CN105434536A - Medicine composition treating altitude stress and preparation method and application thereof - Google Patents
Medicine composition treating altitude stress and preparation method and application thereof Download PDFInfo
- Publication number
- CN105434536A CN105434536A CN201510902379.XA CN201510902379A CN105434536A CN 105434536 A CN105434536 A CN 105434536A CN 201510902379 A CN201510902379 A CN 201510902379A CN 105434536 A CN105434536 A CN 105434536A
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical composition
- radix
- altitude sickness
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Abstract
The invention discloses a medicine composition treating altitude stress and a preparation method and application thereof. The medicine composition is prepared from liquorice roots, Chinese caterpillar fungus, rhodiola rosea, felwort, indigo naturalis, pagaeophyton scapiflorum, caulis spatholobi, rhodomyrtus tomentosa, viburnum lutescens Bl., diazepam and meprobamate by weight. In the preparation process, after the raw materials are weighed, the liquorice roots, the Chinese caterpillar fungus, the rhodiola rosea and the felwort are ground into powder, the indigo naturalis, the pagaeophyton scapiflorum and the caulis spatholobi are subjected to warm immersion in ethyl alcohol and then subjected to heating reflux extraction, the rhodomyrtus tomentosa and the viburnum lutescens Bl. are added with water to be decocted and extracted, an obtained product and the other raw materials are mixed and added into a carrier, and the finished product is obtained. The medicine composition can increase the oxygen intake of the human body, has the functions of protecting the heart, the nervous system and the digestive system, can effectively relieve headache, appetite loss, lassitude, weakness, dizziness and other symptoms caused by altitude stress, is free of toxic and side effects and provides a new choice for clinically preventing and treating various symptoms caused by altitude stress.
Description
Technical field
The present invention relates to medical applications technical field, specifically a kind ofly treat pharmaceutical composition of altitude sickness medicine and its production and use.
Background technology
Acute high altitude reaction is the clinical syndrome occurred because high altitude anoxia causes somatic damage, is a kind of modal acute high altitude sickness.Clinical symptoms shows as headache, dizziness, nervous, uncomfortable in chest, Nausea and vomiting, weak, poor appetite, sleep disorder, brothers are numb, can edema etc. be there is in face and extremity, as can not get properly treating process, plateau pneumochysis and high altitude cerebral adema etc. can be developed into, entail dangers to is to the life security of sufferer, and prevention and the treatment of acute high altitude sickness are one of the difficult point in current medical field.Special effectively preventing medicine is there is no at present on the market for acute high altitude reaction.Application Rhodiola rosea capsules control acute high altitude reaction, the process of taking reaches one week, and effect is slow and unstable, clinical response unsatisfactory curative effect, especially unsatisfactory to clinical headache, dizziness, the symptom effect such as uncomfortable in chest.Current, China goes to that travel in highlands, the people of Working Life reaches 20,000,000 more than every year, and with annual 15% speed increment, develop medicine, the health product with resisting oxygen lack and there is wide market prospect and good social benefit.
Chinese medicine is owing to having unique theoretical basis, advantage that toxic and side effects is little, huge advantage is shown in altitude sickness treatment, it can overcome the shortcoming that Western medicine index is not effected a permanent cure, while playing powerful resisting oxygen lack, and conditioner body immunity function on the whole.
Summary of the invention
The object of the present invention is to provide and a kind ofly treat pharmaceutical composition of altitude sickness medicine and its production and use.
For achieving the above object, the invention provides following technical scheme:
Treat a pharmaceutical composition for altitude sickness medicine, be made up of the following raw material according to weight portion: Radix Glycyrrhizae 15-20 part, Cordyceps 5-10 part, Radix Rhodiolae 5-10 part, Radix Gentianae 3-8 part, Indigo Naturalis 2-4 part, acaulescent pegaeophyton herb 2-4 part, Caulis Spatholobi 2-4 part, Fructus Rhodomyrti 1-3 part, Luo Gaiye 1-3 part, Amiprol 0.2-0.6 part, meprobamate 0.2-0.6 part.
As the further scheme of the present invention: the pharmaceutical composition of described treatment altitude sickness medicine, is made up of the following raw material according to weight portion: Radix Glycyrrhizae 16-18 part, Cordyceps 6-9 part, Radix Rhodiolae 6-9 part, Radix Gentianae 4-6 part, Indigo Naturalis 2.5-3.5 part, acaulescent pegaeophyton herb 2.5-3.5 part, Caulis Spatholobi 2.5-3.5 part, Fructus Rhodomyrti 1.5-2.5 part, Luo Gaiye 1.5-2.5 part, Amiprol 0.3-0.5 part, meprobamate 0.3-0.5 part.
As the further scheme of the present invention: the pharmaceutical composition of described treatment altitude sickness medicine, is made up of the following raw material according to weight portion: 17 parts, Radix Glycyrrhizae, Cordyceps 8 parts, Radix Rhodiolae 8 parts, Radix Gentianae 5 parts, Indigo Naturalis 3 parts, acaulescent pegaeophyton herb 3 parts, Caulis Spatholobi 3 parts, Fructus Rhodomyrti 2 parts, Luo Gaiye 2 parts, Amiprol 0.4 part, meprobamate 0.4 part.
The preparation method of the pharmaceutical composition of described treatment altitude sickness medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Radix Glycyrrhizae, Cordyceps, Radix Rhodiolae and Radix Gentianae are carried out grinding 5-6h and obtain mixed-powder;
(3) Indigo Naturalis, acaulescent pegaeophyton herb and Caulis Spatholobi are added the ethanol warm macerating 25-30min post-heating reflux, extract, twice of 60-65%, first time extracts 2.5-3h, and second time extracts 2-2.5h, has extracted rear merging extracted twice liquid, decompression recycling ethanol, after filtering, filtrate is for subsequent use;
(4) Fructus Rhodomyrti and Luo Gaiye are decocted with water twice, first time decocts 2-2.5h, and second time decocts 1.5-2h, merge decoction liquor, the filtrate that step (3) obtains mixed homogeneously with decoction liquor after filtration, being concentrated into relative density is 1.23-1.27, obtains extractum;
(5) mixed-powder added in Amiprol, meprobamate and step (2) mixes to extractum;
(6) add carrier, make described pharmaceutical composition finished product.
As the further scheme of the present invention: described carrier is one or more in xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, Cera Flava, allantoin, calcium stearate, magnesium stearate.
As the further scheme of the present invention: described pharmaceutical composition is tablet, capsule, oral liquid, suck agent, granule, pill, pellet, powder, mixture, drop pill, unguentum, injection, cream, spray, drop or patch.
As the present invention's further scheme: the application of described pharmaceutical composition in preparation treatment altitude sickness medicine.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention can improve human body QO2; there is the function of cardioprotection, nerve and digestive system; preparation technology is simple, environmentally friendly; effectively can alleviate headache that altitude sickness causes, loss of appetite, asthenia, the symptom such as weak and dizzy; there is no toxic and side effects; for clinical prevention treatment altitude sickness disease, the various symptoms that alleviation altitude sickness causes provide one and newly select.
Detailed description of the invention
Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.
Embodiment 1
Treat a pharmaceutical composition for altitude sickness medicine, be made up of the following raw material according to weight portion: 15 parts, Radix Glycyrrhizae, Cordyceps 5 parts, Radix Rhodiolae 5 parts, Radix Gentianae 3 parts, Indigo Naturalis 2 parts, acaulescent pegaeophyton herb 2 parts, Caulis Spatholobi 2 parts, Fructus Rhodomyrti 1 part, Luo Gaiye 1 part, Amiprol 0.2 part, meprobamate 0.2 part.
The preparation method of the pharmaceutical composition of described treatment altitude sickness medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Radix Glycyrrhizae, Cordyceps, Radix Rhodiolae and Radix Gentianae are carried out grinding 5h and obtain mixed-powder;
(3) Indigo Naturalis, acaulescent pegaeophyton herb and Caulis Spatholobi are added the ethanol warm macerating 25min post-heating reflux, extract, twice of 60%, first time extracts 2.5h, and second time extracts 2h, has extracted rear merging extracted twice liquid, decompression recycling ethanol, and after filtering, filtrate is for subsequent use;
(4) Fructus Rhodomyrti and Luo Gaiye are decocted with water twice, first time decocts 2h, and second time decocts 1.5h, and merge decoction liquor, the filtrate that step (3) obtains mixed homogeneously with decoction liquor after filtration, being concentrated into relative density is 1.23, obtains extractum;
(5) mixed-powder added in Amiprol, meprobamate and step (2) mixes to extractum;
(6) add xylitol, maltose and glucose, make the tablet finished product of described pharmaceutical composition.
Usage and dosage: oral.A 2-5g, 3 times on the one.
Embodiment 2
Treat a pharmaceutical composition for altitude sickness medicine, be made up of the following raw material according to weight portion: 16 parts, Radix Glycyrrhizae, Cordyceps 6 parts, Radix Rhodiolae 6 parts, Radix Gentianae 4 parts, Indigo Naturalis 2.5 parts, acaulescent pegaeophyton herb 2.5 parts, Caulis Spatholobi 2.5 parts, Fructus Rhodomyrti 1.5 parts, Luo Gaiye 1.5 parts, Amiprol 0.3 part, meprobamate 0.3 part.
The preparation method of the pharmaceutical composition of described treatment altitude sickness medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Radix Glycyrrhizae, Cordyceps, Radix Rhodiolae and Radix Gentianae are carried out grinding 5.2h and obtain mixed-powder;
(3) Indigo Naturalis, acaulescent pegaeophyton herb and Caulis Spatholobi are added the ethanol warm macerating 26min post-heating reflux, extract, twice of 61%, first time extracts 2.6h, and second time extracts 2.1h, has extracted rear merging extracted twice liquid, decompression recycling ethanol, and after filtering, filtrate is for subsequent use;
(4) Fructus Rhodomyrti and Luo Gaiye are decocted with water twice, first time decocts 2.1h, and second time decocts 1.6h, merge decoction liquor, the filtrate that step (3) obtains mixed homogeneously with decoction liquor after filtration, being concentrated into relative density is 1.24, obtains extractum;
(5) mixed-powder added in Amiprol, meprobamate and step (2) mixes to extractum;
(6) add fructose, dextran and glycine, make described medicament composition capsule agent finished product.
Usage and dosage: oral.A 1-4g, 3 times on the one.
Embodiment 3
Treat a pharmaceutical composition for altitude sickness medicine, be made up of the following raw material according to weight portion: 17 parts, Radix Glycyrrhizae, Cordyceps 8 parts, Radix Rhodiolae 8 parts, Radix Gentianae 5 parts, Indigo Naturalis 3 parts, acaulescent pegaeophyton herb 3 parts, Caulis Spatholobi 3 parts, Fructus Rhodomyrti 2 parts, Luo Gaiye 2 parts, Amiprol 0.4 part, meprobamate 0.4 part.
The preparation method of the pharmaceutical composition of described treatment altitude sickness medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Radix Glycyrrhizae, Cordyceps, Radix Rhodiolae and Radix Gentianae are carried out grinding 5.5h and obtain mixed-powder;
(3) Indigo Naturalis, acaulescent pegaeophyton herb and Caulis Spatholobi are added the ethanol warm macerating 27min post-heating reflux, extract, twice of 62%, first time extracts 2.7h, and second time extracts 2.2h, has extracted rear merging extracted twice liquid, decompression recycling ethanol, and after filtering, filtrate is for subsequent use;
(4) Fructus Rhodomyrti and Luo Gaiye are decocted with water twice, first time decocts 2.2h, and second time decocts 1.7h, merge decoction liquor, the filtrate that step (3) obtains mixed homogeneously with decoction liquor after filtration, being concentrated into relative density is 1.25, obtains extractum;
(5) mixed-powder added in Amiprol, meprobamate and step (2) mixes to extractum;
(6) add starch, sucrose, lactose and mannitol, make described drug composition oral liquid finished product.
Usage and dosage: oral.A 5-8g, 3 times on the one.
Embodiment 4
Treat a pharmaceutical composition for altitude sickness medicine, be made up of the following raw material according to weight portion: 18 parts, Radix Glycyrrhizae, Cordyceps 9 parts, Radix Rhodiolae 9 parts, Radix Gentianae 6 parts, Indigo Naturalis 3.5 parts, acaulescent pegaeophyton herb 3.5 parts, Caulis Spatholobi 3.5 parts, Fructus Rhodomyrti 2.5 parts, Luo Gaiye 2.5 parts, Amiprol 0.5 part, meprobamate 0.5 part.
The preparation method of the pharmaceutical composition of described treatment altitude sickness medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Radix Glycyrrhizae, Cordyceps, Radix Rhodiolae and Radix Gentianae are carried out grinding 5.8h and obtain mixed-powder;
(3) Indigo Naturalis, acaulescent pegaeophyton herb and Caulis Spatholobi are added the ethanol warm macerating 28min post-heating reflux, extract, twice of 64%, first time extracts 2.8h, and second time extracts 2.4h, has extracted rear merging extracted twice liquid, decompression recycling ethanol, and after filtering, filtrate is for subsequent use;
(4) Fructus Rhodomyrti and Luo Gaiye are decocted with water twice, first time decocts 2.4h, and second time decocts 1.8h, merge decoction liquor, the filtrate that step (3) obtains mixed homogeneously with decoction liquor after filtration, being concentrated into relative density is 1.26, obtains extractum;
(5) mixed-powder added in Amiprol, meprobamate and step (2) mixes to extractum;
(6) add glycerol and Cera Flava, make described pharmaceutical composition and suck agent finished product.
Usage and dosage: oral.A 1-3g, 3 times on the one.
Embodiment 5
Treat a pharmaceutical composition for altitude sickness medicine, be made up of the following raw material according to weight portion: 20 parts, Radix Glycyrrhizae, Cordyceps 10 parts, Radix Rhodiolae 10 parts, Radix Gentianae 8 parts, Indigo Naturalis 4 parts, acaulescent pegaeophyton herb 4 parts, Caulis Spatholobi 4 parts, Fructus Rhodomyrti 3 parts, Luo Gaiye 3 parts, Amiprol 0.6 part, meprobamate 0.6 part.
The preparation method of the pharmaceutical composition of described treatment altitude sickness medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Radix Glycyrrhizae, Cordyceps, Radix Rhodiolae and Radix Gentianae are carried out grinding 6h and obtain mixed-powder;
(3) Indigo Naturalis, acaulescent pegaeophyton herb and Caulis Spatholobi are added the ethanol warm macerating 30min post-heating reflux, extract, twice of 65%, first time extracts 3h, and second time extracts 2.5h, has extracted rear merging extracted twice liquid, decompression recycling ethanol, and after filtering, filtrate is for subsequent use;
(4) Fructus Rhodomyrti and Luo Gaiye are decocted with water twice, first time decocts 2.5h, and second time decocts 2h, and merge decoction liquor, the filtrate that step (3) obtains mixed homogeneously with decoction liquor after filtration, being concentrated into relative density is 1.27, obtains extractum;
(5) mixed-powder added in Amiprol, meprobamate and step (2) mixes to extractum;
(6) add cyclodextrin, make described medicament composition granule agent finished product.
Usage and dosage: oral.A 2-5g, 3 times on the one.
Comparative example 1
Treat a pharmaceutical composition for altitude sickness medicine, be made up of the following raw material according to weight portion: 17 parts, Radix Glycyrrhizae, Cordyceps 8 parts, Radix Rhodiolae 8 parts, Radix Gentianae 5 parts, Indigo Naturalis 3 parts, acaulescent pegaeophyton herb 3 parts, Caulis Spatholobi 3 parts, Fructus Rhodomyrti 2 parts, Luo Gaiye 2 parts, Amiprol 0.4 part.
The preparation method of the pharmaceutical composition of described treatment altitude sickness medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Radix Glycyrrhizae, Cordyceps, Radix Rhodiolae and Radix Gentianae are carried out grinding 5.5h and obtain mixed-powder;
(3) Indigo Naturalis, acaulescent pegaeophyton herb and Caulis Spatholobi are added the ethanol warm macerating 27min post-heating reflux, extract, twice of 62%, first time extracts 2.7h, and second time extracts 2.2h, has extracted rear merging extracted twice liquid, decompression recycling ethanol, and after filtering, filtrate is for subsequent use;
(4) Fructus Rhodomyrti and Luo Gaiye are decocted with water twice, first time decocts 2.2h, and second time decocts 1.7h, merge decoction liquor, the filtrate that step (3) obtains mixed homogeneously with decoction liquor after filtration, being concentrated into relative density is 1.25, obtains extractum;
(5) mixed-powder added in Amiprol and step (2) mixes to extractum;
(6) add starch, sucrose, lactose and mannitol, make described drug composition oral liquid finished product.
Usage and dosage: oral.A 5-8g, 3 times on the one.
Comparative example 2
Treat a pharmaceutical composition for altitude sickness medicine, be made up of the following raw material according to weight portion: 18 parts, Radix Glycyrrhizae, Cordyceps 9 parts, Radix Rhodiolae 9 parts, Radix Gentianae 6 parts, Indigo Naturalis 3.5 parts, acaulescent pegaeophyton herb 3.5 parts, Caulis Spatholobi 3.5 parts, Fructus Rhodomyrti 2.5 parts, Amiprol 0.5 part, meprobamate 0.5 part.
The preparation method of the pharmaceutical composition of described treatment altitude sickness medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Radix Glycyrrhizae, Cordyceps, Radix Rhodiolae and Radix Gentianae are carried out grinding 5.8h and obtain mixed-powder;
(3) Indigo Naturalis, acaulescent pegaeophyton herb and Caulis Spatholobi are added the ethanol warm macerating 28min post-heating reflux, extract, twice of 64%, first time extracts 2.8h, and second time extracts 2.4h, has extracted rear merging extracted twice liquid, decompression recycling ethanol, and after filtering, filtrate is for subsequent use;
(4) Fructus Rhodomyrti is decocted with water twice, first time decocts 2.4h, and second time decocts 1.8h, and merge decoction liquor, the filtrate that step (3) obtains mixed homogeneously with decoction liquor after filtration, being concentrated into relative density is 1.26, obtains extractum;
(5) mixed-powder added in Amiprol, meprobamate and step (2) mixes to extractum;
(6) add glycerol and Cera Flava, make described pharmaceutical composition and suck agent finished product.
Usage and dosage: oral.A 1-3g, 3 times on the one.
Embodiment 6
Clinical trial
(1) subjects: adopt the present invention to treat 750 routine patients altogether, wherein man 450 example, female 300 example; The oldest person 72 years old, age reckling 15.
(2) diagnostic criteria: headache, giddy, nausea and vomiting, palpitation and short breath, feeling of oppression and pain in the chest, insomnia, drowsiness, loss of appetite, abdominal distention, brothers are numb, pulse significantly speeds, blood pressure slight or moderate raises, lip or finger is issued, eyelid or puffiness of face.
(3) Therapeutic Method: man 450 example, the routine patient of female 300 are equally divided into six groups, often group man 75 example, female 50 example, one group, two groups, three groups and four groups are test group, one group, two groups, three groups and Four composition do not take the pharmaceutical composition of the treatment altitude sickness medicine of the present invention that embodiment 1-embodiment 4 prepares, five groups and six groups is matched group, five groups and the six groups pharmaceutical compositions taken comparative example 1 and comparative example 2 respectively and prepare, method of administration is one after each meal every day, one day 3 times, a dose is 2-5g, 2 days courses for the treatment of.
(4) standard is treated
Cure: symptom all disappears, physical rehabilitation, follows up a case by regular visits to first quarter moon without recurrence;
Take a turn for the better: disease obviously alleviates, and treatments period symptom disappears substantially, energy orthobiosis and work;
Invalid: before and after medication, symptom is without change.
(5) therapeutic outcome: how to take effect after 2 days after taking medicine in the routine case of patient 200,2-3 the course for the treatment of cures; Wherein control
More 128 examples, effective 15 examples, effective 5 examples, invalid 2 examples, total effective rate reaches 98.7%, and therapeutic outcome is as shown in table 1:
Table 1: clinical trial therapeutic outcome
As shown in Table 1, the average effectiveness level adopting treatment altitude sickness pharmaceutical composition of the present invention to carry out treating reaches 98.6%, the effective percentage of the pharmaceutical composition adopting comparative example to prepare only has 76.41%, therefore, between pharmaceutical composition of the present invention, there is synergistic function, add the effective percentage of pharmaceutical composition.
Model case:
(1) Zhang, man, 38 years old, enters headache behind plateau, dizzy, nausea and vomiting, cannot take food, and after taking 2 courses for the treatment of of pharmaceutical composition of the present invention, above-mentioned symptom is clearly better, and disease is eliminated.
(2) wool grass, female, 51 years old, abdominal distention after entering plateau, brothers were numb, pulse significantly speeds, and take pharmaceutical composition of the present invention 1 day, above-mentioned symptom is clearly better, and abdominal distention alleviates, and improves the complexion, and after continuing to take 2 courses for the treatment of, disease disappears, and serious disease is fully recovered.
(3) Hu, man, 20 years old, after entering plateau, the rising of blood pressure moderate, lip sent out thread, eyelid or puffiness of face, take pharmaceutical composition of the present invention 1 day, and blood pressure recovers normal, after continuing to take 3 courses for the treatment of, condition.
The present invention finds that in a large amount of clinical practices it has the effect of significant treatment altitude sickness, and existing by main effect experiment, details are as follows:
(1), anoxia enduring experiment
1 experiment material
1.1 animal
Mice, male and female have both, and body weight is 18-22g.
Rearing conditions: after animal enters laboratory, separately, every cage puts 5 in a suitable place to breed to male and female, raises and enables after 3 days, by special messenger's feeding and management.Animal housing's illumination is sufficient, and heating ventilation and air-conditioning equipment is good, and room temperature controls at 20-25 DEG C, and humidity is 55-65%.Laboratory is regularly sterilized routinely.
1.2 medicine
Example 1 is prepared into tablet of the present invention, every 1g tablet is containing crude drug in whole 1.25g, the consumption of clinical tablet adult (70kg) of the present invention is 2-5g, get mediant 3.5g, Mouse oral dose,equivalent is 3.5/70g/kg × 35/3 ≈ 0.6g/kg, according to adult's clinical oral administration dosage, empirically the body surface area conversion factor of animals and human beings converts the dose,equivalent of animal to, then get 0.5,1,2 times amount as 3 dosage of laboratory animal administration, in table 2, dosage calculates by every kg body weight dosage (g/kg), be respectively 0.3,0.6,1.2g/kg.
Example 2 is prepared into capsule of the present invention, clinical capsule adult (70kg) consumption of the present invention is 3g, Mouse oral dose,equivalent is 3/70g/kg × 35/3=0.5g/kg, according to adult's clinical oral administration dosage, empirically the body surface area conversion factor of animals and human beings converts the dose,equivalent of animal to, then get 0.5,1,2 times amount as 3 dosage of laboratory animal administration.In table 3, dosage calculates by every kg body weight dosage (g/kg), be respectively 0.25,0.5,1g/kg.
Rhodiola rosea capsules, 0.38g/ grain, is produced by Radix Rhodiolae development center, Tibet Military Area Command, authentication code: the accurate word of army's medicine: Z2006001, lot number: 130301.Using Rhodiola rosea capsules as positive control drug (0.38g/ grain); Adult's usage and dosage: oral, 2 tablets/time, 2 times/day.By body surface area conversion, the dose,equivalent of mice is 0.205g/kg.
1.3 instruments and reagent
Wide mouthed bottle (125mL), stopwatch, vaseline, sodica calx, ether, Guangzhou Chemical Reagent Factory is produced.
2 methods and result
2.1 medicinal composition tablets of the present invention are on the impact of normal mouse normobaric hypoxia
Choose healthy mice 80, body weight 18-22g, male and female half and half, 5 groups are divided at random by body weight, sex, often organize 16, once, blank group gives normal saline to each treated animal gastric infusion every day, for three days on end, after last administration, 30min tests, and each group of mice is put into respectively the 125ml ground wide mouthed bottle (every bottle) filling 5g sodica calx, seals bottleneck with vaseline, cover tightly, make it air tight, immediately timing, with respiratory arrest position index, observe the time of mice death because of anoxia, the results are shown in Table 2.
Table 2 medicinal tablet of the present invention is on the impact (x ± s, n=16) of normal mouse normobaric hypoxia
| Group | Dosage (g/kg) | Time-to-live (s) |
| Compositions low dose group | 0.3 | 800.26±50.62 **# |
| Dosage group in compositions | 0.6 | 820.44±60.12 **## |
| Compositions high dose group | 1.2 | 898.63±70.55 **## |
| Rhodiola rosea capsules group | 0.205 | 706.20±51.03 * |
| Blank group | - | 620.41±46.32 |
Note: compare with blank group, * P < 0.05, * * P < 0.01; Compare with Radix Rhodiolae group, #P < 0.05, ##P < 0.01.
2.2 capsules of the present invention to be dehisced the impact of breathing time on mice broken end
Choose healthy mice 80, body weight 18-22g, male and female half and half, be divided into 5 groups at random by body weight, sex, often organize 16, once, blank group gives normal saline to each treated animal gastric infusion every day, and for three days on end, 1h after last administration, by mice by only breaking end; Breathing dwell time as anoxia enduring index by after stopwatch record mice broken end to dehiscing immediately, the results are shown in Table 3.
Table 3 capsule agent of the present invention to be dehisced the impact (x ± s, n=16) of breathing time on mice broken end
| Group | Dosage (g/kg) | Time-to-live (s) |
| Compositions low dose group | 0.25 | 24.52±4.56 * |
| Dosage group in compositions | 0.5 | 25.72±4.67 **# |
| Compositions high dose group | 1 | 26.13±5.06 **## |
| Rhodiola rosea capsules group | 0.205 | 24.61±4.43 * |
| Blank group | - | 18.25±3.46 |
Note: compare with blank group, * P < 0.05, * * P < 0.01; Compare with Radix Rhodiolae group, #P < 0.05, ##P < 0.01.
From above pharmacological testing, pharmaceutical composition energy significant prolongation anoxia in mice death time of the present invention and breathing time of dehiscing after breaking end, there is good resisting oxygen lack, give full play to the advantage of compositions Mutiple Targets, multipath effect, thus reach the object of control acute high altitude reaction.
The present invention can improve human body QO2; there is the function of cardioprotection, nerve and digestive system; preparation technology is simple, environmentally friendly; effectively can alleviate headache that altitude sickness causes, loss of appetite, asthenia, the symptom such as weak and dizzy; there is no toxic and side effects; for clinical prevention treatment altitude sickness disease, the various symptoms that alleviation altitude sickness causes provide one and newly select.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, various change can also be made under the prerequisite not departing from this patent aim.
Claims (7)
1. treat the pharmaceutical composition of altitude sickness medicine for one kind, it is characterized in that, be made up of the following raw material according to weight portion: Radix Glycyrrhizae 15-20 part, Cordyceps 5-10 part, Radix Rhodiolae 5-10 part, Radix Gentianae 3-8 part, Indigo Naturalis 2-4 part, acaulescent pegaeophyton herb 2-4 part, Caulis Spatholobi 2-4 part, Fructus Rhodomyrti 1-3 part, Luo Gaiye 1-3 part, Amiprol 0.2-0.6 part, meprobamate 0.2-0.6 part.
2. the pharmaceutical composition for the treatment of altitude sickness medicine according to claim 1, it is characterized in that, be made up of the following raw material according to weight portion: Radix Glycyrrhizae 16-18 part, Cordyceps 6-9 part, Radix Rhodiolae 6-9 part, Radix Gentianae 4-6 part, Indigo Naturalis 2.5-3.5 part, acaulescent pegaeophyton herb 2.5-3.5 part, Caulis Spatholobi 2.5-3.5 part, Fructus Rhodomyrti 1.5-2.5 part, Luo Gaiye 1.5-2.5 part, Amiprol 0.3-0.5 part, meprobamate 0.3-0.5 part.
3. the pharmaceutical composition for the treatment of altitude sickness medicine according to claim 1, it is characterized in that, be made up of the following raw material according to weight portion: 17 parts, Radix Glycyrrhizae, Cordyceps 8 parts, Radix Rhodiolae 8 parts, Radix Gentianae 5 parts, Indigo Naturalis 3 parts, acaulescent pegaeophyton herb 3 parts, Caulis Spatholobi 3 parts, Fructus Rhodomyrti 2 parts, Luo Gaiye 2 parts, Amiprol 0.4 part, meprobamate 0.4 part.
4. a preparation method for the pharmaceutical composition of the treatment altitude sickness medicine as described in as arbitrary in claim 1-3, it is characterized in that, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Radix Glycyrrhizae, Cordyceps, Radix Rhodiolae and Radix Gentianae are carried out grinding 5-6h and obtain mixed-powder;
(3) Indigo Naturalis, acaulescent pegaeophyton herb and Caulis Spatholobi are added the ethanol warm macerating 25-30min post-heating reflux, extract, twice of 60-65%, first time extracts 2.5-3h, and second time extracts 2-2.5h, has extracted rear merging extracted twice liquid, decompression recycling ethanol, after filtering, filtrate is for subsequent use;
(4) Fructus Rhodomyrti and Luo Gaiye are decocted with water twice, first time decocts 2-2.5h, and second time decocts 1.5-2h, and merge decoction liquor, the filtrate that step (3) obtains mixed homogeneously with decoction liquor after filtration, being concentrated into relative density is 1.23
-1.27, obtain extractum;
(5) mixed-powder added in Amiprol, meprobamate and step (2) mixes to extractum;
(6) add carrier, make described pharmaceutical composition finished product.
5. the preparation method of the pharmaceutical composition for the treatment of altitude sickness medicine according to claim 4, it is characterized in that, described carrier is one or more in xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, Cera Flava, allantoin, calcium stearate, magnesium stearate.
6. the preparation method of the pharmaceutical composition for the treatment of altitude sickness medicine according to claim 4, it is characterized in that, described pharmaceutical composition is tablet, capsule, oral liquid, suck agent, granule, pill, pellet, powder, mixture, drop pill, unguentum, injection, cream, spray, drop or patch.
7. one kind as arbitrary in claim 1-3 as described in the application of pharmaceutical composition in preparation treatment altitude sickness medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510902379.XA CN105434536A (en) | 2015-12-04 | 2015-12-04 | Medicine composition treating altitude stress and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510902379.XA CN105434536A (en) | 2015-12-04 | 2015-12-04 | Medicine composition treating altitude stress and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105434536A true CN105434536A (en) | 2016-03-30 |
Family
ID=55545470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510902379.XA Withdrawn CN105434536A (en) | 2015-12-04 | 2015-12-04 | Medicine composition treating altitude stress and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105434536A (en) |
-
2015
- 2015-12-04 CN CN201510902379.XA patent/CN105434536A/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102764340A (en) | Traditional Chinese medicine composite capable of improving sleep and preparation method and application thereof | |
| CN103405697A (en) | Medicament for treating pulmonary tuberculosis | |
| CN1210047C (en) | Medicine for treating common cold and preparation method | |
| CN106806853B (en) | Traditional Chinese medicine composition for relieving physical fatigue and/or improving anoxia endurance, preparation method and application thereof | |
| CN101579186B (en) | Pharmaceutical rhinitis pillow for external use and treating wind-heat rhinitis | |
| CN105412858A (en) | Syrup and preparation method thereof | |
| CN101284050B (en) | Corydalis tuber water soluble part medicament and its preparation method and application | |
| CN101933963B (en) | Nasal in-situ gel for treating headache | |
| CN102240341B (en) | Asthma-relieving dropping pill preparation method | |
| CN108465061A (en) | It is a kind of to be used to treat pharmaceutical composition of Facial Recurrent Dermatitis and its preparation method and application | |
| CN110755580B (en) | Traditional Chinese medicine composition with analgesic effect and application thereof | |
| CN107496525A (en) | A kind of Chinese medicine composition for treating cancer pain disease and its application | |
| CN104306649B (en) | A kind of medicament for the treatment of herpes zoster | |
| CN107854620B (en) | Traditional Chinese medicine composition for improving cognitive dysfunction after brain injury and application thereof | |
| CN105434536A (en) | Medicine composition treating altitude stress and preparation method and application thereof | |
| CN107137504B (en) | Health food for improving sleep and enhancing immunity | |
| CN101112504B (en) | Chinese medicine for curing cancer and the method for preparing the oral liquid thereof | |
| CN104491318A (en) | Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation | |
| CN103800844B (en) | A kind of pharmaceutical composition for the treatment of acute pancreatitis and preparation method thereof | |
| CN105998335A (en) | Tranquilizing traditional Chinese medicine composition gel and preparation method thereof | |
| CN107362296B (en) | Medicine for treating benign tumor of skin and preparation method thereof | |
| CN102670731B (en) | Traditional Chinese medicine preparation with analgesic activity and preparation method | |
| CN105031456A (en) | Traditional Chinese medicine prescription for relieving cough | |
| CN114949147A (en) | Traditional Chinese medicine composition for treating chronic pharyngitis as well as preparation method and application thereof | |
| CN113662980A (en) | Health foot bath composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160330 |