CN108853020A - A kind of pet emulsion and its preparation process of replenishing the calcium - Google Patents

A kind of pet emulsion and its preparation process of replenishing the calcium Download PDF

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CN108853020A
CN108853020A CN201811026165.0A CN201811026165A CN108853020A CN 108853020 A CN108853020 A CN 108853020A CN 201811026165 A CN201811026165 A CN 201811026165A CN 108853020 A CN108853020 A CN 108853020A
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calcium
emulsion
pet
oil
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崔心江
刘建柱
安伯玉
张录娟
初殿霞
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Shandong Asia China Biotech Co Ltd
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Shandong Asia China Biotech Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/191Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

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Abstract

The present invention provides a kind of pet emulsion of replenishing the calcium, the emulsion, including following raw material components:Calcium gluconate, VD3 oil, pharmaceutical grade soybean oil, Arlacel-80, Tween-80, xanthan gum, fresh milk powdered flavor, sweet orange oil essence, citric acid, microcrystalline cellulose, white granulated sugar, honey, potassium sorbate, sodium benzoate, purified water.Emulsion of the present invention is widely used in the pets supplement calcium such as the dog of each age group, cat.Strengthen calcareous absorption, the effect of Psoralen is good for tooth.(1)Gestation, nursing period pet calcareous supplement, prevent and treat postpartum paralysis, fetal bone depauperation, promote after being ill, Recovery.(2)It supplements calcareous needed for the bone normal growth and development of teenage pet.(3)Prevent aged pet osteoporosis, calcium loss, and leads to the diseases such as easy fracture, cramp, lumbar pain, moving difficulty.

Description

A kind of pet emulsion and its preparation process of replenishing the calcium
Technical field
The present invention relates to pet veterinary drug technical field more particularly to a kind of pet dogs, the composition group of the emulsion of replenishing the calcium of cat At and preparation method thereof.
Background technique
The height of each national economic development development degree and living standards of the people, the quantity with pet have close pass System.Domestic economy is after how many years precipitatings, and the pets such as dog, cat have entered common people house, and price is from several hundred to hundreds of thousands Differ;So the family of each income stratum can obtain and take in the pet to match with oneself.The pets such as dog, cat with Clever and sensible, understanding advantage has been increasingly becoming the first choice of majority.Although the rising suddenly of pet quantity, and matter Amount is still in slow development process.
Pet has a fixed immune process, goes to vaccinate by specified period, and vaccine is also not omnipotent, and number Amount and type are limited.So the problem of this or that can also occur as people in pet body, wherein calcium deficiency or because of calcium deficiency Caused by disease be exactly a significant problem.It replenishes the calcium and further relates to several critical stages:The gestational period, produces the development of fetus phase Afterwards, nursing period, after being ill and postpartum recovery phase, aged calcium loss etc..It is good for product when forefathers' medical insurance to cover the sky and the earth, from baby to old man Can be described as very it is more, many brands are stood in great numbers;And the opposite shortage of this plate of animal doctor, product is extremely rare, and confusion is grown thickly, It is mostly replenished the calcium with functional food, ointment, health food, and calcium supplementing product composition is again with calcium lactate and calcium phosphate most commonly seen, But both inorganic calciums are more difficult when absorbing through biomembrane, and absorption is caused to slow down;
Therefore above-mentioned calcium-supplementing preparation absorbs relative difficult, and speed of replenishing the calcium is slower.So Vehicles Collected from Market lack it is a kind of absorption more rapidly, Curative effect is better, the shorter effective pet drug calcium supplement of medication cycle.
Summary of the invention
To solve deficiencies of the prior art, the present invention provides a kind of pet emulsion and its preparation work of replenishing the calcium Skill, to realize following goal of the invention:
(1)Medication cycle is short, and rehabilitation rate is high;
(2)Convenient oral, dosage are accurate, easily absorb, curative effect collaboration, reach calcium supplement for pet requirement;
To solve the above-mentioned problems, the present invention uses following technical scheme:
A kind of pet is prepared from the following raw materials in parts by weight with the emulsion and its preparation process, the emulsion replenished the calcium:
1.0-3.0 parts of calcium gluconate;0.001-0.009 parts of VD3 oil;0.8-2.4 parts of pharmaceutical grade soybean oil;Arlacel-80 1.0 Part;0.6 part of Tween-80;0.04-0.20 parts of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;Citric acid 0.08 part;1.0-3.0 parts of microcrystalline cellulose;2.0-6.0 parts of white granulated sugar;1.0-3.0 parts of honey;0.4 part of potassium sorbate;Benzoic acid 0.08 part of sodium;Purified Water q. s add to 42 parts.
It is that the present invention advanced optimizes above scheme below:
2.0 parts of calcium gluconate;0.005 part of VD3 oil;1.6 parts of pharmaceutical grade soybean oil;1.0 parts of Arlacel-80;Tween-80 0.6 Part;0.12 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid;Microcrystalline cellulose 2.0 Part;4.0 parts of white granulated sugar;2.0 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s add to 42 parts.
Another kind optimization:1.0 parts of calcium gluconate;0.001 part of VD3 oil;0.8 part of pharmaceutical grade soybean oil;Arlacel-80 1.0 Part;0.6 part of Tween-80;0.04 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid; 1.0 parts of microcrystalline cellulose;2.0 parts of white granulated sugar;1.0 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s Add to 42 parts.
Another kind optimization:1.5 parts of calcium gluconate;0.003 part of VD3 oil;1.2 parts of pharmaceutical grade soybean oil;Arlacel-80 1.0 Part;0.6 part of Tween-80;0.08 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid; 1.5 parts of microcrystalline cellulose;3.0 parts of white granulated sugar;1.5 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s Add to 42 parts.
Another kind optimization:2.5 parts of calcium gluconate;0.007 part of VD3 oil;2.0 parts of pharmaceutical grade soybean oil;Arlacel-80 1.0 Part;0.6 part of Tween-80;0.16 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid; 2.5 parts of microcrystalline cellulose;5.0 parts of white granulated sugar;2.5 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s Add to 42 parts.
Another kind optimization:3.0 parts of calcium gluconate;0.009 part of VD3 oil;2.4 parts of pharmaceutical grade soybean oil;Arlacel-80 1.0 Part;0.6 part of Tween-80;0.20 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid; 3.0 parts of microcrystalline cellulose;6.0 parts of white granulated sugar;3.0 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s Add to 42 parts.
The present invention also provides a kind of pet preparation processes for emulsion of replenishing the calcium, and include the following steps:
1, first purified water boiled, sterilized 15 minutes;
2, it takes 20 parts of boiling water to dissolve calcium gluconate, the xanthan gum and white granulated sugar mixed in advance is added, is constantly stirred with 57r/min It mixes until agglutination liquid 1;
3, it takes 2 parts of room temperature purified waters that potassium sorbate dissolution is added in above-mentioned colloidal liquid 1, obtains colloidal liquid 2;
4, honey is uniformly dissolved with 5 parts of boiling water in advance, is added in colloidal liquid 2, obtains colloidal liquid 3;
5, pharmaceutical grade soybean oil, VD3 oil, Tween-80, Arlacel-80 are mixed, colloidal liquid 3 is poured into, it is continuous with 57r/min Stirring, obtains liquid a;
6,0.5 part of room temperature purified water dissolution of citric acid is added in aforesaid liquid a, obtains liquid b,
7,0.5 part of room temperature purified water dissolution of sodium benzoate is added in aforesaid liquid b, obtains liquid c;
8, microcrystalline cellulose, fresh milk powdered flavor, sweet orange oil essence are sequentially added into aforesaid liquid c, it is equal with 57r/min stirring It is even, it is quantitative to 42 parts with purified water, obtain liquid d;
9, by prepared liquid d colloid mill(Partial size 2um)Grinding 2 times, homogenizer(40Mpa;35℃;Partial size 2um;Duration 10min/ 40L)Homogeneous 4 times.It is dispensed after detection is qualified.
Compared with prior art, the beneficial effect that the present invention obtains:
1, emulsion of the present invention is widely used in the pets supplement calcium such as the dog of each age group, cat.Strengthen calcareous absorption, mends Bone is good for the effect of tooth.(1)Gestation, the calcareous supplement of nursing period pet prevent and treat postpartum paralysis, fetal bone development not It is good, promote after being ill, Recovery.(2)It supplements calcareous needed for the bone normal growth and development of teenage pet.It plays prevention and controls It treats osteomalacia and calcium source lacks for arthritis, soft, rickets of leg caused by inducement etc..(3)Prevent aged pet sclerotin to dredge Pine, calcium loss, and lead to the diseases such as easy fracture, cramp, lumbar pain, moving difficulty.The present invention relates to supplement calcium, and it is strong The effect of changing calcareous absorption.
2, emulsion of the present invention has good effect of supplemented calcium for the gestational period of single calcium deficiency or the pet of nursing period, The gravidic pet dog of single calcium deficiency takes the present invention and replenishes the calcium emulsion, and the 4th day rehabilitation rate was up to 83% or more, the 7th day(1 treatment Journey)Rehabilitation rate up to 100%;The pet dog of the nursing period of single calcium deficiency takes the present invention and replenishes the calcium emulsion, and the 7th day(1 course for the treatment of) Rehabilitation rate up to 88.6%;14th day(2 courses for the treatment of)Rehabilitation rate up to 97% or more.
3, emulsion of the present invention has good effect of supplemented calcium for non-pregnant and lactation the pet of single calcium deficiency, It takes the present invention to replenish the calcium emulsion, the 7th day rehabilitation rate is 83-90%;The 14th day rate that fully recovers is 96.7-100%, efficient Up to 100%.
4, pet of the emulsion of the present invention for single calcium deficiency(Include the gestational period or nursing period), there is good replenish the calcium Effect,
The use of the 4th day rehabilitation rate of product of the present invention is 45%, treatment cycle can be made to be obviously shortened;First course for the treatment of, rehabilitation rate are 80% or more, the second course for the treatment of rehabilitation rate is 97.5% or more;
Using the control group of existing product, the 4th day rehabilitation rate is 27.5-40%;The rehabilitation rate of first course for the treatment of is 60-75%;The The rehabilitation rate of two courses for the treatment of is 85-92.5%;
The rehabilitation rate of the comparison of the product of product of the present invention and the prior art, first course for the treatment of improves 5-20 percentage points, second course for the treatment of Rehabilitation rate improves 5 to 12 percentage points, and product of the present invention is treated the 4th day, and rehabilitation rate is up to 45%;The prior art is up to 40%, generally below 30%.
5, the present invention is replenished the calcium with Drug and is occurred with the dosage form of emulsion, this market is blank.Because being incorporated in emulsion Oily phase or cosolvent are easier to through biomembrane, and infiltration rate is accelerated, while overcoming emulsion technique by colloid mill and homogenizer Middle stability problem, wide market.
Below by specific embodiment, the invention will be further described, but the present invention is not limited by following embodiment.
Specific embodiment
A kind of pet emulsion of replenishing the calcium, the emulsion are made of raw material from the following weight:
The proportion of the emulsion of replenishing the calcium of pet described in 1 embodiment 1-5 of table
Embodiment 3 is preferred embodiment.
The application test of the emulsion of the present invention of replenishing the calcium of embodiment 6
The present invention carries out following tests using product described in embodiment 3:
Pet test site:Pet dog breeding farm A(Weifang), pet dog breeding farm B(Weifang)With pet clinic C(Weifang), dote on Object hospital D(Qingdao), add up to four part test places.
Operational staff:4 practising veterinarians are worked at a selected spot and are tested, and collect record test data, practising veterinarian teacher needs before testing It carries out routine examination, Pass Test is required with dog, and is diagnosed as single calcium deficiency case.
It is related to case 883 in test in total, farm's kind of dog 7, outpatient service kind of dog 17, across the gestational period, childhood, not Adult, adult, aged 5 stages;Random experiment is taken, and sets up blank control and product control, it is serious depending on weight and infection Degree is administered orally, and result is observed and recorded.
Diagnosis method:
1. Biochemical Analyzer measures blood calcium value(Normal range (NR) 7.8-11.3mg/dL), there is hypocalcemia lower than the lowest limit.
2. combining clinical symptoms:There is bone bending, claw of lying prone, face's itch, more dynamic uneasy, muscular tremors or muscle bundle to quiver Dynamic, hind leg spasm etc..
Slight calcium deficiency:The critical low value of blood calcium value, symptom are not obvious.
Moderate calcium deficiency:For blood calcium value already below the lowest limit, calcium deficiency symptom is obvious, and the medicine of replenishing the calcium for taking orally certain course for the treatment of can be controlled It treats.
Severe calcium deficiency:It such as happens suddenly and high temperature and twitches and cannot stand, need promptly to be infused, relief etc., by not taken orally not It can solve problem.
Rehabilitation criterion:Clinical symptoms disappear, and blood calcium value, which returns to, can be determined as rehabilitation in normal range (NR).
Medication:
Test group:It is oral, each 2-3ml of dog weight 5kg or less;The each 3-5ml of 5-10kg weight;More than 10kg weight each 5- 10ml can be instilled directly in food and be freely eaten 2 times a day.The 1-2 course for the treatment of is used in conjunction(One the course for the treatment of 7 days).
Test result is as follows:
(1)Gestation, nursing period test result:
(Dog breeding farm)Golden hair, safe each 8 of the enlightening gestational period(Test+control), nursing period mixes 40 total(Test+control), The above test dog sample standard deviation is diagnosed as single calcium deficiency performance, and calcium deficiency situation is between first, mid-term.
Table 2 is of the present invention to replenish the calcium emulsion to the effect of supplemented calcium of the pet dog of gestation, nursing period
Seen from table 1, the gravidic pet dog of single calcium deficiency takes the present invention and replenishes the calcium emulsion, the 4th day rehabilitation rate up to 83% with On, the 7th day(1 course for the treatment of)Rehabilitation rate up to 100%;The pet dog of the nursing period of single calcium deficiency takes the present invention and replenishes the calcium emulsion, 7th day(1 course for the treatment of)Rehabilitation rate up to 88.6%;14th day(2 courses for the treatment of)Rehabilitation rate up to 97% or more.Gestation and nursing period pair According to group, there is within the 7th day calcium deficiency exacerbation of symptoms, calcium deficiency serious symptoms occurs within the 14th day.
The present invention treats based on first, mid-term calcium deficiency, the calcium deficiency that confounding factor induces, such as infectious disease, serious organ function Energy property malabsorption etc., can only assist in the treatment of, cannot be used alone.
(2)Farm part does not include gestation and nursing period in following tests result;Clinic is divided into mixing statistics, includes Outpatient service all situations case(Containing gestation and nursing period).
Diagnostic result before test:All pet dogs are diagnosed as single calcium deficiency before the test;
Application method:Test group 4-7 is oral or instills quantitative food free choice feeding;Control group 4-7 feeds equivalent pure water.
Test result is shown in Table 3.
Table 3
It is for the non-pregnant test result with the pet dog of lactation:The 7th day rehabilitation rate in two dog breeding farms is 83-90%;The 14 days rates that fully recover are 96.7-100%, efficient up to 100%.
For mixing outpatient service(Containing gestation and nursing period)Pet test result:Dog the 14th day of Liang Jia hospital it is complete Rehabilitation rate is 95.7-96%, and effective percentage is 98.8-99.5%, and therapeutic effect is significant.
There is within control group the 7th day calcium deficiency exacerbation, it is serious calcium deficiency occur within the 14th day.
(3)Similar product comparative test:
The contrast effect of table 4 product of the present invention and existing product
Note:Control group is 4 groups, and test group 8 is using product of the present invention, and control group 9,10 uses presently commercially available product(At present Dog breeding is with product);Control group 11,12 is current Liang Jia pet clinic with product.
As a result:The use of the 4th day rehabilitation rate of product of the present invention is 45% from the point of view of test result analysis, treatment week can be made Phase is obviously shortened;First course for the treatment of, rehabilitation rate are 80% or more, and the second course for the treatment of rehabilitation rate is 97.5% or more;Control group, the 4th day Rehabilitation rate is 27.5-40%;The rehabilitation rate of first course for the treatment of is 60-75%;The rehabilitation rate of second course for the treatment of is 85-92.5%;
The rehabilitation rate of the comparison of the product of product of the present invention and the prior art, first course for the treatment of improves 5-20 percentage points, second course for the treatment of Rehabilitation rate improves 5 to 12 percentage points, and product of the present invention is treated the 4th day, and rehabilitation rate is up to 45%;The prior art is up to 40%, generally below 30%.
Above-described embodiment is all to be conceived using this and actually made for illustrating inventive concept and actual use of the invention With making a non-material change to the present invention, protection scope of the present invention should all be fallen into.

Claims (8)

1. a kind of pet emulsion of replenishing the calcium, it is characterised in that:The emulsion, including following raw material components:Calcium gluconate, VD3 Oil, pharmaceutical grade soybean oil, Arlacel-80, Tween-80, xanthan gum, fresh milk powdered flavor, sweet orange oil essence, citric acid, crystallite are fine Tie up element, white granulated sugar, honey, potassium sorbate, sodium benzoate, purified water.
2. a kind of pet emulsion of replenishing the calcium according to claim 1, it is characterised in that:The emulsion, in parts by weight, packet Include following components:1.0-3.0 parts of calcium gluconate;0.001-0.009 parts of VD3 oil;0.8-2.4 parts of pharmaceutical grade soybean oil;Sapn- 80 1.0 parts;0.6 part of Tween-80;0.04-0.20 parts of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;Lemon 0.08 part of lemon acid;1.0-3.0 parts of microcrystalline cellulose;2.0-6.0 parts of white granulated sugar;1.0-3.0 parts of honey;0.4 part of potassium sorbate;Benzene 0.08 part of sodium formate;Purified Water q. s add to 42 parts.
3. a kind of pet emulsion of replenishing the calcium according to claim 1, it is characterised in that:The emulsion, in parts by weight, packet Include following components:2.0 parts of calcium gluconate;0.005 part of VD3 oil;1.6 parts of pharmaceutical grade soybean oil;1.0 parts of Arlacel-80;Tween- 80 0.6 parts;0.12 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid;Microcrystalline cellulose 2.0 parts of element;4.0 parts of white granulated sugar;2.0 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s add to 42 Part.
4. a kind of pet emulsion of replenishing the calcium according to claim 1, it is characterised in that:The emulsion, in parts by weight, packet Include following components:1.0 parts of calcium gluconate;0.001 part of VD3 oil;0.8 part of pharmaceutical grade soybean oil;1.0 parts of Arlacel-80;Tween- 80 0.6 parts;0.04 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid;Microcrystalline cellulose 1.0 parts of element;2.0 parts of white granulated sugar;1.0 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s add to 42 Part.
5. a kind of pet emulsion of replenishing the calcium according to claim 1, it is characterised in that:The emulsion, in parts by weight, packet Include following components:1.5 parts of calcium gluconate;0.003 part of VD3 oil;1.2 parts of pharmaceutical grade soybean oil;1.0 parts of Arlacel-80;Tween- 80 0.6 parts;0.08 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid;Microcrystalline cellulose 1.5 parts of element;3.0 parts of white granulated sugar;1.5 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s add to 42 Part.
6. a kind of pet emulsion of replenishing the calcium according to claim 1, it is characterised in that:The emulsion, in parts by weight, packet Include following components:2.5 parts of calcium gluconate;0.007 part of VD3 oil;2.0 parts of pharmaceutical grade soybean oil;1.0 parts of Arlacel-80;Tween- 80 0.6 parts;0.16 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid;Microcrystalline cellulose 2.5 parts of element;5.0 parts of white granulated sugar;2.5 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s add to 42 Part.
7. a kind of pet emulsion of replenishing the calcium according to claim 1, it is characterised in that:The emulsion, in parts by weight, packet Include following components:3.0 parts of calcium gluconate;0.009 part of VD3 oil;2.4 parts of pharmaceutical grade soybean oil;1.0 parts of Arlacel-80;Tween- 80 0.6 parts;0.20 part of xanthan gum;0.2 part of fresh milk powdered flavor;0.2 part of sweet orange oil essence;0.08 part of citric acid;Microcrystalline cellulose 3.0 parts of element;6.0 parts of white granulated sugar;3.0 parts of honey;0.4 part of potassium sorbate;0.08 part of sodium benzoate;Purified Water q. s add to 42 Part.
8. a kind of pet preparation process for emulsion of replenishing the calcium, it is characterised in that:The preparation process, includes the following steps:
(1)First purified water is boiled, is sterilized 15 minutes;
(2)It takes 20 parts of boiling water to dissolve calcium gluconate, the xanthan gum and white granulated sugar mixed in advance is added, it is continuous with 57r/min Stirring is until agglutination liquid 1;
(3)It takes 2 parts of room temperature purified waters that potassium sorbate dissolution is added in above-mentioned colloidal liquid 1, obtains colloidal liquid 2;
(4)Honey is uniformly dissolved in advance with 5 parts of boiling water, is added in colloidal liquid 2, obtains colloidal liquid 3;
(5)Pharmaceutical grade soybean oil, VD3 oil, Tween-80, Arlacel-80 are mixed, colloidal liquid 3 is poured into, it is continuous with 57r/min Stirring, obtains liquid a;
(6)0.5 part of room temperature purified water dissolution of citric acid is added in aforesaid liquid a, liquid b is obtained,
(7)0.5 part of room temperature purified water dissolution of sodium benzoate is added in aforesaid liquid b, liquid c is obtained;
(8)Microcrystalline cellulose, fresh milk powdered flavor, sweet orange oil essence are sequentially added into aforesaid liquid c, it is equal with 57r/min stirring It is even, it is quantitative to 42 parts with purified water, obtain liquid d;
(9)The prepared liquid d colloid mill of partial size 2um is ground 2 times, homogeneous 4 times;The homogeneous, parameter setting:Pressure For 40Mpa, temperature is 35 DEG C, partial size 2um, when homogeneous a length of 10min/40L.
CN201811026165.0A 2018-09-04 2018-09-04 A kind of pet emulsion and its preparation process of replenishing the calcium Pending CN108853020A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102920714A (en) * 2012-11-26 2013-02-13 哈尔滨市华农威普动物保健品有限公司 Oral calcium supplement for cow-multi-vitamin colloidal calcium emulsion and preparation method of same
KR101401884B1 (en) * 2012-08-21 2014-05-29 가톨릭대학교 산학협력단 Composition for calcium uptake comprising mineral water
CN105581041A (en) * 2015-12-12 2016-05-18 江苏雅博动物保健品有限责任公司 High calcium emulsion for promoting pet joint repair and preparation method thereof
CN106581061A (en) * 2016-12-18 2017-04-26 杨箭 High-calcium emulsion for pet joint repair and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101401884B1 (en) * 2012-08-21 2014-05-29 가톨릭대학교 산학협력단 Composition for calcium uptake comprising mineral water
CN102920714A (en) * 2012-11-26 2013-02-13 哈尔滨市华农威普动物保健品有限公司 Oral calcium supplement for cow-multi-vitamin colloidal calcium emulsion and preparation method of same
CN105581041A (en) * 2015-12-12 2016-05-18 江苏雅博动物保健品有限责任公司 High calcium emulsion for promoting pet joint repair and preparation method thereof
CN106581061A (en) * 2016-12-18 2017-04-26 杨箭 High-calcium emulsion for pet joint repair and preparation method thereof

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Application publication date: 20181123