CN108938844A - Shegan Kangbingdu Injection by RP, preparation method and intravenously administrable Shegan Kangbingdu Injection by RP - Google Patents

Shegan Kangbingdu Injection by RP, preparation method and intravenously administrable Shegan Kangbingdu Injection by RP Download PDF

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CN108938844A
CN108938844A CN201710361148.1A CN201710361148A CN108938844A CN 108938844 A CN108938844 A CN 108938844A CN 201710361148 A CN201710361148 A CN 201710361148A CN 108938844 A CN108938844 A CN 108938844A
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weight
injection
parts
kangbingdu
shegan
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郑永刚
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The present invention relates to a kind of Shegan Kangbingdu Injection by RP, preparation method extremely intravenously administrable approach, belong to field of traditional Chinese medicine preparation.Its bulk pharmaceutical chemicals includes blackberry lily, honeysuckle, eupatorium, oriental wormwood, radix bupleuri, dandelion, Radix Isatidis, folium isatidis, wherein blackberry lily is 1~1000 parts by weight, honeysuckle is 1~1000 parts by weight, eupatorium is 1~1000 parts by weight, oriental wormwood is 1~1000 parts by weight, radix bupleuri is 1~1000 parts by weight, dandelion is 1~1000 parts by weight, Radix Isatidis is 1~1000 parts by weight, folium isatidis is 1~1000 parts by weight, the present invention is by by the crude drug steam distillation in prescription, boiling, add clarifying agent, alcohol precipitation, the multiple technologies means such as water is heavy obtain the effective active composition of Shegan Kangbingdu Injection by RP each component, by packing, sterilizing, obtain finished product preparation.Bioavilability of the present invention is high, and using simplicity, adverse reaction is few, avoids clinically inconvenient to use, and the medicine-feeding part pain of patient be easy to cause the adverse reactions such as hemostasis, even muscular death.

Description

Shegan Kangbingdu Injection by RP, preparation method and the antiviral note of intravenously administrable blackberry lily Penetrate liquid
Technical field
The present invention relates to a kind of Shegan Kangbingdu Injection by RP, preparation method and intravenously administrable Shegan Kangbingdu Injection by RP, Belong to field of traditional Chinese medicine preparation.
Background technique
Blackberry lily, alias crow fan, Wu Pu, ghost fan, wild tawny daylily flower, flat bamboo, golden butterfly etc., is penetrated for iris herbaceos perennial Dry dry rhizome；Property it is bitter, cold；Main component is belamcandin, tectoridin, tectorigenin, shekanin, blackberry lily alcohol etc..It penetrates Solid carbon dioxide decocting liquid has the function of resisting pathogenic microbes.
Honeysuckle, alias honeysuckle flowers, honeysuckle flower, little egret flower, Su Hua, golden flower, honeysuckle, Lonicera Japonica, two precious flowers, are Caprifoliaceae many years Raw half long green prehensile wooden this plant of Teng honeysuckle, lonicera hypoglauca miq, Honeysuckle flower or the dry flower of hair style honeysuckle or with just opening Flower；Property is sweet, cold；Contain volatile oil in spending, predominantly fragrant camphor tree alcohol, Eugenol, carvacrol, and contain chlorogenic acid, different green original Acid, ginkgolic acid, luteolin etc..Its Content of Chlorogenic Acid, isochlorogenic acid are the main antibiotic effective ingredients of honeysuckle, furthermore honeysuckle Extracting solution also has the function of anti-inflammatory, raising serum IgG antibody levels.
Eupatorium, alias fragrant thoroughwort, water perfume, great zeeland, Dou Lianglan, female orchid, vanilla, are the cauline leaf of compositae plant fragrant thoroughwort；Herb Containing volatile oil, predominantly to P-cymene, neryl acetate, Thymol methyl ether, leaf contains coumarin, o-coumaric acid, Moschus Careless quinhydrones, stigmasterol, palmitinic acid, taraxasterol, fumaric acid, succinic acid, mannitol etc. have antibacterial and resisiting influenza virus Effect.
Oriental wormwood, alias are compositae plant Artemisia capillaris or pig hair because of dirt, Ma Xian, Artemisia capillaris, spire sweet wormwood, artemisia hedinii, grandmother wormwood artemisia The tender seedling of wormwood artemisia；Herb contains escoparone, because of dirt wormwood artemisia flavones, capillarisin, and there are also Quercetin, Isorhamnetin and a variety of oriental wormwoods Derivative, chlorogenic acid of chromone etc. have the effects that resisting pathogenic microbes, antitumor.
Radix bupleuri, alias Asia puecon recklessly, smoke, rue wormwood artemisia, mountain dish, mushroom grass, faggot, HERBA BUPLEURI, for umbelliferae bupleurum, narrow leaf The root of radix bupleuri etc. mainly contains volatile oil, valeric acid, caproic acid, enanthic acid, Eugenol acetic acid vanillin ester, limonene in root, and contains bavin Hu saponin, polysaccharide etc., wherein saikosaponin saikoside or bupleurum Chinense volatile oil have anti-inflammatory effect.Radix bupleuri water decoction has disease-resistant original micro- in vitro The effect of biology, injection can inhibit epidemic hemorrhagic fever virus.
Dandelion, alias wild duck public affairs dish, Pu Gongcao, Chinese violet, Po Poding, dandelion, Pu Gongding, milk grass, Gu Guding are Compositae plant dandelion, alkali dandelion, different luxuriant dandelion etc. herb；Herb contains inositol, asparagine amaroid, saponin, Root such as taraxasterol, taraxerol, taraxacin and caffeic acid containing a variety of Triterpenoidss；With resisting pathogenic microbes, The effects of antitumor.
Radix Isatidis, alias indigo-blue, indigo root, indigo root are the root of cruciferae isatis, containing indigo, indigo is beautiful in root Red, indigo glycosides, sinigrin and a variety of amino acid have the effects that resisting pathogenic microbes, anticancer, adjusting are immune.
Folium isatidis is the leaf of cruciferae isatis, can be changed in leaf containing indigo, woaded blue glycosides, indigo red, the hydrolysis of woaded blue glycosides For indigo and furyl xylose ketone acid, have the function of resisting pathogenic microbes, antiendotoxin.
Visible the 20th WS3-B-3952- of ministry standard Traditional Chinese medicine historical preparation of existing Shegan Kangbingdu Injection by RP technique 98[preparation method] described in content；The Shegan Kangbingdu Injection by RP be the above group lease making distillation extract obtain volatile oil at Point, and obtain water soluble ingredient after water mentions and form, it is yellowish-brown or filemot clear liquid, there is antiviral and antibacterial anti-inflammatory Effect, can also be with other drugs with the use for the treatment of Hemorrhagic fever early stage illness.For intramuscular injection.Because being pure Chinese medicine system Agent, easily occurs that medical fluid is muddy, precipitating, metachromatism in preservation, influences product quality, validity period is only 2 years.
The present invention is easy to appear precipitating discoloration in placement process for the Shegan Kangbingdu Injection by RP in original technology Phenomena such as, by further technical treatment, obtain stability preferably Shegan Kangbingdu Injection by RP.
It is clinically inconvenient to use since the existing administration route of Shegan Kangbingdu Injection by RP is intramuscular injection, suffer from The medicine-feeding part pain of person, be easy to cause the adverse reactions such as extravasated blood, even muscular death.
It can be applied to intravenously administrable by the Shegan Kangbingdu Injection by RP that the bright technique of this law obtains, by intravenous drip or quiet Arteries and veins inject administration, bioavilability is high, and using simplicity, adverse reaction is few, and including direct intravenous injection, infusion medium includes Glucose injection, sodium chloride injection injection etc., are different from traditional similar injection.
Summary of the invention
The purpose of the present invention is to provide a kind of traditional Chinese medicines.
Another object of the present invention is to provide a kind of preparation methods of traditional Chinese medicine.
A further object of the present invention is to provide a kind of antiviral injections of intravenously administrable blackberry lily of Shegan Kangbingdu Injection by RP Liquid.
The present invention relates to a kind of Shegan Kangbingdu Injection by RP, preparation method and its intravenously administrable approach, belong to Chinese materia medica preparation Field.Its bulk pharmaceutical chemicals includes blackberry lily, honeysuckle, eupatorium, oriental wormwood, radix bupleuri, dandelion, Radix Isatidis, folium isatidis, and wherein blackberry lily is 1 ~1000 parts by weight, honeysuckle are 1~1000 parts by weight, eupatorium is 1~1000 parts by weight, oriental wormwood is 1~1000 parts by weight, bavin Act like a bully 1~1000 parts by weight, dandelion be 1~1000 parts by weight, Radix Isatidis is 1~1000 parts by weight, folium isatidis is 1~1000 Parts by weight, the present invention by crude drug steam distillation, boiling plus clarifying agent, alcohol precipitation, the water in prescription by sinking, being centrifuged, ultrafiltration Multiple technologies means obtain the effective active composition of Shegan Kangbingdu Injection by RP each component, by dispensing, sterilizing, obtain finished product system Agent.Injection of the invention has antiviral and antibacterial and anti-inflammation functions, can also go out with other drugs with the use for the treatment of popularity Blood-head early stage illness.Medical fluid is handled since preparation process uses multiple technologies means, obtained preparation has Phenomena such as avoiding to effect the muddy medical fluid occurred during traditional Chinese medicine injection storage, precipitating, discoloration, prolongs keeping life It is long.Technique can be administered by intravenous route through the invention, and bioavilability is high, and using simplicity, adverse reaction is few, avoids clinic Upper inconvenient to use, the medicine-feeding part pain of patient be easy to cause the adverse reactions such as extravasated blood, even muscular death.
The object of the invention can be achieved in the following manner:
Raw medicinal material and formula: blackberry lily, honeysuckle, eupatorium, oriental wormwood, radix bupleuri, dandelion, Radix Isatidis, folium isatidis are respectively 1- 1000 parts by weight, the parts by weight can be the conventional units such as mg, g, kg, jin, two, money, and preparation method includes following step It is rapid:
(1) water of 3-6 times of weight of raw medicinal material weight is added, collects distillate with steam distillation, distillate is subjected to weight Distillation, obtains that smart to slip liquid spare；
(2) 4~6 times of weight of dregs of a decoction dosing material of water boiling after distillation is decocted at least 2 times, it is 1-2 hours each, it filters, closes And filtrate, filtrate are concentrated twice,
(3) 0.03%~0.06% clarifying agent of concentrate weight is added into concentrate, is heated to 70~90 DEG C, stands Afterwards, 0.015%~0.03% clarifying agent of concentrate weight is added, is stood, centrifugation takes supernatant to be concentrated；
(4) it is slowly stirred lower addition ethyl alcohol, adds ethanol precipitation, is filtered after refrigeration, filtrate recycling ethanol, and be concentrated, add second Alcohol filters after refrigeration, and simultaneously filtrate is concentrated in filtrate recycling ethanol；
(5) water for injection for adding 1-3 times of weight of concentrate, is filtered after refrigeration, and filtrate is adjusted with 10-20% sodium hydroxide solution PH to 5.0-7.0 is added 1% active carbon, boils, filtering, and above-mentioned essence is added in filtrate and slips liquid, is uniformly mixed, and heating is let cool It refrigerating 24 hours, is centrifuged with centrifuge afterwards, take supernatant, water for injection is added in ultrafiltration, and filtering is filling in ampoule, sterilizing, Packaging.
1/6~1/4 that distillate is medicinal material amount is collected in above-mentioned steps after steam distillation, distillate is subjected to redistillation Afterwards smart 1/8~1/6 for slipping liquid and being about medicinal material weight.
After clarifying agent is added for the first time, after standing 2 hours, second standing 4 hours.
Supernatant after adding clarifying agent is concentrated into every ml medical fluid 3~4g containing crude drug amount.
Ethyl alcohol is added for the first time makes alcohol content 70-75%, and 4-8 DEG C refrigerates 48 hours, filter paper filtering, filtrate recycling ethanol After be concentrated into every ml medical fluid 3~4g containing crude drug amount, second, which is added ethyl alcohol, makes alcohol content 80-85%, and 4-8 DEG C to refrigerate 48 small When, filter paper filtering, filtrate recycling ethanol is concentrated filtrate, and is concentrated into every ml medical fluid 6~8g containing crude drug amount.
After the water for injection of 1-3 times of weight of concentrate is added, 4-8 DEG C is refrigerated 24 hours, filter paper filtering, after filtrate adjusts PH If desired, 1% active carbon is added, boil 30 minutes, filter paper filtering, above-mentioned essence is added in filtrate and slips liquid, is uniformly mixed, 105 DEG C are heated 45 minutes, are let cool, and 4-8 DEG C refrigerates 24 hours, and centrifugation takes supernatant ultrafiltration, and water for injection is added, and filtering is filling In ampoule, 100 DEG C sterilize 30 minutes.
It can be seen from the above description that water described in the present invention sinks to recycle the concentration filtrate obtained after ethyl alcohol to alcohol precipitation Middle addition water for injection.
Clarifying agent in above-mentioned preparation method is for granularity the greater in only removing Aqueous extracts and with precipitating trend Suspended particulate can retain effective polymer substance, so that the clarifying agent of the stability of medical fluid is improved, it is including but not limited to existing There are the various clarifying agents that can be used in Chinese medicine in technology, such as commercially available 101 fruit juice clarifier, chitin kind absorptive clarificant, ZTC days Right clarifying agent clarification and clarifying agent B, clarifying agent A etc..
More specifically, Shegan Kangbingdu Injection by RP of the present invention the preparation method comprises the following steps: being prepared according to above-mentioned medicinal material formula former Expect medicinal material, it is the 1/6~1/ of medicinal material amount that the purified water that 3-6 times of weight of medicinal material weight is added, which collects distillate with steam distillation, 4, distillate is subjected to redistillation, obtains smart 1/8~1/6 for slipping liquid and being about medicinal material weight, it is spare；By the dregs of a decoction dosing material after distillation 4~6 times of weight of purifying water boiling decocts 2 times, 1-2 hour each, and filter paper filtering merges filtrate twice, and filtrate is concentrated, to dense 0.03%~0.06% clarifying agent B of concentrate weight is added in contracting liquid, is heated to 70~90 DEG C, after standing 2 hours, then plus Enter the clarifying agent A of the 0.015%~0.03% of concentrate weight, after standing 4 hours, centrifugation, supernatant is poured out, and is concentrated into every Ml medical fluid 3~4g containing crude drug amount；It is slowly stirred lower addition ethyl alcohol, ethyl alcohol is added to make alcohol content 70-75%, 4-8 DEG C of refrigeration 48 is small When, filter paper filtering, filtrate recycling ethanol, and it is concentrated into every ml medical fluid 3~4g containing crude drug amount, ethyl alcohol is added, makes alcohol content 80- 85%, 4-8 DEG C refrigerate 48 hours, and filtrate is concentrated in filter paper filtering, filtrate recycling ethanol, and are concentrated into every ml medical fluid containing crude drug amount 6 ~8g；Add the water for injection of 1-3 times of weight of concentrate, 4-8 DEG C refrigerates 24 hours, filter paper filtering, filtrate 10-20% hydroxide Sodium solution adjusts PH to 5.0-7.0, and 1% active carbon is added, boils 30 minutes, filter paper filtering, and above-mentioned essence is added in filtrate and slips Liquid is uniformly mixed, and is heated 45 minutes, is let cool at 105 DEG C, and 4-8 DEG C refrigerates 24 hours, is centrifuged with centrifuge, takes supernatant, is surpassed Water for injection is added in filter, and filtering is filling in ampoule, and 100 DEG C sterilize 30 minutes.
Resulting product specification is 2ml/ branch, 5ml/ branch, 10ml/ branch, 20ml/ branch, preferably 2ml/ branch, 5ml/ branch, 10ml/ Branch, every ml (C containing chlorogenic acid16H18O9) it is to be no less than 0.5mg, preferably every ml (C containing chlorogenic acid16H18O9) it is 0.5~20mg.
In preparation process, clarifying agent be it is commercially available, to make technique, stable product quality, clarifying agent B, clarifying agent A are by fixing life Business men provides.Above-mentioned clarifying agent purchased from the positive day in Tianjin at clarification technique Co., Ltd, there are two types of models, be denoted as clarifying agent A, Clarifying agent B.
When injection of the present invention uses by the way of intravenous injection, bioavilability is high, uses simplicity, adverse reaction It is few.Injection system may is that intramuscular injection, a 2ml~5ml, 3 times a day；Intravenous drip, a 10ml~15ml, one day Once, it is added in 5% glucose injection of 250ml~500ml, 10% glucose injection or 0.9% sodium chloride injection It slowly instils, or follows the doctor's advice.
Injection of the present invention increases the stability of preparation under the premise of with good drug effect, effectively avoids biography Phenomena such as degradation that system injection occurs in long-term storage, muddiness, precipitating, extend the quality of blackberry lily antiviral drugs preparation Validity period；And reach and can be administered with intravenous route, bioavilability is high, and using simplicity, adverse reaction is few, avoids clinically making With inconvenience, the medicine-feeding part pain of patient, reduction causes the adverse reactions such as extravasated blood, even muscular death.
Specific embodiment
Embodiment 1
Take blackberry lily 500g, honeysuckle 400g, eupatorium 300g, oriental wormwood 200g, radix bupleuri 150g, dandelion 250g, Radix Isatidis 400g, big Leafiness 300g, it is the 1/5 of medicinal material amount that the purified water that 3 times of weight of medicinal material weight is added, which collects distillate with steam distillation, will Distillate carries out redistillation, obtains smart 1/8 for slipping liquid and being about medicinal material weight, spare；By 5 times of weight of dregs of a decoction dosing material after distillation It purifies water boiling to decoct 2 times, 1 hour every time, filter paper filtering merged filtrate twice, and concentration is added into concentrate for filtrate concentration The clarifying agent B of the 0.06% of liquid weight is heated to 70~90 DEG C, after standing 2 hours, adds the 0.03% of concentrate weight Clarifying agent A, after standing 4 hours, centrifugation, supernatant is poured out, and is concentrated into every ml medical fluid 4g containing crude drug amount；It is slowly stirred lower addition Ethyl alcohol adds ethyl alcohol to make alcohol content 70%, and 4-8 DEG C refrigerates 48 hours, filter paper filtering, filtrate recycling ethanol, and is concentrated into every ml Ethyl alcohol is added in medical fluid 4g containing crude drug amount, makes alcohol content 80%, and 4-8 DEG C refrigerates 48 hours, filter paper filtering, filtrate recycling ethanol, Filtrate is concentrated, and is concentrated into every ml medical fluid 6g containing crude drug amount；Add the water for injection of 2.5 times of weight of concentrate, 4-8 DEG C of refrigeration 24 is small When, filter paper filtering, filtrate adjusts PH to 5.5 with 10% sodium hydroxide solution, 1% active carbon is added, boils 30 minutes, filter paper It filters, above-mentioned essence is added in filtrate and slips liquid, be uniformly mixed, heat 45 minutes, let cool at 105 DEG C, 4-8 DEG C refrigerates 24 hours, uses Centrifuge centrifugation takes supernatant, and ultrafiltration, water for injection, which is added, makes every ml (C containing chlorogenic acid16H18O9) it is 1.6mg, filtering is filling In ampoule, 100 DEG C sterilize 30 minutes.
Resulting product specification is 2ml/ branch, 5ml/ branch.
Embodiment 2
Take blackberry lily 50g, honeysuckle 900g, eupatorium 100g, oriental wormwood 300g, radix bupleuri 150g, dandelion 250g, Radix Isatidis 100g, big Leafiness 200g, it is the 1/6 of medicinal material amount that the purified water that 2 times of weight of medicinal material weight is added, which collects distillate with steam distillation, will Distillate carries out redistillation, obtains smart 1/7 for slipping liquid and being about medicinal material weight, spare；By 6 times of weight of dregs of a decoction dosing material after distillation It purifies water boiling to decoct 2 times, 1 hour every time, filter paper filtering merged filtrate twice, and concentration is added into concentrate for filtrate concentration The clarifying agent B of the 0.04% of liquid weight is heated to 70~90 DEG C, after standing 2 hours, adds the 0.02% of concentrate weight Clarifying agent A, after standing 4 hours, centrifugation, supernatant is poured out, and is concentrated into every ml medical fluid 3g containing crude drug amount；It is slowly stirred lower addition Ethyl alcohol adds ethyl alcohol to make alcohol content 75%, and 4-8 DEG C refrigerates 48 hours, filter paper filtering, filtrate recycling ethanol, and is concentrated into every ml Ethyl alcohol is added in medical fluid 3g containing crude drug amount, makes alcohol content 85%, and 4-8 DEG C refrigerates 48 hours, filter paper filtering, filtrate recycling ethanol, Filtrate is concentrated, and is concentrated into every ml medical fluid 8g containing crude drug amount；Add the water for injection of 3 times of weight of concentrate, 4-8 DEG C of refrigeration 24 is small When, filter paper filtering, filtrate adjusts PH to 6.0 with 10% sodium hydroxide solution, 1% active carbon is added, boils 30 minutes, filter paper It filters, above-mentioned essence is added in filtrate and slips liquid, be uniformly mixed, heat 45 minutes, let cool at 105 DEG C, 4-8 DEG C refrigerates 24 hours, uses Centrifuge centrifugation takes supernatant, and ultrafiltration, water for injection, which is added, makes every ml (C containing chlorogenic acid16H18O9) be 10mg, filtering, it is filling in In ampoule, 100 DEG C sterilize 30 minutes.
Resulting product specification is 2ml/ branch, 5ml/ branch.

Claims (2)

1. a kind of Shegan Kangbingdu Injection by RP, by by prescription crude drug steam distillation, boiling plus clarifying agent, alcohol precipitation, Water is heavy, be centrifuged, ultrafiltration multiple technologies means obtain the effective active composition of Shegan Kangbingdu Injection by RP each component, by dispensing, Sterilizing, obtains finished product preparation, wherein raw medicinal material and formula: blackberry lily, honeysuckle, eupatorium, oriental wormwood, radix bupleuri, dandelion, plate are blue Root, folium isatidis are respectively 1-1000 parts by weight.
2. injection according to claim 1, it is characterised in that the every ml of Shegan Kangbingdu Injection by RP contains chlorogenic acid (C16H18O9) it is no less than 0.5mg.
CN201710361148.1A 2017-05-22 2017-05-22 Shegan Kangbingdu Injection by RP, preparation method and intravenously administrable Shegan Kangbingdu Injection by RP Pending CN108938844A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109549993A (en) * 2018-12-29 2019-04-02 西安高科陕西金方药业公司 Rectum or nebulizer administration blackberry lily anti-virus formulation and preparation and purposes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109549993A (en) * 2018-12-29 2019-04-02 西安高科陕西金方药业公司 Rectum or nebulizer administration blackberry lily anti-virus formulation and preparation and purposes

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Application publication date: 20181207