CN108835026A - A kind of new Chronic Stress Model - Google Patents
A kind of new Chronic Stress Model Download PDFInfo
- Publication number
- CN108835026A CN108835026A CN201810467853.4A CN201810467853A CN108835026A CN 108835026 A CN108835026 A CN 108835026A CN 201810467853 A CN201810467853 A CN 201810467853A CN 108835026 A CN108835026 A CN 108835026A
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- China
- Prior art keywords
- slot
- storage rack
- tube
- tube body
- chronic stress
- Prior art date
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Links
- 230000037326 chronic stress Effects 0.000 title claims abstract description 23
- 210000003608 fece Anatomy 0.000 claims abstract description 18
- 230000007246 mechanism Effects 0.000 claims abstract description 12
- 230000013872 defecation Effects 0.000 claims abstract description 4
- 230000009471 action Effects 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000035882 stress Effects 0.000 abstract description 22
- 230000008901 benefit Effects 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 abstract description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 18
- 206010028980 Neoplasm Diseases 0.000 description 12
- 201000011510 cancer Diseases 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 230000008645 cold stress Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 230000006353 environmental stress Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention patent relates to a kind of new Chronic Stress Models,Including centrifuge tube,Storage rack,Support frame and excreta tray,The centrifuge tube is made of tube body and dome,The tube wall of the tube body is transparent,The top of tube body is in pyramid type,Its bottom is in open state,The dome is detachably connected to the bottom of tube body,Venthole is all offered on the top of the tube body and the tube wall of upper end surrounding,The through-hole for defecation of urinating is offered at the center of the dome,The through slot for storing centrifuge tube is offered on the storage rack,The centrifuge tube is movably connected in through slot,The support frame is made of left support and right support,The storage rack is connected between left support and right support by height adjustment mechanism,The excreta tray is detachably connected between left support and right support.The present invention has the advantages that easy to operate, low in cost, is suitble to almost all of mouse stress tests.
Description
Technical field
The invention patent relates to treatment of cancer studying technological domain, especially a kind of new Chronic Stress Model.
Background technique
" talk about cancer discoloration " vividly described cancer patient learn will face after " cancer " diagnosis treatment relevant with tumour,
It lapses to, tumor recurrence and because extremely forgetting caused by tumour, these will become the major chronic stress factor of cancer patient.Patient faces
The pressure of " cancer may recur ", be chronically at " chronic stress state ", research point out that chronic stress may promote tumour
Growth, progress and transfer；So in order to preferably explore stress to the influence of body, design it is a kind of caused to experimental animal it is chronic
Stress Stress model be just particularly important.
Summary of the invention
The object of the invention is to design a kind of new Chronic Stress Model, various ways (constraint can be but provided to mouse
Stress, society's separation stress, Cold stress, excrement stress) stress, be in mouse and suffer from identical chronic stress after cancer with people
In state, the accuracy of experiment detection is improved.
In order to solve the above technical problems, the present invention provides a kind of new Chronic Stress Models, including
Centrifuge tube, the centrifuge tube are made of tube body and dome, and the tube wall of the tube body is transparent, tube body
Top be in pyramid type, bottom is in open state, and the dome is detachably connected to the bottom of tube body, the tube body
Venthole is all offered on the tube wall of top and upper end surrounding, is offered at the center of the dome for defecation of urinating
Through-hole,
Storage rack offers the through slot for storing centrifuge tube on the storage rack, and the activity of the centrifuge tube is even
It connects in through slot,
Support frame, the support frame are made of left support and right support, and the storage rack passes through height adjustment
Mechanism is connected between left support and right support,
Excreta tray, the excreta tray is detachably connected between left support and right support, described
Excreta tray be located at the underface of storage rack.
Further：The through slot is made of the first through slot being connected to up and down and the second through slot, and described first is logical
Slot and the second through slot are all round groove body, and the outer diameter of the tube body of the internal diameter and centrifuge tube of first through slot matches, described
The second through slot internal diameter be less than dome diameter and be greater than through-hole diameter.
Further：The diameter of the centrifuge tube is 30mm, and the length is 115mm, the internal diameter of the through-hole is
10mm, the internal diameter of the venthole are 5mm.
Further：4 row's through slots are successively offered on the storage rack, the quantity of every row's through slot is 10.
Further：The height adjustment mechanism includes that left support and screw rod on right support inner wall is arranged in, sets
The connection in storage rack two sides and adjusting nut are set, the attachment base of the storage rack two sides is movably connected in the screw rod of two sides
On, an adjusting nut is respectively connected on the adjusting nut of two sides above and below the attachment base.
Further：Guide holder is both provided on the inner wall of the left support and right support, the excreta is deposited
The two sides of sale at reduced prices are provided with sliding block, and the guide groove to match with sliding block, the sliding block activity are offered on the guide holder
It is connected in guide groove.
Further：Elastic clamping mechanism, the elastic clamping machine are additionally provided between the sliding block and guide groove
Structure includes the groove being provided on guide groove inner wall, the hemispherical card slot being provided on sliding block outer wall, spherical clamp and spring, institute
The spherical clamp stated is connected in groove by spring, and the spherical clamp is caught in hemispherical card slot under the action of the spring
It is interior.
The present invention but can provide a variety of sides to mouse by designing a kind of new Chronic Stress Model after adopting the above structure
Formula (Restraint Stress, society's separation stress, Cold stress, excrement stress) stress, make mouse be in suffer from people it is identical after cancer
In chronic stress state, the accuracy of experiment detection is improved；And the present invention also has easy to operate, low-cost excellent
Point is suitble to almost all of mouse stress tests.
Detailed description of the invention
The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.
Fig. 1 is the structural schematic diagram of centrifuge tube.
Fig. 2 is the structural schematic diagram of support frame.
Fig. 3 is the enlarged drawing of A in Fig. 2.
Specific embodiment
A kind of new Chronic Stress Model as depicted in figs. 1 and 2, including centrifuge tube, storage rack 7, support frame 6 and excretion
Object tray 8, the centrifuge tube are made of tube body 1 and dome 2, and the tube wall of the tube body 1 is transparent, tube body 1
Top be in pyramid type, bottom is in open state, and the dome 2 is detachably connected to the bottom of tube body 1, the tube body
Venthole 3 is all offered on 1 top and the tube wall of upper end surrounding, is offered at the center of the dome 2 for urinating
The through-hole 5 of defecation offers the through slot 9 for storing centrifuge tube, the flexible connection of the centrifuge tube on the storage rack 7
In through slot 9, the support frame 6 is made of left support and right support, and the storage rack 7 passes through height adjustment mechanism
It being connected between left support and right support, the excreta tray 8 is detachably connected between left support and right support,
The excreta tray 8 is located at the underface of storage rack 7；The through slot 9 is the first through slot and by being connected to up and down
Two through slots are formed, and first through slot and the second through slot are all round groove body, the internal diameter of first through slot and centrifugation
The outer diameter of the tube body 1 of pipe matches, and the internal diameter of second through slot is less than the diameter of dome 2 and is greater than the diameter of through-hole 5；Institute
The diameter for the centrifuge tube stated is 30mm, and the length is 115mm, the internal diameter of the through-hole 5 is 10mm, the venthole 3
Internal diameter is 5mm；4 row's through slots 9 are successively offered on the storage rack 7, the quantity of every row's through slot 9 is 10.When experiment, every
Mouse is individually placed in centrifuge tube, and centrifuge tube is placed in storage rack 7, and daily support frame 6 is placed on 4 degrees Celsius of low temperature ring
In border 2 hours daily, continue 7-14 days.The present invention can but be provided more by designing a kind of new Chronic Stress Model to mouse
Kind of mode (Restraint Stress, society's separation stress, Cold stress, excrement stress) stress, be in mouse and suffer from phase after cancer with people
In same chronic stress state, the accuracy of experiment detection is improved；And the present invention also has easy to operate, low-cost
Advantage is suitble to almost all of mouse stress tests.
1. every mouse, which is tied in the centrifuge tube of limitation, forms Restraint Stress.2. mouse is placed in individually band ventilation
It in the centrifuge tube of hole, is held together, can hear mutual sound and smells mutual smell, have the separation of part society and answer
Swash the effect of model.3. by be placed on provide one kind to experimental mouse in 4 degrees Celsius of low temperature environment stress.4. by dome
On open up through-hole, the urine excrement of mouse can be fallen into excreta tray 8 by through-hole, on the one hand play convenient for cleaning work
With, on the other hand this two hours stress during excreta itself in centrifuge tube be also stress to one kind of mouse；This mould
The urine excrement that all mouse stress drain in the process is collected the urine excrement pair of total mice in the excreta tray 8 of bottom by type
Whole mouse formed common equalization stress, can farthest guarantee the consistency of each mouse experiment condition.
Height adjustment mechanism as shown in Figure 2 includes the screw rod 10 being arranged on left support and right support inner wall, setting
The attachment base 12 of attachment base 12 and adjusting nut 11 in 7 two sides of storage rack, 7 two sides of storage rack is movably connected in two
On the screw rod 10 of side, it is respectively connected with an adjusting nut 11 on the adjusting nut 11 of about 12 two sides of attachment base, is originally set
Meter can be adjusted the height of storage rack 7, to change the distance that mouse urinates excrement in excreta tray 8, have
Have the advantages that structure is simple, easily fabricated and practical and efficient.
Guide holder 13, the excreta storage are both provided on the inner wall of left support and right support as shown in Figure 2
The two sides of disk 8 are provided with sliding block 14, and the guide groove to match with sliding block 14, the sliding block are offered on the guide holder 13
14 are movably connected in guide groove, excreta tray 8 can individually be taken out, be played convenient for clear by using above structure
The effect washed.
Elastic clamping mechanism, the elastic clamping mechanism are additionally provided between sliding block 14 as shown in Figure 3 and guide groove
Including the groove 16 being provided on guide groove inner wall, the hemispherical card slot 15 being provided on 14 outer wall of sliding block, 17 and of spherical clamp
Spring 18, the spherical clamp 17 are connected in groove 16 by spring 18, work of the spherical clamp 17 in spring 18
It is caught under in hemispherical card slot 15, plays the role of being easily installed and dismantle by using above structure.
Claims (7)
1. a kind of new Chronic Stress Model, it is characterised in that：Including
Centrifuge tube, the centrifuge tube are made of tube body (1) and dome (2), and the tube wall of the tube body (1) is transparent
Shape, the top of tube body (1) are in pyramid type, and bottom is in open state, and the dome (2) is detachably connected to tube body (1)
It is all offered venthole (3) on bottom, the top of the tube body (1) and the tube wall of upper end surrounding, the dome (2)
The through-hole (5) for defecation of urinating is offered at center,
Storage rack (7) offers the through slot (9) for storing centrifuge tube, the work of the centrifuge tube on the storage rack (7)
It is dynamic to be connected in through slot (9),
Support frame (6), the support frame (6) are made of left support and right support, and the storage rack (7) passes through height
Regulating mechanism is connected between left support and right support,
Excreta tray (8), the excreta tray (8) are detachably connected between left support and right support, institute
The excreta tray (8) stated is located at the underface of storage rack (7).
2. the new Chronic Stress Model of one kind according to claim 1, it is characterised in that：The through slot (9) is by upper
The first through slot and the second through slot of lower connection are formed, and first through slot and the second through slot are all round groove body, described
The outer diameter of the tube body (1) of the internal diameter and centrifuge tube of first through slot matches, and the internal diameter of second through slot is less than dome (2)
Diameter and the diameter for being greater than through-hole (5).
3. the new Chronic Stress Model of one kind according to claim 1, it is characterised in that：The diameter of the centrifuge tube is
30mm, the length is 115mm, the internal diameter of the through-hole (5) is 10mm, and the internal diameter of the venthole (3) is 5mm.
4. the new Chronic Stress Model of one kind according to claim 1, it is characterised in that：On the storage rack (7) according to
Secondary to offer 4 row's through slots (9), the quantity of every row's through slot (9) is 10.
5. the new Chronic Stress Model of one kind according to claim 1, it is characterised in that：The height adjustment mechanism packet
It includes the screw rod (10) being arranged on left support and right support inner wall, the attachment base (12) and tune in storage rack (7) two sides is set
It saves nut (11), the attachment base (12) of the storage rack (7) two sides is movably connected on the screw rod (10) of two sides, the company
Joint chair (12) is respectively connected with an adjusting nut (11) on the adjusting nut (11) of two sides up and down.
6. the new Chronic Stress Model of one kind according to claim 1, it is characterised in that：The left support and right branch
It is both provided on the inner wall of frame guide holder (13), the two sides of the excreta tray (8) are provided with sliding block (14), described
The guide groove to match with sliding block (14) is offered on guide holder (13), the sliding block (14) is movably connected in guide groove.
7. the new Chronic Stress Model of one kind according to claim 6, it is characterised in that：The sliding block (14) and guiding
Elastic clamping mechanism is additionally provided between slot, the elastic clamping mechanism includes the groove being provided on guide groove inner wall
(16), hemispherical card slot (15), spherical clamp (17) and the spring (18) being provided on sliding block (14) outer wall, the spherical clip
Head (17) is connected in groove (16) by spring (18), and the spherical clamp (17) is caught in half under the action of spring (18)
In spherical card slot (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810467853.4A CN108835026A (en) | 2018-05-16 | 2018-05-16 | A kind of new Chronic Stress Model |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810467853.4A CN108835026A (en) | 2018-05-16 | 2018-05-16 | A kind of new Chronic Stress Model |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108835026A true CN108835026A (en) | 2018-11-20 |
Family
ID=64213153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810467853.4A Pending CN108835026A (en) | 2018-05-16 | 2018-05-16 | A kind of new Chronic Stress Model |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108835026A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203341846U (en) * | 2013-07-12 | 2013-12-18 | 中国人民解放军军事医学科学院基础医学研究所 | Rat constraining device |
| CN104622584A (en) * | 2015-03-13 | 2015-05-20 | 河南中医学院 | Animal chronic fear stress meter based on danger method |
| CN204364165U (en) * | 2014-12-15 | 2015-06-03 | 同济大学 | A kind of tail vein injection experiment mice holder |
| KR20160042307A (en) * | 2014-10-08 | 2016-04-19 | 울산대학교 산학협력단 | Assistant equipment for Intravenous injection and blood collecting of Rat |
| CN205388543U (en) * | 2015-09-30 | 2016-07-20 | 陕西师范大学 | Device of metabolite during constraint of collection rat |
| CN205903325U (en) * | 2016-04-28 | 2017-01-25 | 成都中医药大学 | Device is restricted to mouse |
| CN106706874A (en) * | 2016-12-31 | 2017-05-24 | 郑州贯奥仪器仪表有限公司 | Test tube storage device used for water quality detector |
| CN209089723U (en) * | 2018-05-16 | 2019-07-12 | 邓国华 | A kind of new Chronic Stress Model |
-
2018
- 2018-05-16 CN CN201810467853.4A patent/CN108835026A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203341846U (en) * | 2013-07-12 | 2013-12-18 | 中国人民解放军军事医学科学院基础医学研究所 | Rat constraining device |
| KR20160042307A (en) * | 2014-10-08 | 2016-04-19 | 울산대학교 산학협력단 | Assistant equipment for Intravenous injection and blood collecting of Rat |
| CN204364165U (en) * | 2014-12-15 | 2015-06-03 | 同济大学 | A kind of tail vein injection experiment mice holder |
| CN104622584A (en) * | 2015-03-13 | 2015-05-20 | 河南中医学院 | Animal chronic fear stress meter based on danger method |
| CN205388543U (en) * | 2015-09-30 | 2016-07-20 | 陕西师范大学 | Device of metabolite during constraint of collection rat |
| CN205903325U (en) * | 2016-04-28 | 2017-01-25 | 成都中医药大学 | Device is restricted to mouse |
| CN106706874A (en) * | 2016-12-31 | 2017-05-24 | 郑州贯奥仪器仪表有限公司 | Test tube storage device used for water quality detector |
| CN209089723U (en) * | 2018-05-16 | 2019-07-12 | 邓国华 | A kind of new Chronic Stress Model |
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