CN108888659A

CN108888659A - Chinese medicine composition, the pill and preparation method thereof for treating caput femoris necrosis syndrome of blood stasis and stagnant qi

Info

Publication number: CN108888659A
Application number: CN201810973563.7A
Authority: CN
Inventors: 曹玉举; 张大鹏; 郭永昌; 张鑫杰; 陈喜凤; 王俊发
Original assignee: ZHENGZHOU TRADITIONAL CHINESE HOSPITAL OF ORTHOPAWDICS
Current assignee: ZHENGZHOU TRADITIONAL CHINESE HOSPITAL OF ORTHOPAWDICS
Priority date: 2018-08-24
Filing date: 2018-08-24
Publication date: 2018-11-27
Anticipated expiration: 2038-08-24
Also published as: CN108888659B

Abstract

The invention discloses a kind of Chinese medicine composition for treating caput femoris necrosis syndrome of blood stasis and stagnant qi, pill and preparation method thereof, which includes the raw material of following parts by weight：37~53 parts of puncture multitude of 197~229 parts of rhizoma corydalis, 127~155 parts of fennel seeds, 64~82 parts of Artemisia anomala, 86~104 parts of Radix Paeoniae Alba, 84~102 parts of Herba Lycopi, 86~104 parts of radix paeoniae rubra, 84~102 parts of Radix Angelicae Sinensis, 64~82 parts of the rhizome of davallia, 64~82 parts of Herba Epimedii and thorn.Chinese medicine composition of the invention is using rhizoma corydalis and fennel seeds as monarch drug in a prescription, with Artemisia anomala, Radix Paeoniae Alba, radix paeoniae rubra, Herba Lycopi, when being classified as ministerial drug, using the rhizome of davallia and Herba Epimedii as adjutant, it is to make medicine with tribulus terrestris, not only had effects that blood circulation and removing stasis, promoting qi circulation and relieving pain and soothing liver-qi stagnation, but also the continuous folding that has effects that cure the wound, strengthened muscles and bones and invigorating QI and blood, tonification and purgation in combination, giving consideration to both the incidental and fundamental, it is significant in efficacy for caput femoris necrosis syndrome of blood stasis and stagnant qi.

Description

The Chinese medicine composition, pill and its preparation for treating caput femoris necrosis syndrome of blood stasis and stagnant qi Method

Technical field

The present invention relates to Chinese medicine compound prescription technical fields, treat caput femoris necrosis syndrome of blood stasis and stagnant qi in particular to a kind of Chinese medicine composition, pill and preparation method thereof.

Background technique

Caput femoris necrosis is femoral head venous stasis, arterial blood for impaired or interrupting keeps osteocyte and marrow components part dead Subsequent reparation is died and occurred, bone necrosis are then caused, causes femur header structure to change and collapse, causes hip arthralgia And the disease of dysfunction.Caput femoris necrosis can be divided into traumatic necrosis of bone and atraumatic osteonecrosis, and traumatic necrosis of bone is Refer to Hip Fracture caused by a variety of causes, the main inducing of atraumatic restorative technique is to drink and largely use hormone.Such as Malpractice, it is collapse of femoral head that 80% or so patient can develop in 1~4 year, and then developing is that serious hipbone is arthritic Stage, it has to take hip replacement.Caput femoris necrosis is apt to occur in 20~50 years old person between twenty and fifty, average age 36 years old, gives and suffers from Person's life brings inconvenience, seriously endangers between twenty and fifty health.

Currently, the means for the treatment of caput femoris necrosis include operative treatment and traditional Chinese medicine treatment, operative treatment includes that marrow core subtracts Pressure art, vessel bundle implantation art, bone grafting operation, osteotomy, arthroplasty of hip, the treatment of porous tantalum stick, mesenchymal stem cell are controlled Treat etc..But operative treatment is very big to human injury, and curative effect cannot also be affirmed；And operative treatment is there are certain risk, and postoperative It is easy recurrence.

Guarantor's hip therapy based on traditional Chinese medicine treatment achieves centainly in the treatment of early metaphase atraumatic restorative technique Effect, protecting hip treatment by traditional Chinese medicine can make patient obtain the hip joint relatively painless, function is normal, to delay or keep away Exempt to carry out prosthetic replacement.Traditional Chinese medicine, which treats caput femoris necrosis, has that hurtless measure, no pain, few side effects, method are simple, lose The advantages that not influencing prosthetic replacement after losing is that the treatment method for being easiest to be accepted by patients and application are most general in China Time method.Modern medicine study has proven to the Important cause of disease that intravascular coagulation is caput femoris necrosis morbidity, in osteonecrosis patient Blood coagulation or fibrinolytic at least exception person's accounting 82.2%.Ossis is gone in the Histopathology studies have shown that necrosis of osteonecrosis Hematopoietic cell is reduced, necrosis denaturation, it is seen that is dispersed in calcification, fibrous connective tissue regeneration.

Existing Chinese medicine study is divided into syndrome of blood stasis and nephrasthenia syndrome to the differentiation of symptoms and signs for classification of syndrome of caput femoris necrosis more, also has and dialectical is Phlegm-blood stasis card and qi-blood deficiency person, but the research of syndrome of blood stasis and stagnant qi report is not much.According to traditional Chinese medical theory, gas be blood it General, blood being the material foundation of QI, qi and blood influence each other, and not only the stagnation of the circulation of vital energy can cause blood stasis, and blood stasis also can lead to the stagnation of the circulation of vital energy, clinically for blood stasis gas It is stagnant to set about coping with simultaneously.The tcm causa morbi and pathogenesis of caput femoris necrosis syndrome of blood stasis and stagnant qi can be summarized as follows：After wound Bone breaks the injury of tendon and muscle, stagnation of QI and blood；Or emotion-thought abnormal, such as raged impairing liver, anxiety impairs the spleen the obstruction of the circulation of vital energy and cause blood stasis；Or being invaded by exogenous pathogen,invasion of exogenous pathogen, retardance warp Arteries and veins and cause stagnation of QI and blood；Or diet is not normal, medication mistake degree and cause stagnation of QI and blood, QI-blood circulation is unsmooth, venation block, bone mistake moistens It supports.And syndrome of blood stasis and stagnant qi is more common in Traumatic Avascular Necrosis of Femoral Head and avascular necrosis of femoral head early metaphase. The disconnected injury of tendon and muscle of bone after wound, hemostasis retention；Feelings will is unsuccessful usually, people of stagnation of liver qi, melancholy,anxiety and spleen, most easily leads to blood stasis；Impression Exopathogen obstruction of meridian can also cause blood stasis；Diet medication is not normal, damages qi and blood, obstruction of meridian；The people for being known as blood stasis is easy resistance again The operation of stagnant gas forms stagnation of QI and blood.Stagnation of QI and blood, blockage of main and collateral channels, therefore see limping, movable unfavorable, hip shouting pain, distending pain, when Weight when light；Hemostasis is stagnated visible local pain and is not moved, and hypnalgia is very；Mental depression, edgy, distending pain in the chest and hypochondrium, sighing frequently are all For the stagnation of the circulation of vital energy as；Tongue is purple dim or has petechia, and tongue fur is thin white, stringy and hesitant pulse be stagnation of QI and blood as.

The clinical manifestation of caput femoris necrosis syndrome of blood stasis and stagnant qi is：It walks lamely, lower limb exercise is unfavorable, hip pain, groin pain Bitterly, weight, distending pain or shouting pain when light when, or with mental depression, edgy, distending pain in the chest and hypochondrium, sighing frequently, tongue is purple dim or has the stasis of blood Point, tongue fur is thin white, stringy and hesitant pulse.

Have been observed that a large amount of syndrome of blood stasis and stagnant qi Patients with Aseptic Necrosis of Femoral, syndrome of blood stasis and stagnant qi femoral head are bad in our clinics Extremely great pain is brought also to cause heavy burden to society to patient.

Summary of the invention

In view of this, a kind of Chinese medicine composition for treating caput femoris necrosis syndrome of blood stasis and stagnant qi provided by the invention, pill and Preparation method preferably overcomes the above-mentioned problems of the prior art and defect, the treatment caput femoris necrosis stagnation of QI and blood The Chinese medicine composition of card selects natural Chinese traditional medicines raw material, using rhizoma corydalis and fennel seeds as monarch drug in a prescription, with Artemisia anomala, Radix Paeoniae Alba, radix paeoniae rubra, Herba Lycopi, when being classified as ministerial drug, using the rhizome of davallia and Herba Epimedii as adjutant, be to make medicine with tribulus terrestris, comprehensively utilize above-mentioned each Chinese medicine former material The Action advantage of material and mutually synergistic effect had not only had effects that blood circulation and removing stasis, promoting qi circulation and relieving pain and soothing liver-qi stagnation, but also have had and cure the wound Continuous folding strengthens muscles and bones and the effect of invigorating QI and blood, tonification and purgation in combination, giving consideration to both the incidental and fundamental is both directed to the entirety of femoral head syndrome of blood stasis and stagnant qi Performance, and guided drugs to illness station with Liver Channel drug and tying-in drug, the part of caput femoris necrosis is looked after, for caput femoris necrosis blood stasis Syndrome of qi stagnation is significant in efficacy, easy to use.

A kind of Chinese medicine composition for treating caput femoris necrosis syndrome of blood stasis and stagnant qi, the raw material comprising following parts by weight：Prolong recklessly 197~229 parts of rope, 127~155 parts of fennel seeds, 64~82 parts of Artemisia anomala, 86~104 parts of Radix Paeoniae Alba, 84~102 parts of Herba Lycopi, radix paeoniae rubra 37~53 parts of puncture multitude of 86~104 parts, 84~102 parts of Radix Angelicae Sinensis, 64~82 parts of the rhizome of davallia, 64~82 parts of Herba Epimedii and thorn.

Further, the rhizoma corydalis is 201~225 parts；The fennel seeds are 131~151 parts.

Further, the Artemisia anomala is 68~78 parts；The Radix Paeoniae Alba is 90~100 parts；The Herba Lycopi is 88~98 parts； The radix paeoniae rubra is 90~100 parts；It is described to be classified as 88~98 parts.

Further, the rhizome of davallia is 68~78 parts；The Herba Epimedii is 68~78 parts；The tribulus terrestris is 41~49 Part.

Further, the rhizoma corydalis is 213 parts；The fennel seeds are 141 parts；The Artemisia anomala is 73 parts；It is described white Chinese herbaceous peony is 95 parts；The Herba Lycopi is 93 parts；The radix paeoniae rubra is 95 parts；It is described to be classified as 93 parts；The rhizome of davallia is 73 parts；It is described excessive The sheep leaves of pulse plants is 73 parts；The tribulus terrestris is 45 parts.

The present invention also provides a kind of pill for treating caput femoris necrosis syndrome of blood stasis and stagnant qi, the pill includes above-mentioned controls Treat the Chinese medicine composition of caput femoris necrosis syndrome of blood stasis and stagnant qi.

Further, 2.5~3.5 parts of starch have been additionally added in every 100 parts of Chinese medicine compositions.

The present invention also provides a kind of preparation methods of pill for treating caput femoris necrosis syndrome of blood stasis and stagnant qi：The pill packet Include the Chinese medicine composition of above-mentioned treatment caput femoris necrosis syndrome of blood stasis and stagnant qi；The preparation method includes：The raw material is crushed After be uniformly mixed so as to obtain powder.

The preparation method further includes：100 parts of powders, 2.5~3.5 parts of starch and 28~42 parts of pure water are mixed Wet ball is made after stirring.

The present invention also provides by the wet ball it is dry to moisture 5wt% or less to obtain vegetable pill, and the vegetable pill is used Active charcoal bag charcoal clothing and with talcum powder polishing, wherein every 100 parts of vegetable pills use 0.45~0.55 part of active carbon and 0.45 ~0.55 part of talcum powder.

Compared with prior art, a kind of Chinese medicine composition for treating caput femoris necrosis syndrome of blood stasis and stagnant qi of the invention, pill And preparation method thereof beneficial effect be：

The Chinese medicine composition for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi of the invention selects natural Chinese traditional medicines raw material, to prolong Hu Suo and fennel seeds are monarch drug in a prescription, with Artemisia anomala, Radix Paeoniae Alba, radix paeoniae rubra, Herba Lycopi, when being classified as ministerial drug, using the rhizome of davallia and Herba Epimedii as adjutant, Be to make medicine with tribulus terrestris, comprehensively utilize the Action advantage and mutual synergistic effect of above-mentioned each Chinese herb, both had promoting blood circulation by The effect of stasis of blood, promoting qi circulation and relieving pain and soothing liver-qi stagnation, and the continuous folding that has effects that cure the wound, strengthen muscles and bones and invigorating QI and blood, tonification and purgation in combination, Giving consideration to both the incidental and fundamental, is not only directed to the overall performance of femoral head syndrome of blood stasis and stagnant qi, but also is guided drugs to illness station with Liver Channel drug and tying-in drug, looks after It is significant in efficacy for caput femoris necrosis syndrome of blood stasis and stagnant qi to the part of caput femoris necrosis, it is easy to use.In addition, of the invention controls The preparation method for treating the pill of caput femoris necrosis syndrome of blood stasis and stagnant qi is simple, and preparation cost is low, and use is safe, no pain, nontoxic pair Effect.

To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment is cited below particularly, makees detailed It is described as follows.

Specific embodiment

To facilitate the understanding of the present invention, it elaborates below with reference to the mode of embodiment to technical solution of the present invention, In the following description, numerous specific details are set forth in order to facilitate a full understanding of the present invention.

But the invention can be embodied in many other ways as described herein, those skilled in the art can be with Similar improvement is done without violating the connotation of the present invention, therefore the present invention is not limited to the specific embodiments disclosed below.

A kind of Chinese medicine composition for treating caput femoris necrosis syndrome of blood stasis and stagnant qi, the raw material comprising following parts by weight：

Rhizoma corydalis 197~229 parts such as 197 parts, 199 parts, 201 parts, 205 parts, 209 parts, 213 parts, 215 parts, 219 parts, 221 Part, 225 parts, 227 parts or 229 parts etc.；

Such as 127 parts of 127~155 parts of parts of fennel seeds, 129 parts, 131 parts, 135 parts, 139 parts, 141 parts, 143 parts, 145 parts, 148 parts, 151 parts, 153 parts or 155 parts etc.；

Such as 64 parts, 66 parts, 68 parts, 70 parts, 73 parts, 75 parts, 78 parts, 80 parts or 82 parts of 64~82 parts of Artemisia anomala；

Such as 86 parts, 88 parts, 90 parts, 92 parts, 95 parts, 98 parts, 100 parts, 102 parts or 104 parts of 86~104 parts of Radix Paeoniae Alba；

Such as 84 parts, 86 parts, 88 parts, 90 parts, 93 parts, 95 parts, 98 parts, 100 parts or 102 parts of 84~102 parts of Herba Lycopi；

Such as 86 parts, 88 parts, 90 parts, 92 parts, 95 parts, 98 parts, 100 parts, 102 parts or 104 parts of 86~104 parts of radix paeoniae rubra；

Such as 84 parts, 86 parts, 88 parts, 90 parts, 93 parts, 95 parts, 98 parts, 100 parts or 102 parts of 84~102 parts of Radix Angelicae Sinensis；

Such as 64 parts, 66 parts, 68 parts, 70 parts, 73 parts, 75 parts, 78 parts, 80 parts or 82 parts of 64~82 parts of the rhizome of davallia；

Such as 64 parts, 66 parts, 68 parts, 70 parts, 73 parts, 75 parts, 78 parts, 80 parts or 82 parts of 64~82 parts of Herba Epimedii；

Such as 37 parts, 39 parts, 41 parts, 43 parts, 45 parts, 47 parts, 49 parts, 51 parts or 53 parts of 37~53 parts of puncture multitude of thorn.

It should be noted that rhizoma corydalis, is the dry tuber of papaveraceae plant corydalis；Its acrid flavour, hardship, temperature；Return liver, spleen Through.Rhizoma corydalis has effects that promoting blood circulation, promoting the circulation of qi and analgesic, has good effect for various pains, is suitable for arthralgia and myalgia especially, enters liver Also there is good effect for hernia pain.Pharmaceutical research proves that rhizoma corydalis has good analgesic activity, and analgesic mechanism is in Pivot nervous system is related, and analgesic activity is weak compared with morphine, but without additive；It also has sedation, has to femoral artery certain Dilating effect, expansion blood vessel effect may be release pain effect the reason of one of.In addition, rhizoma corydalis also has to flesh The relexation of meat.

Fennel seeds are the dry mature fruit of umbelliferae fennel；Its taste is acrid in flavour and warm in nature；Return liver,kidney,spleen, stomach meridian.Fennel fruit Perfume has effects that eliminating cold to stop pain and regulating qi-flowing for harmonizing stomach；It is mainly used for cold hernia stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, abdomen crymodynia, stomach duct and abdomen are swollen Bitterly.It enters Liver Channel, and can warm up kidney eliminating cold to stop pain, is suitable for hernia pain especially.

Artemisia anomala is the wounded in the battle herb of compositae plant artemisia anomalas；It is its acrid flavour, slight bitter, warm-natured；Return heart, liver, the spleen channel.Artemisia anomala Have effects that broken stasis of blood promoting menstruation, hemostasia and detumescence；It is mainly used for stasis of blood, lumps in the chest and abdomen, traumatic injury, metal-inflicted wound bleeding, rheumatism Numbness pain, ulcerative carbuncle pyogenic infections and dyspeptic abdominalgia etc..《Book on Chinese herbal medicine is looked for the truth》：Artemisia anomala, bitter tepor, multipotency broken stasis of blood promoting menstruation, except swollen under disease, and Only metal-inflicted wound blood goes out, size hematochezia, burn poison.Edge blood in the person, this expensive logical work is stagnant and not all right, then blood benefit it is stagnant without go out, and Abdominal mass turgor is more；Capable and more than, then blood is also stagnant without receiving, and blood is made to go out benefit very, posts slave always and be the product of blood-breaking, therefore can just stagnant person It is broken and i.e. logical, and logical person is broken and receives.Pharmaceutical research shows that it has effects that release smooth muscle spasm.

Radix Paeoniae Alba is the dry root of cohosh Chinese herbaceous peony；Its bitter, acid, it is slightly cold；Return liver, the spleen channel.Radix Paeoniae Alba has blood-nourishing tune The effect of through, astringing YIN to stop sweating, the analgesic of soft liver and suppressing liver-YANG；It is primarily useful for treatment blood deficiency chlorosis, hypochondriac pain, abdominal pain, four limbs contraction Pain and headache and dizziness etc..Pharmaceutical research show Radix Paeoniae Alba have apparent analgesic activity, sedation, smooth muscle spasmolysis effect, Blood vessel is expanded, effect, platelet aggregation-against and the improvement anaemia effect of organic blood flow volume are increased.

Herba Lycopi is the dry aerial parts of Lamiaceae plant hair leaf lycopus lucidus；Its bitter, pungent, tepor；Return liver, the spleen channel. Herba Lycopi has effects that promoting blood circulation for regulating menstruation, easing joint movement tendon and vessel, dissolving stasis disappear carbuncle and inducing diuresis for removing edema.It is primarily useful for abdominal pain due to blood stasis, muscle Bone wound, sore and toxic and oedema ascites etc..Pharmaceutical research shows that Herba Lycopi has the effects that improve circulation and reduces blood viscosity.

Radix paeoniae rubra is the dry root of ranunculaceae plant Chinese herbaceous peony or river radix paeoniae rubra；Its bitter, it is slightly cold；Return liver warp.Radix paeoniae rubra has heat-clearing The effect of cool blood and removing blood stasis and acesodyne；It is primarily useful for into ying blood, febrile virulent maculae, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, Disorder Lump in the abdomen accumulation, injury from falling down and carbuncle swells sore etc..Pharmaceutical research shows that radix paeoniae rubra has antithrombus formation, platelet aggregation-against, drop The effects of blood lipid and anti arteriosclerosis.

Radix Angelicae Sinensis is the dry root of umbelliferae angelica；Its taste sweet, acrid, warm；Return liver, the heart, the spleen channel.Chinese angelica blood supplementing promoting blood circulation, Menstruction regulating and pain relieving and relieving rigidity of muscles and joints control muscular constricture and other effects；Be primarily useful for blood deficiency chlorosis, dizziness palpitaition, asthenia cold abdominalgia, rheumatic arthralgia, Injury from falling down, ulcer sores etc..Prepared RADIX ANGELICAE SINENSIS with yellow rice wine has effects that blood circulation.Pharmaceutical research proves that Radix Angelicae Sinensis has reducing blood lipid, resists Atherosclerosis inhibits platelet aggregation, promotes the effects of hemoglobin and RBC acceptor garland rate and antalgic and inflammation relieving.

The rhizome of davallia is the dry rhizome of Plants of Polypodiaceae Mongolian oak fern；Its bitter, temperature；Return liver and kidney channel.The rhizome of davallia, which has, to be treated The effect of wound analgesic, reunion of bone and The strong bone of kidney tonifying；It is primarily useful for falling winks frustrates, injured bone, lumbago due to the kidney deficiency, muscles and bones impotence The effect of soft, Hiccough and deaf and tooth mobility.Pharmaceutical research shows that it has and promotes rat bone wound healing, stimulation Bones and joints The effects of cartilage cell's compensatory hypertrophy and improvement articular cartilage retrogression pathological changes.

Herba Epimedii is the dried leaf of Berberidaceae plant Herba Epimedii, Epimedium sagittatum, E. Pubescens or korean epimedium herb； Its taste acrid, sweet, warm；Return liver and kidney channel.Herba Epimedii has effects that kidney-replenishing, strengthening the bones and muscles and wind-damp dispelling；It is primarily useful for kidney-yang deficiency It declines, muscles and bones impotence, rheumatic arthralgia and numbness contracture etc..Pharmaceutical research shows that Herba Epimedii has decompression, reducing blood lipid, anti-inflammatory and increasing The effects of strong immune.

Puncture multitude is pierced, is the fruit of zygophyllaceae plant puncture vine；Its bitter is acrid in flavour and warm in nature；Enter liver, lung channel.Pierce puncture multitude have town liver wind, The effect of dissipating irascibility, relieve heat, lower gas and promoting circulation of blood；It is primarily useful for controlling headache, fullness sensation in chest, cough Ni, lumps in the chest and abdomen, ulcer etc..《Book on Chinese herbal medicine It converges and says》：Tribulus terrestris removes gas under wind, the medicine of row aquation disease.It, which is declared, leads to fastly just, and energy capacity disappears, and row liver and spleen stagnant gas takes long term usage more, There is stagnant function.Pharmaceutical research shows that piercing puncture multitude has the function of anti arteriosclerosis and platelet aggregation-against.

The present invention is directed to the characteristics of caput femoris necrosis syndrome of blood stasis and stagnant qi using blood circulation and removing stasis, promoting qi circulation and relieving pain, soothing liver-qi stagnation, treatment The continuous folding of wound strengthens muscles and bones and the therapies such as invigorating QI and blood.

In the raw material of the Chinese medicine composition for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi of the invention, rhizoma corydalis has promoting blood circulation row The effect of gas relieves pain, can the stagnation of the circulation of vital energy in promoting circulation of blood；Fennel seeds have effects that eliminating cold to stop pain qi-regulating.The two medicines phase 5, have promoting blood circulation by The effect of stasis of blood, promoting qi circulation and relieving pain and soothing liver-qi stagnation, and two medicines walk Liver Channel, can treat hernia pain, occur with caput femoris necrosis Groin midpoint pain position is identical, is suitable for caput femoris necrosis syndrome of blood stasis and stagnant qi especially, is altogether monarch drug in a prescription.

Artemisia anomala has effects that broken stasis of blood promoting menstruation, continuous folding of curing the wound, promoting circulation of blood analgesic and detumescenceization product；There is Radix Paeoniae Alba blood-nourishing to hold back yin The effect of muscular constricture and analgesic of soft liver, is alleviated in hidroschesis, promoting circulation of blood stagnation resolvation；Herba Lycopi has promoting blood circulation, continuous folding of curing the wound, inducing diuresis for removing edema, leads to Long the effect of product, sharp tendon and vessel, nourish blood gas, eliminating mass lump in the abdomen, myogenic of putting on flesh；Radix paeoniae rubra has soothing liver-qi stagnation, clearing heat and cooling blood and removing blood stasis and acesodyne The effect of；Radix Angelicae Sinensis has effects that replenishing and activating blood, menstruction regulating and pain relieving, curing the wound continues folding, relieving rigidity of muscles and joints and control muscular constricture.It is above altogether ministerial drug, Not only had effects that, cure the wound continuous folding and soft liver promoting qi circulation and relieving pain stagnant by stasis of blood row, but also energy invigorating QI and blood, myogenic are put on flesh and easing joint movement muscle Arteries and veins.

The rhizome of davallia has effects that cure the wound analgesic, reunion of bone and The strong bone of kidney tonifying；Herba Epimedii have kidney-replenishing, strengthening the bones and muscles and The effect of except numbness pain, solution muscular constricture.Two medicine shares, and is altogether adjutant, has the continuous folding that strengthens muscles and bones and cure the wound, the function of eliminating impediment and relieving pain Effect.

There is thorn puncture multitude gas under purge the green, relieve heat, promoting circulation of blood to go stagnant, the effect of going wind to invigorate blood circulation, can enhance monarch drug in a prescription effect and All medicines can be drawn to guide drugs to illness station, as making medicine.

It should be noted that often occurring the pain at position where femoral head, physical examination in caput femoris necrosis repair process Show as groin midpoint pain.Herein according to the meridian theory of Chinese medicine be Liver Channel where position, also with indirect inguinal hernia pain Position is identical.Rhizoma corydalis, fennel seeds, tribulus terrestris etc. enter Liver Channel in the present invention, can priming object guide drugs to illness station, therefore it is of the invention Chinese medicine composition can work to groin midpoint pain relieving rapid.

In conclusion the Chinese medicine composition for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi of the invention selects natural Chinese traditional medicines former Material, using rhizoma corydalis and fennel seeds as monarch drug in a prescription, with Artemisia anomala, Radix Paeoniae Alba, radix paeoniae rubra, Herba Lycopi, when being classified as ministerial drug, with the rhizome of davallia and excessive sheep The leaves of pulse plants is adjutant, is to make medicine with tribulus terrestris, comprehensively utilizes the Action advantage of above-mentioned each Chinese herb and mutually acts synergistically, promoting blood circulation By the stasis of blood and soothing the liver promoting the circulation of qi phase 5, qi and blood is simultaneously adjusted, and not only promoting circulation of blood divided the stasis of blood stagnant, but also a point pent-up of venting one's spleen；Dissolving stasis, with applying, is invigorated blood circulation and nothing with blood-nourishing The worry of hematozemia, promoting the circulation of qi and the disadvantage without impairment of yin；Not only had effects that blood circulation and removing stasis, promoting qi circulation and relieving pain and soothing liver-qi stagnation, but also had and cure the wound Continuous folding strengthens muscles and bones and the effect of invigorating QI and blood, tonification and purgation in combination, giving consideration to both the incidental and fundamental；Both it had been directed to the entirety of femoral head syndrome of blood stasis and stagnant qi Performance, and guided drugs to illness station with Liver Channel drug and tying-in drug, the part of caput femoris necrosis is looked after, for caput femoris necrosis blood stasis Syndrome of qi stagnation is significant in efficacy, easy to use.

Preferably, the rhizoma corydalis is 201~225 parts；The fennel seeds are 131~151 parts.

Preferably, the Artemisia anomala is 68~78 parts；The Radix Paeoniae Alba is 90~100 parts；The Herba Lycopi is 88~98 parts；Institute Stating radix paeoniae rubra is 90~100 parts；It is described to be classified as 88~98 parts.

Preferably, the rhizome of davallia is 68~78 parts；The Herba Epimedii is 68~78 parts；The tribulus terrestris is 41~49 Part.

More preferably, the rhizoma corydalis is 213 parts；The fennel seeds are 141 parts；The Artemisia anomala is 73 parts；The Radix Paeoniae Alba It is 95 parts；The Herba Lycopi is 93 parts；The radix paeoniae rubra is 95 parts；It is described to be classified as 93 parts；The rhizome of davallia is 73 parts；The excessive sheep The leaves of pulse plants is 73 parts；The tribulus terrestris is 45 parts.

Preferably, 2.5~3.5 parts such as 2.5 parts, 2.8 parts, 3 parts, 3.2 have been additionally added in every 100 parts of Chinese medicine compositions Part or 3.5 parts of starch.Preferably, 2 parts of starch and 15 parts of honey have been additionally added in every 100 parts of Chinese medicine compositions.

The preparation method further includes mixing 100 parts of powders, 2.5~3.5 parts of starch and 28~42 parts of pure water Wet ball is made after stirring.

Preferably, by the wet ball drying to moisture 5% (weight) below to obtain vegetable pill, and the vegetable pill is active Charcoal bag charcoal clothing and with talcum powder polishing, wherein every 100 parts of vegetable pills using 0.45~0.55 part such as 0.45 part, 0.48 part, Such as 0.45 part, 0.48 part, 0.5 part, 0.52 part or 0.55 of 0.5 part, 0.52 part or 0.55 part active carbon and 0.45~0.55 part Part talcum powder.

Chinese medicine composition and its pill of the invention is had no toxic side effect using safe.Because pill production is simple, easily take With, easy to carry, when preparation, can be not added or less plus auxiliary material, and it is at low cost, it is suitable for mass production, therefore dosage form is preferably pill.Certainly, It can according to need and other dosage forms, such as tablet, capsule, granule etc. are made.

To facilitate the understanding of the present invention, technical side of the invention is further illustrated below with reference to embodiment and specific case Case.

Embodiment 1

(1) Chinese medicine material is weighed：197 parts of rhizoma corydalis, 155 parts of fennel seeds, 64 parts of Artemisia anomala, 86 parts of Radix Paeoniae Alba, 84 parts of Herba Lycopi, 104 parts of radix paeoniae rubra, 102 parts of Radix Angelicae Sinensis, 64 parts of the rhizome of davallia, 82 parts of Herba Epimedii, 37 parts of tribulus terrestris.

(2) above-mentioned each Chinese medicine material is ground into carefully with TF300B type Double-grade disintegrating mill (production of Tianjin Chinese traditional medicine machine factory) It is equal to be subsequently placed in mixing in the efficient three-dimensional motion mixer of GH-200 type (production of Harbin medication chemistry equipment Co., Ltd) for powder It is even to get powder.

(3) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 type trough type mixing machine The production of equipment Science and Technology Ltd.) in, 2.5 parts of starch are first added and are stirred 15min, add 28 parts of pure water stir abouts 25min obtains softwood.

(4) above-mentioned softwood is placed in YUJ-17B type intelligent and high-efficiency full automatic machine for producing pills (Tianshui city Hua Yuan pharmaceutical equipment section The production of skill Co., Ltd) in tie rod, rub ball with the hands, obtain that rounding is uniform, the consistent wet ball of appearance, diameter is 4.0~4.3mm.

(5) the wet ball of above-mentioned preparation is placed in HWL15-1 microwave drying sterilization case (Tianshui city China garden pharmaceutical equipment science and technology Co., Ltd's production) under the conditions of 45 DEG C of hot winds, 90 DEG C of the temperature inside the box, it is 60 minutes dry, solid carbon dioxide point is obtained in 5% element below Ball.

(6) above-mentioned vegetable pill is placed in the coating pan of TG~1000 (production of Tianshui city Hua Yuan pharmaceutical equipment Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.45 part of active carbon, talcum powder, obtain pill.

Embodiment 2

(1) Chinese medicine material is weighed：199 parts of rhizoma corydalis, 153 parts of fennel seeds, 66 parts of Artemisia anomala, 88 parts of Radix Paeoniae Alba, 86 parts of Herba Lycopi, 102 parts of radix paeoniae rubra, 100 parts of Radix Angelicae Sinensis, 66 parts of the rhizome of davallia, 80 parts of Herba Epimedii, 39 parts of tribulus terrestris.

(3) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 type trough type mixing machine The production of equipment Science and Technology Ltd.) in, 2.8 parts of starch are first added and are stirred 15min, add 30 parts of pure water stir abouts 25min obtains softwood.

(6) above-mentioned vegetable pill is placed in the coating pan of TG~1000 (production of Tianshui city Hua Yuan pharmaceutical equipment Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.48 part of active carbon, talcum powder, obtain pill.

Embodiment 3

(1) Chinese medicine material is weighed：201 parts of rhizoma corydalis, 151 parts of fennel seeds, 68 parts of Artemisia anomala, 90 parts of Radix Paeoniae Alba, 88 parts of Herba Lycopi, 100 parts of radix paeoniae rubra, 98 parts of Radix Angelicae Sinensis, 68 parts of the rhizome of davallia, 78 parts of Herba Epimedii, 41 parts of tribulus terrestris.

(3) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 type trough type mixing machine The production of equipment Science and Technology Ltd.) in, 3 parts of starch are first added and are stirred 15min, add 35 parts of pure water stir about 25min, Obtain softwood.

(6) above-mentioned vegetable pill is placed in the coating pan of TG~1000 (production of Tianshui city Hua Yuan pharmaceutical equipment Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.52 part of active carbon, talcum powder, obtain pill.

Embodiment 4

(1) Chinese medicine material is weighed：205 parts of rhizoma corydalis, 145 parts of fennel seeds, 70 parts of Artemisia anomala, 92 parts of Radix Paeoniae Alba, 90 parts of Herba Lycopi, 98 parts of radix paeoniae rubra, 93 parts of Radix Angelicae Sinensis, 70 parts of the rhizome of davallia, 75 parts of Herba Epimedii drink 43 parts of tribulus terrestris.

(3) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 type trough type mixing machine The production of equipment Science and Technology Ltd.) in, 3 parts of starch are first added and are stirred 15min, add 40 parts of pure water stir about 25min, Obtain softwood.

Embodiment 5

(1) Chinese medicine material is weighed：213 parts of rhizoma corydalis, 141 parts of fennel seeds, 73 parts of Artemisia anomala, 95 parts of Radix Paeoniae Alba, 93 parts of Herba Lycopi, 95 parts of radix paeoniae rubra, 93 parts of Radix Angelicae Sinensis, 73 parts of the rhizome of davallia, 73 parts of Herba Epimedii, 45 parts of tribulus terrestris.

(3) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 type trough type mixing machine The production of equipment Science and Technology Ltd.) in, 3.5 parts of starch are first added and are stirred 15min, add 35 parts of pure water stir abouts 25min obtains softwood.

Embodiment 6

(1) Chinese medicine material is weighed：219 parts of rhizoma corydalis, 135 parts of fennel seeds, 75 parts of Artemisia anomala, 98 parts of Radix Paeoniae Alba, 95 parts of Herba Lycopi, 92 parts of radix paeoniae rubra, 90 parts of Radix Angelicae Sinensis, 75 parts of the rhizome of davallia, 70 parts of Herba Epimedii, 47 parts of tribulus terrestris.

(3) 100 parts of above-mentioned powders being prepared is taken to be placed in (the Tianshui city China garden pharmacy of CHJ-200 type trough type mixing machine The production of equipment Science and Technology Ltd.) in, 3.2 parts of starch are first added and are stirred 15min, add 42 parts of pure water stir abouts 25min obtains softwood.

(6) above-mentioned vegetable pill is placed in the coating pan of TG~1000 (production of Tianshui city Hua Yuan pharmaceutical equipment Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.55 part of active carbon, talcum powder, obtain pill.

Embodiment 7

(1) Chinese medicine material is weighed：225 parts of rhizoma corydalis, 131 parts of fennel seeds, 78 parts of Artemisia anomala, 100 parts of Radix Paeoniae Alba, Herba Lycopi 98 Part, 90 parts of radix paeoniae rubra, 88 parts of Radix Angelicae Sinensis, 78 parts of the rhizome of davallia, 68 parts of Herba Epimedii, 49 parts of tribulus terrestris.

(6) above-mentioned vegetable pill is placed in the coating pan of TG~1000 (production of Tianshui city Hua Yuan pharmaceutical equipment Science and Technology Ltd.) Middle packet charcoal clothing, talcum powder polishing, every 100 parts of vegetable pills can be added each 0.5 part of active carbon, talcum powder, obtain pill.

Embodiment 8

(1) Chinese medicine material is weighed：227 parts of rhizoma corydalis, 129 parts of fennel seeds, 80 parts of Artemisia anomala, 102 parts of Radix Paeoniae Alba, Herba Lycopi 100 Part, 88 parts of radix paeoniae rubra, 86 parts of Radix Angelicae Sinensis, 80 parts of the rhizome of davallia, 66 parts of Herba Epimedii, 51 parts of tribulus terrestris.

Embodiment 9

(1) Chinese medicine material is weighed：229 parts of rhizoma corydalis, 127 parts of fennel seeds, 82 parts of Artemisia anomala, 104 parts of Radix Paeoniae Alba, Herba Lycopi 102 Part, 86 parts of radix paeoniae rubra, 84 parts of Radix Angelicae Sinensis, 82 parts of the rhizome of davallia, 64 parts of Herba Epimedii, 53 parts of tribulus terrestris.

Comparative example 1

As different from Example 5, the dosage of rhizoma corydalis is 190 parts, and the dosages of fennel seeds is 170 parts, other compositions and Preparation method is same as Example 5.

Comparative example 2

As different from Example 5, the dosage of Artemisia anomala is 50 parts, and the dosage of Radix Paeoniae Alba is 120 parts of other compositions and preparation Method is same as Example 5.

Comparative example 3

As different from Example 5, the dosage of Herba Lycopi is 80 parts, and the dosage of radix paeoniae rubra is 120, other compositions and preparation method It is same as Example 5.

Comparative example 4

As different from Example 5, the dosage of Radix Angelicae Sinensis is 70 parts, and the dosage of the rhizome of davallia is 90 parts, other compositions and preparation Method is same as Example 5.

Comparative example 5

As different from Example 5, the dosage of Herba Epimedii is 58 parts, and the dosage of thorn puncture multitude is 60 parts, other compositions and system Preparation Method is same as Example 5.

It is as follows that compliance test result is carried out to the pill for the treatment of caput femoris necrosis of the invention：

By the patient of 450 caput femoris necrosis, the age is 18~65 years old, is randomly divided into 9 groups, originally by above-mentioned application method The Chinese medicine composition of inventive embodiments 1~9 is treated.

The following diagnostic criteria judgement of the patient of above-mentioned 450 caput femoris necrosis：

Referring to 2015《Caput femoris necrosis clinic diagnosis specification-plum is flourish》Middle caput femoris necrosis diagnostic criteria.

A. have long-term a large amount of excessive drinking histories, using Adrenal Glucocorticoid history, hip trauma history more.

B. symptom is mainly hip arthralgia, and early function is normal or only outreach and interior receipts is slight limited, the test of " 4 " word The positive, with progression of the disease hip abduction and anteflexion, interior outward turning can be limited obviously, until hip joint function completely loses.

C.X line piece：Necrosis region is hardened band wrapping, segmental, meniscus sign, collapse of femoral head but joint space dimension It holds.

d.MRI：Diagnose the goldstandard of caput femoris necrosis.T1WI:Band-like low signal wraps fatty (middle high RST) or necrosis Bone (middle signal) is caput femoris necrosis typical image.T2W1：Two-wire sign, T2W1 press rouge：Femoral head and cervix removes focal zone bone marrow Oedema and the band-like low signal of T1WI.

Case is included in and exclusion criteria：

1. case selection and being included in standard

A. subject signs informed consent form；

B. it is diagnosed as the diagnosis of caput femoris necrosis doctor trained in Western medicine, and ARCO locates I, II, III-a phase by stages；

C., the patient of the state of an illness can independently be described；

D. inpatient.

2. case exclusion criteria

A. merge patient, tumour of severe osteoporosis, severe hypertension and serious cardio-cerebrovascular disorder etc. or mental disease Patient；

B. hip joint function obstacle caused by the other reasons such as osteomyelitis, bone tumour, bone tuberculosis；

C. merge unstable joint, non-union bone fractures, arthroncus, after artificial joint replacement, undue pain, joint it is living It is dynamic to spend the patient to become larger；

D. patient compliance difference or refusal participate in the patient of this research；

E. other clinical trial persons are being participated in；

F. gestation or nursing period obtain female patient.

Curative effect judgement：

The research of hip method for estimating curative effect is protected with reference to Harris grade form, hip VAS scoring, the caput femoris necrosis based on x-ray Deng formulation the standard of curative effect evaluation.Harris scoring symptom mitigates calculation method：Improvement degree=(before treatment post-treatment)/treatment Before × 100%.VAS scoring improves level calculating method：Improvement degree=and (before treatment-after treatment)/before treating × 100%.

It cures：Symptom and sign disappears substantially, and Harris, VAS score improvement degree in 51%-100%.

Effectively：Symptom and sign is alleviated, and Harris, VAS score improvement degree in 26%-50%.

In vain：Without improvement before symptom and sign and treatment, Harris, VAS score improvement degree below 25%.

Application method：It is oral, a 6g, 3 times a day；10 days as a treatment course, be used continuously 3 courses for the treatment of it is of the invention in After drug composition, statistical result such as the following table 1：

Table 1

By upper table 1 it is found that after the traditional chinese medicine composition of the invention is treated, work well, efficient 84% or more, cure rate Up to 70% or more, it can be seen that, pill of the invention has preferable effect to the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi.Separately Outside, in general from cure rate and effective percentage, the therapeutic effect of embodiment 5 is best.

In addition, inventor also utilizes pill made of comparative example 1~5 respectively to 8 groups of patients (every group of 10 caput femoris necrosis Patient, the age be 18~65 years old) treated, all without therapeutic effect or therapeutic effect it is very poor (effective percentage not More than 50%).

Clinical case 1：Liu, male, 24 years old, Anhui Province people from Lixin County.Patient occurred right hip pain in 2 months 2014 Bitterly, limitation of activity, it is then medical to Zhongshan Hospital, Xiamen City, be diagnosed as right side caput femoris necrosis after inspection, give anti-inflammatory analgetic and Blood-activating stasis-removing kind drug oral is not apparent from improvement, and rear hip is still interrupted pain, and limitation of activity aggravates, and in 2016 in Zhengzhou Guan Cheng institute of traditional Chinese medicine of city is hospitalized complex treatment, and specifically unknown, rear right hip is still interrupted pain, limitation of activity.On October 27th, 2017 enters Firmly our hospital, be admitted to hospital symptoms include：Walk lamely, squat down limited, right hip is ached, and right knee pain, limitation of activity, mind is clear, spirit can, two Just it adjusts, tongue purple is dim, and tongue fur is thin white, stringy and hesitant pulse.

Training inspection：Double lower limb pneumonedema, skin temperature is normal, right side groin midpoint tenderness, percussion pain at the greater trochanter of right side, double Lower limb power is III grade left, IV grade of right side, and right side Thomas sign is positive, and the test of bilateral " 4 " word is positive, and allis' sign is negative, and double hips are living Dynamic degree：It is 40 ° of left side outreach, interior to receive 20 °, 140 ° of buckling, 20 ° of inward turning, 30 ° of outward turning, 20 ° of right side outreach, interior to receive 15 °, buckling 80 °, 5 ° of inward turning.Double lower limb length：Left side 90cm, right side 91cm, 10cm weeks diameter on kneecap：Left side 43cm, right side 41cm.

Auxiliary examination：The positive axle position of pelvis, right knee positive side position DR (2017.10.27 068873)：Right lateral thigh bone form becomes It is flat, bone density unevenness is shown in femoral head, bone trabecula is fuzzy, it is seen that capsule sample low-density shadow and patch shape increase in density shadow, right side The visible osteoproliferation of femoral head periphery, right hip joint space slightly narrow, and left hip joint is shown no obvious abnormalities.Right knee space is slightly Narrow, Patellar joint gap is fine.Double hip MRI (2017.10.27 11835) are shown：1. right side avascular necrosis of femoral head；2. pair Hip joint hydrops；3. abnormal signal at left femur greater trochanter muscle attachment considers inflammation；4. right side femoral head hyperostosis It is raw.

Tentative diagnosis：Tcm diagnosis：Bone erosion, syndrome of blood stasis and stagnant qi；Doctor trained in Western medicine diagnosis：1. (ARCO is by stages for right side caput femoris necrosis： IV phase) 2. Hip osteoarthritis.

The pill of the preparation of the embodiment of the present invention 1 is taken, is taken orally, 3 times a day, each 6g.Patient's hip pain after a week Mitigate, function is not improved, and patient's pain mitigates earlier above after 2 weeks, and functional activity degree improves earlier above, and vital sign is steady, is suffered from Person requires discharge.Continue to take pill prepared by the embodiment of the present invention 1 after discharge, takes regular exercise, hormone, periodic review liver is used with caution Kidney function.It is checked after three months, basic without pain, functional activity is good, can normal life.

Clinical case 2：Liu, male, 10 years old, Han nationality, Henan Province Puyang people from counties and cities.Patient is in September, 2015 without obvious There is right knee paroxysmal pain in inducement, walks lamely, until local hospital row MRI inspection is thought of as growth Normal appearances, oral drugs (tool Body is unknown) 4 days pain are without alleviation.Half a year is treated with " necrosis of right side femoral head epiphysis " row abduction frame to Luoyang bonesetting hospital afterwards, Pain is mitigated.On October 12nd, 2017 moves in our hospital.Be admitted to hospital symptoms include：It walks lamely, squats down still, right hip pain, mind is clear, Spirit can, receive dormancy can, two is just normal, and tongue is dim petechia, and tongue fur is thin white, stringy and hesitant pulse.

Training inspection：Squat down can, right side iliac region, gluteus medius are without tenderness, and greater trochanter of femur is without percussion pain, double lower limb etc. It is long, double lower limb muscular strength：III grade of right side, left side is normal.Double ankle maximum spacing 110cm, 10cm flesh Zhou Jing on kneecap：The equal 31cm of bilateral. Double hip joint mobility：130 ° of right lateral flexion, 5 ° of inward turning, 10 ° of outward turning, outreach adduction is normal, and left side mobility can.The examination of " 4 " word It is positive to test the negative right side in left side, full Deng Baozheng：The positive right side in left side is negative, and Thomas's base sign is negative, and allis' sign is negative.

Auxiliary examination:Pelvis positive axis bit slice (2017.10.12 062523) shows：Show bone density in the femoral head epiphysis of right side Unevenly, bone trabecula is fuzzy, it is seen that capsule sample low-density shadow；Right side femoral head epiphysis form becomes flat, and hip joint space is fine；Left hip Non Apparent Abnormality.

Tentative diagnosis：Tcm diagnosis：Bone erosion, stagnation of QI and blood；Doctor trained in Western medicine diagnosis：Right side femoral head epiphysis is downright bad (II type).

Every pill for checking, preparing using the embodiment of the present invention 2 is improved after being admitted to hospital, and is taken orally, 3 times a day, each 6g.Clothes After pill 2 weeks of the preparation of the embodiment of the present invention 2, patient tells that right hip pain is substantially reduced earlier above, and hip joint function changes earlier above Kind, ordinary circumstance is good, and whole sb.'s illness took a favorable turn, patient requests' discharge, permits its discharge through higher level doctor's approval.After discharge pay attention to after The continuous pill for taking the preparation of the embodiment of the present invention 2, and adhere to leaning on crutches walking, untired, anti-wound, appropriate functional training.Three It is checked after a month in the court, for hip substantially without pain, functional activity is good, can meet daily life, and hepatic and renal function is without exception.

Clinical case 3：It is high so-and-so, gender male, the age 42 years old, national Han nationality, address：Henan Province people from Dancheng County.Patient It walks lamely when in December, 2015 walking, with right hip arthralgia, is in duration shouting pain, can reduce after rest, do not give treatment. Pain in January, 2016 aggravates, medical in local hospital, and MRI is diagnosed as right side caput femoris necrosis after checking, right hip joint hydrops, It is ineffective after oral drugs.Then our hospital is moved on March 11st, 2016.Be admitted to hospital symptoms include：It walks lamely, right hip arthralgia is squatted down Limited, functional activity is limited, long row, it is tired after aggravate, receive dormancy can, two just adjust, and tongue purple is dim, and tongue fur is thin white, stringy and hesitant pulse.

Training inspection：Right side groin midpoint tenderness, right side greater trochanter percussion pain, IV grade of right lower extremity muscular strength, horse is held in the palm on right side This sign is positive, and the test of " 4 " word is positive, and allis' sign is positive, and full Deng Baozheng is negative.

Auxiliary examination：The positive axle position DR (2016.3.11 062470) of pelvis：Right lateral thigh bone form becomes flat, shows in femoral head Density inhomogeneity, bone trabecula are fuzzy, it is seen that capsule sample low-density shadow and patch shape increase in density shadow, right hip gap is fine, and left hip is not See exception.Double hip joint MRI (2016.2.11 61551)：1. right side avascular necrosis of femoral head；2. right hip joint hydrops；3. Right femur upper segment bone marrow edema.

Tentative diagnosis：Tcm diagnosis：Bone erosion, stagnation of QI and blood；Doctor trained in Western medicine diagnosis：Right side caput femoris necrosis (III phase).

Every inspection is improved after being admitted to hospital, according to tcm treatment according to syndrome differentiation, the pill prepared using the embodiment of the present invention 3 is oral, 3 times a day, each 6g.On March 24th, 2016, patient's ordinary circumstance is good, and right hip pain is substantially reduced, hip joint activity function It can improve, patient requests' discharge, permit its discharge through higher level doctor's approval.Continue to take the preparation of the embodiment of the present invention 3 after discharge Pill oral medication, periodic review liver function, kidney function adhere to that leaning on crutches walks, and appropriate functional training is not tired, and anti-wound is used with caution Hormone.Checked after three months in the court, for hip substantially without pain, functional activity is good, do not influence daily life, hepatic and renal function without It is abnormal.

Clinical case 4：Qi so-and-so, female, the age 50 years old, national Han nationality, Anhui Province people from Suixi County.Patient is in 2007 without bright There are double hip pains discomforts in aobvious inducement, out of strength with function limitation, does not give treatment.Double hips are interrupted pain afterwards, and limitation of activity aggravates, It is checked to local hospital MRI in April, 2017 and is diagnosed as bilateral femoral head necrosis recklessly, it is proposed that hip replacement, patient's refusal.It is double afterwards Hip pain aggravates, and functional activity is limited.After move in our hospital, be admitted to hospital symptoms include：It walks lamely, difficulty of squatting down, double hips are ached with active receiving Limit, mind is clear, spirit can, receive dormancy can, two is just normal, and tongue is dark red petechia, and tongue fur is thin white, stringy and hesitant pulse.

Training inspection：Double hip joint mobility：Right side：400 ° of buckling, extend back 5 °, it is interior to receive 5 °, 5 ° of outreach, 0 ° of inward turning, outside 0 ° of rotation, left side：30 ° of buckling, 5 ° are extended back, interior 5 °, 5 ° of outreach, 0 ° of inward turning, 0 ° of outward turning of receipts.II grade of bilateral inguinal midpoint tenderness, The test of bilateral " 4 " word is positive, and Thomas's base sign is positive, and allis' sign is positive, double lower limb muscular strength：IV grade of left side, IV grade of right side.

Auxiliary examination：Pelvis positive axis bit slice (2017.11.19 069107) shows：Bilateral femoral head form becomes flat, in head mortar Show bone density unevenness, bone trabecula is fuzzy, it is seen that capsule sample low-density shadow and patch shape increase in density shadow, bilateral femoral head and acetabular bone The visible osteoproliferation shadow of periphery, double hip joint gap turn narrow, remaining no abnormality seen.Double hip joint MRI (2017.11.19 12586) Show：1. bilateral femoral head and acetabular bone ischemic necrosis；2. bilateral hip joint characteristic of stock arthritis；3. abnormal uterine, myomata.

Tentative diagnosis：Tcm diagnosis：Bone erosion, stagnation of QI and blood；Doctor trained in Western medicine diagnosis：1. bilateral femoral head necrosis (the equal ARCO in left and right IV phase) 2. double hip joint Osteoarthritis.

Every inspection is improved after being admitted to hospital, and according to tcm treatment according to syndrome differentiation, the pill prepared using the embodiment of the present invention 4, mouth Clothes, 3 times a day, each 6g.On December 1st, 2017, patient's ordinary circumstance is good, and hip pain is substantially reduced compared with when being admitted to hospital, function Movable it can improve earlier above, the state of an illness integrally improves, patient requests' discharge.Adhere to that leaning on crutches walks after discharge, appropriate functional training, not Fatigue, anti-wound, is used with caution hormone, continues to take drug oral treatment of the present invention, periodic review liver function, kidney function.After three months in The court's check, hip pain is lighter, and functional activity is fine, has substantially no effect on daily life, and hepatic and renal function is without exception.

Clinical case 5：Field so-and-so, male, 47 years old, national Han nationality, Anhui Province people from Changfeng County.Patient obviously lured in nothing in 2012 Because there is left hip pain, treatment is not given.Afterwards toss about mostly see a doctor, in 2013 105 hospital diagnosis of liberation army be femoral head Treatment is not given in necrosis.On June 20th, 2017 moves in our hospital, be admitted to hospital symptoms include：It walks lamely, left hip interruption pain, companion's function limitation, Squat down difficulty, mind is clear, spirit can, receive dormancy can, two just adjust, and two is just normal, and tongue is dark red, and tongue fur is thin white, stringy and hesitant pulse.

Training inspection：Left side groin midpoint tenderness is obvious, without tenderness and percussion pain, left side gluteus medius at bilateral greater trochanter Tenderness, the test of bilateral " 4 " word is negative, and Thomas sign is negative, and allis' sign is negative, and positive right side is negative on the left of full Deng Baozheng, III grade of right side is normal on the left of double lower limb muscular strength, 10cm flesh week diameter 42cm on double lower limb kneecap, double ankle maximum spacing 129cm, and double hips are living Dynamic degree：Left side：130 ° of buckling, 20 ° of outward turning, 25 ° of inward turning, outreach, interior receipts are normal, and right hip joint mobility is normal.

Auxiliary examination：Pelvis positive axis bit slice (2017.6.20 049893) shows：Show bone density unevenness in bilateral femoral head, It can be seen that capsule sample low-density shadow, left femur head morphology becomes flat, and femoral head border science and technology loves your osteoproliferation shadow, between bilateral hip joint Gap is fine.Double hip joint MRI (2017.6.20) shows：1. bilateral femoral head ischemic necrosis；2. a small amount of hydrops of double hip joint chamber.

Tentative diagnosis：Tcm diagnosis：Bone erosion, stagnation of QI and blood；Doctor trained in Western medicine diagnosis：(ARCO III phase an of left side is right for bilateral femoral head necrosis II phase).

Every inspection is improved after being admitted to hospital, according to tcm treatment according to syndrome differentiation, the pill prepared using the embodiment of the present invention 5 is oral, 3 times a day, each 6g.After taking 6 days, groin midpoint tenderness, left side gluteus medius tenderness mitigate on the left of patient, left hip joint 135 ° of buckling, rotation is 25 ° outer, improves earlier above, and function improves, patient requests' discharge.Adhere to leaning on crutches walking, appropriate function after discharge It takes exercise, untired, hormone is used with caution in anti-wound, continues to take drug oral treatment of the present invention, periodic review liver function, kidney function.Three It is checked after month in the court, for hip substantially without pain, functional activity is good, does not influence daily life, and hepatic and renal function is without exception.

It should be noted that the pill for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi prepared by the embodiment of the present invention 1~5 is replaced It is changed to the medicine pill of the treatment caput femoris necrosis syndrome of blood stasis and stagnant qi of the preparation of the embodiment of the present invention 6~9, can reach above-mentioned same Experiment effect.

The above is only a preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art For member, inventive formulation and preparation process can have various modifications and variations.All within the spirits and principles of the present invention, institute Any modification, equivalent substitution, improvement and etc. of work, should all be included in the protection scope of the present invention.

Claims

1. a kind of Chinese medicine composition for treating caput femoris necrosis syndrome of blood stasis and stagnant qi, it is characterised in that：Include following parts by weight Raw material：197~229 parts of rhizoma corydalis, 127~155 parts of fennel seeds, 64~82 parts of Artemisia anomala, 86~104 parts of Radix Paeoniae Alba, Herba Lycopi 84~ 102 parts, 86~104 parts of radix paeoniae rubra, 84~102 parts of Radix Angelicae Sinensis, 64~82 parts of the rhizome of davallia, 64~82 parts of Herba Epimedii and thorn puncture multitude 37~53 Part.

2. the Chinese medicine composition for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi according to claim 1, it is characterised in that：It is described Rhizoma corydalis is 201~225 parts；The fennel seeds are 131~151 parts.

3. the Chinese medicine composition for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi according to claim 1, it is characterised in that：It is described Artemisia anomala is 68~78 parts；The Radix Paeoniae Alba is 90~100 parts；The Herba Lycopi is 88~98 parts；The radix paeoniae rubra is 90~100 parts； It is described to be classified as 88~98 parts.

4. the Chinese medicine composition for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi according to claim 1, it is characterised in that：It is described The rhizome of davallia is 68~78 parts；The Herba Epimedii is 68~78 parts；The tribulus terrestris is 41~49 parts.

5. the Chinese medicine composition for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi according to claim 1, it is characterised in that：It is described Rhizoma corydalis is 213 parts；The fennel seeds are 141 parts；The Artemisia anomala is 73 parts；The Radix Paeoniae Alba is 95 parts；The Herba Lycopi is 93 Part；The radix paeoniae rubra is 95 parts；It is described to be classified as 93 parts；The rhizome of davallia is 73 parts；The Herba Epimedii is 73 parts；The tribulus terrestris It is 45 parts.

6. a kind of pill for treating caput femoris necrosis syndrome of blood stasis and stagnant qi, it is characterised in that：The pill includes Claims 1 to 5 Any one of described in treatment caput femoris necrosis syndrome of blood stasis and stagnant qi Chinese medicine composition.

7. the pill for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi according to claim 6, it is characterised in that：Every 100 parts of institutes It states and has been additionally added 2.5~3.5 parts of starch in Chinese medicine composition.

8. a kind of preparation method for the pill for treating caput femoris necrosis syndrome of blood stasis and stagnant qi：It is characterized in that：The pill includes power Benefit require any one of 1~5 described in treatment caput femoris necrosis syndrome of blood stasis and stagnant qi Chinese medicine composition；The preparation method packet It includes：Powder is uniformly mixed so as to obtain after the raw material is crushed.

9. the preparation method of the pill for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi according to claim 8, it is characterised in that： Further include：Wet ball is made after 100 parts of powders, 2.5~3.5 parts of starch and 28~40 parts of pure water are mixed.

10. the preparation method of the pill for the treatment of caput femoris necrosis syndrome of blood stasis and stagnant qi according to claim 9, feature exist In：By the wet ball drying to moisture 5wt% or less to obtain vegetable pill, and by the vegetable pill active charcoal bag charcoal clothing and use talcum Powder polishing, wherein every 100 parts of vegetable pills use 0.45~0.55 part of active carbon and 0.45~0.55 part of talcum powder.