquid such as solution, syrup and elixir can be prepared with dosage unit form, so that specified rate contains
There is the compound of predetermined amount.Syrup can be prepared by the way that compound to be dissolved in suitably seasoned aqueous solution, and elixir can lead to
It crosses using non-toxic vehicle and prepares.Can also be added preservative, flavoring additive (such as peppermint oil or natural sweetener or saccharin or
Other artificial sweeteners) etc..
Pharmaceutical preparation suitable for percutaneous dosing can be used as discrete patch to keep close with recipient's epidermis in a long time
Cut-grafting touching.For example, active constituent can be by passing medicine by electro-ionic osmosis patch, usually reference can be made to Pharmaceutical
Research1986,3(6),318。
Pharmaceutical preparation suitable for local administration can be made into ointment, cream, suspension, lotion, powder, solution, paste
Agent, gelling agent, spray, aerosol, oil formulation or transdermal patch.
Pharmaceutical preparation (wherein carrier is solid) suitable for nose administration includes that partial size is such as 20-500 micron range
Dust base is quickly sucked from the coarse powder agent container close to nose by being administered in a manner of snuffing by nasal passage.Wherein carry
Body is liquid, is suitable for aqueous solution agent or oil that the appropriate formulation that nasal mist or nasal drop are administered includes active constituent
Property solution.
Include minuteness particle pulvis or mist agent suitable for the pharmaceutical preparation by inhalation, can be measured with different type
Dosage compresed gas aerosol, nebulizer, insufflator or other matters delivering aerosol spray device in prepare.
Pharmaceutical preparation suitable for parenteral includes water-based and non-aqueous sterile injection solution and aqueous and non-aqueous
Sterile suspensions, water-based and non-aqueous sterile injection solution can contain antioxidant, buffer, bacteriostatic agent and make the preparation
The isotonic solute with receptor's blood waiting.Preparation can be provided with unit dose or multi-dose container, such as the peace of sealing is triumphant and small
Bottle, and can be reserved under the conditions of freeze-drying (freeze-drying), only sterile liquid carrier, such as water for injection need to be added before use.
The injection solution for facing used time configuration can be prepared by sterile powder injection, granule and tablet.
Pharmaceutical preparation can be in unit dosage forms, and each unit dose contains the active constituent of predetermined amount.Dose regimen can be used as growing
Phase or short-term therapy.Mixing with carrier material will be according to disease to be treated, disease to prepare the amount of the active constituent of single formulation
Disease severity, administration time, administration route, the discharge rate of compound used therefor, treatment time and patient age, gender,
Weight and situation and change.Preferred unit dosage forms are the daily dose containing above-mentioned active constituent or divided dose or its appropriate fraction
Unit dosage forms.It can start to treat with the low dose of already clearly below compound optimal dose.Hereafter, it is increased with lesser increment
Dosage until reaching optimum efficiency in this case.In general, the concentration level for most desirably giving compound is usual
Effective result can be provided without regard to causing any harmful or toxic side effect in anti-virus aspect.
When composition of the invention can also be with the combination of one or more other treatment drugs or prophylactic agent, compound
Dosage level with other drug accounts for the about 10-150% of normal dosage, more preferably usually in monotherapy scheme
Account for the about 10-80% of normal dosage.
Preferably, Chinese medicine composition of the invention can with include but is not limited to following treatment shingles zoster activity at
Divide and be used in combination: antiviral treatment: acyclovir, Valaciclovir, famciclovir or Ganciclovir；Neuralgia drug is controlled
Treat: 1. antidepressants key agents have Paxil (Sai Lete), Prozac (prozac), Clovoxamine, Sertraline etc.；②
Anticonvulsive drug has carbamazepine, sodium vedproate etc..3. narcotic analgeiscs is using morphine as the analgesic of representative.Available medicine
Object has morphine (Morphine), hydroxymorphinone (OxyContin), Oxycodone, fentanyl (Durogesic), dihydroetorphine, Lu Gai
Gram etc..4. non-narcotic analgesics include NSAIDs, bent more, aconite alkaloid, capsaicine etc..
Herpesvirus infection mentioned by the present invention includes herpes simplex virus I-type, II type and varicellazoster virus institute
The herpes simplex viral infections and herpes zoster virus infection of cause.
Herpesvirus infection associated diseases mentioned by the present invention also wrap in addition to including herpes simplex, shingles zoster
Include the skin lesion pain generated during herpes episodes and forerunner's neuralgia and postherpes neuralgia PHN.
The beneficial effects of the present invention are: Chinese medicine composition of the invention uses traditional Chinese medicine for raw material, and toxic side effect is small,
It is obvious to treat shingles zoster effect, and postherpes neuralgia PHN can be prevented and treated.Either systemic administration or part
Medication, effect are better than bleb common medicine acyclovir.Chinese medicine composition of the invention can shorten bleb cure time, allow trouble
Person walks out disease shade as early as possible, beneficial to the physical and mental health of patient.
Specific embodiment
It detailed description of a preferred embodiment of the present invention will be given below.The reality of actual conditions is not specified in preferred embodiment
Proved recipe method, usually according to normal condition, illustrated embodiment are but not to be to preferably be illustrated to the contents of the present invention
The contents of the present invention are only limitted to illustrated embodiment.So those skilled in the art are according to foregoing invention content to embodiment party
Case carries out nonessential modifications and adaptations, still falls within protection scope of the present invention.
Embodiment 1
Rhizoma atractylodis 80g, dried orange peel 80g, Cortex Magnoliae Officinalis (ginger system) 80g, root of Dahurain angelica 120g, Poria cocos 120g, shell of areca nut 120g, dried pinellia
80g, extract of licorice root 10g, patchouli oil 0.8ml, perilla leaf oil 0.4ml.Rhizoma atractylodis, dried orange peel, the root of Dahurain angelica, Cortex Magnoliae Officinalis add 60% ethyl alcohol to mention
It takes, filters, filtrate is spare；Poria cocos, the shell of areca nut add water to cook, decocting liquid filtration, and filtrate is spare；Dried pinellia is soaked in water, and is steeped to saturating
After the heart, separately add 13.5 parts by weight of rhizoma zingiberis, add water to cook, decocting liquid filters, and filtrate is spare；Extract of licorice root is smashed rear boiling and is melted；It closes
And said extracted liquid, filtration, filtrate are distilled to recover ethyl alcohol；Patchouli oil, perilla leaf oil is added, mixes, adds water to 1025ml, adjusts
PH to 5.8-6.2 is saved, stands, filters to obtain clear solution, is sterilized, it is filling to obtain solution.
Embodiment 2
Rhizoma atractylodis 80g, dried orange peel 80g, Cortex Magnoliae Officinalis (ginger system) 80g, root of Dahurain angelica 120g, Poria cocos 120g, shell of areca nut 120g, dried pinellia
80g, extract of licorice root 10g, patchouli oil 0.8ml, perilla leaf oil 0.4ml.Rhizoma atractylodis, dried orange peel, the root of Dahurain angelica, Cortex Magnoliae Officinalis add 60% ethyl alcohol to mention
It takes, filters, filtrate is spare；Poria cocos, the shell of areca nut add water to cook, decocting liquid filtration, and filtrate is spare；Dried pinellia is soaked in water, and is steeped to saturating
After the heart, separately add 13.5 parts by weight of rhizoma zingiberis, add water to cook, decocting liquid filters, and filtrate is spare；Extract of licorice root is smashed rear boiling and is melted；It closes
And said extracted liquid, filtration, filtrate are concentrated into the thick paste of relative density 1.30-1.35；Appropriate Macrogol 6000 0 is taken, is heated
Make to melt, patchouli oil, perilla leaf oil and above-mentioned thick paste is added, mix, dripping pelletization, film coating obtains pill.
Embodiment 3
Rhizoma atractylodis 80g, dried orange peel 80g, Cortex Magnoliae Officinalis (ginger system) 80g, root of Dahurain angelica 120g, Poria cocos 120g, shell of areca nut 120g, dried pinellia
80g, extract of licorice root 10g, patchouli oil 0.8ml, perilla leaf oil 0.4ml.Rhizoma atractylodis, dried orange peel, the root of Dahurain angelica, Cortex Magnoliae Officinalis add 60% ethyl alcohol to mention
It takes, filters, filtrate is spare；Poria cocos, the shell of areca nut add water to cook, decocting liquid filtration, and filtrate is spare；Dried pinellia is soaked in water, and is steeped to saturating
After the heart, separately add 13.5 parts by weight of rhizoma zingiberis, add water to cook, decocting liquid filters, and filtrate is spare；Extract of licorice root is smashed rear boiling and is melted；It closes
And said extracted liquid, filtration, filtrate are concentrated into right amount.Patchouli oil, perilla leaf oil are dissolved with appropriate amount of ethanol.Merge above molten
Liquid, mixing adjust ethanol content with ethyl alcohol and appropriate amount of water, and make full dose at 1025ml, stand, and filtration is filling to obtain tincture.
Embodiment 4
Rhizoma atractylodis 80g, dried orange peel 80g, Cortex Magnoliae Officinalis (ginger system) 80g, root of Dahurain angelica 120g, Poria cocos 120g, shell of areca nut 120g, dried pinellia
80g, extract of licorice root 10g, patchouli oil 0.8ml, perilla leaf oil 0.4ml.Rhizoma atractylodis, dried orange peel, the root of Dahurain angelica, Cortex Magnoliae Officinalis add 60% ethyl alcohol to mention
It takes, filters, filtrate is spare；Poria cocos, the shell of areca nut add water to cook, decocting liquid filtration, and filtrate is spare；Dried pinellia is soaked in water, and is steeped to saturating
After the heart, separately add 13.5 parts by weight of rhizoma zingiberis, add water to cook, decocting liquid filters, and filtrate is spare；Extract of licorice root is smashed rear boiling and is melted；It closes
And said extracted liquid, filtration, filtrate are concentrated into the thick paste of relative density 1.15-1.25；Patchouli oil, perilla leaf oil are gathered with appropriate
Ethylene glycol 400 is added in thick paste after dissolving and mixes.Taking polyethylene glycol 4000 is appropriate, is heated to melting in 55 DEG C of water-baths, then plus
Enter above-mentioned thick paste to stir evenly, be cooled to room temperature.
Clinical case
Case selection: all cases are all from May, 2016 to dermatology of Fuling District institute of traditional Chinese medicine of Chongqing City's in March, 2017 door
Diagnose a disease people, is diagnosed as shingles zoster, (Zhao distinguishes chief editor Jiangsu science tech publishing house to diagnostic criteria referring to " clinical dermatology "
The 3rd edition page 302 of April in 2001), it is followed by cluster papule, papulo-vesicle, blister that initial fash, which is erythema, is in tufted；Fash
Along side Substance P, arrangement becomes band, with apparent neuralgia.
Exclusion criteria: known to trial drug Related Component and acyclovir allergy sufferers；There is serious immunologic hypofunction,
Or cortin and immunosuppressor person need to be taken for a long time；There are the serious heart, Liver and kidney function impairer；With psychoneural disease
Disease or the serious blood circulatory system and endocrine system disease person；Antiviral drugs and immunomodulator were applied in 1 week；Gestation and the food in one's mouth
Newborn phase women；There are excessive drinking history or drug abuse history person in the recent period；Other drugs experimenter was participated in 3 months.
Patient's grouping: finally having 84 patients to complete experiment, wherein male 43, and women 41, average age 47.6 years old,
Patient is equally divided into three groups, and every group of 28 people are successively numbered according to consultation time and sign informed consent form.Three groups it
Between male to female ratio, age distribution, course of disease time without significant difference, is comparable.
Treatment method
Trial drug group 1: embodiment 10mL of 1 solution, twice a day；
Trial drug group 2: 4 ointment of embodiment applies affected part；Six times a day.
Control group 3: acyclovir 2.0g intravenous drip, once a day；Acyclovir ointment applies affected part, six times a day.
Data statistics: it is analyzed using 18.0 statistical analysis software of SPSS.Measurement data with mean ± standard deviation (x ±
SD it) indicates, data compare between group is examined using t, and P < 0.05 indicates that difference is statistically significant.
Symptom and sign evaluation index and result
(1) scores of erythema: 0 point: nothing；1 point: light red；2 points: red, no oedema；3 points: scarlet, Mild edema；4 points: it is dark red,
Obvious oedema.
* P < 0.05 is indicated
(2) blister size scores: 0 point: without blister；1 point: blister is dry or forms a scab；2 points: blister diameter≤0.2cm；3
Point: 0.2cm < blister diameter≤0.4cm；4 points: blister diameter > 0.5cm.
(3) blister form scores: 0 point: without blister or incrustation；1 point: papulo-vesicle；2 points: limpid vesicle fluid is without ulceration；3 points: blister
Liquid is muddy or slight erosion；4 points: blood blister, warts or fester.
Blister size and form score are total, and statistics scoring is as follows in treatment cycle:
* P < 0.05 is indicated
(4) skin lesion pain degree scores: right using visual analogue scales (Visual Analogue Scale, VAS)
The pretherapy and post-treatment conscious pain intensity of patient is evaluated, and indicates patient pain's intensity and pain to psychological, smart to correspond to score value
Impact on mind, 0 point is painless；1~3 point: mild pain can still be engaged in normal activity；4~6 points of moderate pains, influence work
Make, but life remains to take care of oneself；7~10 points, severe pain seriously affects Working Life.
| Group | Before treatment | 1d | 5d | 7d | 10d |
| Medicine group 1 | 2.53±0.27 | 2.12±0.14 | 1.68±0.15* | 1.22±0.14* | 0.82±0.24* |
| Medicine group 2 | 2.51±0.36 | 2.15±0.32 | 1.64±0.27* | 1.20±0.18* | 0.61±0.26* |
| Control group | 2.55±0.24 | 2.36±0.26 | 2.03±0.13 | 1.85±0.26 | 1.81±0.41 |
* P < 0.05 is indicated
(5) a situation arises for post herpetic neuralgia: 30 days follow-up nerve pain situations after bleb clinical healing, counts as follows:
| Group | N | Number of cases occurs for post herpetic neuralgia | Incidence |
| Medicine group 1 | 28 | 0 | 0 |
| Medicine group 2 | 28 | 0 | 0 |
| Control group | 28 | 4 | 14.3% |
Clinical treatment outcome shows that using the band-like bleb definite effect of drug therapy of the present invention, and therapeutic effect is obviously excellent
In control drug acyclovir.By clinical treatment, it has surprisingly been found that, drug of the invention is in treatment other clinical symptoms of bleb
While, additionally it is possible to the generation of effective prevention postherpes neuralgia PHN.
Finally, it is stated that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to compared with
Good embodiment describes the invention in detail, those skilled in the art should understand that, it can be to skill of the invention
Art scheme is modified or replaced equivalently, and without departing from the objective and range of technical solution of the present invention, should all be covered at this
In the scope of the claims of invention.
Claims (9)
1. a kind of application of Chinese medicine composition in the drug of preparation treatment herpesvirus infection associated diseases, which is characterized in that
The Traditional Chinese medicine composition formula is as follows: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnoliae Officinalis, 120 parts by weight of the root of Dahurain angelica,
120 parts by weight of Poria cocos, 120 parts by weight of the shell of areca nut, 80 parts by weight of dried pinellia, 10 parts by weight of extract of licorice root, 0.8 volume of patchouli oil
Part and 0.4 parts by volume of perilla leaf oil.
2. application of the Chinese medicine composition as described in claim 1 in the drug of preparation treatment herpesvirus infection associated diseases,
It is characterized in that, the preparation method of the Chinese medicine composition includes the following steps: to prepare above-mentioned Chinese medicine by formula ratio, rhizoma atractylodis,
Dried orange peel, the root of Dahurain angelica, Cortex Magnoliae Officinalis add ethyl alcohol to extract, filtration, and filtrate is spare；Poria cocos, the shell of areca nut add water to cook, decocting liquid filtration, and filtrate is spare；
Dried pinellia is soaked in water, and after bubble to the saturating heart, is added water to cook, decocting liquid filtration, and filtrate is spare；Extract of licorice root is smashed rear boiling and is melted,
Filtration, filtrate are spare；Merge above-mentioned filtrate；Patchouli oil is added, perilla leaf oil mixes.
3. Chinese medicine composition as claimed in claim 1 or 2 answering in the drug of preparation treatment herpesvirus infection associated diseases
With, which is characterized in that the drug of the treatment bleb can be any pharmaceutically acceptable dosage form.
4. Chinese medicine composition as claimed in claim 1 or 2 answering in the drug of preparation treatment herpesvirus infection associated diseases
With, which is characterized in that the drug of the preparation treatment bleb further includes pharmaceutical acceptable carrier and/or auxiliary agent.
5. Chinese medicine composition as claimed in claim 1 or 2 answering in the drug of preparation treatment herpesvirus infection associated diseases
With, which is characterized in that the drug of the preparation treatment bleb further includes other active components.
6. Chinese medicine composition as claimed in claim 1 or 2 answering in the drug of preparation treatment herpesvirus infection associated diseases
With, which is characterized in that the herpesviral includes herpes simplex virus I, II type or varicellazoster virus.
7. Chinese medicine composition as claimed in claim 1 or 2 answering in the drug of preparation treatment herpesvirus infection associated diseases
With, which is characterized in that the disease is herpes simplex or shingles zoster caused by herpesvirus infection.
8. Chinese medicine composition as claimed in claim 1 or 2 answering in the drug of preparation treatment herpesvirus infection associated diseases
With, which is characterized in that the disease is that herpesvirus infection is pain caused.
9. Chinese medicine composition as claimed in claim 1 or 2 answering in the drug of preparation treatment herpesvirus infection associated diseases
With, which is characterized in that the disease is skin lesion pain, forerunner's neuralgia or post herpetic neuralgia caused by herpesvirus infection.
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| CN109453280A (en) * | 2019-01-07 | 2019-03-12 | 重庆太极实业（集团）股份有限公司 | A kind of Chinese medicine composition is for treating the application in mucosa injury associated diseases |
| CN109498728A (en) * | 2019-01-07 | 2019-03-22 | 重庆太极实业（集团）股份有限公司 | A kind of antimycotic Chinese medicine composition and its preparation method and application |
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| CN103272092A (en) * | 2012-12-07 | 2013-09-04 | 海南德泽药物研究有限公司 | Huoxiang Zhengqi externally-applied preparation and its preparation method and application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109453280A (en) * | 2019-01-07 | 2019-03-12 | 重庆太极实业（集团）股份有限公司 | A kind of Chinese medicine composition is for treating the application in mucosa injury associated diseases |
| CN109498728A (en) * | 2019-01-07 | 2019-03-22 | 重庆太极实业（集团）股份有限公司 | A kind of antimycotic Chinese medicine composition and its preparation method and application |
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Application publication date: 20181207 |