CN109157655A - A kind of compound preparation for pet postoperative rehabilitation - Google Patents

A kind of compound preparation for pet postoperative rehabilitation Download PDF

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Publication number
CN109157655A
CN109157655A CN201811027962.0A CN201811027962A CN109157655A CN 109157655 A CN109157655 A CN 109157655A CN 201811027962 A CN201811027962 A CN 201811027962A CN 109157655 A CN109157655 A CN 109157655A
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Prior art keywords
parts
pet
compound preparation
csad
albumen
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Withdrawn
Application number
CN201811027962.0A
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Inventor
方敏
崔心江
杨瑞锋
赵伟杰
王晓
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Shandong Asia China Biotech Co Ltd
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Shandong Asia China Biotech Co Ltd
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Priority to CN201811027962.0A priority Critical patent/CN109157655A/en
Publication of CN109157655A publication Critical patent/CN109157655A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01029—Sulfinoalanine decarboxylase (4.1.1.29)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
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Abstract

The present invention provides a kind of compound preparation for pet postoperative rehabilitation, the compound preparation, including following raw material components: Csad albumen, saccharicter-penin, Co-Q10, oligofructose, pseudo-ginseng, drying powder, DEXTROSE ANHYDROUS.The compound preparation, in parts by weight, including following raw material components: Csad albumen: 0.10-0.30 parts；Saccharicter-penin: 0.60-2.2 parts；Co-Q10: 0.02-0.12 parts；Oligofructose: 0.60-1.4 parts；Pseudo-ginseng: 0.60-1.4 parts；Drying powder: 0.10 part；DEXTROSE ANHYDROUS adds to 20 parts.Compound preparation of the present invention for the biting of pet, is scratched, is scratched, the treatment of operation wound, and wound-healing cycle is short, and physical recovery is fast；Healing rate is high.

Description

A kind of compound preparation for pet postoperative rehabilitation
Technical field
The present invention relates to the field of biological pharmacy for animals of pet medication more particularly to pet postoperative rehabilitations and promotion body to exempt from Epidemic disease reaches the compound preparation composition composition of anti-infective purpose.
Background technique
After the height of living standards of the people is constantly promoted, income and time is also just more gets up, more most important , have there is the phenomenon that gathering less and separating more to work in people, and this promotes the continuous developments of companion pet industry, especially Big city, pet almost get married front yard standard configuration, or even a variety of pets are supported by the family having.Then again have one it is pleasing to the ear and properer Name " companion animals ", they are treated as one family member.
But new problem produces, and when people put into more and more energy and money, is more returned with regard to expectation Report.With us, health is just aobvious particularly important, and when needing to perform the operation after especially sick, rehabilitation is exactly our institutes fastly It is desired.One be exactly it is anti-infective, second is exactly to promote immunity of organisms, is set about from inside.
The existing postoperative recovery preparation of pet, the thing that similar people cures health care product has much, but existing pet industry Postoperative rehabilitation mostly is carried out based on the physics such as physical therapy, exercising device or device, auxiliary fixing band or boxes and baskets, massage device auxiliary, There are medicine-smoking, pure Chinese medicine to enrich blood, more use antimicrobial, prevent from infecting, other are exactly to suit the medicine to the illness to be administered according to demand.
And these existing pet postoperative rehabilitation forms are there are treatment cycle is long, the low defect of wound healing rate causes Make the time of scalpel wound healing and physical recovery at 7-10 days, can just take out stitches.
Summary of the invention
To solve the shortcomings of the prior art, the present invention provides a kind of compound preparation for pet postoperative rehabilitation, is The postoperative reparation of pet, after being ill rehabilitation, the novel formulation for enhancing immunity of pets, to realize following goal of the invention:
(1) for the biting, scratch, scratching of pet, the treatment of operation wound, wound-healing cycle is short, and physical recovery is fast；
(2) for the biting, scratch, scratching of pet, the treatment of operation wound, healing rate is high.
In order to solve the above-mentioned technical problem, the invention adopts the following technical scheme:
A kind of compound preparation for pet postoperative rehabilitation, said preparation are prepared from the following raw materials in parts by weight: Csad albumen: 0.10-0.30 parts；Saccharicter-penin: 0.60-2.2 parts；Co-Q10: 0.02-0.12 parts；Oligofructose: 0.60-1.4 parts；Pseudo-ginseng: 0.60-1.4 parts；Drying powder: 0.10 part；DEXTROSE ANHYDROUS adds to 20 parts；It amounts to: 20 parts.
It is that the present invention advanced optimizes above scheme below:
The compound preparation is prepared from the following raw materials in parts by weight: Csad albumen: 0.20 part；Saccharicter-penin: 1.4 parts；Co-Q10: 0.06 part；Oligofructose: 1.0 parts；Pseudo-ginseng: 1.0 parts；DEXTROSE ANHYDROUS: 16.24 parts；Drying powder: 0.10 part；It amounts to: 20 parts.
Another kind optimization:
The compound preparation is prepared from the following raw materials in parts by weight: Csad albumen: 0.10 part；Saccharicter-penin: 0.60 part；Co-Q10: 0.02 part；Oligofructose: 0.60 part；Pseudo-ginseng: 0.60 part；DEXTROSE ANHYDROUS: 17.98 parts；Drying powder: 0.10 part；It amounts to: 20 Part.
Another kind optimization:
The compound preparation is prepared from the following raw materials in parts by weight: Csad albumen: 0.15 part；Saccharicter-penin: 1.0 parts；Co-Q10: 0.04 part；Oligofructose: 0.80 part；Pseudo-ginseng: 0.80 part；DEXTROSE ANHYDROUS: 17.11 parts；Drying powder: 0.10 part；It amounts to: 20 Part.
Another kind optimization:
The compound preparation is prepared from the following raw materials in parts by weight: Csad albumen: 0.25 part；Saccharicter-penin: 1.8 parts；Co-Q10: 0.08 part；Oligofructose: 1.2 parts；Pseudo-ginseng: 1.2 parts；DEXTROSE ANHYDROUS: 15.37 parts；Drying powder: 0.10 part；It amounts to: 20 parts.
Another kind optimization:
The compound preparation is prepared from the following raw materials in parts by weight: Csad albumen: 0.30 part；Saccharicter-penin: 2.2 parts；Co-Q10: 0.12 part；Oligofructose: 1.4 parts；Pseudo-ginseng: 1.4 parts；DEXTROSE ANHYDROUS: 14.48 parts；Drying powder: 0.10 part；It amounts to: 20 parts.
In above-mentioned prescription:
Csad albumen: the protein that Csad albumen amino acid sequence shown in SEQ ID NO1 forms, what the present invention used Csad albumen is directly purchased from Institute of Microorganism, Academia Sinica (Beijing).
The present invention also provides a kind of preparation processes of compound preparation for pet postoperative rehabilitation, comprising the following steps:
1, pseudo-ginseng crushed 80 meshes；
2, the pseudo-ginseng crushed level-one is carried out with Csad albumen, Co-Q10, oligofructose to mix；
3, saccharicter-penin, drying powder are added in step 2 gained mixture, carry out second level mixing；
4, the two-stage mixture mixed addition DEXTROSE ANHYDROUS is finally mixed；It is dispensed after detection is qualified.
Beneficial effects of the present invention:
(1) compound preparation of the present invention is widely used in biting, scratch, scratching, performing the operation for the pets such as the cat of each age group, dog The treatment of wound, healing rate is high, accelerates its postoperative rehabilitation.It suppurates to caused by pet cortex fungi, bacterium, virus mixed infection Property wound, Pyoderma have the cracking effect for promoting healing.Invention formulation can greatly shorten the postoperative rehabilitation period, in 5- Wound can heal within 7 days, reach the standard of taking out stitches.It uses for the first time, it is seen that the discharge of surface of a wound fester increases and (belongs to normal phenomenon), then It gradually reduces, while playing the role of promoting wound granulation tissue growth.
(2) compound preparation of the present invention has the effect for promoting wound healing for the simulation operative incision of pet dog Fruit takes the pet dog of invention formulation, and after medication 5 days, wound can heal completely, and the healing rate of operative incision is up to 100%.
(3) compound preparation of the present invention is applied to the operation wound of pet dog in pet clinic, takes the present invention After preparation 5 days (1 course for the treatment of), the healing rate of operation wound is 75-78%；Using existing product, after 5 days (1 course for the treatment of), operation The healing rate of wound is 42-45%；After taking invention formulation 10 days (2 courses for the treatment of), the healing rate of operation wound is 95-98%； Using existing product, after 10 days (1 course for the treatment of), the healing rate of operation wound is 90%.
(4) compound preparation of the present invention is applied to biting, scratch, scratching for pet dog in breeding farm, takes this After invention preparation 5 days (1 course for the treatment of), the healing rate bite, scratch, scratching is 95-100%；Using existing product, (1 after 5 days The course for the treatment of), the healing rate bite, scratch, scratching is 75-85%.
Below by specific embodiment, the invention will be further described, but the present invention is not limited by following embodiment It is fixed.
Specific embodiment
A kind of compound preparation for pet postoperative rehabilitation, the compound preparation are made of raw material from the following weight:
The compound preparation of 1 embodiment 1-5 of table
In above-described embodiment, embodiment 3 is most preferred embodiment.
The compound preparation of the present invention of embodiment 6 is used for the test of pet postoperative rehabilitation
The compound preparation of embodiment 3 is selected, following tests is carried out:
Pet test site: pet dog breeding farm Weifang A(), pet dog breeding farm Weifang B() and the Weifang pet clinic C(), dote on The Qingdao object hospital D(), add up to four part test places.
Operational staff: 4 practising veterinarians are worked at a selected spot and are tested, and collect record test data, test before practising veterinarian into Row routine inspection, and recorded.
Sample: this test is related to case 280, wherein farm's kind of dog 6, outpatient service kind of dog 12, across the gestational period, Childhood, teenage, adult, aged 5 stages；Random experiment is taken, and sets up blank control or product control, according to batheroom scale It calculates dosage to be taken orally, observes and records result.
Medication: oral, therapeutic dose, adult dogs cat take 1 time daily, and 1 bottle every time, five days as a treatment course.Weight Lower than 2 kilograms each taking half bottle；10 kilograms of weight or more pet dosages double (i.e. 2 bottles/time), voluntarily lick, can also admix Fed diets.Specification: 5g/ bottles.
Test result is as follows:
(1) small sample test data: (dog breeding farm) gold hair, safe each 20 of enlightening (test+control), the above test dog sample standard deviation reach It is required to operation.All dogs of experiment are participated in cut at abdomen left or right side (random) by operation requirement one 4cm length skin of work Mouthful.
Healing effect of the compound preparation of the present invention of table 2 to operative incision
Note: setting two groups of test groups and two groups of control groups, and test group is the product using the embodiment of the present invention 3, and control group is blank Control.
Interpretation of result: since cultivation scale and sample size are limited but still very convincing to effect of the invention, Product of the present invention can accelerating wound healing, hence it is evident that shortens healing cycle.After test group medication, the wound after first course for the treatment of 5 days It can heal completely, poor wound healing then occurs in control group, and control group 1 still has half not heal after second course for the treatment of Dog；Control group 2 also still has 2 dogs not heal.The result shows that test group is obvious using therapeutic effect after product of the present invention, healing Time greatly shortens, and reaches expected.
Note: whole pathology wound models, preoperative and postoperative is strictly by operation requirement processing.
(2) similar product comparative test
The Contrast on effect of table 3 compound preparation of the present invention and existing product
Note: test group and control group respectively set 4 groups, and test group sets 3-6 group as using product of the present invention, control group 3-6 is used respectively Test unit (pet breeding farm and pet clinic) is at present with product.
Data record analysis: from the point of view of test result analysis, in terms of first course of therapy effect, then product of the present invention Therapeutic effect is more excellent.Two groups of farm wounds healing rate such as bite, scratch is 100% and 95% respectively, is higher by control group respectively 15 and 20 percentage points.Two groups of pets hospital are respectively 75.0% and 77.5%, are higher by 32 percentage points of control group, difference is aobvious It writes, it can be seen that the present invention can be such that treatment cycle is obviously shortened, and improve healing rate.
4 the 2nd course for the treatment of healing rates of test group are 95% or more；4 groups of control groups are after second course for the treatment of, treatment effect Fruit is also 90% or more.
Above-described embodiment is all to be conceived using this and actually made for illustrating inventive concept and actual use of the invention With making a non-material change to the present invention, protection scope of the present invention should all be fallen into.

Claims (7)

1. a kind of compound preparation for pet postoperative rehabilitation, it is characterised in that: the compound preparation, including following raw material group Point: Csad albumen, saccharicter-penin, Co-Q10, oligofructose, pseudo-ginseng, drying powder, DEXTROSE ANHYDROUS.
2. a kind of compound preparation for pet postoperative rehabilitation according to claim 1, it is characterised in that: the compound system Agent, in parts by weight, including following raw material components: Csad albumen: 0.10-0.30 parts；Saccharicter-penin: 0.60-2.2 parts；Coenzyme Q10:0.02-0.12 parts；Oligofructose: 0.60-1.4 parts；Pseudo-ginseng: 0.60-1.4 parts；Drying powder: 0.10 part；DEXTROSE ANHYDROUS Add to 20 parts.
3. a kind of compound preparation for pet postoperative rehabilitation according to claim 1, it is characterised in that: the compound system Agent, in parts by weight, including following raw material components: Csad albumen: 0.20 part；Saccharicter-penin: 1.4 parts；Co-Q10: 0.06 part； Oligofructose: 1.0 parts；Pseudo-ginseng: 1.0 parts；DEXTROSE ANHYDROUS: 16.24 parts；Drying powder: 0.10 part.
4. a kind of compound preparation for pet postoperative rehabilitation according to claim 1, it is characterised in that: the compound system Agent, in parts by weight, including following raw material components: Csad albumen: 0.10 part；Saccharicter-penin: 0.60 part；Co-Q10: 0.02 part； Oligofructose: 0.60 part；Pseudo-ginseng: 0.60 part；DEXTROSE ANHYDROUS: 17.98 parts；Drying powder: 0.10 part.
5. a kind of compound preparation for pet postoperative rehabilitation according to claim 1, it is characterised in that: the compound system Agent, in parts by weight, including following raw material components: Csad albumen: 0.15 part；Saccharicter-penin: 1.0 parts；Co-Q10: 0.04 part；It is low Fructooligosaccharides: 0.80 part；Pseudo-ginseng: 0.80 part；DEXTROSE ANHYDROUS: 17.11 parts；Drying powder: 0.10 part.
6. a kind of compound preparation for pet postoperative rehabilitation according to claim 1, it is characterised in that: the compound system Agent, in parts by weight, including following raw material components: Csad albumen: 0.25 part；Saccharicter-penin: 1.8 parts；Co-Q10: 0.08 part；It is low Fructooligosaccharides: 1.2 parts；Pseudo-ginseng: 1.2 parts；DEXTROSE ANHYDROUS: 15.37 parts；Drying powder: 0.10 part.
7. a kind of compound preparation for pet postoperative rehabilitation according to claim 1, it is characterised in that: the compound system Agent, in parts by weight, including following raw material components: Csad albumen: 0.30 part；Saccharicter-penin: 2.2 parts；Co-Q10: 0.12 part； Oligofructose: 1.4 parts；Pseudo-ginseng: 1.4 parts；DEXTROSE ANHYDROUS: 14.48 parts；Drying powder: 0.10 part.
CN201811027962.0A 2018-09-04 2018-09-04 A kind of compound preparation for pet postoperative rehabilitation Withdrawn CN109157655A (en)

Priority Applications (1)

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CN201811027962.0A CN109157655A (en) 2018-09-04 2018-09-04 A kind of compound preparation for pet postoperative rehabilitation

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Application Number Priority Date Filing Date Title
CN201811027962.0A CN109157655A (en) 2018-09-04 2018-09-04 A kind of compound preparation for pet postoperative rehabilitation

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CN109157655A true CN109157655A (en) 2019-01-08

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Country Status (1)

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Application publication date: 20190108