CN108925570A - A kind of composite bactericide - Google Patents
A kind of composite bactericide Download PDFInfo
- Publication number
- CN108925570A CN108925570A CN201710395585.5A CN201710395585A CN108925570A CN 108925570 A CN108925570 A CN 108925570A CN 201710395585 A CN201710395585 A CN 201710395585A CN 108925570 A CN108925570 A CN 108925570A
- Authority
- CN
- China
- Prior art keywords
- picarbutrazox
- bacterium amine
- azoles bacterium
- suspending agent
- composite bactericide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/713—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to technical field of pesticide, it is related to a kind of composite bactericide, it is characterized in that containing fluorine indenes azoles bacterium amine and picarbutrazox two kinds of active components, the composition can be configured to the dosage forms such as suspending agent, microemulsion, microcapsule suspending agent, suspension seed-coating agent, wettable powder, water dispersible granules, dispersible oil-suspending agent, with apparent synergistic effect, lasting period is long, environmentally friendly.
Description
Technical field
The invention belongs to technical field of pesticide, are related to the compound sterilizing of a kind of fluorine-containing indenes azoles bacterium amine and picarbutrazox
Agent.
Background technique
Fluorine indenes azoles bacterium amine chemical name：3- difluoromethyl-N- (the fluoro- 2,3- dihydro -1,1,3- trimethyl -1H- indenes -4- of 7-
Base) -1- methyl-1 H- pyrazole-4-carboxamide, belong to wide spectrum SDHI class fungicide, fungicidal spectrum covers all thifluzamides and Lu Na
Gloomy fungicidal spectrum, in addition to Rhizoctonia solani special efficacy, all to anthrax, rust, early blight, powdery mildew, leaf mold, false smut preventive effect
Very well.It will be high than Lu Nasen, green prince wife's activity especially in terms of powdery mildew.Structural formula is as follows：
Picarbutrazox test code number is NF-171, and the carbamate fungicide of Japanese Cao Da company exploitation is changed
Scientific name claims：[6- [[(Z)-(1- methyl-1 H-5- tetrazole radical) (phenyl) methylene)] aminooxymethyl] -2- pyridyl group] amino first
Tert-butyl acrylate has preferable control efficiency to downy mildew and epidemic disease.
Since various regions pesticide abuse causes resistance increasing, the lasting raising of the dosage of pesticide.However larger dose
Pesticide abuse causes to make havoc of environment, does not also play due effect well.Pass through our a large amount of field medicines
Effect test discovery, the mixed generation that can be very good delaying drug resistance of pesticide improve drug effect, to reduce the usage amount of pesticide.
Due to the use lack of standardization of current pesticide, causes disease more and more stronger to the resistance of pesticide, causes Pesticide use amount higher and higher,
Cause the pollution of environment.Show to compound fluorine indenes azoles bacterium amine with picarbutrazox by our experimental study, one
Determine that there is apparent synergistic effect in range, can be good at overcoming the shortcomings of existing product, improve drug effect, reduce usage amount,
It increases economic efficiency.
Summary of the invention
The object of the present invention is to provide a kind of composite bactericide with synergistic effect and safety and environmental protection, with existing prevention and treatment medicine
Agent is compared, and realizes the purpose for improving drug effect, extending the lasting period, reduce pollution, reducing cost.More particularly to fluorine indenes azoles bacterium amine and
The composite bactericide of picarbutrazox.
In above-mentioned composite bactericide, the weight ratio of fluorine indenes azoles bacterium amine and picarbutrazox are 1:50~50:1, it is preferably heavy
Amount is than being 1：30~30：1, more preferable weight ratio is 1：10~10：1.
Using bactericidal composition of the present invention, it is equipped with auxiliary agent known to those skilled in the art, in the art
Dosage form according to the present invention is made in method well known to technical staff：Suspending agent, microemulsion, microcapsule suspending agent, suspended seed coating
Agent, wettable powder, water dispersible granules, dispersible oil-suspending agent.
The advantages of above-mentioned composite bactericide：1. fluorine indenes azoles bacterium amine belongs to novel environment friendly fungicide, bactericidal effect is strong, and two kinds are killed
The microbial inoculum mode of action has complementarity；2. selected dosage form safety, effect on environment is low, can be good at playing drug effect；③
For two kinds of ingredients without apparent cross resistance, effective component is novel, and the mode of action is unique, and bactericidal effect is strong, is not likely to produce drug resistance；
4. two kinds of ingredient compoundings, there is good synergistic effect.
Above-mentioned composite bactericide is suitable for crop disease control, can be used for preventing and treating powdery mildew, downy mildew, scab, leaf
Pinta, rice blast, banded sclerotial blight, late blight, damping-off, gray mold etc..
Specific embodiment
For the synergistic effect of verifying two kinds of effective component of fluorine indenes azoles bacterium amine and picarbutrazox compounding, applicant is first
Indoor biometrics experiment is carried out using both ingredients, test method and result are as follows：
After the action character for analyzing two kinds of effective component first, the raw object surveyed is set to Cuba artificial downy mildew by us
(Pseudoperonospora cubensis), the Pseudomonas Mastigomycotina fungi, can cause the downy mildew of cucumber.
The test method of indoor biometrics：Using plate blade method measurement medicament to the bioactivity of bacterium of downy mildew of cucumber.Choosing
With cucumber susceptible variety potting, 4 leaf positions~6 leaf positions from up to down, clip same area, growing way are consistent, have 1cm~2cm leaf
The blade of handle is placed in culture dish with wet cotton balls package petiole, and moisturizing is spare.Incidence of leaf is selected, under being washed with 4 DEG C of distillations
Vacuum side of blade downy mildew sporangium, being made into suspension, (concentration controls every milliliter 1 × 105A~1 × 107A sporangium), 4 DEG C
Lower storage is spare.95% fluorine indenes azoles bacterium amine raw medicine and 96%picarbutrazox raw medicine dissolved with methanol, is spat with 0.05%
Warm 80 aqueous solutions dilution.According to agent activity, 5~7 series mass concentration are set, the final content of organic solvent is no more than 1%.
Then medical fluid is uniformly sprayed on vacuum side of blade, after medical fluid natural air drying, by each processing blade and blade backwards to upper, by processing label
After be emitted in moisture preservation box.Test assume thats the treatment without medicament is a blank control.With ready Fresh spores capsule suspension point
10 microlitres of drop is inoculated in vacuum side of blade, and every blade inoculation 4 drips, and every processing is no less than 5 leaves.It is inoculated with, connects for 24 hours after pharmaceutical treatment
Ware lid is covered after kind, is placed in growth cabinet, in daily continuous illumination/dark 12h alternating, temperature is 17 DEG C~22 DEG C, phase
To being cultivated under conditions of 90% or more humidity.Record lesion diameter is measured depending on blank control incidence, and calculates control efficiency.
The EC of each medicament is calculated as regression analysis according to each drug concentration logarithm and corresponding preventive effect probit value50。
The co-toxicity of mixture preparation is indicated using the co-toxicity coefficient method of Sun Yunpei：
The mixture preparation theoretical toxicity index TTI=∑ (pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture
Percentage).
Co-toxicity coefficient CTC is synergistic effect when being greater than 120, is antagonism when less than 80, is when between 80-120
Addition.
The survey of 1 fluorine indenes azoles bacterium amine of table and picarbutrazox and its different ratio to cucumber downy mildew germ co-toxicity coefficient
Determine result
Analyze above-mentioned data, it can be clearly seen that when fluorine indenes azoles bacterium amine and picarbutrazox are compounded in varing proportions, match
The co-toxicity coefficient (CTC) of side is all larger than 120, has the synergistic effect of different proportion to the prevention and control capability of cucumber downy mildew, works as fluorine
Indenes azoles bacterium amine and picarbutrazox are 1：10~10：When 1, co-toxicity coefficient (CTC) is all larger than 136, and synergistic effect is more aobvious
It writes.
By indoor biometrics experiment, verifying two kinds of effective component compoundings of fluorine indenes azoles bacterium amine and picarbutrazox can have
Good synergistic effect, the following specific examples are used to further explain the present invention in detail, but the present invention is only limited to absolutely not
These embodiments below.Percentage is weight percentage in formula, and used raw medicine and auxiliary agent are that other producers provide.
Formulation examples are as follows：
Example 1：25.5% fluorine indenes azoles bacterium amine picarbutrazox suspending agent
Example 2：31% fluorine indenes azoles bacterium amine picarbutrazox wettable powder
Example 3：Oil-suspending agent can be dispersed in 21% fluorine indenes azoles bacterium amine picarbutrazox
Example 4：11% fluorine indenes azoles bacterium amine picarbutrazox suspension seed-coating agent
Example 5：12% fluorine indenes azoles bacterium amine picarbutrazox suspending agent
Example 6：20% fluorine indenes azoles bacterium amine picarbutrazox water dispersible granules
Example 7：18% fluorine indenes azoles bacterium amine picarbutrazox suspending agent
Example 8：11% fluorine indenes azoles bacterium amine picarbutrazox suspension seed-coating agent
Example 9：21% fluorine indenes azoles bacterium amine picarbutrazox water dispersible granules
Example 10：31% fluorine indenes azoles bacterium amine picarbutrazox suspending agent
Example 11：25.5% fluorine indenes azoles bacterium amine picarbutrazox suspending agent
Test two：Selection above example carries out the field trial of prevention and treatment cucumber downy mildew, determines formula prevention and treatment cucumber downy mildew
Disease effect, while by with 5% fluorine indenes azoles bacterium amine suspending agent (dosage form English name：SC), 10%picarbutrazox suspends
Agent (dosage form English name：SC) the Contrast on effect of single dose verifies the control efficiency of the embodiment of the present invention.Test each processing four
It repeats, the random district's groups arrangement of cell processing, each plot area is 30m2, investigation method is：Every cell is using 4 points of samplings, often
2~3 plants of point investigation, the whole blades of every plant of investigation, calculates sick leaf rate.
Calculation method：According to Disease investigation data, the disease index and control efficiency of each processing are calculated.
The preventive effect of 2 fluorine indenes azoles bacterium amine of table and picarbutrazox suspending agent and different agents to cucumber downy mildew
It is seen from the above data that 7 days preventive effects to cucumber downy mildew compare fluorine more than 85% after compound preparation medicine
Two kinds of single doses of indenes azoles bacterium amine and picarbutrazox, compound preparation preventive effect highly significant；14 days after medicine, compound preparation preventive effect
More than 88%, it is seen that two kinds of effective component compoundings have good synergistic effect, extend the lasting period, prevent cucumber downy mildew
It is more longlasting to control effect.
In conclusion fluorine indenes azoles bacterium amine and picarbutrazox are compounded, compound preparation is applied in crops,
Can not only controlling disease, improve drug effect, extend the lasting period, and mitigate peasant the amount of labour, have very high practicability.This hair
It is bright it is implementable and it is unobvious violate the present invention under the premise of, can be appointed between technical characteristic described in different technologies scheme
Meaning form combines and forms other technologies scheme.The above specific embodiment and embodiment have been carried out specifically to the present invention
It is bright, but be not intended to limit the scope of the present invention, it modifies and replaces in the principle without departing from claim, should all belong to
In in protection scope of the present invention.
Claims (5)
1. a kind of composite bactericide, it is characterised in that：Active constituent is made of fluorine indenes azoles bacterium amine and picarbutrazox, described
The weight ratio of fluorine indenes azoles bacterium amine and picarbutrazox are 1：50~50：1.
2. composite bactericide according to claim 1, it is characterised in that：The weight of fluorine indenes azoles bacterium amine and picarbutrazox
Amount is than being 1：30~30：1.
3. composite bactericide according to claim 1, it is characterised in that：The weight of fluorine indenes azoles bacterium amine and picarbutrazox
Amount is than being 1：10~10：1.
4. composite bactericide according to claim 1, it is characterised in that：Suspending agent, micro- is made by active constituent and auxiliary material
Emulsion, microcapsule suspending agent, suspension seed-coating agent, wettable powder, water dispersible granules, dispersible oil-suspending agent.
5. composite bactericide according to claim 1, for preventing and treating powdery mildew, downy mildew, scab, leaf spot, rice blast
Disease, banded sclerotial blight, late blight, damping-off, gray mold etc..
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710395585.5A CN108925570A (en) | 2017-05-27 | 2017-05-27 | A kind of composite bactericide |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710395585.5A CN108925570A (en) | 2017-05-27 | 2017-05-27 | A kind of composite bactericide |
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| Publication Number | Publication Date |
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| CN108925570A true CN108925570A (en) | 2018-12-04 |
Family
ID=64448357
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710395585.5A Pending CN108925570A (en) | 2017-05-27 | 2017-05-27 | A kind of composite bactericide |
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| CN (1) | CN108925570A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103502220A (en) * | 2010-12-20 | 2014-01-08 | I-F产品协作基金会 | Aminoindanes amides having a high fungicidal activity and phytosanitary compositions thereof |
| CN104602523A (en) * | 2012-06-15 | 2015-05-06 | I-F产品协作基金会 | Synergistic compositions for the protection of agrarian crops and the use thereof |
| CN106689161A (en) * | 2016-12-20 | 2017-05-24 | 东莞市瑞德丰生物科技有限公司 | Picarbutrazox-containing bactericidal composition |
-
2017
- 2017-05-27 CN CN201710395585.5A patent/CN108925570A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103502220A (en) * | 2010-12-20 | 2014-01-08 | I-F产品协作基金会 | Aminoindanes amides having a high fungicidal activity and phytosanitary compositions thereof |
| CN104602523A (en) * | 2012-06-15 | 2015-05-06 | I-F产品协作基金会 | Synergistic compositions for the protection of agrarian crops and the use thereof |
| CN106689161A (en) * | 2016-12-20 | 2017-05-24 | 东莞市瑞德丰生物科技有限公司 | Picarbutrazox-containing bactericidal composition |
Non-Patent Citations (1)
| Title |
|---|
| 张炎光等: "《蔬菜病虫害无公害防治》", 31 January 2004 * |
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Application publication date: 20181204 |
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