CN108853388A - A kind of preparation of composition and treatment and/or the senile pigment wart of nursing - Google Patents

A kind of preparation of composition and treatment and/or the senile pigment wart of nursing Download PDF

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CN108853388A
CN108853388A CN201810914260.8A CN201810914260A CN108853388A CN 108853388 A CN108853388 A CN 108853388A CN 201810914260 A CN201810914260 A CN 201810914260A CN 108853388 A CN108853388 A CN 108853388A
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extract
wart
composition
acid
nursing
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李乾
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Cause Color Biotechnology (wuhan) Co Ltd
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Cause Color Biotechnology (wuhan) Co Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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Abstract

The present invention discloses the preparation of a kind of composition and treatment and/or the senile pigment wart of nursing, wherein, the composition includes Rhizoma Bolbostematis extract, Semen Coicis extract, Herba Equiseti Hiemalis extract, folium eucalypti extract, podophyllum ester, oleic acid, octyl salicylic acid, sodium sulfite, vitamin A acid and resveratrol.In technical solution provided by the invention, the Rhizoma Bolbostematis extract, Semen Coicis extract, Herba Equiseti Hiemalis extract, folium eucalypti extract and podophyllum ester in the composition are pure natural plant extract, have the characteristics that sore is treated in detoxicating and resolving a mass, expelling pathogenic factors from muscles and skin foster skin, clearing damp, suitable for treating and/or nursing senile pigment wart, with good curative effect, and have no toxic side effect.

Description

A kind of preparation of composition and treatment and/or the senile pigment wart of nursing
Technical field
The present invention relates to the technical field of biological medicine, in particular to a kind of composition and treatment and/or nursing are old The preparation of property pigment wart.
Background technique
Senile pigment wart (spot), also known as senile wart, senile pigment wart, senile plaque, basal cell papilloma etc., It is a kind of most common benign skin tumour of clinic, belongs to epidermis benign proliferative diseases caused by keratinocyte hyperplasia, It is medically also known as seborrheic keratosis, symptom is to occur a kind of dark brown pigment patch, slightly above skin in old application on human skin Skin, rough surface can strip off.Senile pigment wart generally often has in face, forehead, back, neck, front etc., sometimes The exsertion parts such as the back of the hand, upper limb may also be appeared in.Major part is to start discovery after 50 years old to increase, and it is old to be more common in advanced age People.
The pathomechanism that senile pigment wart (spot) is formed is not yet clear, therefore treats also without specific medicament.At present Think that the pigment wart of the elderly may be related with peroxide, it is also possible to it is related with immunity degeneration, when general immunity decline, The resistance of skin also and then reduces；The infection of human papilloma virus (HPV) certain hypotypes may be senile pigment wart Reason.There are more than 100 kinds of hypotypes due to being currently known human papilloma virus (HPV), part high-risk-type is reported that itself and uterine neck Cancer morbidity is related, and many other skin benign epidermic hyperplastic tumours (wart or precancerous lesion) are all relevant with HPV, but specific HPV hypotype is not fully clear.
Recent international scientific literature report, with age, the encoding gene of immune system is carrying out mutation to the mankind Accumulation, this explains the elderly's pigment warts, the very high reason of verruca plana disease incidence.However, this skin disease of the elderly Change is usually covered by convention, referred to as " senile plaque ", " senile plaque ", " elderly person for whom a birthday celebration is being held's spot ", " long senile plaque ", so that the elderly oneself passes through Often ignore, hardly go to see a doctor, Research Literature medically is also fewer and fewer.
With the improvement of the living condition of Chinese, the average life span of compatriots increases quickly, and social aging is more and more Obviously, the aged is continuously increased, and the cultural quality of the elderly is also continuously improved, to treating or alleviate senile pigment wart (spot) Demand increase sharply, first is that worrying that the canceration of skin hyperplasia of prostate at cutaneum carcinoma, second is that improving image appearance, improves the old popular feeling Reason is self-confident and makes mental age rejuvenation, further promotes long-lived.Therefore, it is badly in need of at present a kind of significant in efficacy for treating And/or the composition or preparation of the senile pigment wart (spot) of nursing.
Summary of the invention
The main object of the present invention is the preparation for proposing a kind of composition and treatment and/or the senile pigment wart of nursing, Aim to solve the problem that the compound therapeutic effect for being currently used for treating senile pigment wart is bad and there are problems that toxic side effect.
To achieve the above object, the present invention proposes that a kind of composition, the composition include Rhizoma Bolbostematis extract, semen coicis Extract, Herba Equiseti Hiemalis extract, folium eucalypti extract, podophyllum ester, oleic acid, octyl salicylic acid, sodium sulfite, vitamin A acid with And resveratrol.
Preferably, the composition includes the component of following mass fraction：0.1~5 part of Rhizoma Bolbostematis extract, semen coicis mention Take 0.1~3 part of object, 0.1~5 part of Herba Equiseti Hiemalis extract, 0.1~5 part of folium eucalypti extract, 0.1~3 part of podophyllum ester, oleic acid 0.1 ~5 parts, 0.1~6 part of octyl salicylic acid, 0.1~3 part of sodium sulfite, 0.01~3 part of vitamin A acid and resveratrol 0.1~ 5 parts.
Preferably, the composition includes the component of following mass fraction：0.5~3 part of Rhizoma Bolbostematis extract, semen coicis mention Take 0.3~2.5 part of object, 0.5~3 part of Herba Equiseti Hiemalis extract, 0.5~3 part of folium eucalypti extract, 0.3~2 part of podophyllum ester, oleic acid 0.3~3 part, 0.5~5 part of octyl salicylic acid, 0.3~2 part of sodium sulfite, 0.03~2 part of vitamin A acid and resveratrol 0.5~3 part.
Preferably, the composition includes the component of following mass fraction：2 parts of Rhizoma Bolbostematis extract, Semen Coicis extract 1.5 parts, 1 part of Herba Equiseti Hiemalis extract, 1 part of folium eucalypti extract, 0.6 part of podophyllum ester, 0.6 part of oleic acid, 3 parts of octyl salicylic acid, Asia 1 part of sodium sulphate, 0.06 part of vitamin A acid and 0.8 part of resveratrol.
The present invention also provides a kind of preparations for treating and/or nursing senile pigment wart, including combine as described above Object.
Preferably, the preparation for treating and/or nursing senile pigment wart is percutaneous drug delivery external preparation.
Preferably, the dosage form of the treatment and/or the preparation for nursing senile pigment wart is emulsion, creme, solution, puts on the skin Agent, lotion or paste.
In technical solution provided by the invention, the Rhizoma Bolbostematis extract, Semen Coicis extract, Herba Equiseti Hiemalis extract, eucalyptus Leaf extract and podophyllum ester are pure natural plant extract, have the characteristics that sore is treated in detoxicating and resolving a mass, expelling pathogenic factors from muscles and skin foster skin, clearing damp, Suitable for treating and/or nursing senile pigment wart, there is good curative effect, and have no toxic side effect.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase Product.
The present invention provides a kind of composition, can be used for treating senile pigment wart, or assist in the treatment of other pathogenesis Illness similar with senile pigment wart.The composition includes Rhizoma Bolbostematis extract, Semen Coicis extract, Equisetum hiemale Linne extraction Object, folium eucalypti extract, podophyllum ester, oleic acid, octyl salicylic acid, sodium sulfite, vitamin A acid and resveratrol.Wherein：
The Rhizoma Bolbostematis extract is extracted by the drying stem block of the Chinese medicine rhizoma bolbostemmae, the rhizoma bolbostemmae also known as native shellfish, big fritillaria, it is bitter Gallbladder or careless shellfish, have effects that removing toxic substances, dissipating bind, detumescence.Separately also there is modern biology the study found that the rhizoma bolbostemmae has suppression The effect of making the infection of certain HPV viruses.
The Semen Coicis extract is extracted by the dry fruit of Chinese medicine adlay, and the semen coicis is gramineae Dry mature kernal has clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, the effect of detoxicating and resolving a mass.Separately also there is modern biology The study found that the semen coicis has effects that inhibit certain HPV viruse infection.
The Herba Equiseti Hiemalis extract, is the dry aerial parts extract of Equisetaceae plant scouring rush, and the Equisetum hiemale Linne is extracted Object energy sweating, expelling pathogenic factors from muscles and skin move back screen, and flat sore is swollen hard.Separately also there is modern folk remedy to prompt, the Equisetum hiemale Linne, which has, inhibits certain creams The effect of head tumor.
The folium eucalypti extract is the full leaf extract of myrtle eucalyptus.The eucalyptus has tourette production of aromatic, removes It is smelly disinfection, clearing damp heresy effect.Separately also there is modern biology the study found that the folium eucalypti has broad-spectrum antibacterial and anti-corrosion effect.
The podophyllum ester is the extract of sufficient leaf grass or Chinese podophyllum root, according to modern biology the study found that the foot leaf grass Ester has certain relaxation effect to condyloma acuminatum, wherein the condyloma acuminatum is by a few HPV infection.
The oleic acid is a kind of straight chain list unsaturation Omega-9 fatty acid, is formed in the bodies of aminal and plant that there are many industry Purposes.The oleic acid is also indispensable nutrient in animal food；The acidity of the oleic acid can promote cuticulated epithelium soft Change, liposoluble substance is promoted to absorb, moisture of skin is prevented to evaporate, protects cuticula to alleviate oxidative damage.
The octyl salicylic acid is salicylic octyl derivative, has effects that cutin-softening promotes Drug Percutaneous Absorption, To reinforce the effect of the oleic acid.
The effect of vitamin A acid has and promotes epithelial growth metabolism, and the normal angling of maintenance epithelium is broken up.
The sodium sulfite, with anti-oxidant and bleaching industrial use, in addition, the sodium sulfite is also daily use chemicals license Additive.
The resveratrol has strength antioxidant effect, can eliminate oxidative damage caused by free radical, has protection The effect of cell.
It should be noted that the oleic acid, octyl salicylic acid, sodium sulfite, vitamin A acid and resveratrol are existing Product can directly purchase acquisition in the market；The Rhizoma Bolbostematis extract, Semen Coicis extract, Herba Equiseti Hiemalis extract, folium eucalypti mention It takes object and podophyllum ester equally also for existing product, can directly purchase acquisition in the market, or can also be by from described Correspondence prepares in the plants such as the rhizoma bolbostemmae, semen coicis, Equisetum hiemale Linne, folium eucalypti and sufficient leaf grass, and specific preparation method can refer to The prior art is not described further herein.
In technical solution provided by the invention, the Rhizoma Bolbostematis extract, Semen Coicis extract, Herba Equiseti Hiemalis extract, eucalyptus Leaf extract and podophyllum ester are pure natural plant extract, have the characteristics that sore is treated in detoxicating and resolving a mass, expelling pathogenic factors from muscles and skin foster skin, clearing damp, Suitable for treating and/or nursing senile pigment wart, there is good curative effect, and have no toxic side effect.
Preferably, in the present embodiment, the composition includes the component of following mass fraction：Rhizoma Bolbostematis extract 0.1 ~5 parts, 0.1~3 part of Semen Coicis extract, 0.1~5 part of Herba Equiseti Hiemalis extract, 0.1~5 part of folium eucalypti extract, podophyllum ester 0.1~3 part, 0.1~5 part of oleic acid, 0.1~6 part of octyl salicylic acid, 0.1~3 part of sodium sulfite, 0.01~3 part of vitamin A acid And 0.1~5 part of resveratrol.
Further, as a preferred embodiment of the invention, the composition includes the component of following mass fraction： 0.5~3 part of Rhizoma Bolbostematis extract, 0.3~2.5 part of Semen Coicis extract, 0.5~3 part of Herba Equiseti Hiemalis extract, folium eucalypti extract 0.5~3 part, 0.3~2 part of podophyllum ester, 0.3~3 part of oleic acid, 0.5~5 part of octyl salicylic acid, 0.3~2 part of sodium sulfite, dimension Raw 0.03~2 part and 0.5~3 part of resveratrol of element A acid.
Further, as presently most preferred embodiment of the invention, the composition includes the group of following mass fraction Point：2 parts of Rhizoma Bolbostematis extract, 1.5 parts of Semen Coicis extract, 1 part of Herba Equiseti Hiemalis extract, 1 part of folium eucalypti extract, podophyllum ester 0.6 part, 0.6 part of oleic acid, 3 parts of octyl salicylic acid, 1 part of sodium sulfite, 0.06 part of vitamin A acid and 0.8 part of resveratrol.
The present invention also provides a kind of preparations for treating and/or nursing senile pigment wart, can be used for treating senile pigment Wart is to alleviate inflammation or the senile pigment wart of nursing to prevent patch appearance, or has both the function for the treatment of and nursing, effectively Multiple clinical stages suitable for senile pigment wart.Wherein, the preparation for treating and/or nursing senile pigment wart includes Composition as described above.The treatment and/or to nurse the preparation of senile pigment wart further include Material, for example, be controlled when described When treating and/or nurse the preparation of senile pigment wart and being specially externally-applied ointment, the Material is externally-applied ointment Material, when described When the preparation for treating and/or nursing senile pigment wart is face cream, the Material is face cream Material.It needs to illustrate It is that the preparation of the Material can be found in the prior art, does not repeat herein.It is existing that the composition can be used as additive addition In the Material, the treatment is made and/or nurses the preparation of senile pigment wart, makes to have and treat senile pigment wart effect Fruit is good and the advantages of having no toxic side effect.Similarly, the treatment and/or the specific preparation for the preparation for nursing senile pigment wart Method can refer to the technological means of the existing additive that other treatment function is added for example in ordinary preparation, not go to live in the household of one's in-laws on getting married herein It states.
The treatment and/or the preparation for nursing senile pigment wart can be diversified forms, but due to the senile color Plain wart belongs to epidermis benign proliferative diseases, namely is obvious from skin appearance skin, it is therefore preferred that the treatment and/or nursing The preparation of senile pigment wart is percutaneous drug delivery external preparation, be can be used for coated on affected part to be treated and/or be nursed.
Further, in the present embodiment, the dosage form of the treatment and/or the preparation for nursing senile pigment wart is preferably Emulsion, creme, solution, liniment, lotion or paste.That is, the preparation treated and/or nurse senile pigment wart The form of expression can be specifically as follows the skin care milk etc. of the corresponding emulsion dosage form to be a variety of, by taking daily nursing class product as an example； Correspond to the Essence of the solution dosage form, paste type facial mask etc.；Cold cream, the application type facial mask of the corresponding paste dosage form Deng.The treatment and/or the preparation for nursing senile pigment wart can also be with the emulsion, creme, solution, liniment, wash The topical agent that agent or ointment use.It should be noted that the preparation for treating and/or nursing senile pigment wart Dosage form can also be not limited to above-mentioned dosage form, but be added with the composition, convenient for users to routine use, and have aobvious The curative effect of the senile pigment wart write, and have no toxic side effect.
Technical solution of the present invention is described in further detail below in conjunction with specific embodiment, it should be understood that following real It applies example to be only used to explain the present invention, be not intended to limit the present invention.
Embodiment 1
(1) Material of 980g externally-applied ointment is weighed, wherein the Material of the externally-applied ointment includes the component of following quality： Propylene glycol 100g, 2% sodium hydroxide 60g, albolene 90g, atoleine 200g, octadecyl alcolol 50g, glycerin monostearate 50g, propylparaben 0.5g, menthol 5g, methyl p-hydroxybenzoate 0.5g, stearic acid polyene oxygen rouge 30g and Distilled water 394g.
(2) the composition 20g is weighed to mix with the Material of above-mentioned externally-applied ointment, it is outer containing the composition to be made With ointment, wherein the composition includes the component of following quality：Rhizoma Bolbostematis extract 0.1g, Semen Coicis extract 0.1g, wood Crafty grass extract 5.13g, folium eucalypti extract 5.13g, podophyllum ester 3.08g, oleic acid 0.1g, octyl salicylic acid 6.15g, sulfurous acid Sodium 0.1g, vitamin A acid 0.01g and resveratrol 0.1g.
Embodiment 2
(1) Material of 980g externally-applied ointment is weighed, wherein component contained by the Material of the externally-applied ointment and corresponding matter Amount is referring to embodiment 1；
(2) the composition 20g is weighed to mix with the Material of above-mentioned externally-applied ointment, it is outer containing the composition to be made With ointment, wherein the composition includes the component of following quality：Rhizoma Bolbostematis extract 4.1g, Semen Coicis extract 2.46g, Herba Equiseti Hiemalis extract 0.08g, folium eucalypti extract 0.08g, podophyllum ester 0.08g, oleic acid 4.1g, octyl salicylic acid 0.08g, sulfurous Sour sodium 2.46g, vitamin A acid 2.46g and resveratrol 4.1g.
Embodiment 3
(1) Material of 980g externally-applied ointment is weighed, wherein component contained by the Material of the externally-applied ointment and corresponding matter Amount is referring to embodiment 1；
(2) the composition 20g is weighed to mix with the Material of above-mentioned externally-applied ointment, it is outer containing the composition to be made With ointment, wherein the composition includes the component of following quality：Rhizoma Bolbostematis extract 3.46g, Semen Coicis extract 2.6g, Herba Equiseti Hiemalis extract 1.73g, folium eucalypti extract 1.73g, podophyllum ester 1.04g, oleic acid 1.04g, octyl salicylic acid 5.19g, Asia Sodium sulphate 1.73g, vitamin A acid 0.1g and resveratrol 1.38g.
Embodiment 4
(1) Material of 980g externally-applied ointment is weighed, wherein component contained by the Material of the externally-applied ointment and corresponding matter Amount is referring to embodiment 1；
(2) the composition 20g is weighed to mix with the Material of above-mentioned externally-applied ointment, it is outer containing the composition to be made With ointment, wherein the composition includes the component of following quality：Rhizoma Bolbostematis extract 3.55g, Semen Coicis extract 1.42g, Herba Equiseti Hiemalis extract 2.84g, folium eucalypti extract 2.12g, podophyllum ester 1.42g, oleic acid 1.42g, octyl salicylic acid 3.55g, Asia Sodium sulphate 1.13g, vitamin A acid 0.43g and resveratrol 2.12g.
Embodiment 5
(1) Material of 980g externally-applied ointment is weighed, wherein component contained by the Material of the externally-applied ointment and corresponding matter Amount is referring to embodiment 1；
(2) the composition 20g is weighed to mix with the Material of above-mentioned externally-applied ointment, it is outer containing the composition to be made With ointment, wherein the composition includes the component of following quality：Rhizoma Bolbostematis extract 0.68g, Semen Coicis extract 3.42g, Herba Equiseti Hiemalis extract 0.68g, folium eucalypti extract 4.12g, podophyllum ester 0.41g, oleic acid 0.41g, octyl salicylic acid 0.68g, Asia Sodium sulphate 2.74g, vitamin A acid 2.74g and resveratrol 4.12g.
Embodiment 6
(1) Material of 980g externally-applied ointment is weighed, wherein component contained by the Material of the externally-applied ointment and corresponding matter Amount is referring to embodiment 1；
(2) the composition 20g is weighed to mix with the Material of above-mentioned externally-applied ointment, it is outer containing the composition to be made With ointment, wherein the composition includes the component of following quality：Rhizoma Bolbostematis extract 3.4g, Semen Coicis extract 0.34g, Herba Equiseti Hiemalis extract 3.4g, folium eucalypti extract 0.57g, podophyllum ester 2.28g, oleic acid 3.4g, octyl salicylic acid 5.67g, sulfurous Sour sodium 0.34g, vitamin A acid 0.03g and resveratrol 0.57g.
Embodiment 7
(1) Material of 950g face cream is weighed, wherein the Material of the face cream includes the component of following quality：It is stearic Sour 57g, stearyl alcohol 17g plus hydrogen lanolin 35g, saualane 78g, 2- octyldodecanol 86g, 1,3-BDO 52g, poly- second Glycol 1500 35g, POE (25) spermaceti alcohol ether 26g, glycerin monostearate 17g, preservative 3g, antioxidant 43g, fragrance 35g and Purified Water 466g.
(2) it weighs the composition 50g to mix with the Material of above-mentioned face cream, the skin care containing the composition is made Frost, wherein the composition includes the component of following quality：Rhizoma Bolbostematis extract 8.64g, Semen Coicis extract 6.48g, scouring rush Careless extract 4.33g, folium eucalypti extract 4.33g, podophyllum ester 2.6g, oleic acid 2.6g, octyl salicylic acid 12.97g, sodium sulfite 4.33g, vitamin A acid 0.26g and resveratrol 3.46g.
Embodiment 8
(1) Material of 950g facial treatment milk is weighed, wherein the Material of the facial treatment milk includes the component of following quality： Albolene 86g, octadecyl alcolol 52g, ethylparaben 4g, glycerin monostearate 104g, silicone oil 173g, glycerol 242g, sulfurous Sour hydrogen sodium 4g, atoleine 120g, sericin 17g and distilled water 148g.
(2) it weighs the composition 50g to mix with the Material of above-mentioned facial treatment milk, the shield containing the composition is made Skin lotion, wherein the composition includes the component of following quality：Rhizoma Bolbostematis extract 8.64g, Semen Coicis extract 6.48g, Herba Equiseti Hiemalis extract 4.33g, folium eucalypti extract 4.33g, podophyllum ester 2.6g, oleic acid 2.6g, octyl salicylic acid 12.97g, sulfurous Sour sodium 4.33g, vitamin A acid 0.26g and resveratrol 3.46g.
Embodiment 9
(1) Material of 950g facial treatment essence liquid is weighed, wherein the Material of the facial treatment essence liquid includes the group of following quality Point：Lily polysaccharide 75g, butanediol 110g, cinnamic acid 25g, isopropyl myristate 30g, silicone oil 30g, Sodium Hyaluronate 15g, Trehalose 25g, antierythrite 20g, xanthan gum 50g, emulsifier 30g, octadecyl alcolol 40g, monoglyceride 30 and deionized water 470g。
(2) it weighs the composition 50g to mix with the Material of above-mentioned facial treatment essence liquid, to be made containing the composition Facial treatment essence liquid, wherein the composition includes the component of following quality：Rhizoma Bolbostematis extract 8.64g, Semen Coicis extract 6.48g, Herba Equiseti Hiemalis extract 4.33g, folium eucalypti extract 4.33g, podophyllum ester 2.6g, oleic acid 2.6g, octyl salicylic acid 12.97g, sodium sulfite 4.33g, vitamin A acid 0.26g and resveratrol 3.46g.
Embodiment 10
(1) 600g medical ethanol is weighed, wherein the mass concentration of the ethyl alcohol is 95%.
(2) it weighs the composition 400g to compound with the alcohol, the tincture containing the composition is made, wherein The composition includes the component of following quality：Rhizoma Bolbostematis extract 87.34g, Semen Coicis extract 65.5g, Equisetum hiemale Linne are extracted Object 43.67g, folium eucalypti extract 43.67g, podophyllum ester 26.2g, oleic acid 26.2g, octyl salicylic acid 26.2g, sodium sulfite 43.67g, vitamin A acid 2.62g and resveratrol 34.93g.
Embodiment 11
(1) matrix of 980g lotion is weighed, wherein the matrix of the lotion includes the component of following quality：Alum 4g, AES (70%) 52g, DS-600 3g, MES 32g, lanolin 4g, imidazoline 80g, Ninol 22g, GW-901 15g, essence 1g, preservative 1g and deionized water 766g.
(2) the composition 20g is weighed to mix with the matrix of above-mentioned lotion, the lotion containing the composition is made, Wherein, the composition includes the component of following quality：Rhizoma Bolbostematis extract 3.46g, Semen Coicis extract 2.6g, Equisetum hiemale Linne mention Take object 1.73g, folium eucalypti extract 1.73g, podophyllum ester 1.04g, oleic acid 1.04g, octyl salicylic acid 5.19g, sodium sulfite 1.73g, vitamin A acid 0.1g and resveratrol 1.38g.
By taking the externally-applied ointment containing the Chinese medicine composition prepared by above-described embodiment 3 as an example, to treatment provided by the invention The curative effect of the senile pigment wart of the preparation for treating of senile pigment wart is verified, the treatment including clinical case and typical case Clinical trial, test method and result are as follows：
1, clinical case
(1) case selection：Senile pigment wart patient 100 made a definite diagnosis are selected, wherein male patient 50, female patient 50, the age, the qualification of all patients was almost the same between 40~80 years old, and no significant difference is comparable.
(2) diagnostic criteria：Senile pigment wart is generally mainly in after 40 years old；It is apt to occur in the face of the elderly, the back of the hand, small Usually on the exposed skin such as leg, instep, trunk；Patch is in brown-black, and patch diameter is generally between 1~10mm, it is also possible to Reach between 2~3cm；For patch majority not above skin surface, a small number of big spots may also be above skin surface, in flat Shape；General no conscious sympton occasionally has itch sense of discomfort.
(3) treatment method：When clinical application, daily coating on daytime affected part 3 times, every minor tick 4 hours, after continuing 3 months, Count clinical efficacy.
(4) efficacy determination：Specific curative effect determinate standard please refers to shown in table 1.
The senile pigment wart efficacy evaluation method of table 1
Curative effect Clinical symptoms
Recovery from illness Macroscopic plaque area fading is greater than 90%, and color disappears substantially
It is effective Macroscopic plaque area fading is greater than 60%, and color is obviously thin out
Effectively Macroscopic plaque area fading is greater than 30%, and color is visually thin out
In vain Macroscopic plaque area fading is less than 10%, and color is without significant change
(5) treatment results：Specific efficacy result please refers to shown in table 2.
The curative effect statistical result of the senile pigment wart patient of table 2
Effective number (example) Significant figure (example) Invalid number (example) Obvious effective rate (%) Efficient (%)
Patient 72 20 8 72 92
By the statistical result in table 2 it is found that the curative effect of the preparation of the senile pigment wart for the treatment of of preparation of the embodiment of the present invention Significantly, and have no toxic side effect, follow-up is without recurrence.
2, typical case
Case one：Lee, male, 73 years old, Symptoms：There is uneven spot in neck, the back of the hand and back, and big spot is high Skin out is in flat, brown color.Diagnosis：Belong to typical senile pigment wart.By this implementation of coating during treatment Externally-applied ointment described in example 3,3 times a day, after 3 months, clinical observation finds macroscopic plaque area fading about 70%, color It is obvious thin out in light brown.
Case two：Tang, female, 46 years old, Symptoms：At facial two cheeks, forehead, front and the back of the hand there is spot, spot Point is brown, and biennium spot persistently increases.Diagnosis：Belong to typical senile pigment wart.By this reality of coating during treatment Externally-applied ointment described in example 3 is applied, 3 times a day, after 1 month, clinical observation finds that macroscopic plaque area fading, color are obvious It is thin out；After 3 months, clinical observation finds macroscopic plaque area fading about 90%, and color disappears substantially.
In conclusion the preparation of the senile pigment wart for the treatment of provided by the invention, is extracted with Rhizoma Bolbostematis extract, semen coicis Object, Herba Equiseti Hiemalis extract, folium eucalypti extract, podophyllum ester, oleic acid, octyl salicylic acid, sodium sulfite, vitamin A acid and white Veratryl alcohol prepares for raw material, significant to the therapeutic effect of senile pigment wart, can be taken effect using one month, lasting to use Effect is obvious, can effective fading senile pigment wart, have no toxic side effect and adverse reaction, and low in cost, be easy to by patient Receive.
The above is only a preferred embodiment of the present invention, is not intended to limit the scope of the invention, for this field For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any Modification, equivalent replacement, improvement etc. should all be included within the scope of the present invention.

Claims (7)

1. a kind of composition, which is characterized in that the composition includes that Rhizoma Bolbostematis extract, Semen Coicis extract, Equisetum hiemale Linne mention Take object, folium eucalypti extract, podophyllum ester, oleic acid, octyl salicylic acid, sodium sulfite, vitamin A acid and resveratrol.
2. composition as described in claim 1, which is characterized in that the composition includes the component of following mass fraction：Soil 0.1~5 part of fritillaria extract, 0.1~3 part of Semen Coicis extract, 0.1~5 part of Herba Equiseti Hiemalis extract, folium eucalypti extract 0.1~5 Part, 0.1~3 part of podophyllum ester, 0.1~5 part of oleic acid, 0.1~6 part of octyl salicylic acid, 0.1~3 part of sodium sulfite, vitamin A 0.01~3 part and 0.1~5 part of resveratrol of acid.
3. composition as claimed in claim 2, which is characterized in that the composition includes the component of following mass fraction：Soil 0.5~3 part of fritillaria extract, 0.3~2.5 part of Semen Coicis extract, 0.5~3 part of Herba Equiseti Hiemalis extract, folium eucalypti extract 0.5 ~3 parts, 0.3~2 part of podophyllum ester, 0.3~3 part of oleic acid, 0.5~5 part of octyl salicylic acid, 0.3~2 part of sodium sulfite, dimension life 0.03~2 part of plain A acid and 0.5~3 part of resveratrol.
4. composition as claimed in claim 3, which is characterized in that the composition includes the component of following mass fraction：Soil 2 parts of fritillaria extract, 1.5 parts of Semen Coicis extract, 1 part of Herba Equiseti Hiemalis extract, 1 part of folium eucalypti extract, 0.6 part of podophyllum ester, 0.6 part of oleic acid, 3 parts of octyl salicylic acid, 1 part of sodium sulfite, 0.06 part of vitamin A acid and 0.8 part of resveratrol.
5. a kind for the treatment of and/or the preparation for nursing senile pigment wart, which is characterized in that including such as 1 to 4 any one institute of right The composition stated.
6. treating and/or nursing as claimed in claim 5 the preparation of senile pigment wart, which is characterized in that the treatment and/ Or the preparation of the senile pigment wart of nursing is percutaneous drug delivery external preparation.
7. treating and/or nursing as claimed in claim 5 the preparation of senile pigment wart, which is characterized in that the treatment and/ Or the dosage form of the preparation of the senile pigment wart of nursing is emulsion, creme, solution, liniment, lotion or paste.
CN201810914260.8A 2018-08-10 2018-08-10 A kind of preparation of composition and treatment and/or the senile pigment wart of nursing Pending CN108853388A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1258530A (en) * 1998-12-31 2000-07-05 甘肃省医学科学研究院 Liniment for treating skin wart, infectious soft wart and senile wart

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1258530A (en) * 1998-12-31 2000-07-05 甘肃省医学科学研究院 Liniment for treating skin wart, infectious soft wart and senile wart

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
徐文峰等: "《常见病自我诊疗》", 31 May 2003, 广州出版社 *
马振友等: "《皮肤美容化妆品制剂手册》", 31 January 2015, 中医古籍出版社 *

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Application publication date: 20181123