CN108852909A - A kind of anti-caries toothpaste and preparation method thereof - Google Patents
A kind of anti-caries toothpaste and preparation method thereof Download PDFInfo
- Publication number
- CN108852909A CN108852909A CN201810864891.3A CN201810864891A CN108852909A CN 108852909 A CN108852909 A CN 108852909A CN 201810864891 A CN201810864891 A CN 201810864891A CN 108852909 A CN108852909 A CN 108852909A
- Authority
- CN
- China
- Prior art keywords
- caries
- toothpaste
- added
- sodium
- chitosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention relates to a kind of anti-caries toothpaste and preparation method thereof, belong to technical field of toothpaste.The present invention is added to papaya seed volatile oil and chitosan simultaneously, and two mutual compatibilities of component play the synergistic effect for promoting anti-caries effect mutually, meanwhile, it had both solved the problems, such as that chitosan was difficult to dissolve, and had also improved the stability of papaya seed volatile oil.The toothpaste performance is stablized, and has pure and fresh ice-cold mouthfeel, improves implication, can effective pre- anti-caries.
Description
Technical field
The present invention relates to a kind of anti-caries toothpaste and preparation method thereof, belong to skin care technical field.
Background technique
Dental caries are a kind of mouth diseases of common multiple factors in combination effect, and years of researches are it has been proved that variation
Streptococcus (Streptococcus mutans) is to lead to the main cariogenic bacteria of the mankind, its Cariogenicity is mainly manifested in facing
Stick, settle down, produce acid and acid resistance, and it sticks in facing, assembles that form the process of plaque biofilm be its cause
The basis of dental caries, therefore, the formation of control plaque biofilm are the key that prevention and control dental caries.It is existing the study found that
The active force for having the bacterium of biofilm to resist antibiotic wants high 1000 times of the bacterium of specific ionization state or more, and is difficult to common
Sterilization method removed.Plant volatile oil is also known as essential oil, has anti-oxidant, antiviral, the multiple biological activities such as antibacterial, kind
The main component of pawpaw seed volatile oil is benzyl isothiocyanate (Benzyl isothiocyanate, BITC), accounts for 99.36%.It is different
Research of the benzyl thiocyanate in terms of anti-cancer, suppression cancer makes great progress, and has very strong bioactivity, and is inhibiting
The research of oral bacteria growth aspect has not been reported.
Summary of the invention
In view of the above-mentioned problems, being volatilized the purpose of the present invention is to provide a kind of anti-caries toothpaste by using papaya seed
Oil and two mutual compatibilities of component of chitosan play the synergistic effect for promoting anti-caries effect mutually, meanwhile, both solve shell
Glycan is difficult to the problem dissolved, also improves the stability of papaya seed volatile oil.The toothpaste performance is stablized, and has pure and fresh ice-cold
Mouthfeel improves implication, can effective pre- anti-caries.
Technical solution of the invention is：
A kind of anti-caries toothpaste, is formulated by the raw material containing following weight ratio：Papaya seed volatile oil 0.004%~
0.008%, chitosan 0.846%~1.272%, calcium bicarbonate 35%~45%, glycerol 0.60%~1.50%, sorbierite
18%~20%, sodium carboxymethylcellulose 0.50%~1.00%, sldium lauryl sulfate 2.00%~4.00%, sodium alginate
0.14%~0.20%, Sodium Hyaluronate 3.50%~4.80%, methyl p-hydroxybenzoate 0.10%~0.20%, xylitol
0.01%~0.02%, deionized water 22%~39.3%.
Further, the papaya seed volatile oil is extracted by papaya seed, wherein benzyl isothiocyanate
Content be 99.36%.
The extracting method referenced patent application 20141018682.
Further, the content of the chitosan is 99%, and pH value is 5~6.
Further, the content of the calcium bicarbonate is 99%, and granularity is 80 mesh.
Further, the content of the Sodium Hyaluronate is that 95%, Chong Jin belongs to Han Liang≤10ppm.
The present invention also provides a kind of preparation methods of anti-caries toothpaste, comprise the following steps：
Firstly, 22%~39.3% deionized water is taken to be put into reaction kettle, open blender, set mixing speed as
35%~45% sodium bicarbonate and 18%~20% sorbierite is successively added in 50rpm, after all dissolutions, improves stirring
Speed to 80rpm, then successively take 0.60%~1.50% glycerol, 0.50%~1.00% sodium carboxymethylcellulose,
0.14%~0.20% sodium alginate and 0.10%~0.20% methyl p-hydroxybenzoate be added reaction kettle in, keep stirring
30min is mixed, premix decentralized processing is carried out；
Then, heating device is opened, set temperature is 70~85 DEG C, successively it is slowly added 0.004% into reaction kettle~
0.008% papaya seed volatile oil, 0.846%~1.272% chitosan, 3.50%~4.80% Sodium Hyaluronate,
It has added and has continued to stir 1h, then kept the temperature 30min, it is ensured that stirred evenly；
Finally, reduce mixing speed to 30rpm, it is added 0.01%~0.02% xylitol, 2.00%~4.00%
Sldium lauryl sulfate continues to stir 1h, closes heating device and agitating device, is slowly dropped to room temperature, stands 1h, discharging.
Papaya seed volatile oil plays the role of good anti-caries in this programme, this is in the current prior art and text
It is not all disclosed and disclosed in offering.In addition, chitosan has the function of good inhibition bacterial activity, it has been applied to make up
Product, agricultural, Field of Tobacco, but the problem of because of chitosan indissoluble, it can not be applied in toothpaste well always, individual technologies
In have and add water soluble chitosan by the way of modified and be added in toothpaste, but its antibacterial effect can decline to a great extent.The present invention is logical
It crosses papaya seed volatile oil and chitosan is used in combination, both discoveries have the effect that mixes, and reasonable ratio of finally arranging in pairs or groups is perfect
The problem of overcoming chitosan indissoluble, chitosan also ensure the stability of papaya seed volatile oil in toothpaste composition.
The performance comparison of the anti-caries toothpaste of the present invention of table 1 and other class anti-caries toothpaste or drug
| Anti-caries toothpaste 1 | Anti-caries toothpaste 2 | Anti-caries toothpaste of the present invention | Anti-caries drug | |
| Appearance | Milky has light damp | Milky | Milky has light damp | / |
| Mouthfeel | It is pure and fresh, fragrant and sweet | It is pure and fresh, fragrant and sweet | It is pure and fresh, fragrant and sweet | / |
| Anti-caries effect | 90.5%~94.2% | 66.5%~70.6% | 93.2%~95.4% | 95.0%~96.3% |
| Stability | It is layered after 1 month | It is layered after 15 days | 1 year not stratified | / |
Remarks：1. anti-caries toothpaste 1, anti-caries toothpaste 2 are respectively to remove kind wood in anti-caries formulation of tooth-paste of the present invention
After melon seeds volatile oil, chitosan, still maintain and toothpaste made of same amount ratio of the present invention and identical preparation process；
2. anti-caries drug is chlorhexidine, drug effect and above-mentioned 3 toothpaste are compared in conventional use scope；
3. anticaries tooth effect by under equal ambient to the inhibiting rate percentage of the Streptococcus mutans of laboratory cultures come table
Sign.
For reference table 1 it is found that the toothpaste 1 that individually addition papaya seed volatile oil makes, anti-caries effect is also relatively obvious,
But stability is poor, and mutually lamination occur to the oil such as papaya seed volatile oil and glycerol in other water phase components with toothpaste after 1 month,
Stability is undesirable；If do not added papaya seed volatile oil, toothpaste 2 made of chitosan is only added, part is also played
Anti-caries effect, but only 66.5%~70.6% more only adds papaya seed volatile oil decline 40%, analyzed only deposit it is anti-
Saprodontia effect is provided by xylitol, chitosan, while the toothpaste, after 15 days there have been oil reservoir layering, stability is worse.
For opposite toothpaste 1 and toothpaste 2, square saprodontia toothpaste of the invention is prevented because being added to papaya seed volatile oil and chitosan simultaneously
Saprodontia effect is higher than the anti-caries effect generated when two components are used alone, and stability is promoted to 1 year or more.Thus may be used
Knowing, in the present invention program, the mutual compatibility of above-mentioned two component plays synergistic synergistic effect, meanwhile, both solved
Chitosan is difficult to the problem dissolved, also improves the stability of papaya seed volatile oil.In addition, due to being added to hyaluronic acid
Sodium, manufactured tooth paste product is especially pure and fresh palatable, and the children of different age group and adult is suitble to use.In conjunction with reasonable selection
The components such as other rubbing agents, manufactured anti-caries toothpaste, stability can achieve 1 year or more, day frequently as health care product come using,
The drug effect that the anti-caries effect played basically reaches anti-caries drug is horizontal.
Specific embodiment
For the technological means and beneficial effect that the present invention is further explained, in conjunction with the preferred embodiment, to of the invention
Embodiment is described in detail：
Embodiment one
Firstly, 39.3% deionized water is taken to be put into reaction kettle, blender is opened, sets mixing speed as 50rpm, first
35% sodium bicarbonate and 18% sorbierite are added afterwards, after all dissolutions, raising mixing speed to 80rpm, then successively take
0.60% glycerol, 0.50% sodium carboxymethylcellulose, 0.14% sodium alginate and 0.10% P-hydroxybenzoic acid first
Ester is added in reaction kettle, is kept stirring 30min, carries out premix decentralized processing；
Then, heating device is opened, set temperature is 70 DEG C, and 0.004% kind wood is successively slowly added into reaction kettle
Melon seeds volatile oil, 0.846% chitosan, 3.50% Sodium Hyaluronate have added and have continued to stir 1h, then kept the temperature 30min, really
Guarantor stirs evenly；
Finally, reducing mixing speed to 30rpm, 0.01% xylitol is added, 2.00% sldium lauryl sulfate continues
1h is stirred, heating device and agitating device are closed, is slowly dropped to room temperature, stands 1h, anti-caries toothpaste is made in discharging.
After tested, the anti-caries effect of the toothpaste reaches 93.5%, and stability can be kept 1 year or more.
Embodiment two
Firstly, 33.55% deionized water is taken to be put into reaction kettle, blender is opened, sets mixing speed as 50rpm,
38% sodium bicarbonate and 19% sorbierite is successively added, after all dissolutions, raising mixing speed to 80rpm, then successively
Take 0.80% glycerol, 0.60% sodium carboxymethylcellulose, 0.16% sodium alginate and 0.20% P-hydroxybenzoic acid
Methyl esters is added in reaction kettle, is kept stirring 30min, carries out premix decentralized processing；
Then, heating device is opened, set temperature is 78 DEG C, and 0.006% kind wood is successively slowly added into reaction kettle
Melon seeds volatile oil, 0.864% chitosan, 3.80% Sodium Hyaluronate have added and have continued to stir 1h, then kept the temperature 30min, really
Guarantor stirs evenly；
Finally, reducing mixing speed to 30rpm, 0.02% xylitol is added, 3.00% sldium lauryl sulfate continues
1h is stirred, heating device and agitating device are closed, is slowly dropped to room temperature, stands 1h, discharging.
After tested, the anti-caries effect of the toothpaste reaches 93.2%, and stability can be kept 1 year or more.
Embodiment three
Firstly, 31.04% deionized water is taken to be put into reaction kettle, blender is opened, sets mixing speed as 50rpm,
40% sodium bicarbonate and 18% sorbierite is successively added, after all dissolutions, raising mixing speed to 80rpm, then successively
Take 1.00% glycerol, 0.70% sodium carboxymethylcellulose, 0.18% sodium alginate and 0.10% P-hydroxybenzoic acid
Methyl esters is added in reaction kettle, is kept stirring 30min, carries out premix decentralized processing；
Then, heating device is opened, set temperature is 75 DEG C, and 0.007% kind wood is successively slowly added into reaction kettle
Melon seeds volatile oil, 0.963% chitosan, 4.00% Sodium Hyaluronate have added and have continued to stir 1h, then kept the temperature 30min, really
Guarantor stirs evenly；
Finally, reducing mixing speed to 30rpm, 0.01% xylitol is added, 4.00% sldium lauryl sulfate continues
1h is stirred, heating device and agitating device are closed, is slowly dropped to room temperature, stands 1h, discharging.
After tested, the anti-caries effect of the toothpaste reaches 94.6%, and stability can be kept 1 year or more.
Example IV
Firstly, 28.02% deionized water is taken to be put into reaction kettle, blender is opened, sets mixing speed as 50rpm,
42% sodium bicarbonate and 19% sorbierite is successively added, after all dissolutions, raising mixing speed to 80rpm, then successively
Take 1.20% glycerol, 0.80% sodium carboxymethylcellulose, 0.15% sodium alginate and 0.20% P-hydroxybenzoic acid
Methyl esters is added in reaction kettle, is kept stirring 30min, carries out premix decentralized processing；
Then, heating device is opened, set temperature is 80 DEG C, and 0.008% kind wood is successively slowly added into reaction kettle
Melon seeds volatile oil, 1.112% chitosan, 4.50% Sodium Hyaluronate have added and have continued to stir 1h, then kept the temperature 30min, really
Guarantor stirs evenly；
Finally, reducing mixing speed to 30rpm, 0.01% xylitol is added, 3.00% sldium lauryl sulfate continues
1h is stirred, heating device and agitating device are closed, is slowly dropped to room temperature, stands 1h, discharging.
After tested, the anti-caries effect of the toothpaste reaches 94.9%, and stability can be kept 1 year or more.
Embodiment five
Firstly, 22% deionized water is taken to be put into reaction kettle, blender is opened, sets mixing speed as 50rpm, successively
45% sodium bicarbonate and 20% sorbierite is added, after all dissolutions, raising mixing speed to 80rpm, then successively take
1.50% glycerol, 1.00% sodium carboxymethylcellulose, 0.20% sodium alginate and 0.20% P-hydroxybenzoic acid first
Ester is added in reaction kettle, is kept stirring 30min, carries out premix decentralized processing；
Then, heating device is opened, set temperature is 85 DEG C, and 0.008% kind wood is successively slowly added into reaction kettle
Melon seeds volatile oil, 1.272% chitosan, 4.80% Sodium Hyaluronate have added and have continued to stir 1h, then kept the temperature 30min, really
Guarantor stirs evenly；
Finally, reducing mixing speed to 30rpm, 0.02% xylitol is added, 4.00% sldium lauryl sulfate continues
1h is stirred, heating device and agitating device are closed, is slowly dropped to room temperature, stands 1h, discharging.
After tested, the anti-caries effect of the toothpaste reaches 95.4%, and stability can be kept 1 year or more.
Claims (6)
1. a kind of anti-caries toothpaste, which is characterized in that be formulated by the raw material containing following weight ratio：Papaya seed volatile oil
0.004%~0.008%, chitosan 0.846%~1.272%, calcium bicarbonate 35%~45%, glycerol 0.60%~
1.50%, sorbierite 18%~20%, sodium carboxymethylcellulose 0.50%~1.00%, sldium lauryl sulfate 2.00%~
4.00%, sodium alginate 0.14%~0.20%, Sodium Hyaluronate 3.50%~4.80%, methyl p-hydroxybenzoate 0.10%
~0.20%, xylitol 0.01%~0.02%, deionized water 22%~39.3%.
2. a kind of anti-caries toothpaste as described in claim 1, which is characterized in that the papaya seed volatile oil be by kind
Pawpaw seeds are extracted and are obtained, wherein the content of benzyl isothiocyanate is 99.36%.
3. a kind of anti-caries toothpaste as described in claim 1, which is characterized in that the content of the chitosan is 99%, pH
Value is 5~6.
4. a kind of anti-caries toothpaste as described in claim 1, which is characterized in that the content of the calcium bicarbonate is 99%,
Granularity is 80 mesh.
5. a kind of anti-caries toothpaste as described in claim 1, which is characterized in that the content of the Sodium Hyaluronate is
95%, Chong Jin belong to Han Liang≤10ppm.
6. a kind of preparation method of anti-caries toothpaste as described in claim 1, which is characterized in that comprise the following steps：
Firstly, 22%~39.3% deionized water is taken to be put into reaction kettle, blender is opened, sets mixing speed as 50rpm,
35%~45% sodium bicarbonate and 18%~20% sorbierite is successively added, after all dissolutions, improves mixing speed extremely
80rpm, then successively take 0.60%~1.50% glycerol, 0.50%~1.00% sodium carboxymethylcellulose, 0.14%~
0.20% sodium alginate and 0.10%~0.20% methyl p-hydroxybenzoate be added reaction kettle in, be kept stirring 30min,
Carry out premix decentralized processing；
Then, heating device is opened, set temperature is 70~85 DEG C, successively it is slowly added 0.004% into reaction kettle~
0.008% papaya seed volatile oil, 0.846%~1.272% chitosan, 3.50%~4.80% Sodium Hyaluronate,
It has added and has continued to stir 1h, then kept the temperature 30min, it is ensured that stirred evenly；
Finally, reducing mixing speed to 30rpm, 0.01%~0.02% xylitol, 2.00%~4.00% laurel is added
Alcohol sodium sulphate continues to stir 1h, closes heating device and agitating device, is slowly dropped to room temperature, stands 1h, discharging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810864891.3A CN108852909B (en) | 2018-08-01 | 2018-08-01 | Toothpaste for preventing dental caries and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810864891.3A CN108852909B (en) | 2018-08-01 | 2018-08-01 | Toothpaste for preventing dental caries and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108852909A true CN108852909A (en) | 2018-11-23 |
| CN108852909B CN108852909B (en) | 2021-11-23 |
Family
ID=64307181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810864891.3A Active CN108852909B (en) | 2018-08-01 | 2018-08-01 | Toothpaste for preventing dental caries and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108852909B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114469759A (en) * | 2022-02-14 | 2022-05-13 | 西安医学院 | Toothpaste for preventing dental caries and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5929618A (en) * | 1982-08-11 | 1984-02-16 | T Hasegawa Co Ltd | Preventing agent for carious tooth |
| JP2005104856A (en) * | 2003-09-29 | 2005-04-21 | Ogawa & Co Ltd | Dental plaque formation inhibitor composition, and food and drink or oral hygienic agent containing the composition |
| WO2007132807A1 (en) * | 2006-05-16 | 2007-11-22 | Ogawa & Co., Ltd. | Antiperiodontitis agents, and drinks, foods or oral hygiene products containing the agents |
| JP2008174542A (en) * | 2006-12-18 | 2008-07-31 | Lion Corp | Oral composition |
| CN103717225A (en) * | 2011-07-26 | 2014-04-09 | Wm.雷格利Jr.公司 | Compositions containing zinc salts and isothiocyanates for reduction of oral volatile sulfur compounds (vscs) |
| CN103951598A (en) * | 2014-05-06 | 2014-07-30 | 中国热带农业科学院椰子研究所 | Method for extracting benzyl isothiocyanate from papaya seeds |
| CN104688789A (en) * | 2015-02-12 | 2015-06-10 | 领思科技(大连)有限公司 | Papaya seed extract sustained-release preparation and application thereof |
| CN105192057A (en) * | 2015-09-21 | 2015-12-30 | 杨凌农科大无公害农药研究服务中心 | Application of athomin to fruit and vegetable freshness preservation |
| CN106491406A (en) * | 2016-12-25 | 2017-03-15 | 江西宜信堂医疗科技有限公司 | A kind of inhibiting bacteria and diminishing inflammation toothpaste and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5929618B2 (en) * | 2012-08-10 | 2016-06-08 | トヨタ自動車株式会社 | Resolver stator |
-
2018
- 2018-08-01 CN CN201810864891.3A patent/CN108852909B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5929618A (en) * | 1982-08-11 | 1984-02-16 | T Hasegawa Co Ltd | Preventing agent for carious tooth |
| JP2005104856A (en) * | 2003-09-29 | 2005-04-21 | Ogawa & Co Ltd | Dental plaque formation inhibitor composition, and food and drink or oral hygienic agent containing the composition |
| WO2007132807A1 (en) * | 2006-05-16 | 2007-11-22 | Ogawa & Co., Ltd. | Antiperiodontitis agents, and drinks, foods or oral hygiene products containing the agents |
| JP2008174542A (en) * | 2006-12-18 | 2008-07-31 | Lion Corp | Oral composition |
| CN103717225A (en) * | 2011-07-26 | 2014-04-09 | Wm.雷格利Jr.公司 | Compositions containing zinc salts and isothiocyanates for reduction of oral volatile sulfur compounds (vscs) |
| CN103951598A (en) * | 2014-05-06 | 2014-07-30 | 中国热带农业科学院椰子研究所 | Method for extracting benzyl isothiocyanate from papaya seeds |
| CN104688789A (en) * | 2015-02-12 | 2015-06-10 | 领思科技(大连)有限公司 | Papaya seed extract sustained-release preparation and application thereof |
| CN105192057A (en) * | 2015-09-21 | 2015-12-30 | 杨凌农科大无公害农药研究服务中心 | Application of athomin to fruit and vegetable freshness preservation |
| CN106491406A (en) * | 2016-12-25 | 2017-03-15 | 江西宜信堂医疗科技有限公司 | A kind of inhibiting bacteria and diminishing inflammation toothpaste and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| SHIVANI UPPAL等: "Chitosan nanoparticles as a biocompatible and efficient nanowagon for benzyl isothiocyanate", 《INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES》 * |
| 国家医药管理局中草药情报中心站: "《植物药有效成分手册》", 31 March 1986, 人民卫生出版社 * |
| 应泽茜等: "海南产番木瓜籽挥发油的稳定性及抗假丝酵母菌活性的研究", 《时珍国医国药》 * |
| 邓福明等: "木瓜籽精油的提取及其抗氧化活性研究", 《热带农业科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114469759A (en) * | 2022-02-14 | 2022-05-13 | 西安医学院 | Toothpaste for preventing dental caries and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108852909B (en) | 2021-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101926741B (en) | Skin refinishing essence and skin care product with same | |
| CN104435379B (en) | A kind of plant extract complex with antibacterial anti-inflammatory, hemostasis and pain relieving and application thereof | |
| CN106176556A (en) | A kind of removing acnes and controlling oil whitening cream | |
| GB2472379A (en) | Topical cosmetic formulation comprising MSM, a vitamin and a carbohydrate | |
| KR100747651B1 (en) | Material compositions for hair health care and hair growth acceleration | |
| CN112691057B (en) | Compound efficacy toothpaste and preparation method thereof | |
| CN108451814A (en) | A kind of infantile eczema skin care item and preparation method thereof | |
| CN103417456A (en) | Preparing method for propolis and pollen compound massage cream | |
| CN108852909A (en) | A kind of anti-caries toothpaste and preparation method thereof | |
| CN108324661B (en) | Beta-cyclodextrin-based antibacterial anti-inflammatory and halitosis-removing mouth wash and preparation method thereof | |
| KR101274811B1 (en) | Potent anti-acne composition containing perilla frutescens and/or lygodium japonicum extract | |
| CN113384502A (en) | Moisturizing emulsion and preparation method thereof | |
| KR20070058782A (en) | Natural sap and its production methods | |
| CN102335111B (en) | Powder toothpaste combination comprising Ag particles and manufacturing method thereof | |
| KR20130001989A (en) | Mouthwash composition | |
| CN103599182A (en) | Traditional Chinese medicine composition and preparation method thereof, and oral cavity cleaning and nursing product and preparation method thereof | |
| WO2013078754A1 (en) | Promoting hair growth solution containing chlorine dioxide， preparation method and use method thereof | |
| CN106474137B (en) | A kind of film for treating oral ulcer containing chlorophyll and preparation method thereof | |
| Kumar et al. | In vitro morphogenesis of Aloe vera: the “medicinal wonder” plant | |
| KR101637194B1 (en) | Make-up soap composition containing medicinal herbs extract, amino acid complex and manufacturing method thereof | |
| CN104738299A (en) | Preparation method of radix cynanchi bungei honey slice and product prepared by method | |
| DE60102142T2 (en) | COSMETIC USE OF HOP AND ORNITHIN | |
| CN110507580A (en) | A kind of toothpaste of the ingredient containing trollflower and preparation method thereof | |
| CN108888560A (en) | A kind of natural eyelash growing liquid preparation method | |
| CN109793757A (en) | A kind of composition and its preparation method and application inhibiting cicatrix of skin growth |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |