CN108904671A - A kind of health protection tea and its preparation method and application of bidirectional modulation blood glucose - Google Patents
A kind of health protection tea and its preparation method and application of bidirectional modulation blood glucose Download PDFInfo
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- CN108904671A CN108904671A CN201810770154.7A CN201810770154A CN108904671A CN 108904671 A CN108904671 A CN 108904671A CN 201810770154 A CN201810770154 A CN 201810770154A CN 108904671 A CN108904671 A CN 108904671A
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- health protection
- tea
- protection tea
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Abstract
The present invention relates to a kind of prevention or the health protection teas of adjuvant treatment diabetes, it has the function of bidirectional modulation blood glucose, and also has the function for the treatment of the skin infection of refractory conjunction and wound.The health protection tea of the application is by including that the raw materials such as 10-30 parts by weight vine tea, 10-30 parts by weight peony, 10-30 parts by weight Chinese yam, 1-5 parts by weight Cordyceps militaris are prepared.The preparation of the health protection tea takes full advantage of the bioconversion function of cordyceps mycelium, and the active constituent in bulk pharmaceutical chemicals has been converted to absorb more preferable, the higher product of activity, has obtained unexpected therapeutic effect.
Description
Technical field
The present invention relates to a kind of preventions or the health composition of adjuvant treatment diabetes, the composition to have bidirectional modulation blood
The function of sugar, and also have the function for the treatment of the skin infection of refractory conjunction and wound.
Background technique
The disease incidence of diabetes increases year by year, is shown according to epidemic data in 2013, Chinese adult patient of diabetes
Sick rate is 11.6%, and the illness rate of prediabetes is up to 50.1%.The cardinal symptom of diabetic is that blood sugar concentration is higher than
Normal range (NR), however development and medicine since existing hypoglycemic medicine and health care product all can only unidirectionally reduce blood glucose, with the state of an illness
The uncontrollability of object treatment, that there are blood glucose levels is unstable, fluctuated by many diabetics, or hypoglycemia occurs
Symptom.The lower glycemic control not the better, recently the study found that hypoglycemia is bigger than the harm of hyperglycemia.When hyperglycemia is short-term
In will not injure the life of people, and the harm of hypoglycemia be rapidly, especially the elderly due to perception it is weaker, seriously
When probably because hypoglycemic reaction cause stupor even it is fatal.So should to control blood glucose excessively high by diabetic, also to mention
Anti- hypoglycemia, as far as possible holding body blood glucose reach a kind of stable state.Currently, unstable for diabetes blood glucose and simultaneously
The prevention and treatment of hypoglycemia are sent out, can only increase the modes such as the number of blood sugar monitoring using diet, movement is adjusted and carry out, however
Since trouble, effect are unobvious, palliative, patient is often difficult to adhere to above-mentioned means, therefore produces effects less.
In addition, existing treatment diabetes drugs and health products can not prevent the development of the complication of diabetes, especially
It is that the certain primary or secondary skin wounds of diabetes patient are difficult to heal, and brings greatly pain and life to these patients
Inconvenience living.Common people's wound can voluntarily recover within one to two week, but diabetic, lack and voluntarily repair wound ability,
In addition blood glucose is high, increase bacterium infection chance, incipient diabetic patient, wound can just recover after one or two possible moon, long
Phase patient also fails to recover, and has diffusive infection situation for wound possibility three months or more.Diabetic once bursts accidentally
Ulcer is easy to cause wound that cannot recover since body hyperglycemia and resistivity are low, or even severe infections occurs and must be cut
Except foot surgery, to save life.It is more passive that current diabetic receives treatment, including clears up ulcer wound, takes antibiosis
Plain anti-inflammatory periodically controls blood sugar concentration, protects wound and anti-inflammatory using the dressing of external application, and carrying out excision hand to severe infections person
Art.It is a kind of common complication that diabetes, which often result in skin ulcer, especially foot ulcers, in all diabetics about
15% goes out foot ulcers in their a certain stage developments of life, see, for example, Jeffccoate, W&Harding, K.,
2003.Diabetic Foot Ulcers.TheLancet, 362；154-51, entire contents are incorporated by reference into the application
In.And diabetes are treated at present mainly using external drug, it prevents from feeling using activating microcirculation and removing stasis medicinal and clearing heat and detoxicating equal drugs
Dye and promotion wound healing, but dressing is troublesome and treatment cycle is longer；Although there are also oral medication sugar in the prior art
The drug of foot disease is urinated, Chinese medicine is generally taken the constitution medicine typing according to patient, is treated respectively for this kind of patients, but
It is that this method universality is poor, is unfavorable for promoting and applying.Such as CN106389952A, CN106110109A, but they or
The tonifying Qi drug such as Radix Astragali, ginseng etc. of large dosage is given based on deficient qi and blood, or based on the clearing heat and detoxicating soil for giving large dosage
The drugs such as Poria cocos, Patrinia scaniosaefolia, kuh-seng, but in addition to the patient with diabetic feet of deficiency of vial QI, many patients also have hyperlipidemia, height simultaneously
Much there is the case where liver-yang hyperactivity in the patient of blood pressure, hyperlipidemia, the hypertension state of an illness can be aggravated by taking this kind of tonifying Qi drug；Also
There are many patients weakness of the spleen and the stomach, the cold and cool drug for taking large dosage will lead to serious adverse reaction, therefore existing product is still
It is not able to satisfy vast diabetes human needs.
Technology contents
The present inventor passes through unremitting effort and creative labor, grinds to the state of an illness of the diabetes patient of different diseases
Study carefully, find the diabetes patient of whether which kind of constitution, all there is the unbalanced state of yin-yang in body, it is lower burnt that part of the body cavity above the diaphragm housing the heart and lungs Sheng heat is presented
The symptom of the cold of insufficiency type gives merely the drug then easy excessive internal heat of patient of yang-tonifying, and giving clearing heat and detoxicating drug merely, then patient is easy again
There are the symptoms such as diarrhea, cold.The unbalanced situation of yin-yang in diabetes patient's body in order to adjust different constitutions simultaneously,
It allows body to reach the balance of energy, helps to improve the vis medicatrix naturae of diabetes patient's body, inventor carries out a large amount of drug
Further investigation, and carried out the research of a large amount of compatibility, preparation method.Finally it is prepared for health protection tea of the invention.The tea be by
The raw materials such as vine tea, peony, Chinese yam, Cordyceps militaris are prepared by modern biotechnology transformation technology, and rose can also be added
Rare, cape jasmine, chrysanthemum, cortex cinnamomi.Wherein vine tea has the function of that clearing heat and promoting diuresis, calming the liver are depressured, are promoting blood circulation and removing obstruction in channels；Peony has promoting blood circulation
The effect of menstruation regulating；Lung, reinforce the kidney beneficial essence are supported in Chinese yam tonifying Qi；Cordyceps militaris can tonifying lung yin and kidney-replenishing, being unique kind can put down simultaneously
Weighing apparatus, the Chinese medicine for adjusting yin-yang；Rose has the function of regulating the flow of vital energy and dispeling melancholy, activating microcirculation and removing stasis medicinal；Cape jasmine has clearing heat and promoting diuresis, purging intense heat relieving restlessness
Effect；Chrysanthemum has the function of relieve heat heat-clearing, clears liver and improve vision；Cortex cinnamomi has the function of mends fire supporing yang, let the fire back to its origin.In the application
Composition in, vine tea, cape jasmine have the function of heat-clearing, can remove extra hot and suffocating of the part of the body cavity above the diaphragm housing the heart and lungs, chrysanthemum can assist stagnation of heat in upper-JIAO
Diverging；Peony, rose have the function of activating microcirculation and removing stasis medicinal, can promote blood circulation, and prevent the generation of cardiovascular and cerebrovascular complication, promote
Into microcirculation；Chinese yam, cortex cinnamomi balance lung kidney yin sun, can also invigorate the spleen and benefit qi, warm kidney at Cordyceps militaris, while adjust regulating the function of middle-JIAO and lower burnt
Effect.Therefore the application composition can be suitably used for the diabetes patient of various constitutions, due to fundamentally having adjusted patient body
Energy non-equilibrium state, therefore excessively high blood glucose and too low blood glucose can be adjusted simultaneously, improve body vis medicatrix naturae, therefore glycosuria
Foot disease etc. is difficult to the wound to heal also can spontaneous recovery.
A kind of health protection tea of bidirectional modulation blood glucose of the composition of the application, it is by the raw material system including following weight proportion
At：10-30 parts of vine tea, 10-30 parts of peony, 10-30 parts of Chinese yam, 1-5 parts of Cordyceps militaris.Preferably, which can be with
Raw material including following weight proportion：10-15 parts of rose, 10-15 parts of cape jasmine, 10-15 parts of chrysanthemum, 10-15 parts of cortex cinnamomi.
It is furthermore preferred that the health protection tea of the bidirectional modulation blood glucose of the application, is made of the raw material of following weight proportion：Rattan
15-25 parts of tea, 15-25 parts of peony, 15-25 parts of Chinese yam, 2-4 parts of Cordyceps militaris, 12-14 parts of rose, 12-14 parts of cape jasmine, chrysanthemum
12-14 parts, 12-14 parts of cortex cinnamomi.Most preferably, which is made of the raw material of following weight proportion：It is 20 parts of vine tea, male
Pellet spends 20 parts, 20 parts of Chinese yam, 3 parts of Cordyceps militaris, 13 parts of rose, and 13 parts of cape jasmine, 13 parts of chrysanthemum, 13 parts of cortex cinnamomi.
The preparation method of the health protection tea of the bidirectional modulation blood glucose of the application, it is characterised in that using conventional method that raw material is straight
It connects crushing, or with the extract obtained after solvent extraction and drying, adds or be not added the pharmaceutically acceptable auxiliary material of food, be prepared into
The regular dosage forms such as tea bag, capsule, granule, tablet, pill.
Due to containing Multiple components in Chinese medicine composition, the absorption of heterogeneity and extraction efficiency be not high, combines to allow
The ingredient of object can be preferably absorbed, and utilized cordyceps mycelium bioconversion present invention also provides a kind of, made to combine species
The content of effective component greatly improves, and therapeutic effect is more preferable, and taking dose is less.The guarantor of this preparation bidirectional modulation blood glucose
The method of strong tea, it is characterised in that include the following steps：
(1) raw material for weighing corresponding parts by weight pulverizes all raw materials other than Cordyceps militaris, smashed
Raw material crosses 300 meshes, these raw materials are proportionally added into the water of 4-8 times of weight of raw material total amount, are sufficiently mixed, bottling, culture medium
121 DEG C of high pressure sterilization 40min after raw material is sufficiently mixed prepare for inoculation；
(2) by after Cordyceps militaris alcohol surface sterilization, strain is obtained according to traditional vaccination method, and be inoculated with and exist into culture solution
Shake culture on shaking table, obtains strain liquid；
(3) strain liquid of inoculation of medium (2) prepared in step (1), carries out sterile on superclean bench
Operation, when inoculation, strictly observe sterile working process；
(4) dark culture is first used, 20 DEG C of cultivation temperature, air humidity control is cultivated 10 days 60%；Then exist
It is cultivated under 1000lux intensity of illumination, daily illumination 12 hours, 20 DEG C of cultivation temperature, air humidity control is reinforced logical 80%
Wind, to 10 days or so, mycelium switched to golden yellow by white for culture, stopped culture；
(5) cultured products and culture medium that (3) culture obtains integrally are subjected to cryogenic vacuum freeze-drying, moisture after freeze-drying
Content is reduced to 2% hereinafter, ultramicro grinding, is sealed.
Beneficial effect
The health protection tea of the application method can reduce excessively high blood glucose and increase too low blood glucose, and it is automatic to restore body
The ability of balance blood sugar, moreover it is possible to treat the wound for being difficult to heal caused by diabetes, such as diabetes.
The health protection tea prepared using the method for the application bioconversion, compared with raw material directly crushes the health protection tea of preparation,
The various compositions contents such as flavones ingredient, terpene, alcohols, glucoside and glucoside metaclass therein significantly improve, such as dihydromyricetin, Mongolian oak
Pi Su, cordycepic acid etc. can reach preferable effect with lesser dose, and effect is substantially better than individual vine tea, also superior to
Raw material directly crushes the health protection tea of preparation.
Every kind of component of the health protection tea all has very high safety, is all the raw material that can be used in health care product, and
It is verified by animal acute toxicity and long term toxicity test, the composition itself is to experimental animal also without overt toxicity.
The health protection tea has the function of preferable hypoglycemic, lowering blood pressure and blood fat, is suitable for having diabetes, height simultaneously
Unstable, the fluctuated patient of the patient of blood lipid or hypertension, especially glycemic control, can with conventional hypoglycemic, drop
In the case that blood pressure, blood lipid-lowering medicine are with using, about started to take effect at 1 month or so.Meanwhile health protection tea of the present invention is in stabilised blood
While sugar, blood pressure, blood lipid, mitigate or treated complication caused by three height, is also applied for sugar tolerance patient and potential sugar
Urinate the daily health caring of disease, hypertension, hyperlipemic patients (fat, genetic background and living habit are irregular).
Wound healing is fast in use and is not susceptible to be complicated by infection for the health protection tea, 3 days or so after generally taking
Wound just no longer expands, and starts within 1 week or so incrustation and closes up, 2 weeks to 1 month scab falls recovery from illness, and no longer recurs.
The speed that Principle of Pain mitigates is fast, and the pain for generally taking afternoon to two days wounds just substantially mitigates.
Specific embodiment
Vine tea, peony, Chinese yam, rose, cape jasmine, chrysanthemum, cortex cinnamomi are purchased from the big pharmacy Nanjing Yi Feng, and Cordyceps militaris is purchased from Weihai
Hill bioengineering Co., Ltd.
Embodiment 1
Vine tea 30g, peony 30g, Chinese yam 30g, Cordyceps militaris 5g, rose 15g, cape jasmine 15g, chrysanthemum 15g, cortex cinnamomi 15g, powder
Broken 20 mesh of mistake is distributed into the tea bag of non-woven fabrics packaging, every packet 5g.
Embodiment 2
Vine tea 20g, peony 20g, Chinese yam 20g, Cordyceps militaris 3g, rose 13g, cape jasmine 13g, chrysanthemum 13g, cortex cinnamomi 13g, powder
Broken 20 mesh of mistake is distributed into the tea bag of non-woven fabrics packaging, every packet 5g.
Embodiment 3
Vine tea 10g, peony 10g, Chinese yam 10g, Cordyceps militaris 1g, rose 10g, cape jasmine 10g, chrysanthemum 10g, cortex cinnamomi 10g, powder
Broken 20 mesh of mistake is distributed into the tea bag of non-woven fabrics packaging, every packet 5g.
Embodiment 4
Vine tea 100g, peony 100g, Chinese yam 100g, Cordyceps militaris 10g, rose 100g, cape jasmine 100g, chrysanthemum 100g, meat
Osmanthus 100g, is extracted with water, and extracts medicinal extract, dry, pulverize, and customary adjuvant is added, capsule is made.
Embodiment 5
(1) by vine tea 200g, peony 200g, Chinese yam 200g, rose 130g, cape jasmine 130g, chrysanthemum 130g, cortex cinnamomi 130g
It is pulverized, smashed raw material crosses 300 meshes, these raw materials are proportionally added into the water of 6 times of weight of raw material total amount, are filled
Divide mixing, bottling, 121 DEG C of high pressure sterilization 40min after culture medium raw material is sufficiently mixed prepare for inoculation.
(2) selection 30g fruiting bodies of cordyceps militaris obtains after Cordyceps militaris alcohol surface sterilization according to traditional vaccination method
Strain, and it is inoculated with culture solution shake culture on shaking table, obtain strain liquid；
(3) strain liquid of inoculation of medium (2) prepared in step (1), carries out sterile on superclean bench
Operation, when inoculation, strictly observe sterile working process；
(4) dark culture is first used, 20 DEG C of cultivation temperature, air humidity control is cultivated 10 days 60%；Then exist
It is cultivated under 1000lux intensity of illumination, daily illumination 12 hours, 20 DEG C of cultivation temperature, air humidity control is reinforced logical 80%
Wind, to 10 days or so, mycelium switched to golden yellow by white for culture, stopped culture；
(5) cultured products and culture medium that (3) culture obtains integrally are subjected to cryogenic vacuum freeze-drying, moisture after freeze-drying
Content is reduced to 2% hereinafter, pulverizing, loading non-woven fabrics tea bag, and a packet 5g is sealed.
Pharmacological experiment and clinic trial data
1 toxicological experiment of experimental example
Embodiment 1,5 distinguishes daily 2500mg/kg to intragastric administration on mice, and embodiment 4 is distinguished daily 500mg/kg and filled to mouse
Stomach is observed one week, has no that obvious poisoning symptom also without death, illustrates pharmaceutical composition of the invention acute toxicity for oral administration very
It is small.
Embodiment 1,5 gives rat oral gavage, daily 1000,2000mg/kg respectively；Embodiment 4 distinguish daily 500mg/kg to
Intragastric administration on mice, successive administration 30 and 90d, the rat diet, weight, blood urine routine, hepatic and renal function after long term administration are without obvious
Change, to the pathologic examination of 18 important organs such as the heart of experimental animal, brain, liver, kidney and tissue also without overt toxicity.
4 people of normal person voluntarily takes the health protection tea 5g or 10g of embodiment 1,4,5 daily, and after a week, front and back is taken in comparison,
On an empty stomach, postprandial blood sugar, blood lipid, blood pressure is without significant changes, and blood routine, routine urinalysis are without significant changes.Only when human body daily
When embodiment 5 reaches 10g, there is the appearance of mild diarrhea situation.
2 zoopery of experimental example
In order to study the application health protection tea to the dual regulation of blood glucose, we have detected the hungry blood of mouse respectively
Sugar, random blood glucose level, glucose tolerance and hypoglycemia recovery capacity.
42 healthy male C 57 BL/6 J mouses are placed in standard laboratory atmosphere and are raised, are adapted to after a week, random point
For blank control group (CTL), melbine aqueous solution group (Metformin), Cordyceps militaris group (Cordyceps group) and embodiment 1
(Tea1), embodiment 2 (Tea2), embodiment 3 (Tea3), seven groups of embodiment 5 (Tea5), every group each 6.Seven groups of every natural gift of mouse
Single aqueous solution (900mg/ for steaming water, melbine aqueous solution (128mg/kg) and Cordyceps militaris, embodiment 1,2,3,5 is not drunk
Kg) continue one month.
2.1 starvation/random blood glucose level detection
Mouse elder generation overnight fasting about 16h, during which free water, then take blood to be detected with blood glucose meter by tail end
Numerical value is the hungry blood glucose value of mouse.The detection of random blood sugar was carried out in the i.e. dark period in feed period of mouse, during which small
Mouse freely ingests, free water, from mouse tail end extracting vein blood, is with the blood sugar test test paper reading numerical values in blood glucose meter
For random blood sugar.Every cage mouse fills feed after experiment.
2.2 glucose tolerance tests (GTT)
After mouse overnight fasting, the empty stomach basal plasma glucose of every mouse is measured, measured value thinks the blood glucose value of 0min, then
By the way that D-Glucose timing since finishing injection of 1g/kg is injected intraperitoneally, tail successively is taken in 15,30,60,120min
Blood measures the blood glucose value of every mouse various time points with blood glucose meter.Feed is filled after the test.
2.3 hypoglycemia increase experiment
After mouse overnight fasting, the empty stomach basal plasma glucose of every mouse is measured, measured value thinks the blood glucose value of 0min, then
Detect seven groups of mouse 60 for drinking different tea and the blood glucose value after 120min.
The results show that seven groups of mouse are all not significantly different (p on hungry and random blood sugar>0.05)；GTT experimental result
Display is injected intraperitoneally after glucose solution, and seven groups of mouse blood sugar concentration gradually rise when 15,30min and reach in 30min
Highest point, Tea group have significant difference (P compared with CTL group<0.01), seven groups of blood glucose values have declined after 60min, with CTL group
Or Met group is compared, the numerical value of Cordyceps group decline between CTL group and Met group, Tea1,2,3,5 groups of decline it is more,
They compare between difference have conspicuousness distinguish (P<0.01)；CTL group blood glucose does not drop to normal level also when 120min, and
A group mouse drops to normal level for Tea1,2,3,5, illustrates to take mouse glucose-tolerant with higher after the application health protection tea
Power, i.e., the described health protection tea not only has the function of reducing high blood glucose concentration, and is better than the same dose of Cordyceps militaris, and entire
The change of blood sugar of health protection tea is more stable in the process.
Mouse starvation 16h simulates hypoglycaem ic condition, at this time seven groups of mouse drink respectively it is single steam water, melbine aqueous solution with
And the aqueous solution of Cordyceps militaris and Tea1,2,3,5, when 60min the blood glucose value of seven groups of mouse still decline and the decline of CTL group most
It is more, and in 120min detection, the blood glucose value of 1,2,3,5 group of mouse of Tea has built up and is gradually restored to base level, and
CTL group and Met group, Cordyceps group blood glucose value do not increase and are but constantly in downward trend, CTL group and Tea Tea1,2,3,5
Group comparing difference has conspicuousness (P<0.01), illustrate that the application health protection tea to hypoglycemia caused by starvation, has significant blood glucose increasing
Effect, and individually Cordyceps militaris is without this effect.
And by discovery, reduce the rapid degree Tea5 group of high blood glucose concentration>Tea2 group>Tea1 group>Tea3 group rises blood
The rapid degree Tea5 group of sugar>Tea2 group>Tea3 group>Tea1 group, it can be seen that, the effect of Tea5 group is better than other proportions and system
The present composition that Preparation Method obtains, the proportion of Tea2 group are better than of the present invention group that other proportions prepared by same method obtain
Close object.
3 clinic trial overview of the data of experimental example
It chooses 14 and suffers from the diabetic of diabetes, wherein having 3 people's Complicated with Hypertension, wherein there is 2 to be easy
Existing transient hypoglycemia；There are also the difference of 3 people's postprandial blood sugars and fasting blood-glucose is very big.Wherein there is the both concurrent high blood of 1 patient
Pressure, while blood glucose fluctuation is also unstable.The diseases such as diabetes, diabetes, the hypertension of patient are that hospital makes a definite diagnosis, and are sugar
Urine foot disease is difficult to heal or blood glucose fluctuation is excessive and invalid using conventional medicine, voluntarily takes orally pharmaceutical composition of the present invention.
Treatment method：First group and second group, every group of 7 people, the tea of first group of oral embodiment 2, second group of oral implementation
The tea of example 5 is wrapped, is continuously taken one month for one day 2.Patient original treatment diabetes taken or hypertension drug during the experiment
Still constant, but without using any other dermatology is for oral administration or external drug.When grouping, concurrent high blood is assigned in first group
2 big people of 1 people of patient of pressure, 1 people of patient of concurrent hypoglycemia, change of blood sugar difference are assigned with Complicated with Hypertension in second group
2 people of patient, big 1 people of 1 people of patient of concurrent hypoglycemia, change of blood sugar difference；Other patients are randomly assigned.
The criterion of therapeutical effect of diabetes：Recovery from illness：Clinic skin disease damage completely disappears；It is effective：Clinic skin disease damage reduces, and disappears
Area is lost to completely disappear 2/3 or more, but not；Effectively：Clinic skin disease damage reduces, and disappearance area does not have 1/3 or more
It completely disappears；In vain：The performance of clinic skin disease damage is constant or aggravates.
The excessive criterion of therapeutical effect of blood glucose fluctuation：Effectively：Change of blood sugar is stablized, no longer occur hypoglycemia or fasting blood-glucose with
The difference ratio of postprandial blood sugar is significantly reduced before taking.In vain：Difference between hypoglycemia or fasting blood-glucose and postprandial blood sugar
Do not improve.
Experimental result：The treatment condition of first group of diabetes：Recovery from illness 2, effective 3, effective 2.Second group
The treatment condition of diabetes：Recovery from illness 5, effective 2, effective 0.It can be seen that the tea of embodiment 2 and the tea of embodiment 5 are to sugar
Urinating foot disease has apparent therapeutic effect, and wherein the therapeutic effect of the tea of embodiment 5 is more preferably.
2 had the diabetic of transient Hypoglycemic symptoms all to indicate originally, and taking conventional antidiabetic drug originally can not control
There is not the case where transient hypoglycemia after taking drug of the present invention again in glucostasis processed.Other 3 postprandial blood sugars with
Mean difference between fasting blood-glucose is all declined, and is fallen below between 6mmol/l-10mmol/l respectively, due to blood glucose water
Flat decline simultaneously becomes steady, after the hypoglycemic agent decrement that place was taken used originally, still can maintain more stable blood glucose water
It is flat.There are 2 reflections to take depressor originally in the patient with diabetic feet of 3 Complicated with Hypertension, after taking drug of the present invention, blood pressure
Decline, depressor are also reduced.
Typical case：
(1) male, 67 years old, diabetes 22 years, Complicated with Hypertension.
Before the tea for taking the embodiment of the present invention 2, diabetes 3 years, ulcer was difficult to heal foot wounds repeatedly, after medication,
Beginning wound pain mitigates within 2nd day, and wound starts to form a scab within less than 2 weeks, heals successively after 1-1.5 months, continues to hurt for medication 1 month
Mouth does not recur.Unstable blood pressure is fixed before taking medicine, and blood pressure high pressure is also always in 160mmHg or more, fatiguability, after medication 1 month, blood
Pressing off the beginning stablizes and drops to 140mmHg hereinafter, depressor is reduced, and feels not easy to fatigue.
(2) male, 64 years old, diabetes 8 years.
Before the tea for taking the embodiment of the present invention 2, leg has do not heal for ulcer 2 months, and has diabetic peripheral neuritis disease
Shape, wound and numbness in hands and feet pain.The pain that the 3rd day starts wound and trick of taking medicine starts to be mitigated, after 1 month, ulcer
Healing completely, brothers' no longer numb pain.
(3) female, 61 years old, diabetes 20 years.
Before taking pharmaceutical composition of the present invention, blood glucose fluctuation is larger, unstable, postprandial blood sugar 11mmol/l or more, on an empty stomach
It is easy dizziness again, blood glucose is only 3.5mmol/l when minimum, and the ice-cold numbness of legs and feet, after medication 1.5 months, legs and feet are warm consciousness,
Blood glucose fluctuation is more steady, and postprandial blood sugar drops to 8.6mmol/l, no longer dizzy on an empty stomach.At the tea for taking the embodiment of the present invention 51
After month, after antidiabetic drug decrement before, remain to maintain lower blood glucose level.
(4) female, 61 years old, diabetes 5 years,
Take antidiabetic drug gliclazide, Acarbose, melbine, depressor Valsartan, nifedipine, blood glucose blood pressure for a long time
Unstable, blood glucose difference (amplitude of variation) is especially big, fluctuates between 10mmol/l to 30mmol/l, firmly 3 hospitals.It takes
The medicine is to after 1 month, and blood glucose blood pressure stabilization, preprandial glucose is generally in 7-8mmol/l, postprandial 10mmol/l or less.At present
It takes the tea of the embodiment of the present invention 52 months, also is continuing to take.
Although a specific embodiment of the invention has been described in detail, those skilled in the art is according to having disclosed
All introductions, those details can be carry out various modifications and be replaced, these changes are within the scope of the invention.This
Whole protection scopes of invention include all authority requirement and its equivalent technical solution.
Claims (8)
1. a kind of health protection tea of bidirectional modulation blood glucose, it is characterised in that：It is including made of the raw material of following weight proportion：
10-30 parts of vine tea, 10-30 parts of peony, 10-30 parts of Chinese yam, 1-5 parts of Cordyceps militaris.
2. the health protection tea of bidirectional modulation blood glucose as described in claim 1, it is characterised in that：It further includes following weight proportion
Raw material：10-15 parts of rose, 10-15 parts of cape jasmine, 10-15 parts of chrysanthemum, 10-15 parts of cortex cinnamomi.
3. the health protection tea of bidirectional modulation blood glucose as claimed in claim 2, it is characterised in that：It is by the original of following weight proportion
Made of material：15-25 parts of vine tea, 15-25 parts of peony, 15-25 parts of Chinese yam, 2-4 parts of Cordyceps militaris, 12-14 parts of rose, cape jasmine
12-14 parts, 12-14 parts of chrysanthemum, 12-14 parts of cortex cinnamomi.
4. the health protection tea of bidirectional modulation blood glucose as claimed in claim 3, it is characterised in that：It is by the original of following weight proportion
Made of material：20 parts of vine tea, 20 parts of peony, 20 parts of Chinese yam, 3 parts of Cordyceps militaris, 13 parts of rose, 13 parts of cape jasmine, 13 parts of chrysanthemum, meat
13 parts of osmanthus.
5. the preparation method of the health protection tea of bidirectional modulation blood glucose described in claim 1-4, it is characterised in that use conventional method
Raw material is directly crushed, or with the extract obtained after solvent extraction and drying, add or food is not added and is pharmaceutically acceptable auxiliary
Material, is prepared into the regular dosage forms such as tea bag, capsule, granule, tablet, pill.
6. the preparation method of the health protection tea of bidirectional modulation blood glucose described in claim 1-4, it is characterised in that include the following steps：
(1) raw material for weighing corresponding parts by weight pulverizes all raw materials other than Cordyceps militaris, smashed raw material
300 meshes are crossed, these raw materials are proportionally added into the water of 4-8 times of weight of raw material total amount, are sufficiently mixed, are bottled, culture medium raw material
121 DEG C of high pressure sterilization 40min after being sufficiently mixed prepare for inoculation；
(2) by after Cordyceps militaris alcohol surface sterilization, strain is obtained according to traditional vaccination method, and be inoculated with into culture solution in shaking table
Upper shake culture, obtains strain liquid；
(3) strain liquid of inoculation of medium (2) prepared in step (1), carries out sterile working on superclean bench,
Sterile working process is strictly observed when inoculation；
(4) dark culture is first used, 20 DEG C of cultivation temperature, air humidity control is cultivated 10 days 60%；Then in 1000lux light
According to cultivating under intensity, daily illumination 12 hours, 20 DEG C of cultivation temperature, air humidity control reinforces ventilation, culture to 10 80%
It or so, mycelium switch to golden yellow by white, stop culture；
(5) cultured products and culture medium that (3) culture obtains integrally are subjected to cryogenic vacuum freeze-drying, moisture content after freeze-drying
2% is reduced to hereinafter, ultramicro grinding, is sealed.
7. the health protection tea of method of claim 6 preparation is on the health care product, food or drug of preparation bidirectional modulation blood glucose
Application, it is characterised in that the health protection tea can reduce excessively high blood glucose and increase too low blood glucose, restore body and put down automatically
The ability of weighing apparatus blood glucose.
8. the health protection tea of method of claim 6 preparation is on the health care product, food or drug of preparation bidirectional modulation blood glucose
Application, it is characterised in that the health protection tea can also treat the wound for being difficult to heal caused by diabetes, such as diabetes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810770154.7A CN108904671B (en) | 2018-07-13 | Health tea capable of regulating blood sugar bidirectionally and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810770154.7A CN108904671B (en) | 2018-07-13 | Health tea capable of regulating blood sugar bidirectionally and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN108904671A true CN108904671A (en) | 2018-11-30 |
| CN108904671B CN108904671B (en) | 2024-06-11 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233032A (en) * | 2015-10-20 | 2016-01-13 | 李竹岩 | Traditional Chinese medicine for treating diabetes |
| CN105996022A (en) * | 2016-07-12 | 2016-10-12 | 江苏大学 | Method for producing functional foods by simultaneously converting Chinese yam from cordyceps taishanensis |
| CN106900961A (en) * | 2016-12-31 | 2017-06-30 | 安徽明珍堂养生品有限公司 | A kind of rose brown sugar block health food |
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233032A (en) * | 2015-10-20 | 2016-01-13 | 李竹岩 | Traditional Chinese medicine for treating diabetes |
| CN105996022A (en) * | 2016-07-12 | 2016-10-12 | 江苏大学 | Method for producing functional foods by simultaneously converting Chinese yam from cordyceps taishanensis |
| CN106900961A (en) * | 2016-12-31 | 2017-06-30 | 安徽明珍堂养生品有限公司 | A kind of rose brown sugar block health food |
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