CN108853296A - A kind of rhizoma pinellinae praeparata processing procedure and products thereof and application - Google Patents
A kind of rhizoma pinellinae praeparata processing procedure and products thereof and application Download PDFInfo
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Abstract
The invention discloses a kind of rhizoma pinellinae praeparata processing procedure and products thereof and application, rhizoma pinellinae praeparata processing procedure include the steps that slice, configuration Radix Glycyrrhizae lime liquor the step of, rotary heat-insulating pressure maintaining impregnate the step of, drying step to get rhizoma pinellinae praeparata medicine materical crude slice.Rhizoma pinellinae praeparata processing procedure of the invention, on the one hand exists《Pharmacopeia》Under the guidance of preparation method, optimize rhizoma pinellinae praeparata production process, using directly Radix Glycyrrhizae lime liquor being added to impregnate, change and first impregnate the traditional method that the heart uses Radix Glycyrrhizae limewash to impregnate again with drinking water, impregnates technology in conjunction with rotary heat-insulating pressure maintaining, by 10 days original concocted times, 1.2-2 days, greatly shortening concocted time are foreshortened to, and reduce the loss of effective component, product appearance and inherent quality are promoted, and ensure that the stability and reproducibility of kind technique.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation technologies more particularly to a kind of rhizoma pinellinae praeparata processing procedure and products thereof and application.
Background technique
The tuber of pinellia is the dry tuber of Araeceae tuber of pinellia Pinellia ternata (Thunb.) Breit..Yu Xia, autumn two
Season cauline leaf it is luxuriant when excavate, remove crust and fibrous root, dry or dry, as dried pinellia.The dry tuber of the tuber of pinellia is rounded,
Semicircle spherical shape or deflection shape, diameter 0.6-1.5cm；There are the stem trace of recess, the densely covered dotted trace of point of surrounding in top；It is blunt below
Circle is more smooth.Tuber of pinellia gas is micro-, hides pungent, numb tongue and pierces larynx；It is pungent, warm, toxic, returns spleen, stomach, lung channel.Primary efficacy and effect
It is:It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；For phlegm and headache, vomiting gastric disorder causing nausea, cough and phlegm, phlegm retention anti-dazzle nervous, wind phlegm is dizzy
Dizzy, chest Anhui ruffian is bored, globus hysteriocus, controlling outward carbuncle swells subcutaneous nodule.The tuber of pinellia is toxic, eats 0.1-1.8g raw, can cause to be poisoned：To oral cavity, larynx
Head, gastrointestinal mucosal can cause intense stimulus；Clothes can make dispute numb on a small quantity, take volume then and will appear Burning Pain swelling, cannot
Sounding, vomiting, total numbness, oligopnea are finally benumbed and dead without symptoms such as whole, spasm, expiratory dyspnea；It is more to take dried pinellia
Amount can lead to permanent aphonia.
It because Toxicity of Rhizoma Pinelliae is larger, need to be used after processing, be divided into rhizoma pinellinae praeparata, prepared RHIZOMA PINELLIZE without adju-vant, pinellia according to concocting method difference
Deng.《Chinese Pharmacopoeia》The preparation method that rhizoma pinellinae praeparata is recorded in 2015 editions is as follows：The tuber of pinellia is taken, size is separated, it is soaked in water to interior without the dry heart,
It at least impregnates 2-3 days, takes out；Another extracting liquorice is appropriate, adds water to cook secondary, and collecting decoction pours into the lime made of suitable quantity of water
It in liquid, stirs evenly, the above-mentioned tuber of pinellia being impregnated with is added, impregnate, daily stirring 1-2 times, and 12 or more immersion liquid pH value is kept, impregnate 7-
8 days, until section yellow homogeneous, mouth taste it is micro- taken out when having numb feeling in the tongue, clean, (or slice) dries in the shade or dry.According to《Middle traditional Chinese medicines
Allusion quotation》Concocting method processing rhizoma pinellinae praeparata at least need 10 days, the production cycle is long, and production efficiency is low, is influenced by weather temperature, labor
Fatigue resistance is big.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of rhizoma pinellinae praeparata processing procedures.It should
Processing procedure overcomes concocted time length, quality in traditional handicraft and is difficult to control and is not easy the defect promoted and applied, provides
It is a kind of to process short period, simple process, system easy to control the quality and the rhizoma pinellinae praeparata preparation process for being easy to application.
The second object of the present invention is to provide a kind of rhizoma pinellinae praeparata medicine materical crude slice, and the rhizoma pinellinae praeparata medicine materical crude slice is according to above-mentioned processing procedure
It is made.
The third object of the present invention be to provide as described above Pinellia ternata decoction pieces preparation for treat abundant expectoration cough and asthma,
Application in the pharmaceutical composition of phlegm retention anti-dazzle nervous, anemophlegmatic vertigo or phlegm and headache.
An object of the present invention adopts the following technical scheme that realization：A kind of rhizoma pinellinae praeparata processing procedure, includes the following steps：
The step of slice：The tuber of pinellia is cut into tuber of pinellia thin slice；
The step of configuring Radix Glycyrrhizae lime liquor：Extracting liquorice piece is placed in extractor, and water is added and carries out first time decoction, decoction liquor
Filtering, separating filtrate and filter residue；Filter residue is added water and carries out second of decoction, and filtering merges filtrate twice；In resulting filtrate
Quick lime is added, pH value keeps 12 or more, stirs evenly, obtain Radix Glycyrrhizae lime liquor；
The step of rotary heat-insulating pressure maintaining is impregnated：Tuber of pinellia thin slice is directly added into Radix Glycyrrhizae lime liquor, rotary heat-insulating is placed in
Immersion 24-36h is carried out in pressure maintaining steeping tank, is taken out；
Dry step：Tuber of pinellia thin slice after immersion is put in a drying box to be dried using gradient heating, i.e.,
It does in the proper way Pinellia ternata decoction pieces.
Further, slice the step of in, the tuber of pinellia thin slice with a thickness of 1.5-2.5mm.
Further, in the step of configuring Radix Glycyrrhizae lime liquor, the Radix Glycyrrhizae is the 18-22% of tuber of pinellia flake weight；Institute
State the 7-10% that quick lime is tuber of pinellia flake weight.
Further, in the step of configuring Radix Glycyrrhizae lime liquor, amount of water when decocting for the first time is Radix Glycyrrhizae sheet weight
It 6-8 times, decocts temperature and is maintained at 75-85 DEG C, decocting time 1-2h；Amount of water when second of decoction is Radix Glycyrrhizae sheet weight
It 4-6 times, decocts temperature and is maintained at 80-85 DEG C, decocting time 0.5-1h.
Further, in the step of rotary heat-insulating pressure maintaining is impregnated, the pressure in the rotary heat-insulating pressure maintaining steeping tank is protected
It holds in 0.3-0.45MPa, temperature is maintained at 55-65 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation one
Secondary, each rotary heat-insulating pressure maintaining steeping tank is to rotate 10-15min, rotation speed 10- along clockwise, counterclockwise each
15r/min。
Further, the pressure when the tuber of pinellia thin slice is with a thickness of 1.5mm, in the rotary heat-insulating pressure maintaining steeping tank
It is maintained at 0.3MPa, temperature is maintained at 55 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, every time
Rotary heat-insulating pressure maintaining steeping tank is to rotate 10min, rotation speed 10r/min along clockwise, counterclockwise each；It is rotating
It is impregnated for 24 hours in heat-insulation pressure keeping steeping tank；
When the tuber of pinellia thin slice is with a thickness of 2mm, the pressure in the rotary heat-insulating pressure maintaining steeping tank is maintained at
0.4MPa, temperature are maintained at 58 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and rotation is protected every time
Warm pressure maintaining steeping tank is to rotate 12min, rotation speed 12r/min along clockwise, counterclockwise each；It is protected in rotary heat-insulating
Immersion 28h is carried out in pressure steeping tank；
When the tuber of pinellia thin slice is with a thickness of 2.5mm, the pressure in the rotary heat-insulating pressure maintaining steeping tank is maintained at
0.45MPa, temperature are maintained at 65 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and rotation is protected every time
Warm pressure maintaining steeping tank is to rotate 15min, rotation speed 15r/min along clockwise, counterclockwise each；It is protected in rotary heat-insulating
Immersion 36h is carried out in pressure steeping tank.
Further, in dry step, the condition for using gradient heating is 50 DEG C for initial temperature, is kept
2-3h；0.5 DEG C/5min is warming up to 70 DEG C, then keeps 3-4h.
The second object of the present invention adopts the following technical scheme that realization：A kind of rhizoma pinellinae praeparata medicine materical crude slice, the rhizoma pinellinae praeparata medicine materical crude slice according to
The processing procedure is made.
The third object of the present invention adopts the following technical scheme that realization：Rhizoma pinellinae praeparata medicine materical crude slice is used in preparation as described above
Application in the pharmaceutical composition for the treatment of abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo or phlegm and headache.
Compared with prior art, the beneficial effects of the present invention are：
(1) rhizoma pinellinae praeparata processing procedure of the invention, on the one hand exists《Pharmacopeia》Under the guidance of preparation method, rhizoma pinellinae praeparata production is optimized
Technical process, using directly Radix Glycyrrhizae lime liquor being added to impregnate, change first impregnates the heart with drinking water and Radix Glycyrrhizae limewash is used to impregnate again
Traditional method impregnates technology in conjunction with rotary heat-insulating pressure maintaining and is foreshortened to 1.2-2 days by 10 days original concocted times, greatly shortened
Concocted time, and reduce the loss of effective component, product appearance and inherent quality are promoted, ensure that the stability of kind technique with
Reproducibility.
(2) on the other hand, mechanical treatment is carried out using extractor, rotary heat-insulating pressure maintaining steeping tank, instead of manual operation
It easily leads to and impregnates non-uniform problem, improve the uniformity of immersion, be truly realized the effect of attenuation synergistic, ensure that rhizoma pinellinae praeparata
Quality, meet the requirement of drug user.
(3) simple process, it is easy to operate, it is suitble to large-scale industrial production.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
In the present invention, if not refering in particular to, all parts, percentage are unit of weight, used equipment and raw material etc.
It is commercially available or commonly used in the art.Method in following embodiments is unless otherwise instructed the normal of this field
Rule method.
A kind of rhizoma pinellinae praeparata processing procedure, includes the following steps：
The step of slice：The tuber of pinellia is cut into the tuber of pinellia thin slice with a thickness of 1.5-2.5mm；The present invention is by shave, directly
It impregnates, can greatly shorten the soaking time of the tuber of pinellia, avoid the loss of tuber of pinellia effective component in immersion, due to having for the tuber of pinellia
Effect ingredient is alkaloid, and alkaloid is easily soluble in water, therefore when first being impregnated according to conventional method, can also be led in soaking process
The part of alkaloid effective component is caused to be lost, therefore the application changes the mode of immersion, Radix Glycyrrhizae stone of the direct slicing in alkalinity
It is impregnated in lixivium, since alkaloid not readily dissolves in alkaline solution, the also loss of effective protection medicinal ingredient.
The step of configuring Radix Glycyrrhizae lime liquor：It takes the licorice tablet of tuber of pinellia flake weight 18-22% to be placed in extractor, is added sweet
The water that 6-8 times of blade weight is measured carries out first time decoction, decocts temperature and is maintained at 75-85 DEG C, decocting time 1-2h, decocts
Liquid filtering, separating filtrate and filter residue；The 4-6 times of water measured that Radix Glycyrrhizae sheet weight is added in filter residue carries out second and decocts, and decocts temperature
It is maintained at 80-85 DEG C, decocting time 0.5-1h, filtering merges filtrate twice；Tuber of pinellia thin slice weight is added in resulting filtrate
The quick lime of 7-10% is measured, pH value keeps 12 or more, stirs evenly, obtain Radix Glycyrrhizae lime liquor；Using the Radix Glycyrrhizae lime of suitable concentration
Liquid impregnates the tuber of pinellia, and one side Radix Glycyrrhizae lime liquor penetrates into inside the tuber of pinellia, improves detoxification effect and on the other hand under alkaline condition, keeps away
Exempt from the loss of tuber of pinellia effective component.
The step of rotary heat-insulating pressure maintaining is impregnated：Tuber of pinellia thin slice is directly added into Radix Glycyrrhizae lime liquor, rotary heat-insulating is placed in
Immersion 24-36h is carried out in pressure maintaining steeping tank, the pressure in rotary heat-insulating pressure maintaining steeping tank is maintained at 0.3-0.45MPa, and temperature is protected
It holds at 55-65 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and each rotary heat-insulating pressure maintaining is impregnated
Tank is to rotate 10-15min, rotation speed 10-15r/min along clockwise, counterclockwise each；It takes out；In this step,
Purpose using heat preservation, pressure maintaining, immersion, rotation is that Radix Glycyrrhizae lime liquor is accelerated to penetrate into inside tuber of pinellia thin slice, so as to shorten processing
Period.
Dry step：Tuber of pinellia thin slice after immersion is put in a drying box to be dried using gradient heating, is adopted
Be initial temperature with the condition of gradient heating it is 50 DEG C, keeps 2-3h；0.5 DEG C/5min is warming up to 70 DEG C, then keeps 3-
4h is to get rhizoma pinellinae praeparata medicine materical crude slice.Use gradient increased temperature in dry link, make material by it is outer and in be gradually heated, ensure that dry equal
Evenness and product appearance character, avoid color difference and " keratinization ".
This law changes the way that traditional rhizoma pinellinae praeparata is first soaked with clear water, because the processing detoxification of the tuber of pinellia depends on auxiliary material
Effect, toxic component is not readily dissolved in water, and effective component is easy to be lost during clear water impregnates, and in summer high temperature
Shi Qingshui immersion is easy to appear rancid phenomenon, influences the quality and curative effect of final finished.It is (sweet that this law directlys adopt auxiliary material aqueous solution
Careless limewash) it impregnates, while protecting effective component and improving production efficiency, it can also reach detoxification effect, avoid rancid
The appearance of situation, it is ensured that the safety of medicine materical crude slice is taken.
As further preferred scheme, when the tuber of pinellia thin slice is with a thickness of 1.5mm, the rotary heat-insulating pressure maintaining is impregnated
Pressure in tank is maintained at 0.3MPa, and temperature is maintained at 55 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation
Once, each rotary heat-insulating pressure maintaining steeping tank is to rotate 10min, rotation speed 10r/ along clockwise, counterclockwise each
min；It is impregnated for 24 hours in rotary heat-insulating pressure maintaining steeping tank；
When the tuber of pinellia thin slice is with a thickness of 2mm, the pressure in the rotary heat-insulating pressure maintaining steeping tank is maintained at
0.4MPa, temperature are maintained at 58 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and rotation is protected every time
Warm pressure maintaining steeping tank is to rotate 12min, rotation speed 12r/min along clockwise, counterclockwise each；It is protected in rotary heat-insulating
Immersion 28h is carried out in pressure steeping tank；
When the tuber of pinellia thin slice is with a thickness of 2.5mm, the pressure in the rotary heat-insulating pressure maintaining steeping tank is maintained at
0.45MPa, temperature are maintained at 65 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and rotation is protected every time
Warm pressure maintaining steeping tank is to rotate 15min, rotation speed 15r/min along clockwise, counterclockwise each；It is protected in rotary heat-insulating
Immersion 36h is carried out in pressure steeping tank.
The present invention also provides a kind of rhizoma pinellinae praeparata medicine materical crude slice, processing procedure is made the rhizoma pinellinae praeparata medicine materical crude slice as described above.
In addition, rhizoma pinellinae praeparata medicine materical crude slice is made in processing procedure as described above or rhizoma pinellinae praeparata medicine materical crude slice as described above exists
Preparation is for treating the application in abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo or the pharmaceutical composition of phlegm and headache.
Embodiment 1
A kind of rhizoma pinellinae praeparata processing procedure, includes the following steps：
The step of slice：The tuber of pinellia is cut into the tuber of pinellia thin slice with a thickness of 1.5mm；
The step of configuring Radix Glycyrrhizae lime liquor：It takes the licorice tablet of tuber of pinellia flake weight 18% to be placed in extractor, Radix Glycyrrhizae is added
The water of 6 times of amounts of sheet weight carries out first time decoction, decocts temperature and is maintained at 75 DEG C, decocting time 1h, decoction liquor filtering divides
From filtrate and filter residue；The water that 4 times of amounts of Radix Glycyrrhizae sheet weight are added in filter residue carries out second and decocts, and decocts temperature and is maintained at 80 DEG C,
Decocting time is 0.5h, and filtering merges filtrate twice；The quick lime of tuber of pinellia flake weight 7%, pH are added in resulting filtrate
Value keeps 12 or more, stirs evenly, obtains Radix Glycyrrhizae lime liquor；
The step of rotary heat-insulating pressure maintaining is impregnated：Tuber of pinellia thin slice is directly added into Radix Glycyrrhizae lime liquor, rotary heat-insulating is placed in
It is impregnated in pressure maintaining steeping tank for 24 hours, the pressure in rotary heat-insulating pressure maintaining steeping tank is maintained at 0.3MPa, and temperature is maintained at 55
℃；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and each rotary heat-insulating pressure maintaining steeping tank is along suitable
Hour hands, counterclockwise each rotation 10min, rotation speed 10r/min；It takes out；
Dry step：Tuber of pinellia thin slice after immersion is put in a drying box to be dried using gradient heating, is adopted
Be initial temperature with the condition of gradient heating it is 50 DEG C, keeps 2h；0.5 DEG C/5min is warming up to 70 DEG C, then keeps 3h, i.e.,
It does in the proper way Pinellia ternata decoction pieces.
Embodiment 2
A kind of rhizoma pinellinae praeparata processing procedure, includes the following steps：
The step of slice：The tuber of pinellia is cut into the tuber of pinellia thin slice with a thickness of 2mm；
The step of configuring Radix Glycyrrhizae lime liquor：It takes the licorice tablet of tuber of pinellia flake weight 20% to be placed in extractor, Radix Glycyrrhizae is added
The water of 7 times of amounts of sheet weight carries out first time decoction, decocts temperature and is maintained at 80 DEG C, decocting time 1.5h, and decoction liquor filters,
Separating filtrate and filter residue；The water that 5 times of amounts of Radix Glycyrrhizae sheet weight are added in filter residue carries out second and decocts, and decocts temperature and is maintained at 83
DEG C, decocting time 0.8h, filtering merges filtrate twice；The life stone of tuber of pinellia flake weight 8.5% is added in resulting filtrate
Ash, pH value keep 12 or more, stir evenly, obtain Radix Glycyrrhizae lime liquor；
The step of rotary heat-insulating pressure maintaining is impregnated：Tuber of pinellia thin slice is directly added into Radix Glycyrrhizae lime liquor, rotary heat-insulating is placed in
Immersion 28h is carried out in pressure maintaining steeping tank, the pressure in rotary heat-insulating pressure maintaining steeping tank is maintained at 0.4MPa, and temperature is maintained at 58
℃；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and each rotary heat-insulating pressure maintaining steeping tank is along suitable
Hour hands, counterclockwise each rotation 12min, rotation speed 12r/min；It takes out；
Dry step：Tuber of pinellia thin slice after immersion is put in a drying box to be dried using gradient heating, is adopted
Be initial temperature with the condition of gradient heating it is 50 DEG C, keeps 2.5h；0.5 DEG C/5min is warming up to 70 DEG C, then keeps
3.5h is to get rhizoma pinellinae praeparata medicine materical crude slice.
Embodiment 3
A kind of rhizoma pinellinae praeparata processing procedure, includes the following steps：
The step of slice：The tuber of pinellia is cut into the tuber of pinellia thin slice with a thickness of 2.5mm；
The step of configuring Radix Glycyrrhizae lime liquor：It takes the licorice tablet of tuber of pinellia flake weight 22% to be placed in extractor, Radix Glycyrrhizae is added
The water of 8 times of amounts of sheet weight carries out first time decoction, decocts temperature and is maintained at 85 DEG C, decocting time 2h, decoction liquor filtering divides
From filtrate and filter residue；The water that 6 times of amounts of Radix Glycyrrhizae sheet weight are added in filter residue carries out second and decocts, and decocts temperature and is maintained at 85 DEG C,
Decocting time is 1h, and filtering merges filtrate twice；The quick lime of tuber of pinellia flake weight 10%, pH are added in resulting filtrate
Value keeps 12 or more, stirs evenly, obtains Radix Glycyrrhizae lime liquor；
The step of rotary heat-insulating pressure maintaining is impregnated：Tuber of pinellia thin slice is directly added into Radix Glycyrrhizae lime liquor, rotary heat-insulating is placed in
Immersion 36h is carried out in pressure maintaining steeping tank, the pressure in rotary heat-insulating pressure maintaining steeping tank is maintained at 0.45MPa, and temperature is maintained at 65
℃；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and each rotary heat-insulating pressure maintaining steeping tank is along suitable
Hour hands, counterclockwise each rotation 15min, rotation speed 15r/min；It takes out；
Dry step：Tuber of pinellia thin slice after immersion is put in a drying box to be dried using gradient heating, is adopted
Be initial temperature with the condition of gradient heating it is 50 DEG C, keeps 3h；0.5 DEG C/5min is warming up to 70 DEG C, then keeps 4h, i.e.,
It does in the proper way Pinellia ternata decoction pieces.
Effect assessment and performance detection
Appearance in rhizoma pinellinae praeparata medicine materical crude slice made from embodiment 1-3 and effective component are detected, detection project and result
Referring to table 1.With《Chinese Pharmacopoeia》2015 editions rhizoma pinellinae praeparata preparation methods as a comparison case 1.The tuber of pinellia is processed by Radix Glycyrrhizae, and glycyrrhizic acid is in method
Important function is also played in the tuber of pinellia, therefore, active constituent content is with the total alkaloid of the tuber of pinellia and the content of glycyrrhizic acid into measurement.
Wherein the measurement of total alkaloid is as follows：Each 5.0g of sample powder is weighed, respectively plus the 75% ethanol solution 75m of 1%HCI
L, water-bath refluxing extraction 2 times, each 3h, filtration, merging filtrate.Ethyl alcohol is flung to, 50ml is added water to, with 1.5% sulfuric acid solution tune
PH to 1 extracts 3 times (3 × 20ml) with chloroform, merges chloroform, in the beaker weighed is moved into after being washed with water and waves most chloroform,
60 DEG C are dried under vacuum to constant weight, calculate total alkali.
The measurement of glycyrrhizic acid is as follows：Each 5.0g of sample powder is weighed, is set in 200ml flask, with 3% nitric acid acetone soln
50ml impregnates 1h, often shakes, and extract is filtered in 100ml graduated cylinder, and residue is washed with acetone 10m, then is washed residue with 20ml
Entering in flask, then water-bath reflux 5min, extract are filtered in commercial weight cylinder with original filter again, residue reusable heat acetone leaches 2 times, and
Washing is poured into 250ml beaker, graduated cylinder is incorporated in beaker with the flushing of 80ml ethyl alcohol, concentrated ammonia liquor is instilled when shaking to 100ml
L.8m1, ammonium glycyrrhetate precipitating is obtained, decompression filters.And it is washed 2~3 times with acetone 50m l.Precipitating is put into former beaker, adds water
25m1 dissolution, is added the formalin 20m1 neutralized, after placing lmin, is titrated to caustic lye of soda (0.1mol/L) molten
Liquid becomes red from yellow.The quite dry 27.3mg glycyrrhizic acid of the caustic lye of soda (0.1mol/L) of every lml.
1 rhizoma pinellinae praeparata medicine materical crude slice of 1 embodiment 1-3 of table and comparative example
Appearance and active constituent content testing result
As shown in Table 1, with《Chinese Pharmacopoeia》Preparation method compare, method made from rhizoma pinellinae praeparata processing procedure provided by the present invention
The content of the effective component of the tuber of pinellia, alkaloid and enoxolone is more relatively high than the effective content of traditional preparation method, illustrates
The present invention can be effectively retained effective component, avoid ingredients from lossing；In addition, the present invention compares, process time greatly shortens, greatly
Improve production efficiency.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (9)
1. a kind of rhizoma pinellinae praeparata processing procedure, which is characterized in that include the following steps：
The step of slice：The tuber of pinellia is cut into tuber of pinellia thin slice；
The step of configuring Radix Glycyrrhizae lime liquor：Extracting liquorice piece is placed in extractor, and water is added and carries out first time decoction, decoction liquor mistake
Filter, separating filtrate and filter residue；Filter residue is added water and carries out second of decoction, and filtering merges filtrate twice；Add in resulting filtrate
Enter quick lime, pH value keeps 12 or more, stirs evenly, obtain Radix Glycyrrhizae lime liquor；
The step of rotary heat-insulating pressure maintaining is impregnated：Tuber of pinellia thin slice is directly added into Radix Glycyrrhizae lime liquor, rotary heat-insulating pressure maintaining is placed in
Immersion 24-36h is carried out in steeping tank, is taken out；
Dry step：Tuber of pinellia thin slice after immersion, which is put in a drying box, to be dried using gradient heating to get method
Pinellia ternata decoction pieces.
2. rhizoma pinellinae praeparata processing procedure as described in claim 1, which is characterized in that in the step of being sliced, the tuber of pinellia thin slice
With a thickness of 1.5-2.5mm.
3. rhizoma pinellinae praeparata processing procedure as described in claim 1, which is characterized in that in the step of configuring Radix Glycyrrhizae lime liquor, institute
State the 18-22% that Radix Glycyrrhizae is tuber of pinellia flake weight；The quick lime is the 7-10% of tuber of pinellia flake weight.
4. rhizoma pinellinae praeparata processing procedure as described in claim 1, which is characterized in that in the step of configuring Radix Glycyrrhizae lime liquor, the
Amount of water when primary decoction is 6-8 times of Radix Glycyrrhizae sheet weight, decocts temperature and is maintained at 75-85 DEG C, decocting time 1-2h；The
Amount of water when secondary decoction is 4-6 times of Radix Glycyrrhizae sheet weight, decocts temperature and is maintained at 80-85 DEG C, decocting time 0.5-1h.
5. rhizoma pinellinae praeparata processing procedure as described in claim 1, which is characterized in that in the step of rotary heat-insulating pressure maintaining is impregnated,
Pressure in the rotary heat-insulating pressure maintaining steeping tank is maintained at 0.3-0.45MPa, and temperature is maintained at 55-65 DEG C；The process of immersion
In, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and each rotary heat-insulating pressure maintaining steeping tank is along side clockwise, counterclockwise
To each rotation 10-15min, rotation speed 10-15r/min.
6. rhizoma pinellinae praeparata processing procedure as claimed in claim 5, which is characterized in that when the tuber of pinellia thin slice is with a thickness of 1.5mm
When, the pressure in the rotary heat-insulating pressure maintaining steeping tank is maintained at 0.3MPa, and temperature is maintained at 55 DEG C；During immersion, often
The rotation of 3h rotary heat-insulating pressure maintaining steeping tank is primary, and each rotary heat-insulating pressure maintaining steeping tank is along clockwise, counterclockwise each
Rotate 10min, rotation speed 10r/min；It is impregnated for 24 hours in rotary heat-insulating pressure maintaining steeping tank；
When the tuber of pinellia thin slice is with a thickness of 2mm, the pressure in the rotary heat-insulating pressure maintaining steeping tank is maintained at 0.4MPa, temperature
Degree is maintained at 58 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and each rotary heat-insulating pressure maintaining is impregnated
Tank is to rotate 12min, rotation speed 12r/min along clockwise, counterclockwise each；In rotary heat-insulating pressure maintaining steeping tank
Carry out immersion 28h；
When the tuber of pinellia thin slice is with a thickness of 2.5mm, the pressure in the rotary heat-insulating pressure maintaining steeping tank is maintained at
0.45MPa, temperature are maintained at 65 DEG C；During immersion, every 3h rotary heat-insulating pressure maintaining steeping tank rotation is primary, and rotation is protected every time
Warm pressure maintaining steeping tank is to rotate 15min, rotation speed 15r/min along clockwise, counterclockwise each；It is protected in rotary heat-insulating
Immersion 36h is carried out in pressure steeping tank.
7. rhizoma pinellinae praeparata processing procedure as described in claim 1, which is characterized in that described to use gradient in dry step
The condition of temperature-raising method is that initial temperature is 50 DEG C, keeps 2-3h；0.5 DEG C/5min is warming up to 70 DEG C, then keeps 3-4h.
8. a kind of rhizoma pinellinae praeparata medicine materical crude slice, which is characterized in that the rhizoma pinellinae praeparata medicine materical crude slice is according to processing of any of claims 1-7
Technique is made.
9. according to claim 8 rhizoma pinellinae praeparata medicine materical crude slice preparation for treat abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo or
Application in the pharmaceutical composition of phlegm and headache.
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