CN108836958A - A kind of compound salbutamol sulfate capsule suitable for refractory asthma - Google Patents
A kind of compound salbutamol sulfate capsule suitable for refractory asthma Download PDFInfo
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- CN108836958A CN108836958A CN201811111879.1A CN201811111879A CN108836958A CN 108836958 A CN108836958 A CN 108836958A CN 201811111879 A CN201811111879 A CN 201811111879A CN 108836958 A CN108836958 A CN 108836958A
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- salbutamol sulfate
- refractory asthma
- blueberry anthocyanin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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Abstract
The invention discloses a kind of compound salbutamol sulfate capsule suitable for refractory asthma, effective component is：Salbutamol sulfate and beclomeasone propionate；Wherein salbutamol sulfate is to be suitable for bronchial asthma, asthma type brochitis and pulmonary emphysema etc., can alleviate breaking-out；And the potent external application glucocorticoids medicine of beclomeasone propionate system, have the effects that anti-inflammatory, antiallergy and antipruritic, bronchus exudate can be inhibited, eliminate tunica mucosa bronchiorum swelling, releases bronchial spasm；The two is used in combination, better effect.The present invention joined blueberry anthocyanin on the basis of conventional formulation, and main function is the drug resistance that patient can be effectively reduced to the capsule, and blueberry anthocyanin is extremely easy in decomposition, and superelevation Gel baits albumen powder is added can be with effective protection blueberry anthocyanin.
Description
Technical field
The present invention relates to biopharmaceutical technology more particularly to a kind of sulfated compound sand fourths suitable for refractory asthma
Amine alcohol capsule.
Background technique
Refractory asthma refers to treatment of the asthmatic patient Jing Guo a variety of methods and drug, it is difficult to reach control disease development
Situation, this it is clinical be also the key points and difficulties that more common and curative activity is captured.It is generally believed that steroids
Drug therapy has certain effect, but because the reason of inducing asthma is complicated, unstable condition, so the often sugared cortex of application
Hormone etc. can cause drug resistance, the benefit not excessive to treatment.
The present invention provides a kind of compound salbutamol sulfate capsule for refractory asthma, efficiently solves drug resistance and asks
Topic.
Summary of the invention
Technical problems based on background technology, the invention proposes a kind of sulfated compounds suitable for refractory asthma
Salbutamol capsule.
Technical scheme is as follows：
A kind of compound salbutamol sulfate capsule suitable for refractory asthma, effective component are：Salbutamol sulfate and third
Sour beclomethasone.
Preferably, effective component further includes blueberry anthocyanin.
Preferably, the compound salbutamol sulfate capsule suitable for refractory asthma, including following parts by weight
Ingredient：200-500 parts of low-substituted hydroxypropyl cellulose, 60-80 parts of crospovidone, 8-15 parts of blueberry anthocyanin, superelevation gel
Albumen powder 40-60 part of degree, 10-20 parts of lauryl sodium sulfate, 15-20 parts of magnesium stearate, 3-6 parts of salbutamol sulfate and third
1 part of sour beclomethasone.
Preferably, the extracting method of the blueberry anthocyanin, includes the following steps：Fresh blueberry is protected from light at 4-8 DEG C
Under the conditions of use volume fraction for 2-5% citric acid ethanol solution extract 16-20h；Extracting solution is through centrifugation, ultra-filtration and separation, chromatography
The processing such as purifying, vacuum freeze drying, can be obtained the blueberry anthocyanin of high-purity.
Preferably, the primary raw material of the superelevation Gel baits albumen powder is egg.
Preferably, the Gel baits intensity of the superelevation Gel baits albumen powder is 1200-1600g/cm2。
Salbutamol sulfate is suitable for bronchial asthma, asthma type brochitis and pulmonary emphysema etc., alleviates the multi-purpose gas that breaks out
Mist sucking, and the then Orally-administrable that prevents attacks.
The potent external application glucocorticoids medicine of beclomeasone propionate system has the effects that anti-inflammatory, antiallergy and antipruritic, can press down
Bronchus exudate processed eliminates tunica mucosa bronchiorum swelling, releases bronchial spasm.It can more than hydrogenation to skin vasoconstriction effect
Pine it is strong.Local anti-inflammatory effect is 5 times of fluocinolone acetonide and triamcinolone.Lipophilicity is stronger, easily permeates, and is applied to affected part after 30 minutes i.e.
It comes into force.
Anthocyanidin (anthocyanidins), also known as anthocyanidin, it is water-soluble in plant to be that nature one kind is widely present in
Property natural pigment, be that coloured back obtained by anthocyanin (anthocyains) hydrolysis is first.Master in water fruits and vegetables, flowers
Want present-color material largely associated therewith.Under the conditions of plant cell vacuole different PH value, anthocyanidin makes petal that the five colours be presented
In riotous profusion color.More than 20 kinds of known anthocyanidin, it is important in food to have 6 kinds, i.e. pelargonidin, cyanidin, delphinium
Pigment, paeonidin, morning glory pigment and malvidin.The anthocyanidin of nature all exists with glycoside forms, referred to as pattern
Glycosides, few free anthocyanidin exist.In terms of anthocyanidin is mainly used for food color, it can also be used to dyestuff, medicine, cosmetics
Etc.；Blueberry anthocyanin（Vaccinium Oxycoccus Pigment）It is reddish brown to black for the derivative of flavones and flavanones
Brown powder, bulk or liquid, slightly flavour.It is slightly soluble in water.By thermally labile.
The invention has the beneficial effects that：
Compound salbutamol sulfate capsule suitable for refractory asthma of the invention, effective component are：Salbutamol sulfate
And beclomeasone propionate；Wherein salbutamol sulfate is to be suitable for bronchial asthma, asthma type brochitis and pulmonary emphysema etc., can
To alleviate breaking-out；And the potent external application glucocorticoids medicine of beclomeasone propionate system, there is anti-inflammatory, antiallergy and antipruritic etc. make
With can inhibit bronchus exudate, eliminate tunica mucosa bronchiorum swelling, release bronchial spasm；The two is used in combination, and effect is more
It is good.The present invention joined blueberry anthocyanin on the basis of conventional formulation, and main function is that patient can be effectively reduced to the glue
The drug resistance of capsule, and blueberry anthocyanin is extremely easy in decomposition, superelevation Gel baits albumen powder is added can be with effective protection blueberry anthocyanin.
Specific embodiment
Embodiment 1：
A kind of compound salbutamol sulfate capsule suitable for refractory asthma, the ingredient including following parts by weight：Low substitution hydroxyl
350 parts of propyl cellulose, 70 parts of crospovidone, 12 parts of blueberry anthocyanin, 55 parts of superelevation Gel baits albumen powder, dodecyl
15 parts of sodium sulphate, 18 parts of magnesium stearate, 5 parts and 1 part of beclomeasone propionate of salbutamol sulfate.
The extracting method of the blueberry anthocyanin, includes the following steps：Fresh blueberry is adopted under the conditions of being protected from light for 4-8 DEG C
18h is extracted with the citric acid ethanol solution that volume fraction is 2.5%；Extracting solution is cold through centrifugation, ultra-filtration and separation, chromatographic purifying, vacuum
Dry equal processing is lyophilized, the blueberry anthocyanin of high-purity can be obtained.
The primary raw material of the superelevation Gel baits albumen powder is egg；The Gel baits of the superelevation Gel baits albumen powder
Intensity is 1450g/cm2。
Embodiment 2：
A kind of compound salbutamol sulfate capsule suitable for refractory asthma, the ingredient including following parts by weight：Low substitution hydroxyl
500 parts of propyl cellulose, 60 parts of crospovidone, 15 parts of blueberry anthocyanin, 40 parts of superelevation Gel baits albumen powder, dodecyl
20 parts of sodium sulphate, 15 parts of magnesium stearate, 6 parts and 1 part of beclomeasone propionate of salbutamol sulfate.
The extracting method of the blueberry anthocyanin, includes the following steps：Fresh blueberry is adopted under the conditions of being protected from light for 4-8 DEG C
20h is extracted with the citric acid ethanol solution that volume fraction is 2%；Extracting solution is through centrifugation, ultra-filtration and separation, chromatographic purifying, vacuum refrigeration
The processing such as dry, can be obtained the blueberry anthocyanin of high-purity.
The primary raw material of the superelevation Gel baits albumen powder is egg；The Gel baits of the superelevation Gel baits albumen powder
Intensity is 1200g/cm2。
Embodiment 3：
A kind of compound salbutamol sulfate capsule suitable for refractory asthma, the ingredient including following parts by weight：Low substitution hydroxyl
200 parts of propyl cellulose, 80 parts of crospovidone, 8 parts of blueberry anthocyanin, 60 parts of superelevation Gel baits albumen powder, dodecyl
10 parts of sodium sulphate, 20 parts of magnesium stearate, 3 parts and 1 part of beclomeasone propionate of salbutamol sulfate.
The extracting method of the blueberry anthocyanin, includes the following steps：Fresh blueberry is adopted under the conditions of being protected from light for 4-8 DEG C
16h is extracted with the citric acid ethanol solution that volume fraction is 5%；Extracting solution is through centrifugation, ultra-filtration and separation, chromatographic purifying, vacuum refrigeration
The processing such as dry, can be obtained the blueberry anthocyanin of high-purity.
The primary raw material of the superelevation Gel baits albumen powder is egg；The Gel baits of the superelevation Gel baits albumen powder
Intensity is 1600g/cm2。
Comparative example 1
By in embodiment 1 blueberry anthocyanin and the removal of superelevation Gel baits albumen powder, remaining proportion is constant.
Comparative example 2
By the blueberry anthocyanin removal in embodiment 1, remaining proportion is constant.
Comparative example 3
By the superelevation Gel baits albumen powder removal in embodiment 1, remaining proportion is constant.
Comparative example 4
It is 600g/cm that superelevation Gel baits albumen powder in embodiment 1, which is replaced with colloidality intensity,2Routine protein powder, remaining is matched
Than constant.
Clinical comparison test is carried out to the sample of embodiment 1-3 and comparative example 1-4 below, specific test method is as follows：
Patient's choosing method：
Choose refractory asthma patient 350.All patients voluntarily agree to participate in this research, and endorsed and know together
Meaning book.350 patients are divided into embodiment 1-3 and comparative example 1-4 group at random, 7 groups of patients are 50.7 groups of patients are in property
Not, the difference in terms of the basic documents such as age, state of an illness is unobvious, compares without statistical significance（P > 0.05）.Patient is in difficulty
It is comparable in the treatment of the property controlled asthma clinical.All patients meet " the refractory asthma diagnosis of American Thoracic Society's formulation
Standard "（2000）.Exclusion criteria：1. the person that cannot grasp administrated method；2. with other systems disease patients such as the heart, liver, kidneys；③
With severe sinus inflammation person；4. the person that has habits of smoking and alcohol drinking；5. the gestational period or breast feeding women；6. midway is because of drug allergy or other originals
Because of bolter；7. suffering from gastroesophageal reflux person；8. suffering from bronchiectasis, pulmonary tuberculosis isostructuralism lung patient；9. cannot comply with
Research approach person.
Treatment method：
Embodiment 1-3 and comparative example 1-4 group patient take compound salbutamol sulfate capsule daily, one time 3（0.15g/）,
Three times a day, 24 weeks it is as a treatment course.
Curative effect determinate standard：
1. effective：Refractory asthma clinical symptoms disappear, and lung's wheezing sound disappears, and can control asthma attack using conventional therapy.
2. improving：Refractory asthma clinical symptoms are obviously improved, and lung's wheezing sound mitigates.3. invalid：Refractory asthma clinical symptoms without
Improve, or even aggravates.Effective percentage statistics includes effective and improvement patient.Specific therapeutic effect is shown in Table 1.
If having recurrence in 3 years, the compound salbutamol sulfate capsule is reused, it is efficient to calculate recurrence（Same patient
If repeating to break out, repeat to count）.
Table 1：The therapeutic effect of patient；
| It is effective | It improves | In vain | Efficient % | Recur effective percentage % | |
| Embodiment 1 | 42 | 8 | 0 | 100 | 100 |
| Embodiment 2 | 41 | 9 | 0 | 100 | 100 |
| Embodiment 3 | 42 | 8 | 0 | 100 | 100 |
| Comparative example 1 | 29 | 15 | 6 | 88 | 58 |
| Comparative example 2 | 30 | 13 | 7 | 86 | 55 |
| Comparative example 3 | 35 | 11 | 4 | 92 | 74 |
| Comparative example 4 | 37 | 9 | 4 | 92 | 76 |
After tested, the compound salbutamol sulfate capsule of the invention for having good therapeutic effect to asthma, it is significant in efficacy, and be added
After blueberry anthocyanin and superelevation Gel baits albumen powder, patient can be effectively reduced to the drug resistance of the capsule.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of compound salbutamol sulfate capsule suitable for refractory asthma, which is characterized in that its effective component is：Sulfuric acid
Salbutamol and beclomeasone propionate.
2. being suitable for the compound salbutamol sulfate capsule of refractory asthma as described in claim 1, which is characterized in that it has
Imitating ingredient further includes blueberry anthocyanin.
3. being suitable for the compound salbutamol sulfate capsule of refractory asthma as described in claim 1, which is characterized in that including
The ingredient of following parts by weight：200-500 parts of low-substituted hydroxypropyl cellulose, 60-80 parts of crospovidone, blueberry anthocyanin 8-
15 parts, 40-60 parts of superelevation Gel baits albumen powder, 10-20 parts of lauryl sodium sulfate, 15-20 parts of magnesium stearate, sulfuric acid sand fourth
3-6 parts and 1 part of beclomeasone propionate of amine alcohol.
4. being suitable for the compound salbutamol sulfate capsule of refractory asthma as claimed in claim 3, which is characterized in that described
Blueberry anthocyanin extracting method, include the following steps：By fresh blueberry used under the conditions of being protected from light for 4-8 DEG C volume fraction for
The citric acid ethanol solution of 2-5% extracts 16-20h；Extracting solution is through centrifugation, ultra-filtration and separation, chromatographic purifying, vacuum freeze drying etc.
Processing, can be obtained the blueberry anthocyanin of high-purity.
5. being suitable for the compound salbutamol sulfate capsule of refractory asthma as claimed in claim 3, which is characterized in that described
Superelevation Gel baits albumen powder primary raw material be egg.
6. being suitable for the compound salbutamol sulfate capsule of refractory asthma as claimed in claim 5, which is characterized in that described
Superelevation Gel baits albumen powder Gel baits intensity be 1200-1600g/cm2。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811111879.1A CN108836958A (en) | 2018-09-25 | 2018-09-25 | A kind of compound salbutamol sulfate capsule suitable for refractory asthma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811111879.1A CN108836958A (en) | 2018-09-25 | 2018-09-25 | A kind of compound salbutamol sulfate capsule suitable for refractory asthma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108836958A true CN108836958A (en) | 2018-11-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811111879.1A Pending CN108836958A (en) | 2018-09-25 | 2018-09-25 | A kind of compound salbutamol sulfate capsule suitable for refractory asthma |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101914304A (en) * | 2010-07-30 | 2010-12-15 | 合肥工业大学 | Method for extracting blueberry anthocyanin |
| CN107156584A (en) * | 2017-05-12 | 2017-09-15 | 沈阳农业大学 | A kind of preparation method of not old certain kind of berries dried fruit juice |
-
2018
- 2018-09-25 CN CN201811111879.1A patent/CN108836958A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101914304A (en) * | 2010-07-30 | 2010-12-15 | 合肥工业大学 | Method for extracting blueberry anthocyanin |
| CN107156584A (en) * | 2017-05-12 | 2017-09-15 | 沈阳农业大学 | A kind of preparation method of not old certain kind of berries dried fruit juice |
Non-Patent Citations (2)
| Title |
|---|
| SANG-JOON PARK等: "Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model", 《FOOD AND CHEMICAL TOXICOLOGY》 * |
| 石岩: "沙丁胺醇联合丙酸倍氯米松治疗成人哮喘的疗效观察", 《临床合理用药》 * |
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Application publication date: 20181120 |
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