CN108883131B - 调节髓源性抑制细胞的炎性小体活化用于治疗GvHD或肿瘤 - Google Patents
调节髓源性抑制细胞的炎性小体活化用于治疗GvHD或肿瘤 Download PDFInfo
- Publication number
- CN108883131B CN108883131B CN201680046264.8A CN201680046264A CN108883131B CN 108883131 B CN108883131 B CN 108883131B CN 201680046264 A CN201680046264 A CN 201680046264A CN 108883131 B CN108883131 B CN 108883131B
- Authority
- CN
- China
- Prior art keywords
- mdsc
- mdscs
- gvhd
- inflammasome
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/418—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0648—Splenocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2313—Interleukin-13 (IL-13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Developmental Biology & Embryology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210388064.8A CN114790447A (zh) | 2015-08-06 | 2016-08-05 | 调节髓源性抑制细胞的炎性小体活化用于治疗GvHD或肿瘤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562201990P | 2015-08-06 | 2015-08-06 | |
| US62/201,990 | 2015-08-06 | ||
| PCT/US2016/045739 WO2017024213A1 (en) | 2015-08-06 | 2016-08-05 | Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210388064.8A Division CN114790447A (zh) | 2015-08-06 | 2016-08-05 | 调节髓源性抑制细胞的炎性小体活化用于治疗GvHD或肿瘤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108883131A CN108883131A (zh) | 2018-11-23 |
| CN108883131B true CN108883131B (zh) | 2022-04-29 |
Family
ID=56686964
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680046264.8A Active CN108883131B (zh) | 2015-08-06 | 2016-08-05 | 调节髓源性抑制细胞的炎性小体活化用于治疗GvHD或肿瘤 |
| CN202210388064.8A Pending CN114790447A (zh) | 2015-08-06 | 2016-08-05 | 调节髓源性抑制细胞的炎性小体活化用于治疗GvHD或肿瘤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210388064.8A Pending CN114790447A (zh) | 2015-08-06 | 2016-08-05 | 调节髓源性抑制细胞的炎性小体活化用于治疗GvHD或肿瘤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10894061B2 (enExample) |
| EP (3) | EP3682889B1 (enExample) |
| JP (3) | JP6927499B2 (enExample) |
| CN (2) | CN108883131B (enExample) |
| AU (2) | AU2016303622B2 (enExample) |
| CA (1) | CA2993806A1 (enExample) |
| ES (2) | ES2789574T3 (enExample) |
| PT (1) | PT3682889T (enExample) |
| WO (1) | WO2017024213A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3682889B1 (en) * | 2015-08-06 | 2023-02-01 | Regents of the University of Minnesota | Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd |
| FR3100715B1 (fr) * | 2019-09-12 | 2023-09-29 | Francais Du Sang Ets | Utilisation de HDL dans la prophylaxie de la maladie du greffon contre l’hôte |
| WO2022216615A1 (en) * | 2021-04-05 | 2022-10-13 | Rhode Island Hospital | Compositions and methods for the prevention or treatment of rheumatoid arthritis |
| CN113707223A (zh) * | 2021-04-21 | 2021-11-26 | 吴安华 | 一种预测肿瘤炎性小体活性状态及治疗敏感性的基因集系统及方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010062990A1 (en) * | 2008-11-26 | 2010-06-03 | Mount Sinai School Of Medicine Of New York University | In vitro generation of myeloid derived suppressor cells |
| CN112646777A (zh) * | 2020-12-31 | 2021-04-13 | 广州医科大学 | 一种扩增髓系来源的抑制性细胞的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040136973A1 (en) | 2002-11-07 | 2004-07-15 | Eliezer Huberman | Human stem cell materials and methods |
| EP2300000A1 (en) | 2008-07-03 | 2011-03-30 | University of Massachusetts | Methods and compositions for reducing inflammation and treating inflammatory disorders |
| US8334101B2 (en) | 2008-09-26 | 2012-12-18 | University Of Massachusetts | Intracellular DNA receptor |
| US8951529B2 (en) | 2009-12-22 | 2015-02-10 | Icahn School Of Medicine At Mount Sinai | Methods of using small compounds to enhance myeloid derived suppressor cell function for treating autoimmune diseases |
| US20140377278A1 (en) | 2012-01-10 | 2014-12-25 | Yale University | Compositions and Methods for Assessing and Treating Inflammatory Diseases and Disorders |
| AR095882A1 (es) * | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
| JP6359013B2 (ja) | 2013-07-29 | 2018-07-18 | 国立大学法人 鹿児島大学 | 1,5−d−アンヒドロフルクトースを含むアポトーシス関連スペック様カード蛋白質の機能阻害薬 |
| LT3240801T (lt) * | 2014-12-31 | 2021-02-25 | Checkmate Pharmaceuticals, Inc. | Kombinuota navikų imunoterapija |
| JP6959865B2 (ja) * | 2015-01-21 | 2021-11-05 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ガイドとして自身のカルレティキュリンを使用して癌細胞を食べるマクロファージ |
| EP3682889B1 (en) * | 2015-08-06 | 2023-02-01 | Regents of the University of Minnesota | Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd |
| KR102599839B1 (ko) | 2015-11-13 | 2023-11-09 | 큐에프 테크놀로지스 에이에스 | 물을 모으기 위한 장치 및 방법 |
| GB201721185D0 (en) * | 2017-12-18 | 2018-01-31 | Nodthera Ltd | Sulphonyl urea derivatives |
-
2016
- 2016-08-05 EP EP20153949.1A patent/EP3682889B1/en active Active
- 2016-08-05 JP JP2018506141A patent/JP6927499B2/ja active Active
- 2016-08-05 CN CN201680046264.8A patent/CN108883131B/zh active Active
- 2016-08-05 PT PT201539491T patent/PT3682889T/pt unknown
- 2016-08-05 AU AU2016303622A patent/AU2016303622B2/en not_active Ceased
- 2016-08-05 EP EP16751781.2A patent/EP3331538B1/en active Active
- 2016-08-05 EP EP22215685.3A patent/EP4218776A3/en not_active Withdrawn
- 2016-08-05 WO PCT/US2016/045739 patent/WO2017024213A1/en not_active Ceased
- 2016-08-05 CN CN202210388064.8A patent/CN114790447A/zh active Pending
- 2016-08-05 CA CA2993806A patent/CA2993806A1/en active Pending
- 2016-08-05 ES ES16751781T patent/ES2789574T3/es active Active
- 2016-08-05 US US15/747,902 patent/US10894061B2/en active Active
- 2016-08-05 ES ES20153949T patent/ES2939534T3/es active Active
-
2020
- 2020-12-11 US US17/119,832 patent/US12234480B2/en active Active
-
2021
- 2021-07-19 JP JP2021118749A patent/JP7235259B2/ja active Active
-
2022
- 2022-09-09 AU AU2022228188A patent/AU2022228188A1/en not_active Abandoned
-
2023
- 2023-02-15 JP JP2023021455A patent/JP2023053338A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010062990A1 (en) * | 2008-11-26 | 2010-06-03 | Mount Sinai School Of Medicine Of New York University | In vitro generation of myeloid derived suppressor cells |
| CN112646777A (zh) * | 2020-12-31 | 2021-04-13 | 广州医科大学 | 一种扩增髓系来源的抑制性细胞的方法 |
Non-Patent Citations (1)
| Title |
|---|
| "The Nlrp3 inflammasome regulates acute graft-versus-host disease;Dragana Jankovic等;《Journal of Experimental Medicine》;20130923;第210卷(第10期);第1900页右栏第2段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3331538B1 (en) | 2020-03-11 |
| EP4218776A3 (en) | 2024-02-28 |
| EP4218776A2 (en) | 2023-08-02 |
| WO2017024213A1 (en) | 2017-02-09 |
| AU2016303622B2 (en) | 2022-07-07 |
| PT3682889T (pt) | 2023-03-09 |
| US12234480B2 (en) | 2025-02-25 |
| CN108883131A (zh) | 2018-11-23 |
| ES2939534T3 (es) | 2023-04-24 |
| ES2789574T3 (es) | 2020-10-26 |
| CN114790447A (zh) | 2022-07-26 |
| AU2016303622A8 (en) | 2018-05-31 |
| CA2993806A1 (en) | 2017-02-09 |
| JP2018536620A (ja) | 2018-12-13 |
| HK1256917A1 (en) | 2019-10-04 |
| US20180214483A1 (en) | 2018-08-02 |
| EP3682889B1 (en) | 2023-02-01 |
| JP7235259B2 (ja) | 2023-03-08 |
| US20210128612A1 (en) | 2021-05-06 |
| JP2023053338A (ja) | 2023-04-12 |
| EP3682889A1 (en) | 2020-07-22 |
| EP3331538A1 (en) | 2018-06-13 |
| JP6927499B2 (ja) | 2021-09-01 |
| AU2016303622A1 (en) | 2018-02-22 |
| AU2022228188A1 (en) | 2022-09-29 |
| JP2021167345A (ja) | 2021-10-21 |
| US10894061B2 (en) | 2021-01-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Branisteanu et al. | Update on the etiopathogenesis of psoriasis | |
| Perrot et al. | TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-γ in response to double-stranded RNA | |
| Nestle et al. | Plasmacytoid predendritic cells initiate psoriasis through interferon-α production | |
| JP7235259B2 (ja) | Gvhd又は腫瘍を治療するための骨髄系由来サプレッサー細胞のインフラマソーム活性化の調節 | |
| Pavlovic et al. | MAIT cells display a specific response to type 1 IFN underlying the adjuvant effect of TLR7/8 ligands | |
| JP2024091728A (ja) | T細胞の拡張及び活性化の方法 | |
| HK40077184A (en) | Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd or tumor | |
| Hsu et al. | The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction | |
| HK1263409B (en) | Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd or tumor | |
| HK1263409A1 (en) | Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd or tumor | |
| HK40100442A (en) | Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd or tumor | |
| HK40023269B (en) | Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd | |
| HK40023269A (en) | Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd | |
| HK1256917B (en) | Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor | |
| Shalova et al. | Monocytes and macrophages | |
| Fu | The Transcriptional Regulation and Function of IL-9 in Allergic Lung Inflammation and Tumor Growth | |
| Alqahtani | Development of autologous macrophage-encapsulated gellan fluid gel for the prevention of blindness from ocular surface scarring | |
| Joachim | Bacterial-Derived Metabolites in the Context of Immune Checkpoint Inhibitor Cancer Therapy | |
| Minns | Innate modifiers of T cell behaviour during inflammatory disease | |
| Martini | Compartmentalisation of the immune response in human skin: cross-talk between dendritic cells and T cells in healthy conditions and in psoriasis | |
| Park YongMean et al. | Eosinophil survival and apoptosis in health and disease. | |
| Haridas | Effect of EMAPII on dendritic cells | |
| Yamaoka et al. | WS/PP-024b-11 Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpG-oligodeoxynucleotide for type-I interferon induction via targeting to static early endosome Y. Tamura, K. Saito, K. Okuya, T. Torigoe, N. Sato. Sapporo Medical University School of Medicine, Sapporo, Japan | |
| Weber et al. | The purinergic receptor P2X7 is a crucial inducer of inflammation in contact hypersensitivity: P104 (V08) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1263409 Country of ref document: HK |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |